CN111000230A - Composition for promoting bone health and application - Google Patents

Composition for promoting bone health and application Download PDF

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Publication number
CN111000230A
CN111000230A CN201911166147.7A CN201911166147A CN111000230A CN 111000230 A CN111000230 A CN 111000230A CN 201911166147 A CN201911166147 A CN 201911166147A CN 111000230 A CN111000230 A CN 111000230A
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calcium
composition
bone health
promoting
parts
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韩晓玲
巨建博
吴超
李列琴
田元
权俐
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Xi'an Libang Pharmaceutical Co ltd
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Xi'an Libang Pharmaceutical Co ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The composition for promoting bone health comprises the following raw material components in parts by mass: 3-15 parts of cucumber seeds, 3-15 parts of egg shells, 1-6 parts of human placenta, 1-4 parts of almond oil with long handle, 0.5-3 parts of eucommia seed oil, 0.3-1 part of hydrolyzed egg yolk powder and 0.1-1 part of calcium nutrition enhancer. The composition for promoting bone health, which is prepared by the invention, has the effects of obviously enhancing the physique of children and middle-aged and elderly people and changing the sub-health state of the children and the elderly people; and the composition also has a remarkable improvement effect on bone health diseases, even can be compared with related conventional treatment medicaments to a certain extent, and is expected to be developed into a hot-market product for improving the bone health diseases.

Description

Composition for promoting bone health and application
Technical Field
The invention belongs to the technical field of food, health food and medicine, and particularly relates to a composition for promoting bone health and application thereof.
Background
With the rapid development of social economy, the living standard and medical technology of people are continuously improved, the service life of human beings is prolonged, and the scene brings happiness to people and has certain hidden danger. The aging of the population is intensified, more and more health problems appear, and great troubles are brought to the happy life of human beings. Bone health diseases are one of the typical hidden troubles. According to the statistics of the WHO 1998 survey, the number of people with different degrees of bone health diseases in the world is 3.5 hundred million, and is expected to exceed 8 hundred million (8 hundred million) in 2025. In China, by taking osteoarthritis (called immortal cancer) as an example, which is a common disease in bone health diseases, the sick population reaches about 1.5 hundred million, no regional difference exists, and more young groups exist, so that the disease not only seriously harms the physical health of patients, but also causes endless complications and drug side effects, and is more psychologically feared. Therefore, attention to and prevention of bone health diseases is not slow in China or the world.
The common bone health diseases are diverse, and the pathogenesis and treatment mode are different. Modern medicine has many researches and theories about bone health diseases, and it is thought that factors causing bone health diseases are various, such as mechanical compression, inflammation caused by in vivo biochemical stimulation, immunological problems, metabolic disorders, genetic and nutritional factors, and the like, and the directions are various and the contents are complicated. And as the pathogenesis is still not clear, the treatment is mainly performed by anti-inflammatory, analgesic and hormone drugs, so that various drug side effects are inevitably generated, the physical health of the patient is greatly damaged, and the patient finally has more and more cases of selecting artificial replacement surgery without help.
The traditional Chinese medicine mainly divides the bone health diseases into two types of bone atrophy and bone rheumatism according to the pathogenesis of the bone health diseases. The book of the shou shi baoyuan (longevity life): flaccidity patients also refer to the condition of not moving hands and feet, also known as a soft wind. The internal cause of flaccidity syndrome is related to deficiency-heat, and is described in the "internal Jing" (the internal classic): the lung-heat in the leaf-jiao will cause atrophy; deficiency of heart-qi may cause flaccidity of pulse; atrophy of tendons due to liver-qi heat; spleen-qi heat, marked by atrophy of meat; kidney-qi is hot and the failure of bones occurs. The root of the disease is known, and the book Su Wen & Yin Yang ought to be discussed in the treatise on the theory of generation of bone marrow by the kidney. Therefore, atrophy of bones is closely related to kidneys, and the treatment of atrophy of bones should be mainly based on tonifying kidneys. Bone bi-syndrome is another kind of cognition for bone health diseases in traditional Chinese medicine, and is described in the Chinese Tibetan Jing: the blockage of arthralgia is also called arthralgia because the internal organs of the body are affected by pathogenic qi, disturbing the true qi and blocking without moving. It can be seen that the definition of arthralgia syndrome starts with the etiology and is caused by the disorder of qi activity and disharmony of blood vessels due to the external factors of the five zang-organs and six fu-organs. Therefore, the treatment of bone impediment should be mainly based on activating blood and resolving stasis. As can be seen from the above, the traditional Chinese medicine has more thorough research on the pathogenesis of the bone health diseases and has better feasibility in the aspects of preventing and eradicating the bone health diseases.
Intensive research into patent documents related to the prevention and treatment of bone health diseases has been conducted, and patent CN201480018027 relates to a bone growth stimulating composition comprising components such as polyphenol, vitamin D, bioactive molecules, calcium (or magnesium), and the like, and having an effect of treating, alleviating and preventing cartilage disorders. Patent CN 201611174946 relates to a food composition for bone health comprising rooster comb extract, non-denatured type II collagen, vitamin K2And micro-activating curcumin, and has effects of increasing joint synovial fluid, resisting inflammation, and preventing osteoporosis. Patent CN201711127599 relates to a functional composition for improving bone health, which contains natto powder, hydrolyzed egg yolk powder, milk calcium and other ingredients, can remarkably improve bone joint health, and can be added into food without affecting the taste and flavor of the product. Patent CN 201810125823 relates to a composition for preventing osteoporosis and promoting bone health, which comprises II type collagen peptide, seaweed meal, calcium source, casein phosphopeptide and other components, has high absorption rate and strong pertinence, can promote the absorption and utilization of middle-aged and elderly people with weak digestion and absorption functions, and accelerates the repair of degenerated bones. The analysis of the above patents shows that the bone health patents have common defects, namely the patents achieve the purpose of preventing and treating the bone health diseases by calcium supplement, calcium absorption promotion, bone density increase, bone formation stimulation, inflammation resistance and the like, neglect the disease resistance and regulation functions of the human body, play corresponding roles, but cannot ensure the continuous effect, and treat the symptoms and the root causes. In addition, the patients with bone health diseases are mainly the elderly, and the ability of the patients to absorb calcium and grow bones is greatly hindered due to aging, body degeneration and the like, and the effect is very small.
Disclosure of Invention
In order to overcome the defects of the existing calcium supplement products, the invention provides a composition for promoting bone health, which can prevent and improve bone health diseases by regulating the functions of the body; and has effects in supplementing calcium, promoting calcium absorption, relieving inflammation and pain, promoting osteoblast proliferation, effectively promoting calcification/bone formation, promoting tibial growth, improving bone density, inhibiting osteoclast bone absorption, and reducing osteoclast damage.
Meanwhile, the invention also provides application of the composition for promoting bone health as an effective component in food, health food or medicine for promoting bone health.
The technical scheme adopted by the invention is as follows:
the composition for promoting bone health comprises the following raw material components in parts by mass:
3-15 parts of cucumber seeds, 3-15 parts of egg shells, 1-6 parts of human placenta, 1-4 parts of almond oil with long handle, 0.5-3 parts of eucommia seed oil, 0.3-1 part of hydrolyzed egg yolk powder and 0.1-1 part of calcium nutrition enhancer.
The raw material components further comprise any one or any combination of 0.000005-0.000015 parts of vitamin D, 0.04-0.2 parts of vitamin C, 1-3 parts of β -hydroxy- β -calcium methylbutyrate, 0.3-0.7 part of glucosamine sulfate, 0.07-0.13 part of chondroitin sulfate, 0.08-0.2 part of hyaluronic acid, 0.00003-15 parts of auxiliary bone-strengthening component, 1-15 parts of qi-tonifying and blood-nourishing component, 1-20 parts of nourishing kidney component and 2-20 parts of blood-activating and stasis-removing component.
Further limiting, the calcium nutrition enhancer is any one or more of milk mineral salt, calcium gluconate, calcium lactate, L-calcium lactate, calcium citrate, calcium acetate, calcium L-threonate, calcium glycinate, calcium aspartate, calcium citrate malate, vitamin E calcium succinate, calcium carbonate, calcium sulfate, calcium chloride, calcium oxide, calcium phosphate, calcium hydrogen phosphate, calcium glycerophosphate, and superfine bone meal;
the superfine bone powder is derived from one or more of Os Draconis powder, chicken bone powder or pig bone powder.
Further defined, the vitamin D is specifically one or a combination of ergocalciferol or cholecalciferol.
Further limiting, the vitamin C is specifically any one or more of L-ascorbic acid, L-calcium ascorbate, L-sodium ascorbate, L-potassium ascorbate, magnesium ascorbyl phosphate and ascorbyl palmitate.
Further, the glucosamine sulfate is specifically one or a combination of glucosamine sulfate potassium salt and glucosamine sulfate sodium salt.
Further limiting, the auxiliary bone-strengthening component is any one or more of saccharides, proteins, fats, other vitamins and mineral elements;
the saccharide is any one or more of glucose, fructose, maltose, lactose, sucrose, starch, cellulose, pectin, resistant dextrin, xylooligosaccharide, fructooligosaccharide, isomaltooligosaccharide, isomaltulose, raffinose oligosaccharide, polydextrose, stachyose, chitosan oligosaccharide and trehalose;
the protein is one or more of colostrum basic protein, lactoferrin, non-denatured type II collagen, cartilage collagen, fish collagen, bovine collagen peptide, elastin peptide, oyster peptide and casein phosphopeptide;
the fat is one or more of peanut oil, corn oil, soybean oil, sunflower seed oil, palm oil, coconut oil, lecithin and milk fat;
the vitamins include vitamin A and vitamin B6Vitamin B12Folic acid, vitamin K2Any one or more of them;
the mineral elements are one or more of phosphorus nutrition enhancer, magnesium nutrition enhancer, zinc nutrition enhancer, potassium nutrition enhancer, sodium nutrition enhancer, iron nutrition enhancer, copper nutrition enhancer, manganese nutrition enhancer and selenium nutrition enhancer.
Further defined, the phosphorus nutrition enhancer is one or a combination of calcium phosphate or calcium hydrophosphate;
the magnesium nutrition enhancer is one or more of magnesium gluconate, magnesium hydrogen phosphate, magnesium sulfate, magnesium carbonate, magnesium chloride and magnesium oxide;
the zinc nutrition enhancer is any one or more of zinc gluconate, zinc glycinate, zinc citrate, zinc lactate, zinc acetate, zinc sulfate, zinc carbonate, zinc chloride and zinc oxide;
the potassium nutrition enhancer is one or more of potassium gluconate, potassium citrate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate and potassium chloride;
the sodium nutrition enhancer is one or more of sodium citrate, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate and sodium chloride;
the iron nutrition enhancer is any one or more of ferrous gluconate, ferrous fumarate, ferrous citrate, ferric ammonium citrate, ferric citrate, ferrous lactate, ferrous glycinate, ferrous fumarate, ferrous succinate, ferrous sulfate, ferrous carbonate, ferric pyrophosphate, reduced iron, electrolytic iron, ferric chloride, heme iron, iron porphyrin, sodium ferric ethylene diamine tetraacetate and carbonyl iron powder;
the copper nutrition enhancer is any one or more of copper gluconate, copper citrate, copper carbonate and copper sulfate;
the manganese nutrition enhancer is any one or more of manganese gluconate, manganese citrate, manganese carbonate, manganese sulfate and manganese chloride;
the selenium nutrition enhancer is one or more of sodium selenite, sodium selenate, selenoprotein, selenium-rich edible fungus powder, and L-selenium-methyl selenocysteine.
Further limiting, the qi-invigorating and blood-nourishing component is any one or more of ginseng, codonopsis pilosula, astragalus, angelica, white paeony root, jujube, rhizoma polygonati, arillus longan, donkey-hide gelatin, mulberry and black sesame.
Further limiting, the nourishing and kidney tonifying component is any one or more of oyster, sheep penis, venison, cordyceps militaris, cordyceps guangdongensis sporocarp, prepared fleece-flower root, dogwood, sharpleaf galangal fruit, raspberry, Chinese chive seed, dodder, flatstem milkvetch seed and schisandra chinensis.
Further limited, the blood circulation promoting and blood stasis removing component is any one or more of rhizoma ligustici wallichii, peach kernel, red paeony root, cattail pollen, safflower, frankincense, myrrh, rhizoma corydalis and herba lycopi.
The composition for promoting bone health is used as an active ingredient in the aspects of foods, health-care foods or medicines for promoting bone health.
The composition for promoting bone health is used as an active ingredient in the aspects of foods, health-care foods or medicines for promoting bone health by taking the effects of promoting osteoblast proliferation and inhibiting bone resorption of osteoclast as approaches.
The composition for promoting bone health is used as an effective component in the aspects of food, health-care food or medicine for promoting bone health by taking nourishing and tonifying kidney, and activating blood and dissolving stasis as ways.
The composition for promoting bone health mainly comprises the following functional components:
(1) cucumber seeds: can promote regeneration of human body, and has effects of recovery, treatment and health promotion for osteoporosis, leg and foot cramp, rheumatism, arthritis, cervical syndrome and liver, stomach, spleen, lung, etc.; and can regulate the interaction between human organs, promote the regeneration of human cells, regulate channels and collaterals, nourish brain and cerebellum, enhance memory, and regulate the coordination and balance of human body.
(2) Egg shell: contains abundant calcium carbonate, calcium phosphate and magnesium carbonate, has the effects of astringing, relieving hyperacidity, strengthening bone, stopping bleeding, improving eyesight and the like, and particularly can maintain Ca, Ca/P and alkaline phosphatase in the normal range of animal serum; the calcium is used as the source of active calcium, and has good absorption and utilization effects in vivo.
(3) Human placenta: the placenta refers to human placenta, and the placenta is sweet in taste, salty and warm in nature, enters lung, heart and kidney channels, has the effects of tonifying kidney and essence, tonifying qi and nourishing blood, and has a great effect on renal osteopathia according to traditional Chinese medicine. Modern medical research believes that the placenta contains protein, sugar, calcium, vitamins, immune factors and the like, can enhance the immunity of a human body, and is beneficial to improving bone health diseases.
(4) Almond oil with long stalk: contains natural antioxidant and omega-3 fatty acid, and is helpful for human body to absorb minerals such as calcium, phosphorus, zinc, etc., thereby promoting bone growth; omega-3 fatty acids also help to maintain bone density, reduce osteoporosis due to free radicals (highly reactive molecules); can also reduce the speed of blood clot formation and promote blood circulation by increasing the content of omega-3 fatty acid in the body.
(5) Eucommia seed oil: tonify middle energizer, replenish essence and qi, improve lumbago, tonify kidney, strengthen tendons and bones.
(6) The hydrolyzed yolk powder is functional polypeptide, is easy to fuse with milk, and can stimulate the generation of bone growth factors IGF1 and TGFB1 by stimulating the germ cells of the cereal, inhibit the secretion of osteoclast division factors IL-1, IL-6 and TNF α, maintain the balance of bone components, promote the utilization of calcium, inhibit the loss of calcium and the like, thereby achieving the effect of stimulating the growth of bones.
(7) Calcium fortifier: contains some calcium sources which are easy to be absorbed by human body, and has the effects of supplementing calcium and strengthening bone.
(8) Vitamin D: is beneficial to the absorption of calcium in intestinal tract, can promote the reabsorption of the renal proximal convoluted tubule on calcium, can promote the osteogenesis and can ensure the deposition of bone calcium. The ingestion of sufficient vitamin D is the basis for ensuring effective prevention and treatment of osteoporosis and bone trauma rehabilitation.
(9) Vitamin C: not only can promote the deposition of calcium salt, but also can participate in proline hydroxylation reaction and promote the synthesis of ossein. The deficiency can cause collagen synthesis disorder, so that bone organic matter is formed badly, thereby causing osteoporosis and other diseases and influencing bone wound healing.
(10) β -hydroxy- β -methylbutanoic acid calcium can enhance nitrogen fixation ability of human body, maintain protein level in human body, especially play an important role in protein synthesis of muscle tissue, reduce muscle protein consumption, help muscle recovery and reduce muscle damage caused by overwork, thereby indirectly protecting bone health, improving exercise intensity and endurance, enhancing human body immunity, reducing cholesterol, and improving body constitution.
(11) Glucosamine sulfate salt: glucosamine is a derivative of a natural amino monosaccharide and is an essential component in cartilage matrix for the synthesis of proteoglycan. Proteoglycan can make the articular cartilage have the function of absorbing impact force by suppressing the tensile force of collagen fibers. The amino monosaccharide can stimulate chondrocytes to produce glycoproteins with normal polymer structures, inhibit enzymes (e.g., collagenase) that can damage articular cartilage, prevent damage to chondrocytes from corticosteroids and certain non-steroidal anti-inflammatory drugs, and reduce the release of endotoxic factors from damaged cells. Glucosamine also has antioxidant effect and inhibits the production of superoxide radicals in damaged cells in animal models of arthritis, and through the above-mentioned route, glucosamine exerts a direct anti-inflammatory effect, can relieve the pain symptoms of osteoarthritis, improve joint function, and can prevent the development of the course of osteoarthritis.
(12) Chondroitin sulfate: the main application way in medicine is that the medicine is used as a medicine for treating joint diseases, is matched with glucosamine, and has the effects of relieving pain and promoting cartilage regeneration.
(13) Hyaluronic acid: relieving arthritis, accelerating wound healing and promoting bone health.
(14) Auxiliary bone strengthening components: contains saccharides, proteins, fats, vitamins, mineral elements, etc., has the functions of promoting calcium absorption, reducing calcium and phosphorus loss, reducing muscle protein consumption, promoting bone cell proliferation and collagen synthesis, increasing bone density, promoting cartilage growth, resisting inflammation, etc., and is an important auxiliary component for improving bone health.
(15) The qi-tonifying and blood-nourishing components: nourishing primordial qi, promoting fluid production, nourishing blood, tranquilizing mind, improving intelligence, improving symptoms of deficiency of qi and blood, asthenia, and asthenia due to prolonged illness, improving body constitution, enhancing immunity, and preventing diseases related to bone health.
(16) Nourishing and tonifying kidney components: the plain questions and the six-joint elephant treatise say that the kidney is filled in the bone, and the plain questions and the four-hour spur and inverse theory say that the kidney governs the bone marrow, so the kidney is the congenital source, and the deficiency of kidney essence is the root cause of the malnutrition of the bone, so the nourishing and tonifying the kidney has great significance for promoting the bone health.
(17) Blood circulation promoting and stasis removing components: blood stasis blocking collaterals and blood stasis and turbidity obstruction are the root causes of bone impediment diseases, and the key points of preventing and treating the diseases are activating blood and dissolving stasis.
The composition for promoting bone health takes cucumber seeds, egg shells, human placenta, almond oil, eucommia seed oil, hydrolyzed yolk powder, calcium nutrition enhancer and the like as main raw materials, so that the characteristics of the ingredients are fully exerted, and the ingredients take effect in a synergistic way, and compared with the prior art, the composition mainly has the following beneficial effects:
(1) the composition for promoting bone health can be used as a main component to be applied to the fields of food, health food or medicines, and is a good choice for nourishing, regulating and maintaining body health.
(2) The invention adds the common ingredients of cucumber seed, egg shell and human placenta for strengthening the body and strengthening the bone, the ingredients are proved to be safe and effective by long-term folk practice, and then the ingredients are compatible with almond oil, eucommia seed oil, hydrolyzed egg yolk powder, calcium nutrition enhancer, vitamin D, vitamin C, β -hydroxy- β -methylbutyrate calcium, glucosamine sulfate, chondroitin sulfate, hyaluronic acid and the like to prepare the composition for promoting the bone health.
(3) The composition is different from common calcium supplement products and not only supplements the calcium nutrient components, but also aims at tonifying the kidney, strengthening the body, promoting blood circulation and removing meridian obstruction so as to prevent and improve bone health diseases and reduce the possibility of occurrence of the bone health diseases by utilizing the immune regulation function of the human body, thereby realizing the aim of promoting the bone health by mainly self-regulating and treating as auxiliary.
(4) The invention comprehensively conditions from multiple aspects of calcium supplement, anti-inflammation, analgesia, nourishing, kidney tonifying, blood circulation promoting and the like, so that the organism can be fundamentally improved, the exertion level of body functions is improved, and the absorption of various nutrient components is promoted.
Detailed Description
The technical solution of the present invention will be further described with reference to examples and experiments, but the present invention is not limited to the following embodiments.
The invention adds the nourishing components common in folk, such as cucumber seeds, egg shells and human placenta, the components are safe and effective after long-term folk practice, and are compatible with the Amygdalus pedunculatus pall oil, the eucommia ulmoides seed oil, the hydrolyzed egg yolk powder, the calcium nutrition enhancer, the vitamin D, the vitamin C, β -hydroxy- β -calcium methylbutyrate, glucosamine sulfate, chondroitin sulfate, hyaluronic acid, the auxiliary bone strengthening component, the qi and blood tonifying component, the nourishing and kidney tonifying component and the blood circulation promoting and blood stasis removing component to prepare the composition for promoting the bone health.
The composition for promoting bone health of the present invention can be prepared into food, health food or pharmaceutical forms such as powder, granule, capsule, tablet, emulsion, etc. according to conventional processes.
3-15 parts of cucumber seeds, 3-15 parts of egg shells, 1-6 parts of human placenta, 1-4 parts of almond oil with long handle, 0.5-3 parts of eucommia seed oil, 0.3-1 part of hydrolyzed egg yolk powder and 0.1-1 part of calcium nutrition enhancer.
Example 1
The composition for promoting bone health in the embodiment is prepared from 7g of cucumber seeds, 8g of eggshells, 2g of human placenta, 3g of Chinese date, 4g of astragalus membranaceus, 3g of almond oil, 1g of eucommia seed oil, 0.6g of hydrolyzed egg yolk powder, 0.22g of calcium hydrophosphate, 0.39g of calcium oxide, and vitamin D30.000013g, L-ascorbic acid 0.1g, cottonseed oligosaccharide 3g, calcium β -hydroxy- β -methylbutyrate 2g and casein phosphopeptide 0.035 g.
The specific preparation method comprises the following steps:
(1) adding 3-5 times of pure water into cucumber seeds, eggshells, placenta hominis, Chinese dates and astragalus membranaceus, soaking for 2 hours, decocting for 2 times, decocting for 2 hours each time, filtering after each decoction, separating liquid medicine, combining the two filtrates, standing for 6-8 hours, and taking supernatant; concentrating the supernatant under reduced pressure at-0.07 MPa and 55-60 ℃ until the relative density is 1.22 at 50 ℃, adding a 95% ethanol solution with the volume of 3-5 times that of the concentrated solution, fully stirring, standing for 36-48 h, filtering, taking a filtrate, washing medicine residues with the 60% ethanol solution, combining a washing solution and the filtrate, and concentrating under reduced pressure at-0.07 MPa and 55-60 ℃ to obtain a clear paste with the relative density of 1.35 at 50 ℃; drying the clear paste under reduced pressure at-0.085 MPa and 55-70 ℃, and crushing the dried paste into dry paste powder for later use.
(2) The method comprises the steps of preparing 4% (w/v) β -cyclodextrin solution, taking β -cyclodextrin as a wall material, carrying out magnetic stirring on the oily sample and β -cyclodextrin solution in a water bath at 40-50 ℃ for 1-2 hours according to a mass ratio of 1:6 to obtain primary embedding liquid, keeping the primary embedding liquid in a uniform state under magnetic stirring, pumping the primary embedding liquid into a dryer, carrying out spray drying at an air inlet temperature of 150 ℃ and a feeding amount of 40mL/min to obtain primary embedding powder, preparing 6% -10% (w/v) zein solution, taking zein as a wall material for secondary embedding, carrying out normal-temperature spray embedding on the prepared embedding powder, uniformly embedding, air-drying alcohol, collecting, cooling, recovering the alcohol, placing the powder of the zein secondary powder at 50-70 ℃ for drying for 30-50 min, and cooling to room temperature in the dryer for later use.
(3) Mixing (1) and (2), adding hydrolyzed egg yolk powder, calcium hydrogen phosphate, calcium oxide, and vitamin D3L-ascorbic acid, cottonseed oligosaccharide, β -hydroxy- β -calcium methylbutyrate and casein phosphopeptide are stirred to be fully and uniformly mixed, sieved by a 100-mesh sieve and subpackaged to obtain a powdery finished product (10g per bag, 2 times a day and 1 bag each time).
The composition for promoting bone health prepared by the embodiment has good effects of supplementing calcium and promoting calcium absorption, and can effectively alleviate common bone health problems caused by calcium loss.
Example 2
The composition for promoting bone health in the embodiment is prepared from raw materials including 6g of cucumber seeds, 6g of eggshells, 2g of human placenta, 6g of semen cuscutae, 4g of red peony roots, 6g of angelica sinensis, 3g of astragalus membranaceus, 2g of almond oil, 1g of eucommia seed oil, 0.8g of hydrolyzed egg yolk powder, 1g of calcium acetate, 0.4g of milk mineral salt, 0.07g of colostrum basic protein, 1g of bovine collagen peptide, 0.049g of casein phosphopeptide, 0.01g of zinc oxide, and vitamin D30.000012g, vitamin A0.00075 g, vitamin K20.00006g, 0.3g of chitosan oligosaccharide and 1.5g of milk fat.
The specific preparation method comprises the following steps:
(1) adding 3-5 times of pure water into cucumber seeds, eggshells, placenta hominis, semen cuscutae, radix paeoniae rubra, angelica sinensis and astragalus membranaceus, soaking for 2 hours, decocting for 2 times, decocting for 2 hours each time, filtering after each time of decoction, separating liquid medicine, combining filtrates of the two times, standing for 6-8 hours, and then taking supernatant; concentrating the supernatant under reduced pressure at-0.07 MPa and 55-60 ℃ until the relative density is 1.22 at 50 ℃, adding a 95% ethanol solution with the volume of 3-5 times that of the concentrated solution, fully stirring, standing for 36-48 h, filtering, taking a filtrate, washing medicine residues with the 60% ethanol solution, combining a washing solution and the filtrate, and concentrating under reduced pressure at-0.07 MPa and 55-60 ℃ to obtain a clear paste with the relative density of 1.35 at 50 ℃; drying the clear paste under reduced pressure at-0.085 MPa and 55-70 ℃, and crushing the dried paste into dry paste powder for later use.
(2) The method comprises the steps of preparing 4% (w/v) β -cyclodextrin solution, taking β -cyclodextrin as a wall material, carrying out magnetic stirring on the oily sample and β -cyclodextrin solution in a water bath at 40-50 ℃ for 1-2 hours according to a mass ratio of 1:6 to obtain primary embedding liquid, keeping the primary embedding liquid in a uniform state under magnetic stirring, pumping the primary embedding liquid into a dryer, carrying out spray drying at an air inlet temperature of 150 ℃ and a feeding amount of 40mL/min to obtain primary embedding powder, preparing 6% -10% (w/v) zein solution, taking zein as a wall material for secondary embedding, carrying out normal-temperature spray embedding on the prepared embedding powder, uniformly embedding, air-drying alcohol, collecting, cooling, recovering the alcohol, placing the powder of the zein secondary powder at 50-70 ℃ for drying for 30-50 min, and cooling to room temperature in the dryer for later use.
(3) Mixing (1) and (2) uniformly, adding hydrolyzed yolk powder, calcium acetate, milk mineral salt, colostrum basic protein, bovine collagen peptide, casein phosphopeptide, zinc oxide, and vitamin D3Vitamin A, vitamin K2Mixing chitosan oligosaccharide and milk fat, stirring, sieving with 100 mesh sieve, and packaging to obtain powder product (10 g/bag, 2 times per day, 1 bag per time).
The composition for promoting bone health prepared in this embodiment has the outstanding effects of promoting bone cell proliferation and bone growth, increasing bone density, inhibiting bone resorption of osteoclasts, effectively reducing bone cell destruction and the like by increasing components such as proteins (collagen peptides, hydrolyzed egg yolk powder and the like), minerals, vitamins and the like, and can effectively improve related bone health problems caused by too low bone mass.
Example 3
The composition for promoting bone health in the embodiment is prepared from raw materials including cucumber seeds 5g, eggshells 5g, placenta hominis 2g, fructus alpiniae oxyphyllae 4g, cattail pollen 3g, myrrh 3g, donkey-hide gelatin 4g, flat peach oil 2g, eucommia seed oil 0.8g, hydrolyzed egg yolk powder 0.5g, calcium phosphate 1.55g, calcium carbonate 0.26g, non-denatured type II collagen 1g, glucosamine potassium sulfate 0.6g, chondroitin sulfate 0.12g, hyaluronic acid 0.15g, vitamin D20.000011g, trehalose 1.5g and lecithin 2 g.
The specific preparation method comprises the following steps:
(1) adding 3-5 times of pure water into cucumber seeds, eggshells, placenta hominis, fructus alpiniae oxyphyllae, pollen typhae, myrrh and donkey-hide gelatin, soaking for 2 hours, decocting for 2 times, decocting for 2 hours each time, filtering after each decoction, separating liquid medicine, combining filtrates of the two times, standing for 6-8 hours, and then taking supernatant; concentrating the supernatant under reduced pressure at-0.07 MPa and 55-60 ℃ until the relative density is 1.22 at 50 ℃, adding a 95% ethanol solution with the volume of 3-5 times that of the concentrated solution, fully stirring, standing for 36-48 h, filtering, taking a filtrate, washing medicine residues with the 60% ethanol solution, combining a washing solution and the filtrate, and concentrating under reduced pressure at-0.07 MPa and 55-60 ℃ to obtain a clear paste with the relative density of 1.35 at 50 ℃; drying the clear paste under reduced pressure at-0.085 MPa and 55-70 ℃, and crushing the dried paste into dry paste powder for later use.
(2) Preparing β -cyclodextrin solution of 4% (w/v), taking β -cyclodextrin as a wall material, carrying out magnetic stirring on the amygdalus pedunculata pall oil sample and β -cyclodextrin solution for 1 to 2 hours in water bath at 40 to 50 ℃ according to the mass ratio of 1:6 to obtain primary embedding liquid, keeping the primary embedding liquid in a uniform state under magnetic stirring, pumping the primary embedding liquid into a dryer, carrying out spray drying at the condition that the air inlet temperature is 150 ℃ and the feeding amount is 40mL/min to obtain primary embedding powder, preparing zein solution of 6 to 10% (w/v), taking zein as a wall material for secondary embedding, carrying out normal-temperature spray embedding on the prepared primary embedding powder, uniformly embedding, air-drying alcohol, collecting, cooling and recovering the alcohol, drying the powder of the zein secondary embedding at 50 to 70 ℃ for 30 to 50min, cooling the powder to room temperature in the dryer for later use.
(3) Mixing (1) and (2), adding hydrolyzed yolk powder, calcium phosphate, calcium carbonate, non-denatured II type collagen, glucosamine potassium sulfate, chondroitin sulfate, hyaluronic acid, and vitamin D2Mixing trehalose and lecithin under stirring, and sieving with 80 mesh sieve; adding microcrystalline cellulose accounting for 1 percent of the total powder mass and maltodextrin accounting for 2 percent of the total powder mass, uniformly mixing, using 60 to 75 percent of ethanol as a wetting agent with the dosage of 8 to 10 percent, and granulating; drying at 55-60 ℃ until the moisture content is lower than 5%, sieving the dried granules with a 16-mesh sieve for grading, adding magnesium stearate with the mass of 1% of the whole granules, and mixing; tabletting the total mixture to obtain tablet (1 g/tablet, 3 times daily, 6 tablets each time).
The composition for promoting bone health prepared in the embodiment can relieve pain of bone diseases, resist inflammation and pain and improve related bone health problems caused by inflammation by adding components such as proteins (non-denatured type II collagen), glucosamine sulfate, chondroitin sulfate, hyaluronic acid and the like.
Example 4
The composition for promoting bone health in the embodiment is prepared from raw materials including 6g of cucumber seeds, 4g of eggshells, 4g of human placenta, 4g of oysters, 4g of cordyceps militaris, 3g of sheep penis, 5g of frankincense, 5g of safflower, 2g of ginseng, 4g of rhizoma polygonati, 1.5g of almond oil, 2g of eucommia seed oil, 0.6g of hydrolyzed egg yolk powder, 1g of calcium lactate and vitamin D30.00001g, vitamin K20.00005g, 2g of cottonseed oligosaccharide and 1.5g of lecithin.
The specific preparation method comprises the following steps:
(1) adding 3-5 times of pure water into cucumber seeds, eggshells, placenta hominis, oysters, cordyceps militaris, sheep penis, frankincense, safflower, ginseng and rhizoma polygonati, soaking for 2 hours, decocting for 2 times, decocting for 2 hours each time, filtering after each decoction is finished, separating liquid medicine, combining two filtrates, standing for 6-8 hours, and then separating supernatant; concentrating the supernatant under reduced pressure at-0.07 MPa and 55-60 ℃ until the relative density is 1.22 at 50 ℃, adding a 95% ethanol solution with the volume of 3-5 times that of the concentrated solution, fully stirring, standing for 36-48 h, filtering, taking a filtrate, washing medicine residues with the 60% ethanol solution, combining a washing solution and the filtrate, and concentrating under reduced pressure at-0.07 MPa and 55-60 ℃ to obtain a clear paste with the relative density of 1.35 at 50 ℃; drying the clear paste under reduced pressure at-0.085 MPa and 55-70 ℃, and crushing the dried paste into dry paste powder for later use.
(2) The method comprises the steps of preparing 4% (w/v) β -cyclodextrin solution, taking β -cyclodextrin as a wall material, carrying out magnetic stirring on the oily sample and β -cyclodextrin solution in a water bath at 40-50 ℃ for 1-2 hours according to a mass ratio of 1:6 to obtain primary embedding liquid, keeping the primary embedding liquid in a uniform state under magnetic stirring, pumping the primary embedding liquid into a dryer, carrying out spray drying at an air inlet temperature of 150 ℃ and a feeding amount of 40mL/min to obtain primary embedding powder, preparing 6% -10% (w/v) zein solution, taking zein as a wall material for secondary embedding, carrying out normal-temperature spray embedding on the prepared embedding powder, uniformly embedding, air-drying alcohol, collecting, cooling, recovering the alcohol, placing the powder of the zein secondary powder at 50-70 ℃ for drying for 30-50 min, and cooling to room temperature in the dryer for later use.
(3) Will be provided with(1) Mixing with the mixture obtained in step (2), adding hydrolyzed yolk powder, calcium lactate, and vitamin D3Vitamin K2Mixing the cottonseed oligosaccharide and lecithin uniformly, stirring to mix uniformly, using 8-10% ethanol as wetting agent, granulating with 14 mesh sieve, drying at 55-60 deg.C until the water content is lower than 5%, double sieving with 12-20 mesh sieve, and packaging to obtain granular finished product (10 g/bag, 2 times per day, 1 bag per time).
The composition for promoting bone health prepared in the embodiment can fundamentally condition the organism and prevent and improve bone health problems related to bone flaccidity by adding components for nourishing and tonifying the kidney and components for tonifying qi and nourishing blood.
Example 5
The composition for promoting bone health in the embodiment is prepared from raw materials including 4g of cucumber seeds, 5g of egg shells, 3g of human placenta, 3g of ligusticum wallichii, 4g of peach kernels, 4g of rhizoma corydalis, 6g of semen astragali complanati, 5g of raspberry, 4g of herba lycopi, 2g of codonopsis pilosula, 5g of mulberry, 2g of Amygdalus pedunculata Maxim oil, 1.5g of eucommia seed oil, 0.6g of hydrolyzed egg yolk powder, 1g of calcium sulfate, and vitamin D20.000011g, magnesium ascorbyl phosphate 0.08g, trehalose 1g, fish collagen 0.8g and elastin peptide 0.8 g.
The specific preparation method comprises the following steps:
(1) adding 3-5 times of pure water into cucumber seeds, egg shells, human placenta, ligusticum wallichii, peach kernels, rhizoma corydalis, semen astragali complanati, raspberry, herba lycopi, codonopsis pilosula and mulberry, soaking for 2 hours, decocting for 2 times, decocting for 2 hours each time, filtering after each decoction is finished, separating liquid medicine, combining two filtrates, standing for 6-8 hours, and then taking supernatant; concentrating the supernatant under reduced pressure at-0.07 MPa and 55-60 ℃ until the relative density is 1.22 at 50 ℃, adding a 95% ethanol solution with the volume of 3-5 times that of the concentrated solution, fully stirring, standing for 36-48 h, filtering, taking a filtrate, washing medicine residues with the 60% ethanol solution, combining a washing solution and the filtrate, and concentrating under reduced pressure at-0.07 MPa and 55-60 ℃ to obtain a clear paste with the relative density of 1.35 at 50 ℃; drying the clear paste under reduced pressure at-0.085 MPa and 55-70 ℃, and crushing the dried paste into dry paste powder for later use.
(2) The method comprises the steps of preparing 4% (w/v) β -cyclodextrin solution, taking β -cyclodextrin as a wall material, carrying out magnetic stirring on the oily sample and β -cyclodextrin solution in a water bath at 40-50 ℃ for 1-2 hours according to a mass ratio of 1:6 to obtain primary embedding liquid, keeping the primary embedding liquid in a uniform state under magnetic stirring, pumping the primary embedding liquid into a dryer, carrying out spray drying at an air inlet temperature of 150 ℃ and a feeding amount of 40mL/min to obtain primary embedding powder, preparing 6% -10% (w/v) zein solution, taking zein as a wall material for secondary embedding, carrying out normal-temperature spray embedding on the prepared embedding powder, uniformly embedding, air-drying alcohol, collecting, cooling, recovering the alcohol, placing the powder of the zein secondary powder at 50-70 ℃ for drying for 30-50 min, and cooling to room temperature in the dryer for later use.
(3) Mixing (1) and (2), adding hydrolyzed egg yolk powder, calcium sulfate, and vitamin D2Vitamin C phosphate magnesium, trehalose, fish collagen and elastin peptide are stirred to be fully and uniformly mixed, 60-75% of ethanol is used as a wetting agent, the using amount is 8-10%, and granulation is carried out; drying at 55-60 deg.C until the water content is less than 5%, sieving the dried granules with 16 mesh sieve, grading, and making into capsule to obtain capsule-shaped product (1 g/granule, 3 times per day, 6 granules each time).
The composition for promoting bone health prepared by the embodiment can fundamentally regulate body functions and prevent and improve bone health problems related to bone impediment by adding components for promoting blood circulation to remove blood stasis and components for benefiting qi and nourishing blood.
Example 6
The composition for promoting bone health in the embodiment is prepared from raw materials including 6g of cucumber seeds, 7g of egg shells, 3g of human placenta, 3g of almond oil, 2g of eucommia seed oil, 1.5g of palm oil and vitamin D30.000013g, vitamin K20.00006g, 0.1g of calcium bicarbonate, 0.8g of calcium gluconate, 0.1g of β -hydroxy- β -methylbutyrate calcium, 0.6g of glucosamine potassium sulfate, 0.12g of chondroitin sulfate, 0.15g of hyaluronic acid, 0.8g of hydrolyzed egg yolk powder and 0.049g of casein phosphopeptide.
The specific preparation method comprises the following steps:
(1) the Chinese herbal medicine components: adding 3-5 times of pure water into cucumber seeds, eggshells and placenta hominis, soaking for 2h, decocting for 2 times, each time for 2h, filtering after each decoction, separating liquid medicine, combining two filtrates, filtering, and concentrating the filtrate to 50% of the original volume to obtain Chinese herbal medicine juice for later use.
(2) Oil phase: almond oil, eucommia seed oil, soybean lecithin and vitamin D3Vitamin K2. And uniformly mixing under the protection of nitrogen for later use.
(3) The water phase comprises calcium bicarbonate, calcium gluconate, β -hydroxy- β -calcium methylbutyrate, glucosamine potassium sulfate, chondroitin sulfate, hyaluronic acid, hydrolyzed yolk powder and casein phosphopeptide, is dissolved in pure water at 60 ℃, and is uniformly stirred for later use.
(4) Mixing the Chinese herbal medicine juice and the water phase under the protection of nitrogen, adding the oil phase by stirring and vortex, violently stirring to form an oil-in-water emulsion, and preparing the emulsion by high shearing; repeatedly homogenizing the emulsion with a high pressure homogenizer to obtain oral emulsion with particle size less than 500 nm; filtering the nano emulsion with 0.5 μm filter membrane, bottling, charging nitrogen, and sealing; and sterilizing in an autoclave at 115 deg.C for 30min to obtain emulsion (30 mL/bottle, 3 times per day, 1 bottle each time).
Example 7
The composition for promoting bone health of the embodiment is prepared from raw materials including 3g of cucumber seeds, 15g of egg shells, 6g of human placenta, 1g of almond oil, 0.5g of eucommia seed oil, 1.5g of soybean oil, and cholecalciferol (vitamin D)3)0.000015g, 0.00006g of magnesium ascorbyl phosphate, 0.04g of L-calcium ascorbate, 1g of calcium bicarbonate, 2.24g of calcium gluconate, 1g of β -hydroxy- β -methylbutyrate calcium, 0.3g of glucosamine sulfate sodium salt, 0.076g of chondroitin sulfate, 0.08g of hyaluronic acid, 0.3g of hydrolyzed egg yolk powder and 0.049g of casein phosphopeptide.
Example 8
The composition for promoting bone health in the embodiment is prepared from 15g of cucumber seeds, 3g of eggshells, 1g of human placenta, 4g of pedunculate almond oil, 3g of eucommia ulmoides seed oil, 1g of hydrolyzed yolk powder, 0.1g of chicken bone meal, 0.000005g of ergocalciferol (vitamin D2), 0.2g of ascorbyl palmitate, 3g of β -hydroxy- β -calcium methylbutyrate, 0.7g of glucosamine potassium sulfate, 0.13g of chondroitin sulfate, 0.2g of hyaluronic acid, 0.00003g of magnesium chloride, 5g of mulberries, 5g of white peony roots, 5g of black sesame, 0.5g of oysters, 0.5g of sheep penis, 5g of venison, 5g of cordyceps militaris, 9g of cordyceps guangdongensis fruiting bodies, 0.5g of peach kernels, 0.5g of red paeony roots and 1g of cattail pollen, and can be prepared into a gel finished product according to the preparation method in the embodiment.
Example 9
The bone health promoting composition of this example was prepared from 10g cucumber seeds, 6g eggshells, 3g human placenta, 2g almond oil, 1g eucommia seed oil, 0.5g hydrolyzed egg yolk powder, 0.3g Os Draconis powder, 0.7g calcium L-threonate, 0.000005g ergocalciferol (vitamin D2), 0.04g ascorbyl palmitate, 0.04g calcium L-ascorbate, 0.04g sodium L-ascorbate, 3g calcium β -hydroxy- β -methylbutyrate, 0.7g potassium glucosamine sulfate, 0.13g chondroitin sulfate, 0.2g hyaluronic acid, 0.00003g xylo-oligosaccharide, 1g basic protein, 2g coconut oil, 0.5g vitamin A, 0.5g zinc glycinate, 0.21 g rhizoma Polygonati, 0.37 g aril, 0.42, 0.2g donkey-hide gelatin, 0.2, 0.25 g fructus Corni, 0.25, 0.5g raspberry, 0.5g vitamin A, 0.5g zinc glycinate, 0.21, 0.34 g myrrh, and the aforementioned processed rhizoma corydalis oral liquid.
Example 10
The composition for promoting bone health in the embodiment is prepared from raw materials including 10g of cucumber seeds, 6g of eggshells, 3g of human placenta, 2g of pedunculate amygdalus pedunculata oil, 1g of eucommia ulmoides seed oil, 0.5g of hydrolyzed egg yolk powder, 0.3g of keel powder, 0.7g of calcium L-threonate, 0.000005g of ergocalciferol (vitamin D2), and cholecalciferol (vitamin D)3)0.00001 g of L-ascorbic acid, 0.04g of L-calcium ascorbate, 0.04g of L-potassium ascorbate, 2g of β -hydroxy- β -calcium methylbutyrate, 0.5g of potassium glucosamine sulfate, 0.1g of chondroitin sulfate, 0.1g of hyaluronic acid, 0.00003g of xylooligosaccharide, 1g of colostrum basic protein, 2g of coconut oil, 0.5g of vitamin A, 0.5g of zinc glycinate, 2g of ginseng, 3g of codonopsis pilosula, 10g of astragalus, 0.2g of semen allii tuberosi, 1g of semen cuscutae, 2g of semen astragali complanati, 5g of schisandra chinensis, 1g of safflower and 3g of frankincense according to the proportionThe preparation method of the previous embodiment is used for preparing a sheet-shaped finished product.
The calcium hydrogen phosphate, calcium carbonate, etc. in the above embodiments can be used as a calcium nutrition enhancer, and can be replaced by any one of milk mineral salt, calcium gluconate, calcium lactate, L-calcium lactate, calcium citrate, calcium acetate, calcium L-threonate, calcium glycinate, calcium aspartate, calcium citrate malate, calcium vitamin E succinate, calcium sulfate, calcium chloride, calcium oxide, calcium phosphate, calcium glycerophosphate, Os Draconis powder, chicken bone powder, and pig bone powder, or can be used in combination, and the usage amount is 0.1-1 parts by weight.
The xylo-oligosaccharide in the above embodiment is used as a saccharide component, and can be replaced by any one or a combination of several of glucose, fructose, maltose, lactose, sucrose, starch, cellulose, pectin, resistant dextrin, fructo-oligosaccharide, isomaltose oligosaccharide, isomaltulose, raffinose oligosaccharide, polydextrose, stachyose, chitosan oligosaccharide and trehalose, and the xylo-oligosaccharide is used as an auxiliary bone-strengthening component and plays a role in assisting bone-bonding, and the usage amount of the xylo-oligosaccharide is 0.00003-15 parts by weight.
The lactoferrin and the casein phosphopeptide in the above embodiment can be replaced by one or more of colostrum basic protein, non-denatured type II collagen, cartilage collagen, fish collagen, bovine collagen peptide, elastin peptide, and oyster peptide, and the usage amount is 0.00003-15 parts by weight.
The soybean oil and lecithin in the above embodiments can be replaced by one or more of peanut oil, corn oil, soybean oil, sunflower seed oil, palm oil, coconut oil, lecithin and milk fat, and the usage amount is 0.00003-15 parts by weight.
Vitamin A, vitamin K of the above examples2As other vitamin components, vitamin B can be used6Vitamin B12Folic acid, etc. in an amount of 0.00003-15 parts by weight.
The magnesium chloride and the zinc lactate in the embodiment are used as mineral elements, and the mineral elements can be any one or more of a phosphorus nutrition enhancer, a magnesium nutrition enhancer, a zinc nutrition enhancer, a potassium nutrition enhancer, a sodium nutrition enhancer, an iron nutrition enhancer, a copper nutrition enhancer, a manganese nutrition enhancer and a selenium nutrition enhancer. Wherein the magnesium nutrition enhancer is one or more of magnesium gluconate, magnesium hydrogen phosphate, magnesium sulfate, magnesium carbonate, magnesium chloride, and magnesium oxide; the zinc nutrition enhancer is any one or more of zinc gluconate, zinc glycinate, zinc citrate, zinc lactate, zinc acetate, zinc sulfate, zinc carbonate, zinc chloride and zinc oxide; the potassium nutrition enhancer is one or more of potassium gluconate, potassium citrate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate and potassium chloride; the sodium nutrition enhancer is one or more of sodium citrate, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate and sodium chloride; the iron nutrition enhancer is any one or more of ferrous gluconate, ferrous fumarate, ferrous citrate, ferric ammonium citrate, ferric citrate, ferrous lactate, ferrous glycinate, ferrous fumarate, ferrous succinate, ferrous sulfate, ferrous carbonate, ferric pyrophosphate, reduced iron, electrolytic iron, ferric chloride, heme iron, iron porphyrin, sodium ferric ethylene diamine tetraacetate and carbonyl iron powder; the copper nutrition enhancer is any one or more of copper gluconate, copper citrate, copper carbonate and copper sulfate; the manganese nutrition enhancer is any one or more of manganese gluconate, manganese citrate, manganese carbonate, manganese sulfate and manganese chloride; the selenium nutrition enhancer is one or more of sodium selenite, sodium selenate, selenoprotein, selenium-rich edible fungus powder, and L-selenium-methyl selenocysteine. The amount of the mineral elements is 0.00003 to 15 parts by weight.
In the technical scheme of the invention, saccharides, proteins, fats, vitamins and mineral elements are used as auxiliary bone strengthening components to achieve the aim of assisting bone strengthening, and the saccharides, the proteins, the fats, the vitamins and the mineral elements can be used singly or in combination, and the total usage amount is not more than 15 parts by weight in the whole formula.
In order to evaluate the eating effect of the bone health promoting composition of the present invention, the following tests were performed.
Test example 1: eating effect for children
The growth and the metabolic capacity of the human body are extremely vigorous in the golden period of the growth and the development of the human body in the children period, and meanwhile, the demands for materials and energy are most urgent, so that the life is influenced once the demand is lacked, and great hidden danger is brought to the subsequent normal life. Bone health is the key to the thriving of children, bone health diseases caused by the lack of calcium element positively affect the happy lives of millions of children, and symptoms such as children are short, poor in movement ability, irregular in teething, X-shaped or O-shaped legs and the like are common, so that the normal lives of the children are affected, and the psychology of the children is greatly injured and the children are fatigued to the whole life. Therefore, the problem of attaching importance to the bone health of children is urgent.
In the test, the height increase condition is taken as a judgment standard, 20 male children aged 8 with the height lower than 130cm (130cm is the normal average height of the male children aged 8) are selected and divided into a control group and a test group. Control group: normal diet, without any other substances than normal diet; test groups: the diet was normal, and the bone health promoting composition of example 1 was consumed at 10 g/bag 2 times daily for 1 bag. The test periods of the two groups are 60 days, the height increase condition is scored according to the following 3 standards after 60 days (full score 10: 0-2 represents the height increase of 0-0.29 cm, 3-7 represents the height increase of 0.30-0.79 cm, 8-10 represents the height increase of 0.80-1.00 cm), the average value of the scores of each group is used as the evaluation result, and the effect of the composition for promoting bone health is determined. The results are shown in table 1:
TABLE 1 eating Effect for children
Figure RE-GDA0002401670630000151
Figure RE-GDA0002401670630000161
As can be seen from Table 1: in the control group, the height of 80% of the subjects is increased by 0-0.29 cm; the height of 20 percent of subjects is increased by 0.30-0.79 cm; and the height is not increased by 0.80-1.00 cm obviously. In the test group, the height of 10% of the testees is increased by 0-0.29 cm; the height of 70% of the tested persons is increased by 0.30-0.79 cm; the height of 20 percent of subjects is increased by 0.80-1.00 cm. The average value of the eating effect of the test group is far larger than that of the control group. Therefore, the bone health promoting composition prepared in example 1 has a good calcium supplement effect, which can significantly increase the height growth rate of a short child by calcium supplement.
Test example 2: edible effect of middle-aged and old people
The middle-aged and the elderly are high-incidence people with bone health diseases, the human body at the stage is in the degeneration stage, the growth and development are extremely slow or even stopped, the metabolic capability is weakened, the autoimmunity is reduced, the original material energy of the human body is difficult to deal with the complicated body degeneration condition, and the risk of the disease occurrence is increased. Common sub-health conditions related to bone health due to deterioration of body function are: the functions of the people are slow, the joints are not flexible, the people are easy to fracture, the muscles are sore and the like, so that the functions of increasing the bone density, promoting the proliferation of bone cells and promoting the growth of bones are the keys of the people for preventing the bone health diseases.
In the test, the improvement degree of the muscular soreness symptoms is used as a judgment standard, and 20 study objects with the muscular soreness symptoms of 45-60 years old are selected and divided into a control group and a test group. Control group: normal diet, without any other substances than normal diet; test groups: the diet was normal, and the bone health promoting composition of example 2 was consumed at 10 g/bag 2 times daily for 1 bag. The test period of the two groups is 60 days, the improvement degree of the muscle soreness symptoms after 60 days is scored according to the following 3 standards (full score 10: 0-2 represents no improvement or slight improvement of the muscle soreness symptoms, 3-7 represents improvement of the muscle soreness symptoms, and 8-10 represents obvious improvement of the muscle soreness symptoms), and the average value of the scores of each group is used as an evaluation result to carry out effect theorem on the composition for promoting bone health. The results are shown in table 2:
TABLE 2 edible effect of the middle aged and the elderly
Figure RE-GDA0002401670630000162
Figure RE-GDA0002401670630000171
As can be seen from Table 2: in the control group, 60% of subjects had no or slight improvement in symptoms of muscle soreness; improvement in muscle soreness symptoms in 30% of subjects; the symptoms of muscle soreness were significantly improved in 10% of the subjects. In the test group, 20% of subjects had no or slightly improved symptoms of muscle soreness; improvement in muscle soreness symptoms in 50% of subjects; the symptoms of muscle soreness were significantly improved in 30% of the subjects. The average value of the eating effect of the test group is far larger than that of the control group. Therefore, the composition for promoting bone health prepared in example 2 has the effects of promoting bone cell proliferation and bone growth, increasing bone density, inhibiting bone resorption by osteoclasts, reducing the destruction of osteoclasts, and the like, and is significant for preventing and improving bone health diseases of the middle-aged and elderly people.
Test example 3: eating effect of patients with rheumatoid arthritis
Rheumatoid arthritis is a chronic systemic disease mainly comprising inflammatory synovitis with unknown etiology, and is characterized in that the arthritis is polyarticular, symmetrical and invasive in hand and foot small joints, often accompanied with symptoms of the extraarticular organ affected by serum rheumatoid factor positive and the like, and serious patients can cause joint deformity and even function loss. The improvement and treatment modes of the diseases mainly include anti-inflammation and analgesia.
In the test, 20 patients with rheumatoid arthritis were selected and divided into a control group and a test group, based on the degree of improvement in joint flexibility as a criterion. Control group: eating normal diet and conventional therapeutic medicine for rheumatoid arthritis; test groups: the diet was normal, and the bone health promoting composition of example 3 was consumed at 1 g/tablet, 3 times daily, 6 tablets each time. The test periods of the two groups are 60 days, the improvement degree of the joint flexibility of the patients is scored according to the following 3 standards after 60 days (full score 10: 0-2 represents that the joints are still inflexible or slightly improved, 3-7 represents that the joint flexibility is improved, and 8-10 represents that the joint flexibility is obviously improved), and the average value of the scores of each group is used as an evaluation result to carry out effect theorem on the composition for promoting the bone health. The results are shown in Table 3:
TABLE 3 eating Effect of patients with rheumatoid arthritis
Figure RE-GDA0002401670630000172
Figure RE-GDA0002401670630000181
As can be seen from Table 3: in the control group, 20% of subjects had no or slightly improved joint flexibility; improved joint mobility in 60% of subjects; joint mobility was significantly improved in 20% of subjects. In the experimental group, 30% of subjects had no or little improvement in joint flexibility; improved joint mobility in 50% of subjects; joint mobility was significantly improved in 20% of subjects. The average eating effect of the test group is close to that of the control group. Therefore, the composition for promoting bone health prepared in example 3 can sufficiently exert its anti-inflammatory and analgesic effects, and significantly improve rheumatoid arthritis conditions.
Test example 4: the edible effect of the osteoporosis patients
Osteoporosis is a systemic metabolic bone disease characterized by a decrease in bone mass and a deterioration in microstructure of bone tissue, is a systemic bone disease in which fragility of bones increases and the risk of fracture increases, is a common disease, frequently encountered disease, clinically characterized by pain, and, secondly, shortening of body length, hunchback, fracture, respiratory system disorder, and the like, in middle-aged and elderly people. The pathogenesis of osteoporosis in traditional Chinese medicine is summarized as kidney deficiency, the disease is caused by deficiency of origin and marked excess, the disease is located in kidney and related to liver, spleen and stomach, the deficiency of origin is mainly caused by kidney deficiency, and the marked excess is mainly caused by blood stasis, qi depression and phlegm. Osteoporosis is a typical representative of renal bone diseases, and the improvement mode should be mainly kidney tonifying.
In the test, 20 patients with osteoporosis were selected and divided into control group and test group based on the improvement effect of general pain symptoms. Control group: eating normal diet and taking osteoporosis conventional therapeutic medicine; test groups: diet was normal, and the bone health promoting composition of example 4 was consumed at 10 g/bag 2 times daily for 1 bag. The test period of the two groups is 60 days, the improvement condition of the whole body pain of the patient is scored according to the following 3 standards after 60 days (full score 10: 0-2 represents no improvement or slight improvement of the whole body pain symptom, 3-7 represents improvement of the whole body pain symptom, 8-10 represents obvious improvement of the whole body pain symptom), and the average value of the scores of each group is used as the evaluation result to carry out the effect theorem on the composition for promoting the bone health. The results are shown in Table 4:
TABLE 4 eating Effect of osteoporosis patients
Figure RE-GDA0002401670630000182
Figure RE-GDA0002401670630000191
As can be seen from Table 4: in the control group, 20% of subjects had no or slight improvement in the symptoms of systemic pain; improvement in systemic pain symptoms in 60% of subjects; the symptoms of systemic pain were significantly improved in 20% of subjects. In the test group, 20% of subjects had no or slight improvement in the symptoms of systemic pain; improvement in systemic pain symptoms in 70% of subjects; the symptoms of systemic pain were significantly improved in 10% of subjects. The average eating effect of the test group is close to that of the control group. Therefore, the composition for promoting bone health prepared in example 4 has good kidney-tonifying and body-building effects, and can effectively improve osteoporosis symptoms, even comparable to the conventional osteoporosis treatment drugs on the market.
Test example 5: edible effect of patients with lumbar disc herniation
The lumbar intervertebral disc consists of three parts, namely an annulus fibrosus, a nucleus pulposus and an cartilage plate, and the lumbar intervertebral disc protrusion refers to a series of symptoms of lumbago, lower limb pain and the like caused by the fact that the nucleus pulposus of the lumbar intervertebral disc protrudes out of an annulus fibrosus to press nerve roots, and is also called as lumbar intervertebral disc annulus fibrosus rupture. With the age, the lumbar intervertebral disc is degenerated, which is an important cause of prolapse of lumbar intervertebral disc. Lumbar intervertebral disc protrusion is one of the more common lumbar diseases in clinic, is frequently seen in 20-40 years old, and belongs to the category of traditional Chinese medicine bone disease arthralgia. Therefore, according to the theory of the traditional Chinese medicine bone disease, the key point for improving the prolapse of lumbar intervertebral disc is activating blood circulation to dissipate blood stasis.
In the test, 20 patients with lumbar disc herniation were selected and divided into a control group and a test group, with the improvement of lumbago symptoms as the criterion. Control group: eating normal diet and taking conventional therapeutic medicine for prolapse of lumbar intervertebral disc; test groups: the diet was normal, and the bone health promoting composition of example 5 was consumed at 1 g/granule, 3 times daily, 6 granules each time. The test period of the two groups is 60 days, the lumbago improvement condition of the patients is scored according to the following 3 standards after 60 days (full score 10: 0-2 represents no improvement or slight improvement of lumbago symptom, 3-7 represents improvement of lumbago symptom, and 8-10 represents obvious improvement of lumbago symptom), and the average value of the scores of each group is used as an evaluation result to carry out effect theorem on the composition for promoting bone health. The results are shown in Table 5:
TABLE 5 edible effect of patients with prolapse of lumbar intervertebral disc
Figure RE-GDA0002401670630000201
As can be seen from Table 5: in the control group, 10% of subjects had no or slight improvement in lumbago symptoms; improvement in lumbago symptoms in 70% of subjects; the lumbago symptoms of 20 percent of subjects are obviously improved. In the test group, 20% of subjects had no or slight improvement in lumbago symptoms; improvement in lumbago symptoms in 60% of subjects; the lumbago symptoms of 20 percent of subjects are obviously improved. The average eating effect of the test group is close to that of the control group. Therefore, the composition for promoting bone health prepared in example 5 can effectively improve and prevent lumbago caused by lumbar disc herniation by activating blood circulation to dissipate blood stasis, and is an important progress for improving bone health diseases.
In conclusion, the composition for promoting bone health, which is prepared by the invention, has the effects of obviously enhancing the physique of children and middle-aged and elderly people and changing the sub-health state of the children and the elderly people; and the composition also has a remarkable improvement effect on bone health diseases, even can be compared with related conventional treatment medicaments to a certain extent, and is expected to be developed into a hot-market product for improving the bone health diseases.

Claims (14)

1. The composition for promoting bone health is characterized by comprising the following raw material components in parts by mass:
3-15 parts of cucumber seeds, 3-15 parts of egg shells, 1-6 parts of human placenta, 1-4 parts of almond oil with long handle, 0.5-3 parts of eucommia seed oil, 0.3-1 part of hydrolyzed egg yolk powder and 0.1-1 part of calcium nutrition enhancer.
2. The composition for promoting bone health according to claim 1, wherein the raw material components further comprise any one or any combination of 0.000005 to 0.000015 parts of vitamin D, 0.04 to 0.2 parts of vitamin C, 1 to 3 parts of β -hydroxy- β -calcium methylbutyrate, 0.3 to 0.7 part of glucosamine sulfate, 0.07 to 0.13 part of chondroitin sulfate, 0.08 to 0.2 part of hyaluronic acid, 0.00003 to 15 parts of auxiliary bone-strengthening component, 1 to 15 parts of qi-tonifying and blood-nourishing component, 1 to 20 parts of nourishing kidney-tonifying component, and 2 to 20 parts of blood-activating and stasis-removing component.
3. The composition for promoting bone health according to claim 1, wherein the calcium fortifier is any one or more of milk mineral salts, calcium gluconate, calcium lactate, L-calcium lactate, calcium citrate, calcium acetate, calcium L-threonate, calcium glycinate, calcium aspartate, calcium citrate malate, calcium vitamin E succinate, calcium carbonate, calcium sulfate, calcium chloride, calcium oxide, calcium phosphate, calcium hydrogen phosphate, calcium glycerophosphate, and superfine bone powder;
the superfine bone powder is derived from one or more of Os Draconis powder, chicken bone powder or pig bone powder.
4. Composition for promoting bone health, according to claim 2, characterized in that said vitamin D is in particular one or a combination of ergocalciferol or cholecalciferol.
5. The composition for promoting bone health according to claim 2, wherein the vitamin C is any one or more of L-ascorbic acid, L-calcium ascorbate, sodium L-ascorbate, potassium L-ascorbate, magnesium ascorbyl phosphate, and ascorbyl palmitate.
6. Composition for promoting bone health according to claim 2, wherein the glucosamine sulphate is in particular one or a combination of the glucosamine sulphate potassium salt or the glucosamine sulphate sodium salt.
7. The composition for promoting bone health as claimed in claim 2, wherein the auxiliary bone-strengthening component is any one or more of saccharides, proteins, fats, other vitamins and mineral elements;
the saccharide is any one or more of glucose, fructose, maltose, lactose, sucrose, starch, cellulose, pectin, resistant dextrin, xylooligosaccharide, fructooligosaccharide, isomaltooligosaccharide, isomaltulose, raffinose oligosaccharide, polydextrose, stachyose, chitosan oligosaccharide and trehalose;
the protein is one or more of colostrum basic protein, lactoferrin, non-denatured type II collagen, cartilage collagen, fish collagen, bovine collagen peptide, elastin peptide, oyster peptide and casein phosphopeptide;
the fat is one or more of peanut oil, corn oil, soybean oil, sunflower seed oil, palm oil, coconut oil, lecithin and milk fat;
the vitamins include vitamin A and vitamin B6Vitamin B12Folic acid, vitamin K2Any one or more of them;
the mineral elements are one or more of phosphorus nutrition enhancer, magnesium nutrition enhancer, zinc nutrition enhancer, potassium nutrition enhancer, sodium nutrition enhancer, iron nutrition enhancer, copper nutrition enhancer, manganese nutrition enhancer and selenium nutrition enhancer.
8. The bone health promoting composition of claim 7, wherein the phosphorus nutrition enhancer is one or a combination of calcium phosphate or calcium hydrogen phosphate;
the magnesium nutrition enhancer is one or more of magnesium gluconate, magnesium hydrogen phosphate, magnesium sulfate, magnesium carbonate, magnesium chloride and magnesium oxide;
the zinc nutrition enhancer is any one or more of zinc gluconate, zinc glycinate, zinc citrate, zinc lactate, zinc acetate, zinc sulfate, zinc carbonate, zinc chloride and zinc oxide;
the potassium nutrition enhancer is one or more of potassium gluconate, potassium citrate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate and potassium chloride;
the sodium nutrition enhancer is one or more of sodium citrate, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate and sodium chloride;
the iron nutrition enhancer is any one or more of ferrous gluconate, ferrous fumarate, ferrous citrate, ferric ammonium citrate, ferric citrate, ferrous lactate, ferrous glycinate, ferrous fumarate, ferrous succinate, ferrous sulfate, ferrous carbonate, ferric pyrophosphate, reduced iron, electrolytic iron, ferric chloride, heme iron, iron porphyrin, sodium ferric ethylene diamine tetraacetate and carbonyl iron powder;
the copper nutrition enhancer is any one or more of copper gluconate, copper citrate, copper carbonate and copper sulfate;
the manganese nutrition enhancer is any one or more of manganese gluconate, manganese citrate, manganese carbonate, manganese sulfate and manganese chloride;
the selenium nutrition enhancer is one or more of sodium selenite, sodium selenate, selenoprotein, selenium-rich edible fungus powder, and L-selenium-methyl selenocysteine.
9. The composition for promoting bone health according to any one of claims 2 to 8, wherein the qi-invigorating and blood-nourishing component is any one or more of ginseng, codonopsis pilosula, astragalus membranaceus, angelica sinensis, radix paeoniae alba, jujube, polygonatum sibiricum, arillus longan, donkey-hide gelatin, mulberry and black sesame.
10. The composition for promoting bone health according to any one of claims 2 to 8, wherein the nourishing and kidney-tonifying component is any one or more of oyster, sheep penis, venison, cordyceps militaris, cordyceps guangdongensis sporocarp, prepared fleece flower root, dogwood, fructus alpiniae oxyphyllae, raspberry, semen allii tuberosi, semen cuscutae, semen astragali complanati and fructus schizandrae.
11. The composition for promoting bone health according to any one of claims 2 to 8, wherein the blood circulation promoting and blood stasis removing component is any one or more of ligusticum wallichii, peach kernel, red peony root, cattail pollen, safflower, frankincense, myrrh, corydalis tuber and herba lycopi.
12. Use of the bone health promoting composition of claim 1 as an active ingredient in foods, health foods or medicines for promoting bone health.
13. Use of the composition for promoting bone health according to claim 1 as an active ingredient in foods, health foods or pharmaceuticals for promoting bone health by promoting osteoblast proliferation and inhibiting bone resorption by osteoclast.
14. Use of the composition for promoting bone health according to claim 1 as an active ingredient in foods, health foods or medicines for promoting bone health by nourishing kidney and promoting blood circulation to remove blood stasis.
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CN109170916A (en) * 2018-11-02 2019-01-11 丽睿客信息科技（北京）有限公司 One kind keeps fit and healthy food compositions and preparation method thereof
CN109589883A (en) * 2019-01-15 2019-04-09 广州城市职业学院 A kind of preparation method of plants essential oil powder microcapsules

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* Cited by examiner, † Cited by third party
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CN111513138A (en) * 2020-05-26 2020-08-11 多加多乳业(天津)有限公司 Sialic acid-containing formula milk powder for middle-aged and elderly people and preparation method thereof
CN111955722A (en) * 2020-08-05 2020-11-20 山东明仁福瑞达制药股份有限公司 Medical nutrition meal composition beneficial to medicine absorption and recovery and used for rehabilitation of osteopathic patients and medical nutrition meal
CN112316105A (en) * 2020-11-17 2021-02-05 琛蓝(美国)营养制品股份有限公司 Compound composition with function of promoting bone health and preparation method and application thereof
CN113398241A (en) * 2020-12-31 2021-09-17 江中药业股份有限公司 Bone peptide composition, bone peptide tablet, preparation method and evaluation method
CN118415357A (en) * 2024-07-05 2024-08-02 浙江衡美健康科技股份有限公司 Protein composition for promoting thickening of muscle fibers after strength training

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