CN1486719A - Chinese medicine for invigorating liver, kidney and spleen, nourishing blood, tranquilizing mind relaxing bowels and the prepn process of the Chinese medicine prepn - Google Patents

Chinese medicine for invigorating liver, kidney and spleen, nourishing blood, tranquilizing mind relaxing bowels and the prepn process of the Chinese medicine prepn Download PDF

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CN1486719A
CN1486719A CNA031323189A CN03132318A CN1486719A CN 1486719 A CN1486719 A CN 1486719A CN A031323189 A CNA031323189 A CN A031323189A CN 03132318 A CN03132318 A CN 03132318A CN 1486719 A CN1486719 A CN 1486719A
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radix
fructus
semen
kidney
chinese medicine
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CN1219543C (en
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王志强
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HEFEI SHENLU GROUP CORP
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Abstract

The present invention relates to medicine technology, and solves the problem of providing Chinese medicine preparation with the functions of invigorating liver, kidney and spleen, nourishing blood, tranquilizing mind and relaxing bowels. The medicine preparation has the effective medicine components comprising huanq, white atractylodes rhizome, wolfberry fruit, rehmannia root, mulberry fruit and other 21 kinds of Chinese medicinal materials. The medicine may be prepared into oral liquid or paste, and is applied clinically for treating spleen and kidney asthenia, with the total effective rate being 93.3%

Description

The Chinese medicine of nourishing the liver and kidney, strengthening spleen and nourishing blood, mind tranquilizing and the heart calming, loosening bowel to relieve constipation and the manufacture method of preparation thereof
Technical field: the present invention relates to a kind of Chinese medicine and preparation method thereof, the Chinese medicine of particularly a kind of nourishing the liver and kidney, strengthening spleen and nourishing blood, mind tranquilizing and the heart calming, loosening bowel to relieve constipation and the manufacture method of preparation thereof.
Background technology: spleen, kidney are the basic internal organs of human body.Theory of Chinese medical science is thought: kidney storing essence, be the congenital foundation, and the root of life is so " element is asked golden deficient the truth opinion " said: " husband essence person, root of body is also ".The growth of kidney qi and human body, growth, aging have substantial connection.Upward say as " innocent opinion in ancient times " " ... five or eight, kidney qi declines, the trichomadesis withering of teeth ".The essence of aging phenomenon and kidney has internal relation.Essence of the kidney being reflected on the hair is had one's ideas straightened out in ear, and the essence of kidney is a gb 1, tooth being the surplus of the bone.So send out grey, hard of hearing, look boundless and indistinct, luxated tooth, all be the external presentation of old deficiency of kidney-essence.The spleen and stomach provide the material basis of the acquired, and the internal organs vital essence of human body all relies the life that essence of water and grain is supported of transporting and transforming function of the spleen and stomach." five tastes " are said: " vital organs of the human body are all reported the gas stomach ".And the aging of human body is relevant with deficiency of spleen-QI and stomach-QI.Spleen and stomach function is contained then healthy, and the taste weakness of QI then is to form old and feeble main key.Energy is human body " three essentials-essence ".Say in " Lei Zheng Zhi Cai ": " person institute is precious, only energy.God is born in gas, and gas is born in essence, essence can be changed into QI, blending of qi and spirit.So smart person's root of body, gas person god's master, shape person god's residence is also ".Though people's living matter has the branch of negative and positive of qi and blood, old and feeble mechanism is with advancing age, at first is that essence and blood is disconnected attenuation, and the deficiency of vital energy, the god who continues loses, senile appearance and senile.As seen the decline of energy is old and feeble outstanding feature.In sum, old and feeble main pathogenesis is deficiency of the liver and kindey, deficiency of both the heart and spleen, is main principle so control with " tonify deficiency benefit damage, strengthening the body resistance ", and promptly with nourishing the liver and kidney, strengthening spleen and nourishing blood is main.
Summary of the invention: technical problem to be solved by this invention is: a kind of the have Chinese medicine of nourishing kidney spleen invigorating, mind tranquilizing and the heart calming, enriching blood for moistening the intestine effect and the manufacture method of preparation thereof are provided.Its technical scheme is: the Chinese medicine of a kind of nourishing the liver and kidney, strengthening spleen and nourishing blood, mind tranquilizing and the heart calming, loosening bowel to relieve constipation is characterized in that its composition and effectiveness and percentage by weight thereof:
Radix Astragali 6-10 Rhizoma Atractylodis Macrocephalae 4-8 Fructus Lycii 6-10 Radix Rehmanniae 2-6
Fructus Mori Poria cum Radix Pini 6-10 6-10 Semen Cuscutae 2-6 Semen Euryales 6-10
Radix Ophiopogonis 1-3 Radix Codonopsis 2-6 Radix Rehmanniae Preparata 1-3 Semen Nelumbinis 1-3
Rhizoma Polygonati 2-6 Radix Glycyrrhizae 1-3 Fructus Corni 1-3 Radix Polygoni Multiflori 2-6
Rhizoma Dioscoreae 1-3 Rhizoma Polygonati Odorati 2-6 Fructus Schisandrae Chinensis 2-6 Semen Platycladi 1-3
Radix Salviae Miltiorrhizae 1-3 Placenta Hominis 2-6 Arillus Longan 1-3 dried Fructus Vitis viniferae 2-6
Semen sojae atricolor 2-6 Fructus Mume 0.6-1.0
The manufacture method of its oral liquid is: 20 flavors such as the Radix Astragali, Fructus Lycii, Semen Euryales, the Rhizoma Atractylodis Macrocephalae, Semen Nelumbinis, Radix Codonopsis, Radix Glycyrrhizae, Fructus Corni, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, Semen Platycladi, Radix Salviae Miltiorrhizae, Arillus Longan, dried Fructus Vitis viniferae, Semen sojae atricolor, Fructus Mume, Poria cum Radix Pini, Radix Ophiopogonis, Fructus Mori are decocted with water three times, each 1 hour, collecting decoction is condensed into fluid extract after the filtration; Four flavors such as Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Polygoni Multiflori are decocted with water three times, and each 1 hour, collecting decoction filtered the back with charcoal treatment once, and reconcentration becomes fluid extract; Semen Cuscutae adds water decocts a drug wrapped each 1 hour three times; Placenta Hominis adds the water list fries in shallow oil each 0.5 hour three times; Merge above-mentioned each extracting solution, add doubling dose 75% ethanol, stir, left standstill 24 hours, filter, filtrate recycling ethanol, concentrated solution stirs evenly with sucrose, sodium benzoate, filters, and adds water to ormal weight, leaves standstill 48 hours, filters, promptly.Product is henna liquid, and it is sweet to distinguish the flavor of.
The manufacture method of its unguentum is: the Radix Astragali, Fructus Lycii, Semen Euryales, the Rhizoma Atractylodis Macrocephalae, Semen Nelumbinis, Radix Codonopsis, Radix Glycyrrhizae, Fructus Corni, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, Semen Platycladi, Radix Salviae Miltiorrhizae, Arillus Longan, dried Fructus Vitis viniferae, Semen sojae atricolor, Fructus Mume, Poria cum Radix Pini, Radix Ophiopogonis, Fructus Mori, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Polygoni Multiflori, Semen Cuscutae and Placenta Hominis 20 Six-element medical materials are decocted with water three times, be respectively 3,2,1 hours at every turn, place precipitation, filter, filtrate merges, be concentrated into relative density and be 1.28 clear paste, add sugar refinery and make.
Chinese medicine of the present invention forms according to the marrow compatibility of the defying age theory of traditional medicine " regulating yin and yang, guarantor's kidney storing essence, spleen reinforcing stomach reinforcing, foster just eliminating evil ", effect with nourishing the liver and kidney, strengthening spleen and nourishing blood, mind tranquilizing and the heart calming, loosening bowel to relieve constipation, through clinical 89 routine asthenia of both the spleen and kidney are demonstrate,proved to clothes Chinese medicine oral liquid of the present invention, the clinical efficacy of patient's cardinal symptom is all reached more than 90%.Its clinical data and data are as follows:
1, MethodsThe cases enrolled 89 examples all meet the dialectical standard of asthenia of both the spleen and kidney (can formulate " the dialectical reference standard of Chinese medicine deficiency-syndrome " according to Zhengzhou in 1986).
2, observation index:
(1) asthenia of both the spleen and kidney card cardinal symptom and grade scale:
Loss of appetite
Slight (+) no appetite, but keep former appetite
The no appetite of moderate (++), appetite reduces 1/3 than before sick
Severe (+++) no appetite, appetite reduces more than 1/3
Soreness of waist and knee joint
Slightly (+) is tired slightly, the power of not enduring hardships, but can adhere to slight power activity
Moderate (++) asthenia is supported daily routines more reluctantly
Severe (+++) spiritual tired, myasthenia of limbs can not be adhered to daily routines
Appetite abdominal distention
Slightly (+) abdominal distention alleviates in half an hour or disappears, and does not influence life, the moderate (++) of need not taking medicine abdomen
Expand in half an hour to 1 hour more very, need the clothes symptomatic drugs
Severe (+++) abdominal distention still can not take a turn for the better in 2 hours, needed the clothes symptomatic drugs
Insomnia and dreamful sleep
Slightly (+) sleep is waken up often or is slept and unstable waking up too early, but does not influence work
Moderate (++) was not had enough sleep 4 hours, but can adhere to work
Severe (+++) do not have enough sleep 4 hours, be difficult to adhere to operate as normal
Above cardinal symptom according to light, in, counted 1,2,3 fen heavily respectively, to add up its symptom curative effect.
(2) memory ability test: when utilizing ibm computer human computer conversation method test numerical span memory achievement (MS) and memory to answer reaction (RT), be that the ibm computer screen is with per speed that shows Arabic numerals 0.5 second, can show different 3 at random, 6,9,12,15 figure places, contiguous two-digit does not repeat in the numerical string of bits per inch, 0.5 second after last digit shows, whole numeric string disappears on screen automatically, and want the experimenter to begin immediately to answer, the same numeric string on the keypad is answered in experimenter's answer, as identical with the number of screen display, be and answer correctly, computer examination 100 is divided into memory achievement (MS), if number of pressing and screen display value differ, then computer repeats display digit once more by the mode and the speed that show for the first time automatically, allow the experimenter answer once more, as correct MS is 90 minutes, as mistake again, then repeat again, by that analogy, every mistake was once detained 10 fens, promptly finished the ability of MS reaction memory automatically until 0 minute, bits per inch is all tested secondary, gets its meansigma methods.
Numeral disappears to the experimenter from screen and answers, and finishes promptly press enter key, between time when making the memory answer react (RT), RT is also together printed together with MS by the computer count recording, RT can reflect and the motion function associated.
More than test is all carried out the own control paired t-test in per front and back same time of every day in stage.
(3) movement response ability
A. simple movement response: calculate subjects's touch potential in 15 seconds
B. monopodia close staring blankly immediately between: it is upright to allow subjects's monopodia close staring blankly, calculates the upright time, about each 3 times, calculate average.
C. compound action reaction: show black, red two kinds of cards to the subjects, allow subjects one see black card, hit table with the right hand as early as possible, see red card, hit table with left hand as early as possible.Calculating show card to the subjects hit the table time, about each 3 times, ask its average.
(4) lab index:
A. oxidation resistance: Serum LPO is measured and use the TBA determination of color, erythrocyte sod vitality test employing fast trace algoscopy.
B. hematid immunity function, RBC-Cab-RR.Ic-R adopts European method to improve slightly.
3, criterion of therapeutical effect:
(1) clinical card marquis criterion of therapeutical effect: produce effects is that cardinal symptom is improved more than the secondary, and objective indicator is recovered normally substantially, and integrated value descends>2/3; Be 1 grade of doing well,improving effectively, objective indicator makes moderate progress, integrated value decline 1/3-2/3; Invalid do not have obvious improvement for cardinal symptom, the objective indicator no change, and integrated value descends<1/3.
(2) cardinal symptom criterion of therapeutical effect: produce effects is doing well,improving secondary or transference cure; Be 1 grade of doing well,improving effectively; Invalid do not have for symptom improve or increase the weight of.
(3) lab index efficacy determination: change difference according to every index before and after the treatment, adopt statistical method, measurement data adopts the t check between group, and enumeration data adopts the X2 check, and ranked data adopt Ridit to analyze.
4. Therapeutic Method: give this Chinese medicine oral liquid of clothes every day three times, each 10ml.One month is a course of treatment.Do not add the Chinese patent medicine of other nourishing spleen kidney during the administration.
5, result:
A. clinical card marquis curative effect: produce effects 51 examples, account for 57.3%, effective 32 examples account for 36.0%; Invalid 6 examples account for 6.7%; Total effective rate 83 examples account for 93.3%.
B. clinical symptoms improvement situation sees the following form:
Symptom example digital display is imitated (%) effectively (%) invalid (%) total effective rate (%)
Loss of appetite 89 49 (55.1) 34 (38.2) 6 (6.7) 83 (93.3)
Soreness of waist and knee joint 89 43 (48.3) 36 (40.2) 10 (11.3) 79 (88.7)
Tired mind 72 43 (59.7) 25 (34.7 4 (5.6) 68 (94.4)
Abdominal distention after meal 69 41 (59.4) 23 (33.3) 5 (7.3) 64 (92.7)
Insomnia and dreamful sleep 75 45 (60.0) 25 (33.3) 5 (6.7) 70 (93.3)
C. the influence to memory ability sees the following form:
3 figure places, 6 figure places, 9 figure places, 12 figure places, 15 figure places
MS preceding 99.2 ± 1.4 96.8 ± 2.1 80.7 ± 7.9 66.7 ± 15 56.5 ± 16
(mark) back 100 ± 0 99.2 ± 1.6 94.6 ± 4.4 78.3 ± 10.9 57.2 ± 18
N=34RT preceding 4.4 ± 2.3 10.6 ± 4.2 14.2 ± 3.8 20.3 ± 7.3 25.2 ± 5.4
(second) back 3.3 ± 1.3 6.9 ± 1.8 12.6 ± 3.8 18.1 ± 5.4 24.7 ± 5.7
As seen from the above table, this Chinese medicine oral liquid can improve the response time (p<0.05) of patient's 3 figure places, 6 figure places, and explanation can improve asthenia of both the spleen and kidney card patient's motion sensitive; Simultaneously, 12 figure place ranges memory degree is obviously improved (p<0.01), reflect that this oral liquid has the effect that improves patient's memory ability.
D. the influence to the movement response ability sees the following form
The example number move merely (inferior/min) compound action (s) close staring blankly immediately between (s)
Control preceding 34 85.25 ± 12.1 0.70 ± 0.15 4.77 ± 1.28
Control back 34 96.24 ± 10.2 0.65 ± 0.21 6.12 ± 2.11
As seen from the above table, this oral liquid extremely significantly improves simple movement response ability (p<0.01), improve simultaneously obviously close staring blankly immediately between (p<0.05).
E. the influence to antioxidant ability of organism sees the following form
Example number LPO (mnol/L) SOD (u/ml)
Treat preceding 34 6.27 ± 1.25 814.32 ± 162.23
Treatment back 34 5.04 ± 1.13 1108.69 ± 182.46
As seen from the above table, this oral liquid not only can significantly improve RBC-C b-RR, can significantly lower RBC-Io-R simultaneously, can reach the effect of antioxidation and radical damage.Show its obviously enhancing body hematid immunity function, help to reduce the patient infection, reach the purpose of slow down aging.
Embodiment:
Embodiment 1.Getting Radix Astragali 6kg, Fructus Lycii 10kg, Semen Euryales 6kg, Rhizoma Atractylodis Macrocephalae 4kg, Semen Nelumbinis 1kg, Radix Codonopsis 2kg, Radix Glycyrrhizae 1kg, Fructus Corni 1kg, Rhizoma Dioscoreae 1kg, Rhizoma Polygonati Odorati 2kg, Fructus Schisandrae Chinensis 2kg, Semen Platycladi 1kg, Radix Salviae Miltiorrhizae 1kg, Arillus Longan 1kg, dried Fructus Vitis viniferae 2kg, Semen sojae atricolor 2kg, Fructus Mume 0.6kg, Poria cum Radix Pini 6kg, Radix Ophiopogonis 1kg, Fructus Mori 6kg decocts with water three times, each 1 hour, collecting decoction is condensed into 1: 1 fluid extract after the filtration; Get Radix Rehmanniae 2kg, Radix Rehmanniae Preparata 1kg, Rhizoma Polygonati 2kg, Radix Polygoni Multiflori 2kg decoct with water three times, each 1 hour, collecting decoction filtered the back with charcoal treatment once, reconcentration becomes 1; 1 fluid extract; Field dobber 2kg adds water and decocts a drug wrapped three times, each 1 hour; Placenta Hominis 2kg adds the water list and fries in shallow oil three times, each half an hour; Merge above-mentioned each extracting solution, add doubling dose 75% ethanol, stir, left standstill 24 hours, filter, filtrate recycling ethanol, concentrated solution stirs evenly with sucrose 10kg, sodium benzoate 0.1kg, filters, and gets oral liquid.Product is henna liquid, and it is sweet to distinguish the flavor of.
Embodiment 2.Getting Radix Astragali 8kg, Fructus Lycii 8kg, Semen Euryales 8kg, Rhizoma Atractylodis Macrocephalae 6kg, Semen Nelumbinis 2kg, Radix Codonopsis 4kg, Radix Glycyrrhizae 2kg, Fructus Corni 2kg, Rhizoma Dioscoreae 2kg, Rhizoma Polygonati Odorati 4kg, Fructus Schisandrae Chinensis 4kg, Semen Platycladi 2kg, Radix Salviae Miltiorrhizae 2kg, Arillus Longan 2kg, dried Fructus Vitis viniferae 4kg, Semen sojae atricolor 4kg, Fructus Mume 0.8kg, Poria cum Radix Pini 8kg, Radix Ophiopogonis 2kg, Fructus Mori 8kg decocts with water three times, each 1 hour, collecting decoction is condensed into 1: 1 fluid extract after the filtration; Get Radix Rehmanniae 4kg, Radix Rehmanniae Preparata 2kg, Rhizoma Polygonati 4kg, Radix Polygoni Multiflori 4kg decoct with water three times, each 1 hour, collecting decoction filtered the back with charcoal treatment once, reconcentration becomes 1: 1 fluid extract; Field dobber 4kg adds water and decocts a drug wrapped three times, each 1 hour; Placenta Hominis 4kg adds the water list and fries in shallow oil three times, each half an hour; Merge above-mentioned each extracting solution, add doubling dose 75% ethanol, stir, left standstill 24 hours, filter, filtrate recycling ethanol, concentrated solution stirs evenly with sucrose 25kg, sodium benzoate 0.4kg, filters, and gets oral liquid.Product is henna liquid, and it is sweet to distinguish the flavor of.
Embodiment 3.Get Radix Astragali 10kg, Fructus Lycii 6kg, Semen Euryales 10kg, Rhizoma Atractylodis Macrocephalae 8kg, Semen Nelumbinis 3kg, Radix Codonopsis 6kg, Radix Glycyrrhizae 3kg, Fructus Corni 3kg, Rhizoma Dioscoreae 3kg, Rhizoma Polygonati Odorati 6kg, Fructus Schisandrae Chinensis 6kg, Semen Platycladi 3kg, Radix Salviae Miltiorrhizae 3kg, Arillus Longan 3kg, dried Fructus Vitis viniferae 6kg, Semen sojae atricolor 6kg, Fructus Mume 1.0kg, Poria cum Radix Pini 10kg, Radix Ophiopogonis 3kg, Fructus Mori 10kg, Radix Rehmanniae 6kg, Radix Rehmanniae Preparata 3kg, Rhizoma Polygonati 6kg, Radix Polygoni Multiflori 6kg, field dobber 6kg, Placenta Hominis 6kg decocts with water three times, be respectively 3 at every turn, 2,1 hour, place precipitation, filter, filtrate merges, be concentrated into relative density and be 1.28 clear paste, add sugar refinery and make unguentum.

Claims (3)

1, the Chinese medicine of nourishing the liver and kidney, strengthening spleen and nourishing blood, mind tranquilizing and the heart calming, loosening bowel to relieve constipation is characterized in that its composition and effectiveness and percentage by weight thereof:
Radix Astragali 6-10 Rhizoma Atractylodis Macrocephalae 4-8 Fructus Lycii 6-10 Radix Rehmanniae 2-6
Fructus Mori Poria cum Radix Pini 6-10 6-10 Semen Cuscutae 2-6 Semen Euryales 6-10
Radix Ophiopogonis 1-3 Radix Codonopsis 2-6 Radix Rehmanniae Preparata 1-3 Semen Nelumbinis 1-3
Rhizoma Polygonati 2-6 Radix Glycyrrhizae 1-3 Fructus Corni 1-3 Radix Polygoni Multiflori 2-6
Rhizoma Dioscoreae 1-3 Rhizoma Polygonati Odorati 2-6 Fructus Schisandrae Chinensis 2-6 Semen Platycladi 1-3
Radix Salviae Miltiorrhizae 1-3 Placenta Hominis 2-6 Arillus Longan 1-3 dried Fructus Vitis viniferae 2-6
Semen sojae atricolor 2-6 Fructus Mume 0.6-1.0
2, the manufacture method of the Chinese medicine oral liquid of nourishing the liver and kidney, strengthening spleen and nourishing blood, mind tranquilizing and the heart calming, loosening bowel to relieve constipation, it is characterized in that: 20 flavors such as the Radix Astragali, Fructus Lycii, Semen Euryales, the Rhizoma Atractylodis Macrocephalae, Semen Nelumbinis, Radix Codonopsis, Radix Glycyrrhizae, Fructus Corni, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, Semen Platycladi, Radix Salviae Miltiorrhizae, Arillus Longan, dried Fructus Vitis viniferae, Semen sojae atricolor, Fructus Mume, Poria cum Radix Pini, Radix Ophiopogonis, Fructus Mori are decocted with water three times, each 1 hour, collecting decoction is condensed into fluid extract after the filtration; Four flavors such as Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Polygoni Multiflori are decocted with water three times, and each 1 hour, collecting decoction filtered the back with charcoal treatment once, and reconcentration becomes fluid extract; Semen Cuscutae adds water decocts a drug wrapped each 1 hour three times; Placenta Hominis adds the water list fries in shallow oil each 0.5 hour three times; Merge above-mentioned each extracting solution, add doubling dose 75% ethanol, stir, left standstill 24 hours, filter, filtrate recycling ethanol, concentrated solution stirs evenly with sucrose, sodium benzoate, filters, and adds water to ormal weight, leaves standstill 48 hours, filters, promptly.
3, nourishing the liver and kidney, strengthening spleen and nourishing blood, mind tranquilizing and the heart calming, the Chinese medicine unguentum manufacture method of loosening bowel to relieve constipation, it is characterized in that: with the Radix Astragali, Fructus Lycii, Semen Euryales, the Rhizoma Atractylodis Macrocephalae, Semen Nelumbinis, Radix Codonopsis, Radix Glycyrrhizae, Fructus Corni, Rhizoma Dioscoreae, Rhizoma Polygonati Odorati, Fructus Schisandrae Chinensis, Semen Platycladi, Radix Salviae Miltiorrhizae, Arillus Longan, dried Fructus Vitis viniferae, Semen sojae atricolor, Fructus Mume, Poria cum Radix Pini, Radix Ophiopogonis, Fructus Mori, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Polygoni Multiflori, Semen Cuscutae and Placenta Hominis 20 Six-element medical materials decoct with water three times, be respectively 3 at every turn, 2,1 hour, place precipitation, filter, filtrate merges, be concentrated into relative density and be 1.28 clear paste, add sugar refinery and make.
CNB031323189A 2003-08-11 2003-08-11 Chinese medicine for invigorating liver, kidney and spleen, nourishing blood, tranquilizing mind relaxing bowels and the prepn process of the Chinese medicine prepn Expired - Fee Related CN1219543C (en)

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