CN103610998A - Sea cucumber nutritional capsule - Google Patents

Abstract

A provided sea cucumber nutritional capsule comprises the following active components in parts by weight: 30-50 parts of eucommia, 20-40 parts of radix paeoniae alba, 20-40 parts of semen cuscutae, 20-40 parts of sesame, 10-30 parts of chestnut, 10-30 parts of Chinese yam, 10-30 parts of walnut, 10-30 parts of longan, 10-30 parts of radix codonopsis, 10-30 parts of coix seeds, 10-30 parts of rhaponticum uniflorm, 10-30 parts of rhizoma polygoni cuspidate, 10-30 parts of radix astragali, 10-30 parts of glutinous rehmannia and 300-500 parts of sea cucumber. The sea cucumber nutritional capsule is simple in ratio and reasonable in formula matching, and is capable of tonifying kidney, enriching essence, nourishing yin, fortifying yang, tonifying blood, moistening dryness, regulating menstruation, dispelling fatigue and improving human body immunity.

Description

A kind of sea cucumber nutrient capsule

  

technical field:

The present invention relates to Stichopus japonicus deep process technology field, relate in particular to a kind of sea cucumber nutrient capsule.

  

background technology:

Modern scientific research proves, sea cucumber nutrient is worth very high, in every hectogram, contain 15 grams, protein, 1 gram, fat, 0.4 gram of carbohydrate, 357 milligrams of calcium, 12 milligrams, phosphorus, 2.4 milligrams of ferrum, and vitamin B1, B2, more than the 50 kind of nutritional labeling useful to human physiological activity such as nicotinic acid, wherein protein content is up to more than 55%, it contains 18 seed amino acid taurines, chondroitin sulfate, Radix Morinae Bulleyanae mucopolysaccharide Multiple components, arginine is the main component that forms male's spermatid, it is again the primary raw material of synthesized human collagen protein, reparation after can promoting the regeneration of body cell and body impaired, can also improve the immunologic function of human body, life lengthening, allaying tiredness.

Stichopus japonicus is extremely low containing cholesterol, is a kind of typical high protein, low fat, low cholesterol food.Add its fine and tender taste, be easy to digestion, so, be suitable for very much old people, child and the people that has a delicate constitution edible.Stichopus japonicus, because of extremely low containing cholesterol, is the food of a kind of typical high protein, low fat, low cholesterol.Because of fine and tender taste, be easy to digestion again, thus be applicable to very much old people and child, and the person of having a delicate constitution is edible.Taurine in Stichopus japonicus, nicotinic acid etc.; there is nervous system regulation, quick allaying tiredness; the effect of prevention skin aging; the taurine containing in Stichopus japonicus in addition, lysine, methionine etc. almost do not have in vegetable food; the chondroitin sulfate containing in Radix Morinae Bulleyanae and Radix Morinae Bulleyanae mucopolysaccharide; by pharmacological evaluation, prove, to the growth promoter of human body, antiinflammatory skeletonization and prevention failure, promoting wound healing to suppress several cancerous cell has special efficacy.Continuity is old and feeble, allaying tiredness, improve immunity, the natural precious active substances of kind more than 50 such as the ability Stichopus japonicus rich in proteins of enhancing resist the disease, mineral, vitamin, wherein acid mucopolysaccharide and chrondroitin can obviously reduce the quantity of lipofuscin and skin proline in heart tissue, play the effect of slow down aging.In Stichopus japonicus body, 18 contained seed amino acids can strengthen the metabolic function of tissue, and enhancing body cell viability, is suitable for the teenager in growth promoter.Stichopus japonicus energy balance the body water balance, is suitable for the Ms of pregnancy period legs and feet edema.Stichopus japonicus energy allaying tiredness, improves body immunity, strengthens the ability of human body resist the disease, is therefore applicable to very much often middle aged Ms and the man in fatigue state, the sub-health populations such as easy catching a cold, the old people who has a delicate constitution and child.

Stichopus japonicus is not only delicious food, and is good tonic.Taurine in Stichopus japonicus, lysine etc. almost do not have in vegetable food.The distinctive active substance holothurin of Stichopus japonicus, has significant inhibitory action to multiple fungus, has significant antiinflammatory, ossification, especially hepatitis, tuberculosis, diabetes, cardiovascular diseases is had significant therapeutic effect.In brain healthy, practise midwifery lactogenic Radix Morinae Bulleyanae, contain two kinds of omega-3-polyunsaturated fatty acids (EPA and DHA).Wherein DHA plays vital effect to fetal brain cell development.Human brain is grown and is started from pregnant three month, and fetus obtains DHA and EPA from parent by Placenta Hominis.If parent lacks DHA, can cause the phospholipid of fetal brain cell not enough, affect the normal development of fetal central nervous system.DHA has significant benifit to memory reinforcing and IQ, but also can make pregnant and lying-in women's breast enlargement, and milk is full.

Other functions of Stichopus japonicus, as eliminated tumor, the anticancer heart that protects: contain a large amount of holothurins in the tissues such as body wall, internal organs and body of gland of Stichopus japonicus, be again holotoxin.Holothurin is a kind of counterpoison, nontoxic to human-body safety, but growth and the transfer of energy inhibition tumor cell, effectively anti-cancer, anticancer, has been widely used in the treatment of hepatocarcinoma, pulmonary carcinoma, gastric cancer, nasopharyngeal carcinoma, osteocarcinoma, lymphatic cancer, ovarian cancer, uterus carcinoma, breast carcinoma, brain cancer leukemia and hands postoperative patient clinically.Improve the frequent beche-de-mer of osteoporosis and can prevent child's rickets, adult's osteoporosis and bone matrix hyperplasia.In gold most distinguished Stichopus japonicus, the element such as abundant calcium, phosphorus, manganese, copper, germanium, silicon is to prevention Infant Rickets, adult's osteoporosis and to skeletal abnormality, deformity, and dentine and enamel development be bad special role.Enhancing development beche-de-mer helps lend some impetus to growth promoter.Abundant arginine, lysine, taurine, calcium, phosphorus, iodine, ferrum, zinc in Stichopus japonicus; it is the important substance that human development grows up; they participate in the physiological activities such as growth promoter, immune regulation, wound healing, reproductive development of human body itself directly, in body energy deposit and running, play an important role.

Stichopus japonicus as in Chinese medicine simply, widely recorded, as, < < Bencao Congxin > >: the kidney invigorating and essence nourishing, flaccidity is treated in tonifying YANG.The < < property of medicine is examined > >: pathogenic fire reducing nourishing kidney, logical intestinal is moisturized, except the timid disease of labor.< < food compatibility and incompatibility of drugs > >: the kidney invigorating warp, beneficial marrow, expectorant saliva, takes the photograph urine, and flaccidity is treated in tonifying YANG, kills skin ulcer worm.The < < detailed outline > > that picks up any lost article from the road: raw hundred arteries and veins blood, control chronic dysentery with frequent relapse.< < book on Chinese herbal medicine is asked former > >: moistening five ZANG-organs, grow smart diuretic.< < occupies diet spectrum > > with breath: YIN nourishing, to enrich blood, and strong sun, moisturizes, regulating menstruation, fetus nourishing, profit is produced.All puerperal,, should simmer food with Petaso or pig Carnis caprae seu ovis.The modern Practical Chinese medicinal > of < < > nature and flavor: cold nature, sweet in the mouth, salty.Return lung, kidney, large intestine channel.The kidney invigorating and essence nourishing; Blood enriching and dryness moistening; Hemostasis.Cure mainly: essence and blood loss; Weak labor is timid; Sexual impotence; Nocturnal emission; Dryness of the intestine constipation; Cough due to deficiency of the lung's spitting of blood, discharging fresh blood stool, traumatic hemorrhage.

Stichopus japonicus contains outside protein, calcium, potassium, zinc, ferrum, selenium, manganese isoreactivity material, and other active component is by holothurin and by amidohexose, alduronic acid and fucose etc. form Stichopus Japonicus Acidic Mucopolysaccharide, separately containing 18 seed amino acids and do not contain cholesterol in Stichopus japonicus body.Because Stichopus japonicus is warm in nature, there is the strong sun of the kidney invigorating and essence nourishing, YIN nourishing, nourishing blood for moistening dryness, the regulating menstruation tonifying both YIN and YANG effects such as labor, fetus nourishing profit product of dispelling.Can improve male endocrine ability, improve women's metabolism, promote sex hormones secretion ability, improve sexual function.From traditional Chinese medical science angle, kidney is basis of human body, as long as kidney goes wrong, be not only the problem that life quality reduces, and other organs can corresponding exhaustion.And Stichopus japonicus is to the main reinforcing kidney and strengthening resistance of the effect of human body, the element culturing fixed folder of namely as the saying goes.As long as human kidney is strong, each organ meridians all can be corresponding strong, and final people knows from experience more healthy, and the ability of resist the disease strengthens greatly.

The instructions of taking of Stichopus japonicus, still take tonic as main at present, and tonic causes human absorptivity not enough, and the taboo of some culinary arts also usually causes the loss of sea cucumber nutrient composition, as, Stichopus japonicus can not be cooked flavoring agent with vinegar.Therefore, there are on the market some Stichopus japonicus deep processed products, as oral liquid, tablet, capsule, honey refining pill etc., in the process of deep processing, often adds Chinese patent medicine to improve the absorbance of product or to increase other auxiliary functions, but, some formula is unreasonable, for example, Stichopus japonicus can not with Radix Glycyrrhizae compatibility etc.Therefore, it is simple that the present invention aims to provide a kind of proportioning, prescription collocation rationally, the kidney invigorating and essence nourishing, the strong sun of YIN nourishing, nourishing blood for moistening dryness, regulating menstruation dispel labor, improve a kind of sea cucumber nutrient capsule of body immunity.

  

summary of the invention:

The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of proportioning simple, prescription collocation rationally, the kidney invigorating and essence nourishing, the strong sun of YIN nourishing, nourishing blood for moistening dryness, regulating menstruation dispel labor, improve a kind of sea cucumber nutrient capsule of body immunity.

To achieve these goals, the invention provides a kind of sea cucumber nutrient capsule, wherein, comprise according to the following active component of parts by weight configuration:

Cortex Eucommiae 30-50 part, Radix Paeoniae Alba 20-40 part, Semen Cuscutae 20-40 part, Semen Sesami 20-40 part, Semen Castaneae 10-30 part, Rhizoma Dioscoreae 10-30 part, Semen Juglandis 10-30 part, Arillus Longan 10-30 part, Radix Codonopsis 10-30 part, Semen Coicis 10-30 part, Radix Rhapontici 10-30 part, Rhizoma Polygoni Cuspidati 10-30 part, Radix Astragali 10-30 part, Radix Rehmanniae 10-30 part, Stichopus japonicus 300-500 part.

Or, comprise according to the following active component of parts by weight configuration:

Cortex Eucommiae 30-40 part, Radix Paeoniae Alba 20-30 part, Semen Cuscutae 20-30 part, Semen Sesami 20-30 part, Semen Castaneae 10-20 part, Rhizoma Dioscoreae 10-20 part, Semen Juglandis 10-20 part, Arillus Longan 10-20 part, Radix Codonopsis 10-20 part, Semen Coicis 10-20 part, Radix Rhapontici 10-20 part, Rhizoma Polygoni Cuspidati 10-20 part, Radix Astragali 10-20 part, Radix Rehmanniae 10-20 part, Stichopus japonicus 300-400 part.

Or, comprise according to the following active component of parts by weight configuration:

Cortex Eucommiae 40-50 part, Radix Paeoniae Alba 30-40 part, Semen Cuscutae 30-40 part, Semen Sesami 30-40 part, Semen Castaneae 20-30 part, Rhizoma Dioscoreae 20-30 part, Semen Juglandis 20-30 part, Arillus Longan 20-30 part, Radix Codonopsis 20-30 part, Semen Coicis 20-30 part, Radix Rhapontici 20-30 part, Rhizoma Polygoni Cuspidati 20-30 part, Radix Astragali 20-30 part, Radix Rehmanniae 20-30 part, Stichopus japonicus 400-500 part.

Or, comprise according to the following active component of parts by weight configuration:

Cortex Eucommiae 35-45 part, Radix Paeoniae Alba 25-35 part, Semen Cuscutae 25-35 part, Semen Sesami 25-35 part, Semen Castaneae 15-25 part, Rhizoma Dioscoreae 15-25 part, Semen Juglandis 15-25 part, Arillus Longan 15-25 part, Radix Codonopsis 15-25 part, Semen Coicis 15-25 part, Radix Rhapontici 15-25 part, Rhizoma Polygoni Cuspidati 15-25 part, Radix Astragali 15-25 part, Radix Rehmanniae 15-25 part, Stichopus japonicus 350-450 part.

Object to better implement the present invention, the invention also discloses the preparation method of sea cucumber nutrient capsule, wherein, comprises the steps:

The step of A, cleaning: by the Cortex Eucommiae, the Radix Paeoniae Alba, Semen Cuscutae, Semen Sesami, Semen Castaneae, Rhizoma Dioscoreae, Semen Juglandis, Arillus Longan, Radix Codonopsis, Semen Coicis, Radix Rhapontici, Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Rehmanniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 3-5 minute, avoids drug effect to run off;

The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;

C, above-mentioned component add 10 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;

The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;

In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,

E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mix homogeneously, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicated powder, then medicated powder is incapsulated according to every capsule 5-8g.

  

Advantage of the present invention is: proportioning is simple, prescription collocation rationally, the kidney invigorating and essence nourishing, the strong sun of YIN nourishing, nourishing blood for moistening dryness, regulating menstruation dispel labor, improve body immunity.Be specially:

The present invention adds Chinese medicine powder on the basis of sea cucumber extract, after fully dissolving, again the sea cucumber extract preparation that is dissolved with Chinese medicine powder is become to dry extract, after dry, obtain medicated powder, medicated powder obtains the present invention after capsule subpackage, Chinese prescription the kidney invigorating and essence nourishing of the present invention, the strong sun of YIN nourishing, and, pass through kidney channel, (traditional Chinese medical science thinks that liver not directly mends for spleen channel and then nourishing the liver, one mends and to get angry, and spleen reinforcing, the kidney invigorating get final product nourishing the liver) in kidney tonifying nourishing YIN and supplementing blood not, add the medicine that appropriateness is taken good care of liver, total tune internal organs environment, increases immunity.

the specific embodiment:

Sea cucumber nutrient capsule, wherein, comprises according to the following active component of parts by weight configuration:

Cortex Eucommiae 30-50 part, Radix Paeoniae Alba 20-40 part, Semen Cuscutae 20-40 part, Semen Sesami 20-40 part, Semen Castaneae 10-30 part, Rhizoma Dioscoreae 10-30 part, Semen Juglandis 10-30 part, Arillus Longan 10-30 part, Radix Codonopsis 10-30 part, Semen Coicis 10-30 part, Radix Rhapontici 10-30 part, Rhizoma Polygoni Cuspidati 10-30 part, Radix Astragali 10-30 part, Radix Rehmanniae 10-30 part, Stichopus japonicus 300-500 part.

Or, comprise according to the following active component of parts by weight configuration:

Cortex Eucommiae 30-40 part, Radix Paeoniae Alba 20-30 part, Semen Cuscutae 20-30 part, Semen Sesami 20-30 part, Semen Castaneae 10-20 part, Rhizoma Dioscoreae 10-20 part, Semen Juglandis 10-20 part, Arillus Longan 10-20 part, Radix Codonopsis 10-20 part, Semen Coicis 10-20 part, Radix Rhapontici 10-20 part, Rhizoma Polygoni Cuspidati 10-20 part, Radix Astragali 10-20 part, Radix Rehmanniae 10-20 part, Stichopus japonicus 300-400 part.

Or, comprise according to the following active component of parts by weight configuration:

Cortex Eucommiae 40-50 part, Radix Paeoniae Alba 30-40 part, Semen Cuscutae 30-40 part, Semen Sesami 30-40 part, Semen Castaneae 20-30 part, Rhizoma Dioscoreae 20-30 part, Semen Juglandis 20-30 part, Arillus Longan 20-30 part, Radix Codonopsis 20-30 part, Semen Coicis 20-30 part, Radix Rhapontici 20-30 part, Rhizoma Polygoni Cuspidati 20-30 part, Radix Astragali 20-30 part, Radix Rehmanniae 20-30 part, Stichopus japonicus 400-500 part.

Or, comprise according to the following active component of parts by weight configuration:

Cortex Eucommiae 35-45 part, Radix Paeoniae Alba 25-35 part, Semen Cuscutae 25-35 part, Semen Sesami 25-35 part, Semen Castaneae 15-25 part, Rhizoma Dioscoreae 15-25 part, Semen Juglandis 15-25 part, Arillus Longan 15-25 part, Radix Codonopsis 15-25 part, Semen Coicis 15-25 part, Radix Rhapontici 15-25 part, Rhizoma Polygoni Cuspidati 15-25 part, Radix Astragali 15-25 part, Radix Rehmanniae 15-25 part, Stichopus japonicus 350-450 part.

  

Object lesson 1

30 parts of the Cortexs Eucommiae, 20 parts of the Radix Paeoniae Albas, 20 parts of Semen Cuscutae, 20 parts of Semen Sesamis, 10 parts, Semen Castaneae, 10 parts of Rhizoma Dioscoreaes, 10 parts of Semen Juglandiss, 10 parts of Arillus Longan, 10 parts of Radix Codonopsis, 10 parts of Semen Coiciss, 10 parts of Radix Rhapontici, 10 parts of Rhizoma Polygoni Cuspidati, 10 parts of the Radixs Astragali, 10 parts of Radix Rehmanniae, 300 parts of Stichopus japonicuss.

Preparation method,

The step of A, cleaning: by the Cortex Eucommiae, the Radix Paeoniae Alba, Semen Cuscutae, Semen Sesami, Semen Castaneae, Rhizoma Dioscoreae, Semen Juglandis, Arillus Longan, Radix Codonopsis, Semen Coicis, Radix Rhapontici, Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Rehmanniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 3-5 minute, avoids drug effect to run off;

The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;

C, above-mentioned component add 10 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;

The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;

In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,

E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mix homogeneously, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicated powder, then medicated powder is incapsulated according to every capsule 5-8g.

  

Object lesson 2

50 parts of the Cortexs Eucommiae, 40 parts of the Radix Paeoniae Albas, 40 parts of Semen Cuscutae, 40 parts of Semen Sesamis, 30 parts, Semen Castaneae, 30 parts of Rhizoma Dioscoreaes, 30 parts of Semen Juglandiss, 30 parts of Arillus Longan, 30 parts of Radix Codonopsis, 30 parts of Semen Coiciss, 30 parts of Radix Rhapontici, 30 parts of Rhizoma Polygoni Cuspidati, 30 parts of the Radixs Astragali, 30 parts of Radix Rehmanniae, 500 parts of Stichopus japonicuss.

Preparation method,

The step of A, cleaning: by the Cortex Eucommiae, the Radix Paeoniae Alba, Semen Cuscutae, Semen Sesami, Semen Castaneae, Rhizoma Dioscoreae, Semen Juglandis, Arillus Longan, Radix Codonopsis, Semen Coicis, Radix Rhapontici, Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Rehmanniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 3-5 minute, avoids drug effect to run off;

The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;

C, above-mentioned component add 10 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;

The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;

In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,

E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mix homogeneously, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicated powder, then medicated powder is incapsulated according to every capsule 5-8g.

  

Object lesson 3

40 parts of the Cortexs Eucommiae, 30 parts of the Radix Paeoniae Albas, 30 parts of Semen Cuscutae, 30 parts of Semen Sesamis, 20 parts, Semen Castaneae, 20 parts of Rhizoma Dioscoreaes, 20 parts of Semen Juglandiss, 20 parts of Arillus Longan, 20 parts of Radix Codonopsis, 20 parts of Semen Coiciss, 20 parts of Radix Rhapontici, 20 parts of Rhizoma Polygoni Cuspidati, 20 parts of the Radixs Astragali, 20 parts of Radix Rehmanniae, 400 parts of Stichopus japonicuss.

Preparation method,

The step of A, cleaning: by the Cortex Eucommiae, the Radix Paeoniae Alba, Semen Cuscutae, Semen Sesami, Semen Castaneae, Rhizoma Dioscoreae, Semen Juglandis, Arillus Longan, Radix Codonopsis, Semen Coicis, Radix Rhapontici, Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Rehmanniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 3-5 minute, avoids drug effect to run off;

The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;

C, above-mentioned component add 10 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;

The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;

In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,

E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mix homogeneously, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicated powder, then medicated powder is incapsulated according to every capsule 5-8g.

  

Result of use for example

1, Zhang, 46 years old, man, nocturia urine amount polyuria amount is too much or very few, and (normal urine amount is 1000-2000 milliliters/days, about 1500 milliliters/day of average out to.Hydrouria or minimizing may be all the performance of nephropathy, the particularly polyuria at night signals of nephropathy often.) usually feel dizzy, lumbago lower limb is soft, black eye, easily alopecia.Play eyelid or facial edema morning, in the afternoon disappear more, tired postemphasis, alleviates after rest.

Take the prepared sea cucumber nutrient capsule of the present embodiment 1, each sooner or later of every day, take after 15 days, edema disappears, continue to take 15 days, the soft transference cure of lumbago lower limb, in high spirits, light-footedness, sleep well, clear-headed and clear-sighted.

  

2, Liu, 52 years old, headache, giddy, dim eyesight, tinnitus, the abnormal routine urianlysis of urine chemical examination finds that there is albumen, and because of the soreness of the waist and knees that kidney-yang deficiency causes, weakness of the lower extremities, has a dizzy spell, the symptoms such as hands and feet being not warm.

Take the high nourishing capsule of the prepared Stichopus japonicus of the present embodiment 2, each sooner or later of every day, take after 15 days, tinnitus disappears, and continues to take soreness of the waist and knees, weakness of the lower extremities transference cure 15 days.

  

3, Huang, 31 years old, excess of sexual intercourse, the brains that cause because of deficiency of kidney-essence do not fill, insomnia forgetfulness, the symptoms such as dizziness and tinnitus.

Take the high nourishing capsule of Stichopus japonicus that the present embodiment 3 makes, each sooner or later of every day, take after 15 days, insomnia disappears, and continues to take dizzy transference cure 10 days.

  

4, Wang, 39 years old, the soreness of the waist and knees that weakness of the spleen and kidney causes, dizziness and tinnitus, poor appetite, dim complexion, weak asthenia, urine amount is very few, and (normal urine amount is 1000-2000 milliliters/days, about 1500 milliliters/day of average out to.Hydrouria or minimizing may be all the performance of nephropathy, the particularly polyuria at night signals of nephropathy often.）。

Take the high nourishing capsule of the Stichopus japonicus making shown in the present embodiment 1, each sooner or later of every day, take after 20 days, malaise symptoms disappears.

  

Data comparison: following crowd's age is 40-50 year.

By step C gained traditional Chinese medicine liquid, crowd 20 people that suffer from a deficiency of the kidney take, as A group,

By step D gained sea cucumber extract, crowd 20 people that suffer from a deficiency of the kidney take, as B group

20 people take traditional traditional beche-de-mer capsules, as C group,

20 people's beche-de-mers, one for each person every day, as D group.

Concrete example 1 is taken for 20 people that suffer from a deficiency of the kidney, as E group.

Concrete example 2 is taken for 20 people that suffer from a deficiency of the kidney, as F group.

Concrete example 3 is taken for 20 people that suffer from a deficiency of the kidney, as G group.

Take continuously after 30 days, be compared as follows

Immunity comparison

Select 10 white mice feeding tradition holothurian oral liquids as a control group,

Select 10 white mice feedings the present invention group as a comparison.

Be compared as follows:

Wherein, the absorption of comparable group calcium and mineral is fast, and propagation bacillus bifidus, lactobacillus number is many, and the index of blood fat, blood glucose, cholesterol regulating is low compared with matched group.3-5 is placed in dark environment and the environment that is exposed to the sun repeatedly in day, the matched group probability of catching an illness is large, so comparable group immunity is strong.

  

Advantage of the present invention is: proportioning is simple, prescription collocation rationally, the kidney invigorating and essence nourishing, the strong sun of YIN nourishing, nourishing blood for moistening dryness, regulating menstruation dispel labor, improve body immunity.Be specially:

The present invention adds Chinese medicine powder on the basis of sea cucumber extract, after fully dissolving, again the sea cucumber extract preparation that is dissolved with Chinese medicine powder is become to dry extract, after dry, obtain medicated powder, medicated powder obtains the present invention after capsule subpackage, Chinese prescription the kidney invigorating and essence nourishing of the present invention, the strong sun of YIN nourishing, and, pass through kidney channel, (traditional Chinese medical science thinks that liver not directly mends for spleen channel and then nourishing the liver, one mends and to get angry, and spleen reinforcing, the kidney invigorating get final product nourishing the liver) in kidney tonifying nourishing YIN and supplementing blood not, add the medicine that appropriateness is taken good care of liver, total tune internal organs environment, increases immunity.

Claims (5)

1. a sea cucumber nutrient capsule, is characterized in that, comprises according to the following active component of parts by weight configuration:

Cortex Eucommiae 30-50 part, Radix Paeoniae Alba 20-40 part, Semen Cuscutae 20-40 part, Semen Sesami 20-40 part, Semen Castaneae 10-30 part, Rhizoma Dioscoreae 10-30 part, Semen Juglandis 10-30 part, Arillus Longan 10-30 part, Radix Codonopsis 10-30 part, Semen Coicis 10-30 part, Radix Rhapontici 10-30 part, Rhizoma Polygoni Cuspidati 10-30 part, Radix Astragali 10-30 part, Radix Rehmanniae 10-30 part, Stichopus japonicus 300-500 part.

2. sea cucumber nutrient capsule according to claim 1, is characterized in that, comprises according to the following active component of parts by weight configuration:

Cortex Eucommiae 30-40 part, Radix Paeoniae Alba 20-30 part, Semen Cuscutae 20-30 part, Semen Sesami 20-30 part, Semen Castaneae 10-20 part, Rhizoma Dioscoreae 10-20 part, Semen Juglandis 10-20 part, Arillus Longan 10-20 part, Radix Codonopsis 10-20 part, Semen Coicis 10-20 part, Radix Rhapontici 10-20 part, Rhizoma Polygoni Cuspidati 10-20 part, Radix Astragali 10-20 part, Radix Rehmanniae 10-20 part, Stichopus japonicus 300-400 part.

3. sea cucumber nutrient capsule according to claim 1, is characterized in that, comprises according to the following active component of parts by weight configuration:

Cortex Eucommiae 40-50 part, Radix Paeoniae Alba 30-40 part, Semen Cuscutae 30-40 part, Semen Sesami 30-40 part, Semen Castaneae 20-30 part, Rhizoma Dioscoreae 20-30 part, Semen Juglandis 20-30 part, Arillus Longan 20-30 part, Radix Codonopsis 20-30 part, Semen Coicis 20-30 part, Radix Rhapontici 20-30 part, Rhizoma Polygoni Cuspidati 20-30 part, Radix Astragali 20-30 part, Radix Rehmanniae 20-30 part, Stichopus japonicus 400-500 part.

4. sea cucumber nutrient capsule according to claim 1, is characterized in that, comprises according to the following active component of parts by weight configuration:

Cortex Eucommiae 35-45 part, Radix Paeoniae Alba 25-35 part, Semen Cuscutae 25-35 part, Semen Sesami 25-35 part, Semen Castaneae 15-25 part, Rhizoma Dioscoreae 15-25 part, Semen Juglandis 15-25 part, Arillus Longan 15-25 part, Radix Codonopsis 15-25 part, Semen Coicis 15-25 part, Radix Rhapontici 15-25 part, Rhizoma Polygoni Cuspidati 15-25 part, Radix Astragali 15-25 part, Radix Rehmanniae 15-25 part, Stichopus japonicus 350-450 part.

5. according to the preparation method of the arbitrary described sea cucumber nutrient capsule of claim 1-4, it is characterized in that, comprise the steps:

The step of A, cleaning: by the Cortex Eucommiae, the Radix Paeoniae Alba, Semen Cuscutae, Semen Sesami, Semen Castaneae, Rhizoma Dioscoreae, Semen Juglandis, Arillus Longan, Radix Codonopsis, Semen Coicis, Radix Rhapontici, Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Rehmanniae, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 3-5 minute, avoids drug effect to run off;

The step of B, demulcen: the Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;

C, above-mentioned component add 10 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when the relative density of filtrate is 20 ℃ 1.08; The macroporous adsorptive resins that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water eluting of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;

The step of D, Stichopus japonicus deep processing: fresh and alive sea cucumbers, along abdominal part from first to last complete section open, gill, impurity is cleaned up; Then carry out lyophilization, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and quick freezing 2-3h puts into pulverizer by the Stichopus japonicus after lyophilization, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick Stichopus japonicus powder; Stichopus japonicus coarse powder is carried out to micronizing by jet mill, and time 2-3h, obtains ultra micro Stichopus japonicus powder; Then ultra micro Stichopus japonicus powder is carried out to nanorize pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;

In container, add pure water, Stichopus japonicus powder after nanorize is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of Stichopus japonicus weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis solution rapidly degree of intensification to 90 ℃ of enzyme denaturing 10-30min, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis solution is cooled to rapidly to room temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis solution, enzymolysis solution after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,

E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mix homogeneously, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicated powder, then medicated powder is incapsulated according to every capsule 5-8g.