CN103610112A - Immunity-enhancing sea cucumber oral liquid and application method thereof - Google Patents

Immunity-enhancing sea cucumber oral liquid and application method thereof Download PDF

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Publication number
CN103610112A
CN103610112A CN201310490940.9A CN201310490940A CN103610112A CN 103610112 A CN103610112 A CN 103610112A CN 201310490940 A CN201310490940 A CN 201310490940A CN 103610112 A CN103610112 A CN 103610112A
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sea cucumber
oral liquid
immunity
parts
enhancing
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姜玉宝
耿元生
杨惠云
张晓龙
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QINGDAO JIAREILONG SEA FOOD CO Ltd
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QINGDAO JIAREILONG SEA FOOD CO Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30Dietetic or nutritional methods, e.g. for losing weight
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

A provided immunity-enhancing sea cucumber oral liquid comprises the following active components: polyghaceseche, matrimony vine, laminaria japonica, bear gall, radix bupleuri, salvia miltiorrhiza, rhizoma polygonati, perilla seeds, cattail pollen, semen astragali complanati, coriolus versicolor, rhizome polygoni cuspidate, polygonum aviculare, andrographis paniculata nees and sea cucumber. The application method of the sea cucumber oral liquid comprises that adults take 5 mL of the oral liquid respectively at the morning and at the evening, calcium gluconate is taken when the elderly take the oral liquid, and vitamin C pulvis is taken when children take the oral liquid. The immunity-enhancing sea cucumber oral liquid is simple in ratio and reasonable in formula matching, and is capable of adjusting human body function, reducing blood pressure well, reducing blood sugar well, reducing blood fat well, and enhancing human body immunity.

Description

A kind of holothurian oral liquid and using method thereof that strengthens immunity
 
technical field:
The present invention relates to sea cucumber deep process technology field, relate in particular to a kind of holothurian oral liquid and using method thereof that strengthens immunity.
 
background technology:
Modern scientific research proves, sea cucumber nutrient is worth very high, in every hectogram, contain 15 grams, protein, 1 gram, fat, 0.4 gram, carbohydrate, 357 milligrams of calcium, 12 milligrams, phosphorus, 2.4 milligrams of iron, and vitamin B1, B2, more than the 50 kind of nutritional labeling useful to human physiological activity such as niacin, wherein protein content is up to more than 55%, it contains 18 seed amino acid taurines, chondroitin sulfate, stichopus japonicus mucopolysaccharide Multiple components, arginine is the main component that forms male sex's spermatid, it is again the primary raw material of synthesized human collagen, reparation after can promoting the regeneration of body cell and body impaired, can also improve the immunologic function of human body, promote longevity, eliminate tired.
Sea cucumber is extremely low containing cholesterol, is a kind of typical high protein, low fat, low cholesterol food.Add its fine and tender taste, be easy to digestion, so, be suitable for very much the elderly, children and the people that has a delicate constitution edible.Sea cucumber, because of extremely low containing cholesterol, is the food of a kind of typical high protein, low fat, low cholesterol.Because of fine and tender taste, be easy to digestion again, thus be applicable to very much the elderly and children, and the person of having a delicate constitution is edible.Taurine in sea cucumber, niacin etc.; there is the nervous system of adjusting, elimination fatigue fast; the effect of prevention skin aging; the taurine containing in sea cucumber in addition, lysine, methionine etc. almost do not have in vegetable food; the chondroitin sulfate containing in stichopus japonicus and stichopus japonicus mucopolysaccharide; by pharmacological evaluation, prove, to the growing of human body, anti-inflammatory skeletonization and prevention failure, promoting wound healing to suppress several cancer cells has special efficacy.Continuity is old and feeble, eliminate tired, improve immunity, the ability sea cucumber that strengthens resist the disease is rich in the natural precious active materials of kind more than 50 such as protein, mineral matter, vitamin, wherein acid mucopolysaccharide and chondroitin can obviously reduce the quantity of lipofuscin and skin proline in heart tissue, play the effect delaying senility.In sea cucumber body, 18 contained seed amino acids can strengthen the metabolic function of tissue, and enhanced machine body cell vigor, is suitable for the teenager in growing.Sea cucumber energy balance the body water balance, is suitable for the Ms of pregnancy period legs and feet edema.Sea cucumber can be eliminated tired, improves body immunity, strengthens the ability of human body resist the disease, is therefore applicable to very much often middle aged Ms and the man in fatigue state, the sub-health populations such as easy catching a cold, the elderly who has a delicate constitution and children.
Sea cucumber is not only delicious food, and is good tonic.Taurine in sea cucumber, lysine etc. almost do not have in vegetable food.The distinctive active material holothurin of sea cucumber, has significant inhibitory action to multiple fungi, has significant anti-inflammatory, osteogenic action, especially hepatitis, tuberculosis, diabetes, cardiovascular disease is had significant therapeutic effect.In brain healthy, practise midwifery lactagogue stichopus japonicus, contain two kinds of omega-3-polyunsaturated fatty acids (EPA and DHA).Wherein DHA plays vital effect to fetal brain cell development.Human brain is grown and is started from pregnant three month, and fetus obtains DHA and EPA from parent by placenta.If parent lacks DHA, can cause the Phospholipids of fetal brain cell not enough, affect the normal development of fetal central nervous system.DHA has significant benifit to strengthening memory and IQ, but also can make pregnant and lying-in women's breast enlargement, and milk is full.
Other functions of sea cucumber, as eliminated tumour, the anticancer heart that protects: contain a large amount of holothurins in the tissues such as body wall, internal organ and body of gland of sea cucumber, be again Sea Cucumber Glycosides.Holothurin is a kind of counterpoison, nontoxic to human-body safety, but growth and the transfer of energy inhibition tumor cell, effectively anti-cancer, anticancer, has been widely used in the treatment of liver cancer, lung cancer, cancer of the stomach, nasopharyngeal carcinoma, osteocarcinoma, lymph cancer, oophoroma, the cancer of the uterus, breast cancer, cancer of the brain leukaemia and hand postoperative patient clinically.Improve the frequent beche-de-mer of osteoporosis and can prevent children's rickets, adult's osteoporosis and hyperostosis.In gold most distinguished sea cucumber, the element such as abundant calcium, phosphorus, manganese, copper, germanium, silicon is to prevention Infant Rickets, adult's osteoporosis and to skeletal abnormality, deformity, and dentine and enamel development be bad special role.Enhancing development beche-de-mer helps lend some impetus to and grows.Abundant arginine, lysine, taurine, calcium, phosphorus, iodine, iron, zinc in sea cucumber; it is the important substance that human development grows up; they participate in the physiological activities such as the growing of human body itself, immune regulation, wound healing, reproductive development directly, in body energy deposit and running, play an important role.
Sea cucumber as in Chinese medicine simply, widely recorded, as, < < new compilation of materia medica > >: tonifying kidney and benefiting sperm, impotence is treated in establishing-Yang.The < < property of medicine is examined > >: fall fiery nourshing kidney, logical intestines are moisturized, except the timid disease of labor.< < food compatibility and incompatibility of drugs > >: kidney tonifying warp, beneficial marrow, dissolving phlegm saliva, takes the photograph urine, and impotence is treated in establishing-Yang, kills sore worm.The < < detailed outline > > that picks up any lost article from the road: raw hundred arteries and veins blood, control recurrent dysentery.< < book on Chinese herbal medicine is asked former > >: moisturizing viscera, grow smart Li Shui.< < occupies diet spectrum > > with breath: enriching yin, to enrich blood, and strong sun, moisturizes, menstruation regulating, nourishing the fetus, profit is produced.All postpartum,, should simmer food with ham or pig mutton.The modern Practical Chinese medicinal > of < < > nature and flavor: cold nature, taste is sweet, salty.Return lung, kidney, large intestine channel.Tonifying kidney and benefiting sperm; Enriching the blood to restore normal menstruation; Hemostasis.Cure mainly: essence and blood loss; Weak labor is timid; Impotence; Nocturnal emission; The dry constipation of intestines; Cough due to deficiency of the lung's spitting of blood, hematochezia, traumatism and bleeding.
Sea cucumber contains outside protein, calcium, potassium, zinc, iron, selenium, manganese isoreactivity material, and other active component is by holothurin and by amidohexose, uronic acid and fucose etc. form Stichopus Japonicus Acidic Mucopolysaccharide, separately containing 18 seed amino acids and do not contain cholesterol in sea cucumber body.Because sea cucumber is warm in nature, there is the strong sun of tonifying kidney and benefiting sperm, enriching yin, nourishing blood for moistening dryness, the menstruation regulating tonifying both YIN and YANG effects such as labor, nourishing the fetus profit product of dispelling.Can improve male endocrine ability, improve women's metabolism, promote sex hormone secretion ability, improve sexual function.From traditional Chinese medical science angle, kidney is basis of human body, as long as kidney goes wrong, be not only the problem that life quality reduces, and other organs can corresponding exhaustion.And palace product sea cucumber is to the main reinforcing kidney and strengthening resistance of the effect of human body, the element culturing fixed folder of namely as the saying goes.As long as human kidney is strong, each organ channels and collaterals all can be corresponding strong, and final people knows from experience more healthy, and the ability of resist the disease strengthens greatly.
The instructions of taking of sea cucumber, still take tonic as main at present, and tonic causes human absorptivity not enough, and the taboo of some culinary arts also usually causes the loss of sea cucumber nutrient composition, as, sea cucumber can not be cooked flavouring with vinegar.Therefore, there are on the market some sea cucumber deep processed products, as oral liquid, tablet, capsule, honey refining pill etc., in the process of deep processing, often adds Chinese patent drug to improve the absorptivity of product or to increase other auxiliary functions, but, some formula is unreasonable, for example, sea cucumber can not with Radix Glycyrrhizae compatibility etc.Therefore, it is simple that the present invention aims to provide a kind of proportioning, and prescription collocation is reasonable, balance the body function, and hypotensive, hypoglycemic, lipid-lowering effect is good, strengthens a kind of holothurian oral liquid and using method thereof that strengthens immunity of body immunity.
 
summary of the invention:
The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of proportioning simple, prescription collocation rationally, balance the body function, hypotensive, hypoglycemic, lipid-lowering effect is good, strengthens a kind of holothurian oral liquid and using method thereof that strengthens immunity of body immunity.
To achieve these goals, the invention provides a kind of holothurian oral liquid that strengthens immunity, wherein, comprise following active component: radix polygonati officinalis, matrimony vine, kelp, bear gall, radix bupleuri, the red sage root, sealwort, perillaseed, cattail pollen, semen astragali complanati, rainbow conk, giant knotweed , pivot holds, Herba Andrographitis, sea cucumber.
The using method of the holothurian oral liquid of described enhancing immunity, comprises the steps:
Per day for adults is respectively taken 5ml sooner or later,
When taking, the elderly adds calcium gluconae,
When taking, child adds vitamin C pulvis.
Strengthen the holothurian oral liquid of immunity, wherein, comprise according to the following active component of parts by weight configuration:
Radix polygonati officinalis 30-50 part, matrimony vine 20-40 part, kelp 20-40 part, bear gall 20-40 part, radix bupleuri 10-30 part, red sage root 10-30 part, sealwort 10-30 part, perillaseed 10-30 part, cattail pollen 10-30 part, semen astragali complanati 10-30 part, rainbow conk 10-30 part, giant knotweed 10-30 Fen , pivot holds 10-30 part, Herba Andrographitis 10-30 part, sea cucumber 300-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Radix polygonati officinalis 30-40 part, matrimony vine 20-30 part, kelp 20-30 part, bear gall 20-30 part, radix bupleuri 10-20 part, red sage root 10-20 part, sealwort 10-20 part, perillaseed 10-20 part, cattail pollen 10-20 part, semen astragali complanati 10-20 part, rainbow conk 10-20 part, giant knotweed 10-20 Fen , pivot holds 10-20 part, Herba Andrographitis 10-20 part, sea cucumber 300-400 part.
Or, comprise according to the following active component of parts by weight configuration:
Radix polygonati officinalis 40-50 part, matrimony vine 30-40 part, kelp 30-40 part, bear gall 30-40 part, radix bupleuri 20-30 part, red sage root 20-30 part, sealwort 20-30 part, perillaseed 20-30 part, cattail pollen 20-30 part, semen astragali complanati 20-30 part, rainbow conk 20-30 part, giant knotweed 20-30 Fen , pivot holds 20-30 part, Herba Andrographitis 20-30 part, sea cucumber 400-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Radix polygonati officinalis 35-45 part, matrimony vine 25-35 part, kelp 25-35 part, bear gall 25-35 part, radix bupleuri 15-25 part, red sage root 15-25 part, sealwort 15-25 part, perillaseed 15-25 part, cattail pollen 15-25 part, semen astragali complanati 15-25 part, rainbow conk 15-25 part, giant knotweed 15-25 Fen , pivot holds 15-25 part, Herba Andrographitis 15-25 part, sea cucumber 350-450 part.
Object to better implement the present invention, the present invention discloses again a kind of preparation method who strengthens the holothurian oral liquid of immunity, wherein, comprises the steps:
The step of A, cleaning: by radix polygonati officinalis, matrimony vine, kelp, bear gall, radix bupleuri, the red sage root, sealwort, perillaseed, cattail pollen, semen astragali complanati, rainbow conk, giant knotweed pivot holds, and Herba Andrographitis, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
 
Advantage of the present invention is: proportioning is simple, and prescription collocation is reasonable, balance the body function, and hypotensive, hypoglycemic, lipid-lowering effect is good, strengthens body immunity, is specially:
In sea cucumber extract, mix traditional Chinese medicine liquid and formed oral liquid of the present invention, oral liquid have taking dose little, absorb the advantages such as very fast, steady quality, easy to carry and use, easy preservation, be especially applicable to suitability for industrialized production.The present invention is to hypotensive, reducing blood lipid, and blood sugar decreasing effect is remarkable, can significantly improve body immunity, and by independent beche-de-mer or take more separately herb liquid, effect is all significantly increased.
the specific embodiment:
Strengthen a holothurian oral liquid for immunity, wherein, comprise following active component: radix polygonati officinalis, matrimony vine, kelp, bear gall, radix bupleuri, the red sage root, sealwort, perillaseed, cattail pollen, semen astragali complanati, rainbow conk, giant knotweed , pivot holds, Herba Andrographitis, sea cucumber.
The using method of the holothurian oral liquid of described enhancing immunity, comprises the steps:
Per day for adults is respectively taken 5ml sooner or later,
When taking, the elderly adds calcium gluconae,
When taking, child adds vitamin C pulvis.
The holothurian oral liquid of enhancing immunity of the present invention, wherein, comprises according to the following active component of parts by weight configuration:
Radix polygonati officinalis 30-50 part, matrimony vine 20-40 part, kelp 20-40 part, bear gall 20-40 part, radix bupleuri 10-30 part, red sage root 10-30 part, sealwort 10-30 part, perillaseed 10-30 part, cattail pollen 10-30 part, semen astragali complanati 10-30 part, rainbow conk 10-30 part, giant knotweed 10-30 Fen , pivot holds 10-30 part, Herba Andrographitis 10-30 part, sea cucumber 300-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Radix polygonati officinalis 30-40 part, matrimony vine 20-30 part, kelp 20-30 part, bear gall 20-30 part, radix bupleuri 10-20 part, red sage root 10-20 part, sealwort 10-20 part, perillaseed 10-20 part, cattail pollen 10-20 part, semen astragali complanati 10-20 part, rainbow conk 10-20 part, giant knotweed 10-20 Fen , pivot holds 10-20 part, Herba Andrographitis 10-20 part, sea cucumber 300-400 part.
Or, comprise according to the following active component of parts by weight configuration:
Radix polygonati officinalis 40-50 part, matrimony vine 30-40 part, kelp 30-40 part, bear gall 30-40 part, radix bupleuri 20-30 part, red sage root 20-30 part, sealwort 20-30 part, perillaseed 20-30 part, cattail pollen 20-30 part, semen astragali complanati 20-30 part, rainbow conk 20-30 part, giant knotweed 20-30 Fen , pivot holds 20-30 part, Herba Andrographitis 20-30 part, sea cucumber 400-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Radix polygonati officinalis 35-45 part, matrimony vine 25-35 part, kelp 25-35 part, bear gall 25-35 part, radix bupleuri 15-25 part, red sage root 15-25 part, sealwort 15-25 part, perillaseed 15-25 part, cattail pollen 15-25 part, semen astragali complanati 15-25 part, rainbow conk 15-25 part, giant knotweed 15-25 Fen , pivot holds 15-25 part, Herba Andrographitis 15-25 part, sea cucumber 350-450 part.
Object to better implement the present invention, the present invention discloses again a kind of preparation method who strengthens the holothurian oral liquid of immunity, wherein, comprises the steps:
The step of A, cleaning: by radix polygonati officinalis, matrimony vine, kelp, bear gall, radix bupleuri, the red sage root, sealwort, perillaseed, cattail pollen, semen astragali complanati, rainbow conk, giant knotweed pivot holds, and Herba Andrographitis, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
 
Object lesson 1
50 parts of radix polygonati officinalis, 40 parts of matrimony vines, 40 parts of kelps, 40 parts of bear galls, 30 parts of radix bupleuri, 30 parts of the reds sage root, 30 parts of sealworts, 30 parts of perillaseeds, 30 parts of cattail pollens, 30 parts of semen astragali complanatis, 30 parts of rainbow conk, giant knotweed 30 Fen , pivots hold 30 parts, 30 parts of Herba Andrographitis, 500 parts of sea cucumbers.
The step of A, cleaning: by radix polygonati officinalis, matrimony vine, kelp, bear gall, radix bupleuri, the red sage root, sealwort, perillaseed, cattail pollen, semen astragali complanati, rainbow conk, giant knotweed pivot holds, and Herba Andrographitis, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
 
Example 2
30 parts of radix polygonati officinalis, 20 parts of matrimony vines, 20 parts of kelps, 20 parts of bear galls, 10 parts of radix bupleuri, 10 parts of the reds sage root, 10 parts of sealworts, 10 parts of perillaseeds, 10 parts of cattail pollens, 10 parts of semen astragali complanatis, 10 parts of rainbow conk, giant knotweed 10 Fen , pivots hold 10 parts, 10 parts of Herba Andrographitis, 300 parts of sea cucumbers.
The step of A, cleaning: by radix polygonati officinalis, matrimony vine, kelp, bear gall, radix bupleuri, the red sage root, sealwort, perillaseed, cattail pollen, semen astragali complanati, rainbow conk, giant knotweed pivot holds, and Herba Andrographitis, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
 
Example 3
40 parts of radix polygonati officinalis, 30 parts of matrimony vines, 30 parts of kelps, 30 parts of bear galls, 20 parts of radix bupleuri, 20 parts of the reds sage root, 20 parts of sealworts, 20 parts of perillaseeds, 20 parts of cattail pollens, 20 parts of semen astragali complanatis, 20 parts of rainbow conk, giant knotweed 20 Fen , pivots hold 20 parts, 20 parts of Herba Andrographitis, 400 parts of sea cucumbers.
The step of A, cleaning: by radix polygonati officinalis, matrimony vine, kelp, bear gall, radix bupleuri, the red sage root, sealwort, perillaseed, cattail pollen, semen astragali complanati, rainbow conk, giant knotweed pivot holds, and Herba Andrographitis, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
 
Data comparison:
By step e gained traditional Chinese medicine liquid, three high crowd 50 people take, as A group,
By step F gained sea cucumber extract, three high crowd 50 people take, as B group
Three high crowd 50 people take the holothurian oral liquid that traditional tradition strengthens immunity, and for example " the disclosed oral liquid of patent application 201210420808.6 " as C group,
Three high crowd's 50 people's beche-de-mers, one for each person every day, as D group.
Embodiment 1 takes for three high crowd 50 people, as E group.
Embodiment 2 takes for three high crowd 50 people, as F group.
Embodiment 3 takes for three high crowd 50 people, as G group.
Take continuously after 50 days, each one body status data is as follows: (people's health index mainly comprises the indexes such as body temperature, blood pressure, blood sugar, blood viscosity, blood fat, heart rate, and normal person's index is:
Body temperature, adult's body temperature temperature is 36.5-37 degree (oxter).
Blood pressure, adult's blood pressure should be systolic pressure 90-140 mercury column, diastolic pressure 60-90 mercury column.
Blood sugar, fasting blood-glucose normal value is below 6.1 or 109 milligrams, the normal value of blood sugar is below 7.8 or 140 milligrams after meal.
Blood viscosity is the abbreviation of blood viscosity, it is one of index of reflection viscosity of blood, the factor that affects blood viscousness mainly contains erythrocyte aggregation and morphotropism, packed cell volume, size and geometric, Blood Cholesterol, triglycerides and fibrinogenic content etc.
Blood fat, the lipid material in blood plasma is called blood fat, comprises triglycerides, phosphatide, cholesterol, cholesteryl ester and non-esterified fatty acid etc.
Heart rate, about 60-80 time of general adult's heartbeat per minute, average out to 75 times, children's heart rate is very fast.Pulse, is grown up 60-70 time per minute.Breathe the breathing per minute 14-18 time of being grown up)
Immunity comparison
Select the holothurian oral liquid of 10 small white mouse feeding tradition enhancing immunity as a control group,
Select 10 small white mouse feedings the present invention group as a comparison.
Be compared as follows:
Wherein, the absorption of comparative group calcium and mineral matter is fast, and propagation Bifidobacterium, lactic acid bacteria number is many, and the index of blood fat, blood sugar, adjusting cholesterol is low compared with control group.3-5 is placed in dark environment and the environment that is exposed to the sun repeatedly in day, the control group probability of catching an illness is large, so comparative group immunity is strong.
 
So advantage of the present invention is: proportioning is simple, prescription collocation is reasonable, balance the body function, and hypotensive, hypoglycemic, lipid-lowering effect is good, strengthens body immunity, is specially:
In sea cucumber extract, mix traditional Chinese medicine liquid and formed oral liquid of the present invention, oral liquid have taking dose little, absorb the advantages such as very fast, steady quality, easy to carry and use, easy preservation, be especially applicable to suitability for industrialized production.The present invention is to hypotensive, reducing blood lipid, and blood sugar decreasing effect is remarkable, can significantly improve body immunity, and by independent beche-de-mer or take more separately herb liquid, effect is all significantly increased.

Claims (2)

1. a holothurian oral liquid that strengthens immunity, is characterized in that, comprises following active component: radix polygonati officinalis, and matrimony vine, kelp, bear gall, radix bupleuri, the red sage root, sealwort, perillaseed, cattail pollen, semen astragali complanati, rainbow conk, giant knotweed, pivot holds, Herba Andrographitis, sea cucumber.
2. strengthen as claimed in claim 1 a using method for the holothurian oral liquid of immunity, it is characterized in that, comprise the steps:
Per day for adults is respectively taken 5ml sooner or later,
When taking, the elderly adds calcium gluconae,
When taking, child adds vitamin C pulvis.
CN201310490940.9A 2013-10-20 2013-10-20 Immunity-enhancing sea cucumber oral liquid and application method thereof Pending CN103610112A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104643144A (en) * 2015-03-23 2015-05-27 万雄集团股份有限公司 Sea cucumber traditional Chinese medicine decoction for improving male sexual disfunction and preparation method of sea cucumber traditional Chinese medicine decoction
CN111820386A (en) * 2020-06-24 2020-10-27 青岛越群生物科技有限公司 Sea cucumber oral liquid and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104643144A (en) * 2015-03-23 2015-05-27 万雄集团股份有限公司 Sea cucumber traditional Chinese medicine decoction for improving male sexual disfunction and preparation method of sea cucumber traditional Chinese medicine decoction
CN111820386A (en) * 2020-06-24 2020-10-27 青岛越群生物科技有限公司 Sea cucumber oral liquid and preparation method thereof

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