CN106913856A - A kind of animal specific calcium tablet and preparation method thereof - Google Patents
A kind of animal specific calcium tablet and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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Abstract
The present invention provides a kind of animal specific calcium tablet and preparation method thereof, and following component is included in animal specific calcium tablet described in per 100g：1~10g of calcium ion, 0.1~2g of magnesium ion, 0.1~2g of phosphonium ion, 0.1~1g of CPP, 25 hydroxy-vitamine Ds30.1~0.5g, 0.1~1g of vitamin C, 1~10g of sucrose, 1~3g of sodium alginate, 1~5g of odium stearate, 0~0.1g of Feed Flavourings, remaining is supplied with starch.Animal specific calcium tablet of the invention contains CPP, 25(OH)VD3And vitamin C, can greatly promote animal to calcium, phosphorus, magnesium absorption, bioavilability is higher.Good stability, normal temperature is preserved 3 years, remains to the integrality of holding structure and drug effect.Can be used for larger animal such as ox, horse, pig etc., it can also be used to which such as laying hen, cat etc. orally use meiofauna.
Description
Technical field
The invention belongs to veterinary drug technical field, and in particular to a kind of animal specific calcium tablet and preparation method thereof.
Background technology
Hypocalcemia is the recurrent Nutrition and Metabolism disease of the livestock and poultry such as milk cow, horses, sow, dog, laying hen, the disease with
It is principal character that blood calcium reduction, smooth muscle contraction weaken, and the sleeping ground of livestock and poultry can be caused not rise, go into a coma or even dead when serious.Most
Nearly more than 20 years, people just progressively by livestock and poultry paralysis with blood calcium reduce connect, and by supplement calcium, vitamin D and magnesium from
The methods such as son are prevented and treated.
At present, the preventing and treating domestic animal most common method of low blood calcium is oral calcium tonic, next to that venoclysis is replenished the calcium.According to state
The result of family's veterinary drug Information Network inquiry, the oral calcium tonic of animal specific only has phosphoric acid hydrogen calcium tablet a kind of, and transfusion calcium tonic only has
Three kinds of calcium gluconae, calcium chloride and caclium diborogluconate.According to the data that CFAD is inquired about, people is criticized with the drug class orally replenished the calcium
Text has more than 30, and the product of listing is even more more than 500 kinds, animal orally replenish the calcium medicine and people it is fresh with being formd between medicine of orally replenishing the calcium
Bright quantitative comparison.The calcareous shortage of foodstuff animal will result in the calcium deficiency in the food such as meat, egg, milk, long-term consumption
This based food, must produce a very large impact to the calcareous supplement of human body.Therefore, novel high-quality animal specific calcium tonic is researched and developed, for
Improve animal, the particularly constitution of foodstuff animal and its product is significant.
Calcium monohydrogen phosphate belongs to inorganic calcium, and it is digested and assimilated and is extremely limited.Calcium gluconae solubility in water is low,
10% calcium gluconate injection has reached maximum saturation, for heavy livestock such as milk cow, it is necessary to disposable infusion 1000-
Just effectively, and after transfusion 12 hours, blood calcium is most of to discharge 2000ml with urine, and the state of an illness is easily repeatedly.For laying hen, dog,
The animals such as cat are to be difficult to use this kind of large-scale transfusion calcium tonic.
There are document and patent report to prepare for animals iv calcium tonic and oral administration solution, such as：Lee's spectrum China exists《Boron grape
The development of Calciofon parenteral solution and electuary》In, it was recently reported that the preparation method and formula of a kind of caclium diborogluconate, but match somebody with somebody at this
Calcium gluconae and boric acid simply are used in side, the addition of phosphonium ion has been have ignored and is used.The formula cannot in Clinical practice
Supplement and coordinative role while calcium phosphorus are realized, and the pH value of preparation only has 5.0, thorn of such low pH value to animal body
Swash very big, easily cause acid poisoning.Patent《Calcic, phosphorus, magnesium or calcium, phosphorus Injection for animals and preparation method thereof》(ZL
A kind of calcic, phosphorus, the preparation method of magnesium Injection for animals, but the patent are reported in 200310118939X) not to being invented
Product carry out the case study on implementation of study on the stability and clinical practice, therefore the reasonability and practical application of its formula cannot be judged
Effect.Patent《A kind of calcium borogluconate solution and preparation method thereof》(Authorization Notice No. CN103191053B) elaborates one kind
The preparation method of calcium borogluconate solution for oral use, the maximum uncontrollable oral dose of defect of oral calcium tonic, and orally
The time that calcium tonic afterwards is metabolized in vivo is very fast.Patent《A kind of aquaculture vigor ion calcium tablet》(application number
201410663293.1) it is a kind of calcium tablet for aquatic product cultivation, is not suitable for terricole and replenishes the calcium.
Therefore, to overcome the defect and deficiency of the said goods, it is necessary to invent a kind of new animal specific calcium tonic, it is used for
Preventing and treating animal hypocalcemia.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of animal specific calcium tablet and preparation method thereof, for preventing and treating animal
Hypocalcemia, calcium content is high, stability is strong, drug effect is permanent, can both make larger particles and replenished the calcium for heavy livestocks such as milk cows,
Minipill can also be prepared into, be replenished the calcium for meiofaunas such as laying hen, cats.
In order to solve the above technical problems, embodiments of the invention provide a kind of animal specific calcium tablet, animal described in per 100g
Following component is included in special calcium tablet：
Preferably, following component is included in animal specific calcium tablet described in every 100g：
Further, following component is included in animal specific calcium tablet described in every 100g：
Wherein, the calcium ion includes following component by weight percentage：
Ionic organic calcium 50%
Sequestering organic calcium 40%
Inorganic calcium 10%.
Preferably, the ionic organic calcium be calcium gluconae, calcium malate, calcium lactate, calcium acetate, calcium citrate,
One or more mixture in calcium maleate and glucurone calcium；The chelating type organic calcium be l threonic acid,
One or more mixture in asparagus amino-acid calcium, amino acid chelated calcium and trihydroxy-butyric acid calcium；The inorganic calcium is propionic acid
One or more mixture in calcium, calcium sulfate, calcium chloride and calcium phosphate.
Preferably, the magnesium ion be magnesium L-aspartate, magnesium gluconate and magnesium sulfate in one or more mix
Compound.
Preferably, the phosphonium ion is trinosin, disodium hydrogen phosphate, dibastic sodium phosphate, sodium phosphate, biphosphate
One or more mixture in potassium, potassium hydrogen phosphate and potassium phosphate.
Preferably, the species of the Feed Flavourings is including the Feed Flavourings for pig, the Feed Flavourings for cat, for dog
Feed Flavourings and the Feed Flavourings for chicken, wherein, for pig Feed Flavourings include flavoring apple essence, strawberry essence and
Milk flavour；Feed Flavourings for cat include fish flavour essence, milk flavour and beef flavor；Feed Flavourings for dog include
Milk flavour, beef flavor, chicken essence and coffee aroma；Feed Flavourings for chicken include garlic flavoring.
The embodiment of the present invention also provides a kind of preparation method of above-mentioned animal specific calcium tablet, comprises the following steps：
(1) screen：Raw material described in prescription is utilized respectively into the mesh screen that aperture is 0.3~0.5mm to be screened, the lower original of sieve
Material is used as calcium tablet raw material for standby；
(2) material powder of calcium ions, magnesium ion and phosphonium ion is weighed according to recipe quantity, is placed in three-dimensional mixer,
Fully mix；
(3) CPP, 25- carboxyl vitamin Ds are sequentially added to the mixture of step (2) according to recipe quantity3With
Microbial biomass C, fully mixes；
(4) sucrose, sodium alginate, odium stearate and feed are sequentially added in the mixture according to recipe quantity to step (3)
Essence, fully mixes；
(5) starch is added in the mixture according to recipe quantity to step (4), is fully mixed；
(6) mixed powder mixed in step (5) is transferred in tablet press machine, carries out compressing tablet；
(7) calcium tablet that will be pressed, is transferred in sterile packaging bottle, closed preservation, and animal specific calcium tablet is prepared and completed.
Above-mentioned technical proposal of the invention has the beneficial effect that：
1st, calcium ion of the invention is closed by ionic organic calcium, three kinds of different calcium agents of chelating type organic calcium and inorganic calcium
Reason prescription, its bioactivity and the more existing inorganic type ionized calcium of security are higher, i.e., can quickly supplement calcium, can slowly release again
Calcium is put, the effective calcium-supplement time is most long up to 3 days.
2nd, animal specific calcium tablet of the invention contains CPP, 25(OH)VD3And vitamin C, Neng Gou great
It is big promote animal to calcium, phosphorus, magnesium absorption, bioavilability is higher.
3rd, animal specific calcium tablet good stability prepared by preparation method of the invention is installed, normal temperature is preserved 3 years, remains to keep
The integrality of structure and drug effect.
4th, animal specific calcium tablet of the invention is that can be used for larger animal such as ox, horse, pig etc., it can also be used to which meiofauna is such as
Laying hen, cat etc. orally use.
5th, animal specific calcium tablet of the invention is adapted to conform with the workshop of GMP standards and carries out industrialized production.
Specific embodiment
To make the technical problem to be solved in the present invention, technical scheme and advantage clearer, implement below in conjunction with preparing
The present invention will be described in detail for example, investigation embodiment and clinical pharmacy embodiment.
Embodiment 1
(1) it is respectively the mesh screen of 0.5mm by aperture by each raw material, following preparations is carried out using the raw material by mesh screen；
(2) calcium ion 5g (its ionic organic calcium amount 2.5g, chelating type organic calcium amount 2g and inorganic are measured according to prescription
Calcium 0.5g) add three-dimensional mixer；Magnesium ion 1g is added according to recipe quantity, phosphonium ion 1g is added according to recipe quantity, mix 10 points
Clock；
(3) 0.7g CPPs, 0.3g25- hydroxyls are sequentially added in the mixture according to recipe quantity to step (2)
Vitamin D3With 0.5g vitamin Cs, mix 15 minutes；
(4) 5g sucrose, 1.5g sodium alginates, 3g stearic acid are sequentially added in the mixture according to recipe quantity to step (3)
Sodium and 0.06g milk flavours, mix 20 minutes；
(5) starch to 100g is added in the mixture according to recipe quantity to step (4), is mixed 30 minutes；
(6) mixed powder mixed in step (5) is transferred in tablet press machine, carries out compressing tablet；
(7) calcium tablet that will be pressed, is transferred in sterile packaging bottle, closed preservation, obtains final product animal specific calcium tablet of the present invention,
The entitled G1 of sample.
It should be pointed out that incorporation time is not limited to combinations thereof in above-mentioned steps (2) to (5), can be entered according to actual conditions
Row change, it is desirable to which the material in per step is sufficiently mixed uniformly.
Embodiment 2
According to the preparation technology and flow of embodiment 1, sample G2 and G3 are prepared.Wherein, the component and proportioning of G2 and G3 are shown in
Following table one.
Table one：Prepare the formula of G2 and G3
Embodiment 3
Study on the stability is carried out to sample G1, G2 and G3, method is as follows：
Each 10 bottles of sample G1, G2 and G3 is taken, 100 every bottle, every 3g is placed in 40 DEG C of ± 2 DEG C of temperature and 75%RH ± 5%
Under RH humidity, sealing respectively is placed 6 months, 12 months, 24 months and 36 months, observes proterties, disintegration time limited and the calcium of sample
Content, as a result such as following table two.
Table two：The proterties of sample G1, G2 and G3, disintegration time limited and calcium content
Be can be seen that according to made animal specific calcium tablet sample G1, G2 and G3 stability of the present invention by data in table two
Good, in stability and long-term experiment, proterties, disintegration time limited and calcium content meet the requirements, and illustrate that the invention products obtained therefrom is steady
It is qualitative good.
Embodiment 4
Sample G1, G2 and G3 are taken, it is oral to Postpartum Cows, observe the postpartum paralysis incidence of disease.Specific implementation is as follows：
Scale pasture Postpartum Cows only 100 are taken, is divided into 4 groups, every group 25, first group is group of not taking medicine, and milk cow removes
Outside feed, calcium agent is not supplemented additionally；2-4 groups are set to G1, G2 and G3 group, and milk cow distinguishes oral supplementation G1, G2 and G3 in addition to feed
Sample, every 200g is used in conjunction 2 days.In observation one week, ox quantity of paralysing, as a result such as table three.
Table three：The prevention situation that calcium tablet is paralysed to Postpartum Cows
By data in table three can be seen that it is no in G1 groups milk cow one week paralyse, the paralysis of G2 and G3 groups milk cow is fallen ill
Rate illustrates that inventive samples have good effect for preventing milk cow to produce the paralysis in one week after also far below a group milk cow of not taking medicine
Really, wherein the effect of G1 is better than G2 and G3.
Embodiment 5
Sample G1, G2 and G3 are taken, chick rickets incidence observation hatching of breeding eggs after oral to breeder.Specific implementation
It is as follows：
Scale kind chicken house breeder 200 is taken, is divided into 4 groups, every group 50, first group is group of not taking medicine, and breeder removes feed
Outward, calcium agent is not supplemented additionally；2-4 groups are set to G1, G2 and G3 group, and breeder distinguishes oral supplementation G1, G2 and G3 samples in addition to feed
Product, every 10g is used in conjunction 3 days, takes the fertile egg after feeding three days, and every chicken takes 3, artificial incubation is carried out, 3 after observation hatching
Chick rickets incidence in age in days, as a result such as table four.
Table four：Prevention situation of the calcium tablet to chick rickets
Be can be seen that in the age in days of G1 groups chick 3 without generation osteomalacia, G2 and G3 group chick rickets by data in table four
Sick rate illustrates that inventive samples are good for preventing the osteomalacia in the age in days of chick 3 to have also far below a group chick of not taking medicine
The effect of effect, wherein G1 is better than G2 and G3.
The above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, on the premise of principle of the present invention is not departed from, some improvements and modifications can also be made, these improvements and modifications
Should be regarded as protection scope of the present invention.
Claims (9)
1. a kind of animal specific calcium tablet, it is characterised in that following component is included in animal specific calcium tablet described in per 100g：
2. animal specific calcium tablet according to claim 1, it is characterised in that included in animal specific calcium tablet described in per 100g
Following component：
3. animal specific calcium tablet according to claim 1 and 2, it is characterised in that in animal specific calcium tablet described in per 100g
Comprising following component：
4. animal specific calcium tablet according to claim 1 and 2, it is characterised in that the calcium ion is wrapped by weight percentage
Containing following component：
Ionic organic calcium 50%
Sequestering organic calcium 40%
Inorganic calcium 10%.
5. animal specific calcium tablet according to claim 4, it is characterised in that the ionic organic calcium is gluconic acid
Mix for one or more in calcium, calcium malate, calcium lactate, calcium acetate, calcium citrate, calcium maleate and glucurone calcium
Compound；The chelating type organic calcium is in l threonic acid, asparagus amino-acid calcium, amino acid chelated calcium and trihydroxy-butyric acid calcium
One or more mixture；The inorganic calcium is one or more mixing in calcium propionate, calcium sulfate, calcium chloride and calcium phosphate
Thing.
6. animal specific calcium tablet according to claim 1 and 2, it is characterised in that the magnesium ion is ASPARTIC ACID
One or more mixture in magnesium, magnesium gluconate and magnesium sulfate.
7. animal specific calcium tablet according to claim 1 and 2, it is characterised in that the phosphonium ion is atriphos two
One or more mixing in sodium, disodium hydrogen phosphate, dibastic sodium phosphate, sodium phosphate, potassium dihydrogen phosphate, potassium hydrogen phosphate and potassium phosphate
Thing.
8. animal specific calcium tablet according to claim 1 and 2, it is characterised in that the species of the Feed Flavourings includes using
Feed Flavourings in pig, the Feed Flavourings for cat, the Feed Flavourings for dog and the Feed Flavourings for chicken, wherein, use
Include flavoring apple essence, strawberry essence and milk flavour in the Feed Flavourings of pig；Feed Flavourings for cat include fish flavour essence, ox
Milk essence and beef flavor；Feed Flavourings for dog include milk flavour, beef flavor, chicken essence and coffee aroma；With
Include garlic flavoring in the Feed Flavourings of chicken.
9. the preparation method of a kind of animal specific calcium tablet as any one of claim 1~8, it is characterised in that including
Following steps：
(1) screen：Raw material described in prescription is utilized respectively into the mesh screen that aperture is 0.3~0.5mm to be screened, the lower raw material of sieve is made
It is calcium tablet raw material for standby；
(2) material powder of calcium ions, magnesium ion and phosphonium ion is weighed according to recipe quantity, is placed in three-dimensional mixer, fully
Mix；
(3) CPP, 25- carboxyl vitamin Ds are sequentially added to the mixture of step (2) according to recipe quantity3And microorganism
C, fully mixes；
(4) sucrose, sodium alginate, odium stearate and Feed Flavourings are sequentially added in the mixture according to recipe quantity to step (3),
Fully mix；
(5) starch is added in the mixture according to recipe quantity to step (4), is fully mixed；
(6) mixed powder mixed in step (5) is transferred in tablet press machine, carries out compressing tablet；
(7) calcium tablet that will be pressed, is transferred in sterile packaging bottle, closed preservation, and animal specific calcium tablet is prepared and completed.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710223590.8A CN106913856A (en) | 2017-04-07 | 2017-04-07 | A kind of animal specific calcium tablet and preparation method thereof |
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| CN201710223590.8A CN106913856A (en) | 2017-04-07 | 2017-04-07 | A kind of animal specific calcium tablet and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108740305A (en) * | 2018-05-10 | 2018-11-06 | 青岛农业大学 | Special calcium tablet of Diseases of Cow and preparation method thereof |
| WO2020191426A1 (en) * | 2019-03-22 | 2020-10-01 | Jake Stockfeed Pty Ltd | Horse supplement |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108740305A (en) * | 2018-05-10 | 2018-11-06 | 青岛农业大学 | Special calcium tablet of Diseases of Cow and preparation method thereof |
| CN108740305B (en) * | 2018-05-10 | 2021-09-17 | 青岛农业大学 | Special calcium tablet for perinatal dairy cows and preparation method thereof |
| WO2020191426A1 (en) * | 2019-03-22 | 2020-10-01 | Jake Stockfeed Pty Ltd | Horse supplement |
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