CN101554362A - Composition of natural product and preparation thereof - Google Patents
Composition of natural product and preparation thereof Download PDFInfo
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- CN101554362A CN101554362A CNA2008100109545A CN200810010954A CN101554362A CN 101554362 A CN101554362 A CN 101554362A CN A2008100109545 A CNA2008100109545 A CN A2008100109545A CN 200810010954 A CN200810010954 A CN 200810010954A CN 101554362 A CN101554362 A CN 101554362A
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- propolis
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- stichopus japonicus
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Abstract
The invention discloses a composition of a natural product, which is formed by combining sea cucumber and propolis. The sea cucumber refers to a whole body or a partage or/and enzymolysis product or/and extract of echinodermata, holothuroidea and sea cucumber; and the propolis refers to propolis in bee products. The composition can be used for preparing medicine, health-care products and various preparation forms of food; the preparation forms prepared by the composition comprise powder, pills, medicinal extracts, sublimed preparation, tablets, soft capsules, hard capsules, medicinal granules, suppository, oral liquid and injection; and the composition can be also used for preparing cosmetics and washing articles.
Description
[technical field]
The present invention relates to utilize Stichopus japonicus, comprise the prescription of the zymolyte of Stichopus japonicus powder, Stichopus japonicus extract, Stichopus japonicus and a kind of natural product that propolis makes up and the various preparations that prepare by this prescription.
[background technology]
The husky drop of Stichopus japonicus original name belongs to Echinodermata, is divided into beche-de-mer without spike and Radix Morinae Bulleyanae two big classes, and the whole world has about 1100 kinds, in state-owned about 120 kinds, the Stichopus japonicus that the whole world can be eaten has about 40 kinds, in kind surplus state-owned 20.
Propolis is the material that makes up Nidus Vespae, and its resin that to be Apis gather from plant plumule and trunk is sneaked into the colloid substance with aromatic odor that glandular secretion thing post-treatment such as palatine gland on the Apis, lingual gland, wax gland are transformed.The effect of propolis brilliance makes Nidus Vespae keep aseptic condition.
The Stichopus japonicus body contains protein, fat, carbohydrate, vitamin B
I, B
2, nutrient substance such as E, nicotinic acid PP, also contain acid mucopolysaccharide, holotoxin, chondroitin sulfate isoreactivity composition.HAICISHEN in the Stichopus japonicus (Stichopus Japonicus Selenka) is considered as helping the meals treasure since ancient times.The Ming Dynasty takes in book on Chinese herbal medicine later on.In the supplement to the Herbal of ZHAO Xue-Min, claim its " the kidney invigorating is through, beneficial marrow, the disease that disappears saliva, takes the photograph urine, and hemopoietic, tonifying YANG, treatment ulcer are given birth to cellulitis ".
Modern science and technology research confirms that Radix Morinae Bulleyanae mucopolysaccharide HG can resist the growth of kinds of tumors and transfer naturally.Regulate body's immunological function, improve the low situation of body's immunity that causes because of cancer therapy drug.Be applicable to put, patients undergoing chemotherapy, anticoagulation, reduce blood viscosity, suppress thrombosis.And have radioprotective, an anti-inflammatory properties.
The Radix Morinae Bulleyanae Saponin can effectively suppress growth of tumour cell, and the antagonism histiocyte is aging, has immunoloregulation function, anti-anemia, antifungal, radioprotective and fatigue.
Collagen protein in the Radix Morinae Bulleyanae, mineral and trace element, the health care of collaborative performance Stichopus japonicus.
And identified in the propolis that the natural materials that comes out reaches hundreds of, wherein flavone compound reaches kind more than 70, the micromolecule terpene substances reaches kind more than 50, phenols, alcohol compound kind more than 20, aldehyde and letones kind more than ten, kind surplus fatty acid and the fatty acid ester 50, the trace element of more than 30 kind of human body necessity and 20 several amino acids.Also have various saccharides, steroid class, enzyme, vitamin and other that organic compound of biologic activity is arranged.Kind surplus the trace element of needed by human reaches 30.As calcium, selenium, zinc, ferrum, manganese, copper, chromium, lithium, strontium, magnesium etc.
Studies show that in a large number propolis does not almost have toxic and side effects to human health effect mystery.
1, propolis is precious natural wide spectrum antibiotics.
Flavonoid, the terpenoid substance of the abundant uniqueness in the propolis have significant inhibition and killing action to various bacteria, fungus, virus etc.Can be used to treat the disease that pathogenic microorganisms such as beriberi, tinea unguium, eczema, various ulcer, periodontitis, rhinitis, urinary system infection, flu, hemorrhoid, diarrhoea cause, consumption is little, instant effect, do not destroy profitable strain, do not produce drug resistance.
2, propolis is precious immunostimulant, can significantly improve the resistance against diseases of health, and preventing cold, cancer, aging and elimination senile plaque, pigmentation are had good effect.
3, the effect of tangible blood sugar regulation and blood lipid regulation is arranged.
4, tangible preservation antioxidation effect is arranged.Flavonoid in the propolis and cinnamic acid derivative and vitamin E, C, A and trace element-selenium, zinc etc. all have certain antioxidation.These materials are fused to together cleverly by Apis, complement each other, and bring into play anti-oxidation function jointly.Take propolis for a long time, not only can activating cell, eliminate mottle, can also strong health, radiant, the youth is resident.
5, propolis has the tissue regeneration of promotion effect, the healing of accelerated in wounds.
6, have antitumor action, propolis and functional component have in the body, extracorporeal anti-tumor function, there are some researches show that propolis can directly suppress, kill cancerous cell, has excellent prevention and therapeutic effect to tumor, polyp.
7, control cardiovascular system diseases.Flavonoid substances content in the propolis is abundant, has effects such as good activating blood circulation to dissipate blood stasis, vessel softening, blood fat reducing, prevention platelet aggregation, microcirculation improvement.Sclerosis of blood vessels, infraction, thrombosis, hyperlipidemia etc. there are excellent prevention and therapeutic effect.
8, propolis significantly calm the nerves in addition, antiinflammatory, pain relieving, antipruritic, anesthesia, radiation resistance.
Can find out propolis evident in efficacy to hypertension, hyperlipidemia, middle-aged and elderly people is the often edible propolis of hypertension, hyperlipidemia, arteriosclerotic especially; Good health and a long life quite there is benifit.Propolis has stronger microcirculation improvement and anti-inflammatory properties.Diabetics visual deterioration and skin infection there are tangible curative effect, and can strengthen the system of diabetes, alleviate the symptom of " three-many-one-little ".
By on can state, can see prophylactic treatment aspect to some major disease, HAICISHEN and propolis are perfectly in harmony, as antiinflammatory, antitumor, hyperlipidemia, hypertension etc.
[summary of the invention]
So, use HAICISHEN, bee-glue composition than take HAICISHEN separately, the propolis effect how?
The inventor once did the test of mycete aspect.
1, the HAICISHEN body is got the preparation of thing
Fresh and alive HAICISHEN 1000g gets except that gonad and intestinal tube, cleans, rubs, puts into immediately the boiling water that 1500ml boils, and constantly stirs and boils, slow fire is little to boil, and to 30-40 minute, crocus cloth filtered, get the about 1000ml of filtrate, cool, add 5 times of amount acetone, get suspension, placement is spent the night, next day centrifugal collecting precipitation, acetone flavor is waved diffusing, the HAICISHEN body be got thing 28g.
2, the source of propolis
Buy the diffusing propolis 25g of Beijing Apis hall
3, take by weighing HAICISHEN extract 15g as supplying reagent I
Take by weighing propolis 15g as supplying reagent II
After taking by weighing HAICISHEN extract 7.5g and propolis 7.5g mix homogeneously, as supplying reagent III
4, I, II described in (3), III supply reagent respectively to add dimethyl Asia (30%) through fully stirring, each get sample I, II, the III that is for external application and tests for three kinds.
5, tinea corporis patient 30 people are selected in external antifungal test, and per ten people are one group, and every group of state of an illness is more or less the same, and are first, second, the third three groups, and the A group is used the HAICISHEN extract, and the B group is used propolis, and the C group is used HAICISHEN extract and bee-glue composition.
30 selected people all are diagnosed as the patient of tinea for clinical and microscopy, wipe affected part 3-4 time with this product every day, and per three weeks are a course of treatment, and the 1st, 2,3 weeks were respectively got the specimen microscopy once after the medication.
The course of treatment, evaluation criteria was divided into three grades
Recovery from illness: subjective symptoms disappears, deflorescence, negative fungal examination.
Effectively: subjective symptoms and erythra obviously disappear, the negative fungal examination or the positive.
Invalid: subjective symptoms and erythra do not have improvement, the fungus microscope examination positive.
Efficacy result sees Table I
| Group | Amount to routine number | Recovery from illness | Effectively | Invalid |
| I | 10 | 5 | 2 | 3 |
| II | 10 | 3 | 1 | 6 |
| III | 10 | 7 | 2 | 1 |
As seen from the table, the effective percentage that takes by weighing the complex capsule of HAICISHEN extract and propolis is 90%, far above 70% of 40% and HAICISHEN extract of propolis group, may be the coefficient result of flavonoid, terpenes and holotoxin in the propolis.The treatment of three weeks finishes, and supply to try to such an extent that three samples just use up, and to be coated with dose roughly the same at every turn.
The inventor also once did the compositions of HAICISHEN extract and propolis and did the drop test that ancillary drug is worked in coordination with potassium alginate depressor, and potassium alginate is national antihypertensive drugs.
1, the experimenter is volunteer participant, counts 60 examples, test-meal group male 16 examples, women's 14 examples, minimum 40 years old of age, maximum 70 years old, 57.5 years old mean age, matched group male 15 examples, women's 15 examples, minimum 38 years old of age, maximum 71 years old, 56.2 years old mean age.Mean blood pressure before the test, test-meal group: systolic pressure 148.76 ± 13.25 (mmHg), diastolic pressure 96.35 ± 8.92 (mmHg); Matched group: systolic pressure 149.25 ± 12.91 (mmHg), diastolic pressure 97.78 ± 9.25 (mmHg).
Before the visible test of above-mentioned situation, test-meal group and matched group nature situation be every compares no significant difference, has comparability.
2, test-meal group is taken potassium alginate 6 grams every day, respectively 3 restrains sooner or later, and adds 4 of HAICISHEN propolis complex capsules, every 0.4 gram, HAICISHEN extract and propolis half and half.Matched group is taken potassium alginate 6 grams every day, respectively 3 restrains sooner or later.
3,30 days test periods, measured blood pressure once in per 10 days, three times mean blood pressure is as the blood pressure after treating.
4, systolic pressure and diastolic pressure change
Table 1, systolic pressure change relatively
| Group | Before the test (mmHg) | Test back (mmHg) | Difference (mmHg) |
| The test-meal group | 149.25±12.91 | 110.36±11.65## | 39.09±12.31 |
| Matched group | 148.76±13.25 | 128.28±10.23 *## | 20.48±10.23 |
Contrast ##P＜0.01 between own control * P＜0.01 group
Table 2, diastolic pressure change relatively
| Group | Before the test (mmHg) | Test back (mmHg) | Difference (mmHg) |
| The test-meal group | 96.35±8.92 | 81.95±10.25## | 14.40±13.25 |
| Matched group | 97.78±9.25 | 89.26±11.37 *## | 8.52±12.65 |
Contrast P＜0.01 between own control * P＜0.01 group
Conclusion: from the variation of systolic pressure and diastolic pressure; the test-meal group that adds the HAICISHEN bee glue capsule has significant difference than potassium alginate treatment matched group; Flavonoid substances is arranged in the propolis; and containing materials such as taurine, chondroitin sulfate, acid mucopolysaccharide in the HAICISHEN, these materials all have the auxiliary treatment effect to hyperlipidemia, hypertension etc.Therefore the test-meal group that adds HAICISHEN extract and propolis has remarkable hypotensive effect to systolic pressure and diastolic pressure than matched group.
Commercially available beche-de-mer capsules, bee glue capsule all is the single capsule basically at present, but a lot of consumers all are that difference is all eaten, this both made troubles to consumer, increased consumption to consumer again, zymolyte and the propolis of Stichopus japonicus extract or Stichopus japonicus powder or Stichopus japonicus are combined into a kind of group of thing, so both reduced the level of consumption of consumer, brought convenience to consumer again.
The inventor is grouped together Stichopus japonicus powder and propolis, forms a kind of new prescription, in this prescription, can also contain other food, medicine composition.
A kind of prescription that contains Stichopus japonicus powder and propolis, wherein the content of Stichopus japonicus powder is 10
-2PPM-99.9999%, the content of propolis are 99.9999%-10
-2PPM
More than said Stichopus japonicus powder comprise that the extract of the ground product of Stichopus japonicus, the enzymatic hydrolysate of Stichopus japonicus or Stichopus japonicus also can be two or three mixture in the middle of above-mentioned three kinds, propolis is meant the propolis in the middle of the bee product.
This prescription can prepare hard capsule, soft capsule, powder, pill, unguentum, sublimed preparation, tablet, electuary, suppository, oral liquid, injection.These preparations can be as medicine, health food and food.
[specific embodiment]
1, HAICISHEN bee glue soft capsule
Prescription:
HAICISHEN extract 30g
Propolis 24g
Olive oil is an amount of
Gelatin is an amount of
The method preparation gets 270 soft capsules routinely, and every contains 0.2g HAICISHEN propolis mixture, every day the 4-6 grain.
2, HAICISHEN propolis hard capsule
Prescription:
HAICISHEN lyophilized powder 15g
Propolis 15g
The method preparation gets 90 hard capsules routinely, and every contains 0.3g, every day the 3-5 grain.
3, HAICISHEN propolis ointment
Prescription:
HAICISHEN zymolyte 10g
Propolis 10g
Vaseline paste 250g
Through fully grind externally-applied ointment.Effect: protection skin, beauty treatment, sun-proof.
Claims (4)
1, a kind of prescription of natural product, in this prescription, the ratio of Stichopus japonicus and prescription (weight ratio) is 10
-2PPM-99.9999%, the ratio of propolis and prescription (weight ratio) is 99.9999%-10
-2PPM.
2, the Stichopus japonicus of claim 1 indication be meant whole or its partage of Echinodermata (echinoderm) Holothuroidea animal Stichopus japonicus ground product (and/or) it enzymatic hydrolysate (and/or) extract.It can solid-state form exist, and also can suspension exist, and also can exist by solution state.Propolis then is meant the propolis in the bee product.
3, the claimed prescription of claim 1, the dosage form of various medicines, health product and the food of preparation.Comprise powder, pill, unguentum, sublimed preparation, tablet, hard capsule, soft capsule, electuary, suppository, oral liquid, injection.
4, the cosmetics and the cleaning product of the preparation of the claimed prescription of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100109545A CN101554362A (en) | 2008-04-09 | 2008-04-09 | Composition of natural product and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100109545A CN101554362A (en) | 2008-04-09 | 2008-04-09 | Composition of natural product and preparation thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101554362A true CN101554362A (en) | 2009-10-14 |
Family
ID=41172744
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|---|---|---|---|
| CNA2008100109545A Pending CN101554362A (en) | 2008-04-09 | 2008-04-09 | Composition of natural product and preparation thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406112A (en) * | 2011-11-30 | 2012-04-11 | 山东大学 | Nourishing health-care buccal tablet |
| CN102813198A (en) * | 2012-08-31 | 2012-12-12 | 威海五谷怡健食品有限公司 | Functional food for preventing hyperlipidemia, hyperglycemia and hypertension of middle aged and elderly people and preparation method thereof |
| CN104666223A (en) * | 2015-01-26 | 2015-06-03 | 山东中医药高等专科学校 | Face-beautifying and skin-caring cream |
| CN104872485A (en) * | 2015-04-30 | 2015-09-02 | 青岛金谷原生命科技有限公司 | Preparation method of tablets containing sea cucumber, cordyceps sinensis and propolis |
| CN105560325A (en) * | 2015-12-31 | 2016-05-11 | 李秋 | Foamed emulsion for protecting skin of foot of diabetes patients and preparation method thereof |
| CN111543638A (en) * | 2020-06-30 | 2020-08-18 | 江南大学 | Sea cucumber polysaccharide product with auxiliary blood sugar reducing effect and preparation method thereof |
| CN111658669A (en) * | 2020-06-19 | 2020-09-15 | 北京本真工坊生物科技有限公司 | External application composition and application thereof |
-
2008
- 2008-04-09 CN CNA2008100109545A patent/CN101554362A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406112A (en) * | 2011-11-30 | 2012-04-11 | 山东大学 | Nourishing health-care buccal tablet |
| CN102813198A (en) * | 2012-08-31 | 2012-12-12 | 威海五谷怡健食品有限公司 | Functional food for preventing hyperlipidemia, hyperglycemia and hypertension of middle aged and elderly people and preparation method thereof |
| CN104666223A (en) * | 2015-01-26 | 2015-06-03 | 山东中医药高等专科学校 | Face-beautifying and skin-caring cream |
| CN104872485A (en) * | 2015-04-30 | 2015-09-02 | 青岛金谷原生命科技有限公司 | Preparation method of tablets containing sea cucumber, cordyceps sinensis and propolis |
| CN104872485B (en) * | 2015-04-30 | 2018-04-13 | 青岛大学 | A kind of preparation method of sea cucumber cordyceps sinensis propolis piece |
| CN105560325A (en) * | 2015-12-31 | 2016-05-11 | 李秋 | Foamed emulsion for protecting skin of foot of diabetes patients and preparation method thereof |
| CN111658669A (en) * | 2020-06-19 | 2020-09-15 | 北京本真工坊生物科技有限公司 | External application composition and application thereof |
| CN111543638A (en) * | 2020-06-30 | 2020-08-18 | 江南大学 | Sea cucumber polysaccharide product with auxiliary blood sugar reducing effect and preparation method thereof |
| CN111543638B (en) * | 2020-06-30 | 2023-12-12 | 江南大学 | Sea cucumber polysaccharide product with auxiliary blood sugar reducing effect and preparation method thereof |
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Application publication date: 20091014 |