CN103948029A - Healthcare food with yin-deficiency constitution and preparation method thereof - Google Patents
Healthcare food with yin-deficiency constitution and preparation method thereof Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to a healthcare food with yin-deficiency constitution and a preparation method thereof. The healthcare food is prepared from medicinal and edible raw materials, namely rhizoma polygonati, mulberry, radix polygonati officinalis, lotus seed, chrysanthemum morifolium ramat and Chinese yam as effective drug components and allowed auxiliary adding ingredients in drug and food. Each effective medicinal and edible dual-purpose component comprises the following raw materials in parts by weight: 100-300 parts of rhizoma polygonati, 22.5-90 parts of mulberry, 17.5-70 parts of radix polygonati officinalis, 16-120 parts of lotus seed, 20-60 parts of chrysanthemum morifolium ramat and 18-72 parts of Chinese yam. The healthcare food has the effects of nourishing the liver and kidneys, producing saliva and moistening dryness, and regulating the spleen and the stomach aiming at people with yin-deficiency constitution.
Description
Technical field
The present invention relates to a kind of integration of drinking and medicinal herbs health food and preparation method thereof, be specifically related to for deficiency of Yin physique health food and preparation method thereof.
Background technology
Physique is formed by obtaining congenital heredity and the day after tomorrow, and individuality intrinsic, metastable characteristic aspect morphosis and functional activity, has correlation with psychological personality.Individual physique is different, shows as the reaction that stimulates to external world under physiological status and some otherness in adaptability, and the tendentiousness to the neurological susceptibility of some virulence factor and disease progression in pathogenic process.
Tcm constitution Theoretic Source About in < < through > >, in < < in > > to the somatotype of the formation of the constitutive character of individuality and different groups, physique, physique and with the relation of disease development, the problems such as control of disease all have detailed elaboration.The body and the spirit of tcm constitution theory forms opinion and thinks, physique is the synthesis of specific body quality and certain psychological quality, has embodied " unity of body and soul " thought of the traditional Chinese medical science.
Traditional Chinese Medicine Constitution Classification is to take human life activity's material base one yin, yang, gas, blood, body fluid prosperity and decline state as according to establishing, just because of in body, the prosperity and decline state of yin, yang, gas, blood, body fluid is different, thereby show as the physique otherness between individuality.
The understanding of the traditional Chinese medical science to deficiency of Yin physique, starts from < < through > >.Because the cloudy liquid such as body fluid essence and blood in body lose less, with yin asthenia generating intrinsic heat etc., show as the constitution status of principal character.The deficiency of Yin, refers to the YIN-fluid being insufficient such as essence, blood, seminal fluid of body.People's disposition of deficiency of Yin physique is more irritable, usually dysphoria.Show as body and become thin, flushed face, dryness of the mouth and throat, tired in the time of in the heart, feverishness in palms and soles, few dormancy, just dry, urine is yellow, not resistance to spring and summer, many cool drinks, thready rapid pulse, the red few tongue of tongue.If ill above-mentioned all diseases are more obvious, or with the few phlegm of dry cough, hectic fever night sweat (Lung-Yin deficiency); Or palpitation and amnesia, insomnia and dreamful sleep (deficiency of the heart-yin); Or have a pain in the back, dizzy tinnitus, man's seminal emission, woman's Hypomenorrhea (kidney-yin deficiency); Or hypochondriac pain, blurring of vision (deficiency of the liver-yin).The main subhealth symptom of deficiency of Yin physique is summed up the Three Character Primer: deficiency of Yin matter, olighydria, five heart heat, dry mouth and throat.
At present, for improving deficiency of Yin physique symptom, have nourishing liver and kidneyly, promote the production of body fluid and moisturize, function of spleen and stomach regulating effect be all some Chinese medicines, mouthfeel is poor, takes inconvenience.
Summary of the invention
For the problems referred to above of prior art, the invention provides a kind ofly for deficiency of Yin physique, have nourishing liver and kidneyly, promote the production of body fluid and moisturize, health food of function of spleen and stomach regulating effect and preparation method thereof.
For achieving the above object, the present invention includes following technical scheme:
A kind of deficiency of Yin physique health food, it is to take the extract of medicine and food raw materials sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, FLOS CHRYSANTHEMI ALBA from Haizhou of China and Chinese yam to be active drug component and in medicine and food, to allow the auxiliary adding ingredient using to form, and in the crude drug raw material of each effective medicine-food two-purpose component of weight portion, consists of: 18～72 parts of 100～300 parts of sealworts, 22.5～90 parts, mulberry fruit, 17.5～70 parts of radix polygonati officinalis, 16～120 parts, lotus seeds, 20～60 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China and Chinese yams.
Health food as above, preferably, the crude drug raw material of described each effective medicine-food two-purpose component in weight portion consists of: 30～48 parts of 150～250 parts of sealworts, 45～67.5 parts, mulberry fruit, 28～52.5 parts of radix polygonati officinalis, 40～80 parts, lotus seeds, 32～40 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China and Chinese yams.
Health food as above, preferably, the crude drug raw material of described each effective medicine-food two-purpose component in weight portion consists of: 240 parts of sealworts, 60 parts, mulberry fruit, 36 parts of radix polygonati officinalis, 60 parts, lotus seeds, 36 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China and and 36 parts of Chinese yams.
Health food as above, preferably, the weight portion composition and ratio of described active drug component is: 3～12 parts of 20～60 parts of Rhizoma Polygonati extracts, 5～20 parts of Fructus Mori extracts, 5～20 parts of Rhizoma Polygonati Odorati extracts, 2～15 parts of Semen Nelumbinis extracts, 5～15 parts of Flos Chrysanthemi extracts and yam extracts.
Health food as above, preferably, the weight portion composition and ratio of described active drug component is: 5～8 parts of 30～50 parts of Rhizoma Polygonati extracts, 10～15 parts of Fructus Mori extracts, 8～15 parts of Rhizoma Polygonati Odorati extracts, 5～10 parts of Semen Nelumbinis extracts, 8～10 parts of Flos Chrysanthemi extracts and yam extracts.
Health food as above, preferably, the weight portion composition and ratio of described active drug component is: 6 parts of 48 parts of Rhizoma Polygonati extracts, 13.33 parts of Fructus Mori extracts, 10.29 parts of Rhizoma Polygonati Odorati extracts, 7.5 parts of Semen Nelumbinis extracts, 9 parts of Flos Chrysanthemi extracts and yam extracts.
Health food as above, preferably, the extracting method of described each extract is as follows: sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, FLOS CHRYSANTHEMI ALBA from Haizhou of China and Chinese yam are all used boil water extraction method to obtain extract.
Health food as above, preferably, also contains auxiliary material in this health food, select one or more in white maltodextrin, xanthans, anhydrous citric acid and mogroside.
Health food as above, preferably, the preparation method of described Rhizoma Polygonati extract is as follows:
Sealwort medicine materical crude slice, adds 4-10 times of water gaging and boils extraction 0.5-2 hour, extracts 1-3 time, and extracting liquid filtering, merges filtered fluid standby; Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; After centrifugate adds the 5-15% maltodextrin of output to mix, to spray dryer, be dried, spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain Rhizoma Polygonati extract.
Health food as above, preferably, the preparation method of described Fructus Mori extract is as follows:
Mulberries medicine materical crude slice, adds 4-10 times of water gaging and boils extraction 0.5-2 hour, extracts 1-3 time, and extracting liquid filtering, merges filtered fluid standby; Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; After centrifugate adds the 30-35% maltodextrin of output to mix, to spray dryer, be dried, spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain mulberries extract.
Health food as above, preferably, the preparation method of described Rhizoma Polygonati Odorati extract is as follows:
Radix polygonati officinalis medicine materical crude slice, adds 4-10 times of water gaging and boils extraction 0.5-2 hour, extracts 1-3 time, and extracting liquid filtering, merges filtered fluid standby; Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; After centrifugate adds the 13-19% maltodextrin of output to mix, to spray dryer, be dried, spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain Rhizoma Polygonati Odorati extract.
Health food as above, preferably, the preparation method of described Semen Nelumbinis extract is as follows:
Lotus seeds medicine materical crude slice, adds 4-10 times of water gaging and boils extraction 0.5-2 hour, extracts 1-3 time, and extracting liquid filtering, merges filtered fluid standby; Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; After centrifugate adds the 30-35% maltodextrin of output to mix, to spray dryer, be dried, spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain Semen Nelumbinis extract.
Health food as above, preferably, the preparation method of described yam extract is as follows:
Chinese yam medicine materical crude slice, adds 4-10 times of water gaging and boils extraction 0.5-2 hour, extracts 1-3 time, merges extract, filters, and filtered fluid is standby; Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; Centrifugate spraying is dry, and spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain yam extract.
Health food as above, preferably, the preparation method of described Flos Chrysanthemi extract is as follows:
FLOS CHRYSANTHEMI ALBA from Haizhou of China, adds 4-10 times of water gaging and boils extraction 0.5-2 hour, extracts 1-3 time, merges extract, filters, and filtered fluid is standby; Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; Centrifugate spraying is dry, and spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain Flos Chrysanthemi extract.
Health food as above, preferably, in the health food of every 100 weight portions containing 0.5～2.0 part of 20～60 parts of maltodextrins, 0.5～2.5 part of xanthans, 0.5～2.5 part of anhydrous citric acid and mogroside.
Health food of the present invention, for deficiency of Yin physique crowd, when producing, can increase or reduce according to corresponding ratio, as large-scale production can be with a kilogram Huo Yidunwei unit, small-scale production also can be in grams, weight can increase or reduce, but each raw material weight proportioning constant rate between forming.
On the other hand, the invention provides the preparation method of health food as mentioned above, the method comprises the following steps: described anhydrous citric acid and mogroside are added to water and make slurry; Rhizoma Polygonati extract, Fructus Mori extract, Flos Chrysanthemi extract, Rhizoma Polygonati Odorati extract, Semen Nelumbinis extract, yam extract, xanthans, maltodextrin are dropped in granulator and mixed successively; treat that EAT rises to 55～85 ℃; regulate the whitewashing of peristaltic pump rotating speed; the Momordica grosvenori slurry of making, citric acid slurry are successively sprayed in fluid bed granulator; rising granulation; sieve, filling, obtain.
Again on the one hand, the invention provides the application of health food as above in preparation deficiency of Yin physique health food and medicine.
Application as above, preferably, the dosage of described health food is 3-15g/ days.
The present invention is directed to deficiency of Yin physique crowd, have nourishing liver and kidneyly, promote the production of body fluid and moisturize, the health food of function of spleen and stomach regulating effect, its beneficial effect is, formula Design adopts the frame structure of traditional Chinese medicine " monarch, minister, help, make ".Monarch drug in a prescription sealwort, the moon that can not only nourishing lung and kidney, and also can invigoration spleen qi spleen cloudy, there is the earth generating metal of benefit, mend the day after tomorrow to support congenital effect.And lung spleen kidney three is dirty is to be monarch drug in a prescription with mending.Radix polygonati officinalis, mulberry fruit, lotus seeds are minister, nourishing yin to moisten dryness, and cool blood enriching blood and promoting secretion of body fluid, can prevent and treat yin asthenia generating intrinsic heat.FLOS CHRYSANTHEMI ALBA from Haizhou of China is adjutant, asthenia yin causing endopyrexia, and less compatibility chrysanthemum can heat-clearing, prevents heat impairment of yin again.Stomach nourishing Chinese yam invigorating the spleen, the taste of anti-monarch-minister drug is greasy, for making medicine.All medicines share, not only mended congenital, but also mend the day after tomorrow, liver, stomach, lung are taken into account simultaneously, five is cloudy and mend.Play altogether nourishing liver and kidneyly, promote the production of body fluid and moisturize, the merit of function of spleen and stomach regulating.The main subhealth symptom of alleviating deficiency of Yin physique crowd, shows as dry mouth and throat, is hard and dry, and order is dry, and flushed face, warms sense, blurred vision, and dizzy tinnitus, To Be Protected from Heat, sleep poor, easy irritability etc.
Health food of the present invention carries out compatibility with medicine-food two-purpose food materials, nurses one's health the biased of human body constitution, and curative effect is reliable, has no side effect, and taste is acceptant,, containing any anticorrisive agent, synthetic dyestuff, compound essence, does not have good stability, and is easy to carry.
The specific embodiment
Primary raw material of the present invention is sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, FLOS CHRYSANTHEMI ALBA from Haizhou of China and Chinese yam.
Sealwort: return spleen, lung, kidney three warps, nourshing kidney profit spleen, boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.
Mulberry fruit: the thoughts of returning home, liver, kidney channel, sweet in flavor and cold in property, there is liver-kidney tonifying, the effect such as the ease constipation of promoting the production of body fluid, black invention order.
Radix polygonati officinalis: property is sweet, be slightly cold, attaches to the lung and stomach meridians, and nourishing yin to moisten dryness, promotes the production of body fluid to quench thirst.
Lotus seeds: return spleen, kidney, the heart channel of Hang-Shaoyin.Tonifying spleen antidiarrheal, the puckery essence of kidney-nourishing, mental-tranquilization.
FLOS CHRYSANTHEMI ALBA from Haizhou of China: sweet, bitter, be slightly cold, return lung, Liver Channel.Loose wind heat-clearing, flat liver item.
Chinese yam: sweet, flat.Return spleen, lung, kidney essense.Tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying.
Mogroside, in the present invention as low calorie sweetener.
In side, monarch drug in a prescription sealwort is sweet, flat, boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.Sealwort can not only nourishing lung and kidney the moon, and can invigoration spleen qi spleen cloudy, have the earth generating metal of benefit, mend the day after tomorrow to support congenital effect.And lung spleen kidney three is dirty is to be monarch drug in a prescription with mending.As < < Compendium of Materia Medica > > says it: " mending all void ... replenishing essence marrow ".Mulberry fruit is sweet, sour, cold, can nourishing yin and supplementing blood, promote the production of body fluid and moisturize, and can relax bowel, cool blood brings down a fever, for thirsty, yin asthenia generating intrinsic heat glycosuria patient and the dry person of constipation matter, especially suitable, as < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " kidney-nourishing is dirty and controlling nocturnal emission with astringent drugs takes black invention order for a long time." < < Bencao Jingshu > >: " and for cool blood enrich blood benefit the moon medicine ".The people of deficiency of Yin physique, sick this deficiency of Yin, impairment of yin dryness-transformation, traces sth. to its source for a long time, all due to edge Tianjin blood deficiency, treating dryness syndrome by moistening.Radix polygonati officinalis property is sweet, be slightly cold, and attaches to the lung and stomach meridians, and nourishing yin to moisten dryness, promotes the production of body fluid to quench thirst.The lotus seeds tonifying spleen that can clear away heart-fire, mental-tranquilization, radix polygonati officinalis, mulberry fruit, lotus seeds are minister, nourishing yin to moisten dryness, cool blood enriching blood and promoting secretion of body fluid, can prevent and treat yin asthenia generating intrinsic heat.FLOS CHRYSANTHEMI ALBA from Haizhou of China is adjutant, asthenia yin causing endopyrexia, and less compatibility chrysanthemum can heat-clearing, prevents heat impairment of yin again.The many tastes of enriching yin Chinese medicine are greasy, are easy to block up taste, affect ascending or descending movement of vital Qi, stomach nourishing Chinese yam invigorating the spleen, and the taste of anti-monarch-minister drug is greasy, for making medicine.
All medicines share, not only mended congenital, but also mend the day after tomorrow, liver, stomach, lung are taken into account simultaneously, five is cloudy and mend.Play altogether nourishing liver and kidneyly, promote the production of body fluid and moisturize, the merit of function of spleen and stomach regulating.The main subhealth symptom of alleviating deficiency of Yin physique crowd, shows as dry mouth and throat, is hard and dry, and order is dry, and flushed face, warms sense, blurred vision, and dizzy tinnitus, To Be Protected from Heat, sleep poor, easy irritability etc.(Liuwei Dihuang Wan is the substantially square of deficiency of Yin physique, six Dihuang Wans are only mended kidney,liver,spleen three the moon, this dietotherapy side kidney,liver,spleen, the heart, the cloudy also benefit of lung five, and there is no the injury of Liuwei Dihuang Wan long-term taking to stomach, edible gentle safety is nursed one's health deficiency of Yin physique crowd's sub-health state comprehensively.)
Six medicines share altogether to be played: nourishing liver and kidney, and promote the production of body fluid and moisturize, the merit of function of spleen and stomach regulating.
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.In following examples, source or the preparation method of the raw material that uses are as follows:
1, the preparation method of Rhizoma Polygonati extract
Sealwort medicine materical crude slice adds 8 times of water gagings and boils extraction 1.5 hours, extracting liquid filtering, and the dregs of a decoction add 6 times of water gagings and boil extraction 1 hour, and extracting liquid filtering merges filtered fluid standby.Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; After centrifugate adds 10% maltodextrin of output to mix, to spray dryer, be dried, spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain Rhizoma Polygonati extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract approximately 20 weight portions.
2, the preparation method of Fructus Mori extract
Mulberries medicine materical crude slice adds 8 times of water gagings and boils extraction 1.5 hours, extracting liquid filtering, and the dregs of a decoction add 6 times of water gagings and boil extraction 1 hour, and extracting liquid filtering merges filtered fluid standby.Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; After centrifugate adds 33% maltodextrin of output to mix, to spray dryer, be dried, spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain mulberries extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract approximately 22.2 weight portions.
3, the preparation method of Rhizoma Polygonati Odorati extract
Radix polygonati officinalis, adds 8 times of water gagings and boils extraction 1.5 hours, extracting liquid filtering, and the dregs of a decoction add 6 times of water gagings and boil extraction 1 hour, and extracting liquid filtering merges filtered fluid standby.Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; After centrifugate adds 16% maltodextrin of output to mix, to spray dryer, be dried, spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain Rhizoma Polygonati Odorati extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract approximately 28.6 weight portions.
4, the preparation method of Semen Nelumbinis extract
Lotus seeds medicine materical crude slice adds 8 times of water gagings and boils extraction 1.5 hours, extracting liquid filtering, and the dregs of a decoction add 6 times of water gagings and boil extraction 1 hour, and extracting liquid filtering merges filtered fluid standby.Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; After centrifugate adds 33% maltodextrin of output to mix, to spray dryer, be dried, spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain Semen Nelumbinis extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract approximately 12.5 weight portions.
5, the preparation method of yam extract
Chinese yam, adds 8 times of water gagings and boils extraction 1.5 hours, extracting liquid filtering, and the dregs of a decoction add 6 times of water gagings and boil extraction 1 hour, and extracting liquid filtering merges filtered fluid standby.Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; Centrifugate spraying is dry, and spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain yam extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain extract approximately 16.7 weight portions.
6, the preparation method of Flos Chrysanthemi extract
FLOS CHRYSANTHEMI ALBA from Haizhou of China, adds 6 times of water gagings and boils extraction 1.5 hours, extracting liquid filtering, and the dregs of a decoction add 6 times of water gagings and boil extraction 1 hour, and extracting liquid filtering merges filtered fluid standby; Filtered fluid is concentrated, is concentrated into proportion 1.06-1.14; Concentrate is centrifugal with centrifuge, and extracting centrifugal liquid is standby; Centrifugate spraying is dry, and spray dryer EAT is 180-205 ℃, and leaving air temp is 90-105 ℃; Get the dry gained dried cream powder of spraying broken, cross 80 mesh sieves, obtain Flos Chrysanthemi extract.Through above-mentioned steps, every 100 weight portion crude drug raw materials obtain Flos Chrysanthemi extract approximately 25 weight portions.
7, mogroside is commercial, buys white Ningbo Liwah Plant Extract Technology Co., Ltd., lot number 20131001.
Embodiment 1: the health food of deficiency of Yin physique ()
1, crude drug raw material forms: sealwort 240 weight portions, radix polygonati officinalis 36 weight portions, mulberry fruit 60 weight portions, lotus seeds 60 weight portions, FLOS CHRYSANTHEMI ALBA from Haizhou of China 36 weight portions, Chinese yam 36 weight portions;
Make the composition after extract: Rhizoma Polygonati extract 48 weight portions, Rhizoma Polygonati Odorati extract 10.29 weight portions, Fructus Mori extract 13.33 weight portions, Semen Nelumbinis extract 7.5 weight portions, Flos Chrysanthemi extract 9 weight portions, yam extract 6 weight portions;
Auxiliary material: maltodextrin 51.99 weight portions, xanthans 1.5 weight portions, anhydrous citric acid 1.5 weight portions and mogroside 0.9 weight portion.
2, preparation process:
1) weigh: total inventory 150kg, according to formula ratio, weigh, standby.
2) sieve: xanthans is crossed 80 mesh sieves, standby.
3) slurrying: by the citric acid of formula ratio and mogroside, be dissolved in the water of prescription gross weight 15%, standby.
4) boiling granulating: Rhizoma Polygonati extract, Fructus Mori extract, Rhizoma Polygonati Odorati extract, Semen Nelumbinis extract, Flos Chrysanthemi extract, yam extract, xanthans, maltodextrin are dropped in granulator successively.First blow and mix for 10 minutes, treat that EAT rises to 76 ℃, be adjusted to peristaltic pump rotating speed, Momordica grosvenori slurry and citric acid slurry that step 3 is made spray in fluid bed granulator, rising granulation, and material moisture is less than 4% discharging.
5) sieve: 20 order vibratory sieves.
6) filling (inner packing): with 10 row machines, carry out fillingly, 5g/ bag, obtains product 1.
Embodiment 2: the health food of deficiency of Yin physique (two)
1, crude drug raw material forms: sealwort 200 weight portions, radix polygonati officinalis 70 weight portions, mulberry fruit 22.5 weight portions, lotus seeds 120 weight portions, FLOS CHRYSANTHEMI ALBA from Haizhou of China 60 weight portions, Chinese yam 72 weight portions;
Make the composition after extract: Rhizoma Polygonati extract 40 weight portions, Rhizoma Polygonati Odorati extract 20 weight portions, Fructus Mori extract 5 weight portions, Semen Nelumbinis extract 15 weight portions, Flos Chrysanthemi extract 15 weight portions, yam extract 12 weight portions;
Auxiliary material: maltodextrin 60 weight portions, xanthans 2.5 weight portions, anhydrous citric acid 2.5 weight portions and mogroside 1.8 weight portions.
2, the health food (product 2) of deficiency of Yin physique is prepared in the employing operation identical with embodiment 1 preparation process.
Embodiment 3: the health food of deficiency of Yin physique (three)
1, crude drug raw material forms: sealwort 150 weight portions, radix polygonati officinalis 17.5 weight portions, mulberry fruit 45 weight portions, lotus seeds 40 weight portions, FLOS CHRYSANTHEMI ALBA from Haizhou of China 32 weight portions, Chinese yam 30 weight portions;
Make the composition after extract: Rhizoma Polygonati extract 30 weight portions, Rhizoma Polygonati Odorati extract 5 weight portions, Fructus Mori extract 10 weight portions, Semen Nelumbinis extract 5 weight portions, Flos Chrysanthemi extract 8 weight portions, yam extract 5 weight portions;
Auxiliary material: maltodextrin 25 weight portions, xanthans 0.6 weight portion, anhydrous citric acid 0.5 weight portion and mogroside 0.6 weight portion.
2, the health food (product 3) of deficiency of Yin physique is prepared in the employing operation identical with embodiment 1 preparation process.Embodiment 4: the health food of deficiency of Yin physique (four)
1, crude drug raw material forms: sealwort 225 weight portions, radix polygonati officinalis 52.5 weight portions, mulberry fruit 67.5 weight portions, lotus seeds 80 weight portions, FLOS CHRYSANTHEMI ALBA from Haizhou of China 40 weight portions, Chinese yam 48 weight portions;
Make the composition after extract: Rhizoma Polygonati extract 45 weight portions, Rhizoma Polygonati Odorati extract 15 weight portions, Fructus Mori extract 15 weight portions, Semen Nelumbinis extract 10 weight portions, Flos Chrysanthemi extract 10 weight portions, yam extract 8 weight portions;
Auxiliary material: maltodextrin 55 weight portions, xanthans 2 weight portions, anhydrous citric acid 2 amounts part and mogroside 0.9 weight portions.
2, the health food (product 4) of deficiency of Yin physique is prepared in the employing operation identical with embodiment 1 preparation process.Embodiment 5: the health food of deficiency of Yin physique (five)
1, crude drug raw material forms: sealwort 150 weight portions, radix polygonati officinalis 35 weight portions, mulberry fruit 54 weight portions, lotus seeds 64 weight portions, FLOS CHRYSANTHEMI ALBA from Haizhou of China 32 weight portions, Chinese yam 36 weight portions;
Make the composition after extract: Rhizoma Polygonati extract 30 weight portions, Rhizoma Polygonati Odorati extract 10 weight portions, Fructus Mori extract 12 weight portions, Semen Nelumbinis extract 8 weight portions, Flos Chrysanthemi extract 8 weight portions, yam extract 6 weight portions;
Auxiliary material: maltodextrin 50 weight portions, xanthans 1.5 weight portions, anhydrous citric acid 1 weight portion and mogroside 1 weight portion.
2, the health food (product 5) of deficiency of Yin physique is prepared in the employing operation identical with embodiment 1 preparation process.Embodiment 6: the health food of deficiency of Yin physique (six)
1, crude drug raw material forms: sealwort 175 weight portions, radix polygonati officinalis 38.5 weight portions, mulberry fruit 54 weight portions, lotus seeds 48 weight portions, FLOS CHRYSANTHEMI ALBA from Haizhou of China 40 weight portions, Chinese yam 42 weight portions;
Make the composition after extract: Rhizoma Polygonati extract 35 weight portions, Rhizoma Polygonati Odorati extract 11 weight portions, Fructus Mori extract 12 weight portions, Semen Nelumbinis extract 6 weight portions, Flos Chrysanthemi extract 10 weight portions, yam extract 7 weight portions;
Auxiliary material: maltodextrin 30 weight portions, xanthans 1.3 amounts parts, anhydrous citric acid 1.1 weight portions and mogroside 0.9 weight portion.
2, the health food (product 6) of deficiency of Yin physique is prepared in the employing operation identical with embodiment 1 preparation process.The auxiliary experimental study that improves deficiency of Yin rat of experimental example 1 deficiency of Yin product
One, experimental principle
Yin deficiency syndrome is common clinically basic card type.According to bibliographical information, adopt thyroxine to merge the pathological model that reserpine is made the rat deficiency of Yin, by test body temperature, evaluate the effect that improves deficiency of Yin rat medicine.
Two, test material:
Test sample: product 1-3 prepared by embodiment 1-3, buff powder.
Positive control: Liuwei Dihuang Wan, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory, the accurate word Z19993068 of traditional Chinese medicines, batch number: 12077307.Female's bodyguard oral liquid, the unlimited utmost point (China) Co., Ltd, lot number: 11H01A01.
Animal used as test: Wistar rat is purchased white Beijing and ties up tonneau China Co., Ltd, the quality certification number: SCXK (capital) 2007-0001 is male.Raise in the SPF of China Medical Sciences Academy Medical Plants Institute level Animal House, 20～26 ℃ of Animal House temperature, relative humidity 40～70%.
Three, test method:
70 of Wistar rats, be divided at random 7 groups, be respectively the contrast of normal control, deficiency of Yin model, the low middle Senior Three of a product 1 dosage group (202.5,405,810mg/kg, be equivalent to respectively 2.5,5,10 times of people's consumption 4.86g/60kg), product 2 (810mg/kg, be equivalent to 10 times of people's consumption 4.86g/60kg), product 3 (810mg/kg, be equivalent to 10 times of people's consumption 4.86g/60kg) and Liuwei Dihuang Wan contrast (3.6g/kg), female's bodyguard oral liquid (2.5ml/kg), each is organized gavage and gives surrounding.In gastric infusion 20 days, equal gavage thyroxine except Normal group (7.5mg/ is only)+reserpine (0.05mg/ is only), every day 1 time, continuous 10 times.
Four, statistical method
Measurement data is mean value ± standard error (mean ± standard error) expression for data, and each group difference relatively adopts t check, by EXCEL statistical software, is completed.P<0.05 is that there were significant differences, and p<0.01 is for there being utmost point significant difference.
Five, result of the test:
The impact of product 1-3 on deficiency of Yin rat temperature: after the modeling of the rat deficiency of Yin, with rats in normal control group comparison, model group rat temperature increases.With model control group comparison, product 1 high dose group, product 2 and product 3 obviously improve (p<0.05) as seen, refer to table 1.
The impact of table 1 product 1-3 on deficiency of Yin rat temperature
With model control group comparison,
*p<0.05, has significant difference;
*p<0.01, has utmost point significant difference
Six, conclusion
Product 1, product 2,3 pairs of deficiency of Yin rat temperature rising tools of product improve significantly.
The auxiliary experimental study that improves deficiency of Yin mouse of experimental example 2 deficiency of Yin products
One, experimental principle:
Yin deficiency syndrome is common clinically basic card type.According to bibliographical information, adopt thyroxine to merge the pathological model that reserpine is made the mouse deficiency of Yin, by anti-fatigue test evaluation, improve the effect of deficiency of Yin mouse medicine.
Two. experiment material:
Test sample: product 1-3 prepared by embodiment 1-3.
Positive control: Liuwei Dihuang Wan, Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory, the accurate word Z19993068 of traditional Chinese medicines, batch number: 12077307.Female's bodyguard oral liquid, the unlimited utmost point (China) Co., Ltd, lot number: 11H01A01.
Animal used as test: ICR mouse is purchased white Beijing and ties up tonneau China Co., Ltd, the quality certification number: SCXK (capital) 2007-0001 is female.Raise in the SPF of China Medical Sciences Academy Medical Plants Institute level Animal House.
Instrument: swimming instrument.
Three. test method:
90 of ICR mouse, be divided at random 9 groups, be respectively the contrast of normal control, deficiency of Yin model, the low middle Senior Three of a product 1 dosage group (405,810,1620mg/kg, be equivalent to respectively 5,10,20 times of people's consumption 4.86g/60kg), product 2 (810mg/kg, be equivalent to 10 times of people's consumption 4.86g/60kg), product 3 (810mg/kg, be equivalent to 10 times of people's consumption 4.86g/60kg) and Liuwei Dihuang Wan contrast (720mg/kg), female's bodyguard oral liquid (5ml/kg), each is organized gavage and gives surrounding.In gastric infusion 20 days, equal gavage thyroxine except Normal group (3mg/ is only)+reserpine (0.02mg/ is only), every day 1 time, continuous 10 times.
1. antifatigue effect: half an hour after last administration, mouse tail is loaded respectively to the solder stick of body weight 10%, put it in room temperature (25 ℃) water, observe the time-to-live.
Four. statistical method
Measurement data is mean value ± standard error (mean ± standard error) expression for data, and each group difference relatively adopts t check, by EXCEL statistical software, is completed.P<0.05 is that there were significant differences, and p<0.01 is for there being utmost point significant difference.
Five. result:
1. the impact of product on the mice burden swimming time:
With model group comparison,
*p<0.05, has significant difference
Six, conclusion
Experimental data shows: product 1 each dosage group and product 2, product 3 can improve the mice burden swimming time, have the effect of improving yin deficient model physical fatigue.
Claims (10)
1. a deficiency of Yin physique health food, it is characterized in that, the extract of medicine and food raw materials sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, FLOS CHRYSANTHEMI ALBA from Haizhou of China and Chinese yam of take is active drug component and in medicine and food, allows the auxiliary adding ingredient using to form, and in the crude drug raw material of each effective medicine-food two-purpose component of weight portion, consists of: 18～72 parts of 100～300 parts of sealworts, 22.5～90 parts, mulberry fruit, 17.5～70 parts of radix polygonati officinalis, 16～120 parts, lotus seeds, 20～60 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China and Chinese yams.
2. health food as claimed in claim 1, it is characterized in that, the crude drug raw material of described each effective medicine-food two-purpose component in weight portion consists of: 30～48 parts of 150～250 parts of sealworts, 45～67.5 parts, mulberry fruit, 28～52.5 parts of radix polygonati officinalis, 40～80 parts, lotus seeds, 32～40 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China and Chinese yams.
3. health food as claimed in claim 1, is characterized in that, the crude drug raw material of described each effective medicine-food two-purpose component in weight portion consists of: 240 parts of sealworts, 60 parts, mulberry fruit, 36 parts of radix polygonati officinalis, 60 parts, lotus seeds, 36 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China and and 36 parts of Chinese yams.
4. health food as claimed in claim 1, it is characterized in that, the weight portion composition and ratio of described active drug component is: 3～12 parts of 20～60 parts of Rhizoma Polygonati extracts, 5～20 parts of Fructus Mori extracts, 5～20 parts of Rhizoma Polygonati Odorati extracts, 2～15 parts of Semen Nelumbinis extracts, 5～15 parts of Flos Chrysanthemi extracts and yam extracts.
5. health food according to claim 4, it is characterized in that, the weight portion composition and ratio of described active drug component is: 5～8 parts of 30～50 parts of Rhizoma Polygonati extracts, 10～15 parts of Fructus Mori extracts, 8～15 parts of Rhizoma Polygonati Odorati extracts, 5～10 parts of Semen Nelumbinis extracts, 8～10 parts of Flos Chrysanthemi extracts and yam extracts.
6. health food according to claim 5, it is characterized in that, the weight portion composition and ratio of described active drug component is: 6 parts of 48 parts of Rhizoma Polygonati extracts, 13.33 parts of Fructus Mori extracts, 10.29 parts of Rhizoma Polygonati Odorati extracts, 7.5 parts of Semen Nelumbinis extracts, 9 parts of Flos Chrysanthemi extracts and yam extracts.
7. according to the health food described in claim 1-6 any one, it is characterized in that, the extracting method of described each extract is as follows: sealwort, mulberry fruit, radix polygonati officinalis, lotus seeds, FLOS CHRYSANTHEMI ALBA from Haizhou of China and Chinese yam are all used boil water extraction method to obtain extract.
8. according to the health food described in claim 1-7 any one, it is characterized in that, in this health food, also contain auxiliary material, select one or more in white maltodextrin, xanthans, anhydrous citric acid and mogroside.
9. a preparation method for health food claimed in claim 8, is characterized in that, the method comprises the following steps: described anhydrous citric acid and mogroside are added to water and make slurry; Rhizoma Polygonati extract, Fructus Mori extract, Flos Chrysanthemi extract, Rhizoma Polygonati Odorati extract, Semen Nelumbinis extract, yam extract, xanthans, maltodextrin are dropped in granulator and mixed successively; treat that EAT rises to 55～85 ℃; regulate the whitewashing of peristaltic pump rotating speed; the Momordica grosvenori slurry of making, citric acid slurry are successively sprayed in fluid bed granulator; rising granulation; sieve, filling, obtain.
10. the application of the health food described in claim 1-8 any one in preparation deficiency of Yin physique health food and medicine.
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| CN109105819A (en) * | 2018-09-03 | 2019-01-01 | 圣原健康产业有限公司 | Enriching yin invigorating the spleen composition and its preparation method and application |
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| CN107375807A (en) * | 2017-08-01 | 2017-11-24 | 湖南橘色科技有限责任公司 | Yin-nourishing and health composition and preparation method |
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| CN108113012A (en) * | 2016-11-29 | 2018-06-05 | 烟台宝备生物技术有限公司 | A kind of yin-deficiency constitution food formula |
| CN106579438A (en) * | 2016-12-16 | 2017-04-26 | 新时代健康产业（集团）有限公司 | Granular preparation with refreshing effect |
| CN109105819A (en) * | 2018-09-03 | 2019-01-01 | 圣原健康产业有限公司 | Enriching yin invigorating the spleen composition and its preparation method and application |
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| CN103948029B (en) | 2016-06-01 |
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