CN106108016A - A kind of health food for relieving physical fatigue and preparation method thereof - Google Patents

A kind of health food for relieving physical fatigue and preparation method thereof Download PDF

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Publication number
CN106108016A
CN106108016A CN201610505197.3A CN201610505197A CN106108016A CN 106108016 A CN106108016 A CN 106108016A CN 201610505197 A CN201610505197 A CN 201610505197A CN 106108016 A CN106108016 A CN 106108016A
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health food
panacis quinquefolii
radix
physical fatigue
extract
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CN201610505197.3A
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王倩
李亚滁
申珂
汪涛
王祝彬
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GUANGZHOU SAIJIAN BIO-TECH Co Ltd
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GUANGZHOU SAIJIAN BIO-TECH Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/41Crassulaceae (Stonecrop family)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to field of health care food, be specifically related to a kind of health food for relieving physical fatigue, include Radix Rhodiolae extract 10 100 parts, Radix Panacis Quinquefolii 5 80 parts, arginine 5 70 parts by weight.Compared with prior art, the health food of the present invention has an advantage in that (1) few dosage is taken and can be rapidly achieved function of relieving physical fatigue;(2) raw material sources are natural, and not only alleviating physical fatigue is effective, and have green, safe and healthy feature, safe to the human body have no side effect;(3) can be made into sugar-free formulation product, applicable crowd is wider, and diabetics etc. also can long-term taking.The present invention also provides for the preparation method of above-mentioned health food, compared with prior art, have the advantage that for: (1) few dosage is taken this health food and can be played preferable effect;(2) water content control of health food prepared by this method is below 5%.

Description

A kind of health food for relieving physical fatigue and preparation method thereof
Technical field
The present invention relates to functional health-care food field, be specifically related to a kind of health food for relieving physical fatigue and system thereof Preparation Method.
Background technology
Doctor trained in Western medicine thinks that fatigue is that body uses the function transfinited and cause to reduce and the state that body is uncomfortable occurs.Fatigue can To be divided into physical fatigue and mental fatigue.Physical fatigue i.e. sports fatigue, refers to by the organism physiology machine caused by body movement Can be maintained on normal level and maybe can not maintain its original exercise intensity, and show showing of body movement ability decline As.When human body for a long time, carry out over loading physical exertion time, muscle group persistently or exceedingly shrinks, and consumes a large amount of While intramuscular energy substance, the metabolites such as lactic acid, carbon dioxide, water, serum urea nitrogen, the acidity in blood can be produced Also can increase.When these metabolites gather in muscle a certain amount of after, so that it may hinder muscle cell mobility, make flesh Meat can not proceed effective flexible, and stimulates human tissue cell and cerebral central nervous system, makes people produce extremity weary The senses of discomfort such as power, sleepy, muscular soreness, anorexia, such fatigue just creates.Owing to doctor trained in Western medicine thinks that fatigue is between healthy and disease A kind of state at sick edge, i.e. sub-health state, be not belonging to disease, be therefore not suitable for by Drug therapy, often with the element that supplements the nutrients, Rest carrys out fatigue alleviating.
The existing long history of understanding of Fatigue by Traditional Chinese Medicine, with organic conception from entirety understanding people and tired relation, recognizes Belong to the categories such as " empty ", " asthenia ", " deficient " for fatigue, in Huangdi's Internal Classics, fatigue is referred to as " tired ", " lassitude and weariness " more, " is stranded Thin ", " heavy sensation of the body " etc..Fatigue is often accompanied by the deficiency of vital energy symptom such as asthenia, lazy speech, and the traditional Chinese medical science thinks that natural endowment deficiency is plus being lost the day after tomorrow Degree is to produce tired main cause, and the kidney being the origin of congenital constitution, and the raw marrow of main bone, kidney qi weakness the most easily causes limb soft weak, tired Deng physical fatigue symptom.Loss will excessively generally comprise excessive fatigue, excessive thinking and anxiety and excess of sexual intercourse etc. the day after tomorrow.Motor process consumes energy Gas consumption, " Plain Questions lift pain opinion a piece " carries: labor antiperspirant of then panting goes, and inside and outside all gets over, therefore QI consumed.Move the most momental muscle power It is weak that activity can cause the body kidney yang deficiency of vital energy.Physical fatigue shows as spiritlessness and sparing of words, waist soreness, dizziness, spontaneous perspiration, cardiopalmus, deficient and weak pulse Deng, it is in the nature function and goes down or negative and positive of qi and blood loss, and the traditional Chinese medical science is with righting for this, uses tonification internal organs or benefiting vital QI and blood Method, this is basically identical with doctor trained in Western medicine result of study.
Patent publication No. is CN104305453A, publication date: 2015.01.28, and invention entitled a kind of Radix Panacis Quinquefolii meets anti- Tiring exercises health promoting beverage, is prepared by the raw materials in: Radix Panacis Quinquefolii 5-10, pueraria root powder 3-5, Radix Rhodiolae 5-10, Tremella 10-20, Fructus Jujubae 10-20, Fructus Hippophae 10-20, Radix Et Caulis Acanthopanacis Senticosi 10-20, Rhizoma Dioscoreae 10-20, Arillus Longan 10-20, Fructus Lycii 10-20, Semen Ormosiae Hosiei 10-20, Pericarpium Citri Reticulatae 5-10, Rhizoma Zingiberis 10-20, Radix Puerariae 10-20, Fructus Crataegi 20-30, Mel 30-40.Use the canned drink that this formula is made Material, for alleviating physical fatigue, not only taking dose is big, and onset is slow, further, owing to this formula with the addition of a large amount of saccharide Material, diabetics should not be drunk, and is suitable for crowd's narrow range.
Patent publication No. is CN104872751A, publication date: 2015.09.02, the function of invention entitled a kind of resisting fatigue Property beverage and preparation method thereof, is made up of following component: ginseng juice, Succus Rhizoma Dioscoreae, oligosaccharide, taurine, inositol, lysine, cigarette Amide, calcium pantothenate, caffeine, vitamin B6, vitamin B1, vitamin B12, sucrose, fructose, Sucus Mali pumilae, citric acid, citric acid Sodium, fruit essence, sodium carboxymethyl cellulose, tartaric acid, green tea extract, zinc gluconate, potassium chloride, vitamin C, water.Should The active component of formula contains caffeine, and the effect of caffeine is to stimulate nervus centralis, produces tingle, thus it is tired to alleviate muscle power Labor, but, long-term taking caffeine, health is produced ill effect.
In prior art, for health food for relieving physical fatigue exist side effect, sugar content is high, taking dose big, The problem that onset is slow, it is impossible to meet people and the pursuit of high quality healthy food is asked, therefore, need solution the problems referred to above badly.
Summary of the invention
Present invention aims to the deficiencies in the prior art, it is provided that one has no side effect, the most sugary, taking dose Less, rapid-action health food for relieving physical fatigue and preparation method thereof.
To achieve these goals, the present invention provides a kind of health food for relieving physical fatigue, by following weight proportion Raw material composition: Radix Rhodiolae extract 10-100 part, Radix Panacis Quinquefolii 5-80 part, arginine 5-70 part.
Radix Rhodiolae is Crassulaceae, the dry root and rhizome of Radix Rhodiolae.Its sweet in the mouth can be mended, can invigorating the spleen and benefiting QI, kind control Deficiency-weakness of spleen-QI, fatigue and weakness, again can tonifying the lung gas, support lung yin, control deficiency of both vital energy and Yin, cough with ropy sputum, alone i.e. have certain curative effect;" this Grass detailed outline grass portion " effect such as to indicate Radix Rhodiolae in volume 20 be " draft is top grade ", tool strengthening the body resistance, benefiting qi and nourishing blood.According to existing For medical science and Human Physiology theory, Radix Rhodiolae extract (mainly containing rhodioside) is to animal normal pressure hypoxia-bearing capability and motion Ability is all significantly increased, and can accelerate lactic acid metabolism, reduces myocardial oxygen consumption, improves cardiac reserve thus reaches resisting fatigue and make With.
Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii, and " Bencao Congxin " says that " tonifying the lung pathogenic fire reducing, born fluid go out tired for it Tired, empty and have the fire person suitable ", function boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, it is apt to control the card of deficiency of both QI and YIN.Modern pharmacological research confirms, west The main composition of Radix Panacis Quinquefolii is ginsenoside, has enhancing immunity, protects the liver, protects cranial nerve cell, antithrombotic, give protection against cancer and resist The effect of cancer, and the energy enhancing body adaptation ability to all nonspecific stimulations, can reduce feeling of fatigue.Correlational study is separately had to show Show, continuously mice is carried out gavage 30 days with Granulae Radix Panacis Quinquefolii, Radix Panacis Quinquefolii ball, three kinds of formulation products of Oral Liquid Radix Panacis Quinquefolii respectively After, the various dose of various preparations all can extend the mice burden swimming time, but resisting fatigue effect the most district between 3 kinds of dosage forms Not, wherein Radix Panacis Quinquefolii ball is pure Radix Panacis Quinquefolii powder, for extending mice swimming time, strengthens exercise tolerance effect best, therefore with pure It is best that Radix Panacis Quinquefolii powder makes product resisting fatigue effect.
Arginine is a kind of a-amino acid, is also one of 20 kinds of universal natural aminoacid.Arginine is known as body Interior transport and store amino acid whose important carrier, particularly important in intramuscular metabolism.Arginine synthesis capability in human body is relatively low, Part is needed to supplement from food.Arginine has a lot of source, and either Carnis Gallus domesticus, the flesh of fish and some vegetable all contain arginine, But the often content of the arginine in common food is relatively low, the nitric oxide negligible amounts of generation, do not possess related nutritional and be worth.Essence Propylhomoserin is nitric oxide production precursor, and supplementary arginine can significantly improve internal content of nitric oxide, and nitric oxide can be with dynamic Muscle cell in arteries and veins contacts and is allowed to loosen, and has expanded arteries so that blood pressure reduces, thus improves blood flow.
Further, described health food for relieving physical fatigue, it is made up of the raw material of following weight proportion: Radix Rhodiolae carries Take thing 10-100 part, Radix Panacis Quinquefolii 5-80 part, arginine 5-70 part, adjuvant 5-50 part.
Further, described health food for relieving physical fatigue, it is made up of the raw material of following weight proportion: Radix Rhodiolae carries Take thing 20-60 part, Radix Panacis Quinquefolii 10-40 part, arginine 5-20 part, adjuvant 5-30 part.
Further, during described adjuvant is microcrystalline Cellulose, maltodextrin, corn starch, pregelatinized Starch, mannitol At least one.
Addition as the microcrystalline Cellulose of adjuvant, it is simple to this health food is made capsule, not only taking convenience is few Dosage is taken and can be played preferable effect, and volume is little, easy to carry.
Addition as the maltodextrin of adjuvant, it is simple to this formula is prepared as granule.
Further, any one during described health food is capsule, tablet, granule, powder, pill.
Further, weight content >=2% of rhodioside in described Radix Rhodiolae extract.
Further, described Radix Panacis Quinquefolii is fines medicine, owing to the effective ingredient of Radix Panacis Quinquefolii is ginsenoside, and pulverizes relatively Carefully, so it can be by the good absorption of human body.
The present invention also provides for the preparation method of above-mentioned health food for relieving physical fatigue, comprises the following steps:
The pretreatment of Radix Panacis Quinquefolii: Radix Panacis Quinquefolii is dried the most successively, pulverizes, sieves, obtain Radix Panacis Quinquefolii powder, to Radix Panacis Quinquefolii Powder carries out sterilizing;
The pretreatment of Radix Rhodiolae extract: be placed in extraction pot by Radix Rhodiolae extract, adds ethanol, refluxes and extract, Obtain filtrate;Carry out twice being concentrated in vacuo by filtrate, it is thus achieved that concentrated solution;Concentrated solution is vacuum dried, obtains the dry leaching of Radix Rhodiolae Cream;Carry out Radix Rhodiolae dry extract pulverizing, sieving, obtain Radix Rhodiolae dry extract;
Mixing: the Radix Panacis Quinquefolii powder of described weight portion, Radix Rhodiolae dry extract, arginine are placed in mixer mixing and make Mixed powder, obtains described health food for relieving physical fatigue.
Further, further comprising the steps of: mixed powder and adjuvant are mixed corresponding capsule, tablet, granule, Powder or pill.
Further, the preparation of described capsule includes step: mixed powder and adjuvant are placed in capsule filling machine filling, fill out Temperature when filling controls at 18 DEG C-26 DEG C, and relative humidity during filling controls at below 45%-65%, obtains described capsule.
Temperature during filling controls at 18 DEG C-26 DEG C, and relative humidity during filling controls at below 45%-65%, be for Prevent the capsule moisture absorption in process of production.
Further, the preparation of described capsule further comprises the steps of: and is polished by capsule.
Further, in the pretreatment of Radix Panacis Quinquefolii:
Producing breeze to make concentrated solution be not easy, the weight content that Radix Panacis Quinquefolii is dried to Radix Panacis Quinquefolii moisture is less than 5%-9%;
In order to the granularity making Radix Panacis Quinquefolii is less, the Radix Panacis Quinquefolii after pulverizing crosses the screen cloth of 80-100 mesh;
In order to remove the bacterium colony in Radix Panacis Quinquefolii, use60Co carries out irradiation sterilization to Radix Panacis Quinquefolii powder, and irradiation dose is 3- 8kGy。
Further, in the pretreatment of Radix Rhodiolae extract:
In order to improve the dissolution rate of rhodiola active ingredient, adding concentration is the ethanol of 60%-80%, refluxes twice, the Once the 60%-80% ethanol of 6-10 times of weight of backflow addition Radix Rhodiolae extract, extracts 1-3 hour, obtains and extracts for the first time Liquid, second time backflow adds the 60%-80% ethanol of 4-8 times of weight of Radix Rhodiolae extract, extracts 0.5-1.5 hour, obtains the Secondary raffinate, extracting solution and second time extracting solution will filter after merging for the first time, obtain filtrate;
Filter to make concentrated solution be easier to and be dried, carrying out twice being concentrated in vacuo by filtrate, being concentrated into filtrate for the first time 20 DEG C of survey relative densities be 1.10-1.20g/ml, after delivering in vacuum concentration pot, second time is concentrated into 20 DEG C of surveys of filtrate Relative density is 1.20-1.30g/ml;
In order to make concentrated solution be dried rapidly, by concentrated solution vacuum be-0.1Mpa~-0.05Mpa, temperature is less than 70 It is vacuum dried under conditions of DEG C-90 DEG C;
Producing breeze to make concentrated solution be not easy, the weight content that concentrated solution is dried to concentrated solution moisture is less than 5%-9%.
The mechanism of action of the formula of a kind of health food for relieving physical fatigue of the present invention is as follows:
Inventive formulation is theoretical according to tcm health preserving and modern nutriology is theoretical, is extracted by the Radix Rhodiolae as Chinese herbal medicine Thing, Radix Panacis Quinquefolii with the arginine as nutrient according to special ratios with the use of, Synergistic.In terms of nutrient, science Reasonably use one of amino acid supplements arginine, be possible to prevent neurotransmitter disorderly to a certain extent, reduce fragrance Race's aminoacid decomposes in liver, reduces the concentration of aromatic amino acid in serum, makes the precursor of neurotransmitter in cerebral tissue subtract Few, thus fatigue alleviating;In terms of Chinese herbal medicine, Radix Rhodiolae and compound recipe energy hemopoietic thereof, increase in blood red carefully Born of the same parents and content of hemoglobin, improve human body hypoxia-bearing capability, strengthens liver and lactic acid dehydrogenase activity, promotes hepatic glycogen, inose Former decomposition and the glyconeogenesis of liver, and the effect of compound Rohoodiola exceedes single Radix Rhodiolae.Therefore, red in inventive formulation Herba hylotelephii erythrosticti extract, Radix Panacis Quinquefolii and arginic synergism so that this health promoting product is possessing preferable alleviating physical fatigue effect On the premise of, relative to existing health food, it is also equipped with safe without toxic side effect, the most sugary advantage, due to this health food The most sugary, therefore, its applicable crowd is wide, even if diabetes patient's also edible;Secondly, the Radix Rhodiolae in inventive formulation extracts The proportioning that thing, Radix Panacis Quinquefolii and arginine are scientific and reasonable so that even if this health food is in the case of taking dose is few, just possess Rapid-action advantage;Further, the adjuvant in inventive formulation interacts with Radix Rhodiolae extract, Radix Panacis Quinquefolii and arginine, shape Become stable homogeneous system.
The invention has the beneficial effects as follows:
A kind of health food for relieving physical fatigue of the present invention, is made up of the raw material of following weight proportion: Radix Rhodiolae carries Take thing 10-100 part, Radix Panacis Quinquefolii 5-80 part, arginine 5-70 part, adjuvant 5-50 part.Compared with prior art, described health food Have the advantage that
(1) tcm health preserving viewpoint being combined with modern nutriology theory, formula is with vigorate qi and replenish the blood, Yin-nourishing and body fluid promoting, adjustment For the purpose of internal organs negative and positive, turn to major function with resisting fatigue, antioxygen, through pharmacology test determine Radix Rhodiolae extract, Radix Panacis Quinquefolii, Arginine is primary raw material, and the synergism between three makes this health food have hypoxia-bearing capability and the fortune improving human body Dynamic endurance, thus delay fatigue, by the substantial amounts of test of inventor and research, preferably go out the optimum proportioning of each group, few dosage clothes With being rapidly achieved function of relieving physical fatigue;
(2) Radix Rhodiolae and Radix Panacis Quinquefolii by medicine-food two-purpose are main, then help with nutrient arginine, and raw material sources are natural, no Only alleviating physical fatigue is effective, and has green, safe and healthy feature, safe to the human body has no side effect;
(3) can be made into sugar-free formulation product, applicable crowd is wider, and diabetics etc. also can long-term taking.
The preparation method of a kind of health food for relieving physical fatigue of the present invention, compared with prior art, have is excellent Point is:
(1) combining Radix Rhodiolae extract, Radix Panacis Quinquefolii, arginic functional characteristics, few dosage takes this health food Play preferable effect;
(2) water content control of health food prepared by this method is below 5%, with " health food inspection and evaluation skill Art specification (2003 editions) " in 9% the comparing of regulation, be substantially reduced.
Technical characteristic and corresponding advantage thereof that the present invention adds will be set forth below in the following description, and these are by from following Description becomes obvious, or recognized by the practice of the present invention.
Detailed description of the invention
The invention will be further described with the following Examples.
Embodiment 1.
The health food for relieving physical fatigue of the present invention, is made up of the raw material of following weight proportion:
Radix Rhodiolae extract 60 parts
Radix Panacis Quinquefolii 30 parts
Arginine 10 parts.
Wherein, weight content >=2% of rhodioside in Radix Rhodiolae extract.
The preparation method of the health food for relieving physical fatigue of the present invention, comprises the following steps:
The pretreatment of Radix Panacis Quinquefolii: the Radix Panacis Quinquefolii of 30 weight portions is dried successively, pulverizes, is sieved, obtains Radix Panacis Quinquefolii powder, right Radix Panacis Quinquefolii powder carries out sterilizing;
The pretreatment of Radix Rhodiolae extract: be placed in extraction pot by the Radix Rhodiolae extract of 60 weight portions, adds ethanol, returns Flow and extract, obtaining filtrate;Carry out twice being concentrated in vacuo by filtrate, it is thus achieved that concentrated solution;Concentrated solution is vacuum dried, obtains red Herba hylotelephii erythrosticti dry extract;Carry out Radix Rhodiolae dry extract pulverizing, sieving, obtain Radix Rhodiolae dry extract;
Mixing: the Radix Panacis Quinquefolii powder of 30 weight portions, the Radix Rhodiolae dry extract of 60 weight portions, the arginine of 10 weight portions are put In mixer, mixed powder is made in mixing, obtains described health food for relieving physical fatigue.
Embodiment 2.
The health food for relieving physical fatigue of the present invention, is made up of the raw material of following weight proportion:
Wherein, weight content >=2% of rhodioside in Radix Rhodiolae extract.
The preparation method of the health food for relieving physical fatigue of the present invention, comprises the following steps:
The pretreatment of Radix Panacis Quinquefolii: the Radix Panacis Quinquefolii of 30 weight portions is dried successively, pulverizes, is sieved, obtains Radix Panacis Quinquefolii powder, right Radix Panacis Quinquefolii powder carries out sterilizing;
The pretreatment of Radix Rhodiolae extract: be placed in extraction pot by the Radix Rhodiolae extract of 60 weight portions, adds ethanol, returns Flow and extract, obtaining filtrate;Carry out twice being concentrated in vacuo by filtrate, it is thus achieved that concentrated solution;Concentrated solution is vacuum dried, obtains red Herba hylotelephii erythrosticti dry extract;Carry out Radix Rhodiolae dry extract pulverizing, sieving, obtain Radix Rhodiolae dry extract;
Mixing: the Radix Panacis Quinquefolii powder of 30 weight portions, the Radix Rhodiolae dry extract of 60 weight portions, the arginine of 10 weight portions are put In mixer, mixed powder is made in mixing;
The preparation of capsule: the microcrystalline Cellulose of mixed powder and 20 weight portions is placed in capsule filling machine filling, during filling Temperature controls at 22 DEG C, and relative humidity during filling controls below 60%, obtains the health care food of described alleviating physical fatigue Product, described health food is capsule.
Embodiment 3.
The health food for relieving physical fatigue of the present invention, is made up of the raw material of following weight proportion:
The preparation method of the health food for relieving physical fatigue of the present invention, comprises the following steps:
The pretreatment of Radix Panacis Quinquefolii: the weight content that the Radix Panacis Quinquefolii of 20 weight portions is dried to Radix Panacis Quinquefolii moisture is less than 7%, pulverize Radix Panacis Quinquefolii, and the Radix Panacis Quinquefolii after pulverizing crosses the screen cloth of 90 mesh, obtains Radix Panacis Quinquefolii powder, uses 60Co to enter Radix Panacis Quinquefolii powder Row irradiation sterilization, irradiation dose is 6kGy;
The pretreatment of Radix Rhodiolae extract:
Being placed in extraction pot by the Radix Rhodiolae extract of 10 weight portions, reflux twice, backflow for the first time adds Radix Rhodiolae and carries Taking 70% ethanol of 8 times of weight of thing, extract 2 hours, obtain extracting solution for the first time, second time backflow adds Radix Rhodiolae extract 70% ethanol of 6 times of weight, extracts 1 hour, obtains second time extracting solution, after extracting solution for the first time and second time extracting solution being merged Filter, obtain filtrate;
Carrying out twice being concentrated in vacuo by filtrate, the 20 DEG C of survey relative densities being concentrated into filtrate for the first time are 1.10g/ml, After delivering in vacuum concentration pot, it is 1.20g/ml that second time is concentrated into 20 DEG C of survey relative densities of filtrate, obtains concentrated solution;
By concentrated solution vacuum be-0.08Mpa, temperature is less than being vacuum dried, by concentrated solution under conditions of 80 DEG C It is dried to concentrated solution the weight content of moisture less than 5%, obtains Radix Rhodiolae dry extract, carry out Radix Rhodiolae dry extract pulverizing, mistake Sieve, obtains Radix Rhodiolae dry extract;
Mixing: the Radix Panacis Quinquefolii powder of 20 weight portions, the Radix Rhodiolae dry extract of 10 weight portions, the arginine of 5 weight portions are put Mix in mixer, obtain mixed powder;
The preparation of granule: the maltodextrin of described mixed powder and 10 weight portions is made granule, obtains described alleviation The health food of physical fatigue.
Embodiment 4.
The health food for relieving physical fatigue of the present invention, is made up of the raw material of following weight proportion:
The preparation method of the health food for relieving physical fatigue of the present invention, comprises the following steps:
The pretreatment of Radix Panacis Quinquefolii: the weight content that the Radix Panacis Quinquefolii of 10 weight portions is dried to Radix Panacis Quinquefolii moisture is less than 5%, pulverize Radix Panacis Quinquefolii, and the Radix Panacis Quinquefolii after pulverizing crosses the screen cloth of 80 mesh, obtains Radix Panacis Quinquefolii powder, uses 60Co to enter Radix Panacis Quinquefolii powder Row irradiation sterilization, irradiation dose is 3kGy;
The pretreatment of Radix Rhodiolae extract:
Being placed in extraction pot by the Radix Rhodiolae extract of 40 weight portions, reflux twice, backflow for the first time adds Radix Rhodiolae and carries Taking 60% ethanol of 6 times of weight of thing, extract 1 hour, obtain extracting solution for the first time, second time backflow adds Radix Rhodiolae extract 60% ethanol of 4 times of weight, extracts 0.5 hour, obtains second time extracting solution, will extracting solution and second time extracting solution merge for the first time Rear filtration, obtains filtrate;
Carrying out twice being concentrated in vacuo by filtrate, the 20 DEG C of survey relative densities being concentrated into filtrate for the first time are 1.10g/ml, After delivering in vacuum concentration pot, it is 1.20g/ml that second time is concentrated into 20 DEG C of survey relative densities of filtrate, obtains concentrated solution;
By concentrated solution vacuum be-0.1Mpa, temperature less than being vacuum dried under conditions of 70 DEG C, concentrated solution is done Dry to the weight content of moisture in concentrated solution less than 5%, obtain Radix Rhodiolae dry extract, carry out Radix Rhodiolae dry extract pulverizing, sieving, Obtain Radix Rhodiolae dry extract;
Mixing: the Radix Panacis Quinquefolii powder of 10 weight portions, the Radix Rhodiolae dry extract of 40 weight portions, the arginine of 20 weight portions are put Mix in mixer, obtain mixed powder;
The preparation of tablet and process: the corn starch of mixed powder and 5 weight portions is made tablet, obtain described alleviation muscle power Tired health food.
Embodiment 5.
The health food for relieving physical fatigue of the present invention, is made up of the raw material of following weight proportion:
The preparation method of the health food for relieving physical fatigue of the present invention, comprises the following steps:
The pretreatment of Radix Panacis Quinquefolii: the weight content that the Radix Panacis Quinquefolii of 40 weight portions is dried to Radix Panacis Quinquefolii moisture is less than 9%, pulverize Radix Panacis Quinquefolii, and the Radix Panacis Quinquefolii after pulverizing crosses the screen cloth of 100 mesh, obtains Radix Panacis Quinquefolii powder, uses 60Co to Radix Panacis Quinquefolii powder Carrying out irradiation sterilization, irradiation dose is 8kGy;
The pretreatment of Radix Rhodiolae extract:
Being placed in extraction pot by the Radix Rhodiolae extract of 100 weight portions, reflux twice, backflow for the first time adds Radix Rhodiolae and carries Taking 80% ethanol of 10 times of weight of thing, extract 3 hours, obtain extracting solution for the first time, second time backflow adds Radix Rhodiolae extract 80% ethanol of 8 times of weight, extract 1.5 hours, obtain second time extracting solution, will extracting solution and second time extracting solution close for the first time Filter after and, obtain filtrate;
Carrying out twice being concentrated in vacuo by filtrate, the 20 DEG C of survey relative densities being concentrated into filtrate for the first time are 1.20g/ml, After delivering in vacuum concentration pot, it is 1.30g/ml that second time is concentrated into 20 DEG C of survey relative densities of filtrate, obtains concentrated solution;
By concentrated solution vacuum be-0.05Mpa, temperature is less than being vacuum dried, by concentrated solution under conditions of 90 DEG C It is dried to concentrated solution the weight content of moisture less than 9%, obtains Radix Rhodiolae dry extract, carry out Radix Rhodiolae dry extract pulverizing, mistake Sieve, obtains Radix Rhodiolae dry extract;
Mixing: by the Radix Panacis Quinquefolii powder of 40 weight portions, the Radix Rhodiolae dry extract of 100 weight portions, the arginine of 70 weight portions It is placed in mixer mixing, obtains mixed powder;
The preparation of powder and process: the pregelatinized Starch of mixed powder and 30 weight portions is made powder, obtain described alleviation The health food of physical fatigue.
Embodiment 6.
The health food for relieving physical fatigue of the present invention, is made up of the raw material of following weight proportion:
The preparation method of the health food for relieving physical fatigue of the present invention, comprises the following steps:
The pretreatment of Radix Panacis Quinquefolii: the weight content that the Radix Panacis Quinquefolii of 80 weight portions is dried to Radix Panacis Quinquefolii moisture is less than 5%, pulverize Radix Panacis Quinquefolii, and the Radix Panacis Quinquefolii after pulverizing crosses the screen cloth of 100 mesh, obtains Radix Panacis Quinquefolii powder, uses 60Co to Radix Panacis Quinquefolii powder Carrying out irradiation sterilization, irradiation dose is 6kGy;
The pretreatment of Radix Rhodiolae extract:
Being placed in extraction pot by the Radix Rhodiolae extract of 80 weight portions, reflux twice, backflow for the first time adds Radix Rhodiolae and carries Taking 70% ethanol of 8 times of weight of thing, extract 2 hours, obtain extracting solution for the first time, second time backflow adds Radix Rhodiolae extract 70% ethanol of 6 times of weight, extracts 1 hour, obtains second time extracting solution, after extracting solution for the first time and second time extracting solution being merged Filter, obtain filtrate;
Carrying out twice being concentrated in vacuo by filtrate, the 20 DEG C of survey relative densities being concentrated into filtrate for the first time are 1.10g/ml, After delivering in vacuum concentration pot, it is 1.30g/ml that second time is concentrated into 20 DEG C of survey relative densities of filtrate, obtains concentrated solution;
By concentrated solution vacuum be-0.08Mpa, temperature is less than being vacuum dried, by concentrated solution under conditions of 80 DEG C It is dried to concentrated solution the weight content of moisture less than 5%, obtains Radix Rhodiolae dry extract, carry out Radix Rhodiolae dry extract pulverizing, mistake Sieve, obtains Radix Rhodiolae dry extract;
Mixing: the Radix Panacis Quinquefolii powder of 80 weight portions, the Radix Rhodiolae dry extract of 80 weight portions, the arginine of 40 weight portions are put Mix in mixer, obtain mixed powder;
The preparation of pill: the mannitol of mixed powder and 50 weight portions is made pill, obtains described alleviating physical fatigue Health food.
Test example 1.
The health food that embodiment 1 prepares is carried out edible safety and Ergonomy test, according to " health food inspection with Assessment technique specification (2003 editions) " content tests.Result is as follows:
One, Safety and toxicology test
(1) acute toxicity test
1, sample: sample prepared by formula and technique as described in embodiment 1.
2, laboratory animal: cleaning grade Kunming mouse.
3, acute oral toxicity test: use mtd test.The Kunming mouse selecting body weight to be 18g~22g 20, male and female half and half.Take sample contents 14.00g and add distilled water to 40ml (for allow to the Cmax of mouse stomach), one In a few days its mouse oral gavage 3 times are given in 4 hours in interval, and each gavage volume is 20ml/kg bw, and accumulated dose reaches 21.0g/kg Bw, first fasting 16 hours before gavage.Continuous Observation two weeks after gavage, record poisoning manifestations and death condition.
4, result: with the Kunming mouse of two kinds of sexes of dosage gavage of 21.0g/kg bw, observes 14 days, and result is shown in Table 1.Obvious poisoning symptom is had no, without dead in the observation period during experiment.Observation period terminate after to mouse liver, kidney, lungs, The main organs such as spleen are done gross anatomy and are observed, and show no obvious abnormalities change.Tested material is female to Kunming kind, the acute warp of male mice Mouth toxicity test maximum tolerated dose (MTD) is more than 21.0g/kg bw.According to " health food inspection and assessment technique specification (2003 editions) " in acute toxicity grading criteria, belong to nontoxic level.
Table 1: the acute toxicity testing result of sample mice
(2) 30 days feeding trials
1, sample: sample prepared by formula and technique as described in embodiment 1.
2, laboratory animal: SD rat 80, male and female half and half, male Mus body weight 70.6 ± 7.7g, female Mus body weight 70.8 ± 6.9g.
3, experimental technique: be divided into four groups, i.e. matched group and three tested material groups, often group 20, male and female half and half.
If the basic, normal, high dosage of sample is respectively 1.2g/kg bw, 1.8g/kg bw, 2.4g/kg bw, the most quite In human body recommended dose 50,75,100 times.Basic, normal, high dose of test liquid preparation time separately sampled product content 24.00g, 36.00g, 48.00g add distilled water to 200ml, press 1.0ml/100g bw volume gavage to rat, and matched group gavage gives Volume distilled water, once a day, continuous 30 days.
4, observation index and result:
4.1 ordinary circumstances are observed: observe the performance of animal, behavior, toxicity performance and death condition every day.Weigh weekly 1 time and food intake dose twice, calculate weekly food utilization and total food utilization.Result each treated animal growth promoter, Activity is all normal, without poisoning manifestations and death, each treated animal body weight weekly, weekly body weight evolution, weekly food-intake and weekly Food utilization, and TBW increments, total food-intake and the equal no difference of science of statistics of total foodstuff utilization rate (P > 0.05).
4.2 hematological examinations: measure each group of male and female rat hemoglobin content, packed cell volume, erythrocyte and leukocyte Counting, total number of blood platelet, leukocyte differential count (lymph, neutral grain, addicted to acid, monokaryon, basophilic).Test hematological every finger in latter stage Mark all in range of normal value, equal no difference of science of statistics (P > 0.05) compared with matched group.
4.3 Biochemical Indexes: measure glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, total protein, albumin, cholesterol, glycerol three Ester, blood urea nitrogen, creatinine, blood glucose.The experiment every biochemical indicator of experimental animal in latter stage is all in range of normal value, and each treated animal blood is raw Change index equal no difference of science of statistics (P > 0.05) compared with matched group.
Body weight and dirty body ratio measurement after 4.4 experiment end fasting: measure body weight after each group of male and female rat experiment end fasting, The dirty absolute weight of liver, the absolute weight of spleen, liver/body, spleen/body, kidney/body ratio, female Ren Mus, the absolute weight of male Mus testis Amount, testis/body weight ratio.Each internal organs absolute weight and dirty body between experiment experimental animal indices in latter stage and corresponding matched group Odds ratio relatively no difference of science of statistics (P > 0.05).
4.5 gross anatomies and tissue pathology checking: inspection matched group and each dosage group totally 80 rats altogether, female, male half and half. Cut open the color and luster of main organs, size, the morphosiss such as perusal after inspection, the heart, lung, liver,spleen,kidney, stomach, intestinal, testis (ovary) It is showed no obvious abnormalities.Carrying out histological examination under light microscopic, high dose group is female, the liver,spleen,kidney of Mus great and mighty or powerful, stomach, intestinal, testis (ovary), is showed no the Histopathologic changes relevant with experimental factor.
Above-mentioned acute oral toxicity test and 30 days feeding trial results show, this health food belongs to nontoxic level, permissible Long-term taking.
Two, Ergonomy test
1, sample: sample prepared by formula and technique as described in embodiment 1, for hard capsule, includes ecru powder, close Preserve at envelope, normal temperature drying.Human oral's recommended dose is 360mg/ grain × 2 tablet/time × 2 times/day, with everyone 60kg weighing machine Calculate, equivalent dosage 0.024g/kg/ days.Taking hard capsule content is sample.
2, laboratory animal: cleaning grade male mice in kunming 160, body weight 18~22g.
3, experimental technique: be divided into 4 big groups, 40 animals of every big group, every big group is divided into again matched group, basic, normal, high dosage Group, often 10 mices of group.Basic, normal, high dosage is respectively 0.12g/kg bw, 0.24g/kg bw, 0.72g/kg bw (respectively Be equivalent to the 5 of human body recommended amounts, 10,30 times), separately sampled product 1.20g, 2.40g, 7.20g add distilled water when being prepared by test solution To 200ml, by 0.2ml/10g bw volume to mouse stomach, matched group gavage gives isopyknic distilled water, once a day, Every alleviating physical fatigue index is measured after continuous 30 days.
4, observation index
4.1 impacts on Mouse Weight: after per os gives the sample 30d of mice various dose, each dosage group in four big groups And there was no significant difference (P > 0.05) between original body mass, body weight in mid-term, whole opisthosoma weight between matched group, show embodiment 1 sample The body weight growth of mice is had no significant effect by product.
4.2 impacts on the mice burden swimming time
Table 2: each walking weight load organizing mice
As seen from Table 2, walking weight load all ratio prolongations of matched group of sample each dosage group mice, and high dose group with Between matched group, difference has significance (P < 0.05), i.e. embodiment 1 sample 0.72g/kg bw dosage can significantly extend mice Walking weight load.
4.3 impacts on mice serum carbamide
Table 3: each serum urea measurement result organizing mice
As seen from Table 3, the serum urea content of sample each dosage group mice is below matched group, and high dose group with compare The difference of group has significance (P < 0.05), shows that embodiment 1 sample 0.72g/kg bw dosage can reduce tired mice serum urine Element produces.
4.4 impacts on after mouse movement three time point blood lactase acid values
Table 4: the blood lactase acid area under curve after each group mouse movement
As seen from Table 4,3 time point blood lactase acid area under curve of each dosage of sample are respectively less than matched group, and high dose Group has significance (P < 0.05) with the difference of matched group, shows that embodiment 1 sample 0.72g/kg bw dosage can reduce mice fortune Blood lactase acid area under curve after Dong.
4.5 impacts on Mouse Liver glycogen storage level
Table 5: each liver glycogen reserves amount organizing mice
As seen from Table 5, sample each dosage glycogen commercial weight is above matched group, and high dose group has aobvious with the difference of matched group Work property (P < 0.05), shows that embodiment 1 sample 0.72g/kg bw dosage can significantly improve Mouse Liver glycogen storage level.
4.6 functional evaluation results
Experimental result shows, per os gavage gives mice 0.12g/kg bw, 0.24g/kg bw, 0.72g/kg bw agent Embodiment 1 sample of amount 30 days, compared with matched group, can extend the walking weight load of mice, can reduce tired mice serum The generation of carbamide, reduces the blood lactase acid area under curve after mouse movement, can increase Mouse Liver glycogen storage level, the body to mice Heavily increase and have no significant effect, show that embodiment 1 sample has function of relieving physical fatigue.
It is last it should be noted that, above example is merely to illustrate technical scheme rather than protects the present invention The restriction of scope, although being explained in detail the present invention with reference to preferred embodiment, those of ordinary skill in the art should manage Solve, technical scheme can be modified or equivalent, without deviating from technical solution of the present invention essence and Scope.

Claims (10)

1. a health food for relieving physical fatigue, it is characterised in that be made up of the raw material of following weight proportion: Radix Rhodiolae carries Take thing 10-100 part, Radix Panacis Quinquefolii 5-80 part, arginine 5-70 part.
2. a kind of health food for relieving physical fatigue as claimed in claim 1, it is characterised in that by following weight proportion Raw material forms: Radix Rhodiolae extract 10-100 part, Radix Panacis Quinquefolii 5-80 part, arginine 5-70 part, adjuvant 5-50 part.
3. a kind of health food for relieving physical fatigue as claimed in claim 2, it is characterised in that by following weight proportion Raw material forms: Radix Rhodiolae extract 20-60 part, Radix Panacis Quinquefolii 10-40 part, arginine 5-20 part, adjuvant 5-30 part.
4. a kind of health food for relieving physical fatigue, it is characterised in that described adjuvant is micro- At least one in crystalline cellulose, maltodextrin, corn starch, pregelatinized Starch, mannitol.
5. a kind of health food for relieving physical fatigue, it is characterised in that described health food For any one in capsule, tablet, granule, powder, pill.
6. a kind of health food for relieving physical fatigue as according to any one of claim 1-3, it is characterised in that described red Weight content >=2% of rhodioside in Herba hylotelephii erythrosticti extract.
7. the preparation method of a health food for relieving physical fatigue as claimed in claim 1, it is characterised in that include with Lower step:
The pretreatment of Radix Panacis Quinquefolii: Radix Panacis Quinquefolii is dried successively, pulverizes, sieves, obtain Radix Panacis Quinquefolii powder, Radix Panacis Quinquefolii powder is gone out Bacterium;
The pretreatment of Radix Rhodiolae extract: be placed in extraction pot by Radix Rhodiolae extract, adds ethanol, refluxes and extract, obtaining Filtrate;Carry out twice being concentrated in vacuo by filtrate, it is thus achieved that concentrated solution;Concentrated solution is vacuum dried, obtains Radix Rhodiolae dry extract;Will Radix Rhodiolae dry extract carries out pulverizing, sieving, and obtains Radix Rhodiolae dry extract;
Mixing: the Radix Panacis Quinquefolii powder of described weight portion, Radix Rhodiolae dry extract, arginine are placed in mixer mixing and make mixing Powder, obtains described health food for relieving physical fatigue.
The preparation method of a kind of health food for relieving physical fatigue the most as claimed in claim 7, it is characterised in that also include Following steps:
Mixed powder and adjuvant are mixed and made into corresponding capsule, tablet, granule, powder or pill.
The preparation method of a kind of health food for relieving physical fatigue the most as claimed in claim 8, it is characterised in that described glue The preparation of capsule includes step:
Mixed powder and adjuvant are placed in capsule filling machine filling, and temperature during filling controls at 18 DEG C-26 DEG C, phase during filling To humid control at below 45%-65%, obtain described capsule.
10. the preparation method of health food for relieving physical fatigue as claimed in claim 7, it is characterised in that
In the pretreatment of Radix Panacis Quinquefolii:
Radix Panacis Quinquefolii is dried to Radix Panacis Quinquefolii the weight content of moisture less than 5%-9%;
Radix Panacis Quinquefolii after pulverizing crosses the screen cloth of 80-100 mesh;
Use60Co carries out irradiation sterilization to Radix Panacis Quinquefolii powder, and irradiation dose is 3-8kGy;
In the pretreatment of Radix Rhodiolae extract:
Adding concentration is the ethanol of 60%-80%, refluxes twice, and backflow for the first time adds 6-10 times of weight of Radix Rhodiolae extract 60%-80% ethanol, extracts 1-3 hour, obtains extracting solution for the first time, and second time backflow adds 4-8 times of weight of Radix Rhodiolae extract 60%-80% ethanol, extract 0.5-1.5 hour, obtain second time extracting solution, will extracting solution and second time extracting solution merge for the first time Rear filtration, obtains filtrate;
Carrying out twice being concentrated in vacuo by filtrate, the 20 DEG C of survey relative densities being concentrated into filtrate for the first time are 1.10-1.20g/ml, After delivering in vacuum concentration pot, it is 1.20-1.30g/ml that second time is concentrated into 20 DEG C of survey relative densities of filtrate;
By concentrated solution vacuum be-0.1 Mpa ~-0.05Mpa, temperature does less than carrying out vacuum under conditions of 70 DEG C-90 DEG C Dry;
Concentrated solution is dried to concentrated solution the weight content of moisture less than 5%-9%.
CN201610505197.3A 2016-06-28 2016-06-28 A kind of health food for relieving physical fatigue and preparation method thereof Pending CN106108016A (en)

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CN102552886A (en) * 2011-12-28 2012-07-11 江西宇骏生物工程有限公司 Oral superoxide dismutase (SOD) capsules having anti-oxidation effect and preparation method thereof
CN105211856A (en) * 2015-09-30 2016-01-06 北京康比特体育科技股份有限公司 A kind of fatigue resistant health food and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN1317340A (en) * 2001-02-28 2001-10-17 哈尔滨工大金工科技开发有限公司 Health food for diabetics
CN1853506A (en) * 2005-04-26 2006-11-01 连汝安 Health-care food for improving human immunity and production thereof
CN101595988A (en) * 2008-12-11 2009-12-09 广州中一药业有限公司 A kind of tired health food preparation and preparation method thereof of alleviating
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* Cited by examiner, † Cited by third party
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CN113397076A (en) * 2021-06-25 2021-09-17 长春帮尔保健食品有限公司 Traditional Chinese medicine beverage composition and preparation method thereof

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