CN103610072A - Preparation method for blood-sugar-reducing sea cucumber oral liquid - Google Patents
Preparation method for blood-sugar-reducing sea cucumber oral liquid Download PDFInfo
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- CN103610072A CN103610072A CN201310490951.7A CN201310490951A CN103610072A CN 103610072 A CN103610072 A CN 103610072A CN 201310490951 A CN201310490951 A CN 201310490951A CN 103610072 A CN103610072 A CN 103610072A
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- sea cucumber
- filtrate
- sterilizing
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- root
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- 239000011691 vitamin B1 Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
A provided preparation method of a blood-sugar-reducing sea cucumber oral liquid comprises the following steps: preparing the following traditional Chinese medicine compositions: corn silk, achyranthcs bidentata blume, radix polygonum multiflorum, coptis, hemp seeds, tea root, taxillus, Chinese angelica, ginkgo biloba leaves, phytolacca acinosa roxb, andrographis paniculata, buffalo horn, leech, ligusticum wallichii and sea cucumber, wherein sea cucumber accounts for 10 times by weight of corn silk; A, step of cleaning; B, step of medicine infiltrating; C, step of decocting; D, adding ethanol with a mass percent concentration of 95% into a concentrate obtained in the step C, wherein the added amount of the ethanol is 10% by weight of the concentrate, to precipitate water-soluble impurities, and adding an additive; E, heating the filtrate of step D; F, step of sea cucumber deep processing for obtaining sea cucumber extract; and G, step of loading: mixing the traditional Chinese medicine soup obtained in the step E and the sea cucumber extract obtained in the step F according to a mass ratio of 1-1.5:1-2, performing centrifugation filtering again and sterilizing. The preparation method is simple; and the prepared product is simple in ratio and reasonable in formula matching, and is capable of adjusting human body function, reducing blood pressure well, reducing blood sugar well, reducing blood fat well, and enhancing human body immunity.
Description
technical field:
The present invention relates to sea cucumber deep process technology field, relate in particular to a kind of manufacture method of hypoglycemic holothurian oral liquid.
background technology:
Modern scientific research proves, sea cucumber nutrient is worth very high, in every hectogram, contain 15 grams, protein, 1 gram, fat, 0.4 gram, carbohydrate, 357 milligrams of calcium, 12 milligrams, phosphorus, 2.4 milligrams of iron, and vitamin B1, B2, more than the 50 kind of nutritional labeling useful to human physiological activity such as niacin, wherein protein content is up to more than 55%, it contains 18 seed amino acid taurines, chondroitin sulfate, stichopus japonicus mucopolysaccharide Multiple components, arginine is the main component that forms male sex's spermatid, it is again the primary raw material of synthesized human collagen, reparation after can promoting the regeneration of body cell and body impaired, can also improve the immunologic function of human body, promote longevity, eliminate tired.
Sea cucumber is extremely low containing cholesterol, is a kind of typical high protein, low fat, low cholesterol food.Add its fine and tender taste, be easy to digestion, so, be suitable for very much the elderly, children and the people that has a delicate constitution edible.Sea cucumber, because of extremely low containing cholesterol, is the food of a kind of typical high protein, low fat, low cholesterol.Because of fine and tender taste, be easy to digestion again, thus be applicable to very much the elderly and children, and the person of having a delicate constitution is edible.Taurine in sea cucumber, niacin etc.; there is the nervous system of adjusting, elimination fatigue fast; the effect of prevention skin aging; the taurine containing in sea cucumber in addition, lysine, methionine etc. almost do not have in vegetable food; the chondroitin sulfate containing in stichopus japonicus and stichopus japonicus mucopolysaccharide; by pharmacological evaluation, prove, to the growing of human body, anti-inflammatory skeletonization and prevention failure, promoting wound healing to suppress several cancer cells has special efficacy.Continuity is old and feeble, eliminate tired, improve immunity, the ability sea cucumber that strengthens resist the disease is rich in the natural precious active materials of kind more than 50 such as protein, mineral matter, vitamin, wherein acid mucopolysaccharide and chondroitin can obviously reduce the quantity of lipofuscin and skin proline in heart tissue, play the effect delaying senility.In sea cucumber body, 18 contained seed amino acids can strengthen the metabolic function of tissue, and enhanced machine body cell vigor, is suitable for the teenager in growing.Sea cucumber energy balance the body water balance, is suitable for the Ms of pregnancy period legs and feet edema.Sea cucumber can be eliminated tired, improves body immunity, strengthens the ability of human body resist the disease, is therefore applicable to very much often middle aged Ms and the man in fatigue state, the sub-health populations such as easy catching a cold, the elderly who has a delicate constitution and children.
Sea cucumber is not only delicious food, and is good tonic.Taurine in sea cucumber, lysine etc. almost do not have in vegetable food.The distinctive active material holothurin of sea cucumber, has significant inhibitory action to multiple fungi, has significant anti-inflammatory, osteogenic action, especially hepatitis, tuberculosis, diabetes, cardiovascular disease is had significant therapeutic effect.In brain healthy, practise midwifery lactagogue stichopus japonicus, contain two kinds of omega-3-polyunsaturated fatty acids (EPA and DHA).Wherein DHA plays vital effect to fetal brain cell development.Human brain is grown and is started from pregnant three month, and fetus obtains DHA and EPA from parent by placenta.If parent lacks DHA, can cause the Phospholipids of fetal brain cell not enough, affect the normal development of fetal central nervous system.DHA has significant benifit to strengthening memory and IQ, but also can make pregnant and lying-in women's breast enlargement, and milk is full.
Other functions of sea cucumber, as eliminated tumour, the anticancer heart that protects: contain a large amount of holothurins in the tissues such as body wall, internal organ and body of gland of sea cucumber, be again Sea Cucumber Glycosides.Holothurin is a kind of counterpoison, nontoxic to human-body safety, but growth and the transfer of energy inhibition tumor cell, effectively anti-cancer, anticancer, has been widely used in the treatment of liver cancer, lung cancer, cancer of the stomach, nasopharyngeal carcinoma, osteocarcinoma, lymph cancer, oophoroma, the cancer of the uterus, breast cancer, cancer of the brain leukaemia and hand postoperative patient clinically.Improve the frequent beche-de-mer of osteoporosis and can prevent children's rickets, adult's osteoporosis and hyperostosis.In gold most distinguished sea cucumber, the element such as abundant calcium, phosphorus, manganese, copper, germanium, silicon is to prevention Infant Rickets, adult's osteoporosis and to skeletal abnormality, deformity, and dentine and enamel development be bad special role.Enhancing development beche-de-mer helps lend some impetus to and grows.Abundant arginine, lysine, taurine, calcium, phosphorus, iodine, iron, zinc in sea cucumber; it is the important substance that human development grows up; they participate in the physiological activities such as the growing of human body itself, immune regulation, wound healing, reproductive development directly, in body energy deposit and running, play an important role.
Sea cucumber as in Chinese medicine simply, widely recorded, as, < < new compilation of materia medica > >: tonifying kidney and benefiting sperm, impotence is treated in establishing-Yang.The < < property of medicine is examined > >: fall fiery nourshing kidney, logical intestines are moisturized, except the timid disease of labor.< < food compatibility and incompatibility of drugs > >: kidney tonifying warp, beneficial marrow, dissolving phlegm saliva, takes the photograph urine, and impotence is treated in establishing-Yang, kills sore worm.The < < detailed outline > > that picks up any lost article from the road: raw hundred arteries and veins blood, control recurrent dysentery.< < book on Chinese herbal medicine is asked former > >: moisturizing viscera, grow smart Li Shui.< < occupies diet spectrum > > with breath: enriching yin, to enrich blood, and strong sun, moisturizes, menstruation regulating, nourishing the fetus, profit is produced.All postpartum,, should simmer food with ham or pig mutton.The modern Practical Chinese medicinal > of < < > nature and flavor: cold nature, taste is sweet, salty.Return lung, kidney, large intestine channel.Tonifying kidney and benefiting sperm; Enriching the blood to restore normal menstruation; Hemostasis.Cure mainly: essence and blood loss; Weak labor is timid; Impotence; Nocturnal emission; The dry constipation of intestines; Cough due to deficiency of the lung's spitting of blood, hematochezia, traumatism and bleeding.
Sea cucumber contains outside protein, calcium, potassium, zinc, iron, selenium, manganese isoreactivity material, and other active component is by holothurin and by amidohexose, uronic acid and fucose etc. form Stichopus Japonicus Acidic Mucopolysaccharide, separately containing 18 seed amino acids and do not contain cholesterol in sea cucumber body.Because sea cucumber is warm in nature, there is the strong sun of tonifying kidney and benefiting sperm, enriching yin, nourishing blood for moistening dryness, the menstruation regulating tonifying both YIN and YANG effects such as labor, nourishing the fetus profit product of dispelling.Can improve male endocrine ability, improve women's metabolism, promote sex hormone secretion ability, improve sexual function.From traditional Chinese medical science angle, kidney is basis of human body, as long as kidney goes wrong, be not only the problem that life quality reduces, and other organs can corresponding exhaustion.And palace product sea cucumber is to the main reinforcing kidney and strengthening resistance of the effect of human body, the element culturing fixed folder of namely as the saying goes.As long as human kidney is strong, each organ channels and collaterals all can be corresponding strong, and final people knows from experience more healthy, and the ability of resist the disease strengthens greatly.
The instructions of taking of sea cucumber, still take tonic as main at present, and tonic causes human absorptivity not enough, and the taboo of some culinary arts also usually causes the loss of sea cucumber nutrient composition, as, sea cucumber can not be cooked flavouring with vinegar.Therefore, there are on the market some sea cucumber deep processed products, as oral liquid, tablet, capsule, honey refining pill etc., in the process of deep processing, often adds Chinese patent drug to improve the absorptivity of product or to increase other auxiliary functions, but, some formula is unreasonable, for example, sea cucumber can not with Radix Glycyrrhizae compatibility etc.Therefore, it is simple that the present invention aims to provide a kind of manufacture method, and the product proportioning making is simple, and prescription collocation is reasonable, balance the body function, and hypotensive, hypoglycemic, lipid-lowering effect is good, strengthens the manufacture method of a kind of hypoglycemic holothurian oral liquid of body immunity.
summary of the invention:
The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of manufacture method simple, the product proportioning making is simple, prescription collocation rationally, balance the body function, hypotensive, hypoglycemic, lipid-lowering effect is good, strengthens the manufacture method of a kind of hypoglycemic holothurian oral liquid of body immunity.
To achieve these goals, the invention provides a kind of hypoglycemic holothurian oral liquid, wherein, comprise according to the following active component of parts by weight configuration:
Corn stigma 30-50 part, radix achyranthis bidentatae 20-40 part, tuber of multiflower knotweed 20-40 part, coptis 20-40 part, numb benevolence 10-30 part, tea root 10-30 part, parasitic loranthus 10-30 part, Radix Angelicae Sinensis 10-30 part, ginkgo leaf 10-30 part, Phytolacca acinosa 10-30 part, Herba Andrographitis 10-30 part, cornu bubali 10-30 part, leech 10-30 part, Ligusticum wallichii 10-30 part, sea cucumber 300-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Corn stigma 30-40 part, radix achyranthis bidentatae 20-30 part, tuber of multiflower knotweed 20-30 part, coptis 20-30 part, numb benevolence 10-20 part, tea root 10-20 part, parasitic loranthus 10-20 part, Radix Angelicae Sinensis 10-20 part, ginkgo leaf 10-20 part, Phytolacca acinosa 10-20 part, Herba Andrographitis 10-20 part, cornu bubali 10-20 part, leech 10-20 part, Ligusticum wallichii 10-20 part, sea cucumber 300-400 part.
Or, comprise according to the following active component of parts by weight configuration:
Corn stigma 40-50 part, radix achyranthis bidentatae 30-40 part, tuber of multiflower knotweed 30-40 part, coptis 30-40 part, numb benevolence 20-30 part, tea root 20-30 part, parasitic loranthus 20-30 part, Radix Angelicae Sinensis 20-30 part, ginkgo leaf 20-30 part, Phytolacca acinosa 20-30 part, Herba Andrographitis 20-30 part, cornu bubali 20-30 part, leech 20-30 part, Ligusticum wallichii 20-30 part, sea cucumber 400-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Corn stigma 35-45 part, radix achyranthis bidentatae 25-35 part, tuber of multiflower knotweed 25-35 part, coptis 25-35 part, numb benevolence 15-25 part, tea root 15-25 part, parasitic loranthus 15-25 part, Radix Angelicae Sinensis 15-25 part, ginkgo leaf 15-25 part, Phytolacca acinosa 15-25 part, Herba Andrographitis 15-25 part, cornu bubali 15-25 part, leech 15-25 part, Ligusticum wallichii 15-25 part, sea cucumber 350-450 part.
Object to better implement the present invention, the present invention discloses again a kind of manufacture method of hypoglycemic holothurian oral liquid, wherein, comprises the steps:
Get the raw materials ready:
Traditional Chinese medicinal components: corn stigma, radix achyranthis bidentatae, the tuber of multiflower knotweed, the coptis, numb benevolence, tea root, parasitic loranthus, Radix Angelicae Sinensis, ginkgo leaf, Phytolacca acinosa, Herba Andrographitis, cornu bubali, leech, Ligusticum wallichii;
Sea cucumber: 10 times of the parts by weight that the parts by weight of sea cucumber are corn stigma;
The step of A, cleaning: by corn stigma, radix achyranthis bidentatae, the tuber of multiflower knotweed, the coptis, fiber crops benevolence, tea root, parasitic loranthus, Radix Angelicae Sinensis, ginkgo leaf, Phytolacca acinosa, Herba Andrographitis, cornu bubali, leech, Ligusticum wallichii, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and for abstraction process creates conditions, soak time is 30-60min;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
Advantage of the present invention is: proportioning is simple, and prescription collocation is reasonable, balance the body function, and hypotensive, hypoglycemic, lipid-lowering effect is good, strengthens body immunity, is specially:
In sea cucumber extract, mix traditional Chinese medicine liquid and formed oral liquid of the present invention, oral liquid have taking dose little, absorb the advantages such as very fast, steady quality, easy to carry and use, easy preservation, be especially applicable to suitability for industrialized production.The present invention is to hypotensive, reducing blood lipid, and blood sugar decreasing effect is remarkable, can significantly improve body immunity, and by independent beche-de-mer or take more separately herb liquid, effect is all significantly increased.
the specific embodiment:
Hypoglycemic holothurian oral liquid of the present invention, wherein, comprises according to the following active component of parts by weight configuration:
Corn stigma 30-50 part, radix achyranthis bidentatae 20-40 part, tuber of multiflower knotweed 20-40 part, coptis 20-40 part, numb benevolence 10-30 part, tea root 10-30 part, parasitic loranthus 10-30 part, Radix Angelicae Sinensis 10-30 part, ginkgo leaf 10-30 part, Phytolacca acinosa 10-30 part, Herba Andrographitis 10-30 part, cornu bubali 10-30 part, leech 10-30 part, Ligusticum wallichii 10-30 part, sea cucumber 300-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Corn stigma 30-40 part, radix achyranthis bidentatae 20-30 part, tuber of multiflower knotweed 20-30 part, coptis 20-30 part, numb benevolence 10-20 part, tea root 10-20 part, parasitic loranthus 10-20 part, Radix Angelicae Sinensis 10-20 part, ginkgo leaf 10-20 part, Phytolacca acinosa 10-20 part, Herba Andrographitis 10-20 part, cornu bubali 10-20 part, leech 10-20 part, Ligusticum wallichii 10-20 part, sea cucumber 300-400 part.
Or, comprise according to the following active component of parts by weight configuration:
Corn stigma 40-50 part, radix achyranthis bidentatae 30-40 part, tuber of multiflower knotweed 30-40 part, coptis 30-40 part, numb benevolence 20-30 part, tea root 20-30 part, parasitic loranthus 20-30 part, Radix Angelicae Sinensis 20-30 part, ginkgo leaf 20-30 part, Phytolacca acinosa 20-30 part, Herba Andrographitis 20-30 part, cornu bubali 20-30 part, leech 20-30 part, Ligusticum wallichii 20-30 part, sea cucumber 400-500 part.
Or, comprise according to the following active component of parts by weight configuration:
Corn stigma 35-45 part, radix achyranthis bidentatae 25-35 part, tuber of multiflower knotweed 25-35 part, coptis 25-35 part, numb benevolence 15-25 part, tea root 15-25 part, parasitic loranthus 15-25 part, Radix Angelicae Sinensis 15-25 part, ginkgo leaf 15-25 part, Phytolacca acinosa 15-25 part, Herba Andrographitis 15-25 part, cornu bubali 15-25 part, leech 15-25 part, Ligusticum wallichii 15-25 part, sea cucumber 350-450 part.
Object to better implement the present invention, the present invention discloses again a kind of manufacture method of hypoglycemic holothurian oral liquid, wherein, comprises the steps:
Get the raw materials ready:
Traditional Chinese medicinal components: corn stigma, radix achyranthis bidentatae, the tuber of multiflower knotweed, the coptis, numb benevolence, tea root, parasitic loranthus, Radix Angelicae Sinensis, ginkgo leaf, Phytolacca acinosa, Herba Andrographitis, cornu bubali, leech, Ligusticum wallichii;
Sea cucumber: 10 times of the parts by weight that the parts by weight of sea cucumber are corn stigma;
The step of A, cleaning: by corn stigma, radix achyranthis bidentatae, the tuber of multiflower knotweed, the coptis, fiber crops benevolence, tea root, parasitic loranthus, Radix Angelicae Sinensis, ginkgo leaf, Phytolacca acinosa, Herba Andrographitis, cornu bubali, leech, Ligusticum wallichii, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and for abstraction process creates conditions, soak time is 30-60min;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
Object lesson 1
50 parts of corn stigmas, 40 parts of radix achyranthis bidentataes, 40 parts of the tubers of multiflower knotweed, 40 parts of the coptiss, 30 parts of numb benevolence, 30 parts of tea roots, 30 parts of parasitic loranthus, 30 parts of Radix Angelicae Sinensis, 30 parts of ginkgo leaves, 30 parts of Phytolacca acinosas, 30 parts of Herba Andrographitis, 30 parts of cornu bubalis, 30 parts of leech, 30 parts of Ligusticum wallichiis, 500 parts of sea cucumbers.
The step of A, cleaning: by corn stigma, radix achyranthis bidentatae, the tuber of multiflower knotweed, the coptis, fiber crops benevolence, tea root, parasitic loranthus, Radix Angelicae Sinensis, ginkgo leaf, Phytolacca acinosa, Herba Andrographitis, cornu bubali, leech, Ligusticum wallichii, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
Example 2
30 parts of corn stigmas, 20 parts of radix achyranthis bidentataes, 20 parts of the tubers of multiflower knotweed, 20 parts of the coptiss, 10 parts of numb benevolence, 10 parts of tea roots, 10 parts of parasitic loranthus, 10 parts of Radix Angelicae Sinensis, 10 parts of ginkgo leaves, 10 parts of Phytolacca acinosas, 10 parts of Herba Andrographitis, 10 parts of cornu bubalis, 10 parts of leech, 10 parts of Ligusticum wallichiis, 300 parts of sea cucumbers.
The step of A, cleaning: by corn stigma, radix achyranthis bidentatae, the tuber of multiflower knotweed, the coptis, fiber crops benevolence, tea root, parasitic loranthus, Radix Angelicae Sinensis, ginkgo leaf, Phytolacca acinosa, Herba Andrographitis, cornu bubali, leech, Ligusticum wallichii, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
Example 3
40 parts of corn stigmas, 30 parts of radix achyranthis bidentataes, 30 parts of the tubers of multiflower knotweed, 30 parts of the coptiss, 20 parts of numb benevolence, 20 parts of tea roots, 20 parts of parasitic loranthus, 20 parts of Radix Angelicae Sinensis, 20 parts of ginkgo leaves, 20 parts of Phytolacca acinosas, 20 parts of Herba Andrographitis, 20 parts of cornu bubalis, 20 parts of leech, 20 parts of Ligusticum wallichiis, 400 parts of sea cucumbers.
The step of A, cleaning: by corn stigma, radix achyranthis bidentatae, the tuber of multiflower knotweed, the coptis, fiber crops benevolence, tea root, parasitic loranthus, Radix Angelicae Sinensis, ginkgo leaf, Phytolacca acinosa, Herba Andrographitis, cornu bubali, leech, Ligusticum wallichii, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, for abstraction process creates conditions;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract.
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
Data comparison:
By step e gained traditional Chinese medicine liquid, three high crowd 50 people take, as A group,
By step F gained sea cucumber extract, three high crowd 50 people take, as B group
Three high crowd 50 people take traditional traditional blood sugar reducing holothurian oral liquid, and for example " the disclosed oral liquid of patent application 201210420808.6 " as C group,
Three high crowd's 50 people's beche-de-mers, one for each person every day, as D group.
Embodiment 1 takes for three high crowd 50 people, as E group.
Embodiment 2 takes for three high crowd 50 people, as F group.
Embodiment 3 takes for three high crowd 50 people, as G group.
Take continuously after 50 days, each one body status data is as follows: (people's health index mainly comprises the indexes such as body temperature, blood pressure, blood sugar, blood viscosity, blood fat, heart rate, and normal person's index is:
Body temperature, adult's body temperature temperature is 36.5-37 degree (oxter).
Blood pressure, adult's blood pressure should be systolic pressure 90-140 mercury column, diastolic pressure 60-90 mercury column.
Blood sugar, fasting blood-glucose normal value is below 6.1 or 109 milligrams, the normal value of blood sugar is below 7.8 or 140 milligrams after meal.
Blood viscosity is the abbreviation of blood viscosity, it is one of index of reflection viscosity of blood, the factor that affects blood viscousness mainly contains erythrocyte aggregation and morphotropism, packed cell volume, size and geometric, Blood Cholesterol, triglycerides and fibrinogenic content etc.
Blood fat, the lipid material in blood plasma is called blood fat, comprises triglycerides, phosphatide, cholesterol, cholesteryl ester and non-esterified fatty acid etc.
Heart rate, about 60-80 time of general adult's heartbeat per minute, average out to 75 times, children's heart rate is very fast.Pulse, is grown up 60-70 time per minute.Breathe the breathing per minute 14-18 time of being grown up)
Immunity comparison
Select 10 small white mouse feeding traditional blood sugar reducing holothurian oral liquids as a control group,
Select 10 small white mouse feedings the present invention group as a comparison.
Be compared as follows:
Wherein, the absorption of comparative group calcium and mineral matter is fast, and propagation Bifidobacterium, lactic acid bacteria number is many, and the index of blood fat, blood sugar, adjusting cholesterol is low compared with control group.3-5 is placed in dark environment and the environment that is exposed to the sun repeatedly in day, the control group probability of catching an illness is large, so comparative group immunity is strong.Manufacture method of the present invention is simple, and the product proportioning making is simple, and prescription collocation is reasonable, balance the body function, and hypotensive, hypoglycemic, lipid-lowering effect is good, strengthens body immunity.Be specially:
In sea cucumber extract, mix traditional Chinese medicine liquid and formed oral liquid of the present invention, oral liquid have taking dose little, absorb the advantages such as very fast, steady quality, easy to carry and use, easy preservation, be especially applicable to suitability for industrialized production.The present invention is to hypotensive, reducing blood lipid, and blood sugar decreasing effect is remarkable, can significantly improve body immunity, and by independent beche-de-mer or take more separately herb liquid, effect is all significantly increased.
Claims (1)
1. a manufacture method for hypoglycemic holothurian oral liquid, is characterized in that, comprises the steps:
Get the raw materials ready:
Traditional Chinese medicinal components: corn stigma, radix achyranthis bidentatae, the tuber of multiflower knotweed, the coptis, numb benevolence, tea root, parasitic loranthus, Radix Angelicae Sinensis, ginkgo leaf, Phytolacca acinosa, Herba Andrographitis, cornu bubali, leech, Ligusticum wallichii;
Sea cucumber: 10 times of the parts by weight that the parts by weight of sea cucumber are corn stigma;
The step of A, cleaning: by corn stigma, radix achyranthis bidentatae, the tuber of multiflower knotweed, the coptis, fiber crops benevolence, tea root, parasitic loranthus, Radix Angelicae Sinensis, ginkgo leaf, Phytolacca acinosa, Herba Andrographitis, cornu bubali, leech, Ligusticum wallichii, according to medicinal part: root, stem, piece, leaf, sheet are classified, clean respectively, use tumbling-box type medicine-washing machine to clean, the cleaning rotating speed that the root of take is used as medicine is 100 revs/min, stem, piece, leaf, sheet clean successively the rotating speed reduction by 5% of root and clean, and scavenging period is controlled at 3-5 minute, avoid drug effect to run off;
The step of B, demulcen: the traditional Chinese medicinal components that steps A is cleaned up, use water injection type medicine processing device to carry out demulcen operation, demulcen makes the plant cell imbibition of dehydration, and for abstraction process creates conditions, soak time is 30-60min;
The step of C, decoction: the sufficient traditional Chinese medicinal components of demulcen in step B is placed in to materials decoction device, extracts a not good liquor after heating decocts; Add again water and continue to decoct, extract two not good liquors; Add again water and continue to decoct, extract three not good liquors; By a not good liquor, two not good liquors, three not good liquors merge together, heat and concentrate, and obtain inspissated juice;
D, by step C gained inspissated juice, adding mass percent concentration is 95% ethanol, the amount adding is 10% of inspissated juice weight, to precipitate water-solubility impurity, adds additives, described additives are any one in flavouring, bacteriostatic agent, antioxidant or colouring agent, inspissated juice is uniformly dissolved, filters, use plate and frame filter press, millipore filter to filter, obtain filtrate
E, step D filtrate is heated, according to the different principle of boiling point, from filtrate, filtering ethanol and additives, obtain traditional Chinese medicine liquid, again after centrifugal filtration, embedding in tank body, sterilizing;
The step of F, sea cucumber deep processing: fresh and alive sea cucumbers, along belly from first to last complete section open, gill, impurity is cleaned up; Then carry out freeze drying, cryogenic temperature is-20 ~-25 ℃, and vacuum is 5-15Pa, and snap frozen 2-3h puts into pulverizer by the sea cucumber after freeze drying, pulverizes 10-30min, crosses 60 mesh sieves, obtains thick sea cucumber powder; Sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, and time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
In container, add pure water, sea cucumber powder after nanometer is pulverized with water with 1: the dissolving of 5-10 mass ratio, obtain sea cucumber milk, take the compound protease of sea cucumber weight 0.3-0.4%, compound protease is the mixture of pepsic bromelain stomach, protease: the mass ratio=2:1 of bromelain, after using pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000w in intensity, carry out the operation of microwave enzymolysis, after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out, complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature, enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid, enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters, and obtains filtrate, by filtrate by nanofiltration with except freshen, residue is crossed 100 mesh sieves, obtains sea cucumber extract,
G, filling step: step e gained herb liquid is mixed according to mass ratio 1-1.5:1-2 with step F gained sea cucumber extract, centrifugal filtration again, and sterilizing, the method that sterilizing adopts pasteurization to combine with microwave sterilization, filling after sterilizing, after filling and capping, 80-90 degree Celsius of sterilizing shifted out for 15 seconds.
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| CN104893933A (en) * | 2015-06-30 | 2015-09-09 | 青岛浩大海洋保健食品有限公司 | Bushen Zhuangyang Beishen compound wine |
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