CN105533712A - Composition used for increasing bone density and enhancing immunity - Google Patents

Composition used for increasing bone density and enhancing immunity Download PDF

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Publication number
CN105533712A
CN105533712A CN201511025471.9A CN201511025471A CN105533712A CN 105533712 A CN105533712 A CN 105533712A CN 201511025471 A CN201511025471 A CN 201511025471A CN 105533712 A CN105533712 A CN 105533712A
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China
Prior art keywords
powder
composition
bone density
vitamin
increasing bone
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CN201511025471.9A
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Chinese (zh)
Inventor
李金元
刘新春
未伟
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Tianjin Tiens Biological Development Co Ltd
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Tianjin Tiens Biological Development Co Ltd
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Priority to CN201511025471.9A priority Critical patent/CN105533712A/en
Publication of CN105533712A publication Critical patent/CN105533712A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention provides a composition used for increasing bone density and enhancing immunity. The composition is prepared by mixing collagen peptide, bone meal subjected to enzymatic hydrolysis, colostrum basic protein and vitamins, and the collagen peptide, bone meal subjected to enzymatic hydrolysis, colostrum basic protein, vitamins and mineral substances in the composition are combined with one another and have synergistic interaction to increase the bone density remarkably; meanwhile, while flowing through each part of a body along with blood, immune cells penetrate through a blood vessel wall to get close to external foreign matters so as to be timely combined with the collagen peptide, so that an immune function to the foreign matters, macrophage, lymphocyte, plasma cells, immune globulin and the like is generally improved, and therefore, the immunity of a human body is improved.

Description

For increasing bone density and the composition of develop immunitypty
Technical field
The present invention relates to a kind of health-related composition, especially a kind of for increasing bone density and the composition of develop immunitypty.
Background technology
Bone is the complicated organism be made up of bone matrix and bone mineral.The main component of bone matrix is collagen, and the main component of bone mineral is calcium hydroxy phosphate.First the generation of bone is synthesis collagen, collagenous fibres are intertwined to form matrix net, then calcium, phosphorus are deposited in collagen stroma net with the form of calcium hydroxy phosphate, therefore do not have ossein just can not Cheng Qiwei bone in bone, and be the accumulation of many hydroxyapatite molecules and particle, not having enough osseins carrying out eubolism in bone, will be not strong and unsound.
Collagen is rich in the amino acid such as glycine, proline, hydroxyproline that human body needs.Collagen is most important part in extracellular matrix.Calcium in blood plasma is still transported to the delivery vehicle of osteocyte by hydroxyproline contained in collagen.If lack collagen, prevent and treat osteoporosis with replenishing the calcium merely, more calcium also cannot improve.
The height of body immunity is called that with some the raw body molecule of immunoglobulin (Ig) is relevant, as lymph corpuscle and macrophage, when alien material is invaded, immunocyte is general just like army, can put up a resistance to alien material, surrounded by foreign matter and engulf, even self-sacrifice is healthy to keep.So immunocyte is strongr, and external enemy just can kill and subtracts by number enough words completely, otherwise health will be made sick.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for increasing bone density and the composition of develop immunitypty.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of for increasing bone density and the composition of develop immunitypty, it is characterized in that, said composition is made up of collagen peptide, enzymolysis bone meal, first milk basic protein, vitamin and mineral matter, by its weight parts collagen peptide 10-60 part, enzymolysis bone meal 10-50 part, first milk basic protein 0.1-3 part, vitamin 0.01-1 part, mineral matter 0.01-1 part; Wherein, described mineral matter is one or more in calcium, sodium, zinc, phosphorus, potassium, magnesium, manganese, copper, boron, chromium, iron, iodine, selenium, and described vitamin is any combination of one or more in VA, VC, VD, VE, VK, VB race.
Preferably, above-mentioned for increasing bone density and the composition of develop immunitypty, by its weight parts collagen peptide 20-50 part, enzymolysis bone meal 20-40 part, first milk basic protein 0.5-2.5 part, vitamin 0.05-0.8 part, mineral matter 0.05-0.8 part.
Preferably, above-mentioned for increasing bone density and the composition of develop immunitypty, by its weight parts collagen peptide 30-40 part, enzymolysis bone meal 25-35 part, first milk basic protein 1-2 part, vitamin 0.1-0.5 part, mineral matter 0.1-0.5 part.
Preferably, for increasing bone density and the composition of develop immunitypty, it is characterized in that, by its weight parts collagen peptide 15 parts, enzymolysis bone meal 15 parts, first milk basic protein 1 part, vitamin 0.1 part, 0.1 part, mineral matter.
Preferably, described mineral matter is made up of calcium, zinc, magnesium, copper, chromium and iron, by its weight parts calcium 80 parts, 1 part, zinc, 15 parts, magnesium, copper 0.1 part, chromium 0.01 part.
Preferably, described vitamin is made up of VA, VC, VD, VE, VK, by its weight parts VA10 part, VC1000 part, VD0.1 part, VE1000 part, VK1 part.
For increasing bone density and the composition of develop immunitypty, also comprise cereal and reconstitute powder, crystal diabetin, Fruit powder, maltodextrin and silica composition, reconstitute powder 1-95 part, crystal diabetin 1-50 part, Fruit powder 1-40 part, maltodextrin 1-20 part, silica 0.1-2 part by its weight parts cereal.
Preferably, described Fruit powder is any combination of one or more in apple powder, kiwi fruit powder, mangosteen powder, coconut powder, mango powder, passionflower powder, pineapple powder, honey peach powder, manaca powder, acerola concentrate powder, A Sayi fruit powder, grape fruit powder, guava powder, lemon powder, strawberry powder, dragon fruit powder.
Above-mentioned for increasing bone density and the preparation method of the composition of develop immunitypty, concrete preparation process is as follows:
(1) each component in prescription is taken by prescription amount for subsequent use;
(2) each component is mixed, to obtain final product.
The invention has the beneficial effects as follows:
Above-mentioned for increasing bone density and the composition of develop immunitypty, collagen peptide, enzymolysis bone meal, first milk basic protein, vitamin and mineral matter be combined with each other, each component Synergistic, increase bone density Be very effective, simultaneously when immunocyte with blood flow through health everywhere time, can through vascular wall, be combined in time with collagen peptide close to immunocyte during external foreign matter, antagonism foreign matter, macrophage, lymph corpuscle, the immunity function such as plasma cell and immunoglobulin (Ig) bulking property promotes, increase resistance of human body, adopt solid beverage formulation, mouthfeel is good, easy absorption, be convenient to take, its preparation method is simple, is applicable to the needs that large-scale industrial is produced.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
For increasing bone density and a composition for develop immunitypty, be made up of collagen peptide, enzymolysis bone meal, first milk basic protein, vitamin and mineral matter, concrete consumption is in table 1, and described composition is obtained by following method:
(1) each component in prescription is taken by prescription amount for subsequent use;
(2) each component is mixed, to obtain final product.
Table 1
Described mineral matter is made up of calcium, zinc, magnesium, copper, chromium and iron, by its weight parts calcium 80 parts, 1 part, zinc, 15 parts, magnesium, copper 0.1 part, chromium 0.01 part; Described vitamin is made up of VA, VC, VD, VE, VK, by its weight parts VA10 part, VC1000 part, VD0.1 part, VE1000 part, VK1 part.
Embodiment 2
A kind of for increasing bone density and the composition of develop immunitypty, reconstituted powder, crystal diabetin, Fruit powder, maltodextrin, first milk basic protein, vitamin, mineral matter and silica formed by collagen peptide, enzymolysis bone meal, cereal, concrete consumption is in table 2, and described composition is obtained by following method:
(1) each component in prescription is taken by prescription amount for subsequent use;
(2) each component is mixed, to obtain final product.
Table 2
Described mineral matter is made up of calcium, zinc, magnesium, copper, chromium and iron, by its weight parts calcium 80 parts, 1 part, zinc, 15 parts, magnesium, copper 0.1 part, chromium 0.01 part; Described vitamin is made up of VA, VC, VD, VE, VK, by its weight parts VA10 part, VC1000 part, VD0.1 part, VE1000 part, VK1 part; Described Fruit powder is combined by the weight ratio such as apple powder, kiwi fruit powder, mangosteen powder, coconut powder, mango powder, passionflower powder, pineapple powder, honey peach powder, manaca powder, acerola concentrate powder, A Sayi fruit powder, grape fruit powder, guava powder, lemon powder, strawberry powder and dragon fruit powder and obtains.
Efficacy experiments:
Sample: composition described in embodiment 1-1.
One, bone density experiment is increased
(1) oophorectomize: rat, with dosage lumbar injection 1% Nembutal sodium solution of 30mg/kgbw, carries out Bilateral oophorectomy after anesthesia, the penicillin of postoperative muscle injection 20,000 units, for three days on end.Sham-operation group only excises 0.5g fat after opening abdominal cavity, retains bilateral ovaries.Latter 5 days of rat ovary excision, carries out vaginal smear examination, rejects the incomplete rat of oophorectomize.
(2) animal grouping: above-mentioned female castrated rats is divided into basic, normal, high three the dosage groups of model control group, high dose calcium carbonate control group and sample at random by body weight.Set up sham-operation group simultaneously.Often organize 10, single cage is raised, and feeds 3 months.
(3) thighbone density measures: at the end of experiment, and rat is put to death in the dislocation of strength vertebra, peels off right femur, through 105 DEG C of bakings 8 hours, after being cooled to room temperature, measures the bone density (BMD) of femur midpoint and distal end.
(4) calcium content of bone measures: after weighing the gross weight of femur, put into the triangular flask through HCl treatment dry cleansing, add nitric acid+perchloric acid (4:1) mixed acid 15ml, deionized water constant volume is used after digestion, measure calcium content of bone with atomic absorption spectrophotometer, each mensuration makes Quality Control material by the GBW07604 Poplar leaves of State Bureau of Technical Supervision's approval.
(5) test data statistics: carry out variance analysis with SPSS software.
(6) result judges: not based on the product of replenishing the calcium (can contain a small amount of calcium), model control group calcium content of bone or bone density, significantly lower than sham-operation group, show to cause the low drag of rat bone density; The calcium content of bone of oophorectomize+animal subject group or bone density comparatively model control group significantly increase, and be not less than the calcium carbonate control group of corresponding dosage, and other indexs (except body weight) are not significantly lower than model control group, can judge that this tested material has the effect increasing bone density.Experimental result is in table 3.
Table 3
Experimental result shows: calcium content of bone, femur center density, femur distal end density are significantly higher than model control group P < 0.05, and this given the test agent (embodiment 1-1 composition) has the effect increasing bone density.
Two, develop immunitypty experiment
(1) calculate a dosage group and a negative control group according to day for human beings taking dose, give and corresponding dosage, negative control group gives pure water, every day gavage once, continuous gavage 30-35d.
(2) internal organs/weight ratio pH-value determination pH: test is end eventually, the mouse of weighing after putting to death, takes out Thymus and spleen, at scales/electronic balance weighing, calculates dirty/body ratio
(3) the mouse spleen lymphocyte transformation experiment of ConA induction, test is end eventually, carries out lymphocytic multiplication capacity detection by mtt assay.
(4) the mouse DTH experiment of dinitrofluorobenzene induction
(5) mensuration of serum hemolysin and antibody-producting cell detect
(6) mouse carbonic clearance experiment
(7) Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell experiment
(8) result judges: the requirement evaluated according to health food, positive in any two in cellular immune function, humoral immune function, monocytes/macrophages function, NK cytoactive four, can judge that this given the test agent (embodiment 1-1 composition) has develop immunitypty function.Experimental result is in table 4.
Table 4
Test shows, sample compares with negative control group mouse cell immunologic function, humoral immune function, monocytes/macrophages function, difference has statistical significance (P < 0.05), to NK cytoactive no significant difference compared with negative control group.The requirement of health food evaluation judges that this sample has the effect increasing immunity.
Above-mentioned with reference to embodiment to this for increasing bone density and the composition of the develop immunitypty detailed description of carrying out; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.

Claims (8)

1. one kind for increasing bone density and the composition of develop immunitypty, it is characterized in that, said composition is made up of collagen peptide, enzymolysis bone meal, first milk basic protein, vitamin and mineral matter, by its weight parts collagen peptide 10-60 part, enzymolysis bone meal 10-50 part, first milk basic protein 0.1-3 part, vitamin 0.01-1 part, mineral matter 0.01-1 part;
Described mineral matter is one or more in calcium, sodium, zinc, phosphorus, potassium, magnesium, manganese, copper, boron, chromium, iron, iodine, selenium;
Described vitamin is one or more in VA, VC, VD, VE, VK, VB race.
2. according to claim 1 for increasing bone density and the composition of develop immunitypty, it is characterized in that, by its weight parts collagen peptide 20-50 part, enzymolysis bone meal 20-40 part, first milk basic protein 0.5-2.5 part, vitamin 0.05-0.8 part, mineral matter 0.05-0.8 part.
3. according to claim 1 for increasing bone density and the composition of develop immunitypty, it is characterized in that, by its weight parts collagen peptide 30-40 part, enzymolysis bone meal 25-35 part, first milk basic protein 1-2 part, vitamin 0.1-0.5 part, mineral matter 0.1-0.5 part.
4. according to claim 1 for increasing bone density and the composition of develop immunitypty, it is characterized in that, by its weight parts collagen peptide 15 parts, enzymolysis bone meal 15 parts, first milk basic protein 1 part, vitamin 0.1 part, 0.1 part, mineral matter.
5. according to claim 1 for increasing bone density and the composition of develop immunitypty, it is characterized in that, described mineral matter is made up of calcium, zinc, magnesium, copper, chromium and iron, by its weight parts calcium 80 parts, 1 part, zinc, 15 parts, magnesium, copper 0.1 part, chromium 0.01 part.
6. according to claim 1 for increasing bone density and the composition of develop immunitypty, it is characterized in that, described vitamin is made up of VA, VC, VD, VE, VK, by its weight parts VA10 part, VC1000 part, VD0.1 part, VE1000 part, VK1 part.
7. according to the arbitrary claim of claim 1-6 for increasing bone density and the composition of develop immunitypty, it is characterized in that, also comprise the auxiliary material of following weight portion: cereal reconstitutes powder 1-95 part, crystal diabetin 1-50 part, Fruit powder 1-40 part, maltodextrin 1-20 part, silica 0.1-2 part.
8. according to claim 7 for increasing bone density and the composition of develop immunitypty, it is characterized in that, described Fruit powder is one or more in apple powder, kiwi fruit powder, mangosteen powder, coconut powder, mango powder, passionflower powder, pineapple powder, honey peach powder, manaca powder, acerola concentrate powder, A Sayi fruit powder, grape fruit powder, guava powder, lemon powder, strawberry powder, dragon fruit powder.
CN201511025471.9A 2015-12-29 2015-12-29 Composition used for increasing bone density and enhancing immunity Pending CN105533712A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105996049A (en) * 2016-06-15 2016-10-12 天津天狮生物发展有限公司 Child instant medicine for boosting immunity
CN105996059A (en) * 2016-06-15 2016-10-12 天津天狮生物发展有限公司 Composition for increasing bone mineral density
CN107927511A (en) * 2017-12-14 2018-04-20 苏州维高能生物技术有限公司 A kind of nutrition-balanced solid beverage
CN108576816A (en) * 2018-03-09 2018-09-28 黑龙江飞鹤乳业有限公司 A kind of composition increasing bone density
CN108968075A (en) * 2018-07-05 2018-12-11 天津市益倍建生物技术有限公司 It is a kind of improve bone health composition and its application
CN112956702A (en) * 2021-03-25 2021-06-15 江西邦泰绿色生物合成生态产业园发展有限公司 Compound preparation for increasing bone mineral density

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105996049A (en) * 2016-06-15 2016-10-12 天津天狮生物发展有限公司 Child instant medicine for boosting immunity
CN105996059A (en) * 2016-06-15 2016-10-12 天津天狮生物发展有限公司 Composition for increasing bone mineral density
CN107927511A (en) * 2017-12-14 2018-04-20 苏州维高能生物技术有限公司 A kind of nutrition-balanced solid beverage
CN108576816A (en) * 2018-03-09 2018-09-28 黑龙江飞鹤乳业有限公司 A kind of composition increasing bone density
CN108968075A (en) * 2018-07-05 2018-12-11 天津市益倍建生物技术有限公司 It is a kind of improve bone health composition and its application
CN112956702A (en) * 2021-03-25 2021-06-15 江西邦泰绿色生物合成生态产业园发展有限公司 Compound preparation for increasing bone mineral density

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Application publication date: 20160504