CN104432099B - Health food containing vitamin K2 - Google Patents

Health food containing vitamin K2 Download PDF

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Publication number
CN104432099B
CN104432099B CN201410801527.4A CN201410801527A CN104432099B CN 104432099 B CN104432099 B CN 104432099B CN 201410801527 A CN201410801527 A CN 201410801527A CN 104432099 B CN104432099 B CN 104432099B
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calcium
vitamin
weight
percentage
health food
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CN104432099A (en
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王丽娜
张伟
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WEIHAI BAIHE BIOLOGY TECHNOLOGICAL Co Ltd
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WEIHAI BAIHE BIOLOGY TECHNOLOGICAL Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses health food containing vitamin K2. The health food is composed of the following components in percentage by weight: 0.02-0.1% of the vitamin K2, 0.01-0.1% of biotin, 10-32% of milk mineral salt, 2-10% of casein phosphopeptide, 1-8% of probiotics, 8-28% of whey protein powder, 9-22% of a pueraria extract and the balance being auxiliary materials. According to the food, natural components such as high-quality vitamin, protein, and probiotics are compounded to interact in an intestinal tract, so that the intestinal tract and the blood environment are perfected, the action of the vitamin K2 is promoted and the content of blood calcium is adjusted together with the vitamin K2. The health food is scientific and reasonable in composition, natural in ingredients, appropriate in proportion, reliable in efficacy and convenient to eat.

Description

One kind contains vitamin k2Health food
Technical field
The present invention relates to changing the dietetic product of food nutrition property, especially one kind contains vitamin k2Health care food Product.
Background technology
It is known that in human body, 99% calcium is stored in skeleton, in tooth and fingernail.1% calcium is present in blood and tissue In.Skeleton is equivalent to the calcium storehouse of human body, and the calcium deposited is more stable.Calcium in blood and tissue is calcium pond, Main Function: nerve Conduction and muscle contraction.Phosphorus is the constituent of ribosomal ribonucleic acid (dna), and phospholipid is composition necessary to all cell membrane, and phosphorus is also joined Catabolism with fat and fatty acid.In addition, every 2 grams of calcium need 1 gram of phosphorus in the forming process of bone, put down with reaching calcium phosphorus Weighing apparatus.It is not difficult that the mankind get enough phosphorus from food, has phosphorus in substantially any food, but takes purification when people is substantial amounts of When calcium, phosphorus can be extracted the two-to-one ecological relationship of synthesis by these calcium, and calcium phosphorus balance then can be broken, and assume phospholipid and lack Mistake state.And more than 40 kind of disease of human body is all relevant with calcium disorder.
At present, on market, the health food of " increase bone density " is broadly divided into two classes: a class is the health food of calcic, is Reach increase bone density purpose by direct supplement calcium, this kind of health food mainly passes through vitamin d3To promote the suction of calcium Receive, absorb and excessively easily cause the health problems such as calcium disorder, muscle bone pain, and calcium involve in too high, lead to calcium phosphorus ration Unbalance, thus leading to a series of sclerotin and intestinal absorption problem；Another kind of be free from calcium or not with replenish the calcium for purpose health care food Product, are to promote the absorption of calcium thus reaching increase bone density this purpose, such as soybean isoflavone, sulphuric acid by adjusting endocrine Chrondroitin.This kind of health food is mainly inherent regulation, but calcium Deficiency of Intake is equally problem, and has certain side effect, example As stimulated gastric mucosa, cause constipation etc..Therefore, invent a kind of regulating intestinal canal flora, alleviate calcium disorder and then improve osteoporosises Health food particularly important.
Content of the invention
In order to overcome deficiency of the prior art, a kind of composition of present invention offer is scientific and reasonable, composition is natural, proportioning is proper When, taking convenience is containing vitamin k2Health food.
The technical solution adopted for the present invention to solve the technical problems is: one kind contains vitamin k2Health food, it is special Levy and be: it comprises the following components in percentage by weight: vitamin k20.02～0.1%, biotin 0.01～0.1%, Ru Kuang Thing salt 10～32%, phosphopeptide caseinate 2～10%, probiotic bacteria 1～8%, lactalbumin powder 8～28%, Radix Puerariae extract 9～22%, Remaining is adjuvant, and the percentage by weight sum of each component is 100%.
Further, probiotic bacteria be by one of bacillus acidophilus, bacillus bifiduss, Lactobacillus plantarum or more than one.
Further, described adjuvant is made up of starch and Microcrystalline Cellulose, wherein, the percentage by weight of described starch For 6～25%, the percentage by weight of described Microcrystalline Cellulose is 6～25%.
The precedence technique scheme of the present invention is: the percentage by weight of described each component is: vitamin k20.06%th, biotin 0.04%th, newborn mineral salt 26%, phosphopeptide caseinate 3%, probiotic bacteria 6%, lactalbumin powder 21%, Radix Puerariae extract 16%, adjuvant 27.9%, wherein, in described adjuvant, the percentage by weight of starch is 12.5%, and the percentage by weight of Microcrystalline Cellulose is 15.4%.
The present invention containing vitamin k2Health food, can be made into health-caring capsule, by capsule body and being encapsulated in capsule body Content composition, through dispensing, mixing, filling, polishing, select and the operation such as pick and make capsule, producing content content is The health-caring capsule of the supplementary several mineral materials of 300mg～600mg/ grain.The concrete preparation technology of its capsule belongs to prior art, no Repeat again.
Usage of the present invention and consumption are: the daily recommended amounts of adult are 1.2g.Pressing human body recommended intake is that 2 times a day, often Secondary 2, can long-term taking.
The present invention is the natural components such as high-quality vitamin, protein, probiotic bacteria, and wherein, effect of each component is as follows: dimension life Plain k2Be to maintain the necessary nutrient of normal physiological function in human body, calcium played with the effect that management controls, control bone and Calcium metabolism, it is ensured that calcium effective mineralising deposition and holding on skeleton of absorption, eliminates osteoporosises, hyperosteogeny；Biotin Also known as w factor, the decomposition of fat and carbohydrate can be promoted, make them accelerate to change into the energy needed for physical activity, Help improve the regulation of blood glucose, biotin and vitamin k by improving the use of insulin and blood glucose2Collocation, function can be made Strengthening, effectively prevents calcium, the loss of phosphorus and burn fat；Puerarin in Radix Puerariae extract has certain to external bone formation Facilitation, can improve bone mineral content, bone mineral density and bone biomechanical intensity, and puerarin causes external and estrogen simultaneously Action character be consistent, also blood pressure lowering, improve cerebral circulation and myocardial function；Newborn mineral salt is a kind of new resource food, due to There is the calcium-phosphorus ratio close with human body it is considered to be outstanding raw material of replenishing the calcium；Phosphopeptide caseinate (cpp) ph in human body intestinal canal In neutral in weakly alkaline environment, calcium, ferrum, zinc ion can be chelated, protect it from by the phosphoric acid in meals, oxalic acid, phytic acid etc. Anion precipitates, and effectively facilitates the absorption to calcium, ferrum, zinc etc. and utilization；Lactalbumin purity is high, absorbance is high, Amino acid group Become the most reasonable, high-purity lactalbumin is in human body and vitamin k2In conjunction with can effectively strengthen bone strength, adjust blood calcium dense Degree is so as to reach normal level；Probiotic bacteria can help digest in vivo, absorb, the various nutrient of metabolism, such as: protein, sugar, Fiber, trace element etc., can be effectively improved intestinal environment, promote the antibacterial in people's intestinal to be directly synthesized vitamin k2, for human body Absorb.Also can synthesize nutrient, the application conversion of cholesterol and lipid metabolism simultaneously, purify gastroenteric environment, protection liver, The heart, kidney etc..The present invention has compounded the natural components such as high-quality vitamin, protein, probiotic bacteria, can interact in intestinal, Improve intestinal and blood environment, promote the absorption of vitamin and other nutrients.Wherein, cpp(phosphopeptide caseinate) addition Calcium, phosphorus, zinc ion being chelated, protecting it from being precipitated by aniones such as the phosphoric acid in meals, oxalic acid, phytic acid, thus effectively facilitating Absorption to calcium, phosphorus, zinc etc. and utilization, cpp, except promoting the absorption of calcium, can also promote the absorption of mineral, and Obviate the excessive injury to intestines and stomach of vitamin d；Biotin and vitamin k2Collocation, can make function intensified, both permissible Effectively prevent the loss of calcium, phosphorus, again can be with burn fat；High-purity lactalbumin is in human body and vitamin k2In conjunction with can have Effect strengthens bone strength, adjusts blood calcium concentration so as to reach normal level；Probiotic bacteria can assist synthetic vitamin in intestinal k2, promote vitamin k2Effect, work in coordination with its adjust blood calcium.The each component of the present invention is worked in coordination with it and is adjusted blood calcium, has and changes A series of health problems such as kind osteoporosises, regulating intestinal canal flora, alleviation calcium disorder.Compared with prior art, present invention composition Scientific and reasonable, composition is natural, proportioning is appropriate, taking convenience.
Specific embodiment
With reference to embodiments of the invention, the present invention is described further.
Raw materials used in the present embodiment be commercial products, wherein,
Vitamin k2Emerging purchased from Henan sky, its content is >=99%；This vitamin k2It is in human body, to maintain normal physiology work( The necessary nutrient of energy, plays the effect that management controls to calcium, controls bone and calcium metabolism it is ensured that the calcium taken in has on skeleton Effect mineralising deposition and holding, eliminate osteoporosises, hyperosteogeny；Vitamin k first2Prepare bigger space for calcium, catch More calcium, increase bone mass and bone density；Next allow calcium to crystallize more regular, increase bone strength；Vitamin k2Also remove blood Pipe calcium speckle, elimination hyperosteogeny, therefore play management and control effect to abnormal calcium metabolism.Vitamin k2Superpower calcium management function is right Respond well in treatment of vascular calcification, hyperosteogeny, thus reaching the purpose of protection cardiovascular and cerebrovascular vessel.
Biotin is purchased from upper seashore magnesium, and its content is >=99%；This biotin, also known as w factor, can promote fat and carbon water The decomposition of compound, makes them accelerate to change into the energy needed for physical activity, is helped by improving insulin and using of blood glucose Help the regulation improving blood glucose, biotin and vitamin k2Collocation, can make function intensified, effectively prevent calcium, the loss of phosphorus and combustion Burn fat；And biotin can promote the decomposition of fat and carbohydrate, them are made to accelerate to change into the energy needed for physical activity Amount.
Newborn mineral salt is derived from New Zealand's import, wherein content >=25% of calcium；Content >=13% of phosphorus；This newborn mineral salt is one Kind of new resource food, due to having the calcium-phosphorus ratio close with human body it is considered to be outstanding raw material of replenishing the calcium.Calcium and the pass of calitriol System, under normal circumstances, our human body can be automatically synthesized calitriol by sunlight, in order to decompose in our every daily ingestion foods Calcareous, and the calcium taking purification of our excess, the one wrong instruction of our automatic-balancing system will be given, internal, Blood, body fluid not calcium deficiency, then, the instruction producing calitriol is closed, and the calcium absorbing cannot get calitriol and can only run off, Just not saying it has also upset the normal operation of phosphorus.
Phosphopeptide caseinate can be given birth to purchased from Jiangxi, and its content is >=99%；This phosphopeptide caseinate (cpp) is in human body intestinal canal Interior ph in weakly alkaline environment, can chelate calcium, ferrum, zinc ion, protect it from by the phosphoric acid in meals, oxalic acid, plant in neutral The aniones such as acid precipitate, and effectively facilitate the absorption to calcium, ferrum, zinc etc. and utilization.
Probiotic bacteria is purchased from Shanghai promise Shen, wherein lactic acid bacteria sum/(cfu/g) >=5 × 107, bacillus bifiduss/(cfu/g) >= 2.5×107, bacillus acidophilus/(cfu/g) >=2.5 × 107, Lactobacillus plantarum/(cfu/g) >=2.5 × 107；Probiotic bacteria is in body Interior help digest, absorb, the various nutrient of metabolism, such as: protein, sugar, fiber, trace element etc., intestinal can be effectively improved Environment, promotes the antibacterial in people's intestinal to be directly synthesized vitamin k2, utilize for absorption of human body.Also nutrient, gallbladder can be synthesized simultaneously The application conversion of sterin and lipid metabolism, purify gastroenteric environment, protection liver, the heart, kidney etc..
Lactalbumin powder is derived from imported from America, and its protein content is >=90%；This lactalbumin be using advanced technologies from Milk separation and Extraction precious protein out, forms the many advantages quilt such as the most reasonable with its purity height, absorbance height, aminoacid Push away as " king of albumen ".High-purity lactalbumin is in human body and vitamin k2In conjunction with can effectively strengthen bone strength, adjust blood Calcium concentration is so as to reach normal level.
Radix Puerariae extract is purchased from Hanzhong sky Rangu, and its puerarin content is >=60%.Puerarin in Radix Puerariae extract is to body Outer bone formation has certain facilitation, can improve bone mineral content, bone mineral density and bone biomechanical intensity, Radix Puerariae simultaneously Element is caused and is consistent with the action character of estrogen in vitro, also blood pressure lowering, improve cerebral circulation and myocardial function.
The present invention has compounded the natural components such as high-quality vitamin, protein, probiotic bacteria, can interact, change in intestinal Kind intestinal and blood environment, promote the absorption of vitamin and other nutrients.Wherein, cpp(phosphopeptide caseinate) addition energy Chelating calcium, phosphorus, zinc ion, protect it from being precipitated by aniones such as the phosphoric acid in meals, oxalic acid, phytic acid, thus effectively facilitate right The absorption of calcium, phosphorus, zinc etc. and utilization.Cpp, except promoting the absorption of calcium, can also promote the absorption of mineral, and get rid of Except the excessive injury to intestines and stomach of vitamin d.Biotin and vitamin k2Collocation, can make function intensified, both can have Effect prevents the loss of calcium, phosphorus, again can be with burn fat, and high-purity lactalbumin is in human body and vitamin k2In conjunction with can be effective Strengthen bone strength, adjust blood calcium concentration so as to reach normal level.Probiotic bacteria can assist synthetic vitamin k in intestinal2, Promote vitamin k2Effect, work in coordination with its adjust blood calcium.The each component of the present invention is worked in coordination with it and is adjusted blood calcium, has improvement A series of health problems such as osteoporosises, regulating intestinal canal flora, alleviation calcium disorder.
Embodiment 1
One kind contains vitamin k2Health food, it comprises the following components in percentage by weight: vitamin k20.06%th, raw Thing element 0.04%, newborn mineral salt 26%, phosphopeptide caseinate 3%, probiotic bacteria 6%, lactalbumin powder 21%, Radix Puerariae extract 16%, auxiliary Material 27.9%, wherein, in adjuvant, the percentage by weight of starch is 12.5%, and the percentage by weight of Microcrystalline Cellulose is 15.4%.This reality Apply that example provided containing vitamin k2Health food composition scientific and reasonable, composition is natural, proportioning is appropriate, taking convenience.
Embodiment 2
One kind contains vitamin k2Health food, it comprises the following components in percentage by weight: vitamin k20.02%th, raw Thing element 0.1%, newborn mineral salt 32%, phosphopeptide caseinate 2%, bacillus acidophilus 3%, bacillus bifiduss 3%, Lactobacillus plantarum 2%, milk surum Egg albumen powder 8%, Radix Puerariae extract 18.88%, adjuvant 31%, wherein, starch 6%, Microcrystalline Cellulose 25% in adjuvant.The present embodiment institute There is provided containing vitamin k2Health food composition scientific and reasonable, composition is natural, proportioning is appropriate, taking convenience.
Embodiment 3
One kind contains vitamin k2Health food, it comprises the following components in percentage by weight: vitamin k20.1%th, raw Thing element 0.01%, newborn mineral salt 10%, phosphopeptide caseinate 7.89%, bacillus acidophilus 1%, lactalbumin powder 28%, Radix Puerariae extract 22%th, adjuvant 31%, wherein, starch 25%, Microcrystalline Cellulose 6% in adjuvant.The present embodiment provided containing vitamin k2Health care Food composition is scientific and reasonable, composition is natural, proportioning is appropriate, taking convenience.
Embodiment 4
One kind contains vitamin k2Health food, it comprises the following components in percentage by weight: vitamin k20.05%th, raw Thing element 0.05%, newborn mineral salt 25.9%, phosphopeptide caseinate 10%, bacillus acidophilus 2.5%, bacillus bifiduss 2.5%, lactalbumin Powder 25%, Radix Puerariae extract 9%, adjuvant 25%, wherein, starch 15%, Microcrystalline Cellulose 10% in adjuvant.The present embodiment is provided Containing vitamin k2Health food composition scientific and reasonable, composition is natural, proportioning is appropriate, taking convenience.
Finished product involved by the embodiment of the present invention 1～4, can be prepared into capsule by following process steps:
A () dispensing weighs according to percentage by weight: vitamin k 2, biotin, newborn mineral salt, phosphopeptide caseinate, prebiotic Bacterium, lactalbumin powder, Radix Puerariae extract, starch, Microcrystalline Cellulose, proceed in 300,000 grades of clean areas, and cross 80 mesh sieves respectively, standby With；
B vitamin k that step (a) is weighed by () mixing2, biotin, newborn mineral salt, phosphopeptide caseinate, probiotic bacteria, Lactalbumin powder, Radix Puerariae extract, starch, Microcrystalline Cellulose send into blender by the way of stirring while in mixing, stirring is mixed It is bonded to pink colour pool consistent, no color differnece, obtain mixed powder；
C the mixed powder that step (b) obtains is sent into Autocapsulefillingmachine and is packed in capsule shells by () filling, obtain guarantor Strong capsule；
D health-caring capsule that step (c) is obtained by () polishing is inserted and is processed by shot blasting in buffing machine so as to capsule shows Bright and clean；
E () choosing picks the choosing of the health-caring capsule after being polished step (d) and picks unless eurymeric ball, obtain eurymeric health-caring capsule；
(f) packaging, finished product: the eurymeric health-caring capsule obtained by step (e) is carried out bottling, encapsulates, finished product.
Below to contain vitamin k given by embodiment 12Health food carry out zoopery, further illustrate this Bright have the effects such as improve osteoporosises, regulating intestinal canal flora, alleviate calcium disorder.
1) material and method
1.1) sample: the capsule produced according to embodiment 1 is sample.
1.2) dosage group selection and tested material give mode: low calcium feed formula (gram): casein 10.0, analysis for soybean powder 15.0, wheat flour 54.0, Oleum Arachidis hypogaeae semen 4.0, cellulose 2.0, ain-76 salt-mixture 2.6, ain-76 mixed vitamin 1.0, chlorination Choline 0.2, dl- Methionine 0.2, starch 11.0, add caco3 to make feedstuff calcium content reach 150mg/100g, raise as low calcium Material.
According to human oral's recommended amounts, the sample of the present invention is that basic, normal, high dosage is respectively 0.25g/kg.bw, 0.50g/ Kg.bw, 1.50g/kg.bw(are respectively equivalent to 5 times, 10 times, 30 times that human body recommends consumption), when Calcium Carbonate reference substance is prepared, The Calcium Carbonate (being equivalent to the high dose of the present invention) of basic, normal, high dosage.When preparing sample, basic, normal, high dosage takes respectively 2.50g, 5.00g, 15.00g add deionized water to 100ml, and calcium carbonate control group takes 5.97g Calcium Carbonate to add deionized water extremely 100ml, low calcium matched group gives isopyknic deionized water, gives animal subject gavage respectively, daily gavage once, gavage body Amass as 11.0ml/100g.bw.
1.3) experimental situation condition: experimental situation is barrier environment.22 DEG C～24 DEG C of ambient temperature, humidity 52%～58%.
1.4) key instrument: sd-1000c bone mineral measuring instrument.
1.5) experimental technique:
Growth and development index: weigh in weekly and height.
Femur-bone densitometry: at the end of experiment, sacrificed by decapitation rat, peel off right femur, permanent through baking in 105 baking boxs Weight, after being cooled to room temperature, measures the length of femur and the bone density of midpoint and distal end.
Calcium content of bone measures: uses edta titration measuring after the gross weight weighing femur.
Functional component, physical and chemical index, sanitary index: according to enterprise-quality standard test.
2) experimental result
2.1) Data Processing in Experiment: carry out data conversion and statistical analysiss with spss11.0 software.
2.2) interpretation of result: give the calcium content of bone of tested material group or bone density be significantly higher than low calcium matched group, and with phase It is not significantly different from compared with dosage calcium carbonate control group, the absorbance of calcium is not less than calcium carbonate control group, can determine that tested material There is the effect increasing bone density；Its functional component index, physical and chemical index, Hygienic Index all meet company standard q/ The regulation of rch007-2009d.
The impact to rat body weight for table 1 sample
As shown in Table 1, experimental group rat initial with mid-term body weight compared with low calcium matched group no significant difference (p ＞ 0.05)；Calcium carbonate control group and high dose group rat latter stage body weight and weightening there were significant differences compared with low calcium matched group (p ＜ 0.01), the initial weight of high dose group experimental group rat.Mid-term weight, latter stage weight and its have a net increase of value added compared with calcium carbonate control group not There is marked difference (p ＞ 0.05).
The impact to rat height for table 2 sample
As shown in Table 2, initial and mid-term height no significant difference (p ＞ compared with low calcium matched group of each experimental group rat 0.05)；Calcium carbonate control group and high calcium dosage group rat latter stage height and its have compared with having a net increase of the value added matched group with low calcium notable Difference (p ＜ 0.01), high dose experimental group rat starves initial height, mid-term height, length and height have a net increase of value added Calcium Carbonate all the life Matched group is compared and is not significantly different from (p ＞ 0.05).
The impact to rat femur length and bone density for table 3 sample
As can be seen from Table 3, the femur length of high dose group rat, femur center bone density, femur distal end bone density Compared with corresponding calcium carbonate control group, it is not significantly different from (p ＞ 0.05)；Calcium carbonate control group, high calcium dosage group femur are long Degree is noticeably greater than low calcium matched group (p ＜ 0.01)；Calcium carbonate control group, middle dose group, high dose group rat femur center bone are close Degree is noticeably greater than low calcium matched group (p ＜ 0.01).Calcium carbonate control group and high dose group rat femur distal end bone density are notable More than low calcium matched group (p ＜ 0.01).
The femur weight of table 4 sample high dose group rat, the impact of femur calcium content
As can be seen from Table 4, the femur weight of sample high dose group rat, the impact of femur calcium content.High dose is tested The femur weight of group rat, femur calcium content and calcium total amount, compared with corresponding calcium carbonate control group, are not significantly different from (p ＞ 0.05)；Calcium carbonate control group, high calcium dosage group femur weight are noticeably greater than low calcium matched group (p ＜ 0.01)；Calcium Carbonate compares Group, middle dose group, high dose group rat femur TC and calcium content are noticeably greater than low calcium matched group (p ＜ 0.01).
Show through animal test results, having enhancing using the capsule of the technique preparation given by the present invention increases bone density Function.

Claims (3)

1. one kind contains vitamin k2Health food it is characterised in that: it comprises the following components in percentage by weight: vitamin k20.02～0.1%, biotin 0.01～0.1%, newborn mineral salt 10～32%, phosphopeptide caseinate 2～10%, probiotic bacteria 1～8%, Lactalbumin powder 8～28%, Radix Puerariae extract 9～22%, remaining is adjuvant；Described adjuvant is by starch and Microcrystalline Cellulose group Become, wherein, the percentage by weight of described starch is 6～25%, and the percentage by weight of described Microcrystalline Cellulose is 6～25%； The percentage by weight sum of each component is 100%.
2. one kind according to claim 1 contains vitamin k2Health food it is characterised in that: the weight of described each component Percentage ratio is: vitamin k20.06%th, biotin 0.04%, newborn mineral salt 26%, phosphopeptide caseinate 3%, probiotic bacteria 6%, milk surum egg White lead 21%, Radix Puerariae extract 16%, adjuvant 27.9%, wherein, in described adjuvant, the percentage by weight of starch is 12.5%, crystallite The percentage by weight of cellulose is 15.4%.
3. one kind according to claim 1 and 2 contains vitamin k2Health food it is characterised in that: described probiotic bacteria is By one of bacillus acidophilus, Bifidobacterium lactis, Lactobacillus plantarum or more than one.
CN201410801527.4A 2014-12-22 2014-12-22 Health food containing vitamin K2 Active CN104432099B (en)

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