CN104489684A - Healthcare food capable of enhancing immunity and preparation method of healthcare food - Google Patents
Healthcare food capable of enhancing immunity and preparation method of healthcare food Download PDFInfo
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Abstract
The invention relates to healthcare food capable of enhancing the immunity and a preparation method of the healthcare food. The healthcare food consists of the following raw materials by weight percent: 50 to 60 percent of American ginseng wall-broken powder, 15 to 25 percent of salvia wall-broken powder, 15 to 25 percent of ginseng wall-broken powder and 0 to 2 percent of silicon dioxide. By mixing the American ginseng wall-broken powder, the salvia wall-broken powder and the ginseng wall-broken powder in an appropriate ratio, the healthcare food is safe to orally take, the dissolution rate is improved, the absorption rate of the human body for the nutrients can be improved, the effect can be rapid to realize, the biological availability is high, the process is easy to operate, no special device or chemical reagent is used, the production is safe, the technological condition is stable, no problem for treating waste gas, waste water and waste residues exists, and the healthcare food is applicable to the industrialized mass production.
Description
Technical field
The present invention relates to health food of a kind of develop immunitypty and preparation method thereof, belong to health food and manufacture field.
Background technology
Immunity is the defense mechanism of human body self, is the physiological reaction of human bioequivalence and eliminating " dissident ".In recent years due to environmental pollution, drug abuse, nervous, live irregular, the factors such as exercise that lack exercise cause the problem of people's hypoimmunity more and more outstanding, and breaking out of various epidemic disease allows people recognize the importance improving autoimmunity especially.
Found by investigation, in 14000 plurality kinds of health care food of national approved, have more than 2400 product to have develop immunitypty function, ratio is quite large.The health product of current domestic develop immunitypty mainly comprises: ginseng class health food, vitamins health food, the product of microelement kind health food and some other raising immunity function declared, these products develop immunitypty all from different perspectives, but there is unicity in formula, effect value characteristic does not have outstanding advantage relatively.
Summary of the invention
Technical problem to be solved by this invention is to provide health food of a kind of develop immunitypty and preparation method thereof, using American Ginseng wall cell disruption powder body, red sage root broken wall powder, ginseng broken wall powder as composition, the product obtained takes safety, dissolution rate, bioavilability are high, absorptivity is fast, onset is rapid, and process stabilizing is easy to operate applicable large-scale production.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of health food of develop immunitypty, be made up of following raw material: American Ginseng broken wall powder 50% ~ 60%, red sage root broken wall powder 15% ~ 25%, ginseng broken wall powder 15% ~ 25%, silica 0% ~ 2%.
The invention has the beneficial effects as follows: the present invention owing to have employed American Ginseng broken wall powder, red sage root broken wall powder, ginseng broken wall powder coordinate oral safety in the proper ratio, improve dissolution rate, improve human body to the absorptivity of its nutritional labeling, onset is rapid, bioavilability is high and technique is easy to operation, without special installation and chemical reagent, and production safety, stable process conditions, process problem without " three wastes ", be suitable for industrialized production.
On the basis of technique scheme, the present invention can also do following improvement.
The present invention also provides a kind of preparation method of health food of develop immunitypty, comprise the following steps: the preparation of step (1) American Ginseng, the red sage root and ginseng broken wall powder, first American Ginseng, the red sage root and ginseng are carried out respectively primary comminution and cross 60 ~ 100 mesh sieves, again ultramicro grinding to particle diameter 5 ~ 50 μm of scopes, sterilizing, weighing and bagging is for subsequent use;
Step (2) allotment mixing granulation; American Ginseng broken wall powder powder, red sage root broken wall powder powder and ginseng broken wall powder powder prepared by step (1) is taken according to claim 1 part by weight; be uniformly mixed to obtain mixed powder; in high speed wet granulator; add concentration more than 30wt% ethanol; cross 12-20 mesh sieve and make wet granular, wet granular, in being dried to moisture lower than 5wt%, arranges to obtain dry particle.
The preparation method of the health food of the present invention's a kind of develop immunitypty as above, further, also comprise the treatment step before American Ginseng and ginseng primary comminution: be respectively charged on the guipure of DWT mesh-belt drier after American Ginseng and ginseng are removed impurity and dis-medicinal part, be dried to moisture in 60-70 DEG C and be no more than 9.0%.
The preparation method of the health food of the present invention's a kind of develop immunitypty as above, further, also comprise demulcen step: put into medicine-washing machine after the red sage root being removed impurity and dis-medicinal part and wash away silt, then load in clean plastic crate, demulcen 15 ~ 20h, makes red rooted salvia soften, and the red sage root softened is cut into short section of 5 ~ 10mm, load on the guipure of DWT mesh-belt drier, be dried to moisture in 60 ~ 70 DEG C and be no more than 9.0%.
The preparation method of the health food of the present invention's a kind of develop immunitypty as above, further, the sterilising conditions described in step (1) is: ultraviolet sterilization 30min, ozone sterilization 180min.
The present invention adopts this sterilization process and parameter, can farthest sterilizing and retain the nutritive value of American Ginseng, the red sage root and ginseng.
The preparation method of the health food of the present invention's a kind of develop immunitypty as above, further, step (2) arranges to obtain dry particle, adds silica and mixes, and obtains total mixture material; By above-mentioned total mixture in dust proof workshop, with automatic tire bagger dress capsule, polishing, bottled, sealing, packaging, product inspection, warehouse-in.
The health food gone out prepared by preparation method of the present invention is due to direct employing, after American Ginseng, the red sage root and ginseng broken wall powder primary comminution, the powder of ultramicro grinding to particle size range 5-50 μm is primary raw material, can reinvigoration simultaneously tonifying QI to produce body fluid, make qi-blood-body fluidization raw active, tonifying Qi does not stay heresy, reaches the health-care efficacy of develop immunitypty.And persistent, raw material sources are extensive, the material benefit of reliable in quality, price.
American Ginseng, the functional component of ginseng comprises its saponin component and polysaccharide composition etc., the active ingredient of the red sage root not only comprises liposoluble constituent but also comprise water soluble ingredient, the present invention is with American Ginseng wall cell disruption powder body, ginseng broken wall powder, red sage root broken wall powder is directly used as medicine, remain American Ginseng to greatest extent, to the useful multiple bioactive ingredients of human body and rare trace elements in the red sage root and ginseng, and improve dissolution rate, improve human body to the absorptivity of its nutritional labeling, onset is rapid, bioavilability is high, reach boosting qi and nourishing yin, clearing heat and promoting fluid, the effect of body function.
Prepared by the inventive method can be prepared into capsule by this health food, good looking appearance, takes easy to carry; Technique is simple, with low cost, and being applicable to vastly needs crowd.
Detailed description of the invention
Be described principle of the present invention and feature with the following Examples, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1
The health food of a kind of develop immunitypty of the present invention, is made up of following raw material: American Ginseng broken wall powder 50kg, red sage root broken wall powder 25kg, ginseng broken wall powder 24kg, silica 1 kg.
The method of the health food of the present invention's develop immunitypty as above comprises the steps:
(1) preparation of American Ginseng broken wall powder powder
Get the American Ginseng be up to the standards and roughly select removal impurity and dis-medicinal part, American Ginseng after roughly selecting is loaded on DWT mesh-belt drier guipure, be 6.0wt% in 60 DEG C of dried machines to moisture, through thin choosing, primary comminution crosses 80 mesh sieves, then ultramicro grinding to particle size range at 10-15 μm, ultraviolet sterilization 30min, ozone sterilization 180min, weighing and bagging is for subsequent use.
(2) preparation of red sage root broken wall powder powder
Get the red sage root be up to the standards and roughly select removal impurity and dis-medicinal part, the red sage root after roughly selecting is put into medicine-washing machine and washes away silt, then load in clean plastic crate, demulcen 20h, medicinal material is softened, to short section that the red sage root moistened cuts into 6mm be washed, the red sage root after cutting is loaded on DWT mesh-belt drier guipure, be 7.0% in 70 DEG C of dried machines to moisture, through carefully selecting, primary comminution crosses 80 mesh sieves, again ultramicro grinding to particle size range at 10-15 μm, ultraviolet sterilization 30min, ozone sterilization 180min, weighing and bagging is for subsequent use.
(3) preparation of ginseng broken wall powder powder
Get the ginseng be up to the standards and roughly select removal impurity and dis-medicinal part, ginseng after roughly selecting is loaded on DWT mesh-belt drier guipure, be 8.0wt% in 70 DEG C of dried machines to water, through thin choosing, primary comminution crosses 80 mesh sieve powder, then ultramicro grinding to D90 at 5-20 μm, ultraviolet sterilization 30min, ozone sterilization 180min, weighing and bagging is for subsequent use.
(4) mixing granulation is allocated
At the American Ginseng broken wall powder powder that 300,000 grades of dust proof workshops are prepared by recipe ratio weighing step (1); the red sage root broken wall powder powder prepared with step (2); ginseng broken wall powder powder prepared by step (3); be uniformly mixed to obtain mixed powder; in high speed wet granulator; add concentration and be greater than 30% hydrous ethanol softwood; cross 12 mesh sieves to granulate; it is 3wt% that wet granular is dried to moisture in 50 DEG C; arrange to obtain dry particle; add silica to mix, obtain total mixture material, for subsequent use.
(5) filled capsules, packaging
At 300,000 grades of dust proof workshops, by above-mentioned total mixture material with automatic tire bagger dress capsule, polishing, bottled, sealing, packaging;
(6) product inspection, warehouse-in
As requested every detection is carried out to finished product, the warehouse-in conformed with the regulations.
Embodiment 2
The health food of a kind of develop immunitypty of the present invention, is made up of following raw material: American Ginseng broken wall powder 55kg, red sage root broken wall powder 24kg, ginseng broken wall powder 20kg, silica 1 kg.
The method preparing the health food of develop immunitypty as above comprises the steps:
(1) preparation of American Ginseng broken wall powder powder
Get the American Ginseng be up to the standards and roughly select removal impurity and dis-medicinal part, American Ginseng after roughly selecting is loaded on DWT mesh-belt drier guipure, be 5.0wt% in 65 DEG C of dried machines to moisture, through thin choosing, primary comminution crosses 80 mesh sieves, then ultramicro grinding to particle size range at 8 ~ 15 μm, ultraviolet sterilization 30min, ozone sterilization 180min, weighing and bagging is for subsequent use.
(2) preparation of red sage root broken wall powder powder
Get the red sage root be up to the standards and roughly select removal impurity and dis-medicinal part, the red sage root after roughly selecting is put into medicine-washing machine and washes away silt, then load in clean plastic crate, demulcen 20h, medicinal material is softened, to short section that the red sage root moistened cuts into 8mm be washed, the red sage root after cutting is loaded on DWT mesh-belt drier guipure, be 5.0wt% in 70 DEG C of dried machines to moisture, through carefully selecting, primary comminution crosses 80 mesh sieves, again ultramicro grinding to particle diameter at 30 ~ 50 μm, ultraviolet sterilization 30min, ozone sterilization 180min, weighing and bagging is for subsequent use.
(3) preparation of ginseng broken wall powder powder
Get the ginseng be up to the standards and roughly select removal impurity and dis-medicinal part, ginseng after roughly selecting is loaded on DWT mesh-belt drier guipure, be 6.0wt% in 60 ~ 70 DEG C of dried machines to moisture, through thin choosing, primary comminution crosses 80 mesh sieve powder, then ultramicro grinding to particle diameter at 30 ~ 50 μm, outer sterilizing 30min, ozone sterilization 180min, weighing and bagging is for subsequent use.
(4) mixing granulation is allocated
At the American Ginseng broken wall powder powder that 300,000 grades of dust proof workshops are prepared by recipe ratio weighing step (1); the red sage root broken wall powder powder prepared with step (2); ginseng broken wall powder powder prepared by step (3); be uniformly mixed to obtain mixed powder; in high speed wet granulator; add concentration and be greater than 30% hydrous ethanol softwood; cross 20 mesh sieves to granulate; it is 4% that wet granular is dried to moisture in 60 DEG C; arrange to obtain dry particle; add silica to mix, obtain total mixture material, for subsequent use.
(5) filled capsules, packaging
At 300,000 grades of dust proof workshops, by above-mentioned total mixture material with automatic tire bagger dress capsule, polishing, bottled, sealing, packaging;
(6) product inspection, warehouse-in
As requested every detection is carried out to finished product, the warehouse-in conformed with the regulations.
Embodiment 3
The health food of a kind of develop immunitypty of the present invention, is made up of following raw material: American Ginseng broken wall powder 60kg, red sage root broken wall powder 18kg, ginseng broken wall powder 22kg, silica 0kg.
The method preparing the health food of develop immunitypty as above comprises the steps:
(1) preparation of American Ginseng broken wall powder powder
Get the American Ginseng be up to the standards and roughly select removal impurity and dis-medicinal part, American Ginseng after roughly selecting is loaded on DWT mesh-belt drier guipure, be 9.0wt% in 70 DEG C of dried machines to moisture, through thin choosing, primary comminution crosses 80 mesh sieves, then ultramicro grinding to particle diameter at 20 ~ 30 μm, ultraviolet sterilization 30min, ozone sterilization 180min, weighing and bagging is for subsequent use.
(2) preparation of red sage root broken wall powder powder
Get the red sage root be up to the standards and roughly select removal impurity and dis-medicinal part, the red sage root after roughly selecting is put into medicine-washing machine and washes away silt, then load in clean plastic crate, demulcen 18h, medicinal material is softened, to short section that the red sage root moistened cuts into 7mm be washed, the red sage root after cutting is loaded on DWT mesh-belt drier guipure, be 9.0wt% in 70 DEG C of dried machines to moisture, through carefully selecting, primary comminution crosses 80 mesh sieves, again ultramicro grinding to particle diameter at 20 ~ 30 μm, ultraviolet sterilization 30min, ozone sterilization 180min, weighing and bagging is for subsequent use.
(3) preparation of ginseng broken wall powder powder
Get the ginseng be up to the standards and roughly select removal impurity and dis-medicinal part, the ginseng after roughly selecting is loaded DWT.On mesh-belt drier guipure, be 9.0wt% in 70 DEG C of dried machine moistures, through carefully selecting, primary comminution crosses 80 mesh sieve powder, then ultramicro grinding to particle diameter at 20 ~ 30 μm, ultraviolet sterilization 30min, ozone sterilization 180min, weighing and bagging is for subsequent use.
(4) mixing granulation is allocated
At the American Ginseng broken wall powder powder that 300,000 grades of dust proof workshops are prepared by recipe ratio weighing step (1); the red sage root broken wall powder powder prepared with step (2); ginseng broken wall powder powder prepared by step (3); be uniformly mixed to obtain mixed powder; in high speed wet granulator; add concentration and be greater than 30% hydrous ethanol softwood; cross 18 mesh sieves to granulate; it is 5wt% that wet granular is dried to moisture in 55 DEG C; arrange to obtain dry particle; add silica to mix, obtain total mixture material, for subsequent use.
(5) filled capsules, packaging
At 300,000 grades of dust proof workshops, by above-mentioned total mixture material with automatic tire bagger dress capsule, polishing, bottled, sealing, packaging;
(6) product inspection, warehouse-in
As requested every detection is carried out to finished product, the warehouse-in conformed with the regulations.
According to the progresses and methods that security and the functional trial of " health food inspection and assessment technical specification " (version in 2003) are evaluated, significant composition, hygiene, stability, toxicology, function assessment (develop immunitypty function) inspection are carried out to the health food that the embodiment of the present invention 1 to embodiment 3 prepares.Experimental technique is as follows, and experimental result refers to table 1 to table 8.
1, toxicological experiment
1.1 acute oral toxicity tests:
Animal used as test: female, the male mouse of Kunming kind (SPF level)
Experimental technique and step: adopt maximum tolerated dose method, weighed by Kunming mouse, and random packet, gastric infusion, observes and records animal state.
1.2 3 genetic toxicity tests
1.2.1 mice bone marrow micronucleus:
Animal used as test: adopt Kunming mouse;
Experimental technique and step: random point 5 groups, male and female half and half.Take endoxan as positive control, distilled water is negative control, if senior middle school's low dose group.
1.2.2 mouse inbred strain:
Animal used as test: male mice in kunming;
Experimental technique and step: be divided into 5 groups at random, take endoxan as positive control, distilled water is negative control, if senior middle school's low dose group.
1.2.3 Salmonella reversion test:
Experimental strain: salmonella typhimurium histidine deficient TA97 TA98 TA100 TA102;
Experimental technique and step: adopt the rat liver microsomes enzyme (S-9) of Polychlorinated biphenyls PCB induction as In vitro metabolism active system.Be divided into 5 dosage, if certainly beam back change, solvent control and Positive mutants agent contrast.
1.3 30 days feeding trials
Animal used as test: SD rat, male and female half and half.
Experimental technique and step: control group, senior middle school's low dose group, health food the present invention prepared gives 25 times of human body RD, 50 times, 100 times of gavages 30 days.
The overall toxicological experiment result display of overall toxicology, the maximal tolerance dose of this health food to experimental animal is greater than 20g/kg*bw, belongs to nontoxic level.Salmonella reversion test, mice bone marrow micronucleus, mouse inbred strain result are feminine gender.Feeding trial result display in 30 days has no obvious toxic-side effects to rat.
Table 1. sample the acute toxicity tests
Table 2. sample female mice Micronucleus test result
* compares p<0.01 with negative control group
Table 3. sample Male mouse bone marrow cell micronucleus test result
* compares p<0.01 with negative control group
Table 4. sample mouse inbred strain result
* compares p<0.01 with negative control group
Table 5. sample becomes result (the 2nd time) (x ± s) to returning of salmonella typhimurium
Table 6. sample 30 days final blood biochemical analysis index (n=10, x ± s) of feeding trial
2, function assessment test
Develop immunitypty function
Health food 4 weeks prepared by the embodiment 1 that per os gavage gives the high, normal, basic dosage of mouse, compare with control group (distilled water) and the independent 3 kinds of materials of American Ginseng (red sage root, ginseng), high dose group can significantly improve mouse delayed allergy ability, lymphocyte transformation ability, antibody-producting cell number (P < 0.05), and each dosage does not all make significant difference (P>0.05) to Mouse Weight growth, thymus gland/body weight ratio, spleen/body weight ratio, the ability of macrophage phagocytic chicken red blood cell, NK cytoactive.
Table 7. sample is on the tardy allergic impact (x ± s) of mouse
Table 8. sample is on the impact (x ± s) of mouse spleen lymphocyte conversion reaction
Table 9. sample is on the impact (x ± s) of mice serum haemolysis speed HD50 value
Table 10. sample is on the impact (x ± s) of mouse boosting cell antibody tormation level
Result as can be seen from table 7 to table 10, health food of the present invention has remarkable develop immunitypty function, and result shows American Ginseng that the present invention adopts and the red sage root and ginseng have significant synergy, 3 kinds of composite effects that can significantly improve independent a kind of material develop immunitypty of material with proper proportion combination.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. a health food for develop immunitypty, is characterized in that, is made up of the raw material of following percentage by weight: American Ginseng broken wall powder 50% ~ 60%, red sage root broken wall powder 15% ~ 25%, ginseng broken wall powder 15% ~ 25%, silica 0% ~ 2%.
2. the preparation method of the health food of a develop immunitypty, it is characterized in that, comprise the following steps: the preparation of step (1) American Ginseng, the red sage root and ginseng broken wall powder, first American Ginseng, the red sage root and ginseng are carried out respectively primary comminution and cross 60 ~ 100 mesh sieves, again ultramicro grinding to particle diameter 5 ~ 50 μm of scopes, sterilizing, weighing and bagging is for subsequent use;
Step (2) allotment mixing granulation; American Ginseng broken wall powder powder, red sage root broken wall powder powder and ginseng broken wall powder powder prepared by step (1) is taken according to claim 1 part by weight; be uniformly mixed to obtain mixed powder; in high speed wet granulator; add concentration more than 30% ethanol; cross 12 ~ 20 mesh sieves and make wet granular, wet granular, in being dried to moisture lower than 5%, arranges to obtain dry particle.
3. the preparation method of the health food of a kind of develop immunitypty according to claim 2, it is characterized in that, also comprise the treatment step before American Ginseng and ginseng primary comminution: be respectively charged on the guipure of DWT mesh-belt drier after American Ginseng and ginseng are removed impurity and dis-medicinal part, be dried to moisture in 60 ~ 70 DEG C and be no more than 9.0%.
4. the preparation method of a kind of health food of develop immunitypty according to claim 2, it is characterized in that, also comprise demulcen step: put into medicine-washing machine after the red sage root being removed impurity and dis-medicinal part and wash away silt, then load in clean plastic crate, demulcen 15 ~ 20h, makes red rooted salvia soften, and the red sage root softened is cut into short section of 5 ~ 10mm, load on the guipure of DWT mesh-belt drier, be dried to moisture in 60 ~ 70 DEG C and be no more than 9.0%.
5. the preparation method of a kind of health food of develop immunitypty according to claim 2, it is characterized in that, the sterilising conditions described in step (1) is: ultraviolet sterilization 30mi n, ozone sterilization 180mi n.
6. a kind of preparation method of health food of develop immunitypty according to any one of claim 2 to 5, it is characterized in that, step (2) arranges to obtain dry particle, adds silica and mixes, and obtains total mixture material; By above-mentioned total mixture in dust proof workshop, with automatic tire bagger dress capsule, polishing, bottled, sealing, packaging, product inspection, warehouse-in.
7. the preparation method of a kind of health food of develop immunitypty according to claim 2, it is characterized in that, step (1) American Ginseng, the red sage root and ginseng carry out primary comminution respectively and cross 80 mesh sieves.
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| CN105125635A (en) * | 2015-10-12 | 2015-12-09 | 上海中医药大学 | Traditional Chinese medicine composition capable of boosting immunity and application thereof |
| CN105614852A (en) * | 2015-12-25 | 2016-06-01 | 康美（北京）药物研究院有限公司 | Health-care composition with cordyceps sinensis and preparing method thereof |
| CN106820112A (en) * | 2016-12-23 | 2017-06-13 | 长春豪顿科技有限公司 | One kind mitigates flue gas harm composition, food or health products and preparation method thereof |
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| KR20050043881A (en) * | 2005-04-27 | 2005-05-11 | 김성호 | A herb extract |
| CN1883528A (en) * | 2006-06-06 | 2006-12-27 | 吉林省宏久生物科技股份有限公司 | Chinese medicine extracts for improving immunity and treating human and animal influenza |
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| CN105125635A (en) * | 2015-10-12 | 2015-12-09 | 上海中医药大学 | Traditional Chinese medicine composition capable of boosting immunity and application thereof |
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| CN106820112A (en) * | 2016-12-23 | 2017-06-13 | 长春豪顿科技有限公司 | One kind mitigates flue gas harm composition, food or health products and preparation method thereof |
| CN106820112B (en) * | 2016-12-23 | 2020-11-17 | 长春豪顿科技有限公司 | Composition, food or health product for reducing smoke harm and preparation method thereof |
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| CN104489684B (en) | 2017-07-25 |
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