CN103053807A - Water-soluble composite vitamin preparation and preparation method thereof - Google Patents
Water-soluble composite vitamin preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a water-soluble composite vitamin preparation for animals and a preparation method thereof. The preparation comprises a vitamin complex, N,N-dimethyl formamide, tween-80 and glycerol, wherein the vitamin complex comprises the following components in parts by mass: vitamin A, vitamin D3, vitamin E, biotin, vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, nicotinic acid, vitamin C, pantothenic acid, methionine, lysine, disodium ethylene diamine tetraacetic acid (EDTA-2Na) and sodium benzoate. The composite vitamin preparation is stable in properties, and can be diluted by using water in any ratio. By drinking water, vitamins can be complemented to the animals, so the preparation is convenient to use.
Description
Technical field
The present invention relates to a kind of Aquavite preparation and preparation method thereof, be specifically related to the Aquavite preparation that a kind of animal is used, formed by tens kinds of vitamins and a few seed amino acid, but spice uses or directly is watered oral, be applicable to various poultries, laying hen and poultry, and called after " steps " moving.
Background technology
Vitamin is that animal is kept normal physiological function and an essential class trace organic substance plays an important role in growth, metabolism, growth course.Though vitamin is not the constituent that consists of body tissue and cell, can produce power yet, but it mainly is to participate in metabolic adjusting, is the important composition composition of coenzyme in the body enzyme system, animal is very little to the requirement of vitamin, will cause corresponding vitamin-deficiency in case lack.Most vitamin, body can not synthesize or synthetic quantity when not enough, must be by obtaining in the food when needing.
Supporting one's family of finding at present have kind more than 60, can be divided into fat-soluble and water-soluble two large classes, liposoluble vitamin commonly used has A, D, E, K, they are stored in liver in vivo, by discharging in the liver, and water soluble vitamin is distributed in extracellular fluid in vivo, stores seldom in the body when needing, easily from urine, discharge, as replenishing untimely very easily shortage.Water soluble vitamin commonly used has Cobastab, and (Cobastab comprises B
1, B
2, B
6, B
12, biotin, folic acid, nicotinic acid, pantothenic acid, also have the people that choline, inositol, p-aminobenzoic acid, carnitine, lipoic acid are included) and vitamin C etc.
Vitamin A has the growth of promotion, keeps the effect of epithelial tissue normal function, and participates in the synthetic of rhodopsin, strengthens amphiblestroid sensitization power.Lack vitamin A and easily suffer from yctalopia.
Vitamin D has five kinds of compounds, can regulate the metabolism of calcium, phosphorus, promotes the normal growth of bone, to the health relation closer be vitamin D
2And vitamin D
3To the people, find also in the research of mouse and milk cow that immunocyte and myocyte also need vitamin D with the performance best-of-breed functionality.
Vitamin E comprises tocopherols, tocotrienol class.Anti-oxidation function is arranged, by the animal normal growth and the fertility essential.
Vitamin K
1Essential material for synthetic factor in the liver can cause blood coagulation disorders when lacking.
Cobastab
1The activity that can suppress cholinesterase, the increased activity of cholinesterase during shortage, acetylcholine hydrolyzation accelerates, and causes the nerve impulse conductive impairment, affects stomach and intestine, the function of cardiac muscle.
Cobastab
2Play an important role for the normal function of keeping skin, mucous membrane and vision.Lack Cobastab
2Easily suffer from dispute inflammation (canker sore) etc.
Nicotinic acid is called again Cobastab
3, it does not still keep the vitamin of digestive system health, is the synthetic indispensable material of sex hormone yet.Nicotinic acid is converted into niacinamide in human body, niacinamide is the part of cozymase and codehydrogenase Ⅱ, participates in HypercholesterolemicRats, the process that the oxidizing process of tissue respiration and carbohydrate anaerobic are decomposed.
Cobastab
5Claim again pantothenic acid.Anti-stress, cold resistance, anti-infective, prevent some antibiotic toxicity, eliminate postoperative abdominal distention.
Cobastab
6Be combined into phosphopyridoxal pyridoxal phosphate or phosphopyridoxamine with phosphoric acid in vivo.They are coenzyme of the relevant amino acid metabolism enzyme of many kinds, so very important to amino acid metabolism.
Cobastab
12Claiming again cobalamin, contain the metallic element cobalt, is unique metallic element that contains in the vitamin, and AFL promotes the storage of vitamin A in liver, promotes cell development maturation and organism metabolism.
Biotin is the coenzyme of multiple carboxylase, plays CO in the carboxylase reaction
2The effect of carrier, for the heteroplasia of glycogen, the comprehensive function of aliphatic acid and some amino acid whose metabolism all are the controlling elements of a key, and generation that can be by helping energy is to the synthetic facilitation that plays of some protein; But helper cell is grown, is made aliphatic acid, metabolism carbohydrate, fat and protein simultaneously, and helps vitamin B group's utilization; Promote sweat gland, nerve fiber, the health of marrow, male gonad; Safeguard normal operation and the growth of skin and hair, alleviate eczema, dermatitis symptom; Also participate in Cobastab
12, folic acid, pantothenic acid metabolism; Promote the synthetic and drainage of urea; Improve the immunologic function of human body.
Inositol is a kind of water soluble vitamin, can promote cell metabolism, fosters growth, improve a poor appetite, and is used for the treatment of liver liposis, cirrhosis disease.
The effects such as folic acid participation hyperplasia, reproduction, ferroheme synthesize, to the differentiation and maturation of blood cell, fetal development (blood cell hyperplasia and fetal nerve are grown) has great impact.
Vitamin C is again L-AA, can treat scurvy and have acidity, so be called ascorbic acid.It can also strengthen immunity and, also beneficial to skin, gum and nerve.
Methionine is one of essential amino acid that consists of human body, and it is synthetic to participate in protein.Because it can not self generate in vivo, so must be obtained by the outside.If lack and to cause body internal protein biosynthesis block, cause body damage.The membrane lipid over oxidation that oxygen radical causes in the body is the reason that causes the multiple infringement of body.MDA can damage the primary and secondary lysosome membrane, and the acid phosphatase that the conduct that lysosome is contained is hydrolyzed discharges, and the important organelles such as cell and mitochondrial membrane are caused damage, and methionine is resisted these infringements by number of ways.
Lysine is one of essential amino acid, can promote the human development, strengthen immunologic function, and be improved the effect of central nervous tissue function.Lysine is alkaline essential amino acid.
Above composition is applied to aquaculture after compound, can reduces the disease that certain vitamin for want of causes, and can improve the immunity of livestock and poultry, promotion is grown, and hair is bright-coloured etc.
Summary of the invention
The object of the present invention is to provide a kind of Aquavite preparation.
Another object of the present invention is to provide a kind of preparation method of Aquavite preparation.
Purpose of the present invention is achieved through the following technical solutions:
A kind of Aquavite preparation, comprise the vitamin compound, N, dinethylformamide, Tween 80 and glycerine, described vitamin compound comprises following component by mass parts: 15 ~ 25 parts of vitamin As, 3 ~ 5 parts of cholecalciferols, 15 ~ 25 parts of vitamin Es, 0.3 ~ 0.7 part of biotin, 0.6 ~ 1.4 part of prokeyvit, 2 ~ 4 parts of vitamin B1s, 2.5 ~ 4.5 parts of vitamin B2s, 1 ~ 3 part of vitamin B6,0.2 ~ 0.4 part of cobalamin, 4 ~ 6 parts in folic acid, 2.5 ~ 4.5 parts in nicotinic acid, 0.6 ~ 1.4 part of vitamin C, 0.6 ~ 1.4 part in pantothenic acid, 0.6 ~ 1.4 part of methionine, 0.6 ~ 1.4 part of lysine, 0.6 ~ 1.4 part of 0.05 ~ 0.15 part of EDTA-2Na and Sodium Benzoate, described vitamin compound and N, the mass volume ratio g:ml of dinethylformamide is 10 ~ 20:100, the mass volume ratio g:ml of described vitamin compound and Tween 80 is 10 ~ 20:10, and the mass volume ratio g:ml of described vitamin compound and glycerine is 10 ~ 20:10.
Tiring 〉=500,000 IU/g of described vitamin A, the tiring 〉=500,000 IU/g of described cholecalciferol, the tiring 〉=500IU/g of described vitamin E.
The preparation method of above-mentioned Aquavite preparation is:
(1) in proportion DMF, Tween 80, glycerine and purified water are put into container, stir, then put in proportion EDTA-2Na, Sodium Benzoate, lysine, methionine and vitamin C stirring and dissolving;
(2) vitamin A, cholecalciferol, vitamin E are put into described container stirring and dissolving;
(3) vitamin B1, vitamin B2, vitamin B6, cobalamin, prokeyvit, biotin, folic acid, nicotinic acid, pantothenic acid are put into described container stirring and dissolving;
(4) use at last lemon acid for adjusting pH to 4.0, add water and adjust to desired concn.
The addition of water can be adjusted according to required formulation concentrations in the preparation.
Vitamin is relatively more responsive to heavy metal, therefore adds EDTA-2Na in solution heavy metal ion is carried out chelating, prevents heavy metal to the impact of vitamin, and methionine, the lysine in the preparation also can the various trace elements of chelating simultaneously.The pH of this preparation is in the degraded that acidity has been avoided vitamin.Glycerine is coated with fat-soluble vitamin, has increased the stability of vitamin in water, has increased simultaneously the dissolubility in water and has improved absorbing of animal.DMF can keep the relative independence of various vitamins with Tween 80, has reduced the reaction between vitamin mutual impact, particularly vitamin C and the vitamin B complex.This method preparation method is simple, as long as just can prepare with common raw material, and most important be exactly that the speed that decays of vitamin is obviously slack-off.
Beneficial effect of the present invention:
The speed of vitamin decay is obviously slack-off in the Aquavite preparation of the present invention, and the stability of vitamin in water is high, has increased simultaneously the dissolubility of vitamin in water and more has been conducive to improve absorption and the utilization rate of animal.Said preparation is applied to aquaculture, can reduce the disease that certain vitamin for want of causes, and can improve the immunity of livestock and poultry, promotes growth, and hair is bright-coloured etc.
The specific embodiment
Embodiment 1
The content of various compositions in the Aquavite preparation of the every 1L of table 1.
Preparation technology:
(1) will put into the DMF of 500 ml in the container, the purified water of 200ml, the Tween 80 of 50ml, the glycerine of 50ml stirs, and puts into successively EDTA-2Na, Sodium Benzoate, lysine, methionine, vitamin C, is stirred to dissolving.
(2) vitamin A, cholecalciferol, vitamin E are put into the solution stirring and dissolving successively.
(3) vitamin B1, vitamin B2, vitamin B6, cobalamin, prokeyvit, biotin, folic acid, nicotinic acid and pantothenic acid are put into the solution stirring and dissolving successively.
(4) use at last lemon acid for adjusting pH to 4.0, add the purified water constant volume to 1000ml.
(5) sealing of packing in the container is preserved.
Embodiment 2
The content of various compositions in the Aquavite preparation of the every 1L of table 2.
Preparation technology:
(1) will put into the DMF of 300 ml in the container, the purified water of 200ml, the Tween 80 of 30ml, the glycerine of 30ml stirs, and puts into successively EDTA-2Na, Sodium Benzoate, lysine, methionine, vitamin C is stirred to dissolving.
(2) with vitamin A, cholecalciferol, vitamin E are put into the solution stirring and dissolving successively.
(3) with vitamin B1, vitamin B2, vitamin B6, cobalamin, prokeyvit, biotin, folic acid, nicotinic acid, pantothenic acid are put into the solution stirring and dissolving successively.
(4) use at last lemon acid for adjusting pH to 4.0, add the water constant volume to 1000ml.
(5) sealing of packing in the container is preserved.
Embodiment 3
The content of various compositions in the Aquavite preparation of the every 1L of table 3.
Preparation technology:
(1) will put into the DMF of 600 ml in the container, the purified water of 200ml, the Tween 80 of 60ml, the glycerine of 60ml stirs, and puts into successively EDTA-2Na, Sodium Benzoate, lysine, methionine, vitamin C is stirred to dissolving.
(2) with vitamin A, cholecalciferol, vitamin E are put into the solution stirring and dissolving successively.
(3) with vitamin B1, vitamin B2, vitamin B6, cobalamin, prokeyvit, biotin, folic acid, nicotinic acid, pantothenic acid are put into the solution stirring and dissolving successively.
(4) use at last lemon acid for adjusting pH to 4.0, add the water constant volume to 1000ml.
(5) sealing of packing in the container is preserved.
Test one
1 material method
1.1 test specimen
The Aquavite compound formulation is by example 1 preparation.Various vitamin standard items are bought from Nat'l Pharmaceutical ﹠ Biological Products Control Institute.
1.2 key instrument and reagent
High performance liquid chromatograph LC-20AT(Japan Shimadzu); Constant temperature humidity chamber on the table (Dongguan City Jie Te Instr Ltd.); The used reagent of liquid phase is chromatographically pure, and all the other reagent are pure for analyzing.
1.3 method
The Aquavite compound formulation sample of embodiment 1 preparation under 37.5 ℃ of temperature and relative humidity 75% condition, was deposited 3 months, detected per month totally 4 times 1 time.Detect the content high performance liquid chromatography of various vitamins in the preparation.
The vitamin A. D. E assay is pressed GB/T17817-2010, GB/T17818-2010, the prescriptive procedure of GB/T17812-2008.Vitamin B1, B2, B6, B12, C, K assay are pressed, GB/T14700-2002, GB/T14701-2002, GB/14702-2002, GB/T17819-1999, GB/T 7303-2006 and GB/TGB/T18872-2002, the method for regulation.Pantothenic acid, nicotinic acid, folate content are measured the method for pressing GB/T7299-2006 GB/T7300-2006 and GB/T7302-2008 regulation.
2. result
The retention rate (measure content/input content) of various vitamins in the Aquavite compound formulation sample of embodiment 1 preparation in 3 months all more than 90%, can find out that various vitamins can keep relative stability in the preparation of the present invention as can be seen from Table 4.
3 months retention rate results (%) of various vitamins in the Aquavite compound formulation sample of table 4. embodiment 1 preparation
Test two
1 material method
1.1 test material
Test period is in May, 2012.Select 300 ages in days totally 96 sea blue grey commodity eggs of health.The blank group is set, medicine control group, 3 processing of drug test group; Each processes 30 chickens.The blank group basal diet of throwing something and feeding, the medicine control group is drunk the water that has added buddhist promise liquid multi-dimensional on the basis of basal diet, per 1 ton of water adds the buddhist promise multidimensional of 250ml, and (Foshan City abdicates at the South Sea safe animal pharmaceutical estate Co., Ltd, lot number 110901), freely drink.The drug study group is drunk the animal of having added embodiment 1 preparation with the water of water-soluble Cernevit-12 on the basis of basal diet, per 1 ton of water adds the water-soluble Cernevit-12 of animal that the embodiment 1 of 250ml prepares.
1.2 basal diet prescription
The composition of basal diet is seen following table 5.All test chickens are with same batch basal diet.
The composition of table 5. basal diet
1.3 feeding and management
Test chicken adopts three layers of trapezoidal raising in cages, 4 in every cage, free choice feeding and drinking-water.Preliminary trial periods 7 d, statistics was respectively organized feed intake, laying rate, egg size when preliminary trial period finished, through data statistics during without significant difference (P＞0.05) begin test, experimental periods 21 d.
1.4 the mensuration of production target
Egg production, the egg size of record the 7th, 14,21 d are tied weekly 1 defective material after the prerun off-test, and the record feed consumption rate calculates laying rate [100 * (total quantity of every group of egg/every group of chicken quantity)/total fate], average egg weight, average feed intake.
2. result and discussion
The water soluble vitamin compound formulation of embodiment 1 preparation and existing vitamin preparation are on the impact (seeing Table 6) of Egg Production of Laying Hens
Add the vitamin compound formulation in table 6. daily ration to the impact of Layer Production Performance
No matter the chicken of the blank group of the chicken of drug test group and medicine control group ratio is in laying rate or on average egg weight as can be seen from Table 6, effect has obvious lifting.On laying rate, drug test group, medicine control group have increased respectively 41.2%, 19.6% with respect to the blank group, and wherein the drug test group has increased by 18% than medicine control group.
Therefore the animal of the present invention's preparation has significantly effect with water-soluble Cernevit-12 for improving laying rate of laying hen, because contain the demand that multivitamin is conducive to laying hen nutrition in this Cernevit-12.Buddhist promise and Cernevit-12 of the present invention are similar in trophic component, but wherein the stability of vitamin is not as Cernevit-12 of the present invention, and effect is not as Cernevit-12 of the present invention under the similarity condition.
Claims (4)
1. Aquavite preparation, it is characterized in that comprising the vitamin compound, N, dinethylformamide, Tween 80 and glycerine, described vitamin compound comprises following component by mass parts: 15 ~ 25 parts of vitamin As, 3 ~ 5 parts of cholecalciferols, 15 ~ 25 parts of vitamin Es, 0.3 ~ 0.7 part of biotin, 0.6 ~ 1.4 part of prokeyvit, 2 ~ 4 parts of vitamin B1s, 2.5 ~ 4.5 parts of vitamin B2s, 1 ~ 3 part of vitamin B6,0.2 ~ 0.4 part of cobalamin, 4 ~ 6 parts in folic acid, 2.5 ~ 4.5 parts in nicotinic acid, 0.6 ~ 1.4 part of vitamin C, 0.6 ~ 1.4 part in pantothenic acid, 0.6 ~ 1.4 part of methionine, 0.6 ~ 1.4 part of lysine, 0.6 ~ 1.4 part of 0.05 ~ 0.15 part of EDTA-2Na and Sodium Benzoate, described vitamin compound and N, the mass volume ratio g:ml of dinethylformamide is 10 ~ 20:100, the mass volume ratio g:ml of described vitamin compound and Tween 80 is 10 ~ 20:10, and the mass volume ratio g:ml of described vitamin compound and glycerine is 10 ~ 20:10.
2. Aquavite preparation according to claim 1 is characterized in that tiring 〉=500,000 IU/g of described vitamin A, the tiring 〉=500,000 IU/g of described cholecalciferol, the tiring 〉=500IU/g of described vitamin E.
3. Aquavite preparation according to claim 1 is characterized in that adopting the following methods preparation:
(1) in proportion DMF, Tween 80, glycerine and purified water are put into container, stir, then put in proportion EDTA-2Na, Sodium Benzoate, lysine, methionine and vitamin C stirring and dissolving;
(2) vitamin A, cholecalciferol, vitamin E are put into described container stirring and dissolving;
(3) vitamin B1, vitamin B2, vitamin B6, cobalamin, prokeyvit, biotin, folic acid, nicotinic acid, pantothenic acid are put into described container stirring and dissolving;
(4) use at last lemon acid for adjusting pH to 4.0, add water and adjust to desired concn.
4. the preparation method of Aquavite preparation claimed in claim 1 is characterized in that may further comprise the steps:
(1) in proportion DMF, Tween 80, glycerine and purified water are put into container, stir, then put in proportion EDTA-2Na, Sodium Benzoate, lysine, methionine and vitamin C stirring and dissolving;
(2) vitamin A, cholecalciferol, vitamin E are put into described container stirring and dissolving;
(3) vitamin B1, vitamin B2, vitamin B6, cobalamin, prokeyvit, biotin, folic acid, nicotinic acid, pantothenic acid are put into described container stirring and dissolving;
(4) use at last lemon acid for adjusting pH to 4.0, add water and adjust to desired concn.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105813480A (en) * | 2013-12-11 | 2016-07-27 | 帝斯曼知识产权资产管理有限公司 | A nutritional reinforced composition and a process for preparation thereof |
| CN112336731A (en) * | 2020-11-02 | 2021-02-09 | 北京诺康达医药科技股份有限公司 | Vitamin oral liquid and preparation method and application thereof |
| CN114099516A (en) * | 2020-09-01 | 2022-03-01 | 河北科星药业有限公司 | Compound amino acid solution for animals and preparation method and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559263A (en) * | 2004-03-05 | 2005-01-05 | 天津农学院 | Composite and premixed forage for shrimps |
| CN1823809A (en) * | 2005-12-31 | 2006-08-30 | 无锡凯夫制药有限公司 | Preservative less water soluble vitamin preparation for injection and its formulating method |
| CN101461821A (en) * | 2008-07-04 | 2009-06-24 | 青岛康地恩药业有限公司 | Compound oral medicament composition for treating respiratory diseases of pig and cattle |
| CN101971916A (en) * | 2010-08-14 | 2011-02-16 | 格特生物制药（天津）有限公司 | Liquid compound premixed feed containing mineral substances and amino acid |
| CN101971919A (en) * | 2010-08-14 | 2011-02-16 | 格特生物制药（天津）有限公司 | Liquid premixed feed of composite mineral substance |
| CN101978851A (en) * | 2010-08-17 | 2011-02-23 | 格特生物制药（天津）有限公司 | Three-in-one multifunctional premixed liquid feed and preparation method thereof |
| CN102626187A (en) * | 2012-04-09 | 2012-08-08 | 上海农好饲料有限公司 | Compound feed for egg-laying duck and preparation method thereof |
-
2013
- 2013-01-24 CN CN201310027681.6A patent/CN103053807B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559263A (en) * | 2004-03-05 | 2005-01-05 | 天津农学院 | Composite and premixed forage for shrimps |
| CN1823809A (en) * | 2005-12-31 | 2006-08-30 | 无锡凯夫制药有限公司 | Preservative less water soluble vitamin preparation for injection and its formulating method |
| CN101461821A (en) * | 2008-07-04 | 2009-06-24 | 青岛康地恩药业有限公司 | Compound oral medicament composition for treating respiratory diseases of pig and cattle |
| CN101971916A (en) * | 2010-08-14 | 2011-02-16 | 格特生物制药（天津）有限公司 | Liquid compound premixed feed containing mineral substances and amino acid |
| CN101971919A (en) * | 2010-08-14 | 2011-02-16 | 格特生物制药（天津）有限公司 | Liquid premixed feed of composite mineral substance |
| CN101978851A (en) * | 2010-08-17 | 2011-02-23 | 格特生物制药（天津）有限公司 | Three-in-one multifunctional premixed liquid feed and preparation method thereof |
| CN102626187A (en) * | 2012-04-09 | 2012-08-08 | 上海农好饲料有限公司 | Compound feed for egg-laying duck and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 吴博睿等: "复合维生素预混料生产的质量控制", 《山东畜牧兽医》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105813480A (en) * | 2013-12-11 | 2016-07-27 | 帝斯曼知识产权资产管理有限公司 | A nutritional reinforced composition and a process for preparation thereof |
| CN114099516A (en) * | 2020-09-01 | 2022-03-01 | 河北科星药业有限公司 | Compound amino acid solution for animals and preparation method and application thereof |
| WO2022047840A1 (en) * | 2020-09-01 | 2022-03-10 | 河北科星药业有限公司 | Compound amino acid solution for animal, preparation method therefor, and application thereof |
| CN112336731A (en) * | 2020-11-02 | 2021-02-09 | 北京诺康达医药科技股份有限公司 | Vitamin oral liquid and preparation method and application thereof |
| CN112336731B (en) * | 2020-11-02 | 2021-12-14 | 北京诺康达医药科技股份有限公司 | Vitamin oral liquid and preparation method and application thereof |
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