CN111955722A - Medical nutrition meal composition beneficial to medicine absorption and recovery and used for rehabilitation of osteopathic patients and medical nutrition meal - Google Patents
Medical nutrition meal composition beneficial to medicine absorption and recovery and used for rehabilitation of osteopathic patients and medical nutrition meal Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a medical nutrition meal composition and a medical nutrition meal which are used together with a traditional Chinese medicine preparation for treating bone diseases and used for assisting in treating bone diseases, and particularly provides a medical nutrition meal composition which is beneficial to medicine absorption and recovery and is used for rehabilitation of bone disease patients, wherein the composition comprises the following substances in parts by weight: 20-30 parts of protein substances, 10-20 parts of fat substances, 4-50 parts of carbohydrate, 0.005 part of edible hyaluronic acid, 20.005 parts of vitamin K, 0.0001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride and 0.005 part of chondroitin sulfate; the medical nutrition meal composition can promote the absorption and utilization of the active ingredients of the traditional Chinese medicine preparation in the organism when being eaten in combination with the traditional Chinese medicine preparation, and the active ingredients in the medical nutrition meal can assist the treatment effect of bone diseases.
Description
Technical Field
The invention relates to the technical field of medical nutrition meals, in particular to a medical nutrition meal composition beneficial to medicine absorption and recovery for rehabilitation of osteopathic patients.
Background
The information in this background section is only for enhancement of understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art that is already known to a person of ordinary skill in the art.
Cervical spondylosis is a typical one of bone diseases, and the incidence rate of the cervical spondylosis is higher and higher due to the fact that modern people lean down to operate a mobile phone for a long time or work at desk for a long time, and the cervical spondylosis tends to be younger. Acute and chronic injuries of the cervical intervertebral disc can be caused by long-time improper working posture, poor sleeping position and unscientific physical exercise, and the degenerative change of the intervertebral disc is accelerated. Patients with cervical spondylosis often feel soreness and distension in the neck and shoulders, pain and discomfort, sensory and motor dysfunction of the limbs, and even seriously affect work and life.
The current methods for treatment of bone diseases are mainly surgical treatment and non-surgical treatment, and the non-surgical treatment methods include physical therapy, exercise therapy and drug therapy; most of the traditional Chinese medicines and western medicines in the pharmacotherapy have the effect of temporarily relieving pain, and the problem cannot be fundamentally solved; the Chinese medicinal preparation has unique curative effect on treating the bone diseases, can relieve and contact discomfort caused by the related bone diseases, can delay the progress of the disease development, and effectively prevent and control the relapse of the bone diseases. For example, the cervical pain granules for cervical spondylosis in the prior art can activate blood circulation to dissipate blood stasis, promote qi circulation to relieve pain, and can treat cervical spondylotic radiculopathy. However, the inventor finds that the traditional Chinese medicine preparation has the problems of low absorption rate and poor utilization rate after being taken by a patient with the bone disease due to the complexity of the components of the traditional Chinese medicine preparation and the unhealthy state of the body of the patient with the bone disease.
Disclosure of Invention
As discussed in the background art, when the traditional Chinese medicine preparation is used for treating bone diseases such as cervical spondylosis, the problems of low absorption rate and poor utilization rate are often existed. Based on the medical nutrition meal composition and the medical nutrition meal, the bone disease patient recovery medical nutrition meal beneficial to medicine absorption and recovery is provided, the patient can eat the traditional Chinese medicine preparation and eat the medical nutrition meal cooperatively, the absorption and utilization of the active ingredients of the traditional Chinese medicine preparation in the organism can be promoted, and the active ingredients in the medical nutrition meal can assist the treatment effect of the bone disease.
Specifically, the technical scheme of the invention is as follows:
in a first aspect of the invention, there is provided a medical nutritional meal composition for the rehabilitation of patients with bone diseases, which facilitates drug absorption and recovery, consisting of the following substances in parts by weight: 20-30 parts of protein substances, 10-20 parts of fat substances, 30-50 parts of carbohydrate, 0.005 part of hyaluronic acid, 20.005 parts of vitamin K, 0.0001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride and 0.005 part of chondroitin sulfate;
the protein substance is selected from one or more of the following: whey protein powder, casein, soybean short peptide, soybean protein isolate and collagen peptide;
the fatty substance is selected from one or more of the following: vegetable oils, fish oils, alpha-linolenic acid;
the carbohydrate is selected from one or more of the following: soybean oligosaccharide, fructo-oligosaccharide and maltodextrin.
In a second aspect of the present invention, there is provided a medical nutrition meal for facilitating the rehabilitation of a bone disease patient who is subject to drug absorption and recovery, which comprises the medical nutrition meal composition for facilitating the rehabilitation of a bone disease patient who is subject to drug absorption and recovery as described in the first aspect, and a preparation method of the medical nutrition meal for facilitating the rehabilitation of a bone disease patient who is subject to drug absorption and recovery, which comprises the steps of:
(1) weighing the raw materials according to the medical nutritional meal composition of the first aspect, and mixing powdery materials of protein substances, carbohydrate and calcium lactate to obtain powdery materials;
(2) adding oily material fatty substances into the powdery material obtained in the step (1) in a double-paddle trough type mixer, stirring for 3min, and uniformly mixing;
(3) sequentially adding edible hyaluronic acid, vitamin K2, vitamin D, D-glucosamine hydrochloride and chondroitin sulfate into the mixture obtained in the step (2), and uniformly stirring;
(4) and (4) performing mechanical pressing and forming and cutting on the mixture obtained in the step (3) to obtain the medical nutrition meal beneficial to medicine absorption and recovery for rehabilitation of osteopathic patients.
In a third aspect of the invention, the application of the medical nutrition meal which is beneficial to medicine absorption and recovery and is used for rehabilitation of patients with bone diseases in the second aspect in promoting absorption and utilization of traditional Chinese medicine preparations for treating cervical spondylosis and promoting rehabilitation of patients with cervical spondylosis is provided.
The specific embodiment of the invention has the following beneficial effects:
the medical nutrition meal provides various nutritional ingredients including protein substances, fat substances and carbohydrates, can meet the nutritional requirements of patients with cervical spondylosis, and does not generate redundant food residues; when the medical nutrition meal is used in combination with the traditional Chinese medicine preparation, the medical nutrition meal replaces conventional food, so that the influence of food residues in the gastrointestinal tract on medicine absorption can be reduced, and the absorption and utilization of effective components of the medicine can be promoted;
the edible hyaluronic acid is creatively added into the medical nutritional meal composition, and can play a role in lubricating joints and regulating the permeability of blood vessel walls through digestion and absorption, promote the absorption of effective components in the traditional Chinese medicine preparation by a bone disease patient and assist the recovery of bone diseases;
the D-glucosamine hydrochloride is matched with the chondroitin sulfate for use, has the effects of relieving pain and promoting cartilage regeneration, can fundamentally improve the problem of bone joints, and simultaneously supplements vitamin D and calcium, and the combination of the D-glucosamine hydrochloride and the chondroitin sulfate can achieve better effect of improving the joint symptoms of osteopathic patients;
vitamin K2 is the essential substance of human bone and calcium metabolism, plays key and decisive role in bone and calcium metabolism, and has protective effects on osteoblast, and vitamin K2 combines with calcium in the embodiment of the invention, promote the metabolism in the human body after calcium absorption, and play a role in protecting the joint so as to relieve the symptoms of bone diseases.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the invention and together with the description serve to explain the invention and not to limit the invention.
Fig. 1 is a graph showing the effect of the medical nutrition meal of the invention on promoting the absorption and utilization of the drug components in the cervicodynia granules of mice.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. The experimental procedures, in which specific conditions are not noted in the following examples, are generally carried out according to conventional conditions or according to conditions recommended by the manufacturers.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. The reagents or starting materials used in the present invention can be purchased from conventional sources, and unless otherwise specified, the reagents or starting materials used in the present invention can be used in a conventional manner in the art or in accordance with the product specifications. In addition, any methods and materials similar or equivalent to those described herein can be used in the methods of the present invention. The preferred embodiments and materials described herein are intended to be exemplary only.
As discussed in the background art, in the current treatment methods for cervical spondylosis, the traditional Chinese medicine preparation has unique curative effect on the treatment of cervical spondylosis, but due to the complexity of the components of the traditional Chinese medicine preparation and the unhealthy state of the body of a cervical spondylosis patient, the cervical spondylosis patient has the problems of low absorption rate and poor utilization rate after taking the traditional Chinese medicine preparation for treating cervical spondylosis.
Based on the medical nutrition meal composition and the medical nutrition meal, the medical nutrition meal composition and the medical nutrition meal are used together with a traditional Chinese medicine preparation for treating bone diseases for promoting the medicine absorption and recovery of bone disease patients.
In one embodiment of the invention, the medical nutrition meal composition for the rehabilitation of bone disease patients beneficial to drug absorption and recovery is provided and comprises the following substances in parts by weight: 20-30 parts of protein substances, 10-20 parts of fat substances, 30-50 parts of carbohydrate, 0.005 part of edible hyaluronic acid, 20.005 parts of vitamin K, 0.0001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride and 0.005 part of chondroitin sulfate;
the medical nutritional meal composition for bone disease patient rehabilitation, which is beneficial to drug absorption and recovery, provides various nutritional ingredients including protein substances, fat substances and carbohydrates, can meet the nutritional requirements of cervical spondylosis patients, and does not generate redundant food residues; when the medical nutrition meal composition is used together with a traditional Chinese medicine preparation, the medical nutrition meal replaces conventional food, the influence of food residues in the gastrointestinal tract on medicine absorption can be reduced, and the absorption and utilization of effective components of the medicine can be promoted.
The medical nutritional meal composition beneficial to medicine absorption and recovery for bone disease patient rehabilitation also comprises edible hyaluronic acid, wherein the hyaluronic acid is an acidic mucopolysaccharide, shows a plurality of important physiological functions in a body by virtue of a unique molecular structure and physical and chemical properties, and has high clinical value. The edible hyaluronic acid has the effects of lubricating joints and regulating the permeability of blood vessel walls through digestion and absorption, and can promote the absorption of effective components in the traditional Chinese medicine preparation by bone disease patients and also assist the rehabilitation of the joint problems of the bone disease patients.
Vitamin K2 is a fat-soluble vitamin and a key factor involved in blood coagulation, and epidemiological studies show that vitamin K2 deficiency may lead to osteoporosis and osteoarthritis; vitamin K2 plays a key and decisive role in bone and calcium metabolism, has a protective effect on osteoblasts, and vitamin K2 can promote osteoblast proliferation and osteoblast-osteoblast conversion in vitro; the invention combines vitamin K2 with calcium and vitamin D, promotes the metabolism of calcium absorbed in human body, and plays a role in protecting and assisting the recovery of osteopathic patients.
D-glucosamine hydrochloride is extracted from natural chitin, and has effects in promoting synthesis of mucopolysaccharide, increasing viscosity of synovial fluid, improving metabolism of articular cartilage, and treating bone joint diseases; chondroitin sulfate is a glycosaminoglycan that is covalently linked to proteins to form proteoglycans, and is widely distributed on the extracellular matrix and cell surface of animal tissues; d-glucosamine hydrochloride is matched with chondroitin sulfate for use, has the effects of relieving pain and promoting cartilage regeneration, and can fundamentally improve the joint problem; and simultaneously, the vitamin D and the calcium are supplemented, so that the symptoms of a patient with bone diseases can be better improved.
In a specific embodiment, the proteinaceous material is selected from one or more of the following: whey protein powder, casein, soybean short peptide, soybean protein isolate and collagen peptide;
the protein material contains high-quality protein, and can be used for bone disease patients to absorb and utilize protein to the maximum extent, and enhance immunity.
In a more specific embodiment, the proteinaceous material is a mixture of whey protein powder, casein and soy short peptides.
In a particular embodiment, the fatty substance is selected from one or more of the following: vegetable oil, fish oil, alpha-linolenic acid;
alpha-linolenic acid belongs to polyunsaturated fatty acid, is essential fatty acid of human body, and also constitutes an important component of brain cells and histiocytes of the human body, once the human body is lack of the alpha-linolenic acid, the lipid metabolism disorder of the human body can be caused, so that the symptoms of immunity reduction, fatigue and the like can be caused; the alpha-linolenic acid can improve the immunity of a patient with bone diseases, thereby improving the absorption of an organism to effective components of the traditional Chinese medicine preparation.
In a more specific embodiment, the fatty substance is a mixture of vegetable oil and alpha-linolenic acid.
In a particular embodiment, the carbohydrate is selected from one or more of the following: soybean oligosaccharide, fructo-oligosaccharide and maltodextrin.
In another embodiment of the invention, a medical nutrition meal beneficial to the rehabilitation of a bone disease patient with drug absorption and recovery is provided, which comprises the above medical nutrition meal composition beneficial to the rehabilitation of the bone disease patient with drug absorption and recovery, and the preparation method of the medical nutrition meal beneficial to the rehabilitation of the bone disease patient with drug absorption and recovery comprises the following steps:
(1) weighing the raw materials, and mixing powdery materials of protein substances, carbohydrate and calcium lactate to obtain powdery materials;
(2) adding oily material fatty substances into the powdery material obtained in the step (1) in a double-paddle trough type mixer, stirring for 3min, and uniformly mixing;
(3) sequentially adding edible hyaluronic acid, vitamin K2, vitamin D, D-glucosamine hydrochloride and chondroitin sulfate into the mixture obtained in the step (2), and uniformly stirring;
(4) and (4) performing mechanical pressing and forming and cutting on the mixture obtained in the step (3) to obtain the medical nutrition meal beneficial to medicine absorption and recovery for rehabilitation of osteopathic patients.
In another embodiment of the invention, the application of the medical nutrition meal beneficial to medicine absorption and recovery for bone disease patient rehabilitation in promoting the absorption and utilization of the traditional Chinese medicine preparation for treating bone disease and promoting the recovery of the bone disease patient is provided.
In order to make the technical solutions of the present invention more clearly understood by those skilled in the art, the technical solutions of the present invention will be described in detail below with reference to specific embodiments.
Example 1
A medical nutrition meal beneficial to medicine absorption and recovery for bone disease patient rehabilitation is composed of the following substances in parts by weight: 30 parts of protein substances (20 parts of whey protein powder, 5 parts of casein and 5 parts of soybean short peptide), 15 parts of fat substances (13 parts of vegetable oil and 2 parts of alpha-linolenic acid), 40 parts of carbohydrate (36 parts of maltodextrin, 2 parts of soybean oligosaccharide and 2 parts of fructo-oligosaccharide), 0.005 part of edible hyaluronic acid, 0. 20.005 part of vitamin K, 0.001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride and 0.005 part of chondroitin sulfate;
the preparation method of the medical nutrition meal beneficial to medicine absorption and recovery for rehabilitation of bone disease patients comprises the following steps:
(1) weighing the raw materials according to the composition, and mixing powdery materials of the protein substances, the carbohydrate and the calcium lactate to obtain powdery materials;
(2) adding oily material fatty substances into the powdery material obtained in the step (1) in a double-paddle trough type mixer, stirring for 3min, and uniformly mixing;
(3) sequentially adding edible hyaluronic acid, vitamin K2, vitamin D, D-glucosamine hydrochloride and chondroitin sulfate into the mixture obtained in the step (2), and uniformly stirring;
(4) and (4) performing mechanical pressing molding and cutting on the mixture obtained in the step (3) to obtain the medical nutrition meal.
Example 2
A medical nutrition meal beneficial to medicine absorption and recovery for bone disease patient rehabilitation is composed of the following substances in parts by weight: 25 parts of protein substances (15 parts of whey protein powder, 5 parts of casein and 5 parts of soybean short peptide), 20 parts of fat substances (17 parts of vegetable oil and 3 parts of alpha-linolenic acid), 40 parts of carbohydrate (36 parts of maltodextrin, 2 parts of soybean oligosaccharide and 2 parts of fructo-oligosaccharide), 0.005 part of edible hyaluronic acid, 20.005 parts of vitamin K, 0.0001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride and 0.005 part of chondroitin sulfate;
the preparation method of the medical nutrition meal beneficial to medicine absorption and recovery for rehabilitation of bone disease patients is the same as that in example 1.
Example 3
A medical nutrition meal beneficial to medicine absorption and recovery for bone disease patient rehabilitation is composed of the following substances in parts by weight: 30 parts of protein substances (20 parts of whey protein powder, 5 parts of casein and 5 parts of soybean protein isolate), 10 parts of fat substances (8 parts of vegetable oil and 2 parts of alpha-linolenic acid), 45 parts of carbohydrate (40 parts of maltodextrin, 2 parts of soybean oligosaccharide and 3 parts of fructo-oligosaccharide), 0.005 part of edible hyaluronic acid, 0. 20.005 part of vitamin K, 0.0001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride, 0.005 part of chondroitin sulfate and 2 parts of a traditional Chinese medicine composition;
the preparation method of the medical nutrition meal beneficial to medicine absorption and recovery for rehabilitation of bone disease patients is the same as that in example 1.
Comparative example 1
A medical nutrition meal beneficial to medicine absorption and recovery for bone disease patient rehabilitation is composed of the following substances in parts by weight: 30 parts of protein substances (20 parts of whey protein powder, 5 parts of casein and 5 parts of soybean short peptide), 15 parts of fat substances (13 parts of vegetable oil and 2 parts of alpha-linolenic acid), 40 parts of carbohydrate (36 parts of maltodextrin, 2 parts of soybean oligosaccharide and 2 parts of fructo-oligosaccharide), 0.0001 part of vitamin D and 6 parts of calcium lactate;
the preparation method of the medical nutrition meal beneficial to medicine absorption and recovery for rehabilitation of bone disease patients comprises the following steps:
(1) weighing the raw materials according to the composition, and mixing powdery materials of the protein substances, the carbohydrate and the calcium lactate to obtain powdery materials;
(2) adding oily material fatty substances into the powdery material obtained in the step (1) in a double-paddle trough type mixer, stirring for 3min, and uniformly mixing;
(3) adding food vitamin D into the mixture obtained in the step (2), and uniformly stirring;
(4) and (4) performing mechanical pressing molding and cutting on the mixture obtained in the step (3) to obtain the medical nutrition meal.
Comparative example 2
A medical nutrition meal beneficial to medicine absorption and recovery for bone disease patient rehabilitation is composed of the following substances in parts by weight: 30 parts of protein substances (20 parts of whey protein powder, 5 parts of casein and 5 parts of soybean short peptide), 15 parts of fat substances (13 parts of vegetable oil and 2 parts of alpha-linolenic acid), 40 parts of carbohydrate (36 parts of maltodextrin, 2 parts of soybean oligosaccharide and 2 parts of fructo-oligosaccharide), 0.005 part of edible hyaluronic acid, 20.005 parts of vitamin K, 0.0001 part of vitamin D and 6 parts of calcium lactate;
the preparation method of the medical nutrition meal beneficial to medicine absorption and recovery for rehabilitation of bone disease patients comprises the following steps:
(1) weighing the raw materials according to the composition, and mixing powdery materials of the protein substances, the carbohydrate and the calcium lactate to obtain powdery materials;
(2) adding oily material fatty substances into the powdery material obtained in the step (1) in a double-paddle trough type mixer, stirring for 3min, and uniformly mixing;
(3) sequentially adding edible hyaluronic acid, vitamin K2, vitamin D, D-glucosamine hydrochloride and chondroitin sulfate into the mixture obtained in the step (2), and uniformly stirring;
(4) and (4) performing mechanical pressing molding and cutting on the mixture obtained in the step (3) to obtain the medical nutrition meal.
Comparative example 3
A medical nutrition meal beneficial to medicine absorption and recovery for bone disease patient rehabilitation is composed of the following substances in parts by weight: 30 parts of protein substances (20 parts of whey protein powder, 5 parts of casein and 5 parts of soybean short peptide), 15 parts of fat substances (13 parts of vegetable oil and 2 parts of alpha-linolenic acid), 40 parts of carbohydrate (36 parts of maltodextrin, 2 parts of soybean oligosaccharide and 2 parts of fructo-oligosaccharide), 20.005 parts of vitamin K, 0.0001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride and 0.005 part of chondroitin sulfate;
the preparation method of the medical nutrition meal beneficial to medicine absorption and recovery for rehabilitation of bone disease patients comprises the following steps:
(1) weighing the raw materials according to the composition, and mixing powdery materials of the protein substances, the carbohydrate and the calcium lactate to obtain powdery materials;
(2) adding oily material fatty substances into the powdery material obtained in the step (1) in a double-paddle trough type mixer, stirring for 3min, and uniformly mixing;
(3) sequentially adding vitamin K2, vitamin D, D-glucosamine hydrochloride and chondroitin sulfate into the mixture obtained in the step (2), and uniformly stirring;
(4) and (4) performing mechanical pressing molding and cutting on the mixture obtained in the step (3) to obtain the medical nutrition meal.
Safety test
Taking 10 mice, and randomly dividing the mice into two groups, namely a control group and an experimental group; the mice in the control group were given physiological saline, the mice in the control group were given the medical nutrition meal of example 1, dissolved in warm water, and subjected to intragastric administration once a day in an intragastric administration manner at an intragastric administration dose of 2 g/kg. All mice were fed for 7 days in the same environment and the health status of both groups of mice was observed, including mental status, eating status and defecation status.
The mice in the experimental group are good in health condition and do not have any uncomfortable symptoms through feeding observation for 7 days.
Effect test
1. The intervention test of the medical nutrition meal beneficial to medicine absorption and recovery for rehabilitation of bone disease patients on mice comprises the following steps:
in the experiment, the traditional Chinese medicine preparation selects the neck pain granules, and the compositions of the neck pain granules known in the prior art are pseudo-ginseng, ligusticum wallichii, corydalis tuber, white paeony root, clematis chinensis, kudzu root and notopterygium root. According to the patent CN104887771A, the ginsenoside Rg1 is a typical component in the granules for relieving the neck pain, so the absorption and utilization conditions of the granules for relieving the neck pain are proved by detecting the ginsenoside Rg1 in the test.
Taking 150 mice, randomly dividing into 5 groups, feeding the cervicodynia granules to the mice in the group 1 in an intragastric manner, taking 20mg/kg of medicine dosage, taking venous blood of the mice according to the medicine taking time of 2, 4, 6, 8 and 10h, and detecting the content of ginsenoside Rg1 in the serum of the mice;
The detection result is shown in fig. 1, and the ordinate of fig. 1 is the content of ginsenoside Rg1, unit μ g/mL; as can be seen from the figure, the content of the ginsenoside Rg1 in the serum of the control group mouse is lowest, the content of the ginsenoside Rg1 in the serum of the group mouse in the example 1 is highest, and along with the metabolism of the drug in the blood, the content of the ginsenoside Rg1 in the serum of the group mouse in the example 1 is always higher than that of the control group mouse, which indicates that the medical nutrition meal prepared in the example 1 can effectively promote the absorption and utilization of the drug components in the cervicodynia granules by the mouse, so that the rehabilitation of cervical spondylosis can be promoted.
And the medical nutritional meal composition of the invention can help to relieve symptoms of patients with bone diseases due to the presence of the components of edible hyaluronic acid, vitamin K2, vitamin D, calcium lactate, D-glucosamine hydrochloride and chondroitin sulfate.
2. 26 patients with nerve root type cervical spondylosis who used the medical nutrition meal of the invention were followed up in the form of questionnaire, and the 26 patients all took the traditional Chinese medicine preparation for treating nerve root type cervical spondylosis. The follow-up results show that: 24 patients fed back that one of the breakfast, the lunch and the dinner is replaced by the medical nutrition meal every day, the medical nutrition meal is used consistently, the taste is good, the medical nutrition meal is considered to be effective from the sense, and the investigation result of other 2 patients is lost.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A medical nutritional meal composition for bone disease patient rehabilitation beneficial to drug absorption and recovery, characterized in that: the composition consists of the following substances in parts by weight: 20-30 parts of protein substances, 10-20 parts of fat substances, 30-50 parts of carbohydrate, 0.005 part of edible hyaluronic acid, 20.005 parts of vitamin K, 0.0001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride and 0.005 part of chondroitin sulfate.
2. The medical nutritional meal composition for bone disease patient rehabilitation for drug absorption and recovery as claimed in claim 1, wherein: the composition consists of the following substances in parts by weight: 25-30 parts of protein substances, 10-15 parts of fat substances, 35-50 parts of carbohydrate, 0.005 part of edible hyaluronic acid, 20.005 parts of vitamin K, 0.0001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride and 0.005 part of chondroitin sulfate.
3. The medical nutritional meal composition for bone disease patient rehabilitation for drug absorption and recovery as claimed in claim 1, wherein: the composition consists of the following substances in parts by weight: 20-20 parts of protein substances, 15-20 parts of fat substances, 30-45 parts of carbohydrate, 0.005 part of edible hyaluronic acid, 20.005 parts of vitamin K, 0.0001 part of vitamin D, 6 parts of calcium lactate, 0.005 part of D-glucosamine hydrochloride and 0.005 part of chondroitin sulfate.
4. The medical nutritional meal composition for bone disease patient rehabilitation for drug absorption and recovery as claimed in claim 1, wherein: the protein substance is selected from one or more of the following: whey protein powder, casein, soybean short peptide, soybean protein isolate and collagen peptide.
5. The medical nutritional meal composition for bone disease patient rehabilitation for drug absorption and recovery as claimed in claim 4, wherein: the protein substances are: whey protein powder, casein and soy protein isolate.
6. The medical nutritional meal composition for bone disease patient rehabilitation for drug absorption and recovery as claimed in claim 1, wherein: the fatty substance is selected from one or more of the following: vegetable oil, fish oil, alpha-linolenic acid; preferably vegetable oil and alpha-linolenic acid.
7. The medical nutritional meal composition for bone disease patient rehabilitation for drug absorption and recovery as claimed in claim 1, wherein: the fat substances are vegetable oil and alpha-linolenic acid.
8. The medical nutritional meal composition for bone disease patient rehabilitation for drug absorption and recovery as claimed in claim 1, wherein: the carbohydrate is selected from one or more of the following: soybean oligosaccharide, fructo-oligosaccharide and maltodextrin.
9. A medical nutrition meal for bone disease patient rehabilitation for drug absorption and recovery, comprising the ingredients as claimed in any one of claims 1 to 8, prepared by a method comprising the steps of:
(1) weighing the raw materials according to the composition, and mixing powdery materials of the protein substances, the carbohydrate, the calcium lactate and the traditional Chinese medicine composition to obtain powdery materials;
(2) adding oily material fatty substances into the powdery material obtained in the step (1) in a double-paddle trough type mixer, stirring for 3min, and uniformly mixing;
(3) sequentially adding edible hyaluronic acid, vitamin K2, vitamin D, D-glucosamine hydrochloride and chondroitin sulfate into the mixture obtained in the step (2), and uniformly stirring;
(4) and (4) performing mechanical pressing molding and cutting on the mixture obtained in the step (3) to obtain the medical nutrition meal.
10. The use of the medical nutrition meal for bone disease patient rehabilitation facilitating drug absorption and recovery as claimed in claim 9 for promoting absorption and utilization of Chinese herbal preparation for treating bone disease and promoting rehabilitation of bone disease patient.
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