CN109043505A - The low slag nutrient formulation product of ocean fish oligopeptide, Its Preparation Method And Use - Google Patents

The low slag nutrient formulation product of ocean fish oligopeptide, Its Preparation Method And Use Download PDF

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CN109043505A
CN109043505A CN201810715676.7A CN201810715676A CN109043505A CN 109043505 A CN109043505 A CN 109043505A CN 201810715676 A CN201810715676 A CN 201810715676A CN 109043505 A CN109043505 A CN 109043505A
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nutrient formulation
formulation product
low
product
low slag
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CN109043505B (en
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冯予春
覃倩倩
刘德恽
陈璐璐
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Beijing Maifu Medical Technology Co ltd
Jilin Maifu Nutrition Technology Co ltd
Maifu Nutrition Technology Co ltd
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Jilin Mafu Nutrition Technology Co Ltd
Mai Fu Nutrition Technology (beijing) Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pediatric Medicine (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The present invention provides a kind of low slag nutrient formulation product, Its Preparation Method And Use, and the product does not add dietary fiber, is applicable to carry out intestinal inspection, the intestinal surgery patient of bowel preparation.The product includes protein, carbohydrate, fat, minerals and vitamins, using the smaller ocean fish oligopeptide substitution collagen of molecular weight, while keeping extremely low slag, the nutritional ingredient for being easier to absorb is provided, so that providing sufficient nutrition while cleaning, reducing enteron aisle production gas for patient.High through inventive article treated cleaning intestinal tract degree compared with conventional cleaning intestinal tract processing mode, enteron aisle adenoma, polyp recall rate are high, and gas production is few, and nutritional support is good, and patient's relevance grade is high.

Description

The low slag nutrient formulation product of ocean fish oligopeptide, Its Preparation Method And Use
Technical field
The present invention relates to the low slag nutrient formulation products of special medicine, Its Preparation Method And Use.
Background technique
Colorectal cancer, colorectal cancer, colorectal polypus are the enteron aisle lesion types of high risk, high incidence.
Colorectal cancer is initiated by the intraepithelial malignant tumour of Colorectal mucosa, be clinical most commonly seen malignant tumour it One.The annual colorectal cancer new cases in China are more than 250,000.It is shown according to " China's tumour registration annual report ", colorectal cancer is that China is swollen Tumor registers regional second common tumor in digestive tract in 2009, is only second to gastric cancer, and disease incidence is 29.44/10 ten thousand, the same period death rate It is 14.23/10 ten thousand, accounts for the 5th of mortality of malignant tumors.In the past 20 years, the colorectal cancer incidence rate in China rises in lasting Trend, colon cancer morbidity increase obviously, and the carcinoma of the rectum is basicly stable.Currently, China's Colorectal Cancer number and death toll account for generation The 18%-20% of boundary's same period.
Colorectal cancer is also common one of the malignant tumour in China, it is considered that the generation of most colorectal cancers derives from gland Stem cell, that is, denove cancer of large intestine normal mucosa centrum germinativum, such as IIc lesion are directly originated from the cancer of tumor, part.
Colorectal polypus refer to the lesion swelled in oriented enteric cavity.The incidence various countries of colorectal polypus are different, total Colonoscopy recall rate is 10%~20%.Its disease incidence increases with the growth at age, with adenomatous polyp be it is common, account for about 70%.If enteral polyp is not found and treats for a long time, hematochezia and stool abnormity, entembole, intestines prolapsus even cancer will lead to Become.
Therefore, timely, accurate diagnosis and treatment are needed to above-mentioned enteric disorders.It is general with digestive endoscopy technology clinical application And effect of the endoscopies such as Sigmoidoscope, the enteroscope and capsule endoscope form in intestines problem diagnosis and treatment becomes increasingly conspicuous.With colon Mirror is that the screening means of representative can effectively prevent the generation of colorectal cancer, and its case fatality rate is relatively expected to reduce by 53%.? The U.S., total colonoscopy have become the first-selected instrument of 50 years old or more white man's average risk Mass screening colorectal cancer.Meanwhile it tying Colonoscopy is also the most strong detection methods for diagnosing polyp of colon.And in the diagnosis of colorectal cancer, endoscopy also has various at present The advantage that iconography can not replace can not only intuitively find colorectal mucosa early lesion, and can be by biopsy to lesion Histological evaluation is carried out, can further improve the recall rate and diagnosis of early carcinoma and precancerous lesion.
And in endoscopy, INTESTINAL CLEANSING quality directly affects the treatment effect of scope.Using Sigmoidoscope as representative, colon 2 key indexes of spectroscopy quality be cecal intubation rate and adenoma recall rate, it is related to gut purge quality.INTESTINAL CLEANSING quality It is the Key determining factors of the quality of Sigmoidoscope, difficulty, speed and completeness, determines the accuracy of colon-endoscope diagnosis and control The safety for the treatment of, the abundant degree of gut purge are most important to the effect of colonoscopy.
For a long time, the ineffective problem of scope caused by INTESTINAL CLEANSING is insufficient is very prominent.According to statistics, enteron aisle is quasi- Standby insufficient ratio is 20%~30% (HarewoodgC, Sharma VK, degarmo P.Gastrointest Endosc, 2003,58 (1): 76-79.Hassan C, et al；European Society ofgastrointestinal Endoscopy.Endoscopy, 2013,45 (2): 142-150.Liu X, Luo H, Zhang L, et al.Gut, 2014,63 (1): 125-130.).The insufficient consequence of INTESTINAL CLEANSING has:
(1) lesion is omitted.The insufficient patient's polyp of INTESTINAL CLEANSING and adenoma omit risk increase to 3 times (Hong SN, Sung IK, Kim JH, et al.Clin Endosc, 2012,45 (4): 404-411.).
(2) colonoscopy inspection is repeated.The insufficient patient's microscopy failure rate of INTESTINAL CLEANSING obviously increases, and needs to repeat gut purge microscopy (Chokshi RV,et al.gastrointest Endosc.2012,75(6):1197-203.Lebwohl B,et al.gastrointest Endosc.2011,73(6):1207-14.)。
(3) the colonoscopy operating time increases.The Sigmoidoscope operating time (reaches caecum time, colonoscopy Withdrawal Hour, whole process Time) it is significant related to gut purge quality.The gut purge low-quality Sigmoidoscope operating time is apparently higher than the middle and high patient of gut purge quality (the arrival caecum time is respectively 16.1,14.4,11.9 minutes；Colonoscopy Withdrawal Hour is respectively 11.3,11.1,9.8 minutes；It is whole A process time is respectively 27.4,25.6,21.7 minutes) (Froehlich F, Wietlisbach V, Gonvers JJ, et Al.Gastrointest Endosc, 2005,61 (3): 378-384.).
(4) colonoscopy operation difficulty increases.INTESTINAL CLEANSING is insufficient to cause operation difficulty to increase by 21.8%: gut purge is low-quality Sigmoidoscope operating difficulties rate is significantly higher than person in gut purge quality height and gut purge quality；Sigmoidoscope operates compared with the high person of gut purge quality Difficulty increases by 21.8%, and difference has statistical significance (Froehlich F, Wietlisbach V, Gonvers JJ, et Al.Gastrointest Endosc, 2005,61 (3): 378-384.).
(5) colonoscopy operation cannot often be completed.INTESTINAL CLEANSING is insufficient to lead to Sigmoidoscope operation completion rate decline 19.3%: clear The low-quality Sigmoidoscope operation completion rate of intestines is substantially less than person in gut purge quality height and gut purge quality；Compared with the high person of gut purge quality Sigmoidoscope operate completion rate decline 19.3%, difference have statistical significance (Froehlich F, Wietlisbach V, Gonvers JJ, et al.Gastrointest Endosc, 2005,61 (3): 378-384.).
(6) inspection fee increases.INTESTINAL CLEANSING is insufficient to cause microscopy expense to increase, under the conditions of ideal INTESTINAL CLEANSING Colonoscopy is compared, and private hospital and public hospital's expense have increased separately 11.8% and 21.5%.(Rex DK, Imperiale TF, Latinovich DR, et al.Am Jgastroenterol, 2002,97 (7): 1696-1700.).
Therefore, angle is diagnosed from colonoscopy, cleaning intestinal tract degree there are accurate diagnosis and treatment important meaning.
And from enteropathy operative treatment angle, preoperative bowel preparation is also particularly important to the smooth implementation of intestinal surgery 's.Preoperative INTESTINAL CLEANSING can remove excrement in enteron aisle, reduce bacterial number in enteron aisle, reduce anastomotic leakage, abdominal cavity infection, wound Schistostoma such as opens at the generation of complication.
To sum up, either in colonoscopy diagnosis and treatment stage or intestinal surgery treatment stage, the importance of cleaning intestinal tract is not all allowed Ignore.Currently used INTESTINAL CLEANSING method include enema and oral purgative method (such as mannitol, magnesium sulfate, electrolytic liquid, Folium sennae etc.).These methods can obtain relatively satisfactory effect to most of knots, rectal cancer surgery patient, but also have disadvantage and not Foot.Because enema or oral purgative itself will bring electrolyte disturbance, nutriment to be lost serious, Patient Experience difference etc. and ask Topic, and preoperative 3 days dietary restrictions are required to before bowel lavage and oral purgative, proteins,vitamins,minerals etc. will be caused various The insufficiency of intake of nutrient and energy weakens the ability of defence infection to influence tissue repair and Wound healing.Meanwhile machine Body was in starvation in 3 days, led to patient's intestinal mucosa atrophy, mucosal barrier function damage, and it is thin to increase enteron aisle for flora imbalance The incidence of bacterium displacement, increases enterogenic infection chance.Since intestinal mucosa absorption function weakens, nutrient malabsorption or electricity are caused It is unbalance to solve matter, in addition dehydration and malnutrition occurs in the influence of disease itself, thus reduces patient to the tolerance of operation.
In view of the above-mentioned problems, at present clinically generally before bowel lavage or oral purgative, with Parenteral Nutrition preparation or commonly Ancillary measure of the liquid diet as INTESTINAL CLEANSING, to feed demand of the patient to nutrition.However, current enteral nutrition preparation It is unable to satisfy the demand, solves described problem, reason is:
(1) nutritional ingredient is not comprehensive, cannot play full nutrition support.
If CN105795481A discloses tailored version nutritional supplement before a kind of intestinal canal operation, maltodextrin, glutamy are included Amine and sodium potassium ion.The formula nutritional ingredient is single, lacks dimension minerals and fat, nutrient be not comprehensive.
(2) content of cellulose is not low enough, and cleaning intestinal tract degree cannot reach requirement.
If CN107951015A discloses a kind of full nutrient formulation powder and preparation method thereof, the formula is fine containing diet Dimension, is not suitable for bowel preparation.CN103431391A discloses a kind of comprehensive nutrition powder formula, contains zein fiber Powder is not suitable for bowel preparation.
(3) it is not easy to absorb, enteron aisle is easy to cause to produce inflatable gas, so that enteron aisle bubble increases, improve colonoscopy operation difficulty.
If CN1290443C describes a kind of enteral total nutrient emulsion, which is primarily adapted for use in nutritious intake obstacle Patient, its protein component, which are mainly derived from, absorbs relatively slow, higher cost casein preparation, and nutriment is not easy to absorb, and easily Produce inflatable gas.
Summary of the invention
In view of the deficiencies of the prior art, for the present invention by research, production, which has been prepared, is specially adapted for enteron aisle microscopy, intestinal canal operation The low slag nutrient formulation product of preceding preparation and post-operative recovery.Product (1) content of cellulose is extremely low, and cleaning intestinal tract effect is good, energy Improve enteroscopy success rate, effectively avoid failing to pinpoint a disease in diagnosis with rechecking, reduce cost；(2) without the plant food source for being easy production gas Ingredient effectively avoids intestinal tract flatulence, and the bubble reduced in enteroscopy generates, and improves intestines and examines accuracy；(3) selected to be easier to by The albumen that body absorbs, comprehensively, Patient Experience is good, and adverse reaction is few, and post-operative recovery is fast for nutrient formulation science.
In particular it relates to:
(1) a kind of low slag nutrient formulation product, which is characterized in that contain following component: protein, carbohydrate, rouge Fat, vitamin and mineral.
(2) low slag nutrient formulation product described in above-mentioned (1), in every 100g product, dietary fiber content be 1.2g with Under.
(3) low slag nutrient formulation product described in above-mentioned (1) or (2), wherein the protein be ocean fish oligopeptide and/ Or rice protein.
(4) low slag nutrient formulation product described in any one of above-mentioned (1) to (3) in every 1000g product, contains The ocean fish oligopeptide 140-240g, and/or rice protein 22-37g.
(5) low slag nutrient formulation product described in any one of above-mentioned (1) to (4), wherein the carbohydrate is Maltodextrin and/or fructose.
(6) low slag nutrient formulation product described in any one of above-mentioned (1) to (5) in every 1000g product, contains The maltodextrin 80-120g, and/or fructose 170-290g.
(7) low slag nutrient formulation product described in any one of above-mentioned (1) to (6), wherein the fat is selected from jade It is at least two kinds of in rice bran oil, sunflower oil, soybean oil, rapeseed oil, coconut oil and medium chain triglyceride.
(8) low slag nutrient formulation product described in any one of above-mentioned (1) to (7) in every 1000g product, contains The fat 230-400g.
(9) low slag nutrient formulation product described in any one of above-mentioned (1) to (8), wherein the fat is by low albumen Fatty powder provides.
(10) low slag nutrient formulation product described in above-mentioned (9) in every 1000g product, contains the low albumen fat Powder 230-400g.
(11) low slag nutrient formulation product described in any one of above-mentioned (1) to (8), wherein with 4-6 in the fat: The mass ratio of 2-4 contains vegetable fat and medium chain triglyceride.
(12) low slag nutrient formulation product described in above-mentioned (11), wherein the vegetable fat by corn oil, sunflower oil, Soybean oil, rapeseed oil and coconut oil composition.
(13) low slag nutrient formulation product described in above-mentioned (12), wherein the corn oil, sunflower oil, soybean oil, dish The mass ratio of seed oil and coconut oil is 28-32:18-22:18-22:18-22:6-9.
(14) low slag nutrient formulation product described in any one of above-mentioned (1) to (13), wherein the vitamin is choosing From L-AA sodium, niacinamide, folic acid, dl- α-D-α-tocopherol acetate, D-VB5 calcium, riboflavin, puridoxine hydrochloride, hydrochloric acid sulphur It is at least two kinds of in amine element, retinol acetate, Vitamin D3, phytondione, cyanocobalamin and D-Biotin.
(15) low slag nutrient formulation product described in above-mentioned (14), in every 1000g product, the content point of the vitamin Not are as follows: L-AA sodium: 0.6-1.8g, niacinamide: 0.1-0.25g, folic acid: 0.001-0.003g, dl- α-tocopherol acetate Phenol: 0.23-0.55g, D-VB5 calcium: 0.05-0.12g, riboflavin: 0.09-0.22g, puridoxine hydrochloride: 0.15-0.34g, salt Allithiamine element: 0.01-0.028g, retinol acetate: 0.03-0.07g, Vitamin D3: 0.015-0.034g, phytondione: 0.0004-0.0009g, cyanocobalamin: 0.00004-0.00009g, D-Biotin: 0.00007-0.00018g.
(16) low slag nutrient formulation product described in any one of above-mentioned (1) to (15), wherein the minerals are choosings From at least two kinds of in ferrous sulfate, zinc sulfate, magnesium sulfate, calcium carbonate, preferably these minerals are embedded with embedding medium.
(17) low slag nutrient formulation product described in above-mentioned (16), in every 1000g product, the content point of the minerals Not are as follows: ferrous sulfate: 0.08-0.25g, zinc sulfate: 0.08-0.22g, magnesium sulfate: 7-17g, calcium carbonate: 1.2-2.9g.
(18) low slag nutrient formulation product described in any one of above-mentioned (1) to (17), wherein further containing food Additive.
(19) low slag nutrient formulation product described in above-mentioned (18), wherein the food additives are that thickening agent carboxymethyl is fine Tie up plain sodium.
(20) low slag nutrient formulation product described in above-mentioned (19) in every 1000g product, contains the carboxymethyl cellulose Plain sodium 10-18g.
(21) low slag nutrient formulation product described in any one of above-mentioned (1) to (20), wherein the protein is sea Foreign fish oligopeptide and/or rice protein；The carbohydrate is maltodextrin and/or fructose；The fat is selected from corn It is at least two kinds of in oil, sunflower oil, soybean oil, rapeseed oil, coconut oil and medium chain triglyceride；The vitamin is selected from L- Sodium ascorbate, niacinamide, folic acid, dl- α-D-α-tocopherol acetate, D-VB5 calcium, riboflavin, puridoxine hydrochloride, thiamine hydrochloride, It is at least two kinds of in retinol acetate, Vitamin D3, phytondione, cyanocobalamin and D-Biotin；The minerals are selected from sulphur It is sour ferrous iron, zinc sulfate, magnesium sulfate, at least two kinds of in calcium carbonate；It is optionally also added containing food in the nutrient formulation product Agent.
(22) low slag nutrient formulation product described in above-mentioned (21), wherein containing ocean fish oligopeptide, rice protein, malt Dextrin, fructose, corn oil, sunflower oil, soybean oil, rapeseed oil, coconut oil, medium chain triglyceride, L-AA sodium, nicotinoyl Amine, folic acid, dl- α-D-α-tocopherol acetate, D-VB5 calcium, riboflavin, puridoxine hydrochloride, thiamine hydrochloride, retinol acetate, gallbladder calcium Change alcohol, phytondione, cyanocobalamin, D-Biotin, ferrous sulfate, zinc sulfate, magnesium sulfate, calcium carbonate and optionally adds Food additives such as sodium carboxymethylcellulose.
(23) low slag nutrient formulation product described in above-mentioned (22) in every 1000g product, contains ocean fish oligopeptide 140-240g, rice protein 22-37g, maltodextrin 80-120g, fructose 170-290g, fat 230-400g, L-AA Sodium 0.6-1.8g, niacinamide 0.1-0.25g, folic acid 0.001-0.003g, dl- α-D-α-tocopherol acetate 0.23-0.55g, D-VB5 Calcium 0.05-0.12g, riboflavin 0.09-0.22g, puridoxine hydrochloride 0.15-0.34g, thiamine hydrochloride 0.01-0.028g, acetic acid Retinyl ester 0.03-0.07g, Vitamin D3 0.015-0.034g, phytondione 0.0004-0.0009g, cyanocobalamin 0.00004- 0.00009g, D-Biotin 0.00007-0.00018g, ferrous sulfate 0.08-0.25g, zinc sulfate 0.08-0.22g, magnesium sulfate 7-17g, calcium carbonate 1.2-2.9g and the thickener sodium carboxymethylcellulose 10-18g optionally added；It is preferred that the fat contains plant Object grease and medium chain triglyceride, the vegetable fat are made of corn oil, sunflower oil, soybean oil, rapeseed oil and coconut oil.
(24) low slag nutrient formulation product described in above-mentioned (23), wherein the quality of vegetable fat and medium chain triglyceride Than for 4-6:2-4, the corn oil, sunflower oil, soybean oil, rapeseed oil and coconut oil mass ratio be 28-32:18-22: 18-22:18-22:6-9。
(25) low slag nutrient formulation product described in above-mentioned (23) or (24) is low containing marine fish in every 1000g product Poly- peptide 170-210g, rice protein 26-33g, maltodextrin 95-120g, fructose 225-250g, low albumen fatty powder 320- 370g, L-AA sodium 1.1-1.7g, niacinamide 0.13-0.23g, folic acid 0.0013-0.0023g, dl- α-D-α-tocopherol acetate 0.3-0.5g, D-VB5 calcium 0.07-0.1g, riboflavin 0.1-0.17g, puridoxine hydrochloride 0.2-0.25g, thiamine hydrochloride 0.012-0.02g, retinol acetate 0.03-0.06g, Vitamin D3 0.02-0.03g, phytondione 0.0004-0.0007g, Cyanocobalamin 0.00004-0.00007g, D-Biotin 0.00008-0.00016g, ferrous sulfate 0.1-0.2g, zinc sulfate 0.1- 0.2g, magnesium sulfate 11-15g, calcium carbonate 1.8-2.2g and the thickener sodium carboxymethylcellulose 13-16g optionally added.
(26) low slag nutrient formulation product described in any one of above-mentioned (23) to (25), every 1000g is low, and slag nutrition is matched In square product, contain ocean fish oligopeptide 205-210g, rice protein 30-33g, maltodextrin 100-118g, fructose 235- 250g, low albumen fatty powder 340-360g, L-AA sodium 1.2-1.6g, niacinamide 0.18-0.2g, folic acid 0.0017- 0.002g, dl- α-D-α-tocopherol acetate 0.35-0.45g, D-VB5 calcium 0.07-0.08g, riboflavin 0.1-0.14g, hydrochloric acid pyrrole are trembled Alcohol 0.2-0.25g, it thiamine hydrochloride 0.012-0.02g, retinol acetate 0.04-0.05g, Vitamin D3 0.02-0.03g, plants Object menadione 0.0005-0.0006g, cyanocobalamin 0.00005-0.00006g, D-Biotin 0.0001-0.00012g, sulfuric acid are sub- Iron 0.15-0.2g, zinc sulfate 0.15-0.18g, magnesium sulfate 13-14g, calcium carbonate 1.8-2.0g and the thickener optionally added Sodium carboxymethylcellulose 13-16g.
(27) preparation method of low slag nutrient formulation product described in any one of above-mentioned (1) to (26) comprising with Lower step: (1) it pre-processes, (2) weigh, (3) pulverize and sieve, (4) just mix (5) total mix.
(28) method described in above-mentioned (27), wherein step (1) pre-treatment step is by each raw material and the food optionally employed Product additive irradiates 2 hours respectively to carry out disinfection.
(29) method described in above-mentioned (27) or (28), wherein step (3) pulverize and sieve be respectively by each raw material and optionally The food additives used cross the sieve of 100 mesh or more.
(30) method described in any one of above-mentioned (27) to (29), the condition that wherein step (4) is just mixed are as follows: will be various Vitamin, various minerals, rice protein and the food additives optionally employed such as sodium carboxymethylcellulose are by weighing Amount just mixed 10~20min is carried out not higher than 28 DEG C and in environment of the humidity no more than 65% in temperature, until uniformly.
(31) method described in any one of above-mentioned (27) to (30), the wherein condition of step (5) total mix are as follows: by malt Dextrin, ocean fish oligopeptide, fructose and fat press load weighted amount, are added separately to first mixing obtained in above-mentioned steps (4) In, 20~40min, preferably 30min are mixed not higher than 28 DEG C and in environment of the humidity no more than 65% in temperature, until uniformly.
(32) use of the low slag nutrient formulation product in bowel preparation described in any one of above-mentioned (1) to (26) On the way.
(33) low slag nutrient formulation product described in above-mentioned (32) is preparing the purposes in bowel preparation product.
(34) purposes described in above-mentioned (32) or (33), the bowel preparation are in Sigmoidoscope, small intestine Bowel preparation before mirror, endoscopic ultrasonography or Capsule Endoscopy.
(35) purposes described in above-mentioned (32) or (33), the bowel preparation are clear in the preoperative enteron aisle of intestinal surgery Clean preparation.
(36) purposes described in above-mentioned (35), the surgical operation include colorectal neoplasm operation, radical resection for colorectal cancer, Quan Jie Enterectomy, the operation of laparoscope lower gastrointestinal tract, Pancreatoduodenectomy, small intestine wide excision, partial enterectomy, Intestines stoma (fistula) Closure.
(37) purposes described in any one of above-mentioned (32) to (36), wherein the bowel preparation is will be described Low slag nutrient formulation product is edible as early, middle and late breakfast, lunch and dinner, and every meal dosage is 120-180g.
(38) low slag nutrient formulation product described in any one of above-mentioned (1) to (26) is in the postoperative battalion of intestinal surgery Support the purposes in supporting.
(39) purposes described in above-mentioned (38), intestinal surgery operation include colorectal neoplasm operation, radical resection for colorectal cancer, Pancolectomy, the operation of laparoscope lower gastrointestinal tract, Pancreatoduodenectomy, small intestine wide excision, small intestine are cut Except art, intestines stoma (fistula) Closure.
Specific embodiment
In a first aspect, the present invention provides a kind of low slag nutrient formulation product for being exclusively used in bowel preparation, the product Contain following component: protein, carbohydrate, fat, vitamin and mineral.
In the present invention, the content of above each ingredient fully take into account the specific crowd that needs to carry out bowel preparation for The special low slag of food easily absorbs, comprehensive nutritional need.
Next coming in order are illustrated above-mentioned each ingredient.
(1) protein
In a preferred embodiment, the protein in inventive article includes ocean fish oligopeptide and/or rice protein.
Ocean fish oligopeptide is the high-quality oligopeptide extracted from the high protein fingerling skin at remote deep-sea, pure pollution-free, no Containing substances such as hormone, preservative, antibiotic, pigments, any preservative is not added in not fatty and carbohydrate, keeps 100% Pure natural characteristic.
In the present invention, ocean fish oligopeptide can be provided by ocean fish oligopeptide powder, marine oligopeptide powder be with ocean fish-skin, Fish-bone or the flesh of fish are raw material, and oligopeptide (small peptide) of produced with the enzymatic isolation method, relative molecular mass lower than 1000u is main component Powdery product (referring to GB/T22729-2008).Such ocean fish oligopeptide powder dissolubility is good, can be rapid under room temperature Water is dissolved, forms evenly dispersed solution, absorptivity is up to 95% or more.
Total amino acid content reaches 100% in the fish oligopeptide of ocean, and sulfur-containing amino acid methionine accounts for total amino acid content 3.8%, the hydrophobic amino acid in addition to methionine accounts for the 26.7% of total amino acid content.Therefore, with the amino of antioxidant activity Acid accounts for 30.5% in total.
Ocean fish oligopeptide total amount of essential amino acids are high, A wide selection of colours and designs, especially threonine, valine, leucine and rely The content of propylhomoserin is very high, therefore ocean fish oligopeptide can be used as the hardening agent or efficient functional food additives of amino acid.
In the prior art, conventional animal albumen casein is as protein, but casein is whole albumen, it is more difficult to be inhaled by body It receives.The ocean fish oligopeptide that the present invention chooses is easier to be absorbed.
In the present invention, ocean fish oligopeptide is selected rather than common collagen as main albumen source is also conduct Inhibit to produce one of gas measure.Common collagen molecules amount is big, is not easy to be digested and assimilated by body, protein utilization is low.This hair The ocean fish oligopeptide of bright selection belongs to animal protein, produces the gas factor without any oligosaccharide similar to vegetable protein sources, The content of its dietary fiber is also below detection lower limit.Therefore, the present invention selects ocean fish oligopeptide as albumen main source, energy Intestinal tract flatulence caused by food-borne production gas is enough reduced, so that bubble when enteron aisle microscopy is on the one hand effectively reduced generates, on the one hand Recovery after being also beneficial to polyp surgery improves microscopy quality, promotes postoperation recovery.
In the present invention, rice protein is also can be used in protein.The biological value (B.V.) and protein score, PS of rice protein (P.V.) higher than other oroteins, nutritive value is high, and the amino acid Compositional balance of rice protein is reasonable, amino acid content Height is easy to absorb, is that other albumen are incomparable, bad especially suitable for enteron aisle digestion, absorption function, to nutritional need height Crowd.In addition, rice protein is low antigenic type albumen, allergic reaction will not be generated, therefore be also applied for infant and allergy Patient.Meanwhile rice protein not only has unique trophic function, there are also some other healthcare functions, such as can reduce serum The content of cholesterol.
Arrange in pairs or groups simultaneously in preferred embodiment, in nutrient formulation product of the invention using ocean fish oligopeptide and Rice protein, egg-pair white matter formula design in this way, so that the content and balanced proportion, egg of the essential amino acid in formula White nutrition is more comprehensively balanced, and the enteron aisle especially suitable for digestion, malabsorption is to be checked and to patient with operation, is providing enteron aisle Also there are certain health care functions while cleaning preparation, nutritional support.
Preferably, fish oligopeptide 140-240g in ocean is contained in the low every 1000g of slag nutrient formulation product of the invention, it is more excellent Select 170-210g, still more preferably 205-210g.
Preferably, rice protein 22-37g, more preferable 26- are contained in the low every 1000g of slag nutrient formulation product of the invention 33g, still more preferably 30-33g.
(2) carbohydrate
In low slag nutrient formulation product of the invention, the carbohydrate is preferably maltodextrin and/or fructose.
Preferably, maltodextrin 80-120g, more preferable 95- are contained in the low every 1000g of slag nutrient formulation product of the invention 120g, still more preferably 100-118g.
Preferably, fructose 170-290g, more preferable 225- are contained in the low every 1000g of slag nutrient formulation product of the invention 250g, still more preferably 235-250g.
(3) fatty
It in a preferred embodiment, include following component for the fat in the low slag nutrient formulation product of the present invention In it is at least two kinds of: corn oil, sunflower oil, soybean oil, rapeseed oil, coconut oil and medium chain triglyceride.
In preferred embodiment, the fat preferably comprises vegetable fat and medium chain triglyceride, the two quality Than for 4-6:2-4, more preferably 5:3.The vegetable fat can be by corn oil, sunflower oil, soybean oil, rapeseed oil and coconut Oil 28-32:18-22:18-22:18-22:6-9 in mass ratio composition, more preferable mass ratio are 31:21.5:20:19:8.5.
In further preferred embodiment, preferably using low albumen fatty powder as adipose-derived, more preferable use length The very high low albumen fatty powder of chain unsaturated fatty acid (linoleic acid and alpha-linolenic acid) content, such as long-chain unsaturated fatty acid account for Low albumen fatty powder more than 24% (mass ratio) of total fatty acids amount can make the length of the low slag nutrient formulation product of the present invention in this way Chain unsaturated fatty acid content is much higher than other enteral total nutrient products.Commercially available product can be used in such low albumen fatty powder, Such as it can be purchased from safe scientific and technological (Qingdao) limited liability company of U.S..
Linoleic acid contains 2 unsaturated fat keys, has anticancer, antiatherosclerosis, enhancing immunity of organisms, inhibits Fat Accumulation and weight-reducing reduce the physiological functions such as cholesterol, enhancing development.Alpha-linolenic acid be constitute human tissue cell and The basic substance of biological enzyme can be synthesized in vivo, be metabolized, being converted into vital activity factor D HA and EPA necessary to body, this two Kind of substance in vivo can reducing blood lipid, improve blood circulation, inhibit platelet aggregation, suppress atherosclerotic plaque and thrombus It is formed.Linoleic acid and alpha-linolenic acid are the essential fatty acid that human body itself cannot synthesize, need food-borne supply.Of the invention It is preferred that in nutrient formulation product, linoleic acid and the high low albumen fatty powder of alpha-linolenic acid content are added as lipid nutrition source, is made It is healthier to obtain the product trophic structure, and more extensive using crowd.
Preferably, fat 230-400g, more preferable 320- are contained in the low every 1000g of slag nutrient formulation product of the invention 370g, still more preferably 340-360g.
When using low albumen fatty powder as lipid nutrition source, contain in the low every 1000g of slag nutrient formulation product of the invention There are low albumen fatty powder 230-400g, more preferable 320-370g, still more preferably 340-360g.
(4) vitamin
In a preferred embodiment, the vitamin in the low slag nutrient formulation product of the present invention contains in following component It is at least two kinds of: L-AA sodium, niacinamide, folic acid, dl- α-D-α-tocopherol acetate, D-VB5 calcium, riboflavin, hydrochloric acid pyrrole are trembled Alcohol, thiamine hydrochloride, retinol acetate, Vitamin D3, phytondione, cyanocobalamin and D-Biotin.
Vitamin of the invention contains the vitamin of at least two kinds of needed by human body, can help the undesirable enteron aisle hand of function of intestinal canal Art patient restores, and can improve immunity of organisms, epithelial cell is protected and repaired, and easily loses in supplement operation or wound B family vitamin, such as vitamin B1、B2, niacin and pantothenic acid, to improve physical function.Dosage and limit of the present invention to vitamin Amount is stringent to be calculated, scientific matching.
Preferably, in the low every 1000g of slag nutrient formulation product of the invention, the content of said vitamin is respectively as follows:
L-AA sodium: 0.6-1.8g, more preferable 1.1-1.7g, still more preferably 1.2-1.6g；
Niacinamide: 0.1-0.25g, more preferable 0.13-0.23g, still more preferably 0.18-0.2g；
Folic acid: 0.001-0.003g, more preferable 0.0013-0.0023g, still more preferably 0.0017-0.002g；
Dl- α-D-α-tocopherol acetate: 0.23-0.55g, more preferable 0.3-0.5g, still more preferably 0.35-0.45g；
D-VB5 calcium: 0.05-0.12g, more preferable 0.07-0.1g, still more preferably 0.07-0.08g；
Riboflavin: 0.09-0.22g, more preferable 0.1-0.17g, still more preferably 0.1-0.14g；
Puridoxine hydrochloride: 0.15-0.34g, more preferable 0.2-0.25g；
Thiamine hydrochloride: 0.01-0.028g, more preferable 0.012-0.02g；
Retinol acetate: 0.03-0.07g, more preferable 0.03-0.06g, still more preferably 0.04-0.05g；
Vitamin D3: 0.015-0.034g, more preferable 0.02-0.03g；
Phytondione: 0.0004-0.0009g, more preferable 0.0004-0.0007g, still more preferably 0.0005- 0.0006g；
Cyanocobalamin: 0.00004-0.00009g, more preferable 0.00004-0.00007g, still more preferably 0.00005- 0.00006g；
D-Biotin: 0.00007-0.00018g, more preferable 0.00008-0.00016g, still more preferably 0.0001- 0.00012g。
(5) minerals
In a preferred embodiment, the minerals in the low slag nutrient formulation product of the present invention contain in following component It is at least two kinds of: ferrous sulfate, zinc sulfate, magnesium sulfate and calcium carbonate.
Especially supplement minerals zinc in the minerals of the low slag nutrient formulation product of the present invention, zinc be a variety of enzymes composition at Point, the amount lost of zinc is serious after operation, needs that zinc is replenished in time after intestinal canal operation, not only promotes metabolism immune, but also can also accelerate skin Skin wound healing.In addition, also containing calcium, iron and magnesium in the low slag nutrient formulation product of the present invention, these are that human body is postoperative required Important minerals element.
Preferably, in the low every 1000g of slag nutrient formulation product of the invention, the content of above-mentioned minerals is respectively as follows:
Ferrous sulfate: 0.08-0.25g, more preferable 0.1-0.2g, further preferred 0.15-0.2g；
Zinc sulfate: 0.08-0.22g, more preferable 0.1-0.2g, further preferred 0.15-0.18g；
Magnesium sulfate: 7-17g, more preferable 11-15g, further preferred 13-16g；
Calcium carbonate: 1.2-2.9g, more preferable 1.8-2.2g, further preferred 1.8-2.0g.
It is used it is highly preferred that above-mentioned minerals are embedded with embedding medium after mixing.
(6) other ingredients
In low slag nutrient formulation product of the invention, food additives, such as sodium carboxymethylcellulose are also optionally added.
When adding sodium carboxymethylcellulose, in the low every 1000g of slag nutrient formulation product of the invention, content is preferably 10-18g, more preferably 13-16g.
In order to reach good cleaning intestinal tract degree, the present invention does not add dietary fiber, and strict control raw material itself additionally The dietary fiber content brought into.The dietary fiber sources that raw material is brought into are in rice protein, maltodextrin and fructose.Present invention control Dietary fiber content in every 100g product is within 1.2g.According to the requirement (referring to table 1) of food labelling regulation, claim containing The range of dietary fiber is >=3g/100g, claims that without dietary fiber be 0%, and inventive article is to improve cleaning intestinal tract degree, will Dietary fiber control is far below claiming the percentage composition limit containing dietary fiber or less.
Table 1: food labelling regulation
In intestinal inspection, other than cleaning intestinal tract degree, increased air bubble caused by flatulence is also by extreme influence colonoscopy It checks on the quality.In order to avoid intestinal tract flatulence, bubble formation is reduced, needs to add defoaming agent (such as Simethicone) clinically to reduce Bubble generates.And the food-borne gas that produces is the major reason for causing flatulence, therefore the present invention is to reduce food-borne production gas, is fully considered Each food-borne production gas factor is simultaneously inhibited.
It is that the present invention inhibits to produce gas measure first is that the content of strict control dietary fiber 1.2% hereinafter, because of cellulose It is to cause to produce one of gas reason, by inhibiting dietary fiber content, while achievees the purpose that extremely low slag, inhibiting to produce gas.
Further, in specific preferred embodiment, low slag nutrient formulation product of the invention contains following component: Ocean fish oligopeptide, rice protein, maltodextrin, fructose, low albumen fatty powder, L-AA sodium, niacinamide, folic acid, dl- α-D-α-tocopherol acetate, D-VB5 calcium, riboflavin, puridoxine hydrochloride, thiamine hydrochloride, retinol acetate, Vitamin D3, plant first Naphthoquinones, cyanocobalamin, D-Biotin, ferrous sulfate, zinc sulfate, magnesium sulfate, calcium carbonate and the food additives optionally added, such as Sodium carboxymethylcellulose.
In more specific preferred embodiment, contain in the low every 1000g of slag nutrient formulation product of the invention: marine fish Oligopeptide 140-240g, rice protein 22-37g, maltodextrin 80-120g, fructose 170-290g, fat 230-400g, L- are anti- Bad hematic acid sodium 0.6-1.8g, niacinamide 0.1-0.25g, folic acid 0.001-0.003g, dl- α-D-α-tocopherol acetate 0.23-0.55g, D-VB5 calcium 0.05-0.12g, riboflavin 0.09-0.22g, puridoxine hydrochloride 0.15-0.34g, thiamine hydrochloride 0.01- 0.028g, retinol acetate 0.03-0.07g, Vitamin D3 0.015-0.034g, phytondione 0.0004-0.0009g, cyanogen Cobalt amine 0.00004-0.00009g, D-Biotin 0.00007-0.00018g, ferrous sulfate 0.08-0.25g, zinc sulfate 0.08- 0.22g, magnesium sulfate 7-17g, calcium carbonate 1.2-2.9g and the sodium carboxymethylcellulose 10-18g optionally added.
It is highly preferred that containing in the low every 1000g of slag nutrient formulation product of the invention: ocean fish oligopeptide 170-210g, Rice protein 26-33g, maltodextrin 95-110g, fructose 225-250g, fat 320-370g, L-AA sodium 1.1- 1.7g, niacinamide 0.13-0.23g, folic acid 0.0013-0.0023g, dl- α-D-α-tocopherol acetate 0.3-0.5g, D-VB5 calcium 0.07-0.1g, riboflavin 0.1-0.17g, puridoxine hydrochloride 0.2-0.25g, thiamine hydrochloride 0.012-0.02g, acetic acid view are yellow Ester 0.03-0.06g, Vitamin D3 0.02-0.03g, phytondione 0.0004-0.0007g, cyanocobalamin 0.00004- 0.00007g, D-Biotin 0.00008-0.00016g, ferrous sulfate 0.1-0.2g, zinc sulfate 0.1-0.2g, magnesium sulfate 11- 15g, calcium carbonate 1.8-2.2g and the sodium carboxymethylcellulose 13-16g optionally added.
It is highly preferred that containing in the low every 1000g of slag nutrient formulation product of the invention: ocean fish oligopeptide 205-210g, Rice protein 30-33g, maltodextrin 100-118g, fructose 235-250g, fat 340-360g, L-AA sodium 1.2- 1.6g, niacinamide 0.18-0.2g, folic acid 0.0017-0.002g, dl- α-D-α-tocopherol acetate 0.35-0.45g, D-VB5 calcium 0.07-0.08g, riboflavin 0.1-0.14g, puridoxine hydrochloride 0.2-0.25g, thiamine hydrochloride 0.012-0.02g, acetic acid view are yellow Ester 0.04-0.05g, Vitamin D3 0.02-0.03g, phytondione 0.0005-0.0006g, cyanocobalamin 0.00005- 0.00006g, D-Biotin 0.0001-0.00012g, ferrous sulfate 0.15-0.2g, zinc sulfate 0.15-0.18g, magnesium sulfate 13- 14g, calcium carbonate 1.8-2.0g and optional sodium carboxymethylcellulose 13-16g.
Second aspect, the present invention provide a kind of method for preparing low slag nutrient formulation product.The method includes following steps It is rapid: (1) to pre-process, (2) weigh, (3) pulverize and sieve, (4) just mix (5) total mix.
One of preferably, step (1) pre-treatment step is with ultraviolet lamp by each raw material and the food optionally employed Additive irradiates 2 hours respectively to carry out disinfection.
Preferably two, it is respectively by each raw material and the food additives optionally employed that step (3), which pulverizes and sieves, Cross the sieve of 100 mesh or more.
Preferably three, the first silver mixing part of step (4) are as follows: by various vitamins, various minerals, rice protein with And the food additives optionally employed by load weighted amount temperature not higher than 28 DEG C and in environment of the humidity no more than 65% into Row just mixes 10~20min, until uniformly.
Preferably four, step (5) total mix condition are as follows: by maltodextrin, ocean fish oligopeptide, fructose and fat It by load weighted amount, is added separately in first mixing obtained in above-mentioned steps (4), is not higher than 28 DEG C in temperature and humidity is little 20~40min, preferably 30min are mixed in 65% environment, until uniformly.
The third aspect, the present invention provide the purposes of above-mentioned low slag nutrient formulation product.
One is purposes of the product in bowel preparation.
The second is the product is preparing the purposes in bowel preparation product.
The bowel preparation is in Sigmoidoscope, small intestine mirror, ultrasound as a preferred technical solution, Bowel preparation before mirror, Capsule Endoscopy.
It is highly preferred that the bowel preparation is the bowel preparation before colonoscopy.
The third is the product is needing the purposes in the bowel preparation before the surgery of INTESTINAL CLEANSING.The surgery hand Art includes colorectal neoplasm operation, radical resection for colorectal cancer, pancolectomy, the operation of laparoscope lower gastrointestinal tract, head of pancreas duodenum Resection, small intestine wide excision, partial enterectomy, intestines stoma (fistula) Closure.
The fourth is purposes of the product in the postoperative nutritional support of intestinal surgery, the intestinal surgery operation include Colorectal neoplasm operation, radical resection for colorectal cancer, pancolectomy, the operation of laparoscope lower gastrointestinal tract, Pancreatoduodenectomy, Small intestine wide excision, partial enterectomy, intestines stoma (fistula) Closure.
Bowel preparation of the present invention is eaten using the low slag nutrient formulation product as early, middle and late breakfast, lunch and dinner, Every meal dosage is 120-180g.
Low slag nutrient formulation product of the invention has the advantages that
Compared with the mode of the Elental of the prior art and traditional liquid food dining INTESTINAL CLEANSING, using of the invention It is more preferable that low slag nutrient formulation product carries out bowel preparation effect.Including following aspect:
1, any dietary fiber is not added, and content of cellulose is very low, while easily being fully absorbed by small intestine, largely reduces intestines Swill in road improves cleaning intestinal tract degree, improves microscopy recall rate and detection quantity, reduces microscopy time and difficulty, avoids Repeat microscopy；The incidence of intestinal surgery patient with operation infection is reduced simultaneously.
2, food-borne aerogenic composition is free of, enteron aisle is avoided to produce inflatable gas, reduces enteron aisle bubble generation rate, improves microscopy quality And success rate.
3, nutrition-allocated proportion science comprehensively, supplements enough nutrition for microscopy and intestinal surgery patient, effectively reduces bowel lavage mistake The generation of the adverse reactions such as dizziness, palpitaition, syncope in journey；The immunity of operation patients is improved, hypoimmunity is effectively solved and makes At post-operative recovery slowly, easy infection the problems such as.
4, pure natural, high-quality is selected, the ocean fish oligopeptide that easily absorbs and rice protein powder are as albumen source, substitution The casein that hardly possible absorbs, being collocated with for the double protein absorb nutrition conducive to patient.
5, low slag nutrient formulation product of the invention is free of lactose, and some patients is avoided to cause abdomen due to lactose intolerance It rushes down, is easy to be received by patient.
Embodiment
The present invention is further described in detail combined with specific embodiments below, and the embodiment provided is only for example The present invention is illustrated to property, the range being not intended to be limiting of the invention.Without departing from the spirit and substance of the case in the present invention, right Any modifications or substitutions, all belong to the scope of the present invention made by the present invention.
Embodiment 1: low slag nutrient formulation product 1
In the every 1000g product of the present embodiment, as vitamin, contain: L-AA sodium 1.6g, niacinamide 0.23g, leaf Sour 0.0021g, dl- α-D-α-tocopherol acetate 0.5g, D-VB5 calcium 0.1g, riboflavin 0.17g, puridoxine hydrochloride 0.34g, hydrochloric acid sulphur Amine element 0.02g, retinol acetate 0.06g, Vitamin D3 0.03g, phytondione 0.0007g, cyanocobalamin 0.00007g, D- are raw Object element 0.00015g.
In the every 1000g product of the present embodiment, as minerals, contain: ferrous sulfate 0.2g, zinc sulfate 0.2g, magnesium sulfate 15g and calcium carbonate 2.2g, these minerals use 20g maltodextrin to be uniformly mixed as embedding medium.
The raw material dosage of every 1000g product: ocean fish oligopeptide 221g, rice protein 33g, maltodextrin 100g (including Maltodextrin as embedding medium), fat 320g, sodium carboxymethylcellulose 16g, vitamin and mineral amount as described above, Surplus is fructose, wherein fat is made of vegetable fat and medium chain triglyceride 5:3 in mass ratio, the vegetable fat is by corn Oil, sunflower oil, soybean oil, rapeseed oil and coconut oil 31:21.5:20:19:8.5 in mass ratio composition.
Preparation: (1) it pre-processes: each raw material and the ultraviolet light irradiation of food additives is carried out disinfection processing for 2 hours；(2) It weighs: each raw material and food additives is weighed according to dosage；(3) it pulverizes and sieves: former food additives is crossed 100 respectively Sieve more than mesh；(4) it just mixes: by various vitamins, various minerals, rice protein and sodium carboxymethylcellulose according to weighing Amount in 20 DEG C of environment (control humidity be not more than 65%) carry out just mixed 20min, until uniformly；(5) total mix: malt is pasted Essence, ocean fish oligopeptide, fructose, fat are added separately in first mixing obtained in above-mentioned steps (4) according to load weighted amount, 30min is mixed in the environment of 20 DEG C (control humidity is not more than 65%), until uniformly；(6) quantitative filling, packaging: by step (5) amount of the total mixture obtained as needed is filled and packs, and prepares low slag nutrient formulation product 1.
Embodiment 2: low slag nutrient formulation product 2
In the every 1000g product of the present embodiment, as vitamin, contain: L-AA sodium 1.5g, niacinamide 0.18g, leaf Sour 0.0017g, dl- α-D-α-tocopherol acetate 0.4g, D-VB5 calcium 0.07g, riboflavin 0.1g, puridoxine hydrochloride 0.2g, hydrochloric acid sulphur Amine element 0.016g, retinol acetate 0.04g, Vitamin D3 0.03g, phytondione 0.0005g, cyanocobalamin 0.00006g, D- Biotin 0.00012g.
In the every 1000g product of the present embodiment, as minerals, contain: ferrous sulfate 0.15g, zinc sulfate 0.15g, sulfuric acid Magnesium 13g and calcium carbonate 1.9g, these minerals use 20g maltodextrin to be uniformly mixed as embedding medium.
Raw material dosage: ocean fish oligopeptide 210g, rice protein 33g, fructose 250g, fat 355g, carboxymethyl cellulose Sodium 16g, vitamin and mineral amount as described above, surplus is maltodextrin, the fatty powder contains plant with mass ratio 5:3 Grease and medium chain triglyceride, the vegetable fat press quality by corn oil, sunflower oil, soybean oil, rapeseed oil and coconut oil It is formed than 31:21.5:20:19:8.5.
The preparation method is the same as that of Example 1, prepares low slag nutrient formulation product 2.
Embodiment 3: subjective appreciation experiment
(1) subjective appreciation volunteer: colonoscopy is tested 30 people of personnel, 20 people of enteron aisle postoperative patient.Personnel are tested for colonoscopy, 1 day breakfast, lunch and dinner takes formulation of the invention before colonoscopy, 1-2 bags each, with 200ml warm boiled water.For enteron aisle postoperative patient Person, postoperative 3 days breakfast, lunch and dinner are taken, 1-2 bags each, with 200ml warm boiled water.
(2) the sensory experience evaluation result such as table 2 of colonoscopy subject personnel.
Table 2: microscopy subjective appreciation
Mouthfeel Number Smell Number Adverse events Number
It is delicious 22 Smell is fine 24 Abdominal distension 0
Taste is preferable 8 Smell is preferable 5 Nausea and vomiting 0
Taste is general 0 It can be resistant to 1 Dizzy palpitaition 0
Taste is poor 0 It is not resistant to 0
(3) sense organ of postoperative patient and nutritional support experience such as table 3.
Table 3: nutrition in postoperative supports experience
Mouthfeel Number Smell Number Adverse events Number
It is delicious 18 Smell is fine 19 Bleeding 0
Taste is preferable 2 Smell is preferable 1 Perforation 0
Taste is general 0 It can be resistant to 0 Infection 0
Taste is poor 0 It is not resistant to 0
The above results show that inventive article good mouthfeel, taking dose are suitble to, and sleep is normal, has no adverse reaction.
Embodiment 4: low slag nutrient formulation product intestine cleaning effect evaluation
By comparing colonoscopy patient using low slag nutrient formulation product auxiliary INTESTINAL CLEANSING and traditional INTESTINAL CLEANSING The difference of method assesses the effect of low slag nutrient formulation product of the invention in Sigmoidoscope INTESTINAL CLEANSING.
(1) research object
The quasi- patient for carrying out colonoscopy.Selected age 18-65 one full year of life, weight < 60kg, the next morning receive intestines Spectroscopy.It excludes following patient: thering are severe psychiatric diseases to be difficult to cooperate the patient not good enough with communication capability；Merge hyperglycemia to suffer from Person, serious constipation patient, Diagnosing Gastrointestinal Bleeding；There are colonic operation history patient, obstruction of colon, pregnant woman, nursing period and plan The female patient of gestation；It is known or suspect heart failure, apoplexy, chronic group of match tuberculosis, renal failure etc. other be not resistant to intestines Spectroscopy person.
(2) test method
Using prediction randomized controlled trial design, is simulated using computer software and generate random number, screening is qualified 60 subjects are randomly divided into test group and control group according to the ratio of 1:1, and every group 30.
Control group patient gives conventional Sigmoidoscope preoperative INTESTINAL CLEANSING, specific steps are as follows: extremely takes within 1 day before colonoscopy Before cathartic, soft noodles or congee are eaten as breakfast, lunch and dinner, no longer eats other foods, it can free water.
The INTESTINAL CLEANSING step of test group patient are as follows: before colonoscopy 1 day to before taking cathartic, take embodiment 2 Low slag nutrient formulation product as breakfast, lunch and dinner, every meal 120-180g is taken, no after mixing evenly in 200ml or so warm water Other foods are eaten again, it can free water.
The patient of control group and test group starts to take cathartic in inspection evening before yesterday 20:00 point, checks morning on same day 5:00 Cathartic is taken again, and water is prohibited after 6:30.
(3) observation index
Index 1: cleaning intestinal tract degree.
Cleannes standards of grading use Boston scale score method.Colon is divided into right side colon, cross by Boston scale It scores after 3 sections of colon, left side colon, suction and perfusion.Every section of colon scoring is 0~3 point, and 0~9 point of total score；Every section of colon >=2 points of prompt INTESTINAL CLEANSINGs that score are abundant；Total score < 6 divides or any one section of colon score < 2 divide for INTESTINAL CLEANSING it is insufficient, tool Body standards of grading are as follows:
Boston scale score method
Score Right side colon, transverse colon, the scoring of left side colon segmentation
0 point There are a large amount of solid residues, mucous membrane is invisible
1 point There are solid or liquid residual, partial mucosa visible
2 points There are brown liquid, removable semisolid residual, mucous membrane is all visible
3 points Cleaning, mucous membrane are all visible
Index 2: adenoma and polyp recall rate, detection quantity.
Index 3: flatulence impression.
(4) test result
From the above results:
In test group, cleaning intestinal tract degree qualification is 20, accounts for 66.7%；In control group, cleaning intestinal tract degree qualification is 15, account for 50%.Therefore, control is substantially better than using the cleaning intestinal tract degree of the patient of the low full nutrient formulation product of slag of the present invention Group.
In test group, the detection number of cases of polyp is 23, accounts for 76.7%；It is 18 that adenoma, which detects number of cases, accounts for 60%.Control In group, it is 18 that polyp, which detects number of cases, accounts for 60%；It is 11 that adenoma, which detects number of cases, accounts for 36.7%.Therefore, using of the invention For the patient of the low full nutrient formulation product of slag when carrying out colonoscopy, polyp and adenoma recall rate are higher than control group.
In test group, there is not flatulence phenomenon, and there are 9 to have flatulence in control group.Therefore, test group flatulence is sent out Raw rate is significantly lower than control group.
By above-mentioned test result it is found that low slag nutrient formulation product of the invention and conventional Sigmoidoscope INTESTINAL CLEANSING method phase Than that can significantly improve the cleannes of enteron aisle, reduce flatulence in abdomen, to improve the recall rate of adenoma and polyp, promote postoperative Restore, reduce check cost, improves microscopy safety.

Claims (10)

1. a kind of low slag nutrient formulation product, which is characterized in that contain following component: protein, carbohydrate, fat, dimension Raw element and minerals.
2. low slag nutrient formulation product as described in claim 1, which is characterized in that the protein is selected from ocean fish oligopeptide And/or rice protein；The carbohydrate is selected from maltodextrin and/or fructose；The fat is selected from corn oil, sunflower seeds It is at least two kinds of in oil, soybean oil, rapeseed oil, coconut oil and medium chain triglyceride；The vitamin is selected from L-AA Sodium, niacinamide, folic acid, dl- α-D-α-tocopherol acetate, D-VB5 calcium, riboflavin, puridoxine hydrochloride, thiamine hydrochloride, acetic acid view are yellow It is at least two kinds of in ester, Vitamin D3, phytondione, cyanocobalamin and D-Biotin；The minerals be selected from ferrous sulfate, It is zinc sulfate, magnesium sulfate, at least two kinds of in calcium carbonate；Food additives are optionally added in the nutrient formulation product；Preferably, In every 100g product, dietary fiber content is 1.2g or less.
3. low slag nutrient formulation product as claimed in claim 1 or 2, which is characterized in that in the low slag nutrient formulation product Containing ocean fish oligopeptide, rice protein, maltodextrin, fructose, corn oil, sunflower oil, soybean oil, rapeseed oil, coconut oil, Medium chain triglyceride, L-AA sodium, niacinamide, folic acid, dl- α-D-α-tocopherol acetate, D-VB5 calcium, riboflavin, hydrochloric acid pyrrole It trembles alcohol, thiamine hydrochloride, retinol acetate, Vitamin D3, phytondione, cyanocobalamin, D-Biotin, ferrous sulfate, sulfuric acid Zinc, magnesium sulfate, calcium carbonate and the food additives optionally added such as sodium carboxymethylcellulose.
4. the low slag nutrient formulation product as described in any one of claim 1-3, which is characterized in that the low slag battalion of every 1000g It supports and contains ocean fish oligopeptide 140-240g, rice protein 22-37g, maltodextrin 80-120g, fructose 170- in formulation 290g, fat 230-400g, L-AA sodium 0.6-1.8g, niacinamide 0.1-0.25g, folic acid 0.001-0.003g, dl- α- D-α-tocopherol acetate 0.23-0.55g, D-VB5 calcium 0.05-0.12g, riboflavin 0.09-0.22g, puridoxine hydrochloride 0.15- 0.34g, thiamine hydrochloride 0.01-0.028g, retinol acetate 0.03-0.07g, Vitamin D3 0.015-0.034g, plant first Naphthoquinones 0.0004-0.0009g, cyanocobalamin 0.00004-0.00009g, D-Biotin 0.00007-0.00018g, ferrous sulfate 0.08-0.25g, zinc sulfate 0.08-0.22g, magnesium sulfate 7-17g, calcium carbonate 1.2-2.9g and the food additives optionally added Sodium carboxymethylcellulose 10-18g；It is preferred that the fat contains vegetable fat and medium chain triglyceride with the mass ratio of 4-6:2-4, The vegetable fat is by corn oil, sunflower oil, soybean oil, rapeseed oil and coconut oil 28-32:18-22:18-22 in mass ratio: 18-22:6-9 composition.
5. the low slag nutrient formulation product as described in any one of claim 1-4, which is characterized in that the low slag battalion of every 1000g It supports and contains ocean fish oligopeptide 170-210g, rice protein 26-33g, maltodextrin 95-120g, fructose 225- in formulation 250g, fat 320-370g, L-AA sodium 1.1-1.7g, niacinamide 0.13-0.23g, folic acid 0.0013-0.0023g, Dl- α-D-α-tocopherol acetate 0.3-0.5g, D-VB5 calcium 0.07-0.1g, riboflavin 0.1-0.17g, puridoxine hydrochloride 0.2- 0.25g, thiamine hydrochloride 0.012-0.02g, retinol acetate 0.03-0.06g, Vitamin D3 0.02-0.03g, plant first naphthalene Quinone 0.0004-0.0007g, cyanocobalamin 0.00004-0.00007g, D-Biotin 0.00008-0.00016g, ferrous sulfate 0.1- 0.2g, zinc sulfate 0.1-0.2g, magnesium sulfate 11-15g, calcium carbonate 1.8-2.2g and the food additives carboxymethyl optionally added are fine Tie up plain sodium 13-16g.
6. the low slag nutrient formulation product as described in any one of claim 1-5, which is characterized in that the low slag battalion of every 1000g It supports and contains ocean fish oligopeptide 205-210g, rice protein 30-33g, maltodextrin 100-118g, fructose 235- in formulation 250g, fat 340-360g, L-AA sodium 1.2-1.6g, niacinamide 0.18-0.2g, folic acid 0.0017-0.002g, dl- α-D-α-tocopherol acetate 0.35-0.45g, D-VB5 calcium 0.07-0.08g, riboflavin 0.1-0.14g, puridoxine hydrochloride 0.2- 0.25g, thiamine hydrochloride 0.012-0.02g, retinol acetate 0.04-0.05g, Vitamin D3 0.02-0.03g, plant first naphthalene Quinone 0.0005-0.0006g, cyanocobalamin 0.00005-0.00006g, D-Biotin 0.0001-0.00012g, ferrous sulfate 0.15- 0.2g, zinc sulfate 0.15-0.18g, magnesium sulfate 13-14g, calcium carbonate 1.8-2.0g and the food additives carboxymethyl optionally added Sodium cellulosate 13-16g.
7. the preparation method of low slag nutrient formulation product described in any one of claim 1-6 comprising following steps: (1) it pre-processes, (2) weigh, (3) pulverize and sieve, (4) just mix (5) total mix.
8. the low full nutrient formulation product of slag is in preparing bowel preparation product described in any one of claim 1-6 Purposes.
9. purposes as claimed in claim 8, the bowel preparation is the intestines before intestinal surgery is preoperative or enteroscopy Road cleaning prepares.
10. the low full nutrient formulation product of slag is in the postoperative nutrition branch of intestinal surgery described in any one of claim 1-6 Purposes in holding.
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CN110623257A (en) * 2019-09-20 2019-12-31 麦孚营养科技（北京）有限公司 Application of composition for intestinal tract in preparation of diagnosis and treatment product for intestinal tract disease
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