CN105077317A - Nutrition supplement used for promoting increasing of body heights of children and preparation method thereof - Google Patents
Nutrition supplement used for promoting increasing of body heights of children and preparation method thereof Download PDFInfo
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- CN105077317A CN105077317A CN201510501593.4A CN201510501593A CN105077317A CN 105077317 A CN105077317 A CN 105077317A CN 201510501593 A CN201510501593 A CN 201510501593A CN 105077317 A CN105077317 A CN 105077317A
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- nutritious supplementary
- supplementary pharmaceutical
- children
- liver kidney
- preparation
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
- A23C9/206—Colostrum; Human milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a nutrition supplement used for promoting the increasing of the body heights of children and a preparation method thereof, relating to the field of food nutrition science. The nutrition supplement is characterized by comprising the ingredients of a calcium agent, a liver and kidney regulating agent, complex vitamins, amino acid and the like, and can be used for conditioning the development potential of the body heights of children from multiple aspects such as supplement of calcium and nutrients, regulation of the liver, kidney, spleen and stomach, and enhancement of immunity, promoting the effect that the development of the body height of the children exceeds the inherent genetic conditions and correspondingly improving the development of physiques and intelligence. The experiment data shows that the body height growth speed of the child who has ISS (Idiopathic Short Stature) and takes the nutrition supplement to prevent the ISS is obviously higher than that of the control group.
Description
Technical field
The present invention relates to health caring product prescription technology, particularly a kind of nutritious supplementary pharmaceutical for promoting children to increase and preparation method thereof.
Background technology
The development condition of height judges the standard whether child's health is healthy, and it affects the every aspect of child growth process and the life after growing up, and therefore the height growth of children is one of problems of paying close attention to the most of father and mother.
Finally can grow how high factor is divided into the aspect that h and E two is large to affect people.First aspect, inherent cause belongs to genetic prerequisite, and namely the genetic profile that affect height of the height situation of father and mother in other words entrained by father and mother, cannot change.Second aspect environmental factor, and environmental factor is divided into endocrine and non-endocrine reason, endocrine reason mainly comprises that growth hormone secretion deficiency that a variety of causes causes, sex premature, thyroid gland energy supply are low, the emerging syndrome in storehouse etc., and endocrine reason gives appropriate treatment and then can correct in time after can diagnosing.But not endocrine reason then refers to the eating habit formed in raising day after tomorrow process, exercise habit, home environment, the nutrition intake that the factors such as sleep habit cause not, incomplete, partial eclipse, taste absorbability is weak, it is irregular or not enough to sleep, hypomotility or motion mode incorrect, feelings will is at a low tide etc. causes child height depauperation.
Have survey data to show, the motion mode of comprehensive, balanced nutrition intake, correct appropriateness, children how long 5-10 centimetre on the basis of genetic condition can be impelled in the diet of rule and joyful four aspects of sufficient sleep and mood.And the height growth that actual conditions are many people does not even play the height that its genetic condition is given.
Rationally balanced nutritious is the material base ensureing growth, bad maturity and the length affecting bone of long-term nutrition.But the fat youngster of overnutrition, particularly blindly takes in various tonic person, long with growing in advance, cause height to stop growing in advance.
Appropriate exercise improves one's physical development and constitutional key factor, takes regular exercise and can promote skeletal calcium phosphorus metabolism, accelerates the interior precipitation of bone of mineral matter, make bone density increase enhancing development.But long-term excess load motion easily causes cartilage damage, muscular strain, hinders the growth of height on the contrary.
The sleep of abundance, rule, ensures that the auxin relevant to height growth is secreted regularly sufficiently.
Whether the mood of children joyful, is also the key affecting height growth, if growth period be in for a long time pressure large, depressed, there is no the sense of security, under the interference of the psychological factors such as sense of frustration, the function of health each side can be affected, and then affect height growth.
In above four aspect factors, nutrition intake head ought be wherein most important factor, provides sufficient nutrition to be the prerequisite that child grows tall, and is provide enough cement steels continually just as prerequisite in architectural engineering.And being related in the nutrition of height, the absorption of calcium is again the most important thing.The supplementary attention being always subject to the head of a family of calcium, but have gap between the absorption of calcium and real absorption, main cause is wherein by the effective absorption all affecting calcium such as whether appropriate of the forming of calcium, compatibility between formulation, kind, calcium and other coherent element; The situations etc. such as the another kind of main cause affecting calcium uptake is children's torso situation, and such as taste, kidney deficiency and liver, hypoimmunity, metabolism are slow determine whether take in can by Cell uptake and then the calcium constituent be converted into needed for bone to the calcium in mouth; Further factor, whether lack other restriction nutriment in addition, such as, Zn-ef ficiency, whether the absorption of magnesium elements etc. matches with the intake of calcium.Generally speaking, the nutrition intake in height growth relates to systematically nurses one's health health/psychologic status, and the calcium of absorption and related nutritional can efficient absorption be utilized.
Although rely on the convenient of current knowledge dissemination, a lot of educating knowledge, medical knowledge become general knowledge, and these general knowledges have the feature of fragmentation, not architectonical, and various medical institutions do not have system for the section office of height growth problem aspect yet.The heads of a family are in the process raised a Child, and the various educating knowledge of acquisition are all tomography formulas, scattered here and there, are difficult to effectively apply, during problem hypogenetic in the face of child height, are difficult to propose measure that is appropriate, system.For nutrition intake aspect, the heads of a family or give too surplus, or provide not enough, or the food nutrition provided is comprehensive, and calcium complement agent is also multifarious on the market, makes us being difficult to accept or reject.
Summary of the invention
The present invention is based on blank and the demand in above-mentioned field, providing a kind of for promoting that juvenile's height can the nutritious supplementary pharmaceutical of normal development, without any hormone, can long-term taking, the height growth of children can be impelled to exceed the genetic condition of itself.The technical scheme of request protection of the present invention is as follows:
The nutritious supplementary pharmaceutical increased for promoting children, is characterized in that: comprise following components by weight percent:
Preferably comprise following components by weight percent:
Also comprise liver kidney conditioning agent, composition and the weight portion of each constitutive material in described nutritious supplementary pharmaceutical of described liver kidney conditioning agent are:
Composition and the weight portion of each constitutive material in described nutritious supplementary pharmaceutical of further preferred described liver kidney conditioning agent are:
Described liver kidney conditioning agent also comprises the membrane of a chicken's gizzard 1-3 part.
Described nutritious supplementary pharmaceutical, also comprises vitamin, and the weight portion of each constitutive material of described vitamin in described nutritious supplementary pharmaceutical is:
The raw material of described Cholecalciferol mix preparation is composed as follows:
Further preferably, described nutritious supplementary pharmaceutical, also comprises TYR 0.1-0.2 part, L-Histidine 0.1-0.15 part, ILE 0.1-0.15 part.
Further preferably, described nutritious supplementary pharmaceutical, also comprises green algal extract 1-2 part.
Further preferably, described nutritious supplementary pharmaceutical, also comprises zinc gluconate 0.15 part.
Further preferably, described nutritious supplementary pharmaceutical, also comprises auxiliary material,
In described auxiliary material, the components by weight percent of various raw material in nutritious supplementary pharmaceutical is as follows:
Anhydrous crystal glucose 18 parts,
1.5 parts, magnesium chloride,
DL-malic acid 0.9 part,
Dolomol 0.95 part,
Hydroxypropyl methylcellulose 0.57 part,
Quercetin 0.45 part,
Glycerine (glycerine) 0.03 part.
The preparation method of arbitrary described nutritious supplementary pharmaceutical, comprise the steps: to prepare raw material according to weight ratio, after pulverizing, mix, granulate, compressing tablet is dry.
For regulating a Chinese medicine composition for liver kidney, comprise following components by weight percent
Composition and the weight portion of each constitutive material in described nutritious supplementary pharmaceutical of preferred described liver kidney conditioning agent are:
The present invention provides a series of nutritious supplementary pharmaceutical from the compatibility of calcium agent, the collaborative supplementary multifactor consideration such as other nutrient and function of spleen and stomach regulating liver kidney.
In some embodiments of the present invention, provide a kind of nutritious supplementary pharmaceutical, its feature there are provided the calcium agent with unique proportioning, calcium containing rational inorganic origin and the calcium of organic origin, wherein fishbone dust, oyster shell whiting provides inorganic calcium, and bovine colostrum extract provides abundant organic calcium, and having research to observe display bovine colostrum extract can promote osteoblastic proliferation; CPP is for promoting that human body is to the absorption of the divalent mineral nutrients such as calcium, iron, zinc and utilization, and colostrum contains abundant immunoglobulin (Ig), can improve immunity of organisms.The invention provides the accurate proportioning between organic calcium/inorganic calcium, CPP cpp, colostrum, the calcium in the nutritious supplementary pharmaceutical of this proportioning gained is balanced in whole day 24 hours to be absorbed, and improves the absorptivity of calcium on the whole.And the absorption of calcium agent known at present mainly absorbs better at night.
In other embodiment of the present invention, in the nutritious supplementary pharmaceutical provided, adding can the extract of Chinese medicine of integration of drinking and medicinal herbs, comprises yam extract, Fructus lycii P.E, Schisandra chinens P.E, Astragalus Root P.E, Cortex Acanthopancis extract.These Chinese medicines have the effect regulating hepatic and renal function, strengthening taste, set about leniently regulating, make it no matter be can absorb efficiently for common food or calcium agent from the function of children's the five internal organs.
Wherein Chinese yam is the Chinese medicine of medicine-food two-purpose, and another name RHIIZOMA DIOSCOREAE from Henan of China, mountain Chinese yam, numb Chinese yam, Chinese yam, have invigorating spleen and reinforcing stomach, digestant effect, the plump succulence of Chinese yam stem tuber, not only sweet but also continuous, and band viscosity, it is all delicious for eating heat food raw.According to the result of laboratory test of academy of agricultural sciences of Shandong Province to Chinese yam, average containing thick protein 14.48% in its stem tuber, crude fibre 3.48%, starch 43.7%, sugar 1.14%, potassium 2.62%, phosphorus 0.2%, calcium 0.2%, magnesium 0.14%, ash content 5.51%, iron 53.57ppm, zinc 29.22ppm, copper 10.58ppm, manganese 5.38ppm.In 18 seed amino acids of necessary for human, containing 16 kinds in Chinese yam.
The wherein fruit of Chinese wolfberry, for the ripening fruits of matrimony vine of solanaceae plant, there is various health care functions, the medicine-food two-purpose food of Ministry of Public Health's approval, containing abundant carrotene, multivitamin and calcium, iron etc., nourishing liver and kidney, benefiting shrewd head, for syndrome of yin deficiency of liver and kidney, flat filling liver kidney, improves children physique balanced development.
The fruit of Chinese magnoliavine is the dry mature fruit of magnoliaceae schisandra Schisandrachinensis (Turcz.) Baill. or schisandra chinensis SchisandrasphenantheraRehd.etWils..Have and astringe the lung, nourshing kidney, the effect of promoting the production of body fluid, record them in many medical books and also can be used for indigestion, appetizing, enteritis etc. and have and digest and assimilate relevant symptom, as recorded in " hiding book on Chinese herbal medicine ", its fruit is used for indigestion, enteritis, diarrhea, vomiting hiccup, gas pain, faint dizzy, numb limb is unable." Chinese Tibetan medicine " fruit is controlled and is rushed down dysentery, vomiting, appetizing.Amplification on Canon of Materia Medica: the fruit of Chinese magnoliavine, " herbal classic " Yan Wen, cause abnormal heat more than modern food, children's's benefit very.The Radix Astragali, Latin literary fame Astragalusmembranaceus (Fisch.) Bunge. root is used as medicine, and returns lung, spleen, liver, kidney channel.It has enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely, the pure natural product that the common people often eat, be usually used in that with the passing of time body declines, speech is low, small and weak pulse person, there is air making-up and spleen enlivening, energy coronary artery dilator, improve myocardial blood supply, improve immunologic function.
Cortex acanthopanacis, is the dry root skin of Araliaceae acanthopanax gracilistylus Acanthopanargracilist μ lusW.W.Smith, returns liver, kidney channel.Have wines used as antirheumatic, tonify the liver and kidney, strengthen muscles and bones, the effect of inducing diuresis for removing edema, for Bi condition, muscles and bones impotence is soft, children's's retardation of walking, and body void is weak, oedema, beriberi.
The fleece-flower root, formal name used at school: Fallopiamultiflora (Thunb.) Harald. is that the polygonaceae knotweed race fleece-flower root belongs to perennial winding liana, and block root is used as medicine, and enters spleen, lung, kidney three warp.Primary efficacy: nourishing the blood and yin; Relax bowel; Preventing malaria; Dispel the wind; Removing toxic substances.Compendium of Material Medica: this thing temperature bitter and puckery flavor, bitter kidney tonifying, temperature compensation liver, can restrain vital essence, so beneficial liver of nourishing blood, controlling nocturnal emission with astringent drugs kidney-nourishing, muscle reinforcing and bone strengthening, Wu Fa is tonic medicine, and cold not dry, merit is on glutinous rehmannia, all medicines of lucid asparagus.Qi and blood Taihe county, then wind is empty, carbuncle is swollen, all diseases of scrofula known (removing).
Safflower, (Classification system: CarthamustinctoriusL.), another name: red indigo plant flower, thorn safflower, the fruit of composite family, safflower platymiscium.The safflower polysaccharide that it is rich in, has the effect improving immunity.Division and the regeneration of bone tissue can be promoted, promote synthesis and the deposition of mineral matter in bone of cartilaginous tissue cell, prevent osteoporosis.
The bark of eucommia, (formal name used at school EucommiaulmoidesOliver), has another name called bakelite, is the dry bark of the Eucommiaceae plant bark of eucommia, is Chinese famous and precious tonic herb.Its taste is sweet, warm in nature.Have tonify the liver and kidney, strengthen muscles and bones, effect of coordinating Chong and Conception Vessels.The modern study bark of eucommia has rubbish in purged body, strengthens human body cell metabolism, prevents muscle skeleton aging, balanced human's blood pressure, decomposer inner cholesterol, reduces body fat, recovers blood vessel elasticity, diuresis heat-clearing, broad-spectrum antiseptic, stimulating central nervous system, improves white blood cell pharmacological action.
The nutritious supplementary pharmaceutical provided in other embodiment of the present invention, preferably with the addition of B B-complex, wherein comprises vitamine D3, vitamin C and vitamin B6.Vitamine D3 promotes that small intestine is to the absorption of calcium, phosphorus; Vitamin b6 is body fat and glycometabolic required material, and the constituent of some coenzyme in human body, participate in multiple metabolic response, especially have substantial connection with amino acid metabolism, human body can not synthesize, and needs by food or supplements specially.Vitamin C, human body can not synthesize, that antibody and collagen are formed, the metabolism of tissue repairing, phenylalanine, tyrosine, folic acid, the utilization of iron, carbohydrate, the synthesis of fat, protein, maintains immunologic function, keep the complete of blood vessel, promote the necessary materials of physiological activity such as nonheme iron absorption.Vitamin E nutritious supplementary pharmaceutical of the present invention, after with the addition of these B B-complexes, more fully can supplement this several vitamins required in upgrowth and development of children process.
In a further embodiment, also zinc oxide, the membrane of a chicken's gizzard is preferably added in nutritious supplementary pharmaceutical of the present invention, the nutriment such as amino acid and/or green algal extract, optimizes nutritional supplementation effect of this nutritious supplementary pharmaceutical further, impels various material composition in nutrient to absorb better.
Wherein the effect of zinc gluconate is to provide zinc, and zinc is present in numerous enzyme systems, as carbonic anhydrase, and respiratory enzyme, LDH, superoxide dismutase, alkaline phosphatase, during DNA and RNA is poly-in enzyme etc., for nucleic acid, protein, the utilization institute of the synthesis of carbohydrate and vitamin A is required.Zinc has enhancing development, improves the effect of the sense of taste.Occur the sense of taste during zinc deficiency, sense of smell is poor, apocleisis, and growth and intelligence development are lower than normally.
The membrane of a chicken's gizzard is the dry inner wall of sandbag for Phasianidae animal man chicken GallusgallusdomesticusBrisson, has wide middle invigorating the spleen, the effect of the mill stomach that helps digestion, and control children's's breast food knot stagnant, the large muscle of tripe is blue or green, mass in the abdomen infantile malnutrition due to digestive disturbances or intestinalparasites.
Compound amino acid, comprises TYR, L-Histidine, ILE.Wherein tyrosine is nonessential amino acid, is the primary raw material of the medicines such as improvement on synthesis parahormone, antibiotic, L-3,4 dihydroxyphenylalanine; L-Histidine is a kind of semi-dispensable amino acid, and the growth for infant and animal is even more important, and can promote the absorption of iron, for preventing and treating anaemia; ILE, participates in adjustment and the metabolism of thymus gland, spleen and infracerebral gland; Infracerebral gland belongs to general headquarter and acts on thyroid gland, sexual gland.
Green algal extract, green alga contains the almost complete nutritional labeling of needed by human body, can supply the sufficient nutrient of human body.Except some familiar nutriment minerals and vitamins, green alga is also containing some effective compositions, and can make the lactic acid bacteria in intestines as green alga essence composition, Bifidobacterium Bifidum becomes 4 times of growths, promotes the Environmental Health in intestines; Lutein, can prevent intraocular lutein premature aging and harm one's eyes; Also there is promotion enterocinesia, eliminate the obvious effect of constipation.Have and significantly strengthen muscle power, dispelling fatigue and strengthen effect that is mental and notice.
The present invention also asks the liver kidney conditioner formulations of adding in separately protected nutritious supplementary pharmaceutical of the present invention; medicine all integration of drinking and medicinal herbs of the liver kidney conditioning agent employing of this formula; this conditioning agent leniently regulates children physique from many aspects such as adjustment liver kidney, spleen benefiting and stimulating the appetite, develop immunitypty; promote that health is for the defensive ability/resistance ability of germ, and the absorbability to nutriment.Experimental data shows, after adding this conditioning agent, lower for the resistance, the symptom such as apocleisis, indigestion, anorexia of children obviously disappear and at least improve.
The present invention also asks the preparation method protecting above-mentioned nutritious supplementary pharmaceutical.
Detailed description of the invention
Below by way of detailed description of the invention, product preparation method of the present invention and effect are described.
Experiment material and source
CPP cpp: casein, purchased from Gannan Keri Dairy Products Development Co., Ltd..
Fishbone dust: burn till, calcic more than 35%.
Oyster shell whiting: non-ly to burn till, calcic more than 35%.
Taurine: food-grade.
Bovine colostrum extract: brand: " Sheng Bide " bovine colostrum extract sheet.
Colostrum: brand: " soup minister is doubly good for " colostrum milk powder.
Yam extract preparation: containing solid extract 20%, dextrin 80%, Shifang City, Sichuan Province Hua Kang medicine material factory.
Fructus lycii P.E preparation: containing solid extract 25.8%, dextrin 74.2%, Shifang City, Sichuan Province Hua Kang medicine material factory.
Schisandra chinens P.E preparation: containing solid extract 27%, dextrin 73%, Changbai Mountain, Jilin Province pharmaceutcal corporation, Ltd.
Astragalus Root P.E preparation: containing solid extract 50%, dextrin 50%, Shifang City, Sichuan Province Hua Kang medicine material factory.
Cortex Acanthopancis extract preparation: divide extract 30% containing solid, dextrin 70%, Changbai Mountain, Jilin Province pharmaceutcal corporation, Ltd.
Kardiseed extract formulation: divide extract 30% containing solid, dextrin 70%, Jing Hong bio tech ltd, Guangzhou.
Radix-polygoni multiflori extract preparation: solid extract 40%, Stockings scholar dextrin 60%, Shaanxi normal celestial movement biochemical technology Co., Ltd.
Eucommia ulmoides extracts preparation: solid divides extract 30%, dextrin 70%, Xi'an Chang Yue plant Chemical Co., Ltd..
Vitamine D3, vitamin C, vitamin E, vitamin B6, vitamin B2, TYR, L-Histidine, ILE, pharmaceutical grade, general pharmacy can buy.
The membrane of a chicken's gizzard: Chinese medicine pharmacy can buy.
Zinc gluconate tablet: breathe out medicine
Green algal extract: divide extract 20% containing solid, dextrin 80%, Rayleigh, Xi'an bio tech ltd
Additive of tablet: anhydrous crystal glucose, magnesium chloride, DL-malic acid, dolomol, hydroxypropyl methylcellulose, Quercetin, food-grade.
The preparation of embodiment 1. nutritious supplementary pharmaceutical 1-7 of the present invention.
The nutritional supplementation agent prescription of table 1. the preferred embodiments of the present invention
Wherein, " vitamin e preparation ": containing alpha-tocopherol 50%, dextrin 30%, fish gel 20%
" vitamine D3 preparation ": Cholecalciferol 0.25%, alpha-tocopherol 0.001%, peanut oil 0.75%, Arabic gum 0.667%, glucose 1.585%, vitamin C 0.003%, sodium acetate 0.01%, lactose 96.667%, sodium hypophosphite 0.036%.
Wherein yam extract preparation: containing Chinese yam solid extract 20%, dextrin 80%.The actual content of " yam extract " in above-mentioned formula is consumption × 20% of " yam extract preparation ", and the actual content of above-mentioned formula yam extract is (1 ~ 2.5) × 20%=0.2 ~ 0.5mg/ grain.
Fructus lycii P.E: containing fruit of Chinese wolfberry solid extract 25.8%, dextrin 74.2%.
Schisandra chinens P.E: containing fruit of Chinese magnoliavine solid extract 27%, dextrin 73%.
Astragalus Root P.E: containing Radix Astragali solid extract 50%, dextrin 50%.
Cortex Acanthopancis extract: divide extract 30% containing cortex acanthopanacis solid, dextrin 70%.
Kardiseed extract formulation: divide extract 30% containing solid, dextrin 70%.
Radix-polygoni multiflori extract preparation: solid extract 40%, dextrin 60%.
Eucommia ulmoides extracts preparation: solid divides extract 30%, dextrin 70%.
Tablet nutrient tablet, preparation process is as follows
Step 1: the raw material preparing each formula by table 1.
Step 2: 80 mesh sieves crossed by pulvis raw material; The raw materials such as tablet material carries out pulverizing, bovine colostrum extract tablet, the membrane of a chicken's gizzard are pulverized, and cross 80 mesh sieves.
Step 3: mix various pulvis stock and adjunct by the formula rate of table 1, adds appropriate distilled water blend feedstock and makes softwood, crosses 16 sieve series grains, particle after 40-60 degree Celsius of drying, then through the whole grain of 14 mesh sieve, then compressing tablet.
The effect statistical experiment of embodiment 2. nutritious supplementary pharmaceutical of the present invention.
1. choose and be diagnosed as idiopathic short stature ISS infant totally 724 examples from 2007.1 ~ 2010.10; Carry out meddler 364 example, man 170 example, female 194 example; Do not carry out any meddler 360 example, man 164 example, female 196 example.
2. idiopathic short stature ISS diagnostic method with make a definite diagnosis foundation
1. disease history inquire: mother's gestation history, childbirth options, Gestational age, body weight, infant feeding history, childhood nutrition, disease condition, the height of parents and Development in Puberty history, genetic disease etc.
2. physical examination: height, body weight, figure etc.
3. laboratory examination: selectively carry out blood, routine urinalysis, liver function, GH provocation test, first merit three, sex hormone measurement etc.
ISS [1] is made a definite diagnosis: height is lower than the same age, with sex normal height average 2 standard deviations (or below the 3rd hundredths) according to ISS diagnostic criteria; Birth length in same gestational age height normal range (NR), Normal-weight; Stature ratio is normal; Without chronic organic illness; Without psychological disease or major affective disorders, food intake is normal; Chromosome examination is normal; The whole growth course speed of growth is slow or normal; Stone age normally or slightly postpones; GH provocative test: GH peak value >10ug/L; Get rid of known other reasons; Prediction of height is difficult to reach normal growth height.
3. case grouping
The ISS infant made a definite diagnosis is set up intervention group according to the age:
Preschool intervention group: 3-7 year, man 12 example, female 15 example; Totally 27 examples are subdivided into 3 groups, often organize 7 people;
School age intervention group: 7-13 year, man 88 example, female 7-11 year, man 86 example; Totally 174 examples, are subdivided into 14 groups, often organize people 12-13 people;
Puberty intervention group: 13-17 year, man 70 example, female 11-17 year, 93 example; Totally 163 examples, are subdivided into 13 groups, often organize people 12-13 people;
Corresponding control group is set up according to the age:
Preschool control group: 3-7 year, man 18 example, female 28 example;
School age control group: male 7-13 year, 94 examples, female 7-11 year, 106 examples;
Puberty control group: male 13-17 year, 42 examples, female 11-17 year, 60 examples.
4. experimental technique
364 routine ISS infants, three age groups add up to 30 groups, the nutritious supplementary pharmaceutical of 7 formulas listed by Random assignment table 1:
Preschool group: early 1, evening 2;
School age group: every day 2 times, each 3;
Puberty group: early 4, evening 5.
360 routine ISS infant control groups: do not give any intervening measure.
5. observe and follow up a case by regular visits to index
Detect infant height before treatment, body weight, year the speed of growth, take the photograph left hand, elbow stone age sheet.Follow up a case by regular visits to intervention height after 12 months, year the speed of growth.
6. statistical procedures
Application SPSS17.0 software is analyzed, and data x ± s represents, the t that intervention group and control group adopt two independent sample means to compare checks, and P<0.05 is that difference has statistical significance.
7. result
Formula 1-7 intervene group year statural growth speed compared with control group, statistics display be all significantly increased.
The group that formula 4-7 intervenes year statural growth speed compared with the group that intervenes of formula 1-3, statistics shows and significantly improves, illustrate that the liver kidney conditioning agent of the integration of drinking and medicinal herbs added in nutritious supplementary pharmaceutical of the present invention is conducive to promoting that children are to the overall absorption of nutrition and utilization, promote height growth.
The nutritious supplementary pharmaceutical below listing formula 7 intervenes statistics as table 1-table 4.
The 7 intervention group treatment speeds of growth the year before last of filling a prescription table 1. compare with the treatment speed of growth in the year after next
Note: (1) have significant difference (p<0.05) with the treatment speed of growth in the year after next before preschool intervention group infant treatment.
(2) there is significant difference (p<0.05) with the treatment speed of growth in the year after next before school age intervention group infant treatment.
(3) there is significant difference (p<0.05) with the treatment speed of growth in the year after next before intervention group infant treatment in puberty.
Table 2. is filled a prescription the height of 7 preschool intervention group and preschool control group, the comparing of the year speed of growth
Note: (1) height there was no significant difference before preschool intervention group and preschool treatment of control group.
(2) preschool intervention group intervention height in December and preschool control group height in December there was no significant difference.
Preschool intervention group year the speed of growth and preschool control group year the speed of growth have significant difference (p<0.05).
Table 3. fill a prescription 7 school age group with the height of school age control group, the comparing of the year speed of growth
Note: (1) school age intervention group and school age treatment of control group before height have significant difference (p<0.05).
(2) intervention group intervenes height and preschool control group height in December there was no significant difference in December school age
(3) intervention group school age, speed of growth year and control group school age, speed of growth year have significant difference (p<0.05)
Table 4. fill a prescription 7 puberty group with the height of control group in puberty, the comparing of the year speed of growth
Note: (1) puberty intervention group and puberty treatment of control group before height have significant difference (p<0.05)
(2) height and control group in puberty height in December there was no significant difference in December is intervened in puberty group infant intervention.
(3) intervention group in the puberty year speed of growth and control group in the puberty year speed of growth have significant difference (p<0.05).
Claims (10)
1. the nutritious supplementary pharmaceutical for promoting children to increase, is characterized in that: comprise following components by weight percent:
2. the nutritious supplementary pharmaceutical for promoting children to increase according to claim 1, is characterized in that: comprise following components by weight percent:
3. the nutritious supplementary pharmaceutical for promoting children to increase according to claim 1, also comprises liver kidney conditioning agent, and composition and the weight portion of each constitutive material in described nutritious supplementary pharmaceutical of described liver kidney conditioning agent are:
4. the nutritious supplementary pharmaceutical for promoting children to increase according to claim 3, composition and the weight portion of each constitutive material in described nutritious supplementary pharmaceutical of described liver kidney conditioning agent are:
5. the nutritious supplementary pharmaceutical according to claim 3 or 4, is characterized in that, described liver kidney conditioning agent also comprises the membrane of a chicken's gizzard 1-3 part, vitamin and/or amino acid,
The weight portion of each constitutive material of described vitamin in described nutritious supplementary pharmaceutical is:
The raw material of described Cholecalciferol mix preparation is composed as follows:
The weight portion of each constitutive material of described amino acid in described nutritious supplementary pharmaceutical is: TYR 0.1-0.2 part, L-Histidine 0.1-0.15 part, ILE 0.1-0.15 part.
6., according to the arbitrary described nutritious supplementary pharmaceutical of claim 1-4, it is characterized in that, also comprise green algal extract 1-2 part and/or zinc gluconate 0.15 part.
7., according to the arbitrary described nutritious supplementary pharmaceutical of claim 1-4, it is characterized in that, also comprise auxiliary material, in described auxiliary material, the components by weight percent of various raw material in nutritious supplementary pharmaceutical is as follows:
Anhydrous crystal glucose 18 parts,
1.5 parts, magnesium chloride,
DL-malic acid 0.9 part,
Dolomol 0.95 part,
Hydroxypropyl methylcellulose 0.57 part,
Quercetin 0.45 part,
Glycerine (glycerine) 0.03 part.
8. the preparation method of the arbitrary described nutritious supplementary pharmaceutical of claim 1-7, comprise the steps: to prepare raw material according to weight ratio, after pulverizing, mix, granulate, compressing tablet is dry.
9., for regulating a Chinese medicine composition for liver kidney, comprise following components by weight percent:
10. the nutritious supplementary pharmaceutical for promoting children to increase according to claim 3, composition and the weight portion of each constitutive material in described nutritious supplementary pharmaceutical of described liver kidney conditioning agent are:
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105456567A (en) * | 2016-01-12 | 2016-04-06 | 冯冰 | Traditional Chinese medicine composition for treating kidney-qi deficiency type idiopathic dwarfness |
| CN106923237A (en) * | 2015-12-30 | 2017-07-07 | 深圳市绿微康生物工程有限公司 | Application of the fishbone dust in bakery, functional food, drink |
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| CN1411747A (en) * | 2002-05-29 | 2003-04-23 | 赵广钧 | Production method of coated and shaped tablet health-care food with the functions of increasing body height and reducing weight for youngsters |
| CN1486719A (en) * | 2003-08-11 | 2004-04-07 | 合肥神鹿集团公司 | Chinese medicine for invigorating liver, kidney and spleen, nourishing blood, tranquilizing mind relaxing bowels and the prepn process of the Chinese medicine prepn |
| CN102415447A (en) * | 2011-12-06 | 2012-04-18 | 汉臣氏（沈阳）儿童制品有限公司 | Calcium supplement electuary for infants and preparation process thereof |
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| CN1116908A (en) * | 1995-03-07 | 1996-02-21 | 曹吉祥 | A health food additive containing Spirulina for promoting growth of children, and its preparation method |
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| CN1486719A (en) * | 2003-08-11 | 2004-04-07 | 合肥神鹿集团公司 | Chinese medicine for invigorating liver, kidney and spleen, nourishing blood, tranquilizing mind relaxing bowels and the prepn process of the Chinese medicine prepn |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106923237A (en) * | 2015-12-30 | 2017-07-07 | 深圳市绿微康生物工程有限公司 | Application of the fishbone dust in bakery, functional food, drink |
| CN105456567A (en) * | 2016-01-12 | 2016-04-06 | 冯冰 | Traditional Chinese medicine composition for treating kidney-qi deficiency type idiopathic dwarfness |
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