CN102160614B - Compound preparation for improving immunity of human bodies and enhancing bone density and application thereof - Google Patents
Compound preparation for improving immunity of human bodies and enhancing bone density and application thereof Download PDFInfo
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- CN102160614B CN102160614B CN2010105866587A CN201010586658A CN102160614B CN 102160614 B CN102160614 B CN 102160614B CN 2010105866587 A CN2010105866587 A CN 2010105866587A CN 201010586658 A CN201010586658 A CN 201010586658A CN 102160614 B CN102160614 B CN 102160614B
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Abstract
The invention relates to a compound preparation for improving the immunity of human bodies and enhancing bone density and application thereof. The compound preparation comprises the following active ingredients in part by weight: 2 to 15 parts of yak marrow powder, 0.5 to 5 parts of ossein protein, 5 to 35 parts of coix seed, 5 to 35 parts of cinnamomvine, 2 to 15 parts of lotus seed, 2 to 8 parts of apricot kernel, 5 to 35 parts of fructo-oligosaccharide, 0.01 to 1 part of casein phosphopeptides and 0.01 to 5 parts of enzymes. Compared with other conventional products in the prior art, the compound preparation has a high-quality calcium source; required nutrient substances are replenished comprehensively according to the metabolic law of physiological tissues of skeletons; and the casein phosphopeptides, bifidus factors and the enzymes are added by combining the digestive absorption condition of gastrointestinal tracts of the human bodies to promote digestive absorption of the human bodies on calcium and other nutrient substances, so the bioavailability is improved greatly and the curative effect of the product is ensured.
Description
Technical field
The present invention relates to a kind of compound formulation and uses thereof with raising body immunity and enhance bone density.
Background technology
Calcium is the maximum metallic element of people's in-vivo content, grows indispensable material for people's bulk-growth, also is one of element that lacks the most easily.The calcium of human body is distributed in bone and the tooth mostly, accounts for 99% of total amount, and all the other 1% are distributed in blood, intercellular fluid and the soft tissue.The osteoporosis that the long-term lacking of calcium can cause.Numerous researchs show, loss has the important effect that slows down to sclerotin to increase the intake of calcium, important function are also arranged aspect the fracture rates that is caused by osteoporosis reducing." Chinese residents nutrition and Health Situation " investigation shows that my urban and urual areas of whole country's calcium intake is merely 391 milligrams per capita, is equivalent to 41% of recommended intake.Simultaneously; Along with the prolongation of human longevity, aging population brings new problem to human health, and osteoporosis (OP) and the fracture that causes thereof are positioned at the prostatitis in current common disease; The elderly's health in serious threat, has become social public health health problem of China.China is calcium intake country on the low side in resident's diet nutritional, and the osteoporotic anti-rules of treatment to be to put prevention first, so this series products has great demand, this has the product of much replenishing the calcium also can find out from market.
Though the main mine material of bone is a calcium, osteoporosis is not only because of calcium deficiency, but a kind of metabolic disease, with old and feeble relevant.Osteoporosis is the bone of porous, and is more crisp than normal bone, the easy fracture.And motherland's medical science thinks that the sick position of osteoporosis is at bone; The cause of disease is mainly returned and is suffered from a deficiency of the kidney, and the successive dynasties medical book records the theory of " kidney master bone ", " bone fistula person is arranged, and the kidney tonifying method is to control it "; Think that osteoporotic fracture mainly causes marrow exhaustion by the qi deficiency to blood stasis of holding concurrently of lumbago due to " suffering from a deficiency of the kidney "; Due under slight external force effect, therefore, traditional Chinese medical science Prevention and Treatment of Osteoporosis is many starts with from kidney tonifying.The present invention then carries out composition of prescription from using modern medicine and traditional Chinese medical theory, brings into play the chief separately, plays the effect of complex treatment.
The currently marketed product of replenishing the calcium, majority is simple supplement calcium, and human bioavailability is not high, and onset is slow, and effect is not obvious, can not really satisfy the bone growth metabolic demand.
Summary of the invention
Main purpose of the present invention is to overcome the deficiency of calcium-supplementing preparation in the prior art; Utilize modern medicine and traditional Chinese medical theory; A kind of compound preparation that improves body immunity and enhance bone density that has is provided; Can replenish the required nutrition of bone balanced, all sidedly, regulate body immunity, strong bone.
Another object of the present invention is to provide the purposes of this compound formulation.
The present invention adopts following technical scheme:
A kind of compound preparation with raising body immunity and enhance bone density, the weight proportion of its active ingredient is following: yak marrow powder 2-15 part, bone collagen 0.5-5 part; Coix seed 5-35 part, Chinese yam 5-35 part, lotus seeds 2-15 part; Almond 2-8 part; FOS 5-35 part, CPP 0.01-1 part, ferment 0.01-5 part.
Preferably, the following yak marrow powder 5-10 of the weight proportion of the active ingredient of above-mentioned compound preparation part, bone collagen 2-5 part, coix seed 20-30 part; Chinese yam 16-28 part, lotus seeds 6-12 part, almond 3-8 part; FOS 16-32 part, CPP 0.05-0.5 part, ferment 0.1-3 part.
Described compound preparation is a pulvis, and its preparation method is following: with coix seed, Chinese yam, lotus seeds, almond crushing screening; Adopt the equivalent method of progressively increasing to mix with yak marrow powder, bone collagen, FOS, CPP, ferment, can gets final product again.
Said ferment (being organized enzyme) is selected from a kind of or its combination in starch amylase, proteolytic enzyme, lipase and the fiber amylase.
The application of above-mentioned compound preparation in the product of preparation raising body immunity and enhance bone density.
Prescription mechanism of the present invention is following:
This prescription is according to the elderly's physiological and pathological feature; Replenish the calcium and the nutrition bone with yak marrow powder and bone collagen; Add Chinese medicine in conjunction with traditional Chinese medical theory, carry out comprehensively regulating through the classical theory of traditional Chinese medical science of strengthening spleen, tonifying kidney with medicine-food two-purpose of transferring tonifying five zang organs.Traditional Chinese medicine is thought, comes to one's autumn, and insufficiency of the spleen then kidney loses to grow the day after tomorrow and helps, and causes the skeleton inanition eventually, bone wither need not and the generation osteoporosis, osteoporosis is to cause a little less than spleen is suffered from a deficiency of the kidney.Add in the prescription and can improve person in middle and old age's spleen suffer from a deficiency of the kidney weak Chinese yam, coix seed, lotus seeds, nurse one's health human body, the tonifying spleen kidney comprehensively.Chinese yam tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying.Coix seed invigorating the spleen excreting dampness.The lotus seeds beneficial gas of can making light of one's life by commiting suicide improves the health, and also has the heat-clearing stasis of blood of loosing, mental-tranquilization, kidney tonifying, beneficial bone, effects such as cool blood.But the almond smoothing lung, relieving cough, eliminating phlegm, long-pending laxation defaecation disappears.These article have not only replenished enrich calcareous, the conditioning function of intestinal canal; More contain base nutrients matter and immune substances such as inorganic mineral nutrition such as zinc, iron, phosphorus and bone collagen, BMP, chondroitin, amino acid, vitamin; Can replenish the required various nutrition of bone balanced, all sidedly; Regulate body immunity, thereby help the prevention and the rehabilitation of sufferers of osteoporosis face.Added the absorption that CPP promotes calcium in the prescription, simultaneously compatibility Oilgosaccharkdes (FOS) and ferment, not only help catapepsis of various nutrients mass-energy and absorption in the prescription; Improve bioavilability; Can also adjust the gut flora ecological balance, guarantee that stomach recovers normal function, makes defecation smooth and easy; Enhance metabolism the conditioning body.The present invention is scientific and reasonable, and exact efficacy has very high Dietotherapy health and is worth.
In sum, compared with prior art, a kind of compound preparation with raising body immunity and enhance bone density of the present invention has following beneficial effect:
At first, the present invention compares with existing other products, has the more calcium source of high-quality, and the yak marrow powder that adopts pure natural is as the calcium source, and calcium-phosphorus ratio is 2: 1, is easy to digest and assimilate, and is particularly suitable for the elderly and takes for a long time, safe without toxic side effect; Science compatibility bone collagen not only can suppress calcium and from bone, run off, and improves the absorption of calcium; And can increase skeleton density, and slow down the aging of marrow, increase toughness, intensity and the elasticity of bone, suppress the bone amount and reduce, improve the metabolism of bone, regulate osteocyte, increase bone toughness.
Secondly; The present invention combines classical tcm theory when using the theory of modern medicine and nutrition; Chinese and Western combines, and the unique advantage of performance traditional Chinese medicine aspect prevention and treatment person in middle and old age's chronic disease and rehabilitation health is according to the physiological characteristics of human pathology; Comprehensive supplement calcium, the nutrition bone.
The 3rd, the present invention comprehensively replenishes the desired nutritional material according to physiological tissue's metabolic rule of bone; Digest and assimilate situation in conjunction with human gastrointestinal tract, add the absorption that CPP promotes calcium, Oilgosaccharkdes helps to adjust the gut flora ecological balance, guarantees that stomach recovers normal function.
The 4th, the special ferment (being organized enzyme) that adds among the present invention, thus brought into play its effect through various nutrients mass-energy in the feasible prescription of the catalytic action of ferment by fully digestion, absorption, greatly improved bioavilability, guarantee the curative effect of product.
The present invention shows that through the clinical testing Primary Study sufferers of osteoporosis face can significantly be alleviated clinical symptoms such as ostalgia, cramp behind these article of taking.The invention product carries out effect through HSPH of Southeast China University, Nanjing public health preventive medicine research institute and detects, and these article calcium absorbs good, has the effect that increases the bone density function.
The specific embodiment
Embodiment one
9 parts of yak marrow powders, 4 parts of bone collagens, 24 parts of coix seeds, 23 parts of Chinese yams, 10 parts in lotus seeds, 5 parts in almond, 25 parts of FOSs, 0.08 part of CPP, 0.5 part in ferment.With coix seed, Chinese yam, lotus seeds, almond crushing screening; Adopt the equivalent method of progressively increasing to mix with yak marrow powder, bone collagen, FOS, CPP, ferment again, adopt the can of full-automatic sterile bottle placer to get final product.
Through Fujian Center for Disease Control & Prevention product is carried out physics and chemistry detection, hygiene detection, three months accelerated tests.Result of the test shows that this quality meets national correlation technique standard, the product quality stable homogeneous, and index safety is controlled.
Product of the present invention carries out toxicology, Ergonomy detection through HSPH of Southeast China University, Nanjing public health preventive medicine research institute, and detection case is following.
1, by " health food security toxicological evaluation standard and the detection method standard " of Ministry of Public Health issue these article are invented product and carry out health food security toxicological evaluation, testing result and judgement as follows:
1., acute toxicity test: irritate stomach and tried after the thing; Do not see tangible poisoning symptom, animal does not have death in the 14d, is tried the acute toxicology property MTD＞10.0g/KgBw of thing to female, male two kinds of sex mouse; According to acute toxicology property toxicity grading standard, the nontoxic level in the true border of this product.
2., genetic toxicity test: these article of Salmonella reversion test demonstration are not seen mutagenesis; These article of bone marrow cell micronucleus result of the test demonstration are not seen mutagenesis; The mouse sperm deformity result of the test shows that these article are to the mouse sperm hereditary-less toxicity.
3., 30 days feeding trials of rat: compare with control group; The ordinary circumstance of three dose groups rats of product of the present invention, body weight, bioavailability, hematology, blood biochemical are learned, the equal no abnormality seen of liver body wall and histopathologic examination, point out these article to internal organs not damaged effects such as liver,kidney,spleen, stomach, duodenum, ovary, testis.
2, according to " health food function assessment assessment process and method of inspection standard " in " the health food security toxicological evaluation standard and the detection method standard " of Ministry of Public Health's issue, these article are increased the bone density function test.
1., bone density function test: administration was tried thing after 3 months; The body weight of basic, normal, high three dose groups of these article and calcium carbonate control group rat all is higher than low calcium control group (P＜0.05%), and the difference between high dose group rat and the calcium carbonate control group does not have conspicuousness (P＞0.05%).Give these article (be equivalent to respectively human body recommended amounts 5 times, 10 times, 20 times) of the basic, normal, high dosage of rat; The result finds that the calcium content of bone of middle and high two dose groups and calcium carbonate control group rat after 3 months is apparently higher than low calcium control group (P＜0.05%); The bone density of basic, normal, high three dose groups of while and calcium carbonate group control rats is apparently higher than low calcium control group (P＜0.05%), and high dose group calcium content of bone and bone density and calcium carbonate control group difference do not have conspicuousness (P＞0.05%).According to increasing the principle that bone density functional check methods and results is judged in " health food function assessment assessment process and method of inspection standard ", these article have the effect that increases the bone density function.
2., calcium absorption test
Test method: select 50 of female cleaning level SD ablactation rats for use, body weight 60～75g, Si Laike experimental animal Co., Ltd provides by Shanghai; Animal production licence number SCXK (Shanghai) 2003-003, animal adaptability was fed after 10 days, fasting 12 hours; Be divided into 5 groups at random by body weight, 10 every group.Dosage is grouped into low calcium control group, high dose calcium carbonate dose groups, given the test agent and sets up high, normal, basic three dose groups separately.After animal adapted to 10 days, single cage raised for 4 weeks.Drink deionized water to avoid from drinking-water, obtaining calcium, duration of test routine observation rat ordinary circumstance is measured height, body weight weekly once.Carry out calcium metabolism test in 3 days after testing for 3 weeks.Write down 3 days food-intakes, collect 72 hours ight soil, measure calcium content in feed and the ight soil.
Result of the test shows that when feeding for 4 weeks, these article receive the calcium carbonate control group animal of height, body weight and the same calcium absorption level of examination group rat to compare there was no significant difference (P＞0.05%).These article calcium absorptivity compares also there was no significant difference (P＞0.05%) with the calcium carbonate control group that same calcium is taken in level, promptly shows to can be used as calcium-supplementing preparation.Test data sees the following form 1,2.
Table 1 receives sample to the influence () of calcium in rats absorptivity (x ± s)
Feed consumption, fecal calprotectin content are respectively 2.85 (P＜0.05) through one-way analysis of variance F value, 599.66 (P＜0.01) between each group of a
* through the Q check, conspicuousness is arranged, P＜0.05 with low calcium control group comparing difference
* checks through Q, and comparing difference with low calcium control group and calcium carbonate all has conspicuousness, P＜0.05
Table 2 receives sample to the influence (two) of calcium in rats absorptivity (x ± s)
Take in calcium, fecal calprotectin and calcium absorptivity between each group of a and be respectively 1048.63,206.91 and 71.63, be P＜0.01 through one-way analysis of variance F value
* through the Q check, conspicuousness is arranged, P＜0.05 with low calcium control group comparing difference
* checks through Q, and comparing difference with low calcium control group and calcium carbonate all has conspicuousness, P＜0.05
Above-mentioned result of the test shows that product efficacy of the present invention is definite, is a kind of good calcium-supplementing preparation, safe without toxic side effect, product quality stable homogeneous.
Embodiment two
4 parts of yak marrow powders, 1 part of bone collagen, 30 parts of coix seeds, 35 parts of Chinese yams, 8 parts in lotus seeds, 2 parts in almond, 20 parts of FOSs, 0.05 part of CPP, 1 part in ferment.With coix seed, Chinese yam, lotus seeds, almond crushing screening; Adopt the equivalent method of progressively increasing to mix with yak marrow powder, bone collagen, FOS, CPP, ferment again, adopt the can of full-automatic sterile bottle placer to get final product.
This formulation product can arrive set quality standard through check, shows that through clinical test-meal test these article can be alleviated skeleton pain, strong bone.
Embodiment three
15 parts of yak marrow powders, 5 parts of bone collagens, 18 parts of coix seeds, 25 parts of Chinese yams, 8 parts in lotus seeds, 6 parts in almond, 20 parts of FOSs, 0.8 part of CPP, 2 parts in ferment.With coix seed, Chinese yam, lotus seeds, almond crushing screening; Adopt the equivalent method of progressively increasing to mix with yak marrow powder, bone collagen, FOS, CPP, ferment again, adopt the can of full-automatic sterile bottle placer to get final product.
This formulation product can arrive set quality standard through check, shows that through clinical test-meal test these article can be alleviated skeleton pain, strong bone.
Above-mentionedly be merely several specific embodiment of the present invention, but design concept of the present invention is not limited thereto, allly utilizes this design that the present invention is carried out the change of unsubstantiality, all should belong to the behavior of invading protection domain of the present invention.
Claims (4)
1. one kind has the compound preparation that improves body immunity and enhance bone density, and it is characterized in that: the weight proportion of its active ingredient is following: yak marrow powder 2-15 part, bone collagen 0.5-5 part; Coix seed 5-35 part, Chinese yam 5-35 part, lotus seeds 2-15 part; Almond 2-8 part; FOS 5-35 part, CPP 0.01-1 part, ferment 0.01-5 part; Said ferment is selected from a kind of or its combination in starch amylase, proteolytic enzyme, lipase and the fiber amylase.
2. a kind of compound preparation that improves body immunity and enhance bone density that has as claimed in claim 1, it is characterized in that: the weight proportion of its active ingredient is following: yak marrow powder 5-10 part, bone collagen 2-5 part; Coix seed 20-30 part, Chinese yam 16-28 part, lotus seeds 6-12 part; Almond 3-8 part; FOS 16-32 part, CPP 0.05-0.5 part, ferment 0.1-3 part.
3. according to claim 1 or claim 2 a kind of has the compound preparation that improves body immunity and enhance bone density, and it is characterized in that: described compound preparation is a pulvis.
4. the application of the described compound preparation of claim 1 in the product of preparation raising body immunity and enhance bone density.
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| CN102423074B (en) * | 2011-12-20 | 2013-03-27 | 杨明华 | Nutritional and healthy health care product |
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| CN105996056A (en) * | 2016-06-02 | 2016-10-12 | 王斐芬 | Anti-aging collagen peptide powder |
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| CN109419005A (en) * | 2017-08-25 | 2019-03-05 | 王亚军 | It is a kind of replenish the calcium, the composition of bone glue of yak former peptide of hypoglycemic and preparation method thereof |
| CN107874062A (en) * | 2017-11-14 | 2018-04-06 | 王清秀 | FOS ox bone marrow peptide compound powder and its application |
| CN109221909A (en) * | 2018-10-22 | 2019-01-18 | 四川环太生物科技股份有限公司 | A kind of no seitan functional food and preparation method thereof |
| CN115399473A (en) * | 2021-05-27 | 2022-11-29 | 深圳市回春堂健康管理服务有限公司 | Yak marrow high-calcium protein powder composition for increasing bone density and preparation method thereof |
| CN114946975A (en) * | 2022-04-12 | 2022-08-30 | 王连声 | Health tea containing yak bone marrow powder and preparation process thereof |
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| CN101715912A (en) * | 2008-12-02 | 2010-06-02 | 天津天狮生物发展有限公司 | Calcium chewable tablets and manufacturing process thereof |
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| CN1179893A (en) * | 1996-09-20 | 1998-04-29 | 张士舜 | Method for producing fetid cassia tea |
| CN101715912A (en) * | 2008-12-02 | 2010-06-02 | 天津天狮生物发展有限公司 | Calcium chewable tablets and manufacturing process thereof |
| CN101785547A (en) * | 2010-03-19 | 2010-07-28 | 许勇男 | Natto nanometer calcium chewable tablets |
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