CN101766659B - Preparation having function of improving memories and preparation method and application thereof - Google Patents
Preparation having function of improving memories and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a preparation having the function of improving memories and a preparation method and application thereof in improving memory. The preparation is mainly prepared by the following components: 2-90% of zinc-enriched yeast, 0.001-90% of selenium-enriched yeast, 0.1-10% of lecithin, 0.001-10% of vitamin B1, 0.001-10% of vitamin B2, 0.00002-0.05% of vitamin B12 and 0.1-30% of vitamin C by mass. The preparation can comprehensively supplement the cerebral nutrition in many aspects, thus having the effects of improving the memories, preventing loss of memories and preventing senile dementia. Besides, the preparation has novel, scientific and reasonable formula and has no side effects even if being taken for a long time.
Description
Technical field
The present invention relates to a kind of preparation of improving memory function and preparation method thereof that has, more particularly, relate to a kind of with yeast rich in zinc and yeast rich in selenium be primary raw material have preparation that improves memory function and preparation method thereof.
Background technology
Aging is reflected in the nervous system aspect, shows that neural excitation and process of inhibition weaken, the reduction of brain ability to work, hypomnesis and bradykinesia etc., further develops down senile dementia to occur.According to data, China is 2.5% in over-65s crowd person in middle and old age dementia prevalence, and the ratio of vascular dementia is 0.9%, and the dull-witted ratio of Combination is 0.9%, and concrete total number of persons is very huge.
There are four types of equilibrium systems in inside of human body: the spinal nerves system of 1, ordering about musculation; 2, preside over the autonomic nerve system of viscera function; 3, transmit the meridians system (or courier's system) of information; 4, regulate the endocrine system of vital movement.What in these four types of equilibrium systems, play adjusting, transmission, control action is neuroendocrine system, system of couriers and immune system.Trace element neurotoxic theory is thought; The Metabolic disorder of trace element in the body; Be element kind, content or proportional imbalance; Can cause corresponding enzyme, protein and hormone function unusual, and then cause regulatory mechanism obstacle, defense function obstacle, information conductive obstruction in the body, finally develop into senile dementia and body aging.So middle-aged and elderly people needs an amount of replenishing to the brain neuroblastoma beneficial trace elements, like zinc, selenium etc.
Zinc is that brain is grown trace elements necessary, and the deficiency of zinc can continue to damage the normal growth of neuronal cell.Zinc is essential element during neural generation and synapse take place, and zinc deficiency can be through changing the influence on development cognitive competence of attention, mobility, neuropsychic behavior and motion.Selenium has the effect of the free radical of removing antioxidative, and the antagonism toxic heavy metal prevents senile dementia to the destruction of cranial nerve.
Take in lecithin and can improve choline level and neural interior Ach level in the blood rapidly, promptly transmit the neurotransmitter of information in the brain.Vitamin and brain central nervous system's metabolism and function are closely related, lack some vitamin and can cause nervous system dysfunction.Research shows, old people's memory test integration and vitamin B2, the vitamin C concentration significant correlation in blood.Vitamin C and the low experimenter of vitamin B12 concentration remember integration and significantly are lower than vitamin C and the high experimenter of vitamin B12 concentration in the blood.Vitamin B1 and carbohydrate metabolism are in close relations, and the main energy sources of cerebral tissue is from the oxidation of glucose, and this possibly be the reason that causes nervous system dysfunction owing to its shortage easily.The shortage of vitamin B 12 can cause neurological disorders, memory loss and moral damage, even causes hematological change.The serum vitamin B12 of patients of senile dementia is obviously low.
To improve the product of memory class be main with Chinese medicine ingredients, lecithin, fish oil to middle-aged and elderly people in the market, is not the product of primary raw material with yeast rich in zinc, yeast rich in selenium also.The invention provides this primary raw material with the product that improves memory, and the composition of each composition.
Existed at present and added one, two kind of same materials but other primary raw material different techniques, in these technology, by employing different dosage forms, prescription form and be not quite similar.
That one Chinese patent application publication number 200610114616.7 discloses is a kind of " being used to improve the pharmaceutical composition that memory and treatment brain atrophy cause senile dementia ", and the primary raw material of this pharmaceutical composition comprises the Radix Astragali, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Fructus Lycii, Fructus Corni, Radix Puerariae, Fructus Crataegi, Rhizoma Gastrodiae, Bombyx Batryticatus, Rhizoma Acori Graminei and compound vitamin B and trace element chromium, zinc, selenium.Do not add lecithin and vitamin C, zinc and selenium neither be with the forms of yeast rich in zinc and yeast rich in selenium.
One Chinese patent application publication number 200410010931.6 discloses " medicine of a kind of person in middle and old age's of treatment hypomnesis and preparation method thereof "; This medicine is a primary raw material with Radix Panacis Quinquefolii, pig's brain powder, Radix Polygoni Multiflori, Fructus Alpiniae Oxyphyllae, Fructus Schisandrae Chinensis, Rhizoma Gastrodiae, Rhizoma Acori Graminei, Fructus Perillae, Radix Salviae Miltiorrhizae, Radix Polygalae, Radix Puerariae, serves as main different with the present invention to replenish brain nutrition.
Like health food " the clever capsule of doctor's board Xin Jinao difficult to understand ", its primary raw material is common perilla seed extract, taurine, zinc citrate, natural beta-carotin, vitamin A, stable vitamin B1, stable vitamin B2, vitamin B6, vitamin B12, stable vitamin C, folic acid, nicotiamide, lecithin, natural Vitamin E.There are not yeast rich in zinc and yeast rich in selenium.
Being known by above, is not this series products of primary raw material with yeast rich in zinc and yeast rich in selenium in the prior art.Major part is to be main with Chinese medicine ingredients, lecithin, vitamin E.
The present invention is a primary raw material with yeast rich in zinc and yeast rich in selenium, develops the product that a kind of suitable middle-aged and elderly people improves memory.Yeast rich in zinc is in the process of culture yeasts, to add zinc element; Through yeast absorption and conversion to zinc element in growth course; Intravital protein of zinc and yeast and polysaccharide organic are combined; Thereby inorganic zinc and the organic zinc of having eliminated chemical property stimulate the toxicity and the intestines and stomach of human body, make the zinc utilization that can more efficiently, more safely be absorbed by the body.The production of yeast rich in selenium is similar with it, has eliminated the toxicity of inorganic selenium, and more stable unsuitable oxidized.Other functional components of these article also comprise lecithin, vitamin B1, vitamin B2, vitamin B12 and vitamin C.
Summary of the invention
The invention solves the problems referred to above of the prior art.An object of the present invention is to provide having of a kind of suitable middle-aged and elderly people and improve the preparation of memory function, said preparation mainly comprises: the vitamin C of the vitamin B12 of the vitamin B2 of the vitamin B1 of the lecithin of the yeast rich in selenium of the yeast rich in zinc of (wt%) 2%～90%, 0.001～90wt%, 0.1～10wt%, 0.001～10wt%, 0.001～10wt%, 0.00002～0.05wt%, 0.1～30wt% by mass percentage.Through the rational proportion of above nutrient, make these article have the brain of providing nutrition, improve memory, prevent hypomnesis, the function of prevention senile dementia.This product characteristic is: it is a primary raw material with yeast rich in zinc, yeast rich in selenium, and comprises lecithin, vitamin B1, vitamin B2, vitamin B12, vitamin C.
In the specific embodiment of the present invention, said preparation can also be optional comprises other adjuvants.
In the specific embodiment of the present invention, said preparation is fit to multiple dosage form, can be granule, tablet, capsule or oral liquid.
In the specific embodiment of the present invention, the yeast rich in zinc in the said preparation also can replace with the nourishment intensifying agent with zinc that comprises amino-acid zinc, zinc sulfate, zinc gluconate or their mixture.
In the specific embodiment of the present invention, the adjuvant in the said preparation can be that food such as filler, excipient, binding agent, lubricant, coloring agent, correctives, sweeting agent, essence are used or pharmaceutic adjuvant.
In the specific embodiment of the present invention, other have the functional component that improves memory effect can also to add cephalin, choline, taurine, tryptophan, vitamin A, vitamin B6, ferrum etc. in the said preparation.
Preparation of the present invention can replenish brain nutrition from many aspects comprehensively, reaches and improves memory, prevents hypomnesis, the function of prevention senile dementia.In addition, prescription of the present invention is novel, scientific and reasonable, takes for a long time and is free from side effects.
According to another aspect; Provide a kind of preparation to have the method for the preparation that improves memory function; This method may further comprise the steps: after (a) lecithin, vitamin C, vitamin B 1, vitamin B2 and other optional adjuvants being pulverized with Universalpulverizer, sieve; (b) in the lecithin of handling well by formula ratio, vitamin C, vitamin B1, vitamin B2 and optional other adjuvants, adding yeast rich in zinc, yeast rich in selenium, vitamin B12 and optional starch prepares burden; And (c) material for preparing is dropped into comminutor and carry out pelletize.
According to the method for preparing preparation of the present invention; Wherein, step (a) and (b) in raw material form (wt%) by mass percentage as follows: by the yeast rich in zinc of quality 2～90%, 0.001～90% yeast rich in selenium, 0.1～10% lecithin, 0.001～10% vitamin B1,0.001～10% vitamin B2,0.00002～0.05% vitamin B12 and 0.1～30% vitamin C.
According to the method for preparing preparation of the present invention, wherein, can also optional other adjuvants of adding in step (b).
According to the method for preparing preparation of the present invention, wherein, the yeast rich in zinc in the said preparation can replace with the nourishment intensifying agent with zinc that is selected from the group of being made up of amino-acid zinc, zinc sulfate, zinc gluconate or their mixture.
According to the method for preparing preparation of the present invention, wherein, the adjuvant in the step (b) can be that food such as filler, excipient, binding agent, lubricant, coloring agent, correctives, sweeting agent, essence are used or pharmaceutic adjuvant.And binding agent can be 50% ethanol, 10% syrup or starch slurry of 10% or the like.
According to the method for preparing preparation of the present invention, wherein, in step (c), can also add cephalin, choline, taurine, tryptophan, vitamin A, vitamin B
6, ferrum etc. other have the functional component that improves memory effect.
According to a further aspect of the invention, the application of a kind of preparation in improving memory function is provided.Said preparation comprises: by the yeast rich in zinc of quality 2～90%, 0.001～90% yeast rich in selenium, 0.1～10% lecithin, 0.001～10% vitamin B1,0.001～10% vitamin B2,0.00002～0.05% vitamin B12,0.1～30% vitamin C and other optional adjuvants.
The specific embodiment
An object of the present invention is to provide having of a kind of suitable middle-aged and elderly people and improve the preparation of memory function, said preparation mainly comprises: the vitamin C of the vitamin B12 of the vitamin B2 of the vitamin B1 of the lecithin of the yeast rich in selenium of the yeast rich in zinc of (wt%) 2%～90%, 0.001～90wt%, 0.1～10wt%, 0.001～10wt%, 0.001～10wt%, 0.00002～0.05wt%, 0.1～30wt% by mass percentage.Through the rational proportion of above nutrient, make these article have the brain of providing nutrition, improve memory, prevent hypomnesis, the function of prevention senile dementia.This product characteristic is: it is a primary raw material with yeast rich in zinc, yeast rich in selenium, and comprises lecithin, vitamin B1, vitamin B2, vitamin B12, vitamin C.
In the specific embodiment of the present invention, said preparation can also be optional comprises adjuvant.
In the specific embodiment of the present invention, said preparation is fit to multiple dosage form, can be granule, tablet, capsule or oral liquid.
In the specific embodiment of the present invention, the yeast rich in zinc in the said preparation also can replace with the nourishment intensifying agent with zinc that comprises amino-acid zinc, zinc sulfate, zinc gluconate or their mixture.
In the specific embodiment of the present invention, the adjuvant in the said preparation can be that food such as filler, excipient, binding agent, lubricant, coloring agent, correctives, sweeting agent, essence are used or pharmaceutic adjuvant.
In the specific embodiment of the present invention, other have the functional component that improves memory effect can also to add cephalin, choline, taurine, tryptophan, vitamin A, vitamin B6, ferrum etc. in the said preparation.
According to another aspect, the method that provides a kind of preparation to have the preparation that improves memory function, this method may further comprise the steps: after (a) lecithin, vitamin C, vitamin B1, vitamin B2 and optional adjuvant being pulverized with Universalpulverizer, sieve; (b) in the lecithin of handling well by formula ratio, vitamin C, vitamin B1, vitamin B2 and optional adjuvant, adding yeast rich in zinc, yeast rich in selenium, vitamin B12 and optional starch prepares burden; And (c) material for preparing is dropped into comminutor and carry out pelletize.
According to the method for preparing preparation of the present invention; Wherein, step (a) and (b) in raw material form (wt%) by mass percentage as follows: by the yeast rich in zinc of quality 2～90%, 0.001～90% yeast rich in selenium, 0.1～10% lecithin, 0.001～10% vitamin B1,0.001～10% vitamin B2,0.00002～0.05% vitamin B12 and 0.1～30% vitamin C.
According to the method for preparing preparation of the present invention, wherein, can also optional adding adjuvant in step (b).
According to the method for preparing preparation of the present invention, wherein, the yeast rich in zinc in the said preparation can replace with other nourishment intensifying agent with zinc that are selected from the group of being made up of amino-acid zinc, zinc sulfate, zinc gluconate or their mixture.
According to the method for preparing preparation of the present invention, wherein, the adjuvant in the step (b) can be that food such as filler, excipient, binding agent, lubricant, coloring agent, correctives, sweeting agent, essence are used or pharmaceutic adjuvant.And binding agent can be 50% ethanol, 10% syrup or starch slurry of 10% etc.
According to the method for preparing preparation of the present invention, wherein, in step (c), can also add cephalin, choline, taurine, tryptophan, vitamin A, vitamin B
6, ferrum etc. other have the functional component that improves memory effect.
According to a further aspect of the invention, the application of a kind of preparation in improving memory function is provided.Said preparation comprises: by the yeast rich in zinc of quality 2～90%, 0.001～90% yeast rich in selenium, 0.1～10% lecithin, 0.001～10% vitamin B1,0.001～10% vitamin B2,0.00002～0.05% vitamin B12,0.1～30% vitamin C.
Preparation of the present invention can replenish brain nutrition from many aspects comprehensively, reaches and improves memory, prevents hypomnesis, the function of prevention senile dementia.In addition, prescription of the present invention is novel, scientific and reasonable, takes for a long time and is free from side effects.
Embodiment
Embodiment 1: the preparation of preparation of the present invention
At first, after the white sugar of the vitamin B2 of the vitamin B1 of the vitamin C of the lecithin of 2g, 3g, 0.05g, 0.05g, 40g pulverized with Universalpulverizer, cross 80 mesh sieves.
The configuration of binding agent: the syrup water of preparation 10%, add an amount of edible ethanol, filter, subsequent use.With the lecithin of handling well, vitamin C, vitamin B1, vitamin B2, white sugar etc., the yeast rich in zinc of adding 37.5g, the yeast rich in selenium of 2.5g, the vitamin B12 of 0.00004g, the starch of 14.9g are pressed the formula ratio mix homogeneously.The binding agent that configures is injected in the constant flow pump material tube.The mode mix homogeneously batching that vitamin B12 increases progressively according to equivalent after by the formula ratio weighing.
The material for preparing is dropped into one-step-granulating method, install the material pot, open blower fan, open steam valve, 80-100 ℃ of control EAT, leaving air temp 60-80 ℃, mixed 5 minutes, open the atomization system, granulate.Material granulating situation is observed in attention, and 40-60 minute, granulate after the completion, close atomization system, dry about 30 minutes, after survey moisture reaches 2-3%, discharging.
Dried granule adds proper amount of edible essence.Eating method: take 2g every day, use mixing in water for oral taking.
In view of the above, can obtain having the preparation of following characteristic: said preparation can replenish brain nutrition comprehensively, reach and improve the function of remembering, prevent hypomnesis, prevention senile dementia.
Similar operation above the inventor adopts changes the consumption of operating condition parameter and each raw material, and listed condition basically can embodiment of the present invention below finding to adopt.
Adopt above-mentioned identical step,, carry out the operation of embodiment 2-13 according to process conditions listed in the table 1.
Comparative example 1-4
Similar operation above the inventor adopts changes the consumption of operating condition parameter and each raw material.Particularly, the content with each composition in the prescription changes into outside the scope of the foregoing description.
Table 1
The application of preparation of the present invention
Prove that through functional experiment the present invention has the significant function of improving the mouse aging memory, and its effect increases than like product.Concrete experimental data is following:
1 material and method
1.1 animal
Choose healthy cleaning level 48 of Kunming kind white mice childhood (meeting Y type labyrinth test request), body weight (20 ± 2) g.Be divided into 6 groups at random; Every group 8 (male and female half and half); The 1st group is physiology saline control group, and the 2nd group is D-galactose aging model group, and the 3rd, 4 group of mice irritated stomach with improvement memory product of the present invention; This product is a primary raw material with yeast rich in zinc, yeast rich in selenium, and comprises lecithin, vitamin B1, vitamin B2, vitamin B12, vitamin C and optional adjuvant.The 3rd group of product that adds embodiment 1, the 4th group of product that adds embodiment 2.Dosage is taken 2g calculating according to 10 times of conversions of body weight and human body recommended amounts by human body body weight 50kg every day, then is 0.04mg/ (gd), and rat body weight is pressed 20g and calculated, and then is 8mg/d; 5th, irritate stomach with comparative example 1,2 products for 6 groups, dosage is identical with the 3rd, 4 group to be 8mg/d; 1st, 2 groups give the equal-volume normal saline, continuous 20 days.
1.2 method
1.2.1 aging model mice preparation
Irritate stomach beginning in the 11st day at the 3rd, 4,5,6 group; Simultaneously the 2nd group of aging model group, the 3rd, 4 group of improvement memory group of products, the 5th, 6 group of comparative example are irritated the stomach group mice subcutaneous injection D-L of every nape portion galactose (1g/kgd); Continuous 10 days, process mice aging model.
1.2.2Y type maze test
Adopt Y type maze method, it is the arm of three intercommunications that the labyrinth is divided into.Every arm end is provided with an active guard plate.During experiment test, be the starting area with A, B is the place of safety, and C is the hazardous area.Running voltage 20～30V.Mice is after being shocked by electricity in the starting area, and disposable race is gone into the place of safety for correct, otherwise is mistake, is disposable training.Train with B is the starting area next time, and C is the place of safety, and A is the hazardous area, and is reciprocal successively, in continuous 10 training of mice, has 9 times when correct, just thinks that mice learned leakage of electricity labyrinth, and the number of times of this moment is exactly that the required number of times in labyrinth is walked by association.Measure memory achievement (difference of learning the study number of times behind number of times and the 24h first time accounts for the percentage rate of learning number of times for the first time) behind the 24h.
1.2.3 the mensuration of serum and cerebral tissue antioxidation index
The mouse carotid arterial blood extracting was used anticoagulant heparin in the 22nd day, anticoagulation is put into seperator, with the centrifugal 15min of 3000r/min, separation of serum.And quick sacrificed by decapitation, get its cerebral tissue and process 10% brain homogenate.SOD in detection brain homogenate and the serum is active, GSH-Px is active and MDA content.
2 results
2.1 improve of the influence of memory product to the aging model learning and memory of little mouse
Compare with matched group, aging model group mice learning and memory ability obviously fails, and showing as the study number of times significantly increases (P＜0.01), remembers the reduction (P＜0.05) of making outstanding achievements, and is consistent with the old and feeble rule of mice.Compare with aging model, irritate stomach group (the 3rd, 4 group) and obviously reduce (P＜0.01) with the study number of times that comparative example is irritated stomach group (the 5th, 6 group) with improving the memory product, the memory achievement also significantly improves (P＜0.01).And irritate stomach group (the 3rd, 4 group) and irritate stomach group (the 5th, 6 group) comparative learning number of times with comparative example and significantly reduce (P＜0.01) with improving the memory product, memory achievement be significantly increased (P＜0.05).The result sees table 1.
Table 1 aging model mice Y type maze test result (x ± s)
Compare with matched group: a) P＜0.05, b) P＜0.01
Compare with the aging model group: c) P＜0.01
Compare with the 5th, 6 group: d) P＜0.01, e) P＜0.05
2.2 improve of the influence of memory product to SOD, GSH-Px activity and MDA content in the aging model mice serum
Compare with matched group, aging model group mice serum SOD and GSH-Px activity all significantly reduce (P＜0.05), and the content of MAD significantly raises (P＜0.01), and be consistent with the old and feeble rule of mice.Compare with the aging model group, irritate stomach group (the 3rd, 4 group) and significantly improve (P＜0.01) with SOD and GSH-Px activity in comparative example filling stomach group (the 5th, the 6 group) mice serum with improving the memory product, the content of MDA significantly reduces (P＜0.01).And with improve the memory product irritate stomach group (the 3rd, 4 group) and with comparative example irritate stomach group (the 5th, 6 group) relatively in the mice serum SOD and GSH-Px activity significantly improve (P＜0.05), the content of MDA significantly reduces (P＜0.05).The result sees table 2.
SOD and GSH-Px activity and MDA assay result in the table 2 aging model mice serum (x ± s)
(U/ml×10
2)
Compare with matched group: a) P＜0.05, b) P＜0.01
Compare with the aging model group: c) P＜0.05, d) P＜0.01
Compare with the 5th, 6 group: e) P＜0.05
2.3 improve of the influence of memory product to SOD, GSH-Px activity and MDA content in the aging model mouse brain tissue
Compare with matched group, aging model group mouse brain tissue SOD and GSH-Px activity all significantly reduce (P＜0.01), and the content of MAD significantly raises (P＜0.01), and be consistent with the old and feeble rule of mice.Compare with the aging model group, irritate stomach group (the 3rd, 4 group) and significantly improve (P＜0.01) with SOD and GSH-Px activity in comparative example filling stomach group (the 5th, 6 group) the mouse brain tissue with improving the memory product, the content of MDA significantly reduces (P＜0.01).And irritate stomach group (the 3rd, 4 group) and significantly improve (P＜0.05) with SOD and GSH-Px activity in the smaller murine brain of comparative example filling stomach group (the 5th, 6 group) with improving the memory product, the content of MDA significantly reduces (P＜0.05).The result sees table 3.
SOD and GSH-Px activity and MDA assay result in the table 3 aging model mouse brain tissue (x ± s)
(U/ml×10
2)
Compare with matched group: a) P＜0.01
Compare with the aging model group: c) P＜0.05, d) P＜0.01
Compare with the 5th, 6 group: e) P＜0.05
This experiment prepares aging model through giving injected in mice D-L galactose; Then to mice with improving memory group of products (the 3rd, 4 group) and, with SOD and GSH-Px activity and MDA content in matched group comparative learning memory ability and serum, the cerebral tissue with comparative example (the 5th, 6 group) filling stomach.Experimental result shows; SOD of mice and GSH-Px are active after the injected in mice D-L galactose reduces; MDA content raises, and explains that thus obvious decline of aging model group learning and memory abilities in aging mice causes the excessive accumulation of interior free yl relevant with the reduction of antioxidant ability of organism.And after improving the memory group of products and irritating stomach with the comparative example group; Ability of learning and memory obviously improves; The SOD of mice and GSH-Px are active significantly to raise, and MDA content significantly reduces, and explain to improve and remembers group of products and with the comparative example group memory impairments that all improves significantly.And improvement memory product of the present invention and comparative example 1,2 are relatively, and each item index all has clear improvement, and explains that this product is significantly increased than the effect of like product.
Though only provided above with the research of the product of embodiment 1 and 2, adopted the product of other embodiment also can obtain similar effects as feedstuff as feedstuff.
Though describe and the present invention be described through specific embodiment, should be appreciated that for a person skilled in the art, under the situation that does not deviate from the spirit and scope of the present invention, can carry out various modifications and be equal to replacement the present invention.Therefore, the invention is not restricted to the specific embodiment described in this article.More properly, protection scope of the present invention is limited by the accompanying claims.
Claims (8)
1. one kind has the preparation that improves memory function, and said preparation is by processing by the yeast rich in zinc of quality 2%～90%, 0.001%～90% yeast rich in selenium, 0.1%～10% lecithin, 0.001%～10% vitamin B 1,0.001%～10% vitamin B2,0.00002%～0.05% vitamin B12 and 0.1%～30% vitamin C and adjuvant.
2. preparation according to claim 1, wherein, the adjuvant in the said preparation can be filler, excipient, binding agent, lubricant, coloring agent, correctives.
3. preparation according to claim 1, wherein, the adjuvant in the said preparation can be sweeting agent, essence.
4. one kind prepares according to each described method with the preparation that improves memory function among the claim 1-3, said method comprising the steps of:
(1) lecithin, vitamin C, vitamin B1, vitamin B2 and adjuvant are pulverized with Universalpulverizer after, sieve;
(2) lecithin of handling well, vitamin C, vitamin B1, vitamin B2, adjuvant and yeast rich in zinc, yeast rich in selenium, vitamin B12 and optional adjuvant are prepared burden by the formula ratio mix homogeneously; And
(3) with after granulating in the material input one-step-granulating method for preparing, go out grain.
5. method according to claim 4; Wherein, (wt%) as follows by by mass percentage for said preparation: 2%～90% yeast rich in zinc, 0.001%～90% yeast rich in selenium, 0.1%～10% lecithin, 0.001%～10% vitamin B1,0.001%～10% vitamin B2,0.00002%～0.05% vitamin B12 and 0.1%～30% vitamin C and adjuvant are processed.
6. method according to claim 4, wherein, the adjuvant in the said preparation can be filler, excipient, binding agent, lubricant, coloring agent, correctives.
7. method according to claim 4, wherein, the adjuvant in the said preparation can be sweeting agent, essence.
8. be used for improving the application of the medicine of memory function in preparation according to each described preparation among the claim 1-3.
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| CN101766659A (en) | 2010-07-07 |
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