CN1280835A - Chinese-medicinal capsule for treating hyperlipomia - Google Patents
Chinese-medicinal capsule for treating hyperlipomia Download PDFInfo
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- CN1280835A CN1280835A CN 00107136 CN00107136A CN1280835A CN 1280835 A CN1280835 A CN 1280835A CN 00107136 CN00107136 CN 00107136 CN 00107136 A CN00107136 A CN 00107136A CN 1280835 A CN1280835 A CN 1280835A
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Abstract
A Chinese medicine in the form of capsules for treating hyperlipomia is prepared through extracting astragalus root, red sage root and fleece flower root in alcohol to obtain extract, decocting their dregs with 8 other Chinese-medicinal materials such as maythorn, Chuanxiong, sophor Flower-bud, Job's tears, etc. filtering, concentrating to obtain another extract, mixing the above both extracts with powdered notoginseng and leech, baking, pulverizing, loading in capsules and sterilization. Its advantages include high curative effect and total effective rate up to 95% or more, short course of treatment, and no toxic by-effect.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of hyperlipemia, particularly relating to a kind of is the Chinese medicinal capsule preparation that is used for the treatment of hyperlipemia that raw material is made with Chinese medicine.
Hyperlipemia is commonly encountered diseases, the frequently-occurring disease of present middle-aged and elderly people, by the cardiovascular and cerebrovascular disease due to the hyperlipemia is one of disease kind that mortality rate is the highest in the world, and sickness rate is the trend that rises year by year, harm to human health is increasing, has become one of key factor of cardiovascular and cerebrovascular disease generation.Therefore, how to prevent and treat hyperlipemia and become the problem that medical circle presses for solution.At present the Chinese and western drugs of this class disease of treatment is more, the Western medicine effect for reducing fat still can, but late result is not good, and side effect is bigger; How the Chinese medicine fat-reducing medicament controls angle from dialectical opinion is started with, and has but ignored the basic reason that causes lipid to raise, or does not consider to cause a series of pathological changes that cause because of lipid is too high.
The objective of the invention is to provide a kind of Chinese medicinal capsule preparation that is used for the treatment of hyperlipemia that can regulate the organism endocrine function, correct lipid metabolic disorder, blood circulation promoting at above deficiency.
It is considered herein that this disease mainly is because the body lipid metabolism disorder, and then cause lipid compositions such as cholesterolemia, triglyceride to be higher than normally, it and hypertension, diabetes, coronary heart disease, arteriosclerosis etc. substantial connection arranged.Modern medicine study thinks that accumulating, increasing of blood fat is the key factor that arteriosclerosis forms.Therefore, the control hyperlipemia also is one of important channel that prevents arteriosclerosis and cardiovascular and cerebrovascular disease.Therapeutic Principle of the present invention is " an activating the spleen kidney tonifying; the blood stasis dispelling of eliminating the phlegm ", adopt strengthening spleen, tonifying kidney, promoting blood circulation to remove obstruction in the collateral, vessel softening, dampness removing reduces phlegm, and in conjunction with promoting that lipid transforms metabolic method, developed the Chinese medicinal capsule preparation of treatment hyperlipemia, this capsule is that the component with following proportioning by weight is the medicament that raw material is made:
The Radix Astragali 15～30g Radix Polygoni Multiflori 10～20g Fructus Crataegi 15～30g Radix Notoginseng 10～15g
Radix Salviae Miltiorrhizae 15～30g Hirudo 5～10g Rhizoma Chuanxiong 10～20g Flos Sophorae Immaturus 15～30g
Semen Coicis 15～30g Folium Nelumbinis 10～20g Rhizoma Alismatis 15～30g Herba Taxilli 15～30g
Radix Glycyrrhizae 5～10g
Preparation method is, with 70% ethanol extraction, backflow ethanol is made pure extractum with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori; Above three flavor medicinal residues and Fructus Crataegi, Rhizoma Chuanxiong, the Flos Sophorae Immaturus, Semen Coicis, Folium Nelumbinis, Rhizoma Alismatis, Herba Taxilli, Radix Glycyrrhizae decocting are extracted twice, each 1 hour, merge decocting liquid twice, filter, concentrate and make the water extracted immersing paste; With the dry fine powder mixing of above-mentioned two kinds of extractum and Radix Notoginseng, Hirudo, oven dry is pulverized again, divides encapsulatedly, sterilizes.
The present invention selects for use the Radix Astragali, Radix Polygoni Multiflori, Fructus Crataegi to be monarch, Radix Astragali replenishing QI to invigorate the spleen wherein, blood pressure lowering coronary dilating, blood fat reducing, enhancing human body immunity power, Radix Polygoni Multiflori invigorating the liver and kidney, benefiting essence-blood, has vessel softening, strengthen blood vessel elasticity, reduce the absorption of cholesterol, triglyceride reducing at enteral, play the effect that improves cerebral circulation, the hawthorn digesting eliminate indigestion, blood circulation promoting and blood stasis dispelling, activating spleen and strengthening stomach; Be aided with Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Hirudo promoting blood circulation to remove obstruction in the collateral, regulate the flow of vital energy, Radix Notoginseng and Radix Salviae Miltiorrhizae, Fructus Crataegi are share has blood viscosity lowering, reduce TC and TG, improve the effect of blood circulation, the expectorant of Semen Coicis invigorating spleen for diuresis, the cool liver and clearing heat removing dampness of the Flos Sophorae Immaturus: assistant is eliminated the phlegm with Folium Nelumbinis, Rhizoma Alismatis, Herba Taxilli the kidney invigorating dampness removing: make with the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, reach triglyceride reducing, cholesterol jointly, high density lipoprotein increasing, blood viscosity lowering, vessel softening, the effect of blood circulation promoting.
Further describe the present invention below in conjunction with embodiment:
According to the Chinese medicinal capsule preparation of the present invention preparation, its most preferred embodiment is that the component with following proportioning by weight is the medicament that raw material is made:
Radix Astragali 20g Radix Polygoni Multiflori 15g Fructus Crataegi 20g Radix Notoginseng 10g Radix Salviae Miltiorrhizae 20g
Hirudo 8g Rhizoma Chuanxiong 15g Flos Sophorae Immaturus 15g Semen Coicis 20g Folium Nelumbinis 15g
Rhizoma Alismatis 15g Herba Taxilli 15g Radix Glycyrrhizae 8g
The present invention is from nineteen ninety to 1994 year treatment hyperlipemia 115 examples, and does contrast with clofibrate group 50 examples.The capsule preparations that the treatment group is taken is according to prescription of the present invention, requires processing by the Xinzhou pharmaceutical factory of traditional Chinese medicine according to provisions for new drugs approval Chinese medicine production technology and quality standard, and the tentatively titled blood fat reducing reaches recovering capsule.Every day 3 times, each 4 (every contain concentrate medicine 0.4g, be equivalent to crude drug 5g): matched group is taken peace holder ' Yanming ' capsules for clearing (being produced by the BJ Pharmaceutical Co., Ltd.) every day 3 times, each 1 (every 0.58).Two groups all with single blind method administration, is 1 course of treatment to take medicine 1 month, does the contrast observation after treat two courses of treatment.Observed result treatment group clinic control rate and total effective rate reach 58.3%, 95.7% respectively, and matched group then is respectively 46%, 76%, learn check by statistics, and group there is significant difference P＜0.05, two.Confirm that this product is better than contrasting the medicine clofibrate in curative effect aspect the treatment hyperlipemia, and can significantly improve the patient since due to the blood fat, hyperpiesia dizzy, breathe hard, symptoms such as uncomfortable in chest, cardiopalmus, numb limbs and tense tendons, thirsty frequent micturition, spiritlessness and weakness.
Confirm that through zoopery the present invention can significantly reduce the blood lipid level of hyperlipemia animal, improves blood viscosity and hemorheological property.Acute toxinology experiment confirms that also this product takes no obvious toxic and side effects for a long time, and is safe and reliable.
In sum, the present invention is evident in efficacy, and short treating period has no side effect, the energy treating both the principal and secondary aspects of a disease, and clinical total effective rate reaches more than 95%, is better than present similar medicine, is expected to become the good medicine of preventing and treating hyperlipemia, cardio-cerebrovascular disorder, is suitable for middle-aged and elderly people and takes for a long time.Preparation technology of the present invention is scientific and reasonable, adopts alcohol, water extraction method, and it is fried to have avoided simple employing water extraction that water-fast effective ingredient is difficult to, the deficiency that volatile ingredient is easily lost, and take very convenient to carryly, have potential application and exploitation is worth.
Claims (3)
1, a kind of Chinese medicinal capsule preparation for the treatment of hyperlipemia is characterized in that it is that component with following proportioning by weight is the medicament that raw material is made:
The Radix Astragali 15～30g Radix Polygoni Multiflori 10～20g Fructus Crataegi 15～30g Radix Notoginseng 10～15g
Radix Salviae Miltiorrhizae 15～30g Hirudo 5～10g Rhizoma Chuanxiong 10～20g Flos Sophorae Immaturus 15～30g
Semen Coicis 15～30g Folium Nelumbinis 10～20g Rhizoma Alismatis 15～30g Herba Taxilli 15～30g
Radix Glycyrrhizae 5～10g
2, the Chinese medicinal capsule preparation of treatment hyperlipemia according to claim 1 is characterized in that it is that component with following proportioning by weight is the medicament that raw material is made:
Radix Astragali 20g Radix Polygoni Multiflori 15g Fructus Crataegi 20g Radix Notoginseng 10g Radix Salviae Miltiorrhizae 20g
Hirudo 8g Rhizoma Chuanxiong 15g Flos Sophorae Immaturus 15g Semen Coicis 20g Folium Nelumbinis 15g
Rhizoma Alismatis 15g Herba Taxilli 15g Radix Glycyrrhizae 8g
3, the Chinese medicinal capsule preparation of treatment hyperlipemia according to claim 1 is characterized in that preparation method is: with 70% ethanol extraction, backflow ethanol is made pure extractum with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori; Above three flavor medicinal residues and Fructus Crataegi, Rhizoma Chuanxiong, the Flos Sophorae Immaturus, Semen Coicis, Folium Nelumbinis, Rhizoma Alismatis, Herba Taxilli, Radix Glycyrrhizae decocting are extracted twice, each 1 hour, merge decocting liquid twice, filter, concentrate and make the water extracted immersing paste; With the dry fine powder mixing of above-mentioned two kinds of extractum and Radix Notoginseng, Hirudo, oven dry is pulverized again, divides encapsulatedly, sterilizes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107136 CN1101199C (en) | 2000-04-21 | 2000-04-21 | Chinese-medicinal capsule for treating hyperlipomia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107136 CN1101199C (en) | 2000-04-21 | 2000-04-21 | Chinese-medicinal capsule for treating hyperlipomia |
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| Publication Number | Publication Date |
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| CN1280835A true CN1280835A (en) | 2001-01-24 |
| CN1101199C CN1101199C (en) | 2003-02-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 00107136 Expired - Fee Related CN1101199C (en) | 2000-04-21 | 2000-04-21 | Chinese-medicinal capsule for treating hyperlipomia |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485865B (en) * | 2009-02-11 | 2011-06-29 | 白云沂 | Chinese medicine fat-reducing plaster |
| CN102935152A (en) * | 2012-12-08 | 2013-02-20 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating hyperlipidaemia as well as preparation method and application thereof |
| CN103007100A (en) * | 2013-01-14 | 2013-04-03 | 广东一方制药有限公司 | Composition with functions of body slimming and waistline reduction and preparation method of composition |
| CN104547625A (en) * | 2015-02-09 | 2015-04-29 | 王士国 | Preparation with effects of promoting digestion and reducing lipid and preparation method |
| CN105998919A (en) * | 2016-07-22 | 2016-10-12 | 龙燕妮 | Traditional Chinese medicine for treating hyperlipidemia |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100393247C (en) * | 2005-05-25 | 2008-06-11 | 邵建国 | Lipid-lowering beverage and preparation method thereof |
-
2000
- 2000-04-21 CN CN 00107136 patent/CN1101199C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485865B (en) * | 2009-02-11 | 2011-06-29 | 白云沂 | Chinese medicine fat-reducing plaster |
| CN102935152A (en) * | 2012-12-08 | 2013-02-20 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating hyperlipidaemia as well as preparation method and application thereof |
| CN102935152B (en) * | 2012-12-08 | 2014-08-20 | 滨州医学院烟台附属医院 | Traditional Chinese medicine composition for treating hyperlipidaemia as well as preparation method and application thereof |
| CN103007100A (en) * | 2013-01-14 | 2013-04-03 | 广东一方制药有限公司 | Composition with functions of body slimming and waistline reduction and preparation method of composition |
| CN104547625A (en) * | 2015-02-09 | 2015-04-29 | 王士国 | Preparation with effects of promoting digestion and reducing lipid and preparation method |
| CN105998919A (en) * | 2016-07-22 | 2016-10-12 | 龙燕妮 | Traditional Chinese medicine for treating hyperlipidemia |
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| Publication number | Publication date |
|---|---|
| CN1101199C (en) | 2003-02-12 |
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