CN108740305A - Special calcium tablet of Diseases of Cow and preparation method thereof - Google Patents
Special calcium tablet of Diseases of Cow and preparation method thereof Download PDFInfo
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- CN108740305A CN108740305A CN201810444459.9A CN201810444459A CN108740305A CN 108740305 A CN108740305 A CN 108740305A CN 201810444459 A CN201810444459 A CN 201810444459A CN 108740305 A CN108740305 A CN 108740305A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
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Abstract
The special calcium tablet of milk cow proposed by the present invention, including calcium ion, vitamin, sucrose and starch, it further includes saturated fatty acid, zeolite powder and spirulina, and the weight percent of component described above is：Calcium ion 50-60%, vitamin 2-5%, sucrose 5-10%, starch 6-12%, saturated fatty acid 5-10%, zeolite powder 3-6%, spirulina 15-20%；Coating of the saturated fatty acid as calcium tablet.Blood calcium concentration increases after the present invention can prevent antenatal milk cow from eating calcium tablet influences very much milk cow itself calcium regulating power and can improve milk cow immunity soon, and prevents and treats the parturient paresis caused by low blood calcium of milk cow postpartum.
Description
Technical field
The present invention relates to special calcium tablets of a kind of Diseases of Cow and preparation method thereof.
Background technology
The metabolic balance of calcium includes mainly taking in calcium from feed and two approach of calcium being discharged to external in Contents in Cows.Once
Balance is broken, and may result in Plasma Ca excessive concentration or too low, is easily caused such as osteoporosis, osteodysplasty, production
The illnesss such as paralysis.After cow birth, often blood calcium concentration drastically reduces caused by lactation, is not only easy to cause parturient paresis, also
Possible secondary ketosis of dairy cows, fore-stomach stony and other postpartum diseases, heavy losses are caused to milk cow production.
Milk cow calcium-supplementing preparation type currently on the market is various, main component be calcium lactate, calcium carbonate, calcium gluconate,
The common feature of calcium citrate etc., these ingredients is that intestinal absorption rate is low, and poor bioavailability, usage amount is big, therefore, replenishes the calcium
Effect is not highly desirable.Dosage form is that the oral liquid process such as conventional tablet, oral solution are cumbersome, of high cost, conventional tablet dissolving
Property is bad etc..
By not influenced by microorganism and digestive juice when ox stomach chemistry does not occur for amino acid chelated calcium, good water solubility
Variation, but directly absorbed by amino acid special modality in enteron aisle, infiltration rate is fast, and absorptivity in vivo is up to
82% or more.
It keeps solid state under saturated fatty acid room temperature, and does not dissolve in rumen fluid, absorption is digested in small enteral, it can be with
Milk cow plant recovery of nutrient is improved, body condition is improved, increases the resistance to disease.
Invention content
In order to overcome the above problem, blood calcium concentration increases after can preventing antenatal milk cow from eating calcium tablet the present invention provides one kind
Milk cow itself calcium regulating power is influenced very much soon and can improve milk cow immunity, and prevents and treats milk cow postpartum because low blood calcium causes
The special calcium tablet of Diseases of Cow of parturient paresis and preparation method thereof.
To solve the above-mentioned problems, the present invention uses following technical scheme：A kind of special calcium tablet of Diseases of Cow, including calcium
Ion, vitamin, sucrose and starch, it further includes saturated fatty acid, zeolite powder and spirulina,
The weight percent of component described above is：Calcium ion 50-60%, vitamin 2-5%, sucrose 5-10%, starch
6-12%, saturated fatty acid 5-10%, zeolite powder 3-6%, spirulina 15-20%；
Coating of the saturated fatty acid as calcium tablet.
Further, the weight percent of each component is：Calcium ion 55%, vitamin 3%, sucrose 7%, starch
9%, saturated fatty acid 6%, zeolite powder 4%, spirulina 16%.
Further, it is 1 that the calcium ion, which includes weight ratio,：9：1 ionic organic calcium, sequestering organic calcium and inorganic
Calcium.
Further, it is 1 that the vitamin, which includes weight ratio,：1：1 vitamin A, vitamin C and vitamin E.
Preferably, the saturated fatty acid is one in stearic acid, the brown oleic acid for putting acid or hydrogenation, linoleic acid plus linolenic acid
Kind is a variety of.
Preferably, the sucrose uses brown sugar.
A method of the special calcium tablet of above-mentioned Diseases of Cow is prepared, is included the following steps：
(1) by amino acid chelated calcium, calcium sulfate, calcium lactate, vitamin A, vitamin C, vitamin E zeolite powder, spirulina,
Sugarcane sugar and starch each component crushes, all it is logical sieve with 100 mesh sieve it is spare；
(2) amino acid chelated calcium, calcium sulfate, calcium lactate, vitamin A, vitamin C, vitamin E, boiling are proportionally weighed
Mixing after mountain flour, spirulina, sugarcane sugar and starch each component will successively be pelletized after mixture of powders plus water, be dried, whole grain；
(3) it will be coated up to the special calcium tablet of milk cow using saturated fatty acid after the particle prepared tabletting machine.
Beneficial effects of the present invention are as follows：
The present invention is for preventing and treating ox acalcicosis, such as osteoporosis, osteodysplasty, pregnancy milk cow and lactation period
The supplement of milk cow calcium employs the calcium in bone and promotes the suction of calcium by adjusting calcium phosphorus ration, activation body parathyroid gland function
It receives, prevents and treats the prevention etc. of milk cow postpartum postpartum paralysis caused by low blood calcium, and milk cow immunity can be improved.The present invention
Simple for process, easy to use, bioavilability is high, and stability is strong.
Antenatal less to calcium requirement according to Diseases of Cow physilogical characteristics, postpartum since a large amount of calcium are lost in lactation, needs
Rapid to increase blood calcium, the present invention effectively prevents the low blood calcium of Diseases of Cow and postpartum paralysis, and amino acid chelated calcium has to be sequestering
Machine calcium has the advantages that dissolubility is good, absorptivity is high, has no toxic side effect, most of to be absorbed in small intestine, and milk cow is complex stomach animal,
It is longer in the Gastric retention time after this edible calcium tablet, slow releasing function is played, can prevent antenatal milk cow from eating blood calcium concentration after calcium tablet
Increase influences very much milk cow itself calcium regulating power soon.Calcium lactate is ionic organic calcium, easily absorbs, is water-disintegrable good, inhaling in vivo
Receipts speed is faster than amino acid chelated calcium, this calcium tablet can be such that blood calcium slowly increases after taking, and meet need of the cow in perinatal period to calcium
It wants, plays the role of good prophylactic treatment.
Solid state is kept under saturated fatty acid room temperature, and does not dissolve in rumen fluid, and absorption, this calcium tablet are digested in small enteral
It is longer in the Gastric retention time after being coated using saturated fatty acid, slow releasing function is played, saturated fatty acid can improve milk cow and support
Divide utilization rate, improve body condition, increases the resistance to disease.Saturated fatty acid other than it can improve milk cow plant recovery of nutrient,
Fine fodder scale of feeding can be also effectively reduced, cow rumen acid poisoning risk is reduced, improves Cow product, reproductive performance.
There are interaction relationship, spirulina individually to play its effect between zeolite powder and other components；In this formula, zeolite
Powder and spirulina are indispensable, and reason is as follows：
The zeolite powder that the present invention selects, it is cheap, and there is adsorptivity and Selective adsorption, reversible ion exchange
Property, absorption enteron aisle in poisonous and harmful metabolite the advantages that, also have certain inhibiting effect to the pernicious bacteria in animal intestinal tract,
And there is special suction-operated to certain heavy metals, eliminate, mitigate or inhibit the venomous injurants such as mould and heavy metal to verify dynamic
The toxic action of object, thus the incidence of animal can be reduced and improved food conversion ratio, improve the output of milk.
But zeolite powder can reduce butterfat percnetage, therefore, the present invention selects saturated fatty acid to make Lipid sources, and spirulina is made
Protein source；Zeolite molecules structure belongs to opening, has many uniform cavitys, intracavitary that can store Ca2+、Mg2+Equal gold
Belong to cation, calcium tablet can be extended in the residence time in the digestive tract, slow releasing function is played, reduce production cost, improve animal
Production performance and economic benefit.
Spirulina is easily absorbed containing abundant protein (60%), fat, multivitamin, and cheap, source is wide, has
It is antifatigue, increase the output of milk, improve butterfat percnetage, the effects that strengthen immunity, calcium tablet palatability also can be improved, prevent anaemia, change
Kind Rumen Internal Environment, promotes rumen bacteria synthesising thalli protein, improves crude fiber digestibility.
Specific implementation mode
The special calcium tablet of Diseases of Cow of the present invention is the component using weight percent：Calcium ion 50-60%, vitamin
2-5%, sucrose 5-10%, starch 6-12%, saturated fatty acid 5-10%, zeolite powder 3-6%, the component of spirulina 15-20%,
By calcium ion, vitamin, zeolite powder, spirulina, sucrose, starch is prepared by mixing into particle calcium tablet, finally on particle calcium tablet surface
Coating saturated fatty acid forms.Specific embodiment is as follows：
Case study on implementation 1
Calcium ion selects amino acid chelated calcium, calcium sulfate and calcium lactate.
Vitamin selects vitamin A, vitamin C and vitamin E.
Saturated fatty acid selects the oleic acid and stearic acid of hydrogenation.
Sucrose selects brown sugar.
According to weight percent：Calcium ion 55% (amino acid chelated calcium 45%, calcium sulfate 5%, calcium lactate 5%), saturation
Aliphatic acid 6%, vitamin 3% (vitamin A 1%, vitamin C 1%, vitamin E 1%), zeolite powder 4%, spirulina
16%, brown sugar 7% and starch 9% weigh 90 grams of amino acid chelated calcium, 10 grams of calcium sulfate, 10 grams of calcium lactate, saturated fatty acid 12
Gram, 2 grams of vitamin A, Catergen gram, 2 grams of vitamin E, 8 grams of zeolite powder, 32 grams of spirulina, 14 grams of brown sugar and starch 18
Gram.
Specific preparation process is as described below：
(1) by amino acid chelated calcium, calcium sulfate, calcium lactate, vitamin A, vitamin C, vitamin E, zeolite powder, spiral
Algae, brown sugar, starch each component crush, all logical to sieve with 100 mesh sieve, spare.
(2) it prepares particle and proportionally weighs amino acid chelated calcium, calcium sulfate, calcium lactate, vitamin A, vitamin C, dimension
Raw element E, zeolite powder, spirulina, brown sugar, starch each component use water with weight incremental method mixing after forming homogeneous powder mixture
It as adhesive, is proportionally added with above-mentioned mixture of powders, prepares softwood, granulation, drying, whole grain.
(3) saturated fatty acid will be coated after the particle tabletting machine prepared up to a kind of special calcium tablet of milk cow.
Case study on implementation 2
Calcium ion selects amino acid chelated calcium, calcium sulfate and calcium lactate.
Vitamin selects vitamin A, vitamin C and vitamin E.
Saturated fatty acid selects palm fibre to put acid and leukotrienes.
Sucrose selects brown sugar.
According to weight percent：Calcium ion 51.7% (amino acid chelated calcium 42.3%, calcium sulfate 4.7%, calcium lactate
4.7%), saturated fatty acid 8% (palm fibre puts acid 4% and leukotrienes 4%), vitamin 3.3% (vitamin A 1.1%, vitamin C
1.1%, vitamin e1 .1%), zeolite powder 3%, spirulina 17%, brown sugar 5% and starch 12% weigh amino acid chelated calcium
84.6 grams, 9.4 grams of calcium sulfate, 9.4 grams of calcium lactate, palm fibre puts sour 8 grams, 8 grams of leukotrienes, 2.2 grams of vitamin A, Catergen .2
Gram .2 grams of vitamin E2,6 grams of zeolite powder, 34 grams of spirulina, 24 grams of 10 grams of brown sugar and starch.
Specific preparation process is as described below：
(1) by amino acid chelated calcium, calcium sulfate, calcium lactate, vitamin A, vitamin C, vitamin E, zeolite powder, spiral
Algae, brown sugar, starch each component crush, all logical to sieve with 100 mesh sieve, spare.
(2) it prepares particle and proportionally weighs amino acid chelated calcium, calcium sulfate, calcium lactate, vitamin A, vitamin C, dimension
Raw element E, zeolite powder, spirulina, brown sugar, starch each component use water with weight incremental method mixing after forming homogeneous powder mixture
As adhesive, with above-mentioned mixture of powders according to water and material 1：20 ratio addition, prepares softwood, granulation, drying, whole grain.
(3) saturated fatty acid will be coated after the particle tabletting machine prepared up to a kind of special calcium tablet of milk cow.
Before the usage cow in perinatal period health care just before giving birth of the present invention, is offerd medicine, daily 1, is used in conjunction 2 days using oral administration medicine supplying device,
In postpartum, 2 tablets once, is used in conjunction 2 days, the health care of cow producing milk peak period, monthly periodically uses, and 2 tablets once, and interval is used for 1 day again, is used in conjunction
2 times.Every weight is 50 grams.
Rapidly dissolving tablet of the present invention is used to prevent and treat the effect observation of Cow product paralysis.Clinical criteria infected cattle attempts
It stands, however its hind leg cannot stretch completely, can only be creeped along ground with two hind legs of portions flex, two hind legs having move back
Position, backbone are bent in " S " type or " C " type.It is dense that laboratory's diagnosis measures blood calcium for suspected case using Atomic absorption luminosity instrument
Degree.
1, prophylactic tria
Experimental animal Qingdao of Shandong province Laixi City dairy village, tests 100 just before giving birth milk cows, wherein 50
2 days calcium tablets are used in conjunction as test group, antenatal in cow head, daily 1.
2, therapeutic test
Experimental animal Qingdao of Shandong province Pingdu City dairy village, the milk cow that 24 hairs are given birth to parturient paresis are tried
It tests, is divided into control group and test group, test group is treated using the calcium tablet of invention, and control group uses calisanin preparation grape
Calciofon, with being drunk after water dissolution.
Separately to having there is the milk cow 12 of parturient paresis, it is divided into control group and test group, test group milk cow is using invention
Calcium tablet is a piece of to be treated, and control group uses calcium gluconate preparation calcium gluconate, with being drunk after water dissolution.Front and back point of medication
Blood calcium concentration is not measured.
3, result
(1) preventive effect：
There is parturient paresis in 3 oxen of control group, and it is respectively 6.3mg/ml, 7.1mg/ml, 6.9mg/ml to measure blood calcium concentration,
Respectively less than normal level milk cow normal blood calcium concentration (8.6mg/ml-11.1mg/ml)；
The no abnormal symptom of test group ox, 8 ox blood samples of sampling Detection, calcium level is all in normal range (NR), respectively
For 8.8mg/ml, 8.3mg/ml, 8.9mg/ml, 9.6mg/ml, 10.3mg/ml, 10.7mg/ml, 10.6mg/ml, 10.2mg/
ml。
(2) therapeutic effect：Control group cure rate is 67%, and the absorptivity of calcium is respectively 31.9%, 32.7%, 31.5%,
35.4%, 39.8%, 33.6%.
Test group cure rate is 92%, the absorptivity difference 91.6%, 94.3%, 92.5%, 93.6%, 90.7% of calcium,
93.1%.
Claims (7)
1. a kind of special calcium tablet of Diseases of Cow, including calcium ion, vitamin, sucrose and starch, which is characterized in that it further includes
Saturated fatty acid, zeolite powder and spirulina,
The weight percent of component described above is：Calcium ion 50-60%, vitamin 2-5%, sucrose 5-10%, starch 6-
12%, saturated fatty acid 5-10%, zeolite powder 3-6%, spirulina 15-20%；
Coating of the saturated fatty acid as calcium tablet.
2. the special calcium tablet of Diseases of Cow according to claim 1, it is characterised in that：The weight percent of each component
For：Calcium ion 55%, vitamin 3%, sucrose 7%, starch 9%, saturated fatty acid 6%, zeolite powder 4%, spirulina 16%.
3. the special calcium tablet of Diseases of Cow according to claim 1, it is characterised in that：The calcium ion includes that weight ratio is
1：9：1 ionic organic calcium, sequestering organic calcium and inorganic calcium.
4. the special calcium tablet of Diseases of Cow according to claim 1, it is characterised in that：The vitamin includes that weight ratio is
1：1：1 vitamin A, vitamin C and vitamin E.
5. the special calcium tablet of Diseases of Cow according to claim 1, it is characterised in that：The saturated fatty acid is tristearin
Acid, palm fibre are put one or more in the oleic acid of acid or hydrogenation, linoleic acid plus linolenic acid.
6. the special calcium tablet of Diseases of Cow according to claim 1, it is characterised in that：The sucrose uses brown sugar.
7. a kind of method of the special calcium tablet of the Diseases of Cow prepared described in any one of claim 1-6, which is characterized in that packet
Include following steps：
(1) by amino acid chelated calcium, calcium sulfate, calcium lactate, vitamin A, vitamin C, vitamin E zeolite powder, spirulina, sucrose
Crushed with starch each component, all it is logical sieve with 100 mesh sieve it is spare；
(2) proportionally weigh amino acid chelated calcium, calcium sulfate, calcium lactate, vitamin A, vitamin C, vitamin E, zeolite powder,
Mixing after spirulina, sugarcane sugar and starch each component will successively be pelletized after mixture of powders plus water, be dried, whole grain；
(3) it will be coated up to the special calcium tablet of milk cow using saturated fatty acid after the particle prepared tabletting machine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111903853A (en) * | 2020-08-11 | 2020-11-10 | 黑龙江八一农垦大学 | Health-care granules for relieving energy metabolism disorder of dairy cows in perinatal period and preparation method thereof |
| CN113693166A (en) * | 2021-08-19 | 2021-11-26 | 浙江万方生物科技有限公司 | Sectional type slow-release mineral element rod special for dairy cows and preparation method thereof |
| CN117461740A (en) * | 2023-11-06 | 2024-01-30 | 中国农业大学 | Mineral element metabolism regulator for preventing postpartum hypocalcemia of dairy cows and application thereof |
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| CN111903853A (en) * | 2020-08-11 | 2020-11-10 | 黑龙江八一农垦大学 | Health-care granules for relieving energy metabolism disorder of dairy cows in perinatal period and preparation method thereof |
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| CN117461740A (en) * | 2023-11-06 | 2024-01-30 | 中国农业大学 | Mineral element metabolism regulator for preventing postpartum hypocalcemia of dairy cows and application thereof |
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| Publication number | Publication date |
|---|---|
| CN108740305B (en) | 2021-09-17 |
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