CN106138968A - Integration of edible and medicinal herbs compositions of the intestines and stomach reparation and protection gastrointestinal mucosa and preparation method thereof - Google Patents
Integration of edible and medicinal herbs compositions of the intestines and stomach reparation and protection gastrointestinal mucosa and preparation method thereof Download PDFInfo
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- CN106138968A CN106138968A CN201610633177.4A CN201610633177A CN106138968A CN 106138968 A CN106138968 A CN 106138968A CN 201610633177 A CN201610633177 A CN 201610633177A CN 106138968 A CN106138968 A CN 106138968A
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Abstract
The invention provides a kind of for the intestines and stomach reparation and protection gastrointestinal mucosa integration of edible and medicinal herbs compositions; mainly prepared by following raw material: in terms of mass fraction, Radix Panacis Quinquefolii 4.5 11 parts, Fructus Lycii 37 parts; 2.5 6 parts of Fructus Jujubae; the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 10 parts, Fructus Crataegi 3.5 6 parts, Fructus Aurantii Immaturus 4.5 11 parts; 2 5.5 parts of Fructus Hordei Germinatus; 15 parts of Poria, Fructus Amomi 26 parts, Fructus Evodiae 0.5 4 parts.After preparation method includes all raw materials are picked, cleaned, through irradiation, pulverize, be dried and the step of the mixed grinding powdery that becomes mesh granularity to be more than 80 mesh, prepare tablet or capsule,.The integration of edible and medicinal herbs compositions for the intestines and stomach reparation and protection gastrointestinal mucosa that the present invention provides assembles simply; raw material is easy to get; in addition to the functions such as conventional increase gastric motility, warming the stomach, antiinflammatory, pain relieving; also there is the increase reparation of mucosa, regeneration, recover effect of normal gastrointestinal mucosa and function thereof.
Description
Technical field
The present invention relates to integration of edible and medicinal herbs compositions preparation field, in particular to one for the intestines and stomach reparation and protection
Integration of edible and medicinal herbs compositions of gastrointestinal mucosa and preparation method thereof.
Background technology
Owing to present social competition is the fiercest, people's rhythm of life is accelerated, and stress strengthens, and adds that environment is day by day
Deteriorating, the mankind are constantly in sub-health state, usually can induce the generation of various disease.Working people's all day pair especially now
Computer, three meals in a day are carried out by point the most on time, and health can be caused in the course of time various diseases, especially gastroenteropathy occur,
Light then often there will be symptoms such as repeatedly having a stomach-ache, heavy then the mucosa problems such as gastritis, ulcer, erosion and atrophy can be developed into, during outbreak
Gnawing pains take no rest, has a strong impact on normal work and life.
In prior art, the major product for gastroenteropathy has the medicine such as SANJIU WEITAI, sunflower WEIKANGLING on the market, these
Medicine is Chinese medicine extraction preparation, and ingredient is on the high side, and a lot of composition side effect are bigger, and are not suitable for long-term taking, and
Existing on the market for the Main Function of the product of gastroenteropathy simple concentrate on the merits such as increase gastric motility, warming the stomach, antiinflammatory, pain relieving
Can, relativity is more single, protects stomach aspect active force for guarantor's stomach relatively weak, limits its value applied further.
In view of this, the special proposition present invention.
Summary of the invention
The first object of the present invention is to provide a kind of integration of edible and medicinal herbs combination for the intestines and stomach reparation and protection gastrointestinal mucosa
Thing, said composition assembles simply, and raw material is easy to get, in addition to the functions such as conventional increase gastric motility, warming the stomach, antiinflammatory, pain relieving, also
Having the increase reparation of mucosa, regeneration, recover effect of normal gastrointestinal mucosa and function thereof, effect is relatively more comprehensive, and effect is non-
The most prominent, so that the person is more healthy, life lengthening.
The second object of the present invention is to provide the above-mentioned integration of edible and medicinal herbs combination for the intestines and stomach reparation and protection gastrointestinal mucosa
The preparation method of thing, preparation method has the advantage of the active ingredient that can completely retain medicine, and has method and be simply prone to
Operation, the advantages such as operating condition is gentle, the product safety prepared has no side effect, and can relieved use.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
Embodiments provide a kind of for treating gastroenteropathy and the integration of edible and medicinal herbs compositions of protection gastrointestinal function,
Mainly prepared by following raw material: in terms of mass fraction, Radix Panacis Quinquefolii 4.5-11 part, Fructus Lycii 3-7 part, Fructus Jujubae 2.5-6 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10
Part, Fructus Crataegi 3.5-6 part, Fructus Aurantii Immaturus 4.5-11 part, Fructus Hordei Germinatus 2-5.5 part, Poria 1-5 part, Fructus Amomi 2-6 part, Fructus Evodiae 0.5-4 part.
Because the pressure of modern society own is very big, people the most do not focus on the maintenance of oneself, especially for working people head
Phase faces toward computer work, and cause eating three meals a day is carried out by point the most on time, and health can be caused in the course of time various diseases occur, especially
It is gastroenteropathy, the most often there will be symptoms such as repeatedly having a stomach-ache, heavy then can develop into the mucosas such as gastritis, ulcer, erosion and atrophy
Problem, during outbreak, gnawing pains take no rest, has a strong impact on normal work and life.The when that the general state of an illness not weighing, people the most do not give
Enough attention, only when developing into gastroenteropathy, ability is treated by taking various medicine, and Western medicine is secondary comparatively speaking to be made
With bigger, bigger to other dysfunction of human body while reaching to treat gastroenteropathy, therefore occur various when stomach
Most people can not selected and take Chinese medicine in good time, but the Chinese medicine product medicine such as the SANJIU WEITAI circulated on the market, sunflower WEIKANGLING
Thing composition is on the high side, and dispensing itself is more complicated, and a lot of composition side effect are bigger, and are not suitable for long-term taking, comes from effect
Saying that function is the most single, function is concentrated mainly on the aspects such as increase gastric motility, warming the stomach, antiinflammatory, pain relieving, protects stomach side for protecting stomach
Face active force is relatively weak, limits its value applied further.
In order to solve many technical problems present in prior art, the invention provides a kind of by fundamentally nursing one's health
Every the intestines and stomach function of human body, to reach for stomach discomfort and to protect stomach and protect the integration of edible and medicinal herbs compositions of stomach, very simultaneously
Perfectly overcome the technical problem appeared above, not only taking convenience, without any side effects, it is achieved that fundamentally extensive
Multiple normal many-sided function such as protection gastrointestinal mucosa and function aspect, body immunity etc. carries out the regulation of profound level, makes people
Health is more healthy, life lengthening, and comparitive study is notable.The most protected gastric mucosa of this product and kill helicobacter pylori simultaneously
Effect, the integration of edible and medicinal herbs compositions of the present invention can be taken as health product when the slightest sensation stomach discomfort
With, can reach the effect repairing gastrointestinal function after long-term taking, greatly reduce and develop into inflammation, ulcer, erosion and atrophy
Probability Deng mucosa problem.
In the present invention, Radix Panacis Quinquefolii is a kind of plant, is famous and precious top grade raw material, is again high-grade nourishing good merchantable brand.It contains
There are 16 kinds of trace element of needed by human and 17 kinds with upper amino acid and polysaccharide, polypeptide and multivitamin etc., have anticancer, anti-
Fatigue, anti-hypoxia, radioprotective, anti-ageing several functions of waiting for a long time, often take Radix Panacis Quinquefolii, can building body, life lengthening.At this
General addition in bright is 4.5-11 part, more excellent for 6-10 part, optimum for 8 parts, consumption can also be 5 parts, 9 parts or
10 parts etc..
Fructus Lycii sweet in the mouth, property is put down.Enter liver, kidney channel.There is nourishing kidney, lung moistening, tonifying liver, effect of improving eyesight.It is mainly used in Liver and kidney cloudy
Lose, soreness of the waist and knees, dizzy, dizzy, the disease such as cough due to consumptive disease.Fructus Lycii contains the battalion such as abundant carotene, vitamin A, B1, B2, C
Support element.General addition is 3-7 part, more excellent for 4-6 part, optimum for 5 parts, consumption can also be 3.5 parts, 4.5 parts or
Person 6.5 parts etc..
Fructus Jujubae has another name called Fructus Jujubae, dry Fructus Jujubae, Chinese date, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman
The symptoms such as people's hysteria.Antitumor, antioxidation, blood pressure lowering, cholesterol, hepatoprotective agent is had to improve the effects such as immunity.Typically add
Dosage is 2.5-6 part, more excellent for 3-5 part, and optimum for 4 parts, consumption can also be 3.5 parts, 4.5 parts or 5.5 parts etc..
Pseudobulbus Bletillae (Rhizoma Bletillae) bitter in the mouth, sweet and puckery, cold nature, enter lung meridian.There is hemostasis, the function of detumescence, can treat that raw skin ulcer is hemorrhage, carbuncle
Toxic swelling, ulcer, rhagadia manus et pedis.General addition is 5-10 part, more excellent for 6-9 part, and optimum for 8 parts, consumption can also be
5.5 parts, 7 parts or 9.5 parts etc..
Crataegolic acid is sweet, tepor.Enter spleen, stomach, Liver Channel.Help digestion long-pending, dissipating blood stasis blood, expelling tenia.There is promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis
Effect.It is mainly used in meat stagnation, stomach alkane distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain
Bitterly, the disease such as hyperlipidemia.General addition is 3.5-6 part, more excellent for 4.5-5.5 part, and optimum for 5 parts, consumption can also be 4
Part, 4.8 parts or 5.8 parts etc..
The micro-acid of Fructus Aurantii Immaturus bitter in the mouth, warm in nature, return spleen, stomach warp.There is dispelling the stagnated QI removing food stagnancy, the effect of scattered painful abdominal mass of reducing phlegm.It is mainly used in stagnating
Inside stop, feeling of fullness distending pain, weight after dysentery, the disease such as constipation.General addition is 4.5-11 part, more excellent for 6-10 part, optimum
For 8 parts, consumption can also be 5 parts, 7 parts or 9 parts etc..
Fructus Hordei Germinatus nature and flavor are sweet flat, and tool circulation of qi promoting helps digestion, spleen benefiting and stimulating the appetite, move back effect of breast relieving distension.Be suitable for food stagnation do not disappear, gastral cavity abdominal distention
Bitterly, the edible for patients such as insufficiency of the spleen lack of appetite, human milk silt, distending pain of the breast, women's ablactation.General addition is 2-5.5 part, and more excellent is
3-5 part, optimum for 4 parts, consumption can also be 2.5 parts, 3.5 parts or 4.5 parts etc..
Poria sweet in the mouth, light, property are put down, and are used as medicine and have promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach, effect of mind tranquilizing and the heart calming.Modern medicine study
Showing, Poria energy enhancing human body immunity function, the polysaccharide wherein contained has obvious antitumor and the liver protecting effect.Typically add
Dosage is 1-5 part, more excellent for 2-4 part, and optimum for 3 parts, consumption can also be 1.5 parts, 3.5 parts or 4.5 parts etc..
Fructus Amomi acrid in the mouth is warm in nature, returns spleen channel, stomach warp, kidney channel.There is removing dampness appetizing, warming spleen and stopping diarrha, antiabortive effect of regulating the flow of vital energy.Main
Turbid damp obstructing in middle-JIAO to be used for, the diseases such as gastral cavity painful abdominal mass is the most hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.General addition is
2-6 part, more excellent for 3-5 part, optimum for 4 parts, consumption can also be 2.5 parts, 3.5 parts or 5.5 parts etc..
Fructus Evodiae nature and flavor heat, taste is pungent, bitter, has toxicity somewhat, returns liver,kidney,spleen, stomach warp.There is preventing or arresting vomiting, antiulcer,
Stomach invigorating, analgesic effect.Fructus Evodiae can also antithrombus formation, inhibitory anti-virus, there is certain hepatoprotective effect.General addition
For 0.5-4 part, more excellent for 1-3 part, optimum for 2 parts, consumption can also be 0.8 part, 1.5 parts or 3.5 parts etc..
Noticeable be, the present invention for for the intestines and stomach reparation and the integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa
Prescription select and the addition of each component is all the more excellent consumption that inventor passes through creative experiments optimization, need this
Raw material is the most compatible a bit can be only achieved purpose evident in efficacy, although these raw materials belong to the common raw material in traditional Chinese medical science field, but
Can be used to the material thousands upon thousands that dispensing does the integration of edible and medicinal herbs compositions of the present invention, find great majority by consulting pertinent literature
The intestines and stomach coordinating, the medical material of health preserving are simply cured the symptoms, not the disease, and can only temporarily play the intestines and stomach coordinating, improve effect of immunity, but
Can not be lasting, compare and have dependency, for a long time from the point of view of effect the most comprehensive, it is impossible to fundamentally realize the intestines and stomach conditioning.The present invention discloses
Integration of edible and medicinal herbs compositions the most exactly solve these problems, the crowd for gastrointestinal upset not only has good specific aim,
Increase gastrointestinal motivity, anti-inflammatory analgetic, and gastric mucosa can also be protected, promote the reparative regeneration of gastric mucosa, it is achieved that fundamentally
Effect of stomach is protected in nourishing the stomach, without any side effects to human body, and fundamentally achieves the conditioning of the every function to human body, effect
Comprehensively, many-side can be taken into account.The appearance of this integration of edible and medicinal herbs formula, same for the medicine food for the intestines and stomach reparation and protection gastrointestinal mucosa
The relevant synthesis of source composition compensate for corresponding technological gap, provides for this integration of edible and medicinal herbs compositions of follow-up making and can refer to
Prescription and concrete consumption, there is certain reference value, should be widely promoted application.Own group of the prescription of the present invention simultaneously
Join simple, compared to the stomach medicine that formula in prior art is complicated, the whole prescription of the present invention only has trivial ten taste raw materials, drug effect
Main based on the first seven taste, rear three tastes are auxiliary, but have reached, by after Synergistic, effect that existing stomach medicine does not reaches completely,
Composition is natural, without any manual member, is the composite formula of a kind of integration of edible and medicinal herbs, and safety has no side effect, can be relieved
Use.
These composition of raw materials are all have to add, all when the integration of edible and medicinal herbs composite preparation carrying out the present invention synthesizes
Belonging to natural rare medical material, and the addition of each medical material is also in step increments trend, dosage presents certain regularity, no
Can arbitrarily add, in such as this 10 taste raw material front 7 kinds as primarily serving the major ingredient of drug effect, dosage is bigger, and follow-up
Fewer to Poria, Fructus Amomi and the Fructus Evodiae dosage of potentiation, it is suitable to control, and so could drug effect be performed to
Ultimate attainment, meet the rule of monarch, for wanting to onset as early as possible, the crowd of bitterness own will not be detested again, by this 10
Taste prescription mixes as most preferably according to each optimum consumption, the most rapid-action, and while for stomach discomfort also
The immunity of the energy own person of raising so that human body is more healthy.
The embodiment of the present invention except provide a kind of for the intestines and stomach reparation and protection gastrointestinal mucosa integration of edible and medicinal herbs compositions
Formula, additionally provide the most several preparation methoies of this integration of edible and medicinal herbs compositions, one of which comprises the steps:
After all raw materials are picked, are cleaned, through irradiation, pulverize, be dried and mixed grinding become mesh granularity be 80 mesh with
On the step of powdery, prepare tablet or capsule,.
This preparation method operation itself is fairly simple, also produces without any waste residue, the mesh granularity of grinding in operating process
Needs control more than 80 mesh, more excellent for 80-100 mesh so that it is powder body is more homogeneous thus drug effect can maximum benefit.In order to
Being easy to subsequent grinding operations, early stage the most also to control in certain mesh granularity when pulverizing, and the mesh granularity of pulverizing is preferably controlled in
More than 50 mesh, the convenient subsequent operation of such particle size range.
It addition, the raw material of all integration of edible and medicinal herbs compositionss preferably through picking, after the pretreatment operation such as cleaning, spoke to be carried out
According to operation, irradiation can reach to kill the effect of microorganism, anticorrosion sterilizing, and the temperature of irradiation is unsuitable too high, and general control exists
Between 50-60 DEG C, the highest effective ingredient that can destroy in raw material of temperature.
Baking temperature in the present invention and drying time are also required to control in suitable scope, and the temperature being dried controls
70-80 DEG C, the time being dried controls at 1-2h, and moisture is fully evaporated totally, more favorably through dried by the raw material ground to form
Make various dosage form in follow-up, and be more beneficial for the performance of follow-up drug effect.
Additionally, present invention also offers a kind of for the intestines and stomach reparation and the system of integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa
Preparation Method, specifically includes following steps:
After all raw material irradiation, take Radix Panacis Quinquefolii, Fructus Lycii, Fructus Jujubae, Poria, Fructus Amomi and Fructus Evodiae and soak 1-2h, add water
Decocting, filtration residue collects concentration of liquid medicine, and fill becomes oral liquid；
By remaining raw material pulverizing, it is dried and the step of the mixed grinding powdery that becomes mesh granularity to be more than 80 mesh, prepares
Tablet or capsule are for jointly taking with described oral liquid.
This preparation method makes drug effect fully be refined out by the way of decocting, concentrating, sending out relative to drug effect
Waving also is a kind of ratio more preferably method, so that the drug effect of the various components in raw material can fully be dissolved into concentrated solution
In, first to soak a period of time before decocting, the time of immersion is 1-2min, then boiling, and general amount of water is
8-10 times of these raw material gross masses of Radix Panacis Quinquefolii, Fructus Lycii, Fructus Jujubae, Poria, Fructus Amomi and Fructus Evodiae, too much or the most not
Being beneficial to the performance of drug effect, the time of boiling is preferably controlled between 5-6h.
In order to fully be extracted by the effective ingredient in raw material, the step of medicinal liquid is collected in boiling successively, filtration residue
Repeat 2-3 time the most back and forth, medicinal residues can be fully utilized after being so repeated.
During concentration, after being condensed into the thick paste that relative density controls between 1.10-1.15, fill becomes oral liquid, such
Being more beneficial for the absorption of human body in the range of relative density, relative density is more excellent to be controlled between 1.12-1.14.
It should also be noted that various raw materials to select optimal processing mode, such as the West according to respective character
Ginseng, Fructus Lycii, Fructus Jujubae, Poria, Fructus Amomi and Fructus Evodiae ratio are well suited to decoct and are fully extract by effective ingredient therein, residue
Four kinds of raw materials then relative to the refinement using the mode directly ground to be more conducive to effective ingredient, therefore inventor is designing whole system
Also having during standby process route and sufficiently consider, former preparation method operational approach is simple, and the product form prepared is more
Being beneficial to carry, although latter preparation method operating process is the most loaded down with trivial details, but the tablet prepared or capsule are for described
Oral liquid cooperates and takes, and drug effect more preferably, can carry out unrestricted choice according to the actual requirements during application and prepare.
Finally, also include after concentration that cold preservation stands the step of more than 24h, after also fill becomes oral liquid, also include 100-
The step of sterilizing 30-40min under conditions of 120 DEG C, and through leak detection, lamp inspection, labeling vanning, obtain finished product, oral liquid is general
Specification fill with 10ml/ bottle.
The integration of edible and medicinal herbs compositions eating method of the present invention is very simple, in 10-30min (medicine) being taken before meal use ante cibum every day, and one
Day takes 2-3 time, and each one bottle of (10ml) oral liquid is equipped with 1-2 seed lac capsule or tablet, or 2-3 seed lac capsule or tablet every time,
Often adhere to taking can building body, life lengthening, nourishing the stomach is protected stomach, is reached the purpose of health care.
Product of the prior art mostly is Chinese medicinal material extract, and extraction process can lose product effective ingredient, destroys finished product
The restriction of effect own and balance, the processing technology of the present invention has then been accomplished absolute pure natural, has not been used modern complicated processing work
Skill, retains traditional fabrication mode, simultaneously without any manual member, in the hope of the optimum efficiency of retained product formula.
Compared with prior art, the invention have the benefit that
(1) the invention provides a kind of for the intestines and stomach reparation and protection gastrointestinal mucosa integration of edible and medicinal herbs compositions, not only group
Joining simple, raw material is easy to get, and the property of medicine is gentle, in addition to the functions such as conventional increase gastric motility, warming the stomach, antiinflammatory, pain relieving, also has
Increasing the reparation of mucosa, regeneration, recover effect of normal gastrointestinal mucosa and function thereof, effect is relatively more comprehensive, and effect is the most prominent
Go out, so that the person is more healthy, life lengthening；
(2) the integration of edible and medicinal herbs compositions of the present invention can also effectively nurse one's health the every function of human body, and tool improves and exempts from
Epidemic disease power, effect of building body, effect is notable, and additionally the product of the present invention is the natural Chinese herbal medicine drawn materials, and has no side effect,
Can reduce the ammonia nitrogen discharge etc. to environment after using, reduce environmental pollution, to the mankind and environmentally friendly, environmental protection；
(3) although the preparation method technics comparing of the present invention is simple, but Operating parameters needs strictly control, overturns
Traditional method simply boiled, not only before and after step linking closely, and each operating parameter is all valid control
In suitable scope, still belong to pioneering in integration of edible and medicinal herbs this preparation method of compositions preparation field, be worth follow-up and use for reference application,
Provide the operation measure referred to.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will
Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be
Can be by the commercially available conventional products bought and obtain.
Embodiment 1
As follows for the preparation method of the intestines and stomach reparation and the integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa:
1) each raw material is weighed by following quality: Radix Panacis Quinquefolii 4.5kg, Fructus Lycii 3kg, Fructus Jujubae 6kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 5kg, Fructus Crataegi 6kg, trifoliate orange
Real 4.5kg, Fructus Hordei Germinatus 5.5kg, Poria 1kg, Fructus Amomi 2kg, Fructus Evodiae 4kg；
2) above raw material picked, clean, after irradiation, after mixing is pulverized with pulverizer, stir, be dried, pulverizing (mesh
Granularity is more than 80 mesh), can grind several times again if the thickest, ground rear packaging makes capsule.
Embodiment 2
As follows for the preparation method of the intestines and stomach reparation and the integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa:
1) each raw material is weighed by following quality: Radix Panacis Quinquefolii 11kg, Fructus Lycii 7kg, Fructus Jujubae 2.5kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 10kg, Fructus Crataegi
3.5kg, Fructus Aurantii Immaturus 11kg, Fructus Hordei Germinatus 2kg, Poria 5kg, Fructus Amomi 6kg, Fructus Evodiae 0.5kg；
2) after above raw material being picked, is cleaned, 50-60 DEG C of irradiation, mixing pulverizer is ground into the powdery of more than 50 mesh,
Stir, 70-80 DEG C of dry 1-2h, pulverizing (mesh granularity is between 80-100 mesh), if relatively thicker can grind again several
Secondary, ground rear packaging makes tablet.
Embodiment 3
As follows for the preparation method of the intestines and stomach reparation and the integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa:
1) each raw material is weighed by following quality: Radix Panacis Quinquefolii 6kg, Fructus Lycii 4kg, Fructus Jujubae 3kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 6kg, Fructus Crataegi 5.5kg, trifoliate orange
Real 10kg, Fructus Hordei Germinatus 5kg, Poria 4kg, Fructus Amomi 5kg, Fructus Evodiae 3kg；
2) after above raw material being picked, is cleaned, 50-60 DEG C of irradiation, take Radix Panacis Quinquefolii, Fructus Lycii, Fructus Jujubae, Poria, Fructus Amomi and
Fructus Evodiae soaks 1-2h, adds the soak by water of 8-10 times, and filtration residue collects concentration of liquid medicine, and fill becomes oral liquid；
3) by the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Crataegi, Fructus Aurantii Immaturus, Fructus Hordei Germinatus and Fructus Hordei Germinatus co-grinding, (mesh granularity is for 70-80 DEG C of dry 1-2h, pulverizing
On 80 mesh), can grind several times again if relatively thicker, ground after packaging make tablet, follow-up when taking with above
Oral liquid with the use of.
Embodiment 4
As follows for the preparation method of the intestines and stomach reparation and the integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa:
1) each raw material is weighed by following quality: Radix Panacis Quinquefolii 10kg, Fructus Lycii 6kg, Fructus Jujubae 5kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 9kg, Fructus Crataegi 4.5kg,
Fructus Aurantii Immaturus 6kg, Fructus Hordei Germinatus 3kg, Poria 2kg, Fructus Amomi 3kg, Fructus Evodiae 1kg；
2) after above raw material being picked, is cleaned, 50-60 DEG C of irradiation, take Radix Panacis Quinquefolii, Fructus Lycii, Fructus Jujubae, Poria, Fructus Amomi and
Fructus Evodiae soaks 1-2h, adds the soak by water of 8-10 times, and it is left at 1.10-1.15 to relative density that filtration residue collects concentration of liquid medicine
The right side, cold preservation stands 24h, and fill becomes oral liquid, and specification is 10ml/ bottle, 100 DEG C of sterilizing 30min, leak detection, lamp inspection, and labeling is cased,
Obtain finished product；
3) by the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Crataegi, Fructus Aurantii Immaturus, Fructus Hordei Germinatus and Fructus Hordei Germinatus co-grinding, (mesh granularity is for 70-80 DEG C of dry 1-2h, pulverizing
On 80 mesh), can grind several times again if relatively thicker, ground after packaging make tablet, follow-up when taking with above
Oral liquid with the use of.
Embodiment 5
As follows for the preparation method of the intestines and stomach reparation and the integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa:
1) each raw material is weighed by following quality: Radix Panacis Quinquefolii 8kg, Fructus Lycii 5kg, Fructus Jujubae 4kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 8kg, Fructus Crataegi 5kg, Fructus Aurantii Immaturus
8kg, Fructus Hordei Germinatus 4kg, Poria 3kg, Fructus Amomi 4kg, Fructus Evodiae 2kg；
2) after above raw material being picked, is cleaned, 50-60 DEG C of irradiation, take Radix Panacis Quinquefolii, Fructus Lycii, Fructus Jujubae, Poria, Fructus Amomi and
Fructus Evodiae soaks 1-2h, adds the soak by water of 8-10 times, and it is left at 1.10-1.15 to relative density that filtration residue collects concentration of liquid medicine
The right side, cold preservation stands 30h, and fill becomes oral liquid, and specification is 10ml/ bottle, 120 DEG C of sterilizing 40min, leak detection, lamp inspection, and labeling is cased,
Obtain finished product；
3) by the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Crataegi, Fructus Aurantii Immaturus, Fructus Hordei Germinatus and Fructus Hordei Germinatus co-grinding, (mesh granularity is for 70-80 DEG C of dry 1-2h, pulverizing
On 80 mesh), can grind several times again if relatively thicker, ground after packaging make tablet, follow-up when taking with above
Oral liquid with the use of.
Experimental example 1
By the integration of edible and medicinal herbs compositions of the embodiment of the present invention 1 Kunming mouse Oral toxicity to two kinds of sexes, ld > 10g/
Mono-week interior animal of kg.bw has no obvious poisoning symptom, also without animal dead.By acute toxicity classification, the true border of this tested material without
Poison level class material.Three mutagenicity tests (mice bone marrow micronucleus, mouse inbred strain, ames
Test) result is feminine gender.Within 30 days, feeding trial shows: this tested material 0.19g+6.6ml, 0.37g+13.2ml, 0.56g+
19.8ml/kg.bw dosage (is equivalent to 20-60 times of crowd's recommended amounts 0.0093g+0.33ml/kg.bw), examines rat clinic
Look into the project measurement result such as (containing body weight and food utilization), blood, biochemistry, internal organs histopathology all without obvious toxicity shadow
Ring.Tertogenicity test result shows: wistar rat is bred by this tested material and tire Mus growth promoter, internal organs, bone marrow are all without substantially
Harmful effect, to wistar rat without teratogenesis.
It addition, the integration of edible and medicinal herbs compositions of the embodiment of the present invention 1 to be carried out acute toxicity testing, micronucleus test, mice essence
Son deformity experiment and ames test, specific experiment process is as follows:
Acute toxicity testing process: laboratory animal is Kunming mouse 18-20g, each 10 of male and female, take tested material liquid
90ml is configured to the solution containing 1% sodium carboxymethyl cellulose, and (capsule goes to add the integration of edible and medicinal herbs composition powder of embodiment 1
Shell) 20g is configured to suspension, by 0.3ml/10g.bw per os gavage, is spaced 3 hours gavages 2 times, and stop eating before gavage 16hr.Meter
Calculate twice gavage total amount, Continuous Observation one week, and record animal poisoning symptom and death condition.Result is as follows: without death condition,
Two treated animal performances without exception, thus in being concluded that one week, animal has no obvious poisoning symptom and dead generation, by acute poison
Property classification, the true border of this tested material nontoxic level class material.
Micronucleus test process: laboratory animal is Kunming mouse, 25-27g, and male and female have concurrently, tested material is prepared with acute poison
Property test.Animal is randomly divided into 6 groups by body weight, and a group is negative control group, and f group is cyclophosphamide positive controls, separately sets four
Test dose group.Experimental group dosage is respectively 5,2.5,1.3,0.7g/kg.bw.Twice gavage is spaced 24 hours, gavage for the second time
After 6 hours, putting to death animal, take bone marrow of sternum smear, giemsa dyes.Every animal oil Microscopic observation 1000 thin addicted to incarnadining more
Born of the same parents, result is as follows: each experimental group and negative control group results contrast, no significant difference, shows the integration of edible and medicinal herbs of this embodiment 1
The bone marrow micronucleus test result of compositions is negative.
Mouse inbred strain process: experimental animal is Kunming mouse, 23-25g, totally 35, animal by body weight with
Machine is divided into 5 groups, and a group is negative control group, and e group is cyclophosphamide positive controls, and b/c/d group is test group.Test group dosage
Be respectively 3.0,6.0,11.0g/kg.bw.Animal per os every day gavage 2 times, is spaced 35 hours, each 0.3ml/10g.bw, even
Continuous gavage, after five days, is further continued for feeding 30 days, puts to death animal, takes both sides epididymis smear, eosin stains.Under every animal high power lens
Observe 1000 sperms, record teratospermia number.
Conclusion: each experimental group and negative control group results contrast, no significant difference, shows that the medicine food of this embodiment 1 is same
Source composition is negative to sperm malformation test result.
Ames process of the test: use the identified Salmonella typhimurium histidine deficient meeting biological requirement
TA97, TA98, TA100, TA102 tetra-strain bacterial strain test, use Polychlorinated biphenyls (PCB) rat liver homogenate induced as body
Outer activation system.Both tested materials 1:1 is mixed into suspension, is divided into three dosage groups, and it is low dose group that stock solution dilutes 1000 times,
It is middle dosage group that stock solution dilutes 100 times, and it is high dose group that stock solution dilutes 10 times, 121 degrees Celsius, 20 minutes sterilization treatment, every ware
Addition is 0.5ml.Blank and positive controls are set simultaneously.Use the parallel sample knot that flat board incorporation methods record secondary repeats
Really.Conclusion: the integration of edible and medicinal herbs compositions of this embodiment 1 respectively organizes back change clump count all not less than certainly beaming back parameter 2 times, and without dosage
Reaction relation, therefore ames result of the test is negative.
Integration of edible and medicinal herbs compositions embodiment of the present invention 2-5 prepared carries out above-mentioned experiment and also obtains identical experiment
As a result, illustrate that the integration of edible and medicinal herbs compositions of the present invention is guaranteed on drug safety.
Experimental example 2
The integration of edible and medicinal herbs compositions embodiment of the present invention 2 prepared is as test-meal group, and WEIKANGLING as a control group, is subject to
Examination object choice be chronic superficial gastritis patient 61 example through gastroscope, the age 17-65 year, without systems such as severe cardiac Liver and kidney
Disease patient, is randomly divided into test-meal group and matched group, each group respectively 31,30 examples, wherein test-meal group, male 24 example, women 7 example,
Age 28-56 year；Matched group, male 20 example, women 10 example, age 28-56 year.Use control design between own control and group.
Test-meal group gives the integration of edible and medicinal herbs compositions that the embodiment of the present invention 2 prepares, and for every day twice, each oral liquid one adds glue
One, capsule, matched group gives WEIKANGLING, and for three times a day, each one wraps, and takes continuously 30 days, disables other treatment during test-meal
Gastropathy medicine or the health food of protection gastric mucosa.
Observation of symptoms: inquiry the examination medical history of trencherman, the course of disease, clinical symptoms in detail: gastralgia, belch, noisy pantothenic acid, abdomen
Swollen, appetite stimulator, limbs are weak and the symptom such as costalgia.By the weight classification (serious symptom 3 points, middle disease 2 points, mild 1 point) of symptom,
Add up symptom integral value before and after test-meal, and (each symptom improvement 2 is divided into effective, improves one and is divided into effectively) is improved with regard to cardinal symptom
Observe the symptoms improvement rate.Check body of the tongue, tongue fur, pulse condition etc., and observe gastric mucosa inflammation improvement situation.Gastric mucosa inflammation grade mark
Standard is: slight for inflammatory cell infiltration bottom gastric pits more than, moderate is that inflammatory cell infiltration is as deep as body of gland lamina propria, severe
For inflammatory cell infiltration as deep as muscularis mucosae.Pathologic lymph follicle volume relatively big (diameter is more than 250um), has in hair growth promoting in it
The heart, around has massive inflammatory cells infiltrated；Occur in outside muscularis mucosae, around have body of gland to destroy or disappear.Additionally also has blood
Conventional (RBC, WBC, HBG), liver function (ALT), renal function (BUN, CRE) and Electrocardioscopy；
Experimental result:
Effect criterion: symptom improves more than 2 grades, gastroscope display acute inflammation disappears substantially, and chronic inflammatory disease degree is good
It is effective for turning 1 degree；
Symptom improves more than 1 grade, and gastroscope display non-cancer lesion reduces more than 1/2nd, and Acute and chronic inflammation degree alleviates 1
Degree is effective；
Do not reach effective standard or on the contrary deterioration person for invalid；
61 examples tested with above-mentioned standard sight, find that in 31 examples of test-meal group, 20 examples are effective, and 11 examples are effectively, so
And in 30 examples of matched group, 10 examples are effectively, 20 examples are invalid, it is seen that although the WEIKANGLING group of matched group has improves clinical symptoms
Effect, but obvious not, the integration of edible and medicinal herbs compositions of the embodiment of the present invention in terms of the intestines and stomach reparation with protection gastric mucosa then
Having good effect, conventional stomach medicine product can not be compared on the market.
It addition, the integration of edible and medicinal herbs compositions embodiment of the present invention 1,3-5 prepared carries out above-mentioned experiment also obtains phase
Same experimental result, illustrates that integration of edible and medicinal herbs compositions effect in terms of the intestines and stomach reparation and protection the intestines and stomach of the present invention is more preferable.
Case 1
Mrs Ma, 58 years old, people from Kweiyang, Guizhou Province, makes a definite diagnosis middle severe atrophic gastritis accompanied intestinal, hypertrophy, every half a year for 2013
Gastroscopy once, fears canceration.Patient has serious constipation, sometimes stays out of external means, several days all cannot normal defecation,
Abdominal distention every day, pain simultaneously, back all pain time serious, regular meal can only eat again smaller part bowl noodles or medicated porridge, nearest half a year
Become thin a lot, but also the most weak, there is no spirit.
Taking the integration of edible and medicinal herbs compositions of the embodiment of the present invention 1 after about 15 days, abdominal distention alleviates, and does not the most use the external world
About means 2-3 days can normal defecation once.After taking medicine 30 days, abdominal distention alleviates further, basic about 1-2 days normal defecations one
Secondary, appetite comes, the amount of original 2 times can be eaten, people's progressively some spirit.Persistently taking about 4 months, abdominal distention does not has substantially
Having, pain disappears, and defecation is normal, has rosy cheeks, runs to fat more than 10 jin, goes to hospital to do gastroscopy, middle severe atrophic gastritis
Companion's intestinal, hypertrophy are changed into superficial gastritis, and follow-up is main to support.
Case 2
Mr. Zhang, 62 years old, people from Shandong, within 2009, it is diagnosed as erosive gastritis, the most continuous pain, abdominal distention, once in a while
Also acid regurgitation.First open the Western medicine such as omeprazole, motilium in hospital, had some the most better, do not eaten and just violate.Treated more than 3 years always,
It is showed no improvement.Taking the integration of edible and medicinal herbs compositions of the embodiment of the present invention 2 after 3 days, pain relief, after taking medicine 7 days, appetite increases
Adding, pain alleviates further, after taking medicine 20 days, pain frequency and degree be improved significantly, appetite increases, the spirit of people than with
Front good a lot.After taking medicine 60 days, the symptoms such as basic recovery is normal, and diet is normal, and pain is uncomfortable are wholly absent.Note drink below
Food, can return to one's perfect health under consolidating.
Case 3
Mr. Zhang, 36 years old, people from Hubei, within 1998, it is diagnosed as gastric and duodenal ulcers in local people hospital, mainly
Excessive drinking and bad life habits cause, and start not pay attention to its state of an illness, follow-up because occurring seriously having blood in stool, vomiting and dirarrhea, completely
Can not normally take food, to eat liquid food, people becomes thin substantially, can't take care of oneself, after be ready to hospital surgical, excise stomach.
Upon somebody's introduction, the prescription of the present invention is taken after.Take the integration of edible and medicinal herbs compositions of the embodiment of the present invention 5 within 7 days, to have blood in stool improvement, take
30 days, the situation of having blood in stool was substantially achieved control, and period is based on liquid food.After taking 60 days, complexion makes moderate progress, and strength increases, can
The most movable, diet appetite is significantly increased, and pain occurs once in a while, basic disappearance of having blood in stool.After taking 140 days, basic recovery is normal,
But it is main for also needing to recuperation, rear after treatment is main.
Case 4
Mr. Chen, 40 years old, people from Jing Dezhen, Jiangxi Province, within 2006, it is defined as chronic gastritis, gastric antrum portion at local Grade A hospital
Congested, edema.There are acid regurgitation, heartburn, abdominal distention at ordinary times, have the symptom of pain once in a while, start to eat a little Western medicine symptom and quickly alleviate, after
The effect that has Western medicine is the chronicest, and symptom is more and more obvious, under hospital advises, begins with the conditioning of this prescription.Take the present invention real
Executing the integration of edible and medicinal herbs compositions 10 days of example 5, effect is the most obvious, and early stage is taken too much due to patient's Western medicine, and health produces and resists
The property of medicine, effect embodies slow；After taking 30 days, heartburn, acid regurgitation disappears substantially, as long as it is typically no not eat the food such as sweet, sour
These symptoms, pain also has once in a while, and appetite is bigger than in the past, but somewhat eats multiple spot, eats food really up to the mark, and abdominal distention goes out the most once in a while
Existing；After taking 80 days, heartburn, acid regurgitation, abdominal distention, pain all disappear, and people has rosy cheeks, and strength increases.Follow-up be careful in one's diet with support
It is main.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims
Including all such changes and modifications belonged in the scope of the invention.
Claims (10)
1. the integration of edible and medicinal herbs compositions being used for the intestines and stomach reparation and protection gastrointestinal mucosa, it is characterised in that main by following former
Material prepares: in terms of mass fraction, Radix Panacis Quinquefolii 4.5-11 part, Fructus Lycii 3-7 part, Fructus Jujubae 2.5-6 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part, Fructus Crataegi 3.5-6
Part, Fructus Aurantii Immaturus 4.5-11 part, Fructus Hordei Germinatus 2-5.5 part, Poria 1-5 part, Fructus Amomi 2-6 part, Fructus Evodiae 0.5-4 part.
The most according to claim 1 for the intestines and stomach reparation and protection gastrointestinal mucosa integration of edible and medicinal herbs compositions, its feature exists
In, in terms of mass fraction, Radix Panacis Quinquefolii 6-10 part, Fructus Lycii 4-6 part, Fructus Jujubae 3-5 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 6-9 part, Fructus Crataegi 4.5-5.5 part, Fructus Aurantii Immaturus
6-10 part, Fructus Hordei Germinatus 3-5 part, Poria 2-4 part, Fructus Amomi 3-5 part, Fructus Evodiae 1-3 part.
The most according to claim 1 and 2 for the intestines and stomach reparation and protection gastrointestinal mucosa integration of edible and medicinal herbs compositions, its feature
It is, in terms of mass fraction, Radix Panacis Quinquefolii 8 parts, Fructus Lycii 5 parts, 4 parts of Fructus Jujubae, the Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Fructus Crataegi 5 parts, Fructus Aurantii Immaturus 8 parts, 4 parts of Fructus Hordei Germinatus,
3 parts of Poria, Fructus Amomi 4 parts, Fructus Evodiae 2 parts.
4. described in any one of claim 1-3 for the intestines and stomach reparation and the integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa, it is special
Levy and be, comprise the steps:
After all raw materials are picked, are cleaned, through irradiation, pulverize, be dried and mixed grinding become mesh granularity to be more than 80 mesh
The step of powdery, prepares tablet or capsule,.
The most according to claim 4 for the intestines and stomach reparation and the preparation side of integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa
Method, it is characterised in that the temperature of irradiation controls at 50-60 DEG C；
Preferably, the mesh Task-size Controlling of pulverizing is more than 50 mesh.
The most according to claim 4 for the intestines and stomach reparation and the preparation side of integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa
Method, it is characterised in that dry temperature controls at 70-80 DEG C, be dried time control at 1-2h；
Preferably, grinding to form mesh granularity is the powdery between 80-100 mesh.
7. described in any one of claim 1-3 for the intestines and stomach reparation and the preparation of integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa
Method, it is characterised in that comprise the steps:
After all raw material irradiation, take Radix Panacis Quinquefolii, Fructus Lycii, Fructus Jujubae, Poria, Fructus Amomi and Fructus Evodiae soak 1-2h, boiling,
Filtration residue collects concentration of liquid medicine, and fill becomes oral liquid；
By remaining raw material pulverizing, it is dried and the step of the mixed grinding powdery that becomes mesh granularity to be more than 80 mesh, prepares tablet
Or capsule is for jointly taking with described oral liquid.
The most according to claim 7 for the intestines and stomach reparation and the preparation side of integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa
Method, it is characterised in that the water rate control of immersion is at Radix Panacis Quinquefolii, Fructus Lycii, Fructus Jujubae, Poria, Fructus Amomi and the 8-of Fructus Evodiae gross mass
10 times；
Preferably, the time of boiling controls between 5-6h.
The most according to claim 7 for the intestines and stomach reparation and the preparation side of integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa
Method, it is characterised in that be concentrated into relative density and control, between 1.10-1.15, to be preferably controlled between 1.12-1.14.
The most according to claim 7 for the intestines and stomach reparation and the preparation side of integration of edible and medicinal herbs compositions of protection gastrointestinal mucosa
Method, it is characterised in that also include after concentration that cold preservation stands the step of more than 24h；
Preferably, the step of sterilizing 30-40min under conditions of 100-120 DEG C is also included after fill becomes oral liquid.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020113497A1 (en) * | 2018-12-06 | 2020-06-11 | 江苏安惠生物科技有限公司 | Health care capsule having laxative function |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1237454A (en) * | 1999-06-17 | 1999-12-08 | 李国民 | Health-care medicine with therapeutic action of curing gastropathy and its preparation method |
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2016
- 2016-08-04 CN CN201610633177.4A patent/CN106138968A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1237454A (en) * | 1999-06-17 | 1999-12-08 | 李国民 | Health-care medicine with therapeutic action of curing gastropathy and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 冯兴泗: "益胃汤治疗35例慢性胃炎小结", 《浙江中医学院学报》 * |
| 裘黎明: "活血化淤法在慢性萎缩性胃炎治疗中的运用", 《实用中医药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020113497A1 (en) * | 2018-12-06 | 2020-06-11 | 江苏安惠生物科技有限公司 | Health care capsule having laxative function |
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