CN101693108A - Oral nutrition composition for beautifying skin - Google Patents
Oral nutrition composition for beautifying skin Download PDFInfo
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- CN101693108A CN101693108A CN200910035871A CN200910035871A CN101693108A CN 101693108 A CN101693108 A CN 101693108A CN 200910035871 A CN200910035871 A CN 200910035871A CN 200910035871 A CN200910035871 A CN 200910035871A CN 101693108 A CN101693108 A CN 101693108A
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Abstract
The invention relates to an oral nutrition composition for beautifying skin, which contains collagen, hyaluronicacid and vitamin C, wherein the collagen is active small molecule peptide with the molecular weight of 2000-6000Dalton, the hyaluronicacid is sodium salt, zinc salt and kali salt, and the vitamin C is natural or synthesized. The invention overcomes the defects that the collagen can not be absorbed by a human body or hydrolyzed into amino acid because the molecular weight is too big, and most of the collagen loses the beautifying efficacy and the like. Hydroxyproline in collagen peptide is promoted to generate by using the vitamin C through active prolyl hydroxylases, the collagen forms big molecule collagen required by beautifying the skin by crosslinked with the hydroxyproline, the hyaluronicacid is also a better nutrient absorption promoting agent except for special water-holding function and is matched with the vitamin C and the collagen for use, which can achieve more ideal effect of promoting the hyaluronicacid to be absorbed.
Description
Technical field
The present invention relates to a kind of nutraceutical composition, particularly a kind of oral nutrition composition that is used for beautifying skin.
Background technology
Collagen protein is that human body is concluded the main component in the tissue, accounts for 1/3rd of body internal protein total amount.Collagen protein is skin, skeleton, tendon, the cartilage of human body, the constituent material of blood vessel, is rich in glycine, and proline and hydroxyproline are the main components of human body skin, account for skin dry weight 70%-80%.Dermal layer of the skin 75% is made up of collagen protein, and fibrous collagen protein forms network structure, and the tension force and the elasticity of skin is provided; Simultaneously, the collagen protein in the skin corium still is epidermal area and epidermis accessory organ's (hair) nutrition supply station, and is epidermis conveying moisture.Collagen protein sees easily that for the important function apparent hundred of skin the growth of skin, reparation and nutrition all be unable to do without collagen protein.Collagen protein makes cell become plentiful, thereby makes skin full, keeps skin elasticity with moist, and it is moist to keep skin.Skin health two big crucial crease-resistant with preserve moisture all relevant with collagen protein.
Hyaluronic acid is an indispensable material in cell division and the structure, the people embryo's period intravital hyaluronic acid contents the highest, be adult 20 times of tissue content, reduce gradually after the birth.If the intravital hyaluronic acid relative amount of 20 years old people is decided to be 100%, 30,50, drops to 65%, 45%, 25% respectively 60 years old the time.The contained hyaluronic amount of the crowd of same age is also different, and progeria patient's hyaluronic acid contents obviously reduces, and shows old and feeble many symptoms.
With advancing age, skin aging is that institute causes because collagen protein changes, and the change of collagen protein is owing to have due to the hyaluronic minimizing of water retention, the intravital hyaluronic acid of people is the process of a dynamic equilibrium, in normal human body, existing hyaluronic catabolic process, hyaluronic synthetic reaction is also arranged, with advancing age, hyaluronic acid contents will reduce gradually in the body, so the oral supplementation hyaluronic acid, for increasing ectogenic hyaluronic acid in the body, small intestinal is a topmost absorption organ in the human body, is synthesized hyaluronic acid again under the effect of synzyme in vivo again after hyaluronic acid is absorbed.Therefore, the function of keeping collagen protein just must be replenished hyaluronic acid.
From the nineties in 20th century oral collagen and hyaluronic cosmetics go on the market in Japan, through the checking of the market of more than ten years, show that it has certain activation Skin Cell, keeps epidermis moistening, improves the effect of skin function.
Before the present invention, nearest studies show that, the molecular weight of common collagen protein is too big, is approximately 300,000, usually can not be absorbed by the body; After high molecular collagen protein is eaten into belly, the human body endo enzyme can become aminoacid with most collagen hydrolysate, has just lost the effect of beauty treatment simultaneously, and fraction resolves into the short victory peptide chain of molecular weight, directly absorb in the blood, play the effect of beautifying skin.So after common collagen protein enters digestive system on the market, be digested and be common amino acid molecular, cosmetic result is had a greatly reduced quality, make beauty treatment consumer spend mint of money, but have to limited cosmetic result.
Summary of the invention
Purpose of the present invention just is to overcome above-mentioned defective, by collagen protein, hyaluronic acid and ascorbic combination, develops a kind of alimentation composition or health medicine that is used for beautifying skin.
Technical scheme of the present invention is:
The oral nutrition composition that is used for beautifying skin, its major technique are characterised in that and contain collagen protein, hyaluronic acid and vitamin C.
Its further technical scheme is:
Described collagen protein is that the molecular weight that obtains by biological enzyme digestion method from Corii Sus domestica, Corii Bovis seu Bubali, fish skin or fish scale is at 2000～6000 daltonian active small molecular polypeptide; Described hyaluronic acid is sodium salt, zinc salt and the potassium salt that obtains from animal tissue or bacterial fermentation; Described vitamin C is natural or synthetic, comprises its esters, as vitamin C calcium, sodium Vitamin C etc.
Further technical scheme is:
Can add in vitamin E and its esters, Semen Vitis viniferae extract, the isoflavone one or more.
Advantage of the present invention and effect are to adopt its molecular weight at 2000～6000 daltonian active collagen peptides, because of enzyme and the digestive enzyme in the intestines and stomach and similar that adopts, so can only be digested for the small-molecular weight collagen peptide of molecular weight about 2000 in limited degree during by digestive system and be entered blood circulation, be absorbed nourishing beauty skin after being transported to skin immediately.Add vitamin C and hyaluronic acid simultaneously, wherein vitamin C is an essential thing of making collagen protein, also be the porter of collagen peptide, thus overcome send out hypovitaminosis C make collagen protein synthesis generation obstacle and make that skin can produce that wrinkle, injured skin are difficult for restoring, blood vessel also can reduce because of the support of peripheral organization break hemorrhage, produce defective such as purpura.So vitamin C can promote the absorption of collagen protein with synthetic, and hyaluronic acid can make moisture enter intercellular substance, and form protein gel with protein bound, collagen protein in the skin and cell are sticked together, its principle is similar with the bonding brick of mortar, and hyaluronic acid can also promote the ascorbic absorption of nutrient substance.The three cooperates mutually; thereby the skin cell metabolism effect that combined effect is brought into normal play; play and keep cell moisture; the protection cell is not subjected to the infringement of pathogen; accelerate to recover skin histology, increase skin compactness and elasticity, reduce wrinkle and produce; eliminate skin problems such as cicatrix, freckle, black speck, senile plaque, crows-feet, shine skin vigor and brilliance again.
Experimentation proves, can be about 2000 by the molecular weight of the collagen protein of skin absorbs, too greatly can not be by skin absorbs, and too little then do not have a beauty functions.Absorption enters intravital collagen peptide, if there is not the ascorbic help of porter, also just can't arrive the skin corium of skin, and collagen protein just can better not inhaled by human body and absorb, and just can't reach the effect of beauty treatment yet.Absorption enters the collagen peptide and the vitamin C of skin corium, collagen peptide wherein is as the raw material supplying of making macromolecular collagen protein in the skin, vitamin C is then by the activation prolyl hydroxylase, promote the generation of the hydroxyproline in the collagen peptide, collagen peptide is crosslinked by hydroxyproline, forms the macromolecular collagen protein that beautifying skin needs; The hyaluronic acid that adds is except that having special water retention, and still good alimentation promoter is used with vitamin C and collagen protein, can reach the better effect that promotes its absorption.By three's coordinated, can repair injured skin histology rapidly, promote skin cell metabolism, increase the skin moisturizing ability, improve moistening effect, make skin more apparent beautiful; But also can adjust the skin oil and fat secretion, the protection skin can make coarse skin recover level and smooth, allows skin reply strong hydratability and tension force, promotes skin wound healing and surperficial self-sow, makes skin recover young vigor.
Among the present invention, except that collagen protein, hyaluronic acid and vitamin C, can also add Semen Vitis viniferae extract, vitamin E, isoflavone, because these three kinds of materials itself that add also have the function of antioxidation and beauty treatment, after collagen protein, hyaluronic acid and vitamin C cooperate, more can give full play to these several persons' synergism, reach than original better beautifying skin effect.
Wherein main active component procyanidin can promote collagen protein to form the crosslinked of appropriateness in the Semen Vitis viniferae extract, simultaneously as a kind of effective free radical scavenger, can prevent the generation of the unusual physiological situation of skin " excessively crosslinked ", thereby stoped the appearance of wrinkle of skin and vesicle, kept the submissive smooth of skin; And vitamin E has stronger beautifying skin and anti-radical action, can reduce the destruction of radical pair collagen protein, thereby improves collagen protein in the absorption by human body utilization; Isoflavone then by the effect of many approach performances such as antioxidation, inhibiting tyrosine protein kinase activity and estrogen-like effects anti aging effect, is regulated the skin fat metabolism, reduces athero, reaches the purpose of beautifying skin.
Other effect of the present invention will go on to say below.
Description of drawings
--test-meal group and matched group skin oil content, moisture content compare sketch map to Fig. 1 among-----embodiment 1.
The specific embodiment
Embodiment 1:
Get collagen protein 500mg, hyaluronic acid 200mg, vitamin C 500mg, mix homogeneously; The adjuvant that adding dosage form and mouthfeel needs can be made into oral liquid, capsule, tablet, granule, powder
Embodiment 2:
Get collagen protein 5000mg, hyaluronic acid 100mg, Catergen 50mg, mix homogeneously; The adjuvant that adding dosage form and mouthfeel needs can be made into oral liquid, capsule, tablet, granule, powder
Embodiment 3:
Get collagen protein 90mg, hyaluronic acid 10mg, vitamin C 10.5mg, vitamin E 3mg, Semen Vitis viniferae extract 15mg, isoflavone 6mg, mix homogeneously; The adjuvant that adding dosage form and mouthfeel needs can be made into oral liquid, capsule, tablet, granule, powder.
Embodiment 4:
Get collagen protein 90mg, hyaluronic acid 80mg, Catergen 0mg, vitamin E2 0mg, isoflavone 30mg, mix homogeneously; The adjuvant that adding dosage form and mouthfeel needs can be made into oral liquid, capsule, tablet, granule, powder.
Embodiment 5:
Get collagen protein 100mg, hyaluronic acid 50mg, vitamin C 50mg, vitamin E2 0mg, mix homogeneously; The adjuvant that adding dosage form and mouthfeel needs can be made into oral liquid, capsule, tablet, granule, powder.
Embodiment 6:
Get collagen protein 150mg, hyaluronic acid 30mg, vitamin C 50mg, Semen Vitis viniferae extract 15mg, mix homogeneously; The adjuvant that adding dosage form and mouthfeel needs can be made into oral liquid, capsule, tablet, granule, powder.Experimental results show that:
Test specimen: the formula ratio with embodiment 3 is made capsule as the product of experiment, the first test-meal group is only taken collagen protein and hyaluronic acid, the second test-meal group is taken collagen protein, hyaluronic acid and vitamin C, the 3rd food group is taken collagen protein, hyaluronic acid, vitamin C, vitamin E, Semen Vitis viniferae extract, isoflavone, and the 4th food group is taken with the 3rd group of the same product; Matched group is taken and form capsular adjuvant except that above raw material.
Experimenter group: the participation crowd is 22～50 years old health, the volunteer of office work, there are not any cardiovascular and cerebrovascular vessel, liver, kidney, hemopoietic system disease and psychiatric history, healthy, through comprising the whole body health inspection of indexs such as rabat, B ultrasonic, electrocardiogram, routine blood test, routine urinalysis, blood biochemistry, and carry out skin test, reject the high oil content skin person and moisture of skin＞12; Finally pick out male 44 people, women 56 people use table of random number, carry out the randomized controlled trial design, are divided into matched group and 3 groups of test-meal groups.Matched group 25 examples, male's 12 examples, women's 13 examples; The first test-meal group, 25 examples, male's 10 examples, women's 15 examples; The second test-meal group, 25 examples, male's 11 examples, women's 14 examples; The 3rd test-meal group 25 examples, male's 11 examples, women's 14 examples; There are no significant to learn check four groups of ages and sex difference by statistics, has comparability; The high oil content skin person of rejecting and the people of moisture of skin＞12 are formed the 4th test-meal group, 32 people.Experimenter's duration of test is not taken any relevant medicine, health food and is not made and applies some make up.
Test-meal method: every day 2 times, each 2, took continuously 30 days
Skin test: with skin moisture, oil content before and after the test-meal of skin analyzer test subject.
Test environment: spacious, ventilation condition is good, temperature, moisture stable.
Check point: under rest state, earlier dip in distilled water and clean forehead glabella position, measure moisture content, oil content after drying 15min with clean cotton balls.
Reference standard: according to the appended standard of Skin Analyzer SHP88 skin analyzer.
Oil content: 9～27 is normal,＜9 for low oil,＞27 be high oily;
Moisture content: 11～20 is normal,＜11 be hydropenia,＞20 be the moisture content abundance;
Criterion: be behind Instrument measuring effectively, moisture content or oil content improve, and check has apparent by statistics
Work property difference person; Invalidly be moisture content or the oil content person that do not significantly improve.
Assay: with the international SPSS10.0 of statistical software computational analysis data.Compare between group, the enumeration data chi-square criterion, measurement data is checked with t, and paired t-test is relatively used in front and back on the same group, as shown in Figure 1, can reach a conclusion:
1, the oil content of skin, moisture content four groups of mean comparison difference before test-meal do not have significance, the skin moisture difference of test-meal group has highly significant (P＜0.01) before and after the test-meal, the 1st group of test-meal and matched group difference have significance (P＜0.05), test-meal the 2nd, 3 groups with matched group difference highly significant (P＜0.01) is arranged, after the test-meal the 1st, 2, there was a significant difference for skin moisture between 3 groups (P＜0.05), the be significantly improved effect of skin moisture of product is described, the and the 1st, 2, the improvement effect strengthens gradually between 3 groups, collagen protein is described, hyaluronic acid, the 2nd group of effect of improving moisture of skin of vitamin C is better than collagen protein, hyaluronic the 1st group, increase Semen Vitis viniferae extract, the 3rd group of effect of improving moisture of skin of vitamin E and isoflavone significantly is better than collagen protein, hyaluronic acid, ascorbic the 2nd group.
2, own control compares, and changing difference before and after the oil content of matched group, the moisture content does not have significance, compares there was no significant difference with matched group before and after the oil content test-meal of the skin that test-meal is the 1st, 2,3 groups.The skin oil content difference of test-meal group 4 has highly significant (P＜0.01) before and after the test-meal, and skin moisture is there was no significant difference relatively, thereby the improvement effect of oil content is remarkable, and moisture content does not obviously improve.Test-meal group 4 is high oily skin, oil content is significantly improved before and after the test-meal, high oily skin is because the skin sebum secretion is many, corse sweat pore, easily give birth to acne and acne, influence beauty treatment, therefore the 4th group can be reduced the skin oil content by increasing Semen Vitis viniferae extract, vitamin E and isoflavone, reaches the purpose to high oily skin beauty treatment.
3, test-meal is after statistical test, test-meal group and matched group relatively, skin moisture is significant difference.The skin moisture that shows 1,2,3 groups of test-meals has clear improvement, and between group significant difference is arranged also, and increasing along with additive; the effect of protection moisture of skin is more remarkable, and is better for the cosmetic result of skin, because adequate moisture can reduce wrinkle; improve skin matter, beautify skin.
How many skin moisture and oil contents are the moist principal elements of decision skin smooth, and adequate moisture and suitable oil content can reduce wrinkle, improve skin matter.The continuous test-meal capsule of test-meal group 30 days, relatively reach with the blank group before and after its skin moisture self and relatively be significantly increased, show that this present invention has the remarkable efficacy that keeps skin moisture, and after increasing Semen Vitis viniferae extract, vitamin E and isoflavone, more remarkable effect, can also improve simultaneously the high oil content of skin, cosmetic result of the present invention is further improved.So the present invention has the activation Skin Cell simultaneously, keep epidermis moistening, improves the beauty functions of skin function.The test-meal group is edible observed after 30 days, did not see untoward reaction, and every health check-up and result of laboratory test are not seen yet has any infringement to human body, shows that product is without any toxicity.
Particularly:
Collagen protein, hyaluronic acid are the main components that constitutes skin and connective tissue, have significant water conservation, keep skin smooth and elastic effect.Along with people's age growth, collagen protein, hyaluronic content descend in the skin, gauffer occurs thereby molecular weight reduces skin.Collagen protein, hyaluronic acid by oral through digesting and assimilating, can increase collagen protein and the synthetic precursor substance of hyaluronic acid in the body, collagen protein and hyaluronic acid synthetic quantity in skin and its hetero-organization are increased, therefore, can repair the human body system that preserves moisture, firmly pin whole body moisture, increase the skin water content, the horny layer of softening skin improves the blood circulation and the metabolism of skin surface.Its beauty and health care functions is a general, be to increase endogenous collagen protein and hyaluronic content by corium to epidermis, the blood microcirculation amount is increased, cell activation, the performance general action, thereby the water retention property increase, high resilience, wrinkle of skin are reduced, belongs to endogenously, have significantly different with the use of cosmetics local topical.Therefore, keep the function of skin and just must replenish endogenous collagen protein and hyaluronic acid, and take vitamin C simultaneously, vitamin C can not only help the synthetic of collagen protein, and plays the part of porter's role in human body, makes the utilization that is absorbed by the body better of collagen protein and hyaluronic acid, the three is collaborative mutually, combined effect not only can reach better and beautify skin and make the glossy purpose of skin moisturizing, and also has effects such as strong skeleton, moulding, hair care, breast enlargement, fat-reducing.
More than research and experiment show, several raw material of the present invention all has unique effect to human body, cooperate each other and produce synergism, go deep into each cell and the tissue of human body skin, vitamin C wherein, vitamin E promotes absorbing of collagen protein, isoflavone prevents the loss of collagen protein by adjusting internal hormone excretory system and wears out, and collagen protein that absorbs and hyaluronic acid are intertwined to form network structure at connective tissue and elastin laminin and GL-PP, Semen Vitis viniferae extract further prevents collagen protein and hyaluronicly excessively interweaves, finally impel Skin Cell to produce certain mechanical strength and elasticity, the support body curve, embody tall and straight figure, really reach the optimum efficiency of whole skin beauty treatment.
The present invention can also keep vessel wall elasticity except that the beauty functions to skin, prevent angiorrhexis, thromboembolism; Improve the lubricated of joint, cartilage and ligament, alleviate ankylosis, ache, symptom such as hydrops; Promote the formation of new bone, strong skeleton, prevention and treatment osteoporosis; The source of also can be used as diabetes, nephropathy patient absorbing high-quality high protein; Health cares such as antiinflammatory, antiallergic, slow down aging.
The present invention is raw materials used can both to buy from the market, the active collagen peptide that used collagen protein raw material is produced by biological enzyme digestion method, and its molecular weight is 2000～6000; Used vitamin C and its esters be if natural, content requirement 〉=17%, if synthetic, content requirement 〉=20%; The effective ingredient of Semen Vitis viniferae extract is procyanidin (〉=80%); Isoflavone derives from Semen sojae atricolor or Radix Puerariae, and effective ingredient is the summation (〉=20%) of Genistin, genistein, daidzin, daidzein, Glycitein and Glycitein glycoside unit.
The claimed scope of the present invention is not limited only to the description of the foregoing description.
Claims (10)
1. the oral nutrition composition that is used for beautifying skin is characterized in that containing collagen protein, hyaluronic acid and vitamin C.
2. the oral nutrition composition that is used for beautifying skin according to claim 1 is characterized in that described collagen protein is that the molecular weight that obtains by biological enzyme digestion method is at 2000～6000 daltonian active small molecular polypeptide from Corii Sus domestica, Corii Bovis seu Bubali, fish skin or fish scale; Described hyaluronic acid is sodium salt, zinc salt and the potassium salt that obtains from animal tissue or bacterial fermentation; Described vitamin C is natural or synthetic, comprises its esters, as calcium salt, sodium salt.
3. the oral nutrition composition that is used for beautifying skin according to claim 1 is characterized in that the above unit dose scope is collagen protein 50～5000mg, hyaluronic acid 5～200mg, vitamin C 10～500mg
4. the oral nutrition composition that is used for beautifying skin according to claim 1 is characterized in that unit dose contains collagen protein 500mg, hyaluronic acid 200mg, vitamin C 500mg.
5. the oral nutrition composition that is used for beautifying skin according to claim 1 is characterized in that unit dose contains collagen protein 5000mg, hyaluronic acid 100mg, Catergen 50mg.
6. according to claim 1 or the 3 described oral nutrition compositions that are used for beautifying skin, it is characterized in that adding in vitamin E and its esters, Semen Vitis viniferae extract, the isoflavone one or more, the above unit dose scope is vitamin e1～150mg, Semen Vitis viniferae extract 15～500mg, isoflavone 5～150mg.。
7. according to claim 1 or the 3 described oral nutrition compositions that are used for beautifying skin, it is characterized in that unit dose is collagen protein 90mg, hyaluronic acid 10mg, vitamin C 10.5mg, vitamin E 3mg, Semen Vitis viniferae extract 15mg, isoflavone 6mg.
8. according to claim 1 or the 3 described oral nutrition compositions that are used for beautifying skin, it is characterized in that unit dose is collagen protein 90mg, hyaluronic acid 80m g, Catergen 0mg, vitamin E2 0mg, isoflavone 30mg.
9. according to claim 1 or the 3 described oral nutrition compositions that are used for beautifying skin, it is characterized in that unit dose contains collagen protein 100mg, hyaluronic acid 50mg, vitamin C 50mg, vitamin E2 0mg.
10. according to claim 1 or the 3 described oral nutrition compositions that are used for beautifying skin, it is characterized in that unit dose contains collagen protein 150mg, hyaluronic acid 30mg, vitamin C 50mg, Semen Vitis viniferae extract 15mg.
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