CN102178934B - Preparation for increasing bone mineral density, preventing osteoarthrosis and enhancing immunity - Google Patents
Preparation for increasing bone mineral density, preventing osteoarthrosis and enhancing immunity Download PDFInfo
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- CN102178934B CN102178934B CN201110098758XA CN201110098758A CN102178934B CN 102178934 B CN102178934 B CN 102178934B CN 201110098758X A CN201110098758X A CN 201110098758XA CN 201110098758 A CN201110098758 A CN 201110098758A CN 102178934 B CN102178934 B CN 102178934B
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Abstract
The invention provides a health care food used for increasing bone mineral density, preventing osteoarthrosis and enhancing immunity. The health care food is prepared from the following materials in parts by mass: 1500-2500 parts of marine fish bone collagen oligopeptide, 1500-2500 parts of fish bone powder, 200-400 parts of eucommia bark extract and 0.005-0.01 part of vitamin D and a proper amount of pharmaceutic adjuvants such as xylitol, dry skim milk, vegetable fat powder, essences, trichlorosucrose and the like. The health care food is prepared into a granular preparation by the following process steps of: premixing, granulating, total mixing and the like. The invention has the beneficial effects that the raw materials, i.e., marine fish bone collagen oligopeptide and fish bone which contain a large quantity of peptide, bone collagen and calcium, work together with eucommia bark extract and vitamin D in the health care food so that a human body can absorb effective ingredients better to increase bone mineral density, slow down bone marrow aging, enhance toughness of bones, and prevent and treat osteoporosis; in addition, peptide also has the functions of adjusting immunity and resisting bacteria and oxidation, thereby improving the immunity of the human body.
Description
Technical field
The present invention relates to a kind of drug regimen prescription, be used for bone density improving, prevent and treat osteoarthritis and enhancing human body immunity power.
Background technology
Along with the aggravation of aged tendency of population, the number of suffering from osteoporosis, osteoarthritis and hypoimmunity is also increasing.Osteoporosis is to reduce with the bone amount, and the microstructure degeneration of bone is a characteristic, causes the fragility increase of bone and a kind of general skeletal diseases that is easy to fracture.The osteoporosis Epidemiological study shows; The generation of bone strength and fracture is relevant with bone mineral content, is the common disease of middle-aged and elderly people, can cause fracture to take place; Bringing very big misery and financial burden to patient, is the human second largest healthy killer who is only second to cardiovascular disease.Osteoarthritis is a kind of with local articular cartilage degeneration, bone loss, and marginal spurs formation and joint deformity and the densification of subchondral bone matter are the chronic joint disease of characteristic; Claim osteoarthritis again; Degenerative osteoarthritis, proliferative arthritis, senile arthritis.Good sending out in crowd more than 50 years old, the women is more than the male, the quality of life that influences middle-older patient in various degree.Immunity is human body identification " oneself " and a kind of physiological reaction ability of getting rid of " dissident ".If immune system can not normally be brought into play protective effect, very easily cause infection such as antibacterial, virus, fungus, human health in serious harm.Therefore it is very important to develop a kind of health food that helps bone density improving, enhancing immunity.
Summary of the invention
The present invention provides a kind of preparation that is used for bone density improving, prevents and treats osteoarthritis and enhancing immunity, is used for Prevention and Treatment of Osteoporosis, osteoarthritis and enhancing immunity.
The technical scheme that the present invention adopted is: adopting marine fishbone collagen oligopeptide powder, fishbone powder, Cortex Eucommiae extract, vitamin D is primary raw material; It is characterized in that it is by following quality proportioning: 1500～2500 parts of marine fishbone collagen oligopeptide powder, 1500～2500 parts of fishbone powder, 200～400 parts of Cortex Eucommiae extract, 0.005～0.01 part of vitamin D; Pharmaceutic adjuvant (like xylitol, skim milk, non-dairy creamer, essence, sucralose etc.) is an amount of, processes granule through premix, preparation of granules, total production technology such as mix.
Cortex Eucommiae extract is with after the Cortex Eucommiae drying and crushing, is to add 60% ethanol at 1: 10 by solid-liquid ratio, at microwave power 400W, under 80 ℃ of conditions, extracts 10min, back concentrating under reduced pressure drying and getting.
Of the present invention part is mass parts, is mass units such as this area microgram commonly used, milligram, gram, kilogram.
A preparation suggestion of the present invention day clothes effective dose is 5～8g, and every day 1 time, warm boiled water gets final product.
The invention has the beneficial effects as follows: contain a large amount of peptides, ossein and calcium in these article raw material marine fishbone collagen oligopeptide powder and the fishbone powder; Can make human body better absorb the effective ingredient in these article in conjunction with Cortex Eucommiae extract, vitamin D; Bone density improving slows down the bone marrow aging, reduces the generation of osteopathia; The wilfulness of enhances skeletal, Prevention and Treatment of Osteoporosis; Wherein peptide also has and regulates immune, antibiotic, antiviral, antioxidative function, is applicable to because of symptoms such as having a delicate constitution of causing of bone joint pain, health shortening, hunch that osteopathia causes, symptom and hypoimmunity such as be easy to fracture, listlessness, fatigue and weak, sleep disorder.Compound basis:
Marine fishbone collagen oligopeptide powder is to be the bone peptide series products of raw material extraction with the deep-sea fishbone, and molecular weight surpasses 85% less than 1000 peptide content.Have high biological safety, and very easily be absorbed by the body.
Be made up of 1/3 Organic substance and 2/3 inorganic matter in the osseous tissue, collagen protein occupies machine composition 80%-90%, and it is to keeping bone structure and characteristic is extremely important.Ossein content descends and the reduction of bone biomechanical intensity has rectilinear correlation property.Osteoporotic fracture descends relevant with ossein.U.S. FDA is reached a conclusion through research: hydrolytic collagen has potential therapeutical effect to osteoarthritis and osteoporosis, and taking for a long time is very safely and effectively.Collagen polypeptide can stimulate chondrocyte to synthesize collagen protein I I (collagen protein II is osteoarticular main basis), and can influence the conversion of collagen in osteoarthrosis, is a kind of potential therapeutant to osteoarthritis and osteoporosis.
Fishbone powder is to be formed through prepared such as drying, pulverizing by fishbone, and its calcium content is more than 20%.Calcium is the important nutrient and the main component that constitutes bone mineral of keeping bone health, and 99% of this total amount is stored in the skeleton in the body.And vitamin D is one of important calmodulin, and the conversion storage that absorbs of intestinal calcium absorption and calcium all be unable to do without vitamin D.According to preliminary survey China more than 60 years old the old people have 67% to be in the vitamin D deficiency state.Generally on the low side at present Chinese people average every day of calcium intake.At bone density improving, cortex thickness of bone, the effect of improving structural mechanics and material mechanical performance and anti-absorbability aspect is more obvious than simple calcium preparation for calcium vitaminize D.
The Cortex Eucommiae is the traditional rare Chinese medicine of China, in Shennong's Herbal, classifies top grade medical material as, has effects such as bone and muscle strengthening, invigorating the liver and kidney, beneficial waist knee joint, disacidify are painful, antiabortive gas.In the ancient books before more than 2,000 years, but just have eucommia bark to fry in shallow oil the record of soup drink-service enhance muscle, in long Chinese medicine developing history, people pay attention to the strengthening the tendons and bones, the liver and the kidney tonifying of the Cortex Eucommiae, effect such as antiabortive always.Research in recent years proves, the Cortex Eucommiae can promote in the skin, skeleton, muscle of human body protein collagen synthetic with decompose, have the promotion metabolism, prevent the function that fails.
Thereby more than each raw material these article of making that complement each other have good bone density improving, prevent the function of osteoarthritis and enhance immunity.
The function of said preparation:
One, enhance bone density, prevent and treat osteoarthritis
Contain abundant peptide and calcium in this invention preparation, but the synthetic collagen protein I I of effective stimulus chondrocyte, and can influence the conversion of collagen in osteoarthrosis; Combine vitamin D simultaneously, can enhances human body to absorption, utilization and the conversion of calcium; Thereby the content of calcium in the increase bone promotes osteocyte propagation, differentiation, bone density improving, the generation of prevention of osteoporosis.Collagen polypeptide has excellent prevention and therapeutical effect to various joint disease.
Two, enhance immunity, raising self-resistance
Contained effective ingredient bioactive peptide can be regulated immunity, antibiotic, antiviral, antioxidation in this invention preparation, and the enhances human body immunity improves self-resistance.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Below in conjunction with embodiment the present invention is done further description:
Embodiment 1: a kind of preparation that is used for bone density improving, prevents and treats osteoarthritis and enhancing immunity; Adopting marine fishbone collagen oligopeptide powder, fishbone powder, Cortex Eucommiae extract, vitamin D is primary raw material; By following quality proportioning: marine fishbone collagen oligopeptide powder 2000g, fishbone powder 2000g, Cortex Eucommiae extract 300g, vitamin D 0.005g; Process granule in conjunction with adjuvant xylitol 1000g, skim milk 250g, non-dairy creamer 250g, Fructus Vins sugar essence 200g, sucralose 6g through premix, preparation of granules, total production technology such as mix, adorn every bag of 6g, every day 1 time; Each one bag, use warm boiled water.
Embodiment 2: a kind of preparation that is used for bone density improving, prevents and treats osteoarthritis and enhancing immunity; Adopting marine fishbone collagen oligopeptide powder, fishbone powder, Cortex Eucommiae extract, vitamin D is primary raw material; By following quality proportioning: marine fishbone collagen oligopeptide powder 2200g, fishbone powder 1800g, Cortex Eucommiae extract 350g, vitamin D 0.008g; Process granule in conjunction with adjuvant xylitol 900g, skim milk 300g, non-dairy creamer 220g, Fructus Vins sugar essence 220g, sucralose 7g through premix, preparation of granules, total production technology such as mix, adorn every bag of 6g, every day 1 time; Each one bag, use warm boiled water.
Embodiment 3: a kind of preparation that is used for bone density improving, prevents and treats osteoarthritis and enhancing immunity; Adopting marine fishbone collagen oligopeptide powder, fishbone powder, Cortex Eucommiae extract, vitamin D is primary raw material; By following quality proportioning: marine fishbone collagen oligopeptide powder 1700g, fishbone powder 2400g, Cortex Eucommiae extract 250g, vitamin D 0.01g; Process granule in conjunction with adjuvant xylitol 1050g, skim milk 200g, non-dairy creamer 200g, Fructus Vins sugar essence 190g, sucralose 8g through premix, preparation of granules, total production technology such as mix, adorn every bag of 6g, every day 1 time; Each one bag, use warm boiled water.
Embodiment 4: human feeding trial.Use the granule of the present invention of preparation among the embodiment 1, the effect of these article is tested.
The study subject standard: simple suffer from osteoarthritis and osteoporotic crowd, and the age is between 55～65 years old.
Experimental design and grouping: adopt two kinds of control design between self and group.By above-mentioned Standard Selection 100 routine experimenters, divide into groups according to the requirement of randomized, double-blind.Be divided into test-meal group and matched group at random by the osteoporotic situation of experimenter, consider influence result's principal element such as age, sex, diet etc. as far as possible, carry out harmony to check, with the comparability between the assurance group.Every group of experimenter's 50 examples.The test-meal group is taken this invention 1 time for each person every day, and each 1 bag, matched group is taken placebo, takes continuously 90 days.
Symptom integral is observed: by the weight scores accumulated of osteoarthritis and osteoporosis symptom (serious symptom 3 minutes, moderate 2 minutes, slight 1 minute).
The grouping situation is seen table 1.The preceding two groups of blood of test-meal, urine, just inspections such as routine and hepatic and renal function, Chest X-rays, electrocardiogram, B ultrasonic are all in normal range, and two groups of subject age, sex, the equal no significant difference of symptom integral (P＞0.05) have comparability.
Data as table 1 test-meal is last
Situation is seen table 2 after the test-meal.
Table 2 clinical symptoms integration relatively
Relatively, compare P＜0.01 between P＜0.01## group before * and the test-meal
Visible by table 2, to take back 90 days, symptom integral is improved very obviously (P＜0.01) before and after the test-meal of test-meal group, and obviously is better than matched group, and two group differences are (P＜0.01) very significantly.
The result proves that test-meal group and matched group duration of test normal diet do not change original dietary habit.After 90 days, test-meal group self and and the matched group group between relatively, clinical symptoms obviously reduces (P＜0.01).On inspection, the test-meal group has 42 people's symptoms obviously to improve, and effective percentage reaches 84%, so this invention can prevent and treat osteoarthritis, bone density improving.During the examination clothes, test-meal group prevalence is obviously low than matched group, and the body constitution enhancing, so the present invention also has the effect of enhancing immunity.And do not find toxic and side effects.
Claims (5)
1. preparation that is used for bone density improving, prevents and treats osteoarthritis and enhancing immunity; It is characterized in that it is to adopt 1500～2500 parts of marine fishbone collagen oligopeptide powder, 1500～2500 parts of fishbone powder, 200～400 parts of Cortex Eucommiae extract, 0.005～0.01 part of vitamin D, 800～1200 parts of pharmaceutic adjuvant xylitol, 200～350 parts of skim milks, 150～250 parts of non-dairy creamer, 150～250 parts in essence, 5～7 parts of preparations of processing of sucralose; Wherein Cortex Eucommiae extract is with after the Cortex Eucommiae drying and crushing; By solid-liquid ratio is the ethanol of adding 60% in 1: 10, at microwave power 400W, under 80 ℃ of conditions; Extract 10min, back concentrating under reduced pressure drying and getting.
2. the described preparation that is used for bone density improving, prevents and treats osteoarthritis and enhancing immunity of root a tree name claim 1 is characterized in that its preparation technology comprises premix, preparation of granules, total mixing.
3. the described preparation that is used for bone density improving, prevents and treats osteoarthritis and enhancing immunity of root a tree name claim 1, the dosage form that it is characterized in that it is a granule.
4. the described preparation that is used for bone density improving, prevents and treats osteoarthritis and enhancing immunity of root a tree name claim 1 is characterized in that its day clothes effective dose is 5～8g, every day 1 time, warm boiled water.
5. the described preparation that is used for bone density improving, prevents and treats osteoarthritis and enhancing immunity of root a tree name claim 1 is characterized in that it is applicable to the symptom because of having a delicate constitution of causing of bone joint pain, health shortening, hunch, the symptom that is easy to fracture and hypoimmunity that osteopathia causes, listlessness, fatigue and weak, sleep disorder.
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| CN201110098758XA CN102178934B (en) | 2011-04-20 | 2011-04-20 | Preparation for increasing bone mineral density, preventing osteoarthrosis and enhancing immunity |
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| CN201110098758XA CN102178934B (en) | 2011-04-20 | 2011-04-20 | Preparation for increasing bone mineral density, preventing osteoarthrosis and enhancing immunity |
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| CN102178934A CN102178934A (en) | 2011-09-14 |
| CN102178934B true CN102178934B (en) | 2012-12-26 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106820136A (en) * | 2017-03-06 | 2017-06-13 | 青岛海大华旗生物科技有限公司 | It is a kind of to improve the health care of sleep composition of quality and preparation method thereof |
| CN107184960A (en) * | 2017-05-19 | 2017-09-22 | 江苏江大五棵松生物科技有限公司 | It is a kind of to be used to increase Bone gillg ammonia sugar-tablet of bone density and preparation method thereof |
| CN107596356A (en) * | 2017-11-09 | 2018-01-19 | 江苏江大五棵松生物科技有限公司 | A kind of composite collagen Gly-His-Lys for increasing bone density |
| CN108095074B (en) * | 2017-12-12 | 2021-02-02 | 浙江海洋大学 | Tuna fishbone health food for adjuvant treatment of osteoporosis and preparation method thereof |
| CN108606324A (en) * | 2018-05-01 | 2018-10-02 | 张奉明 | A kind of wood frog elastin laminin peptide combinations and preparation method thereof |
| CN110651940A (en) * | 2019-10-26 | 2020-01-07 | 上海葡萄王企业有限公司 | Marine fishbone collagen oligopeptide powder solid beverage and preparation method thereof |
| CN112807416B (en) * | 2021-01-18 | 2023-05-05 | 宁波御坊堂生物科技有限公司 | Traditional Chinese medicine bone peptide composition with function of improving bone joint health and preparation method thereof |
| CN112957448A (en) * | 2021-02-08 | 2021-06-15 | 宁波御坊堂生物科技有限公司 | Composition for increasing bone mineral density, health product and preparation method thereof |
| CN112956702A (en) * | 2021-03-25 | 2021-06-15 | 江西邦泰绿色生物合成生态产业园发展有限公司 | Compound preparation for increasing bone mineral density |
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| CN101966222A (en) * | 2010-09-26 | 2011-02-09 | 林晨伟 | Medicinal composition and preparation for strengthening bones and preparation method thereof |
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