CN102114066B - Medicinal composition for alleviating physical fatigue - Google Patents
Medicinal composition for alleviating physical fatigue Download PDFInfo
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- CN102114066B CN102114066B CN2011100455662A CN201110045566A CN102114066B CN 102114066 B CN102114066 B CN 102114066B CN 2011100455662 A CN2011100455662 A CN 2011100455662A CN 201110045566 A CN201110045566 A CN 201110045566A CN 102114066 B CN102114066 B CN 102114066B
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- radix rhodiolae
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- taurine
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Abstract
The invention relates to a medical configuration product, in particular to a medicinal composition for alleviating physical fatigue. The composition comprises 0.1 to 0.3 part of forest frog oviduct, 1 to 5 parts of rhodiola rosea extract, 0.1 to 0.5 part of taurine, 0.01 to 0.05 part of vitamin B1, and 0.01 to 0.05 part of vitamin B6. The composition can alleviate physical fatigue, is suitable for sportspeople, mental workers and travelers, and is particularly suitable to be drunk by highland travelers.
Description
Technical field
The present invention relates to a kind of medical configuration article, be specifically related to a kind of pharmaceutical composition of alleviating physical fatigue.
Background technology
Add up to 25,000,000,000 yuan according to the domestic health-product market consumption scale of relevant report; Getting rid of other factors; Only consider to receive under the prerequisite that income factor influences; If individual average year is taken in the speed increase according to 5% in 5 years from now on, expect 2010, national health product consumption scale will reach 50,000,000,000 yuan.And smart wound is thirsty tired or feel that for a long time the crowd who feels exhausted has occupied about 15% the market share basically after the high strength physical training, physical work.
And such functional product is also fewer at present; Mainly be to wait indirect fatigue alleviating with other nutrient through replenishing some trace element; And these article adopt natural drug and some trace element to form with other nutrient compatibility; Be without any side effects, effect is remarkable, fatigue alleviating obvious results health preparation.
The Oviductus Ranae function cures mainly and is the kidney invigorating and essence nourishing, nourishing YIN and moistening the lung, and it is weak to be used for the deficiency of YIN, spiritlessness and weakness, palpitation and insomnia, night sweat is more than, the consumptive disease hemoptysis of coughing, this medicine of usefulness among the people is as the tonic of nourishing kidney-YIN.Radix Rhodiolae function heat-clearing and toxic substances removing is controlled throat pain, and pain in the lung is regulated the flow of vital energy, and controls throat pain, pain in the lung; The kidney invigorating arranged, nourish heart, calm the nerves, regulating menstruation and activating blood, the effectiveness that makes eye bright.Be used for resisting fatigue, defying age and aspects such as raising mentality and physical function.
Radix Rhodiolae, property is put down sweet in the mouth, has air making-up and spleen enlivening, and the effect of blood circulation promoting and blood stasis dispelling has anti-hypoxia, resisting fatigue, defying age, antiviral, resisting microwave radiation, nervous system regulation, cardio-cerebrovascular and immunity.Radix Rhodiolae can improve mice swimming endurance time and transfer rod endurance time, reduces degree of fatigue, strengthens central nervous system's function.Saponins compound in the Radix Rhodiolae (rhodioside) is the effective ingredient of its resisting kinetic fatigue effect, possibly influence the rat lipid metabolism and improve exercise tolerance.The antifatigue effect of rhodioloside and its enhancing activities of antioxidant enzymes; Alleviate long-time endurance exercise and produce radical pair skeletal muscle and induced myocardial injury; Amino acid metabolism and raising one oxidation synthase (NOS) activity in the influence tissue; Slow down the NO content of organizing that prolonged exercise causes and descend, influence mice sugar, fat and amino acid metabolism and strengthen aerobic capacity etc. and act on relevant.
Taurine is claimed 2-aminoethyl sulfonic acid again, belongs to non essential amino acid, and is relevant to synthetic cysteine in the body, and can promote biliary secretion and absorption.Help perfect, the absorption of calcium and the digesting and assimilating of lipid material of brain development, nerve conduction, visual skill to the baby.To brain overwork, motion and work overwork person ability allaying tiredness; Keep the normal physiological function of brain, promote the growth of infant brain; Keep and look function normally; Antioxidation, delaying senility function; The promotion human body is digested and assimilated lipid material, and participates in the metabolism of bile salt; Improve immunocompetence.Can improve T cell and lymphocytic multiplication capacity; Taurine is participated in the endocrine activity, and cardiovascular system is had a series of unique effect.Can strengthen left ventricular function, strengthen ventricular systole power, anti-mental and physical efforts are not normal, prevent congestive heart failure and bring high blood pressure down.According to another report, taurine can also prevent stasis in fat and the bile liver; The expansion bile duct promotes bile secretion; Can in and cytotoxin, reduce the toxicity of secondary acid, the protection liver plasma membrane.Therefore, it has good function of gallbladder promoting, protects the liver and Detoxication; Can promote acute hepatitis to recover normal; Carbon tetrachloride poisoning there is protective effect, and suppresses the rising of caused serum glutamic pyruvic transminase thus.In addition, taurine can also be participated in insulin and must secrete as osmotic pressure regulator, blood sugar lowering, and the expansion blood capillary can be treated intermittent claudication, can also promote A Si medicine such as pouring in gastral absorption.
Vitamin B1 extensively is present in the plant, and content is abundant in the kind skin of frumentum, beans, and especially content is higher in yeast; The metabolism of vitamin B1 and ribose is closely related; When Vitamin B1 deficiency, the metabolism of sugar is obstructed, the acetone acid accumulation; Make that acetone acid content increases in blood, urine and the cerebral tissue, symptoms such as multiple row neuritis, amyotrophy, edema of lower limbs occur.Vitamin B1 is kept the effect of normal digestive gland secretion and gastrointestinal peristalsis in addition in addition.Therefore the physiological function of vitamin B1 is mainly and prevents that multiple peripheral nerve is scorching, promotes growth, increases the tonicity of appetite and gastrointestinal, keeps the normal heart function.
Vitamin B2 is riboflavin again, extensively is present in animal.In the plant, content is abundant in fervent, the yeast of rice, liver, the egg yolk.Can be short through sugar, fat, proteic metabolism.Normal function to keeping skin, mucosa and vision all has certain effect.When Vitamin B2 deficiency, symptoms such as angular cheilitis, glossitis, conjunctivitis, dryness dermatitis and the dimness of vision, Tissue respiration alkali are weak, the reduction of metabolism intensity can appear.
Vitamin B6 is claimed adermin again, and it is very wide in animals and plants, to distribute, and frumentum crust content is especially abundant.The symptom such as produced vomiting, central nervous excitation, the special dermatitis-erythroderma of limbs of B6 is deficient in vitamin.Be used to treat shameless disease clinically, because of drug-induced neuritis, leukopenia and acne, seborrheic eczemas etc. such as feeling sick of causing of radiotherapy, vomiting during pregnancy, isoniazid and benzene pyridazines.In addition, vitamin B6 also has relation to the generation of cardiovascular disease.
In carbohydrate metabolism, participate in the decarboxylic reaction of acetone acid or a-ketoglutaric acid as the vitamin B1 of pyruvic carboxylase coenzyme.If body lacks vitamin B1, the acetone acid metabolism is obstructed, and influences some amino acid whose transaminations, destroy the body nitrogen balance.Have data to show, the metabolism of body moisture and salt also can take place not normally when being deficient in vitamin B1, and these all directly influence the mobility of body.The active prothetic group that is formed by vitamin B2 is generally flavin purine dinucleotide or FMN; They can form various flavoproteins with the plurality of enzymes protein binding; And, participate in the oxidation-reduction process of the complicacy of body as an important component part of electron transfer system.It is thus clear that, be to produce feeling of fatigue owing to can not get competent energy in the activity of body if the body B2 that is deficient in vitamin will directly influence the oxidation energy supplying system.Vitamin B6 is transaminase's a coenzyme, and its shortage will influence proteinic vigor.Also have some vitamin can directly participate in the metabolism that promotes alive, be easy to oxidation like vitamin C, in redox system, the hydrogen effect is passed in performance.Therefore vitamin C can oxidation reinforcedization reduction process, improves the ability to take oxygen of tissue, the metabolism battalion oxygen function of tissue is strengthened, thereby the endurance of enhancing body makes it to be not easy to produce tired sensation.
The muscle power fatigue is claimed mobility or muscle contraction fatigue again.The people is carrying out heavy physical labour, large amount of exercise exercise, since overlong time, the muscle hypertonicity, and bioenergy consumption is too much, will make body produce feeling of fatigue.Because the complex genesis of physical fatigue, medical circles still do not have clearly classification at present, and it also is varied therefore nursing one's health tired product, wherein, can replenish some nutrients such as taurine, vitamin B1, vitamin B6; Tcm product also has the kidney invigorating product etc. except that " Radix Astragali essenc oral liquid ", " Oral Liquid Radix Panacis Quinquefolii " and common kinds such as " people's raw royal jellies ".
In addition; The patent application that relates to alleviating physical fatigue among the Chinese patent data base reaches 69; Involved Chinese medicine has tens of kinds more than in Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii, Radix Panacis Quinquefolii, Radix Rhodiolae, Cordyceps, Lac regis apis, Fructus Lycii, Cornu Cervi Pantotrichum etc., and involved chemicals has taurine, vitamin C, vitamin B1, vitamin B6.The representative person that wherein fills a prescription has two; The first; Publication number is the described edible health care product technical field that the present invention relates to of CN200510111887.2 application for a patent for invention, particularly relates to a kind of edible health care product with auxiliary improving memory function and alleviating physical fatigue function.Proportioning according to composition by weight is: soybean phospholipid 5-50 part; Radix Puerariae extract 5-50 part; Semen Vitis viniferae extract 2-25 part; Radix Paeoniae Alba extract 2-25 part; Taurine 2-25 part; Theanine extract 2-25 part.This invention can be used for the symptom that memory function that the relieve chronic fatigue syndrome brought descends, alleviating physical fatigue.It two is; Publication number is the described preparation of the application for a patent for invention of CN200510014724.2; A kind of health food that can improve human body physical agility, endurance is processed according to following weight proportion by following raw materials according: 0.01～1 part in 20～100 parts of ferrous porphyrins, 100～500 parts in Colla Corii Asini, 100～500 parts of Herba Epimedii extracts, 50～100 parts of Radix Rhodiolae extracts, VB15～100 part, VB60.1～2 part, folic acid.Advantage of the present invention is: have alleviating physical fatigue and the effect that improves iron deficiency anemia; The crowd that it is suitable for comprises the physical fatigue and the crowd of iron deficiency anemia that causes because of various factors, and especially hemorrhagic anemia and the fatigue to the athlete of high strength, highdensity training and match and heavy physical labourer one mistake property is more suitable.Weary to the hemogram abnormity and the Mental fatigue power of putting, chemotherapy causes, loss of appetite, the cancer patient that body's immunity descends also can be used as auxiliary health food.But above-mentioned two kinds of prescriptions and prescription of the present invention have than big difference, nor are to be specifically designed to alleviating physical fatigue.
But because the complex genesis of physical fatigue, its mechanism is a lot of with conditioning mechanism at present, so need bring into play the advantage of Chinese medicine and related substance, develops the health-care products of too many levels, multi-level, many target spots.
Summary of the invention
The technical problem that the present invention will solve provides a kind of compositions with effect of relieving physical fatigue.
The technical scheme that the present invention solves the problems of the technologies described above is:
A kind of pharmaceutical composition of alleviating physical fatigue, said composition is made up of the raw material of following weight parts: Oviductus Ranae 0.1～0.3, Radix Rhodiolae water extract 1～5, taurine 0.1～0.5, vitaminB10 .01～0.05, vitamin B6 0.01～0.05.
In the such scheme, described Radix Rhodiolae water extract is carried the extract that obtains by Chinese crude drug Radix Rhodiolae water, and its method for distilling can be traditional method, and the method that the present invention recommends is described below:
Get Radix Rhodiolae decocte with water twice, add for the first time and decoct 2.0h after 10 times of amounts of water are soaked 0.5h, add 8 times of amounts of water for the second time; Decoct 1.0h; Filter, it is centrifugal with the 16000rpm tubular type to filtrate, and it is 1.30～1.35 thick paste that centrifugal liquid is concentrated into 60 ℃ of following relative densities; Then temperature be 60 ℃ with condition vacuum drying or the spray drying of vacuum for-0.08Mpa, extract powder.
Preparation of drug combination method according to the invention is; Get the Radix Rhodiolae water extract; Add Oviductus Ranae fine powder, taurine, vitamin B1 and vitamin B6 mixing, process various common solid orally ingestibles by common process then, like granule, tablet or capsule.
Pharmaceutical composition of the present invention, wherein is the best proportioning of each raw material an Oviductus Ranae 0.2, the Radix Rhodiolae water extract?, taurine 0.2, vitaminB10 .02, vitamin B6 0.02.
Pharmaceutical composition of the present invention cooperates supplementary to be prepared from natural material, finds that through the experiment of mice being carried out anti-stress these article have resisting fatigue; Make the fast quick-recovery physical ability of body, the effect of raising anoxia enduring etc., without any side effects; Be fit to the motion personage; The brain worker, the tourism personage, particularly highland tour personage drinks.
To prove the effect that the present invention has through experiment below.
This experiment is according to anti-stress experiment commonly used, and the tired hungry mice of having taken pharmaceutical composition of the present invention is observed.Main experiment is: anoxia enduring experiment, resisting fatigue experiment, high temperature resistant experiment.
The research of mouse anti stress
1 reagent and material
1.1 experimental subject: Kunming kind aged mouse (10 monthly age), body weight 45～55g, female.
1.2 given the test agent:
Given the test agent 1: be the granule of following embodiment 1.
Given the test agent 2: be the tablet of following embodiment 2.
Given the test agent 3: be the capsule of following embodiment 3.
1.3 divide into groups and administration
Be divided into 6 groups at random, 12 every group, it is respectively 1,2,3 groups of blank group (normal group) and given the test agent.Above-mentioned press respectively human dosage convert (adopts general dosage conversion method, specifically referring to Qi Chen. the herbal pharmacology research methodology. Beijing: People's Health Publisher [M] .2006:116) irritate the stomach use for mice adds the suitable quantity of water dissolving with dosage.Each treated animal is freely drunk the 0.1%BSA acidifying water in experimentation, blank control group is irritated the clothes normal saline every day, irritates the clothes given the test agent respectively for other 3 groups, every day 1 time, continuous 4 weeks.
2 methods and result
2.1 to the hungry 16h before the last administration that influences of mice normobaric hypoxia endurance, 1h puts into the 250ml wide mouthed bottle that fills the 10g sodica calx with mice after the last administration, adds a cover the vaseline sealing, record mice life span.The result sees the following form 1.
2.2 to the hungry 24h before the last administration that influences of mouse anti-reflecting fatigue effect, 1h puts into 27 ± 2 ℃ of ponds with mice after the last administration, the record mice is life span (entry of record mice sinks under the water to mouth and nose and reaches the above time of 10s) in water.The result sees the following form 1.
2.3 1h puts into 75 ± 1 ℃ of calorstats with mice after the administration of high temperature resistant test last, the record life span.The result sees the following form 1.
Table 1 anti-stress result of the test table (n=10)
* P＜0.05, blank group and each group are relatively; #P＜0.05, given the test agent and given the test agent 1 are relatively.
The result shows in three indexs such as anti-hypoxia, resisting fatigue, high temperature resistance, between blank group and each group significant difference is arranged, and explains that said composition can increase aged mouse anoxia enduring, endurance, resistant to elevated temperatures time-to-live.
Between the given the test agent, resisting fatigue index given the test agent 1 and given the test agent 2, significant difference is arranged between 3, see that from three index values given the test agent 2,3 all is superior to given the test agent 1, and given the test agent 2, do not have difference between 3.
The specific embodiment
Example 1
1, preparation Radix Rhodiolae water extract:
Get Radix Rhodiolae decocte with water twice, add for the first time and decoct 2.0h after 10 times of amounts of water are soaked 0.5h, add 8 times of amounts of water for the second time; Decoct 1.0h; Filter, it is centrifugal with the 16000rpm tubular type to filtrate, and it is 1.30～1.35 thick paste that centrifugal liquid is concentrated into 60 ℃ of following relative densities; Then temperature be 60 ℃ with condition vacuum drying or the spray drying of vacuum for-0.08Mpa, extract powder.(the simplest traditional water extracting method is provided)
2, preparation capsule:
Get prepared Radix Rhodiolae extract powder 0.4g, add Oviductus Ranae fine powder 0.1g, taurine 0.1g, vitamin B1 0.01g and vitamin B6 0.01g, mixing; The pregelatinized Starch that adds suitable gross weight 10%, mixing is used 80% alcohol granulation; Drying, encapsulated, promptly be prepared into capsule.
3, instructions of taking: oral, one time 2,2 times on the one.
Example 2
1, preparation Radix Rhodiolae water extract:
Get Radix Rhodiolae decocte with water twice, add for the first time and decoct 2.0h after 10 times of amounts of water are soaked 0.5h, add 8 times of amounts of water for the second time; Decoct 1.0h; Filter, it is centrifugal with the 16000rpm tubular type to filtrate, and it is 1.30～1.35 thick paste that centrifugal liquid is concentrated into 60 ℃ of following relative densities; Then temperature be 60 ℃ with condition vacuum drying or the spray drying of vacuum for-0.08Mpa, extract powder.
2, preparation tablet:
Get prepared Radix Rhodiolae extract powder 0.6g, add Oviductus Ranae fine powder 0.2g, taurine 0.2g, vitamin B1 0.02g and vitamin B6 0.02g, mixing; The pregelatinized Starch that adds suitable gross weight 10%, mixing is used 80% alcohol granulation; Drying adds the magnesium stearate mixing that makes particle weight 0.5%, tabletting again; The bag film-coat promptly is prepared into tablet.
3, instructions of taking: oral, one time 2,2 times on the one.
Example 3
1, preparation Radix Rhodiolae water extract:
This routine method for preparing is identical with example 2 said methods.
2, preparation granule
Get prepared Radix Rhodiolae extract powder 0.8g, add Oviductus Ranae fine powder 0.3g, taurine 0.5g, vitamin B1 0.05g and vitamin B6 0.05g, mixing; Add the dextrin of suitable gross weight 10%, 30% Icing Sugar; Mixing is used 80% alcohol granulation, drying; Pack (5g/ bag) promptly is prepared into granule.
3, instructions of taking: oral, a 5g, 2 times on the one.
Claims (3)
1. the pharmaceutical composition of an alleviating physical fatigue, said composition is made up of the raw material of following weight parts: Oviductus Ranae 0.1～0.3, Radix Rhodiolae water extract 1～5, taurine 0.1～0.5, vitaminB10 .01～0.05, vitamin B6 0.01～0.05.
2. compositions according to claim 1 is characterized in that the weight portion proportioning of described raw material is: Oviductus Ranae 0.2, Radix Rhodiolae water extract 3, taurine 0.2, vitaminB10 .02, vitamin B6 0.02.
3. compositions according to claim 1 and 2 is characterized in that described Radix Rhodiolae water extract is prepared by following method:
Get Radix Rhodiolae decocte with water twice, add for the first time and decoct 2.0h after 10 times of amounts of water are soaked 0.5h, add 8 times of amounts of water for the second time; Decoct 1.0h; Filter, it is centrifugal with the 16000rpm tubular type to filtrate, and it is 1.30～1.35 thick paste that centrifugal liquid is concentrated into 60 ℃ of following relative densities; Then temperature be 60 ℃ with condition vacuum drying or the spray drying of vacuum for-0.08Mpa, extract powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011100455662A CN102114066B (en) | 2011-02-25 | 2011-02-25 | Medicinal composition for alleviating physical fatigue |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011100455662A CN102114066B (en) | 2011-02-25 | 2011-02-25 | Medicinal composition for alleviating physical fatigue |
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| CN102114066A CN102114066A (en) | 2011-07-06 |
| CN102114066B true CN102114066B (en) | 2012-04-18 |
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| CN104000181A (en) * | 2013-02-27 | 2014-08-27 | 北京宝德润生医药科技发展有限公司 | Composition for relieving physical fatigue and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559442A (en) * | 2004-03-01 | 2005-01-05 | 张凤春 | Soft capsule of dried oviduct fat of forest frog |
| CN101371707A (en) * | 2007-08-22 | 2009-02-25 | 曾晓亮 | Pure forest frog thick fat soup health-care nutrient foodstuff and preparation method |
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2011
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559442A (en) * | 2004-03-01 | 2005-01-05 | 张凤春 | Soft capsule of dried oviduct fat of forest frog |
| CN101371707A (en) * | 2007-08-22 | 2009-02-25 | 曾晓亮 | Pure forest frog thick fat soup health-care nutrient foodstuff and preparation method |
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