CN102132873A - Medicine or health-care food for supplementing blood and regulating immunity - Google Patents
Medicine or health-care food for supplementing blood and regulating immunity Download PDFInfo
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- CN102132873A CN102132873A CN2011100540059A CN201110054005A CN102132873A CN 102132873 A CN102132873 A CN 102132873A CN 2011100540059 A CN2011100540059 A CN 2011100540059A CN 201110054005 A CN201110054005 A CN 201110054005A CN 102132873 A CN102132873 A CN 102132873A
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Abstract
The invention discloses a medicine or health-care food for supplementing blood and regulating immunity, which comprises the following active ingredients in optimal part by weight: 0.5 part of haem iron, 6 parts of astragalus, 1 part of Chinese angelica, 1 part of donkey-hide gelatin and 3 parts of arillus longan. Clinic food try tests and pharmacological research data show that the composition indeed has remarkable blood supplementing and immunity regulating effects, has high administration safety and is suitable for long-term taking.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of medicine or health food of enriching blood and regulating immunologic function that have.
Background technology
Alimentary anemia is meant because of the necessary nutriment of body green blood, reduces relatively or utterly as materials such as iron, folic acid, dimension biogen D, makes the formation or the erythrocytic generation deficiency of hemoglobin, so that the low a kind of disease of hematopoiesis function.
Traditional Chinese medicine is categories such as this disease ownership " consumptive disease ", " deficiency of blood ".Think that blood derives from spleen, at all at kidney, and relate to the heart, liver two is dirty.If weakness of the spleen and the stomach, inability of food and drink to be digested and transported is precise and tiny, and the source of generating QI and blood deficiency will produce anaemia.Deficiency of blood the five internal organs lose supports, and just diseases such as deficiency of heart-blood, both liver and kidney deficiency can occur.
It is reported, China common people anaemia incidence reaches 15% to 20%, especially women, originally will experience physiological losing blood and hematozemia such as menstruation, pregnancy, fertility, lactation, add increasing women, not eat staple food and meat for a long time in order to keep slender stature, and suffer from alimentary anemia, this not only endangers the healthy of women, and autoimmunity is reduced, and also can further influence the health of conceived back fetus.According to statistics, there have now the infant of 30%-40% to suffer from anaemia concomitant immunity power approximately to be low, mainly is because the chain reaction that the parent anaemia causes.
Therefore,, develop a kind of safe and effective medicine or health food of enriching blood and can strengthen immunity, will have great social significance and economic worth in conjunction with traditional Chinese and western medicine theory.
Summary of the invention
Technical problem solved by the invention is: a kind of safe and effective medicine or health food of enriching blood and can strengthen immunity is provided.
Medicine or the health food that has enriching blood and strengthen immunologic function of the present invention mainly contains effective component: heme iron, the Radix Astragali, Radix Angelicae Sinensis, donkey-hide gelatin, arillus longan.Its optimum weight proportioning is: 0.5 part of heme iron, 6 parts of the Radixs Astragali, 1 part of Radix Angelicae Sinensis, 1 part in donkey-hide gelatin, 3 parts of arillus longans.
Best preparation technology of the present invention:
Get 6 kilograms of the Radixs Astragali, 1 kilogram of Radix Angelicae Sinensis, 3 kilograms of arillus longans, add 8 times of water gagings and decocted 1.5 hours, filter; Filter residue adds 6 times of water gagings and decocted 1 hour, filters, and merging filtrate concentrates, and drying is pulverized, and adds 0.5 kilogram of heme iron, 1 kilogram in donkey-hide gelatin, 12 kilograms in dextrin, Steviosin 20 grams again, makes particle.
Consumption: the particle that need the above-mentioned technology of oral one thousandth weight portion to make the every day of generally being grown up.
Beneficial effect: the present invention has enriching blood and strengthens the effect of immunity, and drug safety is good, can be used for the prevention and the treatment of alimentary anemia.
Heme iron has another name called ferriporphyrin, haematoporphyrin, X-factor, ferroheme, is a kind of long shred shape crystallization of extracting from pig, ox blood, is absorptivity height, the biological source of iron of stimulating gastrointestinal not.
The Radix Astragali has another name called yellow over sixty years of age, is the root of leguminous herbaceous plant's astragalus mongolicus, Astragalus membranacus, and the Radix Astragali has the effect that invigorating qi for consolidating superficies, arrest sweating take off, hold in the palms sore myogenic, inducing diuresis for removing edema admittedly, has the clinical medicinal history in more than 2000 year so far.Modern pharmacological research shows that the Radix Astragali contains various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper, have strengthen body's immunity, protect the liver, effect such as diuresis.
The Radix Angelicae Sinensis another name Qin is returned, cloud is returned, and is the dry root of umbelliferae angelica.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, relax bowel.Be used for sallow, the dizzy palpitaition of the deficiency of blood, irregular menstruation, asthenia cold abdominalgia, the dry constipation of intestines more.
Donkey-hide gelatin is that the skin of unhairing of equine species donkey is through boiling the glue that forms.Have and tonify the blood and arrest bleeding, nourishing yin and moistening dryness is used for cards such as sallow, the dizzy palpitaition of the deficiency of blood, flesh impotence are unable, dysphoria and insomnia, vaginal bleeding during pregnancy more.
Arillus longan is the aril of sapindaceous plant longan.Multiple efficacies such as enriching yin and nourishing kidney, tonifying middle-Jiao and Qi, tonifying heart and spleen, nourishing blood and tranquilization are arranged.
Below data illustrate beneficial effect of the present invention by experiment:
(1) the present invention treats the clinical test-meal test of alimentary anemia
1, study subject
Study subject is the low pigment anaemia of cellule, have clear and definite Fe deficiency symptoms because of and the patient of clinical manifestation.Male sex hemochrome＜130g/L, women hemochrome＜120g/L.Get rid of serious disease and mental patients such as merging is had the inclination, the cerebrovascular, liver, kidney, alimentary canal; Allergic constitution or to this given the test agent allergy sufferers; Serious anaemia patient; Take in a short time with tried function relevant article, have influence on judgement person as a result; Do not take given the test agent, data not umbra sound effect or security judgement person by standard.
2, test method
(test-meal group 56 people take this and are subjected to the reagent thing to be divided into 2 groups at random by experimenter's hemoglobin level; Control group 54 people take placebo), duration of test other hematinics of stopping using, but its life and diet are not added intervention.Test-meal process observed and recorded patient's ordinary circumstance and security physical signs.Detect free protoporphyrin in test front and back hemoglobin, serum ferritin, the red blood cell, experimental data adopts the SPSS statistical analysis, and each is organized and adopts own control design, is control design between group between 2 groups.
3, result of the test
Be subjected to the reagent thing that the influence of hemoglobin is seen Table 1.This health food of test-meal group test-meal after 30 days on average rising amplitude of hemoglobin be 24.48g/L, control group hemoglobin raise not obvious (P＞0.05).Test-meal group content of hemoglobin and control group comparison lift-off value have statistical significance (P＜0.01).
Test-meal group and control group hemoglobinometry result before and after table 1 test-meal (g/L,
)
Be subjected to the reagent thing that the influence of free protoporphyrin in the red blood cell is seen Table 2.This health food of test-meal group test-meal after 30 days in the red blood cell free protoporphyrin reduction amplitude be 47.45 μ mol/L, free protoporphyrin reduces not obvious (P＞0.05) in the control group red blood cell.Free protoporphyrin and control group relatively reduce in the test-meal group red blood cell has statistical significance (P＜0.05).
The interior free protoporphyrin measurement result of test-meal group and cellular control unit before and after table 2 test-meal (μ mol/L,
)
Be subjected to the reagent thing that the influence of serum ferritin is seen Table 3.This health food of test-meal group test-meal is the serum ferritin 40.15 μ mol/L that raise after 30 days, control group serum ferritin raise not obvious (P＞0.05).Test-meal group serum ferritin and control group relatively raise and have statistical significance (P＜0.01).
Test-meal group and control group haemocyanin measurement result before and after table 3 test-meal (μ mol/L,
)
Clinicing symptom observation: respectively at before the test-meal and after the test-meal experimenter being carried out 2 clinical symptoms inquiries.Take the examination trencherman anorexia that is subjected to the reagent thing, nervously breathe hard, cardinal symptoms such as body is tired, dizzy, abdominal distention after meal improve significantly.Take the examination trencherman clinical symptoms of placebo and do not have obvious improvement.
Take and be subjected to the reagent thing and take before and after the placebo, physical signs such as the every blood safety index of examination trencherman, stool and urine routine, Chest X-rays, electrocardiogram, ultrasound diagnosis are all in range of normal value.
Show according to this time human feeding trial result: be subjected to the reagent thing that obvious rising hemoglobin, serum ferritin are arranged, reduce the effect of free protoporphyrin in the red blood cell.And security is good, and the trencherman is healthy to have no adverse effects to trying.
(2) the present invention is to the pharmacological research of body's immunity influence
1, experimental technique
The female secondary mouse of Kunming kind (body weight 18～22 grams) is adopted in experiment, carries out following experiment respectively: (1) delayed allergy (DTH)---toes swelling thickness method; (2) T lymphopoiesis functional examination---ConA stimulates the color reaction method (mtt assay) of changeing of drenching; (3) mensuration of NK cytoactive (lactic dehydrogenase enzyme process); (4) mensuration of antibody-producting cell; (5) mensuration of serum hemolysin (HD50 pH-value determination pH method); (6) carbon is cleaned up the mensuration of index: carbon is cleaned up experiment; (7) Turnover of Mouse Peritoneal Macrophages is engulfed the chicken red blood cell experiment.
Experimental result adopts the SPSS13.0 statistical software to carry out statistical procedures.Data are all used " mean ± standard deviation
" expression, adopt variance analysis, inspection level α=0.05.
2, result
2.1 the experiment medicine aligns the influence of normal mouse body weight, thymus gland/body weight, spleen/body weight and sees Table 4.
Table 4 couple normal mouse immune organ weight's influence
By table 4 as seen, compare each dosage group body weight, thymus gland/body weight, spleen/body weight there are no significant difference (P＞0.05) with control group.
2.2 the experiment medicine aligns the influence of normal mouse delayed allergy and sees Table 5.
The influence of table 5 pair normal mouse toes swelling thickness
Compare with control group,
*P＜0.05
By table 5 as seen, compare with control group, the toes swelling thickness of middle and high dosage group significantly increases (P＜0.05).
2.3 the experiment medicine aligns the influence of normal mice spleen lymphocytes proliferation ability and sees Table 6.
The influence of table 6 pair normal mouse spleen lymphocyte ConA multiplication capacity (
λ=570nm)
By table 6 as seen, compare with control group, basic, normal, high dosage group all can significantly improve the spleen lymphocyte proliferation ability (P＜0.05) of inducing through ConA.
2.4 the experiment medicine aligns the influence of normal NK cells in mice activity and sees Table 7.
The influence of table 7 pair normal NK cells in mice activity
Compare with control group,
*P＜0.05
By table 7 as seen, compare with control group, the NK cytoactive of middle dosage group significantly improves (P＜0.05).
2.5 the experiment medicine aligns the influence of normal mouse antibodies cellulation (PFC) and sees Table 8.
The influence of table 8 couple normal mouse PFC
Compare with control group,
*P＜0.05
By table 8 as seen, compare with control group, the PFC of middle dosage group significantly improves (P＜0.05).
2.6 the experiment medicine aligns the influence of normal mice serum hemolysin level and sees Table 9.
Table 9 couple normal mice serum HC
50The influence of level
Compare with control group,
*P＜0.05
By table 9 as seen, compare the HC of middle and high dosage group with control group
50Significantly improve (P＜0.05).
2.7 the experiment medicine aligns the influence that normal mouse carbon cleans up ability and sees Table 10.
The table 10 pair influence that normal mouse carbon is cleaned up
Compare with control group,
*P＜0.05
By table 10 as seen, compare with control group, the carbon of middle and high dosage group is cleaned up index and is significantly improved.
2.8 engulfing chicken red blood cell test (half intracorporal method) to Turnover of Mouse Peritoneal Macrophages, the experiment medicine sees Table 11.
The influence of table 11 pair Turnover of Mouse Peritoneal Macrophages phagocytic activity
Compare P＜0.05 with control group
By table 11 as seen, be subjected to the reagent object height, in, low dose group phagocytic rate, phagocytic index and normal control group relatively have conspicuousness to increase (P＜0.05).
Analyze experimental result, be subjected to the reagent thing can increase the toes swelling thickness of normal mouse, raising NK cytoactive, serum hemolysin level, antibody-producting cell quantity, carbon are cleaned up phagocytic index and macrophage phagocytic chicken red blood cell ability, and prompting is subjected to the reagent thing to have the function that strengthens immunity of organism.
The specific embodiment
Embodiment 1:
Take by weighing 6 parts of the Radixs Astragali, 1 part of Radix Angelicae Sinensis, 3 parts of arillus longans, add 8 times of water gagings and decocted 1.5 hours, filter; Filter residue adds 6 times of water gagings and decocted 1 hour, filters, and merging filtrate concentrates, and drying is pulverized, and adds 0.5 part of heme iron, 1 part in donkey-hide gelatin, 12 parts in dextrin, 0.02 part of Steviosin again, makes granule.
Embodiment 2:
Take by weighing 1 part of the Radix Astragali, 0.1 part of Radix Angelicae Sinensis, 0.5 part of arillus longan, add 5 times of water gagings and decocted 0.5 hour, filter; Filter residue adds 5 times of water gagings decoctions 0.5 hour, filters, and merging filtrate concentrates, and drying is pulverized, and adds 0.01 part of heme iron, 0.1 part in donkey-hide gelatin, incapsulates shell, gets capsule.
Embodiment 3:
Take by weighing the medicinal material of following weight proportion: 30 parts of the Radixs Astragali, 50 parts of Radix Angelicae Sinensis, 60 parts of arillus longans, add 12 times of water gagings and decocted 2 hours, filter; Filter residue adds 12 times of water gagings and decocted 2 hours, filtration, and merging filtrate concentrates, and drying is pulverized, and adds 50 parts of heme irons, 10 parts in donkey-hide gelatin, 10 parts of starch, granulates, and compressing tablet gets tablet.
Embodiment 4:
Take by weighing 6 parts of the Radixs Astragali, 1 part of Radix Angelicae Sinensis, 3 parts of arillus longans, add 8 times of water gagings and decocted 1.5 hours, filter; Filter residue adds 6 times of water gagings and decocted 1 hour, filters, and merging filtrate concentrates, and drying is pulverized, and gets extract.Add 0.5 part of heme iron, 1 part in donkey-hide gelatin, 12 parts of polyethylene glycol (PEG6000) again, system is dripped in fusion, gets pill.
Claims (5)
1. one kind has the medicine or the health food of enriching blood and regulating immunologic function, it is characterized in that containing effective ingredient: heme iron, the Radix Astragali, Radix Angelicae Sinensis, donkey-hide gelatin, arillus longan.
2. according to claim 1 have the medicine or a health food of enriching blood and regulating immunologic function, it is characterized in that its weight proportion that contains each active ingredient is: heme iron 0.01-50 part, Radix Astragali 1-30 part, Radix Angelicae Sinensis 0.1-50 part, donkey-hide gelatin 0.1-10 part, arillus longan 0.5-60 part.
3. according to claim 2 have the medicine or a health food of enriching blood and regulating immunologic function, it is characterized in that its weight proportion that contains each active ingredient is: 0.5 part of heme iron, 6 parts of the Radixs Astragali, 1 part of Radix Angelicae Sinensis, 1 part in donkey-hide gelatin, 3 parts of arillus longans.
4. describedly have the medicine or a health food of enriching blood and regulating immunologic function according to claim 2 or 3, it is characterized in that its preparation technology is: the Radix Astragali, Radix Angelicae Sinensis, the arillus longan that take by weighing above-mentioned weight proportion, add 5-12 times of water gaging and decocted 0.5-2.5 hour, filter; Filter residue adds 5-12 times of water gaging again and decocted 0.5-2.5 hour, filters, and merging filtrate concentrates, and drying is pulverized, and gets extract, adds heme iron, donkey-hide gelatin again, makes the conventional peroral dosage form of pharmacy.
5. describedly have the medicine or a health food of enriching blood and regulating immunologic function according to claim 2 or 3, it is characterized in that its preparation technology is: take by weighing the Radix Astragali, Radix Angelicae Sinensis, the arillus longan of above-mentioned weight proportion, add 8 times of water gagings and decocted 1.5 hours, filter; Filter residue adds 6 times of water gagings and decocted 1 hour, filters, and merging filtrate concentrates, and drying is pulverized, and gets extract, adds heme iron, donkey-hide gelatin, 12 parts in dextrin, 0.02 part of Steviosin again, makes granule.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621537A (en) * | 2015-01-09 | 2015-05-20 | 无锡商业职业技术学院 | Seasoning sauce with leek fragrance and processing method of seasoning sauce with leek fragrance |
| CN105770133A (en) * | 2014-12-19 | 2016-07-20 | 烟台宝备生物技术有限公司 | Medicine or health food with blood enriching and immunity adjusting functions |
| CN107772345A (en) * | 2017-12-12 | 2018-03-09 | 桐城市天地泰农业科技有限公司 | A kind of multi-flavor mends iron apple dry powder and preparation method thereof |
| CN109432409A (en) * | 2018-12-19 | 2019-03-08 | 上海康孕企业管理合伙企业（有限合伙） | Application of the ferroheme in the drug, Food and hygienical food of improvement dysmenorrhea |
-
2011
- 2011-02-27 CN CN2011100540059A patent/CN102132873A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770133A (en) * | 2014-12-19 | 2016-07-20 | 烟台宝备生物技术有限公司 | Medicine or health food with blood enriching and immunity adjusting functions |
| CN104621537A (en) * | 2015-01-09 | 2015-05-20 | 无锡商业职业技术学院 | Seasoning sauce with leek fragrance and processing method of seasoning sauce with leek fragrance |
| CN107772345A (en) * | 2017-12-12 | 2018-03-09 | 桐城市天地泰农业科技有限公司 | A kind of multi-flavor mends iron apple dry powder and preparation method thereof |
| CN109432409A (en) * | 2018-12-19 | 2019-03-08 | 上海康孕企业管理合伙企业（有限合伙） | Application of the ferroheme in the drug, Food and hygienical food of improvement dysmenorrhea |
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Application publication date: 20110727 |