CN100493578C - Chinese medicine composition for treating thin body and delicate constitution, and preparing method - Google Patents
Chinese medicine composition for treating thin body and delicate constitution, and preparing method Download PDFInfo
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- CN100493578C CN100493578C CNB2005100221024A CN200510022102A CN100493578C CN 100493578 C CN100493578 C CN 100493578C CN B2005100221024 A CNB2005100221024 A CN B2005100221024A CN 200510022102 A CN200510022102 A CN 200510022102A CN 100493578 C CN100493578 C CN 100493578C
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Abstract
The present invention provides a Chinese medicinal composition used for treating physical emaciation and weak constitution and a preparing method thereof, which relates to a medicinal composition, parThe invention is a Chinese drug combination for curing physique marasmus and weakness and the preparing method thereof, relating to a drug combination, especially relating to a drug with Chinese medicticularly to a medicine made by using plant traditional Chinese medicine as raw materials and a preparing method thereof. The medicinal composition is medicament prepared from the raw materials of theinal herbs as raw materials and the preparing method thereof, prepared of the following raw materials in weight shares: Spina Date Seed 3-6, Medicinal Changium Root 2.5-5, Largehead AtractylodesRhizom following proportion by weight: 3 to 6 shares of jujube seeds, 2.5 to 5 shares of codonopsis pilosula, 1 to 2 shares of atractylodes macrocephala, 1.5 to 2.5 shares of tuckahoe, 1.5 to 2.5 shares of e 1-2, Fuling 1.5-2.5, Coix Seed 1.5-2.5, Dried Tangerine Peel 1-2, Rice-grain Sprout 1.5-2.5, and Liquoricee Root 0.3-0.6 into capsules, soft capsules, pill drops, tablets or granules, and used to cusemen coicis, 1 to 2 shares of orange peel, 1.5 to 2.5 shares of rice sprouts and 0.3 to 0.6 share of liquorice. The medicine is made into capsules, soft capsules, dripping pills, tablets or particlesre physique marasmus and weakness for restoring human standard weight and improving the physique. . The medicine of the present invention is used for treating physical emaciation and weak constitution, and the present invention has the aim of restoring the standard weight of a human body and strengthening constitution.
Description
(1) technical field: the present invention is a kind of pharmaceutical composition, and especially relating to a kind of is the medicine that raw material is made with the botanical herbs.
(2) background technology: current " fat-reducing " is in vogue, and the fat-reducing medicine emerges in an endless stream.Yet, very important, still have many people (showing that according to the Shanghai statistics person of becoming thin accounts for crowd's 2%-3%) to seek medical advice and medicine both at home and abroad everywhere because of suffering from " becoming thin ".Marasmus can cause numerous disease, as visceroptosis (the wherein sagging urinary tract infection that causes again that repeatedly difficulty heals of kidney), deformity of spine, immunity degradation, female uterine prolapse, irregular menstruation, infertility or the like.As seen, the treatment of becoming thin can not be ignored, and control is become thin significant to improving China's population quality effectively.Ancient Times in China draws attention to becoming thin, beginning of " becoming thin " sees " emperor in through " (" bier is contrary along girth of a garment the 38 "), back ancient Chinese medicine doctor has argumentation to its cause of disease, the rule of treatment, especially more with the Tang Dynasty " Essential Recipes for Emergent Use Worth A Thousand Gold rolls up 12 " argumentation, nearly ten of the prescriptions that the record treatment is become thin.And the product of the most non-feed cream fat of the patient that becomes thin now very little due to, but weaken relevant with the transporting and transforming function of the spleen and stomach absorption function.According to theory of Chinese medical science, the spleen being the foundation of acquired constitution, source of generating QI and blood, the spleen controlling the muscles of whole body, temper is strong, and QI and blood biochemistry is active, and water is so precise and tiny part of rarefaction whole body moistens foster muscle, and it is rich sturdy to make us body.Deficiency-weakness of spleen-QI, letter fortune mistake department prolongs for a long time and does not more cause deficiency of spleen-QI, and fortuneization mistake is strong, and it is slow digest, and defeated cloth is precise and tiny weak, causes water and wets interior livingly, and temper is instead by being stranded, the patient has more now " abdominal distension due to deficiency " so class is become thin; Deficiency of spleen-QI, gastric qi also a little less than, the function of becoming thoroughly decomposed dereliction of duty, so-called " eat and do not transport, its disease being located in the spleen ".The basic pathogenesis of as seen, becoming thin is deficiency of qi and blood due to deficiency-weakness of spleen-QI.Along with the development of society, change has all taken place in medical model, spectrum of disease.Clinical many chronic diseases, except that see become thin, how white with tired, poor appetite, complexion rolling, pale tongue, thready and weak pulse.As seen the intestinal bowel syndrome of doctor trained in Western medicine, chronic colitis, stomach, duodenal ulcer, chronic gastritis, anemia etc. all become thin.Because what a variety of causes caused becomes thin at clinical pilosity, and prevent and treat the medicine still few (look into and newly show according to Sichuan Province, city's medical science and technology information institute, do not see control marasmus medicine) of the aspect of becoming thin at present both at home and abroad.Domesticly do not see the Chinese patent medicine listing that has treatment to become thin, what have only is health product.Report Jiang Yi pool is arranged from intending the insufficiency of the spleen insufficiency of vital energy and blood of weight gaining benefit health pill for curing 120 examples of becoming thin, curative effect is better, but this product only reports for clinical experience, does not see this launch.Domestic more prescribed preparation is to be purpose with the air making-up and spleen enlivening, as decoction of four noble drugs, ginseng Siberian cocklebur Rhizoma Atractylodis Macrocephalae capsule, GUIPI WAN etc.
(3) summary of the invention: the present invention provides a kind of treatment bodily form to become thin at the problem of above-mentioned existence, has a delicate constitution, and is intended to recover the human body standard body weight, constitutional Chinese medicine preparation and preparation method thereof.Its technical scheme is:
Medicine of the present invention comprises following component: (consumption is a weight portion)
Semen Ziziphi Spinosae 3～6 Radix Codonopsis 2.5～5 Rhizoma Atractylodis Macrocephalaes 1～2 Poria 1.5～2.5
Semen Coicis 1.5～2.5 Pericarpium Citri Reticulataes 1～2 Fructus Setariae Germinatus 1.5～2.5 Radix Glycyrrhizaes 0.3～0.6
Weight (part) ratio range of the formula optimization of preparation medicine of the present invention is:
Semen Ziziphi Spinosae 4～5.5 Radix Codonopsis 3～4.5 Rhizoma Atractylodis Macrocephalaes 1.5～2 Poria 2～2.5
Semen Coicis 1.5～2 Pericarpium Citri Reticulataes 1.5～2 Fructus Setariae Germinatuss 1.5～2 Radix Glycyrrhizaes 0.4～0.5
The optimum weight of medicine of the present invention (part) proportioning is:
Semen Ziziphi Spinosae 4.5 Radix Codonopsis 4 Rhizoma Atractylodis Macrocephalaes 1.5 Poria 2
Semen Coicis 2 Pericarpium Citri Reticulataes 1.5 Fructus Setariae Germinatuss 2 Radix Glycyrrhizaes 0.5
Above-mentioned each component is made medicine production method of the present invention is:
Get Semen Ziziphi Spinosae, 60%～80% ethanol extraction of 4～6 times of amounts of adding 2～3 times, each time of extracting is 1～2 hour, filters merging filtrate; Get the Pericarpium Citri Reticulatae and the Rhizoma Atractylodis Macrocephalae, distillating extracting oil 3～12 hours was steeped in the water logging that adds 6～10 times of amounts 30～40 minutes; Volatile oil retains standby or with the clathrate of 4～8 times of amounts, 30～50 ℃ were stirred enclose 1～2 hour, 5～15 ℃ of cold preservations placements 10～12 hours, and sucking filtration, clathrate drying under reduced pressure under 0.04～0.07mpa, 30～40 ℃ of conditions is standby; Medicinal residues after the extraction and all the other medicines merge, and the decocting that adds 8～12 times of amounts boils 2～3 times, and each time that decocts is 1～2 hour, filters merging filtrate; Medicinal liquid and said extracted liquid merge, and are concentrated into the extractum of relative density 1.20～1.25, and drying is ground into fine powder, add volatile oil and adjuvant that volatile oil or enclose are crossed, select 70～90% alcohol granulation, incapsulate after the drying, or make drop pill, or be pressed into tablet, or make granule.Above-mentioned adjuvant can be selected any one or a few combination of starch, magnesium stearate, sucrose, dextrin, calcium carbonate, sodium carboxymethyl cellulose for use, and consumption is an extractum: adjuvant is 2～6:1～3.If several adjuvants are used in combination, the consumption of each adjuvant is different and different according to pharmaceutical dosage form, and each supplementary product consumption equalization generally speaking because of the usage and dosage of adjuvant is the usual manner method, repeats no more here.
Clinical drug of the present invention uses the result to show, its beneficial effect is: 1, product of the present invention is according to Clinical Experience, be on the SHENLING BAISHU SAN basis that traditional classical prescription " prescription of peaceful benevolent dispensary " records, to add and subtract to form, be that becoming thin due to the insufficiency of the spleen insufficiency of vital energy and blood of handed down from the older generations of the family control is effective proved recipe of primary symptom, for the vast patient of becoming thin removes misery, benefit society.2, product of the present invention is rich in effective ingredient such as triterpene saponin, flavonoid, aminoacid, volatile oil, trace element, starch, vitamin, organic acid, polysaccharide, according to clinical application experience and this product pharmacology, toxicological study result, show that this product has facilitating digestion and absorbs, promote appetite, physical strength reinforcing, promote glycogen synthetic, the effect of enhance immunity and hypnotic, function cures mainly to benefiting QI and nourishing blood, activating the spleen stomach function regulating, helps cloudy strong body.The clinical bodily form that is used for is become thin, is had a delicate constitution, and weak, anorexia, abdominal distention, loose stool, light red tongue, weak pulse belong to insufficiency of the spleen insufficiency of vital energy and blood person, becomes thin at the control spleen-deficient, recovers standard body weight aspect determined curative effect.3, low cost product of the present invention, instructions of taking is simple, convenient, is easy to be accepted by the vast patient of becoming thin, and has society and economical effects.
Solution of the present invention is based on the pharmacological properties of each raw material:
SHENLING BAISHU SAN is classical spleen benefiting and stimulating the appetite side, adds Semen Ziziphi Spinosae, Semen Coicis, Pericarpium Citri Reticulatae, Fructus Setariae Germinatus, has strengthened spleen benefiting and stimulating the appetite, nourishing blood function nourishes blood.Semen Ziziphi Spinosae is the dry mature seed of Rhamnaceae plant Ziziphi Spinosae Ziziphus ju jube Mill.Var.spinosa (Bunge) Hu ex H.F.Chou.The time of the year when autumn changes into winter mature fruit of gathering is removed sarcocarp and nucleocapsid, collects seed, dries.It mainly contains triterpene saponin and flavonoid, oils composition, reuses Semen Ziziphi Spinosae in the side, cures mainly in former side's function and strengthens nourishing blood to tranquillize the mind, stomach function regulating spleen invigorating, tonifying YIN arresting sweating on the basis; Radix Codonopsis, the function invigorating the spleen and replenishing QI is promoted the production of body fluid and nourished blood, and is very mutually not far away with Radix Ginseng, and with the same usefulness of Semen Ziziphi Spinosae two medicines, QI invigorating, nourish blood and develop simultaneously, be monarch drug altogether.Rhizoma Atractylodis Macrocephalae chemical constituent contains volatile oil 1.4%, and Pericarpium Citri Reticulatae volatile oil content is 1.5～2.0%, and for treatment cures mainly one of main active constituent of disease, in the side with the Rhizoma Atractylodis Macrocephalae spleen invigorating dampness, Poria, Semen Coicis spleen invigorating and eliminating dampness by diuresis; During Pericarpium Citri Reticulatae is regulated the flow of vital energy and is transferred, the fragrance dampness of being amusing, four medicines help the merit of Semen Ziziphi Spinosae, Radix Codonopsis activating the spleen altogether, and the insufficiency of the spleen stagnation of QI of can dispelling gives birth to and execute turbidly, are ministerial drug altogether.Fructus Setariae Germinatus is that the mature fruit of grass foxtail millet Setaria itlica (L.) Beauv. gets through the drying of germinateing.After foxtail millet paddy is soaked in water, keep suitable temperature, humidity, when treating that fibrous root grows to about 6mm, dry or cold drying.Fructus Setariae Germinatus and Radix Glycyrrhizae help digestion and in, spleen benefiting and stimulating the appetite, coordinating the actions of various ingredients in a prescription is to be adjuvant.Like this compatibility, QI and blood is taken into account, and resolving and invigoration therapies being applied simultaneously must be good for temper, cloudy blood winner, the multiple normal and strong body of rehabilitation of the fortune of receiving.
Main pharmacodynamics result of study of the present invention is:
(1) can obviously increase food ration and the body weight of rat, fat weight and fat index there is the trend of increase but no difference of science of statistics, but, show that this medicine has certain weight gaining effect to rat, the fat of not obvious increase animal to the obviously influence of the long nothing of the body of rat;
(2) can promote the mice gastric emptying, increase carbon powder propelling rate, promote enterokinesia, reserpine method model of spleen deficiency mouse small intestine D-xylose is absorbed with certain promotion, stomach total acidity, free acid and pepsin activity (P＜0.05) can obviously raise, show that this medicine can increase gastrointestinal motility, facilitating digestion absorbs;
(3) can increase liver glycogen and inose unit, and the trend that reduces serum blood glucose is arranged, show that this medicine has the synthetic effect of the glycogen of promotion;
(4) can obviously increase the mice swimming with a load attached to the body time, prolong the death time of mice normobaric hypoxia;
(5) macrophage phagocytic function of enhancing mice obviously increases mouse immune organ weight and immune organ organ index;
(6) reduce the spontaneous activity in mice number of times, shorten the time for falling asleep of threshold dose pentobarbital sodium hypnosis mice, obviously prolong its length of one's sleep.
Studies on acute toxicity of the present invention:
1, the maximum dosage-feeding of this Chinese medicine composition extract powder mouse stomach administration is 372g crude drug/kg/24h, and maximum administration multiple is 1329 times of 60kg body weight adult clinical oral administration day dosage.Observed 14 days the no abnormal symptom of animal ordinary circumstance, behavioral activity, defecation, fur, breathing and circulation behind the gastric infusion.Viewing duration, the body weight Non Apparent Abnormality of animal.After putting to death animal, perusal vitals (heart, liver, spleen, lung, kidney etc.) there is no unusually.The result shows that 1 extract powder safety range is bigger.
2,180 days administration toxicity is observed:
160 SD rats are divided into 4 groups at random, are respectively this Chinese medicine composition high dose group 28g/kg, middle dosage group 14g/kg, low dose group 7g/kg (being respectively clinical plan 100,50,25 times with dosage) and normal control group, all gavage administration, once a day, on every Saturdays day, continuous 180 days.
During whole administration, ingesting of low dose group rat obviously increases, body weight gain is faster, especially obvious with jenny, the relatively more indivedual indexs of hematological indices, blood parameters, organ coefficient and each internal organs histopathologic examination and normal control group are dispersed in and raise or reduction, but all do not have clinical meaning.
During whole administration, the middle equal Non Apparent Abnormality clinical symptoms of the female Mus of dosage group, ingest obviously increase, body weight gain is faster, especially obvious with jenny, the relatively more indivedual indexs of hematological indices, blood parameters, organ coefficient and each internal organs histopathologic examination and normal control group are dispersed in and raise or reduction, but all do not have clinical meaning.
During whole administration, equal Non Apparent Abnormality clinical symptoms during the high dose group administration, body weight and food ration increase; Administration 90 days, the male Mus HCT of high dose group, MCV obviously reduce (P＜0.05), RDWS significantly reduces (P＜0.01), MCHC significantly raise (P＜0.01), female Mus MCHC obviously raise (P＜0.05), the visible HCT of the whole rats of male and female, RDWS obviously reduce (P＜0.05), MCHC significantly raise (P＜0.01); Administration 180 days, the male Mus MCH of high dose group, MCHC obviously raise (P＜0.05), and female Mus RBC, HCT obviously reduce (P＜0.05), and MCH significantly raises (P＜0.01), and MCHC obviously raises (P＜0.05), and supposition is the normal physiological fluctuation of long term administration; Blood parameters, organ coefficient and each internal organs histopathologic examination and normal control group be no significant difference relatively.
In 30 days observation period of drug withdrawal, each organize rat the outward appearance symptom, ingest, equal Non Apparent Abnormality such as body weight gain, other every indexs are equal no significant differences also.
In sum, visible i.g1180 days nontoxic dose of SD rat is 14g/kg/day, for 50 times of clinical plan usefulness dosage, does not see the retardance toxic reaction.
For showing the therapeutic effect of medicine of the present invention to becoming thin, the present invention has done the clinical observation of system to the 120 examples patient that becomes thin:
Experimenter group: be diagnosed as the patient that the bodily form is become thin, had a delicate constitution through disease, the age is between 18-65 year, serious primary disease such as no cardiovascular, liver, kidney and psychosis.Becoming thin is meant that body weight is lower than standard body weight 10%, adult's standard body weight (kilogram)=(height centimetre-100) * 0.9
Dosage regimen: oral capsule of the present invention, each 3 (being equivalent to crude drug amount 5.4g), every day 3 times.The consumption per day of being grown up is equivalent to 1/50th of safe dose.If take other dosage form, also should follow this dosage generally speaking.Viewing duration, the experimenter need keep reasonable diet structure and work rest program, forbids the other drug of non-observation.
The course of treatment: 30 days
Treating the syndrome of spleen-deficiency of becoming thin is 75.21% through the total obvious effective rate of rough estimates, and effective percentage is 86.78%.To the become thin obvious effective rate of chronic superficial gastritis of syndrome of spleen-deficiency of genus is 75%, and effective percentage is 85.25%; The obvious effective rate of malabsorption syndrome is 75.00%, and effective percentage is 86.33%.In addition the become thin clinical symptoms of syndrome of spleen-deficiency of improvement is had obvious curative effects, especially to improving appetite go down, the curative effect of spiritlessness and weakness, lazy speech is better.Do not find that in the outpatient service process of clinical application this medicine has obvious adverse reaction, takes safety.
(4) description of drawings:
Accompanying drawing is process chart of the present invention
(5) specific embodiment:
Embodiment one:
Take by weighing raw material by following proportioning:
Semen Ziziphi Spinosae 450g Radix Codonopsis 400g Rhizoma Atractylodis Macrocephalae 150g Poria 200g Semen Coicis 200g
Pericarpium Citri Reticulatae 150g Fructus Setariae Germinatus 200g Radix Glycyrrhizae 50g starch 50g
Production method is as follows:
1, the alcohol extraction of Semen Ziziphi Spinosae: weigh by above-mentioned institute and to get Semen Ziziphi Spinosae, 70% ethanol (be Semen Ziziphi Spinosae: 70% ethanol is 1g:5ml) that adds 5 times of amounts of Semen Ziziphi Spinosae weight extracted 2 hours, with the filtration of 200 order filter clothes, filtrate for later use; Add 4 times of amount 70% ethanol extractions 2 hours again in filterable Semen Ziziphi Spinosae medicinal residues, filter, filtrate is merged, it is standby that recovery ethanol is concentrated into nothing alcohol flavor.
2, the extraction of volatile oil: get the Pericarpium Citri Reticulatae and the Rhizoma Atractylodis Macrocephalae, the water (be Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae: water is 1g:8ml) that adds Pericarpium Citri Reticulatae, 8 times of amounts of Rhizoma Atractylodis Macrocephalae weight soaked 30 minutes, distillating extracting oil 4 hours, and volatile oil filters, and the device preservation is standby in addition for distillate, and medicinal residues are standby.
3, the enclose of volatile oil: in order to keep volatile oil component as much as possible, guarantee curative effect, adopt cyclodextrin β-CDBao He total volatile oil.Add the β-CD (be β-CD: oil is 1g:6ml) of 6 times of amounts of volatile oil volume, fully stirred enclose 1 hour under 50 ℃ of conditions, 5 ℃ of cold preservations were placed 12 hours, and sucking filtration, clathrate drying under reduced pressure under 0.05mpa, 40 ℃ of conditions is standby.Volatile oil also can adopt the direct vexed system of traditional method.
4, drug decocting: Pericarpium Citri Reticulatae, Rhizoma Atractylodis Macrocephalae medicinal residues and Radix Codonopsis, Poria, Semen Coicis, Fructus Setariae Germinatus, the Radix Glycyrrhizae that will extract behind the volatile oil merge, the water (be medicine: water is 1g:10ml) that adds 10 times of amounts of drug weight decocted 2 hours, filter filtrate for later use with 200 order filter clothes; The decocting that adds 8 times of amounts in the medicinal residues after filtering boiled 1.5 hours, filtered filtrate for later use; The decocting that adds 8 times of amounts in the medicinal residues after filtering boiled 1 hour again, filtered, and merged three filtrates standby.
5, the distillate behind the alcohol extract of medicinal liquid that above-mentioned decoction is extracted and Semen Ziziphi Spinosae and extraction Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae volatile oil merges, be concentrated into the extractum of relative density 1.20～1.25 (60～70 ℃), with extract dry, be ground into 20 order powder, select 85% alcohol granulation after adding above-mentioned beta-CD inclusion and 50g starch mixing, dry back is encapsulated, makes hard capsule.
Below make 1000 of capsules altogether, every dress 0.3g, product is the brownish black granule, feeble QI perfume (or spice), bitter in the mouth.
The used adjuvant of this preparation all meets " two ones of Chinese pharmacopoeia versions in 2000 and Chinese Pharmacopoeia version pertinent regulations in 2005.
The working environment of packing should be 300,000 grades of clean areas (18～25 ℃ of room temperatures, relative humidity is below 55%).
Embodiment two:
Take by weighing raw material by following proportioning:
Semen Ziziphi Spinosae 400g Radix Codonopsis 300g Rhizoma Atractylodis Macrocephalae 150g Poria 200g Semen Coicis 150g
Pericarpium Citri Reticulatae 150g Fructus Setariae Germinatus 150g Radix Glycyrrhizae 40g magnesium stearate 5g sodium carboxymethyl cellulose 35g
Production method:
This production method is identical with the production method of embodiment one, different is above-mentioned make extract dry and be ground into fine powder after, add the above-mentioned tablet that is not pressed into different size behind the volatile oil of enclose and the 40g sucrose mixing that makes, because producing the method for tablet is traditional method, repeat no more here.
Embodiment three:
Take by weighing raw material by following proportioning:
Semen Ziziphi Spinosae 550g Radix Codonopsis 450g Rhizoma Atractylodis Macrocephalae 200g Poria 250g Semen Coicis 200g
Pericarpium Citri Reticulatae 200g Fructus Setariae Germinatus 200g Radix Glycyrrhizae 50g sucrose 30g dextrin 30g
Production method:
This production method is identical with the production method of embodiment one, and different is that the dosage form of making is a granule, is traditional method because produce particulate method, repeats no more here.
Product of the present invention also can be made soft capsule or drop pill as required.
Claims (8)
1, a kind ofly treat the Chinese medicine composition that the bodily form is become thin, had a delicate constitution, it is characterized in that it is the medicament of being made by following weight parts proportion raw material medicine:
Semen Ziziphi Spinosae 3～6 Radix Codonopsis 2.5～5 Rhizoma Atractylodis Macrocephalaes 1～2 Poria 1.5～2.5
Semen Coicis 1.5～2.5 Pericarpium Citri Reticulataes 1～2 Fructus Setariae Germinatus 1.5～2.5 Radix Glycyrrhizaes 0.3～0.6.
2, the treatment bodily form according to claim 1 Chinese medicine composition of becoming thin, having a delicate constitution is characterized in that wherein the weight portion proportioning of each crude drug is:
Semen Ziziphi Spinosae 4～5.5 Radix Codonopsis 3～4.5 Rhizoma Atractylodis Macrocephalaes 1.5～2 Poria 2～2.5
Semen Coicis 1.5～2 Pericarpium Citri Reticulataes 1.5～2 Fructus Setariae Germinatuss 1.5～2 Radix Glycyrrhizaes 0.4～0.5.
3, the treatment bodily form according to claim 1 Chinese medicine composition of becoming thin, having a delicate constitution is characterized in that wherein the weight portion proportioning of each crude drug is:
Semen Ziziphi Spinosae 4.5 Radix Codonopsis 4 Rhizoma Atractylodis Macrocephalaes 1.5 Poria 2
Semen Coicis 2 Pericarpium Citri Reticulataes 1.5 Fructus Setariae Germinatuss 2 Radix Glycyrrhizaes 0.5.
4, the Chinese medicine composition of becoming thin, having a delicate constitution according to claim 1 or the 2 or 3 described treatment bodily forms is characterized in that said medicament is any peroral dosage form.
5, the treatment bodily form according to claim 4 Chinese medicine composition of becoming thin, having a delicate constitution is characterized in that said medicament is capsule, soft capsule, drop pill, tablet or granule.
6, the preparation method of the treatment bodily form according to claim 5 Chinese medicine composition of becoming thin, having a delicate constitution, it is characterized in that getting Semen Ziziphi Spinosae, 60%～80% ethanol extraction of 4～6 times of amounts of adding 2～3 times, each time of extracting is 1～2 hour, filter merging filtrate; Get the Pericarpium Citri Reticulatae and the Rhizoma Atractylodis Macrocephalae, distillating extracting oil 3～12 hours was steeped in the water logging that adds 6～10 times of amounts 30～40 minutes; Volatile oil retains standby or with the clathrate of 4～8 times of amounts, 1～2 hour enclose of 30～50 ℃ of stirrings is standby; Medicinal residues after the extraction and all the other medicines merge, and the decocting that adds 8～12 times of amounts boils 2～3 times, and each time that decocts is 1～2 hour, filters merging filtrate; Medicinal liquid and said extracted liquid merge, and are concentrated into the extractum of relative density 1.20～1.25, and drying is ground into fine powder, add volatile oil and adjuvant that volatile oil or enclose are crossed, select 70～90% alcohol granulation, incapsulate after the drying, or make drop pill, or be pressed into tablet, or make granule.
7, the preparation method of the Chinese medicine composition of becoming thin, having a delicate constitution according to the described treatment bodily form of claim 6 is characterized in that: Semen Ziziphi Spinosae alcohol extraction 2 times, add 5 times of amount 70% ethanol extractions 2 hours for the first time, and add 4 times of amount 70% ethanol extractions 2 hours for the second time; The extraction conditions of volatile oil is that the water logging that adds 8 times of amounts was steeped 30 minutes, extracts 4 hours; The clathrate process of volatile oil is the β-CD with 6 times of amounts, and 50 ℃ were stirred enclose 1 hour; The decocting condition of medicine is 3 times, and the decocting that adds 10 times of amounts for the first time boiled 2 hours, and the decocting that adds 8 times of amounts for the second time boiled 1.5 hours, and the decocting that adds 8 times of amounts for the third time boiled 1 hour; Granulate and select 85% ethanol.
8, the preparation method of the Chinese medicine composition of becoming thin, having a delicate constitution according to claim 6 or the 7 described treatment bodily forms, it is characterized in that adjuvant is any one or a few combination of starch, magnesium stearate, sucrose, dextrin, calcium carbonate, sodium carboxymethyl cellulose, consumption is an extractum: the ratio of adjuvant is 2～6:1～3.
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| CN105685988A (en) * | 2016-03-04 | 2016-06-22 | 童松 | Bighead atractylodes rhizome, radix codonopsis and poria cocos cakes and making method thereof |
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2005
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