CN102106538A - Healthcare product prepared from rhodiola root, spirulina and notoginseng - Google Patents
Healthcare product prepared from rhodiola root, spirulina and notoginseng Download PDFInfo
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Abstract
The invention relates to a healthcare product prepared from rhodiola root, spirulina and notoginseng, in particular to healthcare food containing extracts of rhodiola root, spirulina, notoginseng, cordyceps sinensis powder, ginseng and the like, belonging to the field of healthcare products. The invention provides multifunctional healthcare food which takes rhodiola root, notoginseng, spirulina, cordyceps sinensis powder, ginseng and the like as main raw materials. The healthcare product provided by the invention comprises the following raw materials in parts by weight: 1-9 parts of rhodiola root extract, 1-9 parts of spirulina, 1-9 parts of notoginseng extract, 1-9 parts of cordyceps sinensis powder, 1-9 parts of ginseng extract and a proper amount of subsidiary materials. The healthcare food provided by the invention has obvious efficacies of fatigue resistance and immune regulation.
Description
Technical field
The invention belongs to field of health care products, relate in particular to a kind of health food that contains extracts such as rhodiola root, spirulina, pseudo-ginseng, cordyceps, genseng.
Background technology
Health products are functional food that a kind of people of help transforms to health status from sub-health state, it should have one or more functions of regulating function of human body, as anti-fatigue effect, immunoloregulation function, deferring senility, raising memory function, supplemental treatment function etc.
" rhodiola root " is acknowledged as " totipotency medicine ".Contain 35 kinds of trace elements in the rhodiola root, 18 seed amino acids, vitamin A, D, E and activity of fighting against senium superoxides, its nutritional labeling is complete and compatibility is reasonable.Aspect pharmacology, proved that now rhodiola root has stronger inhibition and regulating action to central nervous system, antifatigue, anti-anoxic, anti-ageing, radioresistance, antitumor and anti-inflammatory, detoxifcation, the effect of raising autoimmunity are arranged preferably, be the potential activator of human body self cell, nerve system of human body, blood circulation system, metabolic system, internal system etc. are had the good whole opsonic action.(1999 the 10th the 4th phases of volume of precious traditional Chinese medical science traditional Chinese medicines during the old Qi rhodiola root of list of references: Wang Liang trip Chinese ilex pharmacological research progress)
It is " optimum medicines of human 21 century " that " spirulina " quilt " World Health Organization " is defined as, and is to be described as " two big important discoveries of twentieth century " jointly with atomic energy, and its effect is bigger than atomic energy.Spirulina contains water-soluble phycocyanin, very easily absorbed and utilize by human consumption, 18 seed amino acids that also contain needed by human body, the proposed standard of its amino acid composition and FAO (Food and Agriculture Organization of the United Nation) (FAO) is very approaching, also contain various trace elements, spirulina polysaccharides (PSP) etc. such as carrotene, vitamin C, vitamin E, multiple B family vitamin, iron calcium magnesium selenium zinc potassium sodium copper iodine, also contain needed by human body biology enzymes such as SOD, so spirulina is the nutraceutical that nutrition known today is the most comprehensive, the most balanced, the most easily be absorbed by the body.Aspect pharmacology, proved that now spirulina can improve immunity of organisms, antitumor, auxiliary laser and control multiple functions such as cancer, anti-anaemia, reducing blood lipid, hypoglycemic, anti-gastric-ulcer, radioresistance, anti-oxidant, antifatigue, anti-ageing, antiviral, antiallergy.(reference: the pharmacology of Sun Chun swallow spirulina and newspaper (the ACAD J GCP) 1998,14 (1) of clinical research new development Guangdong Pharmaceutical University: 60-63)
Pseudo-ginseng has another name called pseudo-ginseng, and the famous pharmacy man Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is called " invaluable ".Pseudo-ginseng is a jewel in the Chinese medicine, puts down in writing in Qing Dynasty's pharmacy works supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying the first, pseudo-ginseng enrich blood the first, the flavor with and merit also waits, so the title Panax pseudoginseng, be the most precious person in the Chinese medicine." pseudo-ginseng contains saponin, is mainly sanchinoside E1, Rg1, Rg2 and a small amount of panaxoside Ra, Rb2, Rb and Re.In addition, still contain glycosides displayed, starch, protein, grease etc.Aspect pharmacology, now proved pseudo-ginseng antifatigue, anti-anoxic, blood circulation promoting and enriching, thrombus dissolving, reduction MCO, improve myocardial ischemia, anti-arrhythmia, reducing blood lipid, hypotensive, anti-shock, improve brain blood circulation, calmness, ease pain, increase intelligence, hypoglycemic, delay senility, antibiotic, antitumor etc.
Chinese caterpillar fungus is described as " magical celestial grass ", classifies China's three big tonics as with genseng, pilose antler, is the rare traditional Chinese medicine of China.Be unique balance simultaneously, regulate the Chinese medicine of negative and positive.The main component of Chinese caterpillar fungus has cordycepic acid, cordycepin, amino acid, sterol, sweet mellow wine, alkaloid, vitamin B1, B2, polysaccharide and mineral matter etc.Aspect pharmacology, now proved kidney tonifying moistening lung, nourishing generate fluid, Yin Yang balancing, delayed senility, the immunity of cancer-resisting, anaemia weakness, hepatitis B, raising human body has been worked the effect of consolidating.Have and regulate immune system, cardiac function, liver function, respiratory system function, renal function, hematopoiesis function, central nervous system function and regulate blood fat, sexual function, antifatigue, main effect such as antiviral, antitumor.
Genseng has the good reputation of " kings of hundred grass " since ancient times, more is described as the superfine product of " enriching yin is mended and given birth to, and strengthens the body resistance to consolidate the constitution " by oriental medicine circle.Genseng contains multiple saponin and polysaccharide composition, also contains organic acid and ester class, vitamin, 20 various trace elements etc.Aspect pharmacology, now proved antifatigue, anti-anoxic, blood circulation promoting and enriching, thrombus dissolving, reduction MCO, improve myocardial ischemia, anti-arrhythmia, reducing blood lipid, hypotensive, anti-shock, improve brain blood circulation, calmness, ease pain, increase intelligence, hypoglycemic, delay senility, antibiotic, antitumor etc.
Be the effect and the pharmacological function of single diet above, also have on the market one to two or one to three health food that combinations of foods is mixed with, but above-mentioned five kinds of formulated multi-function health care foods of combinations of foods be yet there are no report.
Investigation shows, there is 87% people that slight anoxia phenomenon is all arranged in the urban population, this mainly is because a kind of physiological phenomenon that environmental pollution, pressure are big, nervous, the electromagnetic radiation of electronic product etc. is caused, valetudinarian, the elderly, brain worker are the main crowds of easy anoxic, symptom such as anoxic can cause that human body headache and dizzy occurs, uncomfortable in chestly breathe hard, is losing one's memory, lassitude, health are tired.Both are interactional for anoxic and fatigue, red scape seven, pseudo-ginseng, Chinese caterpillar fungus all live in the thin highlands of oxygen, itself just has very strong anti-anaerobic environment adaptive capacity, spirulina contains multiple abundant nutrient in addition, can strengthen the resistance of human body, make people adapt to the situation of anoxic.
Denomination of invention
The purpose of this invention is to provide a kind of multi-function health care food based on rhodiola root, pseudo-ginseng, spirulina, Chinese caterpillar fungus powder and genseng etc.
For achieving the above object, the present invention adopts following technical scheme, and the present invention is made up of the raw material of following weight portion: 1～9 part of gadol extract, 1～9 part of spirulina, 1～9 part of Notogineng Extract, cordyceps: 1～9 part, 1～9 part of ginseng extract, right amount of auxiliary materials.
Described spirulina is former powder, and cordyceps is the artificial bacterium powder of cultivating.
Described auxiliary material is carboxylic first Dian Fen Na, dried starch, hydroxypropyl methyl cellulose, the fine little element of crystallite, Icing Sugar, dextrin.
The content of the rhodioloside in the extract of described rhodiola root 〉=0.2%.
The content of the arasaponin in the extract of described pseudo-ginseng 〉=5%.
The content of the general ginsenoside in the extract of described genseng 〉=5%.
The present invention makes tablet, granule, capsule etc. by said components according to conventional preparation methods such as traditional Chinese medicine extraction, refining, mixing, granulations.
Beneficial effect:
With " rhodiola root, spirulina, pseudo-ginseng, cordyceps, genseng " refining " seven on red spiral shell " health food that forms, can get through the blood vessels of body, the conveying capacity of replenishing nutrient, raising nutrient, make the anti-anoxic of cell, anti-oxidant, the weak part of recovery body simultaneously, so have very significant antifatigue, immunological regulation effect; After edible " seven on red spiral shell ", can recover the function of body rapidly, delaying cell aging improves resistance against diseases.
Health products of the present invention, becoming human body to recommend amount is 3.2g, is converted to 53.3mg/kg BW by the 60kg body weight.
Below further specify effect of the present invention with experiment situation or testing result:
1, according to Ministry of Public Health's " health food check and assessment technique standard " (version in 2003) alleviating physical fatigue function zoopery method:
Select 192 of cleaning level (II level) the healthy adult Kunming mouses of Guangxi Medical University medical experiment animal center breeding for use, body weight is 18-22g, and is male.The human body of sample is recommended consumption according to the present invention, if 267,533, the experimental group of 3 dosage of 1066mg/kg BW (be equivalent to human body respectively and recommend 5,10,20 times of consumption), establish a negative control group (distilled water) simultaneously, amount to 4 groups, every group of 12 animals at random.Adopt per os mode administration by gavage, every day, the capacity with 0.2ml/10gBW was tried thing, and negative control group gives equivalent distilled water.Once a day, continuous 30 days.
(1) swimming with a load attached to the body experiment: after last is tried thing 30min to mouse, place the swimming case to swim, the about 30cm of the depth of water, 25 ℃ ± 0.5 ℃ of water temperature, the load sheet lead of 5% body weight of mouse root of the tail portion.The record mouse is from the extremely dead time of swimming beginning, as mouse swimming with a load attached to the body time (s).
If the experimental group swimming time obviously is longer than the negative control group swimming time, and difference has conspicuousness (P＜0.05), and this is tried decidable thing the effect that prolongs the mouse swimming with a load attached to the body time is arranged.
(2) serum urea is measured: after last is tried thing 30min to mouse, be that not swimming with a load attached to the body 90 is quick in 30 ℃ the water in temperature, pull out eyeball blood sampling 0.5ml behind the motion back rest 60min immediately, centrifuging and taking serum adds measures serum urea value (enzyme process kit).
If experimental group serum urea content is starkly lower than the negative control thing, and difference has conspicuousness P＜0.05), this is tried the effect that thing has the tired mouse urea of minimizing to produce decidable.
(3) hepatic glycogen is measured: after last is tried thing 30min to mouse, put to death immediately, get liver and blot with filter paper after the physiological saline rinsing, accurately take by weighing liver 100mg, add TCA, homogenate, centrifugal is got supernatant and is measured hepatic glycogen content (anthrone method).
If the experimental group hepatic glycogen content is starkly lower than the negative control thing, and difference has conspicuousness (P＜0.05), and this is tried decidable thing the effect that promotes Mouse Liver glycogen deposit is arranged.
(4) blood lactic acid is measured: after last is tried thing 30min to mouse, respectively before swimming, the rest 20min 20 μ L that take a blood sample carry out lactic acid mensuration behind swimming (motion) the back 0min, swimming (motion).Blood lactic acid TG-AUC calculates with following formula:
Blood lactic acid TG-AUC=1/2 * (the blood lactic acid value of quiet blood lactic acid value+motion back 0min) * 10+1/2 * (the blood lactic acid value of the blood lactic acid value of motion back 0min+motion back 20min) * 20
If experimental group blood lactic acid changing value is starkly lower than the negative control thing, and difference has conspicuousness (P＜0.05), and this is tried decidable thing the effect that reduces blood lactic acid TG-AUC behind the mouse movement is arranged.
Experimental data employing SPSS software is done between variance analysis and group and is compared.
The result:
Table 1 respectively organize mouse the swimming with a load attached to the body time (± SD)
By table 1 as seen, heavy burden (5%) swimming time of each dosage group mouse of sample of the present invention is all than the prolongation of negative control group, and the difference of each dosage group and recessive control group all has conspicuousness (P＜0.01 or P＜0.05), shows that the present invention can prolong the swimming with a load attached to the body time of mouse.
Table 2 respectively organize serum urea measurement result behind the mouse movement (± SD)
By table 2 as seen, the serum urea nitrogen content of each dosage group mouse of sample of the present invention all is lower than negative control group, the difference of wherein high, middle dosage group and negative control group has conspicuousness (P＜0.05), shows that the present invention can reduce or suppress the serum urea nitrogen generation of tired mouse.
Table 3 respectively organize Mouse Liver glycogen content measurement result (± SD)
By table 3 as seen, the hepatic glycogen content of each dosage group mouse of sample of the present invention all is higher than negative control group, and the difference of each dosage group and negative control group all has utmost point conspicuousness (P＜0.01), shows that this sample has the effect of the hepatic glycogen deposit that promotes mouse.
Table 4 respectively organize blood lactic acid (mmol/L) TG-AUC behind the mouse movement (± SD)
By table 4 as seen, 3 time point blood lactic acid TG-AUCs of each dosage group of sample of the present invention are all less than negative control group, the difference of height wherein, middle dosage group and negative control group has conspicuousness respectively (P＜0.01 and P＜0.05), shows that the present invention has the effect that reduces blood lactic acid TG-AUC behind the mouse movement.
Brief summary: per os gives the sample of the present invention 30 days of mouse 267,533,1066mg/kg BW (being equivalent to 5,10,20 times of human body recommended amounts respectively) dosage respectively, can prolong the swimming with a load attached to the body time of mouse, the serum urea that reduces tired mouse produce, increase the hepatic glycogen of mouse storage level, reduce blood lactic acid TG-AUC behind the mouse movement.This shows that the present invention has the effect of alleviating physical fatigue function.
2, according to improving the anoxia tolerant function test in Ministry of Public Health's " health food check and assessment technique standard " (version in 2003):
Select 144 of cleaning level (III level) the healthy adult Kunming mouses of Guangxi Medical University medical experiment animal center breeding for use, body weight is 18-22g, and is male.According to human body recommended amounts of the present invention, if 266,533, the test group of 3 dosage of 1066mg/kg BW (be equivalent to human body respectively and recommend 5,10,20 times of consumption), establish a negative control group (distilled water) simultaneously, amount to 4 groups, every group of 12 animals at random, adopt per os mode administration by gavage, every day, the capacity with 0.2ml/10gBW was tried thing, and negative control group gives equivalent distilled water.Once a day, continuous 30 days.
(1) the anti-anoxic experiment of normal pressure: 60min behind the last filling stomach, each is organized the 250mL port grinding bottle (every bottle) that mouse is put into the 5g soda lime respectively, with bottle stopper and vaseline sealing bottleneck, the record mouse is because of the time of anoxic death.Test data is carried out statistical disposition with variance analysis.Given the test agent group and negative control group compare, prolonged survival period, and have statistical significance, then judge this result of the test positive.
(2) natrium nitrosum poisoning survival test:
60min behind the last filling stomach, each organizes mouse by 240mg/kgBW dosage lumbar injection natrium nitrosum (injection volume is 0.1mL/10gBW), injects the timing immediately that finishes, and the record mouse poisons the time of surviving in the back.Test data is carried out statistical disposition with variance analysis.Given the test agent and recessive control group compare, prolonged survival period, and have statistical significance, then judge this experimental result positive.
(3) acute cerebral ischemia hypoxia test: 60min behind the last filling stomach, each treated animal is by only break end timing immediately, the time that the record mouse breaks end and breathes and stop to dehiscing certainly fast from neck.Test data is carried out statistical disposition with variance analysis.Be put to the test product and recessive control group relatively, prolonged survival period, and have statistical significance, then judge this experimental result positive.
The experiment of the anti-anoxic of the above-mentioned normal pressure that carries out, natrium nitrosum are poisoned, and wantonly two results are positive in survival experiment, the experiment of acute cerebral ischemia anoxic, and this is tried decidable thing and have the anti-anoxia tolerant function effect of raising.
The result:
The anti-anoxic experimental result of table 5 mouse normal pressure (± S)
Table 6 mouse natrium nitrosum poisoning survival test result (± S)
Table 7 chmice acute cerebral ischemia anoxic experimental result (± S)
By table 5, table 6, table 7 as seen, respectively with 266,533, the sample of the present invention of 1066mg/kg BW dosage gives mouse stomach 30 days continuously, the result can prolong mouse because of time of hypoxia death, prolong time-to-live and mouse the dehiscing breathe time acute cerebral ischemia anoxic (broken end) after of mouse after natrium nitrosum is poisoned.This shows that the present invention has the effect of the anoxia tolerant function of raising.
3, according to toxicity test in Ministry of Public Health's " health food check and assessment technique standard " (version in 2003):
Selecting the healthy adult Kunming mouse and the Wistar kind rat of Guangxi Medical University's medical experiment animal center breeding for use is animal used as test, and salmonella typhimurium histidine defect type TA97a, TA98, TA100 and four kinds of bacterial strains of TA102 of selecting for use Beijing Disease Prevention and Control Centre's Institute for Toxicology to provide are test strain.
(1) acute toxicity testing: adopt maximum tolerated dose (MTD) test method(s), dosage is made as 15000mg/kg BW.Select 20 of Kunming mouses, body weight is 18-22g, each 10 of male and female.Animal fasting 16h before the test does not limit drinking-water, because of sample adds behind the water than thickness, so with distilled water sample is made into 250mg/mL concentration, irritates stomach 3 times (each interval 4h) to animal then, and irritate the stomach amount is 0.4mL/20gBW at every turn.The poisoning manifestations of observed and recorded animal is weighed weekly once, observes two time-of-weeks, dissects animal after the off-test and carries out gross examination of skeletal muscle.
Table 8 acute toxicity is observed situation
By table 8 as seen, tried thing after, growth of animal is good, not seeing has poisoning symptom, no animal dead is dissected the animal gross examination of skeletal muscle and be there is no unusually after the off-test.Judge in view of the above the present invention to the acute oral toxicity MTD of mouse greater than 15000mg/kg BW, press acute toxicity grading criteria, belong to nontoxic level.
(2) genetic toxicity test:
I, Salmonella reversion test: adopt flat board to mix method, establish 5 dosage groups of 5000,1000,200,40,8 μ g/ wares, establish untreated control, negative control group and positive controls simultaneously, amount to 8 groups.Untreated control is not except that adding sample of the present invention, and all the other conditions communicate with sample sets; Negative control group substitutes sample with sterile purified water, and all the other conditions are identical with sample sets; The positive mutagen of positive control is diamino-fluorene (2-AF), pubescence rhzomorph (DNR), fenaminosulf (Dexon) Sodium azide (NaN
3) and dihydro base anthraquinone (1,8-DAU). the rats'liver S that induces with Polychlorinated biphenyls
-9Mixed liquor is as the metabolism activation system.With distilled water with sample be made into 50,10,2,0.4 respectively, 5 concentration of 0.08mg/mL, handle the back conduct through autoclaving and tried solution.During test the insulation the top layer culture medium in add test strain enrichment liquid 0.1mL successively, (activation person adds 10%S again to be tried solution 0.1mL
-9Mixed liquor 0.5mL), pours into behind the mixing on the bottom culture medium flat plate, spread out rapidly.The various bacterial strains of each dosage group are all made 3 parallel wares.Cultivated 48 hours down at 37 ℃, count returning of every ware then and become clump count.Retest once.The result represents with the mean and the standard deviation of the meeting change bacterium colony of 3 parallel wares, with t check carrying out statistical analysis.If tried thing return to become clump count increase surpass negative control more than 2 times and have dose-response relationship, or a certain at least test point has repeatably and has the positive reaction of statistical significance, it is positive to think that then this is tried thing mutagenesis experiment.
Table 9.1Ames test experimental result (for the first time)
Annotate: above result (clump count) is the means standard deviation of 3 plates.
Table 9.2Ames test experimental result (for the first time)
Annotate: above result (clump count) is the means standard deviation of 3 plates.
By table 9.1, table 9.2 as seen, no matter whether add S
-9The metabolism activation system, the change clump count that returns of TA97a, TA98, TA100 and four kinds of test strains of TA102 there is no obvious increase, and the mutagenesis testing result is negative.
II, mouse marrow cell micro nuclear test: adopt 30h to be tried thing method (two minor tick 24h), per sample to the per os MTD (＞15000mg/kg BW) of mouse, establish 8000,4000 respectively, 3 dosage groups of 2000mg/kgBW.Other establishes a negative control and a positive control (endoxan 40mg/kg BW).Every group 10 mouse (25-30g), male and female half and half.With distilled water with sample be made into 400,200 respectively, 100mg/mL concentration, irritate stomach by 0.2mL/10g BW to animal.Negative control group is irritated to distilled water, and positive controls is irritated to endoxan solution.Give for the second time and tried behind the thing to put to death in 6 hours animal, get bone marrow of sternum and dilute smear with calf serum, after fixing and dyeing, examine under a microscope, every animal counting 1000 polychromatic erythrocytes (PCE), micronuclear rates is represented with the PCE permillage that contains micronucleus, being seen mature erythrocyte number (NCE) when counting is observed 200 polychromatic erythrocytes simultaneously calculates the PCE/NCE ratio.Adopt Poisson distribution mean comparison method to carry out statistical analysis, by the other distribution statistics of animality.Micronuclear rates as test group increases than negative control group, and tangible dose-response relationship and statistical significance are arranged, and can think positive findings.
Table 10 is respectively organized the mouse marrow cell micro nuclear test result
Annotate: * * represents to compare P＜0.01 with other each groups.
By table 10 as seen, the micronuclear rates of each dosage group of sample and negative control group relatively, difference there are no significant meaning (P＞0.05), and do not have dose-response relationship, show that this sample does not have obvious influence to the marrow polychromatic erythrocyte micronuclear rates of mouse, result of the test is negative.
III, mouse sperm deformity test: per sample to the per os MTD (＞15000mg/kg BW) of mouse, establish 8000,4000 respectively, 3 dosage groups of 2000mg/kg BW.Other establishes a negative control group and a positive controls (endoxan 40mg/kg BW), 10 every group male mices (26-35g).With distilled water with sample be made into 400,200 respectively, 100mg/mL concentration, irritate stomach by 0.2mL/10g BW to animal.Negative control group is irritated to distilled water, and positive controls is irritated to endoxan solution.Irritate stomach every day once, continuous 5 days.Last is given and to be tried behind the thing to put to death animal on the 30th day, gets the sperm smear of both sides epididymis, examines under a microscope after fixing and dyeing, and every zoometer counts up to 1000 of whole sperms, the calculating rate of teratosperm.Adopt Chi-square Test to carry out statistical analysis.Rate of teratosperm as test group increases than negative control group, and tangible dose-response relationship and statistical significance are arranged, and can think positive findings.
Table 11 respectively organize the mouse sperm deformity result of the test (± S)
Annotate: * * represents to compare P＜0.01 with other each groups.
By table 11 as seen, the rate of teratosperm of each dosage group of sample and recessive control group relatively, difference there are no significant meaning (P＞0.05), and do not have dose-response relationship shows that this sample does not have obvious influence to the mouse sperm deformity rate, result of the test is negative.
(3) 30 days feeding trials of rat: select 80 rats, each 40 of male and female, wherein male mouse body weight 70 ± 8.4g, female mouse body weight 74 ± 6.1g.Be divided into 4 groups at random by body weight, 20 every group, female male each 10.Per sample human body is recommended consumption, establishes 1333,2667,3 dosage groups of 5334mg/kg BW (be equivalent to human body respectively and recommend 25,50,100 times of consumption), and other establishes a negative control group.Employing is mixed the feed method to being tried thing, press 10% heavy conversion forage volume of animal body, sample is mixed basal feed mix thoroughly and be made into 1.33,2.67,5.33% content respectively, supply with corresponding dosage treated animal feeding every day then, negative control group is supplied with basal feed.Every single cage of rat is fed, and freely drinks water.Claim the weight of animals, twice feed surplus of title and the amount of scattering weekly one time.Observe every day animal general situation, to have or not poisoning manifestations and death, experimental period be 30 days, experiment finishes to put to death rat, carries out every detection.
Through test, this health food sample does not have obvious influence to the growing of rat, food utilization, and the every index of hematology and blood biochemical there is no unusually, and histopathologic examination does not find damaging pathological change yet.
The toxicity test conclusion:
Acute toxicity test: this sample greater than 15000mg/kg BW, belongs to nontoxic level to the acute oral toxicity MTD of mouse;
Genetic toxicity test: Salmonella reversion test, mouse marrow cell micro nuclear test, mouse sperm deformity result of the test are all negative;
30 days feeding trials of rat: respectively with 1333,2667, the sample of 3 dosage of 5334mg/kg BW (be equivalent to human body and recommend 25,50,100 times of consumptions) mixes feed and gives rat feeding 30 days continuously, as a result the body weight gain of rat, food utilization, routine blood test, blood biochemical, organ weights level dirty/all no abnormal change of body ratio, the liver,kidney,spleen of rat, stomach, duodenum, testis and ovary there is no Histopathology and change, and do not find that this sample is to the toxic effect of rat.
Through above-mentioned every evidence, the present invention is than control group energy significant prolongation mouse swimming time, significantly increase Mouse Liver glycogen content, mouse blood lactic acid TG-AUC obviously and obviously reduces the mice serum urea level, illustrate that the present invention has the good tired function of alleviating, also can improve anoxia endurance significantly, and safe and effective, have no side effect.
The specific embodiment:
Embodiment 1:
By weight: 4 parts of gadol extracts, 2 parts of spirulinas, 1 part of Notogineng Extract, 2 parts of cordyceps, 1 part of ginseng extract, right amount of auxiliary materials.Make tablet, granule, capsule according to conventional preparation method.
Embodiment 2:
By weight: 5 parts of gadol extracts, 1 part of spirulina, 1 part of Notogineng Extract, cordyceps: 2 parts, 1 part of ginseng extract, right amount of auxiliary materials.Make tablet, granule, capsule according to conventional preparation method.
Embodiment 3:
By weight: 6 parts of gadol extracts, 1 part of spirulina, 1 part of Notogineng Extract, cordyceps: 1 part, 1 part of ginseng extract, right amount of auxiliary materials.Make tablet, granule, capsule according to conventional preparation method.
The spirulina of above-mentioned employing is former powder, from the area, Cheng Hai lake of the northwestward, Yunnan Province;
Above-mentioned cordyceps is the artificial bacterium powder of cultivating.
Above-mentioned auxiliary material is carboxylic first Dian Fen Na, dried starch, hydroxypropyl methyl cellulose, the fine little element of crystallite, Icing Sugar, dextrin, and auxiliary material adopts the medicinal or edible adjuvant of health products trade.
The content of the rhodioloside in the extract of above-mentioned rhodiola root 〉=0.2%.
The content of the arasaponin in the extract of above-mentioned pseudo-ginseng 〉=5%.
The content of the general ginsenoside in the extract of above-mentioned genseng 〉=5%.
The present invention makes tablet, granule, capsule etc. by said components according to conventional preparation methods such as traditional Chinese medicine extraction, refining, mixing, granulations.
Claims (6)
1. red spiral shell seven health products, it is characterized in that: the raw material by following weight portion is formed: 1～9 part of gadol extract, 1～9 part of spirulina, 1～9 part of Notogineng Extract, cordyceps: 1～9 part, 1～9 part of ginseng extract, right amount of auxiliary materials.
2. red spiral shell seven health products according to claim 1, it is characterized in that: described spirulina is former powder, cordyceps is the artificial bacterium powder of cultivating.
3. red spiral shell seven health products according to claim 1 is characterized in that: described auxiliary material mainly is carboxylic first Dian Fen Na, dried starch, hydroxypropyl methyl cellulose, the fine little element of crystallite, Icing Sugar, dextrin.
4. red spiral shell seven health products according to claim 1 is characterized in that: the content of the rhodioside in the extract of described rhodiola root 〉=0.2%.
5. red spiral shell seven health products according to claim 1 is characterized in that: the content of the arasaponin in the extract of described pseudo-ginseng 〉=5%.
6. red spiral shell seven health products according to claim 1 is characterized in that: the content of the general ginsenoside in the extract of described genseng 〉=5%.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083384A (en) * | 2013-01-31 | 2013-05-08 | 李耀华 | Health-care fermentative cordyceps fungal powder composition and preparation technology thereof |
| CN105211870A (en) * | 2015-10-30 | 2016-01-06 | 永仁腾祥商贸有限公司 | A kind of nutritious health food and preparation method thereof |
| CN107087795A (en) * | 2017-05-26 | 2017-08-25 | 王忠良 | A kind of anti-fatigue anoxia-tolerance Halth-care composition |
| CN109846895A (en) * | 2019-02-20 | 2019-06-07 | 吉林大学 | Rhodioside is as the protectant new application of oral administration furans renal toxicity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083384A (en) * | 2013-01-31 | 2013-05-08 | 李耀华 | Health-care fermentative cordyceps fungal powder composition and preparation technology thereof |
| CN105211870A (en) * | 2015-10-30 | 2016-01-06 | 永仁腾祥商贸有限公司 | A kind of nutritious health food and preparation method thereof |
| CN107087795A (en) * | 2017-05-26 | 2017-08-25 | 王忠良 | A kind of anti-fatigue anoxia-tolerance Halth-care composition |
| CN109846895A (en) * | 2019-02-20 | 2019-06-07 | 吉林大学 | Rhodioside is as the protectant new application of oral administration furans renal toxicity |
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Application publication date: 20110629 |