CN107213271A - One kind alleviates asthenopia tablet and preparation method thereof - Google Patents

One kind alleviates asthenopia tablet and preparation method thereof Download PDF

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Publication number
CN107213271A
CN107213271A CN201710395968.2A CN201710395968A CN107213271A CN 107213271 A CN107213271 A CN 107213271A CN 201710395968 A CN201710395968 A CN 201710395968A CN 107213271 A CN107213271 A CN 107213271A
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Prior art keywords
tablet
asthenopia
seed extract
extract
lutein ester
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CN201710395968.2A
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Chinese (zh)
Inventor
林峰
潘迎春
马涛
蔡金文
刘悦
宋帅
张雨浩
王海轩
金振涛
田雨
王丽
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Jiangsu Grain Health Life Science & Technology Development Co Ltd
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Jiangsu Grain Health Life Science & Technology Development Co Ltd
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Priority to CN201710395968.2A priority Critical patent/CN107213271A/en
Publication of CN107213271A publication Critical patent/CN107213271A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02Algae
    • A61K36/05Chlorophycota or chlorophyta (green algae), e.g. Chlorella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Alleviate asthenopia tablet the invention discloses one kind.The alleviation asthenopia tablet includes by mass percentage:Cassia seed extract 5 30%, lycium ruthenicum 5 20%, lutein ester 1 12%, salt algae 1 10%, blackcurrant extract 5 20%, grape seed extract 5 20%, auxiliary material surplus.The alleviation asthenopia tablet that the present invention is provided can effectively protect eyesight, alleviate visual fatigue, prevent senile macular degeneration.Macular degeneration is improved by lutein ester, visual fatigue, livid ring around eye are alleviated by adding anthocyanin, promotes rhodopsin to synthesize by adding bata-carotene, many-side protection eyesight.The present invention also provides a kind of preparation method for alleviating asthenopia tablet.

Description

One kind alleviates asthenopia tablet and preparation method thereof
Technical field
Alleviate asthenopia tablet, more particularly to a kind of cassia seed extract, lycium ruthenicum powder, leaf Huang the present invention relates to one kind Plain ester, salt algae, alleviation asthenopia tablet of blackcurrant extract and grape seed extract and preparation method thereof.
Background technology
Retina is the vital tissue organ that human body produces vision, and light only has the normally functioning retina of arrival, ability Visual pattern is formed, excessively weak or too strong light can all influence the formation of normal vision image.If the intensity of light, illumination Time withstands forces more than retina, it will cause the damage of retina.Macular area is that retina Posterior pole is pigmentosa in the presence of one Region, is in yellow because of lutein containing high concentration, therefore is referred to as " macula lutea ".Macular area has unique tissue cellularity, bears Blame most sharp vision, colour vision and shape and feel function, retinal cones cell is distributed in this area intensive, and contains abundant leaf Flavine and luteole are macular pigment, and these pigments and macular function and anti-oxidative damage are closely related.
In the last few years, ascendant trend, especially acquired environment factor year by year was presented in China's myopia population and ophthalmology illness, than As excess eye-using, reading distance are too near, use computer cell phone for a long time.Low vision can cause eyes often dry and astringent and fatigue, Have a strong impact on study, the quality of live and work.Myopia through commonly using eye may occur in which that eyelid is heavy, there is foreign body sensation, and ophthalmodynia is bent Beche-de-mer without spike is poor, excessively not good with eye or general body state.Western medicine on the market can bring certain toxic side effect, the eye drip of fatigue-relieving Liquid is also to cure the symptoms, not the disease.It therefore one kind is provided can improve macular degeneration, alleviate visual fatigue, livid ring around eye, promotion and regard The alleviation asthenopia nutriment of rhodopsin synthesis seems and is extremely necessary.
The content of the invention
The present invention provides a kind of containing cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, blackcurrant extract, grape The alleviation asthenopia tablet of seed extract, for improving macular degeneration, alleviating visual fatigue, livid ring around eye, promotion visual purple Red matter synthesis.
The purpose of the present invention is achieved through the following technical solutions.
One kind alleviates asthenopia tablet, and its component includes cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, black Gallon extract, grape seed extract and auxiliary material.
In alleviation asthenopia tablet provided in an embodiment of the present invention, mass percent is as follows shared by each component:
It is provided in an embodiment of the present invention alleviation asthenopia tablet in, the auxiliary material include microcrystalline cellulose, xylitol, Isomaltoketose, Aspartame, inulin, sucrose, lactose, rice meal, resistant dextrin, cyclodextrine, silica, magnesium stearate One or more.
Further, it is further characterized in that, a kind of preparation method of improvement sleeping tablets as described above, including following step Suddenly;
S1, by recipe requirements measure each raw material, specifically include cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, Blackcurrant extract, grape seed extract and auxiliary material;
S2, each raw material obtained in step sl is well mixed;
S3, by the well mixed raw material prepared in step s 2 by tablet press machine carry out tabletting, so as to obtain shape Into solid tablet.
The present invention enters pine torch extract, lycium ruthenicum powder, lutein ester, salt algae, blackcurrant extract, grape seed extract Row coordinates prescription, can effectively play the effect of various composition, and is conducive to utilizing the synergy between each composition, effectively changes Kind macular degeneration, alleviation visual fatigue, livid ring around eye.This formula major technique effect is:
It can be promoted by the anthocyanidin and the synergy of beta carotene in grape seed extract and blackcurrant extract The palingenesis of rhodopsin, increases visual acuity, accelerates the adaptability to dark surrounds.Further, in matrimony vine Damaging action of the LBP-X energy antagonism AGEP to nerve cell.And by the cassia seed element in cassia seed, certainly Pine torch lactone, Chrysophanol, Physcion substantially increase the protective effect to retinal neuronal cell, suppress advanced glycosylation endproduct production The generation of thing and its component, the time of delay AGEP accumulation.LBP-X energy antagonism glycosylation in lycium ruthenicum powder End-product has protective effect to the damaging action of nerve cell to retinal neuronal cell.Lutein ester can be efficient simultaneously Free lutein is discharged, promotes the recovery of the retina of damage while retinal neuronal cell is protected.So, pass through each group Point effectively act synergistically, it is possible to reduce because light exposes the retinal damage caused, the people of raising is to photopic vision, scotopia and right The sensitivity level of short wavelength light, increases macula retinae density.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.These embodiments are interpreted as being merely to illustrate this hair It is bright rather than limit the scope of the invention.After the content of the invention recorded has been read, those skilled in the art can To be made various changes or modifications to the present invention, these equivalence changes and modification equally fall into the model that the claims in the present invention are limited Enclose.In the present invention, refered in particular to as non-, all amounts, part, percentage is weight, and all raw material can be purchased from market .
Contain cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, blackcurrant extract, Portugal the invention provides one kind The production method of the alleviation asthenopia tablet of grape seed extract, it will be appreciated, of course, that the tablet is solid tablet.It is described The production method for alleviating asthenopia tablet comprises the following steps;
S1, by recipe requirements measure each raw material, specifically include cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, Blackcurrant extract, grape seed extract and auxiliary material
S2, each raw material obtained in step sl is well mixed;
S3, the well mixed tablet press machine prepared in step s 2 is subjected to tabletting, so as to prepare to form solid piece Agent.
It is prepared into after fixed tablet and can be not limited solely to specific in embodiment directly according to certain amount bag distribution packaging Quantity, so as to form final product.In the present invention, the quality per tablet is 0.4~2g, the tablet quality of every bag of product For 5g.Certainly, the tablet quality of every bag of product can also be other quality, and the present invention is not limited this.
The invention will be further described by the following examples.
Embodiment 1
The alleviation asthenopia tablet provided in the present embodiment includes cassia seed extract, lycium ruthenicum powder, lutein ester, salt Algae, blackcurrant extract, grape seed extract, microcrystalline cellulose, resistant dextrin, lactose, sucrose, silica and stearic acid Magnesium, wherein above-mentioned raw materials are prepared as following.
Each component content is respectively in per 100g:
Then the raw material of above-mentioned quality proportioning is well mixed with batch mixer, direct tablet compressing, or 50 pieces/bottle packing.
Embodiment 2
The alleviation asthenopia tablet provided in the present embodiment includes cassia seed extract, lycium ruthenicum powder, lutein ester, salt Algae, blackcurrant extract, grape seed extract, microcrystalline cellulose, xylitol, lactose, silica and magnesium stearate, wherein on Raw material is stated to be prepared by following.
Each component content is respectively in per 100g:
Then the raw material of above-mentioned quality proportioning is well mixed with batch mixer, direct tablet compressing, or 60 pieces/bottle packing.
Embodiment 3
The improvement sleeping tablets provided in the present embodiment include cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, Blackcurrant extract, grape seed extract, microcrystalline cellulose, isomaltoketose, rice meal, cyclodextrine, lactose, titanium dioxide Silicon, wherein above-mentioned raw materials are prepared as following.
Table 3:Each component content is respectively in per 100g:
Then the raw material of above-mentioned quality proportioning is well mixed with batch mixer, direct tablet compressing, or 70 pieces/bottle packing.
Embodiment 4
The improvement sleeping tablets provided in the present embodiment include cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, Blackcurrant extract, grape seed extract, microcrystalline cellulose, Aspartame, inulin, rice meal, cyclodextrine, sucrose, dioxy SiClx, wherein above-mentioned raw materials are prepared as following.
Table 4:Each component content is respectively in per 100g:
Then the raw material of above-mentioned quality proportioning is well mixed with batch mixer, direct tablet compressing.
Embodiment 5
The improvement sleeping tablets provided in the present embodiment include cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, Blackcurrant extract, grape seed extract, microcrystalline cellulose, Aspartame, inulin, rice meal, cyclodextrine, sucrose, dioxy SiClx, wherein above-mentioned raw materials are prepared as following.
Table 5:Each component content is respectively in per 100g:
Embodiment 6
The improvement sleeping tablets provided in the present embodiment include cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, Blackcurrant extract, grape seed extract, microcrystalline cellulose, Aspartame, inulin, rice meal, cyclodextrine, sucrose, dioxy SiClx, wherein above-mentioned raw materials are prepared as following.
Table 6:Each component content is respectively in per 100g:
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art It may be appreciated other embodiment.

Claims (4)

1. one kind alleviates asthenopia tablet, it is characterised in that its component includes cassia seed extract, lycium ruthenicum powder, lutein Ester, salt algae, blackcurrant extract and grape seed extract.
2. alleviate asthenopia tablet as claimed in claim 1, it is characterised in that also including auxiliary material, the auxiliary material includes:It is micro- Crystalline cellulose, xylitol, isomaltoketose, Aspartame, inulin, Sucralose, lactose, sucrose, rice meal, resistant dextrin, Cyclodextrine, silica, the one or more of magnesium stearate.
3. alleviation asthenopia tablet according to claim 2, it is characterised in that:Mass percent shared by each component is such as Under:
4. a kind of preparation method according to claim 1 for alleviating asthenopia tablet, comprises the following steps:
S1, by recipe requirements measure each raw material, specifically include cassia seed extract, lycium ruthenicum powder, lutein ester, salt algae, it is black plus Logical sequence extract, grape seed extract, auxiliary material;
S2, each raw material obtained in step sl is well mixed;
S3, by the well mixed raw material prepared in step s 2 by tablet press machine carry out tabletting, so as to obtain solid piece Agent.
CN201710395968.2A 2017-05-31 2017-05-31 One kind alleviates asthenopia tablet and preparation method thereof Pending CN107213271A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108157568A (en) * 2017-12-29 2018-06-15 广东粤微食用菌技术有限公司 A kind of Combined candy for alleviating visual fatigue and its preparation method and application
CN108208835A (en) * 2018-02-02 2018-06-29 李万才 A kind of black, red matrimony vine compound eyeshield oral liquid and preparation method thereof
CN108524667A (en) * 2018-05-23 2018-09-14 南京中生生物科技有限公司 It is a kind of that there is the lutein ester composition and preparation method thereof for alleviating visual fatigue effect
CN109123311A (en) * 2018-10-19 2019-01-04 贵阳高新瑞得科技开发有限公司 A kind of effervescent tablet health food for alleviating visual fatigue
CN111214640A (en) * 2020-04-01 2020-06-02 梭医生物科技(上海)股份有限公司 Leaf yellow Chinese wolfberry tablet capable of rapidly improving eyesight and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101433638A (en) * 2007-11-16 2009-05-20 北京因科瑞斯医药科技有限公司 Composition with function for alleviating eyestrain and preparation method thereof
CN104161260A (en) * 2014-07-23 2014-11-26 北京中泰天和科技有限公司 Composition used for relieving asthenopia and preparation method thereof
CN105687483A (en) * 2016-03-09 2016-06-22 宁波君瑞生物科技有限公司 Granular preparation with function of improving eyesight

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101433638A (en) * 2007-11-16 2009-05-20 北京因科瑞斯医药科技有限公司 Composition with function for alleviating eyestrain and preparation method thereof
CN104161260A (en) * 2014-07-23 2014-11-26 北京中泰天和科技有限公司 Composition used for relieving asthenopia and preparation method thereof
CN105687483A (en) * 2016-03-09 2016-06-22 宁波君瑞生物科技有限公司 Granular preparation with function of improving eyesight

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108157568A (en) * 2017-12-29 2018-06-15 广东粤微食用菌技术有限公司 A kind of Combined candy for alleviating visual fatigue and its preparation method and application
CN108208835A (en) * 2018-02-02 2018-06-29 李万才 A kind of black, red matrimony vine compound eyeshield oral liquid and preparation method thereof
CN108524667A (en) * 2018-05-23 2018-09-14 南京中生生物科技有限公司 It is a kind of that there is the lutein ester composition and preparation method thereof for alleviating visual fatigue effect
CN109123311A (en) * 2018-10-19 2019-01-04 贵阳高新瑞得科技开发有限公司 A kind of effervescent tablet health food for alleviating visual fatigue
CN111214640A (en) * 2020-04-01 2020-06-02 梭医生物科技(上海)股份有限公司 Leaf yellow Chinese wolfberry tablet capable of rapidly improving eyesight and preparation method thereof

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