CN1883528A - Chinese medicine extracts for improving immunity and treating human and animal influenza - Google Patents
Chinese medicine extracts for improving immunity and treating human and animal influenza Download PDFInfo
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- CN1883528A CN1883528A CN 200610083851 CN200610083851A CN1883528A CN 1883528 A CN1883528 A CN 1883528A CN 200610083851 CN200610083851 CN 200610083851 CN 200610083851 A CN200610083851 A CN 200610083851A CN 1883528 A CN1883528 A CN 1883528A
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Abstract
The invention discloses a Chinese medicinal preparation whose active constituents include ginseng extracts extracted from ginseng and/or American ginseng leaves and/or extract of American ginseng leaves polysaccharides. The invention also discloses the process for extracting gen-seng and American ginseng leaves polysaccharides, which comprises the steps of water extraction, macropore resin adsorption, alcohol depositing and drying.
Description
Technical field
The present invention relates to the Chinese medicine extract of a kind of people of treatment and animal influenza, raising immunity.
Background technology
Along with developing by leaps and bounds of medical science technology, the most acute infectious disease in the world today have obtained effective control, people's number average of dying from blood circulation diseases and tumor has now risen to first or second, World Health Organization (WHO) classifies it as among the primary control category, causes domestic and international medical scholar's great attention.
In recent years China medicine worker to the stem and leaf of Radix Ginseng, Radix Panacis Quinquefolii aerial parts carried out a large amount of, widely, aspect researchs such as the chemical constituent of system and pharmacologically active, obtained bigger achievement.
But the extracting method of Radix Ginseng, stem and leaf of Radix Panacis Quinquefolii polysaccharide and application thereof also are not seen in report.
Summary of the invention
The technical issues that need to address of the present invention just are to overcome the defective of prior art, and the Chinese medicine extract of a kind of people of treatment and animal influenza, raising immunity is provided.
For addressing the above problem, the present invention adopts following technical scheme:
The present invention is a kind of to treat the Chinese medicine extract of people and animal influenza, raising immunity, the contained active component of described Chinese medicine extract is that the extracting method of Radix Ginseng, stem and leaf of Radix Panacis Quinquefolii polysaccharide comprises the following steps: by Radix Ginseng and/or the Radix Ginseng of stem and leaf of Radix Panacis Quinquefolii extraction and/or the extract of stem and leaf of Radix Panacis Quinquefolii polysaccharide
1), water extraction
2), macroporous resin adsorption
3), precipitate with ethanol
4), drying.
Water extraction step of the present invention is: Radix Ginseng or stem and leaf of Radix Panacis Quinquefolii are decocted with water, and the addition of water is 15 times of amounts of medicine material weight, and 100 ℃ were extracted 3-4 hour, after the centrifugal filtration filtrate were concentrated into the extractum of 80 ℃ of following relative densities 1.30.
Macroporous resin adsorption step of the present invention is: doubly measure neutral or weakly alkaline macroporous resin adsorption with 3-5 described extractum, collect feed liquid by resin column, filter, concentrate concentrated solution.
Precipitate with ethanol step of the present invention is: with the concentrated solution weight concentration is that 95% ethanol carries out precipitate with ethanol 4 times, and the ethanol weight concentration of at every turn transferring concentrated solution is 85%, and the precipitate with ethanol time is 12 hours, precipitation, filter precipitate.
Drying steps of the present invention is: precipitate being dissolved in water and being diluted to suitable density is 1.09-1.12, carries out spray drying.
The dosage form of Chinese medicine extract of the present invention can be powder, and it can treat people and animal influenza, raising animal body immunity.Usage and dosage: every day the 2g active substance, take after mixing it with water with warm water.
The present invention extracts the polysaccharide in Radix Ginseng, the stem and leaf of Radix Panacis Quinquefolii, is developed to a kind of new Chinese medicine preparation that can treat viral influenza, improve animal body immunity.
Radix Ginseng, stem and leaf of Radix Panacis Quinquefolii immuno-modulating effect of polysaccharides are treated viral influenza.
Radix Ginseng, stem and leaf of Radix Panacis Quinquefolii polysaccharide can significantly strengthen the function of mononuclear phagocyte system.Gavage GPS 1 time by various dose to white mice every day, successive administration 3 times, and 24h carries out phagocytic function mensuration after the last administration, and GPS can obviously increase the phagocytic index of macrophage as a result.GPS can enhancing antibody and the formation of complement, can significantly increase the content of SC and serum IgG.GPS is to the effect of immune organ, and behind the injected in mice GPS, spleen and thymic weight significantly increase than matched group.
The beneficial effect of the inventive method is: technology is simple, the extract purity height, and the Stem and leaf of Radix Ginseng polyoses content of extraction reaches more than 30%.
The specific embodiment
Embodiment 1
1, Stem and leaf of Radix Ginseng is decocted with water, the addition of water is 15 times of amounts of medicine material weight, and 100 ℃ were extracted 3-4 hour, after the centrifugal filtration filtrate were concentrated into the extractum of 80 ℃ of following relative densities 1.30.
2, described extractum is doubly measured neutral or weakly alkaline macroporous resin adsorption with 3-5, collect feed liquid, filter, concentrate by resin column.
3, be that 95% ethanol carries out precipitate with ethanol 4 times with the concentrated solution weight concentration, the ethanol weight concentration of at every turn transferring concentrated solution is 85%, and the precipitate with ethanol time is 12 hours, precipitation, filter precipitate.
4, precipitate being dissolved in water and being diluted to suitable density is 1.09-1.12, carries out spray drying, gets the Stem and leaf of Radix Ginseng polyoses extract.
5, extract is prepared into Chinese powder medicine.
Embodiment 2
1, stem and leaf of Radix Panacis Quinquefolii is decocted with water, the addition of water is 15 times of amounts of medicine material weight, and 100 ℃ were extracted 3-4 hour, after the centrifugal filtration filtrate were concentrated into the extractum of 80 ℃ of following relative densities 1.30.
2, described extractum is doubly measured neutral or weakly alkaline macroporous resin adsorption with 3-5, collect feed liquid, filter, concentrate by resin column.
3, be that 95% ethanol carries out precipitate with ethanol 4 times with the concentrated solution weight concentration, the ethanol weight concentration of at every turn transferring concentrated solution is 85%, and the precipitate with ethanol time is 12 hours, precipitation, filter precipitate.
4, precipitate being dissolved in water and being diluted to suitable density is 1.09-1.12, carries out spray drying, gets the stem and leaf of Radix Panacis Quinquefolii polyoses extract.
5, extract is prepared into Chinese powder medicine.
Embodiment 3 methods of inspection (ultraviolet spectrophotometry):
1, the preparation of standard solution: precision takes by weighing galacturonic acid reference substance 100mg, puts in the 100ml volumetric flask to be dissolved in water, and is diluted to scale, shakes up, and precision is measured 10ml again, puts in the 100ml measuring bottle, is dissolved in water and is diluted to scale, shakes up promptly.
2, the preparation of test solution: the extract 50mg that precision takes by weighing embodiment 1 or embodiment 2 preparations, put in the 100ml volumetric flask, be dissolved in water and be diluted to scale, shake up promptly.
3, assay method: precision is measured need testing solution 1ml, distilled water 1ml, place the 10ml volumetric flask respectively, add concentrated sulphuric acid 6ml respectively, put in the water-bath and heated 20 minutes, cooling, add 0.1% carbazole dehydrated alcohol 0.2ml more respectively, put in the boiling water bath 10 minutes, in water-bath, cool off, thin up shakes up to scale.Measure the trap of need testing solution at 530nm wavelength place.Calculate promptly.
Stem and leaf of Radix Ginseng polyoses content (in the D-galacturonic acid) is 32.10% in the finished product of the embodiment of the invention 1 preparation, and stem and leaf of Radix Panacis Quinquefolii polyoses content (in the D-galacturonic acid) is 32.22% in the finished product of embodiment 2 preparations.
Embodiment 4 cures example and curative effect
Product of the present invention can be treated people and animal influenza, human body immunity improving power, case 238 examples, and cure rate is 68%, effective percentage 89%, inefficiency is 11%.
The present invention is not limited to above-mentioned preferred forms, and other any identical with the present invention or akin products that anyone draws under enlightenment of the present invention all drop within protection scope of the present invention.
Claims (7)
1, a kind of Chinese medicine extract for the treatment of people and animal influenza, raising immunity, it is characterized in that the contained active component of described Chinese medicine extract is that the extracting method of described Radix Ginseng, stem and leaf of Radix Panacis Quinquefolii polysaccharide comprises the following steps: by Radix Ginseng and/or the Radix Ginseng of stem and leaf of Radix Panacis Quinquefolii extraction and/or the extract of stem and leaf of Radix Panacis Quinquefolii polysaccharide
1), water extraction
2), macroporous resin adsorption
3), precipitate with ethanol
4), drying.
2, the Chinese medicine extract of treatment people as claimed in claim 1 and animal influenza, raising immunity, it is characterized in that described water extraction step is: Radix Ginseng or stem and leaf of Radix Panacis Quinquefolii are decocted with water, the addition of water is 15 times of amounts of medicine material weight, 100 ℃ were extracted 3-4 hour, after the centrifugal filtration filtrate were concentrated into the extractum of 80 ℃ of following relative densities 1.30.
3, as the Chinese medicine extract of treatment people and animal influenza, raising immunity as described in the claim 2, it is characterized in that the macroporous resin adsorption step is: described extractum is doubly measured neutral or weakly alkaline macroporous resin adsorption with 3-5, collection is by the feed liquid of resin column, filter, concentrate, get concentrated solution.
4, the Chinese medicine extract of treatment people as claimed in claim 3 and animal influenza, raising immunity, it is characterized in that described precipitate with ethanol step is: with the concentrated solution weight concentration is that 95% ethanol carries out precipitate with ethanol 4 times, the ethanol weight concentration of each accent concentrated solution is 85%, the precipitate with ethanol time is 12 hours, the precipitation, filter precipitate.
5, the Chinese medicine extract of treatment people as claimed in claim 3 and animal influenza, raising immunity, it is characterized in that drying steps is: precipitate being dissolved in water and being diluted to suitable density is 1.09-1.12, carries out spray drying.
6, the Chinese medicine extract of treatment people as claimed in claim 5 and animal influenza, raising immunity, it is characterized in that: described extract is a powder.
7, the application of the Chinese medicine extract of treatment as claimed in claim 6 people and animal influenza, raising immunity is characterized in that it can treat viral influenza, improve animal body immunity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610083851 CN1883528A (en) | 2006-06-06 | 2006-06-06 | Chinese medicine extracts for improving immunity and treating human and animal influenza |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610083851 CN1883528A (en) | 2006-06-06 | 2006-06-06 | Chinese medicine extracts for improving immunity and treating human and animal influenza |
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| CN1883528A true CN1883528A (en) | 2006-12-27 |
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| CN 200610083851 Pending CN1883528A (en) | 2006-06-06 | 2006-06-06 | Chinese medicine extracts for improving immunity and treating human and animal influenza |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101157731B (en) * | 2007-11-06 | 2012-05-30 | 吉林省宏久生物科技股份有限公司 | Preparation method for low agriculture remanet panax ginseng and American ginseng polysaccharide extractive |
| CN104489684A (en) * | 2015-01-06 | 2015-04-08 | 康美（北京）药物研究院有限公司 | Healthcare food capable of enhancing immunity and preparation method of healthcare food |
| CN104523786A (en) * | 2014-05-18 | 2015-04-22 | 抚松县安东参业有限公司 | Preparation method and application of ginseng stem and leaf non-saponin water-soluble extract |
-
2006
- 2006-06-06 CN CN 200610083851 patent/CN1883528A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101157731B (en) * | 2007-11-06 | 2012-05-30 | 吉林省宏久生物科技股份有限公司 | Preparation method for low agriculture remanet panax ginseng and American ginseng polysaccharide extractive |
| CN104523786A (en) * | 2014-05-18 | 2015-04-22 | 抚松县安东参业有限公司 | Preparation method and application of ginseng stem and leaf non-saponin water-soluble extract |
| CN104523786B (en) * | 2014-05-18 | 2018-01-09 | 抚松县安东参业有限公司 | The preparation method and applications of the non-saponin(e water-soluble extractive of gen-seng haulms |
| CN104489684A (en) * | 2015-01-06 | 2015-04-08 | 康美（北京）药物研究院有限公司 | Healthcare food capable of enhancing immunity and preparation method of healthcare food |
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