CN103948029B - A kind of yin-deficiency constitution protective foods and its preparation method - Google Patents
A kind of yin-deficiency constitution protective foods and its preparation method Download PDFInfo
- Publication number
- CN103948029B CN103948029B CN201410182009.9A CN201410182009A CN103948029B CN 103948029 B CN103948029 B CN 103948029B CN 201410182009 A CN201410182009 A CN 201410182009A CN 103948029 B CN103948029 B CN 103948029B
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- protective foods
- weight part
- yin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000013305 food Nutrition 0.000 title claims abstract description 61
- 230000001681 protective effect Effects 0.000 title claims abstract description 56
- 208000031971 Yin Deficiency Diseases 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 239000003814 drug Substances 0.000 claims abstract description 56
- 241000628997 Flos Species 0.000 claims abstract description 43
- 229940079593 drug Drugs 0.000 claims abstract description 33
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 25
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 24
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 24
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 24
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 23
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 23
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 23
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 23
- 240000000249 Morus alba Species 0.000 claims abstract description 21
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 21
- 239000004615 ingredient Substances 0.000 claims abstract description 3
- 239000000284 extract Substances 0.000 claims description 156
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 48
- 239000000843 powder Substances 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000005913 Maltodextrin Substances 0.000 claims description 21
- 229920002774 Maltodextrin Polymers 0.000 claims description 21
- 229940035034 maltodextrin Drugs 0.000 claims description 21
- 210000000582 semen Anatomy 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 20
- 229930189775 mogroside Natural products 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 14
- 239000000230 xanthan gum Substances 0.000 claims description 14
- 229920001285 xanthan gum Polymers 0.000 claims description 14
- 229940082509 xanthan gum Drugs 0.000 claims description 14
- 235000010493 xanthan gum Nutrition 0.000 claims description 14
- 239000002002 slurry Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 4
- 229960004106 citric acid Drugs 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 230000002572 peristaltic effect Effects 0.000 claims description 3
- 230000000630 rising effect Effects 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 2
- 238000003809 water extraction Methods 0.000 claims description 2
- 210000000952 spleen Anatomy 0.000 abstract description 26
- 210000003734 kidney Anatomy 0.000 abstract description 24
- 210000001124 body fluid Anatomy 0.000 abstract description 17
- 239000010839 body fluid Substances 0.000 abstract description 17
- 210000002784 stomach Anatomy 0.000 abstract description 15
- 210000004185 liver Anatomy 0.000 abstract description 14
- 238000004519 manufacturing process Methods 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 11
- 230000001105 regulatory effect Effects 0.000 abstract description 7
- 230000035622 drinking Effects 0.000 abstract description 2
- 235000008216 herbs Nutrition 0.000 abstract description 2
- 230000010354 integration Effects 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 47
- 239000000047 product Substances 0.000 description 37
- 230000007812 deficiency Effects 0.000 description 21
- 238000001914 filtration Methods 0.000 description 16
- 238000005507 spraying Methods 0.000 description 16
- 210000004072 lung Anatomy 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 13
- 239000008280 blood Substances 0.000 description 13
- 235000008504 concentrate Nutrition 0.000 description 12
- 239000012141 concentrate Substances 0.000 description 12
- 239000006071 cream Substances 0.000 description 12
- 235000014666 liquid concentrate Nutrition 0.000 description 12
- 241000700159 Rattus Species 0.000 description 9
- 230000008901 benefit Effects 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 206010010356 Congenital anomaly Diseases 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 235000019640 taste Nutrition 0.000 description 5
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 4
- 241000721047 Danaus plexippus Species 0.000 description 4
- 241000218231 Moraceae Species 0.000 description 4
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 4
- 206010003549 asthenia Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000003304 gavage Methods 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 229940034208 thyroxine Drugs 0.000 description 4
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 208000009205 Tinnitus Diseases 0.000 description 3
- 206010047513 Vision blurred Diseases 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 230000006735 deficit Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- 206010013781 dry mouth Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000007958 sleep Effects 0.000 description 3
- 230000009182 swimming Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 231100000886 tinnitus Toxicity 0.000 description 3
- 235000007516 Chrysanthemum Nutrition 0.000 description 2
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- 235000009815 Momordica Nutrition 0.000 description 2
- 241000218984 Momordica Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000700157 Rattus norvegicus Species 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000002929 anti-fatigue Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 206010021033 Hypomenorrhoea Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 235000020965 cold beverage Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 230000005059 dormancy Effects 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 238000009661 fatigue test Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a kind of yin-deficiency constitution protective foods and its preparation method, this protective foods as active drug component and allows the auxiliary added ingredients used to form taking integration of drinking and medicinal herbs raw material sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, Flos Chrysanthemi and Chinese yam in medicine and food, consists of with the crude drug raw material of each effective medicine-food two-purpose component of parts by weight: sealwort 100��300 parts, 22.5��90 parts, mulberry fruit, radix polygonati officinalis 17.5��70 parts, 16��120 parts, lotus seeds, Flos Chrysanthemi 20��60 parts and Chinese yam 18��72 parts. This protective foods, for yin-deficiency constitution crowd, has nourishing liver and kidney, promotes the production of body fluid and moisturize, effect of function of spleen and stomach regulating.
Description
Technical field
The present invention relates to a kind of integration of drinking and medicinal herbs protective foods and its preparation method, it is specifically related to for yin-deficiency constitution protective foods and its preparation method.
Background technology
Physique is formed by obtaining congenital heredity and the day after tomorrow, and individual characteristic intrinsic, relatively stable in morphological structure and functional activity, has dependency with psychology personality. Individual physique is different, shows as some otherness in the reaction and adaptability that stimulate to external world under physiological status, and to the susceptibility of some virulence factor and the proneness of disease progression in pathogenic process.
Tcm constitution theory springs from "Nei Jing", to the constitutive character of individual and different groups, the formation of physique, the somatotype of physique and all have detailed elaboration with the problem such as the relation of disease development, the control of disease in "Nei Jing". The body and the spirit space formation of Constitution Theory in TCM is thought, physique is the synthesis of specific body quality and certain psychological quality, embodies " unity of body and soul " thought of the traditional Chinese medical science.
Tcm constitution classification establishes taking basic substance one yin, yang of human life activity, gas, blood, body fluid prosperity and decline state as foundation, just because of in body, the prosperity and decline state of yin, yang, gas, blood, body fluid is different, thus show as the physique otherness between individuality.
The traditional Chinese medical science, to the understanding of yin-deficiency constitution, starts from "Nei Jing". Owing to the cloudy liquid such as body fluid essence blood in body lose few, show as the constitution status of main feature with yin asthenia generating intrinsic heat etc. The deficiency of Yin, refers to the YIN-fluid being insufficient such as the essence of body, blood, seminal fluid. People's disposition of yin-deficiency constitution is more irritable, usually susceptible to lose temper due to restlessness. Showing as emaciated physique, complexion flush, dryness of the mouth and throat, tired time in the heart, feverish sensation in the palms and soles, few dormancy, just does, and urine is yellow, not resistance to spring and summer, many desire for cold drinkss, thready and rapid pulse, the red few tongue of tongue. If ill, above-mentioned all diseases are more obvious, or lack phlegm with dry cough, hectic fever night sweat (deficiency of lung-YIN); Or palpitation and amnesia, insomnia and dreamful sleep (deficiency of heart-yin); Or have a pain in the back, dizzy tinnitus, man passes out semen, woman's Hypomenorrhea (deficiency of the kidney yin); Or hypochondriac pain, blurring of vision (deficiency of liver-YIN). The main subhealth symptom of yin-deficiency constitution sums up the Three Character Primer: deficiency of Yin matter, olighydria, five heart heat, dry mouth and throat.
At present, for improving yin-deficiency constitution symptom, have nourishing liver and kidney, promote the production of body fluid and moisturize, function of spleen and stomach regulating effect be all some Chinese medicines, mouthfeel is poor, takes inconvenience.
Summary of the invention
For the problems referred to above of prior art, the present invention provides a kind of for yin-deficiency constitution, has nourishing liver and kidney, promotes the production of body fluid and moisturize, the protective foods of function of spleen and stomach regulating effect and its preparation method.
For achieving the above object, the present invention comprises following technical scheme:
A kind of yin-deficiency constitution protective foods, it as active drug component and allows the auxiliary added ingredients used to form taking the extract of medicine and food raw materials sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, Flos Chrysanthemi and Chinese yam in medicine and food, consists of with the crude drug raw material of each effective medicine-food two-purpose component of parts by weight: sealwort 100��300 parts, 22.5��90 parts, mulberry fruit, radix polygonati officinalis 17.5��70 parts, 16��120 parts, lotus seeds, Flos Chrysanthemi 20��60 parts and Chinese yam 18��72 parts.
Protective foods as above, preferably, the described crude drug raw material with each effective medicine-food two-purpose component of parts by weight consists of: sealwort 150��250 parts, 45��67.5 parts, mulberry fruit, radix polygonati officinalis 28��52.5 parts, 40��80 parts, lotus seeds, Flos Chrysanthemi 32��40 parts and Chinese yam 30��48 parts.
Protective foods as above, it may be preferred that the described crude drug raw material with each effective medicine-food two-purpose component of parts by weight consists of: sealwort 240 parts, 60 parts, mulberry fruit, radix polygonati officinalis 36 parts, 60 parts, lotus seeds, Flos Chrysanthemi 36 parts and and Chinese yam 36 parts.
Protective foods as above, preferably, the weight part composition and ratio of described active drug component is: Rhizoma Polygonati extract 20��60 parts, Fructus Mori extract 5��20 parts, Rhizoma Polygonati Odorati extract 5��20 parts, Semen Nelumbinis extract 2��15 parts, Flos Chrysanthemi extract 5��15 parts and Rhizoma Dioscoreae extract 3��12 parts.
Protective foods as above, preferably, the weight part composition and ratio of described active drug component is: Rhizoma Polygonati extract 30��50 parts, Fructus Mori extract 10��15 parts, Rhizoma Polygonati Odorati extract 8��15 parts, Semen Nelumbinis extract 5��10 parts, Flos Chrysanthemi extract 8��10 parts and Rhizoma Dioscoreae extract 5��8 parts.
Protective foods as above, preferably, the weight part composition and ratio of described active drug component is: Rhizoma Polygonati extract 48 parts, Fructus Mori extract 13.33 parts, Rhizoma Polygonati Odorati extract 10.29 parts, Semen Nelumbinis extract 7.5 parts, Flos Chrysanthemi extract 9 parts and Rhizoma Dioscoreae extract 6 parts.
Protective foods as above, it may be preferred that the extracting method of described each extract is as follows: sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, Flos Chrysanthemi and Chinese yam all use boil water extraction method to obtain extract.
Protective foods as above, it may be preferred that also containing auxiliary material in this protective foods, select one or more in white maltodextrin, xanthan gum, Citric Acid, usp, Anhydrous Powder and mogroside.
Protective foods as above, it may be preferred that the preparation method of described Rhizoma Polygonati extract is as follows:
Sealwort decoction piece, adds 4-10 times amount water boil and extracts 0.5-2 hour, extract 1-3 time, extracting liquid filtering, merge filtered liquid for subsequent use; Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; The 5-15% maltodextrin that centrifugate adds finished product amount is dry to spray-dryer after mixing, and spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Rhizoma Polygonati extract.
Protective foods as above, it may be preferred that the preparation method of described Fructus Mori extract is as follows:
Mulberries medicine materical crude slice, adds 4-10 times amount water boil and extracts 0.5-2 hour, extract 1-3 time, extracting liquid filtering, merge filtered liquid for subsequent use; Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; The 30-35% maltodextrin that centrifugate adds finished product amount is dry to spray-dryer after mixing, and spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain mulberries extract.
Protective foods as above, it may be preferred that the preparation method of described Rhizoma Polygonati Odorati extract is as follows:
Radix polygonati officinalis medicine materical crude slice, adds 4-10 times amount water boil and extracts 0.5-2 hour, extract 1-3 time, extracting liquid filtering, merge filtered liquid for subsequent use; Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; The 13-19% maltodextrin that centrifugate adds finished product amount is dry to spray-dryer after mixing, and spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Rhizoma Polygonati Odorati extract.
Protective foods as above, it may be preferred that the preparation method of described Semen Nelumbinis extract is as follows:
Lotus seeds medicine materical crude slice, adds 4-10 times amount water boil and extracts 0.5-2 hour, extract 1-3 time, extracting liquid filtering, merge filtered liquid for subsequent use; Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; The 30-35% maltodextrin that centrifugate adds finished product amount is dry to spray-dryer after mixing, and spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Semen Nelumbinis extract.
Protective foods as above, it may be preferred that the preparation method of described Rhizoma Dioscoreae extract is as follows:
Chinese yam medicine materical crude slice, adds 4-10 times amount water boil and extracts 0.5-2 hour, extract 1-3 time, united extraction liquid, filter, and filtered liquid is for subsequent use; Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; Centrifugate spraying dry, spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Rhizoma Dioscoreae extract.
Protective foods as above, it may be preferred that the preparation method of described Flos Chrysanthemi extract is as follows:
Flos Chrysanthemi, adds 4-10 times amount water boil and extracts 0.5-2 hour, extract 1-3 time, united extraction liquid, filter, and filtered liquid is for subsequent use; Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; Centrifugate spraying dry, spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Flos Chrysanthemi extract.
Protective foods as above, it may be preferred that containing maltodextrin 20��60 parts, xanthan gum 0.5��2.5 part, Citric Acid, usp, Anhydrous Powder 0.5��2.5 part and mogroside 0.5��2.0 part in the protective foods of every 100 weight parts.
The protective foods of the present invention, for yin-deficiency constitution crowd, can increase according to corresponding ratio when producing or reduce, as scale operation can by kilogram or in units of ton, small-scale production can also be in grams, weight can increase or reduce, but raw material weight ratio between each composition is constant.
On the other hand, the present invention provides the preparation method of protective foods described above, and the method comprises the following steps: described Citric Acid, usp, Anhydrous Powder and mogroside is added water and makes slurry; Rhizoma Polygonati extract, Fructus Mori extract, Flos Chrysanthemi extract, Rhizoma Polygonati Odorati extract, Semen Nelumbinis extract, Rhizoma Dioscoreae extract, xanthan gum, maltodextrin are dropped in nodulizer successively and mixes; treat that inlet temperature rises to 55��85 DEG C; regulate the whitewashing of peristaltic pump rotating speed; the Grosvenor Momordica slurry made, citric acid slurry are successively sprayed in boiling granulating machine; rising granulation; sieve, filling, to obtain final product.
Another further aspect, the present invention provides the application of protective foods as above in preparation yin-deficiency constitution protective foods and medicine.
Application as above, it may be preferred that the dosage of described protective foods is 3-15g/ days.
The present invention is directed to yin-deficiency constitution crowd, have nourishing liver and kidney, promote the production of body fluid and moisturize, the protective foods of function of spleen and stomach regulating effect, its useful effect is, formulating of recipe adopts the skeleton construction of Chinese materia medica " monarch, minister, help, make ". Monarch's medicine sealwort, can not only the moon of nourishing lung and kidney, and can invigoration spleen qi spleen cloudy, have and mend autochthonal gold, mend the day after tomorrow to support congenital effect. And dirty same benefit of lung spleen kidney three is monarch's medicine. Radix polygonati officinalis, mulberry fruit, lotus seeds are minister, nourishing YIN to relieve dryness, and cool blood enriching blood and promoting secretion of body fluid, can prevent and treat yin asthenia generating intrinsic heat. Flos Chrysanthemi is adjutant, deficiency of YIN bringing about interior heat, less compatibility chrysanthemum can heat-clearing, prevent heat impairment of yin again. Stomach nourishing Chinese yam is good for spleen, and the taste of anti-monarch-minister drug is greasy, for making medicine. All medicines share, not only mended congenital, but also mend the day after tomorrow, liver, stomach, lung are taken into account simultaneously, and five cloudy also mend. Play nourishing liver and kidney altogether, promote the production of body fluid and moisturize, the merit of function of spleen and stomach regulating. Alleviating the main subhealth symptom of yin-deficiency constitution crowd, show as dry mouth and throat, be hard and dry, order is done, and complexion flush, warms sense, blurring of vision, dizzy tinnitus, and To Be Protected from Heat, sleeps poor, easily irritability etc.
The protective foods of the present invention is eaten material with medicine-food two-purpose and is carried out compatibility, nurses one's health the biased of human body constitution, and curative effect is reliable, has no side effect, and taste is acceptant, containing any sanitas, synthetic colour, compound essence, has good stability, is convenient to carry.
Embodiment
The main raw material of the present invention is sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, Flos Chrysanthemi and Chinese yam.
Sealwort: return spleen, lung, kidney three warp, nourshing kidney profit spleen, boosting qi and nourishing yin, strong spleen, moistening lung, benefit kidney.
Mulberry fruit: the thoughts of returning home, liver, kidney channel, sweet in flavor and cold in property, there is liver-kidney tonifying, ease constipation of promoting the production of body fluid, crow effect such as invention order.
Radix polygonati officinalis: property is sweet, micro-cold, attaches to the lung and stomach meridians, and nourishing YIN to relieve dryness, promotes the production of body fluid to quench thirst.
Lotus seeds: return spleen, kidney, the heart channel of Hang-Shaoyin. Tonifying spleen antidiarrheal, the benefit puckery essence of kidney, tranquilizing by nourishing the heart.
Flos Chrysanthemi: sweet, bitter, micro-cold, return lung, Liver Channel. Loose wind heat-clearing, flat liver item.
Chinese yam: sweet, flat. Return spleen, lung, kidney essense. Tonifying spleen nourishing the stomach, benefit of promoting the production of body fluid lung, the puckery essence of kidney tonifying.
Mogroside, in the present invention as low calorie sweetener.
Fang Zhongjun medicine sealwort is sweet, flat, boosting qi and nourishing yin, strong spleen, moistening lung, benefit kidney. Sealwort can not only the moon of nourishing lung and kidney, and can invigoration spleen qi spleen cloudy, have and mend autochthonal gold, mend the day after tomorrow to support congenital effect. And dirty same benefit of lung spleen kidney three is monarch's medicine. As Compendium of Material Medica says it: " mending all void ... replenishing essence marrow ". Fructus Mori is sweet, sour, cold, can nourishing YIN and supplementing blood, promote the production of body fluid and moisturize, and can relax bowel, cool blood bring down a fever, for the dry person of thirsty, yin asthenia generating intrinsic heat glycosuria patient and constipation matter, especially suitable, such as " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " benefit kidney and controlling nocturnal emission with astringent drugs take black invention order for a long time. " " Bencao Jingshu ": " and for cool blood enrich blood benefit the moon medicine ". The people of yin-deficiency constitution, this deficiency of Yin sick, then impairment of yin dryness-transformation, traces sth. to its source for a long time, all caused by the insufficiency of blood of edge Tianjin, treating dryness syndrome by moistening. Radix polygonati officinalis property is sweet, micro-cold, attaches to the lung and stomach meridians, and nourishing YIN to relieve dryness, promotes the production of body fluid to quench thirst. Lotus seeds can clear away heart-fire tonifying spleen, and tranquilizing by nourishing the heart, radix polygonati officinalis, mulberry fruit, lotus seeds are minister, nourishing YIN to relieve dryness, and cool blood enriching blood and promoting secretion of body fluid, can prevent and treat yin asthenia generating intrinsic heat. Flos Chrysanthemi is adjutant, deficiency of YIN bringing about interior heat, less compatibility chrysanthemum can heat-clearing, prevent heat impairment of yin again. The many tastes of enriching yin Chinese medicine are greasy, are easy to block up taste, affect ascending or descending movement of vital Qi, and stomach nourishing Chinese yam is good for spleen, and the taste of anti-monarch-minister drug is greasy, for making medicine.
All medicines share, not only mended congenital, but also mend the day after tomorrow, liver, stomach, lung are taken into account simultaneously, and five cloudy also mend. Play nourishing liver and kidney altogether, promote the production of body fluid and moisturize, the merit of function of spleen and stomach regulating. Alleviating the main subhealth symptom of yin-deficiency constitution crowd, show as dry mouth and throat, be hard and dry, order is done, and complexion flush, warms sense, blurring of vision, dizzy tinnitus, and To Be Protected from Heat, sleeps poor, easily irritability etc. (LIUWEI DIHUANG WAN is the substantially square of yin-deficiency constitution, six glutinous rehmannia ball kidney tonifying, liver, spleen three are cloudy, and this dietotherapy side kidney, liver, spleen, the heart, lung five is cloudy and mends, and do not have LIUWEI DIHUANG WAN to take the injury to stomach for a long time, edible gentle safety, the sub-health state of conditioning yin-deficiency constitution crowd comprehensively. )
Six medicines share to be played altogether: nourishing liver and kidney, promotes the production of body fluid and moisturizes, the merit of function of spleen and stomach regulating.
Following examples are for illustration of the present invention, but are not used for limiting the scope of the invention. Following examples are used source or the preparation method of raw material as follows:
1, the preparation method of Rhizoma Polygonati extract
Sealwort decoction piece adds 8, and times amount water boil extracts 1.5 hours, extracting liquid filtering, and the dregs of a decoction add 6, and times amount water boil extracts 1 hour, extracting liquid filtering, merges filtered liquid for subsequent use. Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; 10% maltodextrin that centrifugate adds finished product amount is dry to spray-dryer after mixing, and spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Rhizoma Polygonati extract. Through above-mentioned steps, every 100 weight part crude drug raw materials obtain extract about 20 weight part.
2, the preparation method of Fructus Mori extract
Mulberries medicine materical crude slice adds 8, and times amount water boil extracts 1.5 hours, extracting liquid filtering, and the dregs of a decoction add 6, and times amount water boil extracts 1 hour, extracting liquid filtering, merges filtered liquid for subsequent use. Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; 33% maltodextrin that centrifugate adds finished product amount is dry to spray-dryer after mixing, and spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain mulberries extract. Through above-mentioned steps, every 100 weight part crude drug raw materials obtain extract about 22.2 weight part.
3, the preparation method of Rhizoma Polygonati Odorati extract
Radix polygonati officinalis, times amount water boil extracts 1.5 hours to add 8, extracting liquid filtering, and the dregs of a decoction add 6, and times amount water boil extracts 1 hour, extracting liquid filtering, merges filtered liquid for subsequent use. Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; 16% maltodextrin that centrifugate adds finished product amount is dry to spray-dryer after mixing, and spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Rhizoma Polygonati Odorati extract. Through above-mentioned steps, every 100 weight part crude drug raw materials obtain extract about 28.6 weight part.
4, the preparation method of Semen Nelumbinis extract
Lotus seeds medicine materical crude slice adds 8, and times amount water boil extracts 1.5 hours, extracting liquid filtering, and the dregs of a decoction add 6, and times amount water boil extracts 1 hour, extracting liquid filtering, merges filtered liquid for subsequent use. Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; 33% maltodextrin that centrifugate adds finished product amount is dry to spray-dryer after mixing, and spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Semen Nelumbinis extract. Through above-mentioned steps, every 100 weight part crude drug raw materials obtain extract about 12.5 weight part.
5, the preparation method of Rhizoma Dioscoreae extract
Chinese yam, times amount water boil extracts 1.5 hours to add 8, extracting liquid filtering, and the dregs of a decoction add 6, and times amount water boil extracts 1 hour, extracting liquid filtering, merges filtered liquid for subsequent use. Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; Centrifugate spraying dry, spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Rhizoma Dioscoreae extract. Through above-mentioned steps, every 100 weight part crude drug raw materials obtain extract about 16.7 weight part.
6, the preparation method of Flos Chrysanthemi extract
Flos Chrysanthemi, times amount water boil extracts 1.5 hours to add 6, extracting liquid filtering, and the dregs of a decoction add 6, and times amount water boil extracts 1 hour, extracting liquid filtering, merges filtered liquid for subsequent use; Filtered liquid concentrates, and concentrates to proportion 1.06-1.14; Concentrated solution whizzer is centrifugal, and extracting centrifugal liquid is for subsequent use; Centrifugate spraying dry, spray-dryer inlet temperature is 180-205 DEG C, and air outlet temperature is 90-105 DEG C; Get spraying dry gained dried cream powder broken, cross 80 order sieves, obtain Flos Chrysanthemi extract. Through above-mentioned steps, every 100 weight part crude drug raw materials obtain Flos Chrysanthemi extract about 25 weight part.
7, mogroside is commercial, buys plant extract technology company limited of the vertical China in white Ningbo, lot number 20131001.
Embodiment 1: the protective foods () of yin-deficiency constitution
1, crude drug raw material composition: sealwort 240 weight part, radix polygonati officinalis 36 weight part, mulberry fruit 60 weight part, lotus seeds 60 weight part, Flos Chrysanthemi 36 weight part, Chinese yam 36 weight part;
Make the composition after extract: Rhizoma Polygonati extract 48 weight part, Rhizoma Polygonati Odorati extract 10.29 weight part, Fructus Mori extract 13.33 weight part, Semen Nelumbinis extract 7.5 weight part, Flos Chrysanthemi extract 9 weight part, Rhizoma Dioscoreae extract 6 weight part;
Auxiliary material: maltodextrin 51.99 weight part, xanthan gum 1.5 weight part, Citric Acid, usp, Anhydrous Powder 1.5 weight part and mogroside 0.9 weight part.
2, preparation process:
1) weigh: total charging capacity 150kg, weigh according to formula ratio, for subsequent use.
2) sieve: xanthan gum crosses 80 order sieves, for subsequent use.
3) slurrying: by the citric acid of formula ratio and mogroside, is dissolved in the water of prescription gross weight 15%, for subsequent use.
4) boiling granulating: Rhizoma Polygonati extract, Fructus Mori extract, Rhizoma Polygonati Odorati extract, Semen Nelumbinis extract, Flos Chrysanthemi extract, Rhizoma Dioscoreae extract, xanthan gum, maltodextrin are dropped in nodulizer successively. First blowing and mix for 10 minutes, treat that inlet temperature rises to 76 DEG C, be adjusted to peristaltic pump rotating speed, Grosvenor Momordica slurry step 3 made and citric acid slurry spray in boiling granulating machine, and rising granulation, material moisture is less than 4% discharging.
5) sieve: 20 order vibratory screening apparatuss.
6) filling (internal packing): to carry out filling with 10 row machines, 5g/ bag, obtain product 1.
Embodiment 2: the protective foods (two) of yin-deficiency constitution
1, crude drug raw material composition: sealwort 200 weight part, radix polygonati officinalis 70 weight part, mulberry fruit 22.5 weight part, lotus seeds 120 weight part, Flos Chrysanthemi 60 weight part, Chinese yam 72 weight part;
Make the composition after extract: Rhizoma Polygonati extract 40 weight part, Rhizoma Polygonati Odorati extract 20 weight part, Fructus Mori extract 5 weight part, Semen Nelumbinis extract 15 weight part, Flos Chrysanthemi extract 15 weight part, Rhizoma Dioscoreae extract 12 weight part;
Auxiliary material: maltodextrin 60 weight part, xanthan gum 2.5 weight part, Citric Acid, usp, Anhydrous Powder 2.5 weight part and mogroside 1.8 weight part.
2, the operation identical with embodiment 1 preparation process is adopted to prepare the protective foods (product 2) of yin-deficiency constitution.
Embodiment 3: the protective foods (three) of yin-deficiency constitution
1, crude drug raw material composition: sealwort 150 weight part, radix polygonati officinalis 17.5 weight part, mulberry fruit 45 weight part, lotus seeds 40 weight part, Flos Chrysanthemi 32 weight part, Chinese yam 30 weight part;
Make the composition after extract: Rhizoma Polygonati extract 30 weight part, Rhizoma Polygonati Odorati extract 5 weight part, Fructus Mori extract 10 weight part, Semen Nelumbinis extract 5 weight part, Flos Chrysanthemi extract 8 weight part, Rhizoma Dioscoreae extract 5 weight part;
Auxiliary material: maltodextrin 25 weight part, xanthan gum 0.6 weight part, Citric Acid, usp, Anhydrous Powder 0.5 weight part and mogroside 0.6 weight part.
2, the operation identical with embodiment 1 preparation process is adopted to prepare the protective foods (product 3) of yin-deficiency constitution. Embodiment 4: the protective foods (four) of yin-deficiency constitution
1, crude drug raw material composition: sealwort 225 weight part, radix polygonati officinalis 52.5 weight part, mulberry fruit 67.5 weight part, lotus seeds 80 weight part, Flos Chrysanthemi 40 weight part, Chinese yam 48 weight part;
Make the composition after extract: Rhizoma Polygonati extract 45 weight part, Rhizoma Polygonati Odorati extract 15 weight part, Fructus Mori extract 15 weight part, Semen Nelumbinis extract 10 weight part, Flos Chrysanthemi extract 10 weight part, Rhizoma Dioscoreae extract 8 weight part;
Auxiliary material: maltodextrin 55 weight part, xanthan gum 2 weight part, Citric Acid, usp, Anhydrous Powder 2 amount part and mogroside 0.9 weight part.
2, the operation identical with embodiment 1 preparation process is adopted to prepare the protective foods (product 4) of yin-deficiency constitution. Embodiment 5: the protective foods (five) of yin-deficiency constitution
1, crude drug raw material composition: sealwort 150 weight part, radix polygonati officinalis 35 weight part, mulberry fruit 54 weight part, lotus seeds 64 weight part, Flos Chrysanthemi 32 weight part, Chinese yam 36 weight part;
Make the composition after extract: Rhizoma Polygonati extract 30 weight part, Rhizoma Polygonati Odorati extract 10 weight part, Fructus Mori extract 12 weight part, Semen Nelumbinis extract 8 weight part, Flos Chrysanthemi extract 8 weight part, Rhizoma Dioscoreae extract 6 weight part;
Auxiliary material: maltodextrin 50 weight part, xanthan gum 1.5 weight part, Citric Acid, usp, Anhydrous Powder 1 weight part and mogroside 1 weight part.
2, the operation identical with embodiment 1 preparation process is adopted to prepare the protective foods (product 5) of yin-deficiency constitution. Embodiment 6: the protective foods (six) of yin-deficiency constitution
1, crude drug raw material composition: sealwort 175 weight part, radix polygonati officinalis 38.5 weight part, mulberry fruit 54 weight part, lotus seeds 48 weight part, Flos Chrysanthemi 40 weight part, Chinese yam 42 weight part;
Make the composition after extract: Rhizoma Polygonati extract 35 weight part, Rhizoma Polygonati Odorati extract 11 weight part, Fructus Mori extract 12 weight part, Semen Nelumbinis extract 6 weight part, Flos Chrysanthemi extract 10 weight part, Rhizoma Dioscoreae extract 7 weight part;
Auxiliary material: maltodextrin 30 weight part, xanthan gum 1.3 amount part, Citric Acid, usp, Anhydrous Powder 1.1 weight part and mogroside 0.9 weight part.
2, the operation identical with embodiment 1 preparation process is adopted to prepare the protective foods (product 6) of yin-deficiency constitution. Experimental example 1 deficiency of Yin product assists the experiment research improving deficiency of Yin rat
One, experimental principle
Yin deficiency syndrome is clinical common basic card type. Root according to the literature, adopts thyroxine to merge the pathological model of the serpentine making rat deficiency of Yin, evaluates, by test body temperature, the effect improving deficiency of Yin rat medicine.
Two, test materials:
Product 1-3 prepared by trial-product: embodiment 1-3, buff powder.
Positive control: LIUWEI DIHUANG WAN, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory, the accurate word Z19993068 of traditional Chinese medicines, lot identification mark: 12077307. Female's bodyguard oral liquid, unlimited pole (China) company limited, lot number: 11H01A01.
Laboratory animal: Wistar rat purchases white Beijing Wei Tonglihua company limited, conformity certification number: SCXK (capital) 2007-0001 is male. Raise in China Medical Sciences Academy Medical Plants Institute SPF level animal room, animal room temperature 20��26 DEG C, relative humidity 40��70%.
Three, test method:
Wistar rat 70, it is divided into 7 groups at random, be respectively normal control, yin-deficient model comparison, low middle high three the dosage groups of product 1 (202.5,405,810mg/kg, be equivalent to 2.5,5,10 times of people consumption 4.86g/60kg respectively), product 2 (810mg/kg, be equivalent to 10 times of people consumption 4.86g/60kg), product 3 (810mg/kg, be equivalent to 10 times of people consumption 4.86g/60kg) and LIUWEI DIHUANG WAN comparison (3.6g/kg), female's bodyguard oral liquid (2.5ml/kg), each group gavage gives surrounding. In gastric infusion 20 days, equal gavage thyroxine (7.5mg/ is only)+serpentine (0.05mg/ is only) except Normal group, every day 1 time, continuous 10 times.
Four, statistical method
Measurement data data mean value �� standard is missed (mean �� standarderror) and is represented, each group difference compares employing t inspection, completes by EXCEL statistical software. P < 0.05 is that there were significant differences, and p < 0.01 is for there being pole significant difference.
Five, test-results:
Product 1-3 is on the impact of deficiency of Yin rat temperature: after rat deficiency of Yin modeling, compare with rats in normal control group, and model group rats body temperature increases. Comparing with model control group, product 1 high dose group, product 2 and product 3 obviously improve (p < 0.05) as seen, refer to table 1.
Table 1 product 1-3 is on the impact of deficiency of Yin rat temperature
Compare with model control group,*P < 0.05, has significant difference;**P < 0.01, has pole significant difference
Six, conclusion
Deficiency of Yin rat temperature is raised tool and improves significantly by product 1, product 2, product 3.
Experimental example 2 deficiency of Yin product assists the experiment research improving deficiency of Yin mouse
One, experimental principle:
Yin deficiency syndrome is clinical common basic card type. Root according to the literature, is adopted thyroxine to merge the pathological model of the serpentine making mouse deficiency of Yin, is evaluated the effect improving deficiency of Yin mouse medicine by anti-fatigue test.
Two. experiment material:
Product 1-3 prepared by trial-product: embodiment 1-3.
Positive control: LIUWEI DIHUANG WAN, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory, the accurate word Z19993068 of traditional Chinese medicines, lot identification mark: 12077307. Female's bodyguard oral liquid, unlimited pole (China) company limited, lot number: 11H01A01.
Laboratory animal: ICR mouse purchases white Beijing Wei Tonglihua company limited, conformity certification number: SCXK (capital) 2007-0001 is female. Raise in China Medical Sciences Academy Medical Plants Institute SPF level animal room.
Instrument: swimming instrument.
Three. test method:
ICR mouse 90, it is divided into 9 groups at random, be respectively normal control, yin-deficient model comparison, low middle high three the dosage groups of product 1 (405,810,1620mg/kg, be equivalent to 5,10,20 times of people consumption 4.86g/60kg respectively), product 2 (810mg/kg, be equivalent to 10 times of people consumption 4.86g/60kg), product 3 (810mg/kg, be equivalent to 10 times of people consumption 4.86g/60kg) and LIUWEI DIHUANG WAN comparison (720mg/kg), female's bodyguard oral liquid (5ml/kg), each group gavage gives surrounding. In gastric infusion 20 days, equal gavage thyroxine (3mg/ is only)+serpentine (0.02mg/ is only) except Normal group, every day 1 time, continuous 10 times.
1. antifatigue effect: half an hour after last administration, loads the soldering tin wire of body weight 10% respectively by mouse tail, puts it in room temperature (25 DEG C) water, observes the survival time.
Four. statistical method
Measurement data data mean value �� standard is missed (mean �� standarderror) and is represented, each group difference compares employing t inspection, completes by EXCEL statistical software. P < 0.05 is that there were significant differences, and p < 0.01 is for there being pole significant difference.
Five. result:
1. product is on the impact of mice burden swimming time:
Compare with model group,*P < 0.05, has significant difference
Six, conclusion
Experimental data shows: each dosage group of product 1 and product 2, product 3 can improve the mice burden swimming time, has and improves the tired effect of yin deficient model muscle power.
Claims (10)
1. a yin-deficiency constitution protective foods, it is characterized in that, by the extract of medicine and food raw materials sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, Flos Chrysanthemi and Chinese yam be active drug component and allow in medicine and food use auxiliary added ingredients make, consist of with the crude drug raw material of each effective medicine-food two-purpose component of parts by weight: sealwort 150��250 parts, 45��67.5 parts, mulberry fruit, radix polygonati officinalis 28��52.5 parts, 40��80 parts, lotus seeds, Flos Chrysanthemi 32��40 parts and Chinese yam 30��48 parts.
2. protective foods as claimed in claim 1, it is characterised in that, the described crude drug raw material with each effective medicine-food two-purpose component of parts by weight consists of: sealwort 240 parts, 60 parts, mulberry fruit, radix polygonati officinalis 36 parts, 60 parts, lotus seeds, Flos Chrysanthemi 36 parts and and Chinese yam 36 parts.
3. protective foods as claimed in claim 1, it is characterized in that, the weight part composition and ratio of described active drug component is: Rhizoma Polygonati extract 20��60 parts, Fructus Mori extract 5��20 parts, Rhizoma Polygonati Odorati extract 5��20 parts, Semen Nelumbinis extract 2��15 parts, Flos Chrysanthemi extract 5��15 parts and Rhizoma Dioscoreae extract 3��12 parts.
4. protective foods according to claim 3, it is characterized in that, the weight part composition and ratio of described active drug component is: Rhizoma Polygonati extract 30��50 parts, Fructus Mori extract 10��15 parts, Rhizoma Polygonati Odorati extract 8��15 parts, Semen Nelumbinis extract 5��10 parts, Flos Chrysanthemi extract 8��10 parts and Rhizoma Dioscoreae extract 5��8 parts.
5. protective foods according to claim 4, it is characterized in that, the weight part composition and ratio of described active drug component is: Rhizoma Polygonati extract 48 parts, Fructus Mori extract 13.33 parts, Rhizoma Polygonati Odorati extract 10.29 parts, Semen Nelumbinis extract 7.5 parts, Flos Chrysanthemi extract 9 parts and Rhizoma Dioscoreae extract 6 parts.
6. protective foods according to the arbitrary item of claim 1-5, it is characterised in that, the extracting method of described each extract is as follows: sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, Flos Chrysanthemi and Chinese yam all use boil water extraction method to obtain extract.
7. protective foods according to the arbitrary item of claim 1-5, it is characterised in that, also containing auxiliary material in this protective foods, one or more being selected from maltodextrin, xanthan gum, Citric Acid, usp, Anhydrous Powder and mogroside.
8. protective foods according to claim 6, it is characterised in that, also containing auxiliary material in this protective foods, one or more being selected from maltodextrin, xanthan gum, Citric Acid, usp, Anhydrous Powder and mogroside.
9. the preparation method of protective foods described in a claim 7 or 8, it is characterised in that, the method comprises the following steps: described Citric Acid, usp, Anhydrous Powder and mogroside is added water respectively and makes slurry; Rhizoma Polygonati extract, Fructus Mori extract, Flos Chrysanthemi extract, Rhizoma Polygonati Odorati extract, Semen Nelumbinis extract, Rhizoma Dioscoreae extract, xanthan gum, maltodextrin are dropped in nodulizer successively and mixes; treat that inlet temperature rises to 55��85 DEG C; regulate the whitewashing of peristaltic pump rotating speed; the mogroside slurry made, citric acid slurry are successively sprayed in boiling granulating machine; rising granulation; sieve, filling, to obtain final product.
10. application in preparation yin-deficiency constitution protective foods and medicine of protective foods described in the arbitrary item of claim 1-8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410182009.9A CN103948029B (en) | 2014-04-30 | 2014-04-30 | A kind of yin-deficiency constitution protective foods and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410182009.9A CN103948029B (en) | 2014-04-30 | 2014-04-30 | A kind of yin-deficiency constitution protective foods and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103948029A CN103948029A (en) | 2014-07-30 |
| CN103948029B true CN103948029B (en) | 2016-06-01 |
Family
ID=51325498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410182009.9A Active CN103948029B (en) | 2014-04-30 | 2014-04-30 | A kind of yin-deficiency constitution protective foods and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103948029B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375807A (en) * | 2017-08-01 | 2017-11-24 | 湖南橘色科技有限责任公司 | Yin-nourishing and health composition and preparation method |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236828A (en) * | 2016-10-31 | 2016-12-21 | 无限极（中国）有限公司 | Leaf of Cyclocarya paliurus Iljinskaja or the new application of its extract and Chinese medicine composition |
| CN108113012A (en) * | 2016-11-29 | 2018-06-05 | 烟台宝备生物技术有限公司 | A kind of yin-deficiency constitution food formula |
| CN106579438B (en) * | 2016-12-16 | 2020-06-19 | 国珍健康科技（北京）有限公司 | A granule preparation with refreshing effect |
| CN109105819A (en) * | 2018-09-03 | 2019-01-01 | 圣原健康产业有限公司 | Enriching yin invigorating the spleen composition and its preparation method and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102550757A (en) * | 2011-12-29 | 2012-07-11 | 郑州瑞龙制药股份有限公司 | Health-care tea |
| CN103599389A (en) * | 2013-11-08 | 2014-02-26 | 黄运同 | Medicine for treating senile xerostomia |
| CN103621989A (en) * | 2012-08-28 | 2014-03-12 | 浙江劲膳美生物科技有限公司 | Dietary meal or meal replacement product for yin deficiency physique |
| CN102586064B (en) * | 2012-02-28 | 2014-11-05 | 张新华 | Nutrition wine for nourishing yin and invigorating kidney |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100881917B1 (en) * | 2007-05-08 | 2009-02-04 | 박주환 | Noodle including functional material and manufacturing method thereof |
-
2014
- 2014-04-30 CN CN201410182009.9A patent/CN103948029B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102550757A (en) * | 2011-12-29 | 2012-07-11 | 郑州瑞龙制药股份有限公司 | Health-care tea |
| CN102586064B (en) * | 2012-02-28 | 2014-11-05 | 张新华 | Nutrition wine for nourishing yin and invigorating kidney |
| CN103621989A (en) * | 2012-08-28 | 2014-03-12 | 浙江劲膳美生物科技有限公司 | Dietary meal or meal replacement product for yin deficiency physique |
| CN103599389A (en) * | 2013-11-08 | 2014-02-26 | 黄运同 | Medicine for treating senile xerostomia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375807A (en) * | 2017-08-01 | 2017-11-24 | 湖南橘色科技有限责任公司 | Yin-nourishing and health composition and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103948029A (en) | 2014-07-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102160573B (en) | Milk shake for replacing meal and preparation method thereof | |
| CN103877263B (en) | A kind of antifatigue health preparation of the compound Chinese medicine such as red ginseng, maca, green-tea extract (theanine) | |
| CN103948029B (en) | A kind of yin-deficiency constitution protective foods and its preparation method | |
| CN103948031B (en) | A kind of deficiency of yang physique health food and preparation method thereof | |
| CN107952040A (en) | For nursing one's health the Chinese herbal ointment formula and its processing method of obstruction of the circulation of vital energy constitution | |
| CN102293927B (en) | Compound Chinese medicinal preparation with antifatigue and antioxidation effects, and preparation method thereof | |
| CN105010669A (en) | Refreshing and moistening health-care jasmine flower tea and production method thereof | |
| CN1408397A (en) | Composition containing melatonin and galangal fruit traditional Chinese medicine | |
| CN103155985B (en) | Rhizoma polygonati nutrition powder and preparation method thereof | |
| CN103349121B (en) | Hyperglycemia-hyperlipidemia-hypertension relieving health protection tea and preparation method thereof | |
| CN108355088A (en) | A kind of spina date seed medicinal liquor and preparation method thereof improving sleep quality | |
| CN106036894B (en) | A kind of food compositions for improving chemotherapy symptom and preparation method thereof | |
| CN102698099A (en) | Pill for treating diabetes mellitus | |
| CN101623365B (en) | Tuckahoe spleen-strengthening granules and preparation method thereof | |
| CN105853505A (en) | Qi-and-lung-tonifying healthcare medicine composition containing five-leaf gynostemma herb | |
| CN105770705A (en) | Medicinal preparation for treating functional dyspepsia of children and application of medicinal preparation | |
| CN111840465A (en) | Traditional Chinese medicine compound composition containing rhizoma polygonati, ginseng and dendrobium officinale leaves as well as preparation method, preparation and application of compound composition | |
| CN101164603A (en) | Compound concentrating matrimony vine capsule and preparation method thereof | |
| CN101342313A (en) | Health care granular formulation, preparation and application thereof | |
| CN106177476A (en) | A kind of Hyperglycemic health care compositions comprising Herba Dendrobii and Pericarpium Citri Reticulatae | |
| CN103637272B (en) | The lotus nut starch that a kind of applicable autumn and winter nourish | |
| CN104000180A (en) | Ginseng compound assisting in blood sugar level regulation and preparing method and application thereof | |
| CN102631487B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN102631486B (en) | Health care composition | |
| CN107362301A (en) | Fragrant Siberian cocklebur appetizing particle |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20171226 Address after: 102206 Beijing city Changping District Science Park Road 10 Huilongguan Hospital No. 1 building 4 layer Patentee after: Guozhen Health Science and Technology (Beijing) Co., Ltd. Address before: 100101 Beijing city Chaoyang District Anxiang Lane No. 11 building B block 18 layer Co-patentee before: Yantai new era Health Industry Co., Ltd. Patentee before: New Age Health Industry(Group) Co., Ltd. |
|
| TR01 | Transfer of patent right |