CN103610076A - Preparation method for sea cucumber capsule - Google Patents
Preparation method for sea cucumber capsule Download PDFInfo
- Publication number
- CN103610076A CN103610076A CN201310490969.7A CN201310490969A CN103610076A CN 103610076 A CN103610076 A CN 103610076A CN 201310490969 A CN201310490969 A CN 201310490969A CN 103610076 A CN103610076 A CN 103610076A
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- Prior art keywords
- sea cucumber
- ethanol
- powder
- filtrate
- extract
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- 238000012546 transfer Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
A provided preparation method for a sea cucumber capsule comprises the following steps: material preparation: selecting high-quality traditional Chinese medicine compositions shown in the specification and sea cucumber for reservation; A, step of cleaning; B, step of medicine infiltrating; C, adding ethanol accounting for 8 times by weight of the above compositions, heating, refluxing and extracting for 2 hours for 3 times, merging the three time extract, performing reduced-pressure distillation to recover ethanol, concentrating to a soup concentration of 0.5 g crude drug/mL, filtering to get a filtrate with relative density of 1.1 at 20 DEG C, enabling the filtrate flow through a macroporous adsorption resin column with a volume of 10 L, eluting with deionized water or distilled water accounting for 10 times by volume of the resin column, eluting with 95% ethanol accounting for 5 times by volume of the resin column, collecting ethanol eluate, and removing the ethanol solvent to obtain a traditional Chinese medicine powder; D, step of sea cucumber deep processing: obtaining the sea cucumber extract; and E, step of capsule preparation. The preparation method is simple; and the prepared product is simple in ratio and reasonable in formula matching, and is capable of tonifying kidney, enriching essence, nourishing yin, fortifying yang, tonifying blood, moistening dryness, regulating menstruation, dispelling fatigue and improving human body immunity.
Description
technical field:
The present invention relates to sea cucumber deep process technology field, relate in particular to a kind of manufacture method of beche-de-mer capsules.
background technology:
Modern scientific research proves, sea cucumber nutrient is worth very high, in every hectogram, contain 15 grams, protein, 1 gram, fat, 0.4 gram, carbohydrate, 357 milligrams of calcium, 12 milligrams, phosphorus, 2.4 milligrams of iron, and vitamin B1, B2, more than the 50 kind of nutritional labeling useful to human physiological activity such as niacin, wherein protein content is up to more than 55%, it contains 18 seed amino acid taurines, chondroitin sulfate, stichopus japonicus mucopolysaccharide Multiple components, arginine is the main component that forms male sex's spermatid, it is again the primary raw material of synthesized human collagen, reparation after can promoting the regeneration of body cell and body impaired, can also improve the immunologic function of human body, promote longevity, eliminate tired.
Sea cucumber is extremely low containing cholesterol, is a kind of typical high protein, low fat, low cholesterol food.Add its fine and tender taste, be easy to digestion, so, be suitable for very much the elderly, children and the people that has a delicate constitution edible.Sea cucumber, because of extremely low containing cholesterol, is the food of a kind of typical high protein, low fat, low cholesterol.Because of fine and tender taste, be easy to digestion again, thus be applicable to very much the elderly and children, and the person of having a delicate constitution is edible.Taurine in sea cucumber, niacin etc.; there is the nervous system of adjusting, elimination fatigue fast; the effect of prevention skin aging; the taurine containing in sea cucumber in addition, lysine, methionine etc. almost do not have in vegetable food; the chondroitin sulfate containing in stichopus japonicus and stichopus japonicus mucopolysaccharide; by pharmacological evaluation, prove, to the growing of human body, anti-inflammatory skeletonization and prevention failure, promoting wound healing to suppress several cancer cells has special efficacy.Continuity is old and feeble, eliminate tired, improve immunity, the ability sea cucumber that strengthens resist the disease is rich in the natural precious active materials of kind more than 50 such as protein, mineral matter, vitamin, wherein acid mucopolysaccharide and chondroitin can obviously reduce the quantity of lipofuscin and skin proline in heart tissue, play the effect delaying senility.In sea cucumber body, 18 contained seed amino acids can strengthen the metabolic function of tissue, and enhanced machine body cell vigor, is suitable for the teenager in growing.Sea cucumber energy balance the body water balance, is suitable for the Ms of pregnancy period legs and feet edema.Sea cucumber can be eliminated tired, improves body immunity, strengthens the ability of human body resist the disease, is therefore applicable to very much often middle aged Ms and the man in fatigue state, the sub-health populations such as easy catching a cold, the elderly who has a delicate constitution and children.
Sea cucumber is not only delicious food, and is good tonic.Taurine in sea cucumber, lysine etc. almost do not have in vegetable food.The distinctive active material holothurin of sea cucumber, has significant inhibitory action to multiple fungi, has significant anti-inflammatory, osteogenic action, especially hepatitis, tuberculosis, diabetes, cardiovascular disease is had significant therapeutic effect.In brain healthy, practise midwifery lactagogue stichopus japonicus, contain two kinds of omega-3-polyunsaturated fatty acids (EPA and DHA).Wherein DHA plays vital effect to fetal brain cell development.Human brain is grown and is started from pregnant three month, and fetus obtains DHA and EPA from parent by placenta.If parent lacks DHA, can cause the Phospholipids of fetal brain cell not enough, affect the normal development of fetal central nervous system.DHA has significant benifit to strengthening memory and IQ, but also can make pregnant and lying-in women's breast enlargement, and milk is full.
Other functions of sea cucumber, as eliminated tumour, the anticancer heart that protects: contain a large amount of holothurins in the tissues such as body wall, internal organ and body of gland of sea cucumber, be again Sea Cucumber Glycosides.Holothurin is a kind of counterpoison, nontoxic to human-body safety, but growth and the transfer of energy inhibition tumor cell, effectively anti-cancer, anticancer, has been widely used in the treatment of liver cancer, lung cancer, cancer of the stomach, nasopharyngeal carcinoma, osteocarcinoma, lymph cancer, oophoroma, the cancer of the uterus, breast cancer, cancer of the brain leukaemia and hand postoperative patient clinically.Improve the frequent beche-de-mer of osteoporosis and can prevent children's rickets, adult's osteoporosis and hyperostosis.In gold most distinguished sea cucumber, the element such as abundant calcium, phosphorus, manganese, copper, germanium, silicon is to prevention Infant Rickets, adult's osteoporosis and to skeletal abnormality, deformity, and dentine and enamel development be bad special role.Enhancing development beche-de-mer helps lend some impetus to and grows.Abundant arginine, lysine, taurine, calcium, phosphorus, iodine, iron, zinc in sea cucumber; it is the important substance that human development grows up; they participate in the physiological activities such as the growing of human body itself, immune regulation, wound healing, reproductive development directly, in body energy deposit and running, play an important role.
Sea cucumber as in Chinese medicine simply, widely recorded, as, < < new compilation of materia medica > >: tonifying kidney and benefiting sperm, impotence is treated in establishing-Yang.The < < property of medicine is examined > >: fall fiery nourshing kidney, logical intestines are moisturized, except the timid disease of labor.< < food compatibility and incompatibility of drugs > >: kidney tonifying warp, beneficial marrow, dissolving phlegm saliva, takes the photograph urine, and impotence is treated in establishing-Yang, kills sore worm.The < < detailed outline > > that picks up any lost article from the road: raw hundred arteries and veins blood, control recurrent dysentery.< < book on Chinese herbal medicine is asked former > >: moisturizing viscera, grow smart Li Shui.< < occupies diet spectrum > > with breath: enriching yin, to enrich blood, and strong sun, moisturizes, menstruation regulating, nourishing the fetus, profit is produced.All postpartum,, should simmer food with ham or pig mutton.The modern Practical Chinese medicinal > of < < > nature and flavor: cold nature, taste is sweet, salty.Return lung, kidney, large intestine channel.Tonifying kidney and benefiting sperm; Enriching the blood to restore normal menstruation; Hemostasis.Cure mainly: essence and blood loss; Weak labor is timid; Impotence; Nocturnal emission; The dry constipation of intestines; Cough due to deficiency of the lung's spitting of blood, hematochezia, traumatism and bleeding.
Sea cucumber contains outside protein, calcium, potassium, zinc, iron, selenium, manganese isoreactivity material, and other active component is by holothurin and by amidohexose, uronic acid and fucose etc. form Stichopus Japonicus Acidic Mucopolysaccharide, separately containing 18 seed amino acids and do not contain cholesterol in sea cucumber body.Because sea cucumber is warm in nature, there is the strong sun of tonifying kidney and benefiting sperm, enriching yin, nourishing blood for moistening dryness, the menstruation regulating tonifying both YIN and YANG effects such as labor, nourishing the fetus profit product of dispelling.Can improve male endocrine ability, improve women's metabolism, promote sex hormone secretion ability, improve sexual function.From traditional Chinese medical science angle, kidney is basis of human body, as long as kidney goes wrong, be not only the problem that life quality reduces, and other organs can corresponding exhaustion.And sea cucumber is to the main reinforcing kidney and strengthening resistance of the effect of human body, the element culturing fixed folder of namely as the saying goes.As long as human kidney is strong, each organ channels and collaterals all can be corresponding strong, and final people knows from experience more healthy, and the ability of resist the disease strengthens greatly.
The instructions of taking of sea cucumber, still take tonic as main at present, and tonic causes human absorptivity not enough, and the taboo of some culinary arts also usually causes the loss of sea cucumber nutrient composition, as, sea cucumber can not be cooked flavouring with vinegar.Therefore, there are on the market some sea cucumber deep processed products, as oral liquid, tablet, capsule, honey refining pill etc., in the process of deep processing, often adds Chinese patent drug to improve the absorptivity of product or to increase other auxiliary functions, but, some formula is unreasonable, for example, sea cucumber can not with Radix Glycyrrhizae compatibility etc.Therefore, it is simple that the present invention aims to provide a kind of manufacture method, and the product proportioning making is simple, prescription collocation rationally, tonifying kidney and benefiting sperm, the strong sun of enriching yin, nourishing blood for moistening dryness, menstruation regulating dispel labor, improve the manufacture method of a kind of beche-de-mer capsules of body immunity.
summary of the invention:
The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of manufacture method simple, the product proportioning making is simple, and prescription collocation rationally, the strong sun of tonifying kidney and benefiting sperm, enriching yin, nourishing blood for moistening dryness, menstruation regulating dispel labor, improve the manufacture method of a kind of beche-de-mer capsules of body immunity.
To achieve these goals, the invention provides a kind of manufacture method of beche-de-mer capsules, wherein, comprise the steps:
Get the raw materials ready, select following traditional Chinese medicinal components and the sea cucumber of high-quality, standby:
The step of A, cleaning: by dried scallop, mulberries, Gorgon fruit, Chinese caterpillar fungus, fries lotus seeds, cynomorium songaricum, auricularia auriculajudae, rhizoma Gastrodiae, the root bark of tree peony, cape jasmine, field pennycress, curcuma zedoary, saline cistanche, lily, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 2-3 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 1-1.5 hour, for abstraction process creates conditions;
C, above-mentioned component add 8 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.1; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mixing, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicinal powder, then medicinal powder is incapsulated according to every capsule 10g.
The beche-de-mer capsules making through manufacture method of the present invention, wherein, comprises according to the following active component of parts by weight configuration:
Dried scallop 30-50 part, mulberries 20-40 part, Gorgon fruit 20-40 part, Chinese caterpillar fungus 20-40 part, fries lotus seeds 10-30 part, cynomorium songaricum 10-30 part, auricularia auriculajudae 10-30 part, rhizoma Gastrodiae 10-30 part, root bark of tree peony 10-30 part, cape jasmine 10-30 part, field pennycress 10-30 part, curcuma zedoary 10-30 part, saline cistanche 10-30 part, lily 10-30 part, sea cucumber 300-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Dried scallop 30-40 part, mulberries 20-30 part, Gorgon fruit 20-30 part, Chinese caterpillar fungus 20-30 part, fries lotus seeds 10-20 part, cynomorium songaricum 10-20 part, auricularia auriculajudae 10-20 part, rhizoma Gastrodiae 10-20 part, root bark of tree peony 10-20 part, cape jasmine 10-20 part, field pennycress 10-20 part, curcuma zedoary 10-20 part, saline cistanche 10-20 part, lily 10-20 part, sea cucumber 300-400 part.
Or, comprise according to the following active component of parts by weight configuration:
Dried scallop 40-50 part, mulberries 30-40 part, Gorgon fruit 30-40 part, Chinese caterpillar fungus 30-40 part, fries lotus seeds 20-30 part, cynomorium songaricum 20-30 part, auricularia auriculajudae 20-30 part, rhizoma Gastrodiae 20-30 part, root bark of tree peony 20-30 part, cape jasmine 20-30 part, field pennycress 20-30 part, curcuma zedoary 20-30 part, saline cistanche 20-30 part, lily 20-30 part, sea cucumber 400-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Dried scallop 35-45 part, mulberries 25-35 part, Gorgon fruit 25-35 part, Chinese caterpillar fungus 25-35 part, fries lotus seeds 15-25 part, cynomorium songaricum 15-25 part, auricularia auriculajudae 15-25 part, rhizoma Gastrodiae 15-25 part, root bark of tree peony 15-25 part, cape jasmine 15-25 part, field pennycress 15-25 part, curcuma zedoary 15-25 part, saline cistanche 15-25 part, lily 15-25 part, sea cucumber 350-450 part.
Advantage of the present invention is: manufacture method is simple, and the product proportioning making is simple, prescription collocation rationally, tonifying kidney and benefiting sperm, the strong sun of enriching yin, nourishing blood for moistening dryness, menstruation regulating dispel labor, improve body immunity.Be specially:
The present invention adds traditional Chinese medicine powder on the basis of sea cucumber extract, after fully dissolving, again the sea cucumber extract preparation that is dissolved with traditional Chinese medicine powder is become to dry extract, after dry, obtain medicinal powder, medicinal powder obtains the present invention after capsule subpackage, Chinese prescription tonifying kidney and benefiting sperm of the present invention, the strong sun of enriching yin, and, pass through kidney channel, (traditional Chinese medical science thinks that liver not directly mends for the spleen channel and then nourishing the liver, one mends and to get angry, and tonifying spleen, kidney tonifying get final product nourishing the liver) in kidney-nourishing nourishing yin and supplementing blood not, add the medicine that appropriateness is taken good care of liver, total tune internal organ environment, increases immunity.
the specific embodiment:
Beche-de-mer capsules, wherein, comprises according to the following active component of parts by weight configuration:
Dried scallop 30-50 part, mulberries 20-40 part, Gorgon fruit 20-40 part, Chinese caterpillar fungus 20-40 part, fries lotus seeds 10-30 part, cynomorium songaricum 10-30 part, auricularia auriculajudae 10-30 part, rhizoma Gastrodiae 10-30 part, root bark of tree peony 10-30 part, cape jasmine 10-30 part, field pennycress 10-30 part, curcuma zedoary 10-30 part, saline cistanche 10-30 part, lily 10-30 part, sea cucumber 300-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Dried scallop 30-40 part, mulberries 20-30 part, Gorgon fruit 20-30 part, Chinese caterpillar fungus 20-30 part, fries lotus seeds 10-20 part, cynomorium songaricum 10-20 part, auricularia auriculajudae 10-20 part, rhizoma Gastrodiae 10-20 part, root bark of tree peony 10-20 part, cape jasmine 10-20 part, field pennycress 10-20 part, curcuma zedoary 10-20 part, saline cistanche 10-20 part, lily 10-20 part, sea cucumber 300-400 part.
Or, comprise according to the following active component of parts by weight configuration:
Dried scallop 40-50 part, mulberries 30-40 part, Gorgon fruit 30-40 part, Chinese caterpillar fungus 30-40 part, fries lotus seeds 20-30 part, cynomorium songaricum 20-30 part, auricularia auriculajudae 20-30 part, rhizoma Gastrodiae 20-30 part, root bark of tree peony 20-30 part, cape jasmine 20-30 part, field pennycress 20-30 part, curcuma zedoary 20-30 part, saline cistanche 20-30 part, lily 20-30 part, sea cucumber 400-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Dried scallop 35-45 part, mulberries 25-35 part, Gorgon fruit 25-35 part, Chinese caterpillar fungus 25-35 part, fries lotus seeds 15-25 part, cynomorium songaricum 15-25 part, auricularia auriculajudae 15-25 part, rhizoma Gastrodiae 15-25 part, root bark of tree peony 15-25 part, cape jasmine 15-25 part, field pennycress 15-25 part, curcuma zedoary 15-25 part, saline cistanche 15-25 part, lily 15-25 part, sea cucumber 350-450 part.
Object lesson 1
30 parts, dried scallop, 20 parts of mulberries, 20 parts of Gorgon fruits, 20 parts of Chinese caterpillar funguses, fry 10 parts, lotus seeds, 10 parts of cynomorium songaricums, 10 parts, auricularia auriculajudae, 10 parts, rhizoma Gastrodiae, 10 parts of the root barks of tree peony, 10 parts of cape jasmines, 10 parts of field pennycress, 10 parts of curcuma zedoarys, 10 parts of saline cistanches, 10 parts of lilies, 300 parts of sea cucumbers.
Preparation method,
Get the raw materials ready, select following traditional Chinese medicinal components and the sea cucumber of high-quality, standby:
The step of A, cleaning: by dried scallop, mulberries, Gorgon fruit, Chinese caterpillar fungus, fries lotus seeds, cynomorium songaricum, auricularia auriculajudae, rhizoma Gastrodiae, the root bark of tree peony, cape jasmine, field pennycress, curcuma zedoary, saline cistanche, lily, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 2-3 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 1-1.5 hour, for abstraction process creates conditions;
C, above-mentioned component add 8 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.1; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mixing, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicinal powder, then medicinal powder is incapsulated according to every capsule 10g.
Object lesson 2
50 parts, dried scallop, 40 parts of mulberries, 40 parts of Gorgon fruits, 40 parts of Chinese caterpillar funguses, fry 30 parts, lotus seeds, 30 parts of cynomorium songaricums, 30 parts, auricularia auriculajudae, 30 parts, rhizoma Gastrodiae, 30 parts of the root barks of tree peony, 30 parts of cape jasmines, 30 parts of field pennycress, 30 parts of curcuma zedoarys, 30 parts of saline cistanches, 30 parts of lilies, 500 parts of sea cucumbers.
Preparation method,
Get the raw materials ready, select following traditional Chinese medicinal components and the sea cucumber of high-quality, standby:
The step of A, cleaning: by dried scallop, mulberries, Gorgon fruit, Chinese caterpillar fungus, fries lotus seeds, cynomorium songaricum, auricularia auriculajudae, rhizoma Gastrodiae, the root bark of tree peony, cape jasmine, field pennycress, curcuma zedoary, saline cistanche, lily, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 2-3 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 1-1.5 hour, for abstraction process creates conditions;
C, above-mentioned component add 8 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.1; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mixing, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicinal powder, then medicinal powder is incapsulated according to every capsule 10g.
Object lesson 3
40 parts, dried scallop, 30 parts of mulberries, 30 parts of Gorgon fruits, 30 parts of Chinese caterpillar funguses, fry 20 parts, lotus seeds, 20 parts of cynomorium songaricums, 20 parts, auricularia auriculajudae, 20 parts, rhizoma Gastrodiae, 20 parts of the root barks of tree peony, 20 parts of cape jasmines, 20 parts of field pennycress, 20 parts of curcuma zedoarys, 20 parts of saline cistanches, 20 parts of lilies, 400 parts of sea cucumbers.
Preparation method,
Get the raw materials ready, select following traditional Chinese medicinal components and the sea cucumber of high-quality, standby:
The step of A, cleaning: by dried scallop, mulberries, Gorgon fruit, Chinese caterpillar fungus, fries lotus seeds, cynomorium songaricum, auricularia auriculajudae, rhizoma Gastrodiae, the root bark of tree peony, cape jasmine, field pennycress, curcuma zedoary, saline cistanche, lily, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 2-3 minute, avoids drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 1-1.5 hour, for abstraction process creates conditions;
C, above-mentioned component add 8 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.1; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mixing, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicinal powder, then medicinal powder is incapsulated according to every capsule 10g.
Result of use for example
1, Zhang, 46 years old, man, enuresis nocturna urine amount diuresis amount is too much or very few, and (normal urine amount is 1000-2000 milliliters/days, about 1500 milliliters/day of average out to.Hydrouria or minimizing may be all the performance of kidney trouble, the particularly polyuria at night signals of kidney trouble often.) usually feel dizzy, pain in the back leg is soft, black eye, easily alopecia.Play eyelid or facial edema morning, in the afternoon disappear more, tired postemphasis, alleviates after rest.
Take the prepared beche-de-mer capsules of the present embodiment 1, each sooner or later of every day, take after 15 days, oedema disappears, continue to take 15 days, the soft transference cure of pain in the back leg, in high spirits, light-footedness, sleep well, clear-headed and clear-sighted.
2, Liu, 52 years old, headache, giddy, dim eyesight, tinnitus, the abnormal routine urianlysis of urine chemical examination finds that there is albumen, and because of the soreness and weakness of waist and knees that kidney-yang deficiency causes, weakness of the lower extremities, has a dizzy spell, the symptoms such as hands and feet being not warm.
Take the high nourishing capsule of the prepared sea cucumber of the present embodiment 2, each sooner or later of every day, take after 15 days, tinnitus disappears, and continues to take soreness and weakness of waist and knees, weakness of the lower extremities transference cure 15 days.
3, Huang, 31 years old, excess of sexual intercourse,indulgence in sexual activities, the brains that cause because of deficiency of kidney-essence do not fill, insomnia forgetfulness, the symptoms such as dizziness and tinnitus.
Take the high nourishing capsule of sea cucumber that the present embodiment 3 makes, each sooner or later of every day, take after 15 days, insomnia disappears, and continues to take dizzy transference cure 10 days.
4, Wang, 39 years old, the soreness and weakness of waist and knees that spleen causes a little less than suffering from a deficiency of the kidney, dizziness and tinnitus, Na Gu is not fragrant, dim complexion, weak burnout, urine amount is very few, and (normal urine amount is 1000-2000 milliliters/days, about 1500 milliliters/day of average out to.Hydrouria or minimizing may be all the performance of kidney trouble, the particularly polyuria at night signals of kidney trouble often.）。
Take the high nourishing capsule of the sea cucumber making shown in the present embodiment 1, each sooner or later of every day, take after 20 days, malaise symptoms disappears.
Data comparison: following crowd's age is 40-50 year.
By step C gained traditional Chinese medicine liquid, crowd 20 people that suffer from a deficiency of the kidney take, as A group,
By step D gained sea cucumber extract, crowd 20 people that suffer from a deficiency of the kidney take, as B group
20 people take traditional traditional beche-de-mer capsules, as C group,
20 people's beche-de-mers, one for each person every day, as D group.
Concrete example 1 is taken for 20 people that suffer from a deficiency of the kidney, as E group.
Concrete example 2 is taken for 20 people that suffer from a deficiency of the kidney, as F group.
Concrete example 3 is taken for 20 people that suffer from a deficiency of the kidney, as G group.
Take continuously after 30 days, be compared as follows
Immunity comparison
Select 10 small white mouse feeding tradition holothurian oral liquids as a control group,
Select 10 small white mouse feedings the present invention group as a comparison.
Be compared as follows:
Wherein, the absorption of comparative group calcium and mineral matter is fast, and propagation Bifidobacterium, lactic acid bacteria number is many, and the index of blood fat, blood sugar, adjusting cholesterol is low compared with control group.3-5 is placed in dark environment and the environment that is exposed to the sun repeatedly in day, the control group probability of catching an illness is large, so comparative group immunity is strong.
Advantage of the present invention is: manufacture method is simple, and the product proportioning making is simple, prescription collocation rationally, tonifying kidney and benefiting sperm, the strong sun of enriching yin, nourishing blood for moistening dryness, menstruation regulating dispel labor, improve body immunity.Be specially:
The present invention adds traditional Chinese medicine powder on the basis of sea cucumber extract, after fully dissolving, again the sea cucumber extract preparation that is dissolved with traditional Chinese medicine powder is become to dry extract, after dry, obtain medicinal powder, medicinal powder obtains the present invention after capsule subpackage, Chinese prescription tonifying kidney and benefiting sperm of the present invention, the strong sun of enriching yin, and, pass through kidney channel, (traditional Chinese medical science thinks that liver not directly mends for the spleen channel and then nourishing the liver, one mends and to get angry, and tonifying spleen, kidney tonifying get final product nourishing the liver) in kidney-nourishing nourishing yin and supplementing blood not, add the medicine that appropriateness is taken good care of liver, total tune internal organ environment, increases immunity.
Claims (1)
1. a manufacture method for beche-de-mer capsules, is characterized in that, comprises the steps:
Get the raw materials ready, select following traditional Chinese medicinal components and the sea cucumber of high-quality, standby:
The step of A, cleaning: by dried scallop, mulberries, Gorgon fruit, Chinese caterpillar fungus, fries lotus seeds, cynomorium songaricum, auricularia auriculajudae, rhizoma Gastrodiae, the root bark of tree peony, cape jasmine, field pennycress, curcuma zedoary, saline cistanche, lily, is used tumbling-box type medicine-washing machine to clean, and scavenging period is controlled at 2-3 minute, avoids drug effect to run off; The parts by weight of sea cucumber are 10 times of dried scallop;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and demulcen time 1-1.5 hour, for abstraction process creates conditions;
C, above-mentioned component add 8 times of weight amount ethanol, heating and refluxing extraction 3 times, and each 2 hours, No. 3 extracts are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is 20 ℃ 1.1; The large pore resin absorption column that described filtrate flow is 10L through volume, use afterwards deionized water or the distilled water wash-out of 10 times of resin column volumes, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove alcohol solvent, obtain Chinese medicinal powder, then after 80 order sieve, standby after ultraviolet sterilization;
The step of D, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
E, prepare the step of capsule: step C gained Chinese medicinal powder is joined in the sea cucumber extract of step D gained to Chinese medicinal powder: the weight ratio of sea cucumber extract is 1-1.2:1-1.5; Through centrifugal filtration, dry after mixing, obtain dry extract, cross 60 mesh sieves, put vacuum desiccator inner drying, after being dried, obtain medicinal powder, then medicinal powder is incapsulated according to every capsule 10g.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435359A (en) * | 2014-12-09 | 2015-03-25 | 山东好当家海洋发展股份有限公司 | Liver-protecting stichopus japonicus traditional Chinese medicine oral solution and preparation method thereof |
| CN104886586A (en) * | 2015-07-05 | 2015-09-09 | 青岛浩大海洋保健食品有限公司 | Kidney-tonifying and yang-invigorating abalone and scallop healthcare beverage |
| CN107751844A (en) * | 2017-09-28 | 2018-03-06 | 江苏晶王新材料科技有限公司 | A kind of preparation method of compound sea cucumber nutrient powder |
| CN112401167A (en) * | 2020-11-30 | 2021-02-26 | 福建御蓝记水产食品有限公司 | Easily-absorbed sea cucumber tablet and preparation method thereof |
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2013
- 2013-10-20 CN CN201310490969.7A patent/CN103610076A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435359A (en) * | 2014-12-09 | 2015-03-25 | 山东好当家海洋发展股份有限公司 | Liver-protecting stichopus japonicus traditional Chinese medicine oral solution and preparation method thereof |
| CN104435359B (en) * | 2014-12-09 | 2019-03-08 | 山东好当家海洋发展股份有限公司 | A kind of protect liver stichopus japonicus traditional Chinese medicine oral liquid and preparation method thereof |
| CN104886586A (en) * | 2015-07-05 | 2015-09-09 | 青岛浩大海洋保健食品有限公司 | Kidney-tonifying and yang-invigorating abalone and scallop healthcare beverage |
| CN107751844A (en) * | 2017-09-28 | 2018-03-06 | 江苏晶王新材料科技有限公司 | A kind of preparation method of compound sea cucumber nutrient powder |
| CN112401167A (en) * | 2020-11-30 | 2021-02-26 | 福建御蓝记水产食品有限公司 | Easily-absorbed sea cucumber tablet and preparation method thereof |
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