JP4818177B2 - Bone and muscle enhancement promoting composition for elderly - Google Patents

Description

  The present invention relates to a novel composition for promoting bone and muscle enhancement for the elderly.

  The population of people over the age of 50 in Japan has been increasing year by year and is expected to exceed 30 million by 2025. In such a situation, measures for maintaining and improving the health of the elderly have become increasingly important in recent years. The reason that each elderly person becomes more energetic is because not only can they have a more fulfilling life after retirement, but it will also lead to a reduction in medical expenses socially.

  One of the reasons why elderly people become bedridden is “fractures caused by falls”. As you get older, muscle mass decreases and bone density decreases, making it easier to fall over, and very easy to break when you fall. It is also said that women have more than twice the ease of fracture because men lose their bones due to the decrease in female hormones due to menopause.

  In order to prevent a fracture due to a fall, it is first necessary to “do not fall”, and it is important to prevent a decrease in muscle strength and maintain and increase muscle mass. In order to maintain and increase muscle mass, it is best to continue moderate muscle training continuously, but for elderly people, heavy workload training is not appropriate, so more efficient muscle training with less load Is required to do.

Therefore, the present inventors conducted research aimed at developing a food composition that can more effectively maintain and increase muscle mass and increase bone density, together with training for preventing falls and fractures. . The present inventors have applied for a patent for a food composition containing creatine, glucosamine, or glycosaminoglycan as an active ingredient as a food composition for improving joint pain (Japanese Patent Application No. 2005-284865). However, the effects of this composition are those that relieve joint pain, and are not focused on muscle mass or bone density.
However, since creatine is said to be effective in strengthening muscles in the first place, and glycosaminoglycan is said to be effective in cartilage formation, it is based on this food composition. The study was conducted with a focus on vitamin D, which is expected to be effective in treatment, and hyaluronic acid, which is expected to be effective in cartilage formation.

  Regarding bone formation technology, Patent Document 1 discloses foods and beverages combining isoflavones and peptides as foods for preventing falls and fractures. Patent Document 2 discloses that a composition containing hyaluronic acid and vitamin D is used as a filler for a gap portion of a bone defect as a bone filling composition, a bone filling medical device, and a bone filling kit. Patent Document 3 discloses a creatine compound therapeutic composition for bone or chondrocytes.

According to the above patent publication, creatine, vitamin D, and hyaluronic acid have been known to be effective in increasing bone and muscle mass, but there is no example of combining them as food and drink, for preventing falls and fractures. No food composition using creatine, vitamin D, or glycosaminoglycan as a food has been known.
Patent Publication 2000-139411 Patent Publication 2002-58736 Patent Publication 2002-521440

  In view of the above situation, the present inventors considered that the combination of creatine, vitamin D, and hyaluronic acid has an effect of increasing bone and muscle mass, and thus is very effective as a food for falling and preventing, and as a result of earnest research, The present invention has been completed.

  It is an object of the present invention to provide a composition for promoting bone / muscle enhancement that is useful for preventing falls and fractures of the elderly, and the present invention can also be taken together in low-exercise exercise or daily life. It is an object of the present invention to provide a food composition whose effect is remarkably increased.

  Among the present inventions for solving the above-mentioned problems, the invention described in claims 1 and 2 is a bone / muscle augmentation comprising creatine, vitamin D, glucosamines and glycosaminoglycans as active ingredients. It is a food composition for promotion.

  The invention described in claim 2 is adjusted so that the daily intake is 0.3 to 5 g of creatine, 1 μg to 50 μg of vitamin D, 0.1 to 2 g of glucosamine, and 0.1 to 2 g of glycosaminoglycan. The food composition according to claim 1.

  The invention described in claim 3 is the food composition according to any one of claims 1 to 3, wherein the glucosamine is glucosamine, a derivative thereof, or a salt thereof.

  The invention described in claim 4 is the food composition according to claim 1 or 2, characterized by containing hyaluronic acid.

  The invention described in claim 5 is the food composition according to any one of claims 1 to 4, wherein the glycosaminoglycans are chondroitin sulfate or a salt thereof or a decomposition product thereof.

  The invention described in claim 6 is the food composition according to any one of claims 1 to 5, wherein the vitamin D is derived from a plant or an animal.

  The invention described in claim 7 is the food composition according to any one of claims 1 to 6, wherein the creatine is creatine or a compound thereof.

The invention described in claim 8 further includes calcium, collagen, green shellfish, MSM (methylsulfonylmethane), S-adenosylmethionine, cat's claw, hyaluronic acid, α lipoic acid, ornithine, carnitine, coenzyme Q10, citrulline. A food composition according to any one of claims 1 to 7, wherein at least one selected from quercetin is added.

  According to the present invention, it is possible to provide a composition for promoting bone / muscle enhancement that is effective in preventing falls and fractures of the elderly.

  Hereinafter, the present invention will be described in detail.

The composition for promoting bone / muscle enhancement according to the present invention is based on creatine, vitamin D, glucosamine, and glycosaminoglycan as active ingredients.
In the present invention, each ingredient is blended so that the daily intake is 0.3 to 5 g of creatine, 1 μg to 50 μg of vitamin D, 0.1 to 2 g of glucosamine, and 0.1 to 2 g of glycosaminoglycan, It is added to food.

  In the present invention, creatine refers to creatine or a compound thereof. As creatine, creatine monohydrate is preferably used. In addition, creatine compounds such as homocreatine, cyclocreatine, homocyclocreatine, creatine phosphate, creatine pyruvate, and creatine citrate may be used.

  Creatine is made in the human body, and its total savings are about 140 g for an average adult male (70 kg body weight). Of these, the daily creatine metabolism is estimated to be 2-3 g (about 1.6% of total savings). Creatine is synthesized from amino acids in the body, but the amount of synthesis is half the daily requirement, and the rest must be taken from the diet. Creatine is a little contained in dairy products (0.1 g / kg for milk) but abundant in livestock and fish (5 g / kg for beef and pork, 10 g / kg for herring, respectively) kg). Creatine taken with meals is absorbed as it is from the intestinal tract and enters the blood. The creatine in the blood is transported to body tissues such as the heart, brain, and testis, and most of it is stored in skeletal muscle.

  In the present invention, the glucosamine is glucosamine or a derivative thereof. Glucosamines are a type of amino acid that is made from glucose in the body, and are distributed in connective tissues such as cartilage, tendons, ligaments and the like as proteoglycans as components of glycoproteins in animals. Glucosamine is a basic nutritional component for forming chondrocytes, and plays an important role in the metabolism of cells in joints. Glucosamine is also used to treat osteoarthritis. The term “glucosamine” as used herein refers to a saccharide having a hydroxyl group substituted with an amino group. It is naturally contained in animal, plant, and microbial polysaccharides, mucopolysaccharides, glycoproteins, glycolipids, bacterial cell wall peptidoglycans, and lipopolysaccharides, and the chemical system name is said to be 2-amino-2-deoxyglucose. Glucosamine is industrially obtained, for example, by hydrolyzing chitin as a raw material. In the present invention, derivatives such as glucosamine hydrochloride, glucosamine sulfate, N-acetylglucosamine are also included. Glucosamine or a derivative thereof is preferably a natural product, but can also be used as a synthetic product. The blending amount of glucosamines can be selected from a wide range of about 0.5 to 90% by weight with respect to the whole composition. For example, the blending amount of glucosamines is 1 to 90% by weight, preferably 5 to 80% by weight, More preferably, it is 10 to 50% by weight.

  The glycosaminoglycans (mucopolysaccharides or acidic mucopolysaccharides) referred to in the present invention are a series of acidic polysaccharides containing glucosamine, and include, for example, hyaluronic acid, chondroitin or salts thereof. Preferred glycosaminoglucans include chondroitin or chondroitin sulfate or salts thereof and their degradation products. Chondroitin or a salt thereof can be obtained from natural products such as animal cartilage or collagen, and commercially available products can also be used. Salts that can be used not only as purified chondroitin but also as chondroitin or an animal cartilage powder extract / extract containing salts thereof may be physiologically acceptable salts such as hydrochloride and sulfate. Purified chondroitin or chondroitin sulfate or a salt thereof is preferable from the viewpoint of safety, but its decomposition product is still more preferable from the viewpoint of absorbability. The blending amount of glycosaminoglucans such as chondroitin sulfate can be selected from a wide range of about 0.5 to 90% by weight with respect to the whole composition. For example, the blending amount of glycosaminoglucans is 1 to 90% by weight. %, Preferably 5 to 80% by weight, more preferably 10 to 60% by weight.

  In the present invention, the vitamin Ds can be selected from animal and vegetable ones. The amount of vitamin D can be selected as appropriate for the entire composition, but excessive intake of vitamin D may lead to hyperplasia such as hypercalcemia, so the daily intake is 1 μg to 50 μg. It is necessary to mix | blend so that it may become.

  In the present invention, the hyaluronic acid is hyaluronic acid or a salt thereof. As hyaluronic acid, hyaluronic acid obtained from umbilical cord, vitreous body, chicken crown, microorganisms and the like can be used. A compounding quantity can be selected from the wide range of about 0.5 to 90 weight% with respect to the whole composition, Preferably it is 5 to 80 weight%, More preferably, it is 10 to 60 weight%.

  In the present invention, in addition to creatine, vitamin D, glucosamine, and glycosaminoglycan, calcium, collagen, green clam, MSM (methylsulfonylmethane), S-adenosylmethionine, cat's claw, α lipo Addition of one or more selected from acid, ornithine, carnitine, coenzyme Q10, citrulline, and quercetin further increases the bone and muscle strengthening effect.

  The food composition for bone / muscle augmentation according to the present invention includes excipients, emulsifiers, thickeners, colorings used in the production of ordinary food compositions in addition to the above active ingredients effective for bone / muscle augmentation. A fragrance, a fragrance, a seasoning, a spice, and the like may be appropriately blended.

  As a preferable form of the food composition for bone / muscle augmentation according to the present invention, foods shaped into tablets, granules, and capsules can be mentioned. In addition to health supplements, for example, liquid beverages, powdered beverages, seasonings, processed vegetable foods, processed fruit foods, processed fish foods, meat products, dairy products, processed egg products, spices, breads, confectionery Forms, cooked foods, semi-cooked foods, chilled foods, and the like.

The food composition for bone / muscle augmentation of the present invention is preferably taken every day continuously for 1 month or more, preferably 3 months or more.
Hereinafter, the present invention will be described in more detail with reference to test examples and examples.

Example of tablet food production

Creatine, vitamin D powder, glucosamine, and chondroitin sulfate are mixed in the proportions shown in Table 1, and dextrin, crystalline cellulose, and calcium stearate as a lubricant are mixed in this mixture. The product 1 of the present invention was made. Control product 1 and control product 2 were prepared by the same method and blending.
In addition, “CREAPURE” manufactured by DEGUSSA was used as creatine, and “milk calcium” from Unitech Foods was used as calcium. Other raw materials were purchased and used.

Bone and muscle enhancement effect confirmation test <Test method>
Inventive products 1, 2, 3 and control products 1, 2, 3 manufactured in Example 1 were divided into 10 volunteers each of 60 volunteers (all women over 50 years old) who were worried about falling. Confirmed: 10 tablets per day were continuously ingested daily for one year. In particular, dietary restrictions and exercise programs were not enforced.
(1) Bone density increasing effect confirmation test Each bone density was measured before ingestion and one year after ingestion. The MD method was used as the inspection method. The result is shown in FIG.
FIG. 1 shows changes in the average bone density of each group after ingestion, assuming that the average bone density before ingestion of each group is 100.
(2) Muscle mass increase effect confirmation test Each person's muscle mass was measured before ingestion, 3 months after ingestion, and 1 year after ingestion. The result is shown in FIG. Similarly, the results of measuring knee extension muscle strength are shown in FIG. FIG. 2 shows changes in the average muscle mass of each group when the average before intake of each group is 100, and FIG. 3 shows the average knee extension muscle strength of each group before and after intake.
(3) Fall prevention effect confirmation test In each group, the number of falls in one year before ingestion and the number of falls in one year of intake period were compared. The result is shown in FIG.
(4) Change in QOL of subjects Before and after the intake period in each group, questions related to QOL (Quality of Life) were asked based on the Osteoporosis QOL Evaluation Questionnaire (JOQOL), and responses were obtained. . JOQOL is composed of pain, daily life (ADL), entertainment / social activities, overall health, posture / body type, falls / psychological elements, and has 39 questions. Is also reflected. The total result obtained by adding the points of each question is shown in FIG. The higher the score, the higher the person's QOL.
From the above results, it is clear that the food composition for bone / muscle enhancement according to the present invention has a large effect of increasing bone density and muscle mass, and as a result, an effect of preventing falls. In addition, as shown in FIG. 5, by taking the product of the present invention, it has been confirmed that the quality of life has been improved, such as the number of times pain is felt, the fear of falling, the number of going out increased, etc. It was done. Therefore, it is considered that taking the product of the present invention to prevent falls is a very effective means.

Example of cookie production After mixing 100g of sugar and 100g of margarine well, add 60g of egg, and further 200g of flour, 1g of baking powder, 20g of creatine, 10g of glucosamine, 5g of hyaluronic acid, 0.04g of vitamin D (containing 0.5%), green Cookie dough was prepared by adding 5 g of mussels and 15 g of collagen and kneading lightly. After resting the cookie dough for 1 hour at 10 ° C, the cookie dough was stretched, cut into 9g pieces, and baked in an oven at 190 ° C for 15 minutes to complete. This cookie had a crunchy texture and had a good flavor.

Production example of powder soup As composition, corn powder 30%, skim milk 20%, starch 14%, onion powder 8.39%, creatine 10%, glucosamine 5%, chondroitin sulfate 3%, vitamin D (containing 0.5%) 0.01 %, Α-lipoic acid 5%, flavor enhancer 0.3%, emulsifier 0.3%, salt 3%, powder bouillon 1%, and then processed into granules using a granulator. This was filled in aluminum three-way sticks by 20g and finished. When 1 bag of the powder soup produced in this way was dissolved in 200 g of hot water, it had moderate salty and umami tastes.

  As explained in detail above, the food composition according to the present invention can improve bone density and muscle mass, bring about a fall-preventing effect, and contribute to improving QOL of the elderly, so its social value is large.

The graph which shows the change of the bone density average of each group after ingestion when the bone density average before ingestion of each group is 100 The graph which shows the change of the average muscle mass of each group when the average before intake of each group is set to 100 Comparison of average knee extension muscle strength of each group before and after ingestion Graph showing the number of falls before and after each group intake Graph showing changes in QOL before and after the intake period

Claims (8)

  A food composition for strengthening bones and muscles containing creatine, vitamin D, glucosamines and glycosaminoglycans as active ingredients.   The food composition according to claim 1, wherein the daily intake is adjusted to 0.3 to 5 g of creatine, 1 to 50 μg of vitamin D, 0.1 to 2 g of glucosamine, and 0.1 to 2 g of glycosaminoglycan. .   The food composition according to claim 1 or 2, wherein the glucosamine is glucosamine or a derivative thereof or a salt thereof.   The food composition according to any one of claims 1 to 3, wherein the glycosaminoglycans are hyaluronic acid or a salt thereof.   The food composition according to any one of claims 1 to 4, wherein the glycosaminoglycan is chondroitin sulfate or a salt thereof or a decomposition product thereof.   The food composition according to any one of claims 1 to 5, wherein the vitamin D is derived from a plant or an animal.   The food composition according to any one of claims 1 to 6, wherein the creatine is creatine or a compound thereof. In addition, one or more selected from calcium, collagen, green mussel, MSM (methylsulfonylmethane), S-adenosylmethionine, cat's claw, alpha lipoic acid, ornithine, carnitine, coenzyme Q10, citrulline, quercetin The food composition according to any one of claims 1 to 7.