CN113952437A - Traditional Chinese medicine composition for preventing myopia and relieving eye fatigue and preparation method thereof - Google Patents

Traditional Chinese medicine composition for preventing myopia and relieving eye fatigue and preparation method thereof Download PDF

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CN113952437A
CN113952437A CN202111478076.1A CN202111478076A CN113952437A CN 113952437 A CN113952437 A CN 113952437A CN 202111478076 A CN202111478076 A CN 202111478076A CN 113952437 A CN113952437 A CN 113952437A
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parts
extraction
preventing myopia
fructus
traditional chinese
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王光辉
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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Abstract

The invention provides a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for preventing myopia and relieving asthenopia comprises the following raw materials in parts by weight: fructus Lycii, folium Mori, folium Eucommiae, semen Ziziphi Spinosae, fructus Corni, Poria, Bulbus Lilii, cortex Cinnamomi, radix Curcumae, flos Rosae Rugosae, flos Chrysanthemi, radix Angelicae sinensis, radix Glycyrrhizae, arillus longan, Folum Ilicis, Aronia melanocarpa fruit, radix Ginseng, fructus Alpinae Oxyphyllae and fructus Amomi rotundusThe cassia seed can effectively relieve eye fatigue and prevent myopia; the preparation method comprises the following steps: respectively drying, pulverizing and sieving raw materials, mixing, and placing into an extraction kettle for CO extraction2Performing supercritical extraction to obtain extractive solution, adding lutein, beta-carotene and collagen peptide into the extractive solution, and mixing; and then concentrating, drying and crushing to obtain a finished product.

Description

Traditional Chinese medicine composition for preventing myopia and relieving eye fatigue and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue and a preparation method thereof.
Background
Myopia is one of the refractive errors. When the eye is in a relaxed state of accommodation, parallel rays of light enter the eye, which focus in front of the retina, resulting in the inability to form a sharp image on the retina, known as a myopic eye. Traditional Chinese medicine considers that myopia is usually caused by poor eyesight, exhaustion due to working or insufficient endowment during learning and work and congenital heredity, the pathogenesis of the myopia is multi-heart-yang weakness, and the nerve light cannot be beyond the distance; or deficiency of both liver and kidney and insufficiency of essence and blood, which causes the deficiency of the spirit and the decline of the light and the inability to reach the spirit. In recent years, the incidence rate of myopia in China is on a remarkable rising trend, and myopia has become a great public health problem affecting the eye health of the national people, particularly teenagers. The most common ophthalmic diseases are listed as one of three diseases in the world, and the incidence rate of myopia in the population of China is about 33 percent and is 1.5 times of the average level of the world (accounting for 22 percent of the total population).
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which has the effects of nourishing liver and kidney, calming liver and improving eyesight, and can effectively relieve eye fatigue and prevent myopia.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, the method has simple process, and the prepared product has good use effect.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the invention provides a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which comprises the following raw materials in parts by weight: 10-20 parts of medlar, 10-15 parts of mulberry leaf, 10-20 parts of eucommia leaf, 5-12 parts of spina date seed, 5-12 parts of dogwood, 5-10 parts of poria cocos, 5-15 parts of lily, 5-15 parts of cinnamon, 5-12 parts of radix curcumae, 10-15 parts of rose, 8-15 parts of chrysanthemum, 5-12 parts of angelica sinensis, 5-12 parts of liquorice, 5-15 parts of longan, 1-5 parts of broadleaf holly leaf, 5-15 parts of aronia melanocarpa, 5-12 parts of ginseng, 8-10 parts of sharpleaf galangal fruit and 5-12 parts of cassia seed.
On the other hand, the embodiment of the invention provides a preparation method of a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which comprises the following steps: respectively mixing fructus Lycii, folium Mori, folium Eucommiae, semen Ziziphi Spinosae, fructus Corni, Poria, Bulbus Lilii, cortex Cinnamomi, radix Curcumae, flos Rosae Rugosae, flos Chrysanthemi, radix Angelicae sinensis, and radix GlycyrrhizaeDrying, pulverizing, sieving, mixing, and extracting with CO in an extraction kettle2Performing supercritical extraction to obtain extractive solution, adding lutein, beta-carotene and collagen peptide into the extractive solution, and mixing; then concentrating, drying and crushing to obtain the finished product.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
aiming at the first aspect, the embodiment of the invention provides a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which comprises the following raw materials in parts by weight: 10-20 parts of medlar, 10-15 parts of mulberry leaf, 10-20 parts of eucommia leaf, 5-12 parts of spina date seed, 5-12 parts of dogwood, 5-10 parts of poria cocos, 5-15 parts of lily, 5-15 parts of cinnamon, 5-12 parts of radix curcumae, 10-15 parts of rose, 8-15 parts of chrysanthemum, 5-12 parts of angelica sinensis, 5-12 parts of liquorice, 5-15 parts of longan, 1-5 parts of broadleaf holly leaf, 5-15 parts of aronia melanocarpa, 5-12 parts of ginseng, 8-10 parts of sharpleaf galangal fruit and 5-12 parts of cassia seed.
The traditional Chinese medicine composition for preventing myopia and relieving eye fatigue mainly takes medlar, mulberry leaves, chrysanthemum, broadleaf holly leaves, aronia melanocarpa fruits and other medicinal materials as main materials, has the effects of calming the liver and improving the eyesight, can effectively relieve eye fatigue and has the effect of preventing myopia. In the raw material formula, the medlar, the eucommia leaves, the dogwood, the angelica, the ginseng and the sharpleaf galangal fruit are combined and matched with each other, so that the effects of nourishing the liver and the kidney, enriching the blood, promoting the blood circulation and stimulating the menstrual flow are achieved; the mulberry leaves, the spina date seeds, the poria cocos, the lily, the cinnamon, the radix curcumae, the rose, the liquorice, the longan, the broadleaf holly leaves and the cassia seeds are matched with each other, so that the effects of dispelling wind, clearing heat, calming the liver, improving eyesight, clearing heart fire, calming the nerves, strengthening spleen and replenishing qi are achieved, and the long-distance excessive loss of spirit caused by heart-yang weakness is relieved and treated; and symptoms caused by deficiency of both liver and kidney and deficiency of essence and blood, such as low spirit and insufficient light. The raw material medicines are matched with each other, and have synergistic effect, so that the effects of nourishing liver and kidney, replenishing vital essence and nourishing blood, tonifying heart and benefiting qi, tranquilizing and calming the nerves and calming the liver and improving eyesight can be effectively achieved, the daily eye fatigue can be effectively relieved, the symptoms such as dry eye, blurred vision and the like can be relieved, the myopia can be prevented, the pseudomyopia can be improved and treated, the positive effects on treatment, prevention and control of the refractive myopia and the axial myopia can be achieved, and the increase of the myopia degree can be effectively controlled; most of the selected medicinal materials are medicinal and edible medicinal materials, so that the safety is better. The use effect is better, and the health care effect is better; in addition, the composition can be prepared into different dosage forms such as eye drops, eye patches, oral liquid and the like, and is convenient and quick to use.
Aiming at the second aspect, the embodiment of the invention provides a preparation method of a traditional Chinese medicine composition for preventing myopia and relieving asthenopia, which comprises the following steps: respectively drying fructus Lycii, folium Mori, folium Eucommiae, semen Ziziphi Spinosae, fructus Corni, Poria, Bulbus Lilii, cortex Cinnamomi, radix Curcumae, flos Rosae Rugosae, flos Chrysanthemi, radix Angelicae sinensis, radix Glycyrrhizae, arillus longan, Folum Ilicis, fructus Sorbi Pohuashanensis, radix Ginseng, fructus Alpinae Oxyphyllae and semen Cassiae, pulverizing, sieving, mixing, and placing into an extraction kettle for CO extraction2Performing supercritical extraction to obtain extractive solution, adding lutein, beta-carotene and collagen peptide into the extractive solution, and mixing; then concentrating, drying and crushing to obtain the finished product.
The preparation method of the traditional Chinese medicine composition for preventing myopia and relieving asthenopia comprises the steps of drying, crushing and screening medlar, mulberry leaves, eucommia leaves, spina date seeds, dogwood, poria cocos, lily, cinnamon parts, radix curcumae, roses, chrysanthemum, angelica sinensis, liquorice, longan, broadleaf holly leaves, aronia melanocarpa fruits, ginseng, fructus alpiniae oxyphyllae and semen cassiae, and removing excessive moisture in the raw materials through drying to avoid adverse effects of the moisture on the subsequent steps; each crushed raw material medicine can be mixed more evenly, and effective components in the raw material medicines can be fully extracted through extraction in subsequent steps, so that the using effect of the product is further improved. Crushing and mixing, putting the raw materials into an extraction kettle for CO2Supercritical extraction by CO2The effective component with in the crude drug that supercritical fluid extraction can be more abundant draws out, and its extraction efficiency is higher, can reduce effective component's waste and loss, helps further promoting the effect of product, more is favorable to the plant use. Adding lutein and beta-bupleuri radix into the extractive solutionThe finished product is prepared by uniformly mixing the carotene and the collagen peptide, concentrating, drying and crushing, and can be directly brewed and drunk by adding water in use, thereby being convenient and quick. The whole preparation method is simple in flow, the prepared product can effectively achieve the effects of relieving eye fatigue and preventing myopia, and the use is convenient and quick.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The embodiment of the invention provides a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which comprises the following raw materials in parts by weight: 10-20 parts of medlar, 10-15 parts of mulberry leaf, 10-20 parts of eucommia leaf, 5-12 parts of spina date seed, 5-12 parts of dogwood, 5-10 parts of poria cocos, 5-15 parts of lily, 5-15 parts of cinnamon, 5-12 parts of radix curcumae, 10-15 parts of rose, 8-15 parts of chrysanthemum, 5-12 parts of angelica sinensis, 5-12 parts of liquorice, 5-15 parts of longan, 1-5 parts of broadleaf holly leaf, 5-15 parts of aronia melanocarpa, 5-12 parts of ginseng, 8-10 parts of sharpleaf galangal fruit and 5-12 parts of cassia seed.
In the above examples, the efficacy of each raw material was as follows:
medlar: nourishing liver and kidney, replenishing vital essence and improving eyesight; can be used for treating asthenia, soreness of waist and knees, vertigo, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion, and blurred vision;
mulberry leaf: disperse wind-heat, clear lung-heat and moisten dryness, clear liver and improve vision; can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight;
eucommia leaves: nourishing liver and kidney, strengthening tendons and bones, and lowering blood pressure; mainly treating lumbago, backache, soreness and weakness of feet and knees and hypertension;
wild jujube seed: tonify liver, calm heart, arrest sweating, promote salivation; can be used for treating vexation, insomnia, palpitation, dreaminess, asthenia, hyperhidrosis, body fluid deficiency, and thirst;
dogwood fruit: tonifying liver and kidney, arresting seminal emission and relieving depletion; can be used for treating vertigo, tinnitus, soreness of waist and knees, sexual impotence, spermatorrhea, enuresis, frequent micturition, metrorrhagia, leukorrhagia, and sweating. Internal heat wasting thirst;
tuckahoe, poria cocos: promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; can be used for treating edema, oliguria, palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia;
lily: nourishing yin and moistening lung, clearing heart fire and tranquilizing; can be used for treating chronic cough due to yin deficiency, blood-stained sputum, vexation, palpitation, insomnia, dreaminess, absentmindedness;
cinnamon: replenishing fire and supporting yang, guiding fire to the source, dispelling cold and relieving pain, and promoting blood circulation and stimulating the menstrual flow; can be used for treating sexual impotence, cold womb, psychroalgia of waist and knee, asthma due to kidney deficiency, vertigo due to yang deficiency, conjunctival congestion, pharyngalgia, psychroalgia of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, dolphin, amenorrhea, and dysmenorrhea;
turmeric root-tuber: promoting qi circulation, removing blood stasis, clearing away heart-fire, relieving depression, promoting bile flow, and eliminating jaundice; can be used for treating amenorrhea, dysmenorrhea, chest and abdomen distention pain, pricking pain, fever unconsciousness, epilepsy, jaundice, and dark urine;
and (3) rose: promoting qi circulation, resolving stagnation, regulating blood, and relieving pain; can be used for treating liver and stomach qi pain, anorexia, emesis, menoxenia, traumatic injury and pain;
chrysanthemum: dispelling wind and clearing heat, calming liver and improving eyesight; can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, and blurred vision;
chinese angelica: enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation; can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, menoxenia, amenorrhea, dysmenorrhea, asthenia cold abdominal pain, constipation due to intestinal dryness, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease;
licorice root: invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the above medicines; can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, and sore, and relieving drug toxicity and pungency;
longan: invigorating heart and spleen, replenishing qi and blood, invigorating spleen and stomach, and nourishing muscle; anxiety impairs the spleen, dizziness, insomnia, palpitation, asthenia, weakness after illness or after delivery, and blood loss due to spleen deficiency;
and (3) kudingcha: dispelling wind, clearing heat, improving eyesight and promoting fluid production; headache due to wind-heat, toothache, conjunctival congestion, purulent otitis media, aphtha, fever polydipsia, diarrhea, dysentery;
aronia melanocarpa fruit: the product is rich in nutrition, and can be used for treating hypertension, heart disease, cardiovascular disease, cerebrovascular disease, protecting liver and vision, and preventing myopia;
ginseng: to reinforce primordial qi, relieve collapse and promote fluid production, tranquilize mind; treating consumptive disease, anorexia, listlessness, regurgitation, diarrhea, cough, dyspnea, spontaneous perspiration, palpitation, amnesia, vertigo, headache, sexual impotence, frequent micturition, diabetes, metrorrhagia, infantile pavor, and deficiency of both qi and blood;
fructus alpiniae oxyphyllae: warming spleen, warming kidney, consolidating qi, and arresting seminal emission; for cold-air abdominal pain, vomiting and diarrhea, excessive saliva, nocturnal emission, dribbling urine, and nocturia;
cassia seed: clearing heat, improving eyesight, moistening intestines and relaxing bowels; can be used for treating conjunctival congestion, photophobia, lacrimation, headache, vertigo, dim eyesight, and constipation.
The traditional Chinese medicine composition for preventing myopia and relieving eye fatigue mainly takes medlar, mulberry leaves, chrysanthemum, broadleaf holly leaves, aronia melanocarpa fruits and other medicinal materials as main materials, has the effects of calming the liver and improving the eyesight, can effectively relieve eye fatigue and has the effect of preventing myopia. In the raw material formula, the medlar, the eucommia leaves, the dogwood, the angelica, the ginseng and the sharpleaf galangal fruit are combined and matched with each other, so that the effects of nourishing the liver and the kidney, enriching the blood, promoting the blood circulation and stimulating the menstrual flow are achieved; the mulberry leaves, the spina date seeds, the poria cocos, the lily, the cinnamon, the radix curcumae, the rose, the liquorice, the longan, the broadleaf holly leaves and the cassia seeds are matched with each other, so that the effects of dispelling wind, clearing heat, calming the liver, improving eyesight, clearing heart fire, calming the nerves, strengthening spleen and replenishing qi are achieved, and the long-distance excessive loss of spirit caused by heart-yang weakness is relieved and treated; and symptoms caused by deficiency of both liver and kidney and deficiency of essence and blood, such as low spirit and insufficient light. The raw material medicines are matched with each other, and have synergistic effect, so that the effects of nourishing liver and kidney, replenishing vital essence and nourishing blood, tonifying heart and benefiting qi, tranquilizing and calming the nerves and calming the liver and improving eyesight can be effectively achieved, the daily eye fatigue can be effectively relieved, the symptoms such as dry eye, blurred vision and the like can be relieved, the myopia can be prevented, the pseudomyopia can be improved and treated, the positive effects on treatment, prevention and control of the refractive myopia and the axial myopia can be achieved, and the increase of the myopia degree can be effectively controlled; the using effect is better, and the health care effect is better; in addition, the composition can be prepared into different dosage forms such as eye drops, eye patches, oral liquid and the like, and is convenient and quick to use.
Further, in some embodiments of the present invention, the raw materials are used in the following amounts by weight: 15 parts of medlar, 12 parts of mulberry leaves, 10 parts of eucommia leaves, 10 parts of spina date seeds, 9 parts of dogwood, 9 parts of poria cocos, 9 parts of lily, 9 parts of cinnamon, 8 parts of radix curcumae, 12 parts of rose, 10 parts of chrysanthemum, 8 parts of angelica sinensis, 8 parts of liquorice, 8 parts of longan, 2 parts of broadleaf holly leaves, 8 parts of aronia melanocarpa fruits, 8 parts of ginseng, 8 parts of fructus alpiniae oxyphyllae and 8 parts of semen cassiae.
In the embodiment, the dosage and the proportion of the raw material medicines are further limited, so that the raw material medicines can be better combined and matched with each other to realize synergistic interaction, the beneficial effects of the raw material medicines can be fully exerted, and the product can effectively play the effects of nourishing liver and kidney, benefiting essence, nourishing blood, tonifying heart, benefiting qi, tranquilizing mind, calming liver and improving eyesight and is more beneficial to use.
Further, in some embodiments of the present invention, the raw materials further include 0.008 parts by weight of lutein, 0.3 parts by weight of beta-carotene, and 10 parts by weight of collagen peptide.
In the above embodiment, lutein is the main pigment existing in macular area of human eye retina, and can help retina of eye to resist ultraviolet ray, and for eye, lutein is an important antioxidant playing a role, and by supplementing lutein, it is helpful to maintain visual endurance, improve visual reaction time, and reduce visual injury. Beta-carotene is an antioxidant that, when ingested into the human digestive organs, is converted to vitamin a, which maintains eye and skin health, improves nyctalopia, rough skin conditions, and helps protect the body from free radical damage. By supplementing collagen peptide, the transmittance of the vitreous body and the cornea in the eyeball can be improved, so that the vitreous body and the cornea are kept transparent, and the collagen peptide plays a vital role in improving the health and the light sensitivity of retina and optic nerve. By adding the three components, the nutritional value of the product can be further enhanced, and nutrition is supplemented for human bodies, so that the effects of relieving eye fatigue, improving pseudomyopia and mild myopia and preventing myopia are further enhanced, and the use is facilitated.
The embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which comprises the following steps: respectively drying fructus Lycii, folium Mori, folium Eucommiae, semen Ziziphi Spinosae, fructus Corni, Poria, Bulbus Lilii, cortex Cinnamomi, radix Curcumae, flos Rosae Rugosae, flos Chrysanthemi, radix Angelicae sinensis, radix Glycyrrhizae, arillus longan, Folum Ilicis, fructus Sorbi Pohuashanensis, radix Ginseng, fructus Alpinae Oxyphyllae and semen Cassiae, pulverizing, sieving, mixing, and placing into an extraction kettle for CO extraction2Performing supercritical extraction to obtain extractive solution, adding lutein, beta-carotene and collagen peptide into the extractive solution, and mixing; then concentrating, drying and crushing to obtain the finished product.
In the above embodiment, firstly, the medlar, the mulberry leaves, the eucommia leaves, the spina date seeds, the dogwood, the poria cocos, the lily, the cinnamon, the radix curcumae, the rose, the chrysanthemum, the angelica sinensis, the liquorice, the longan, the broadleaf holly leaves, the aronia melanocarpa fruit, the ginseng, the alpinia oxyphylla kernel and the cassia seeds are dried, crushed and sieved, and excessive moisture in the raw materials is removed through drying, so that adverse effects of the moisture on the subsequent steps are avoided; each crushed raw material medicine can be mixed more evenly, and effective components in the raw material medicines can be fully extracted through extraction in subsequent steps, so that the using effect of the product is further improved. Crushing and mixing, putting the raw materials into an extraction kettle for CO2Supercritical extraction by CO2The effective component with in the crude drug that supercritical fluid extraction can be more abundant draws out, and its extraction efficiency is higher, can reduce effective component's waste and loss, helps further promoting the effect of product, more is favorable to the plant use. Then adding the lutein, the beta-carotene and the collagen peptide into the extract, uniformly mixing, concentrating, drying and crushing to obtain a finished product, and when the finished product is used, the finished product can be directly brewed and drunk by adding water, so that the preparation is convenient and quick. The whole preparation method has simple process, and the prepared product canThe eye fatigue can be effectively relieved, the myopia can be prevented, and the use is convenient and fast.
Further, in some embodiments of the present invention, the lycium barbarum, the mulberry leaves, the eucommia ulmoides leaves, the spina date seeds, the dogwood, the poria cocos, the lily, the cinnamon parts, the curcuma aromatica, the rose, the chrysanthemum, the angelica sinensis, the liquorice, the longan, the broadleaf holly leaves, the aronia melanocarpa fruit, the ginseng, the alpinia oxyphylla kernel and the cassia seeds are dried until the water content is 6-9 wt%, and then are crushed and sieved by a 30-60-mesh sieve.
In the embodiment, by drying the raw materials until the water content is 6-9 wt%, smooth proceeding of subsequent steps can be better ensured, adverse effects of redundant water on the subsequent preparation process can be avoided, and the quality of the product can be further improved; the particle size of the crushed powder particles is controlled by crushing and sieving the powder particles by a 30-60-mesh sieve, so that the effective ingredients in the raw materials can be extracted by extraction in the subsequent steps, and the using effect of the product is further enhanced.
Further, in some embodiments of the invention, the CO2During supercritical extraction, the extraction temperature is 35-45 ℃ and the extraction pressure is 25-40 MPa.
In the above examples, by reacting with CO2The extraction temperature and extraction pressure of supercritical extraction are controlled, and CO can be controlled by controlling the temperature2The density of the supercritical fluid further improves the dissolving capacity of the supercritical fluid, improves the extraction efficiency, enables effective ingredients in the raw materials to be fully extracted, and is favorable for further enhancing the using effect of the product.
Further, in some embodiments of the invention, the CO2In supercritical extraction, CO2The flow rate is 16-25kg/h, and the extraction time is 1-3 h.
In the above examples, by reacting with CO2The flow and the extraction time are controlled, so that the raw materials and CO can be better controlled2The contact time of the device ensures the extraction efficiency, is also beneficial to controlling the production cost and is more beneficial to production and use.
Further, in some embodiments of the invention, the CO2During supercritical extraction, 3 wt% of ethanolAnd the water ethanol is used as an entrainer.
In the above embodiment, 3 wt% of anhydrous ethanol is added as an entrainer during extraction, so that the extraction efficiency can be further improved, some active ingredients which are difficult to extract in the raw materials can be extracted more easily through extraction, the waste and loss of the active ingredients are reduced, and the use effect of the product is further improved.
Further, in some embodiments of the invention, concentration to a relative density of 1.15 to 1.22 is followed by spray drying.
In the embodiment, the concentration is carried out until the relative density is 1.15-1.22, and the spray drying is carried out, so that on one hand, the concentration of the effective components in the product can be further improved through the concentration, the using effect of the product is enhanced, and meanwhile, the subsequent spray drying is more favorably carried out, and the production is more favorably carried out.
Further, in some embodiments of the present invention, the air inlet temperature during spray drying is 140-.
In the embodiment, the air inlet temperature of spray drying is controlled, so that the product can be dried better, and the phenomena of wall adhesion and the like are avoided; through smashing and sieving with 100 mesh sieve, can control the particle size of product granule to convenient partial shipment also can be more convenient use, be favorable to further promoting the quality of product.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The embodiment provides a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which is prepared by the following method: respectively drying 12g of medlar, 10g of mulberry leaf, 14g of eucommia leaf, 6g of spina date seed, 8g of dogwood, 5g of tuckahoe, 5g of lily, 5g of cinnamon, 10g of radix curcumae, 10g of rose, 8g of chrysanthemum, 6g of angelica, 8g of liquorice, 5g of longan, 3g of broadleaf holly leaf, 10g of aronia melanocarpa fruit, 6g of ginseng, 8g of sharpleaf galangal fruit and 6g of cassia seed until the water content is 9 wt%, crushing, sieving with a 60-mesh sieve, uniformly mixing, putting into an extraction kettle, adding 3 wt% of absolute ethyl alcohol as an entrainer,carrying out CO2Supercritical extraction at 35 deg.C under 30MPa with CO2The flow rate is 16kg/h, and the extraction time is 3 h; obtaining extract liquor, adding 0.008g of lutein, 0.3g of beta-carotene and 10g of collagen peptide into the extract liquor, and uniformly mixing; then concentrating to relative density of 1.15, then spray drying at the temperature of 160 ℃, then crushing and sieving with a 100-mesh sieve to obtain the finished product.
Example 2
The embodiment provides a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which is prepared by the following method: respectively drying 18g of medlar, 14g of mulberry leaf, 10g of eucommia leaf, 8g of spina date seed, 12g of dogwood, 10g of tuckahoe, 12g of lily, 14g of cinnamon, 8g of radix curcumae, 15g of rose, 12g of chrysanthemum, 10g of angelica, 10g of liquorice, 12g of longan, 3g of broadleaf holly leaf, 10g of aronia melanocarpa fruit, 8g of ginseng, 8g of sharpleaf galangal fruit and 12g of cassia seed until the water content is 8 wt%, crushing the dried materials, sieving the crushed materials with a 40-mesh sieve, uniformly mixing the materials, putting the mixture into an extraction kettle, adding 3 wt% of absolute ethyl alcohol as an entrainer, and carrying out CO separation2Supercritical extraction at 45 deg.C under 25-40MPa with CO2The flow rate is 20kg/h, and the extraction time is 2 h; obtaining extract liquor, adding 0.008g of lutein, 0.3g of beta-carotene and 10g of collagen peptide into the extract liquor, and uniformly mixing; then concentrating to relative density of 1.20, then spray drying at the temperature of 150 ℃, then crushing and sieving with a 100-mesh sieve to obtain the finished product.
Example 3
The embodiment provides a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which is prepared by the following method: respectively drying 15g of medlar, 13g of mulberry leaf, 15g of eucommia leaf, 8g of spina date seed, 8g of dogwood, 10g of tuckahoe, 12g of lily, 10g of cinnamon, 6g of radix curcumae, 14g of rose, 13g of chrysanthemum, 10g of angelica, 12g of liquorice, 12g of longan, 5g of broadleaf holly leaf, 15g of aronia melanocarpa, 12g of ginseng, 10g of sharpleaf galangal fruit and 12g of cassia seed until the water content is 8 wt%, crushing the dried materials, sieving the crushed materials with a 30-mesh sieve, uniformly mixing the materials, putting the mixture into an extraction kettle, adding 3 wt% of absolute ethyl alcohol as an entrainer, and carrying out CO separation2Supercritical extraction at the extraction temperatureThe temperature is 45 ℃, the extraction pressure is 40MPa, and CO is2The flow rate is 25kg/h, and the extraction time is 3 h; obtaining extract liquor, adding 0.008g of lutein, 0.3g of beta-carotene and 10g of collagen peptide into the extract liquor, and uniformly mixing; then concentrating to relative density of 1.22, then spray drying at the temperature of 160 ℃, then crushing and sieving with a 100-mesh sieve to obtain the finished product.
Example 4
The embodiment provides a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which is prepared by the following method: respectively drying 10g of medlar, 10g of mulberry leaf, 10g of eucommia leaf, 6g of spina date seed, 8g of dogwood, 6g of tuckahoe, 5g of lily, 5g of cinnamon, 8g of radix curcumae, 10g of rose, 8g of chrysanthemum, 6g of angelica, 5g of liquorice, 8g of longan, 1g of broadleaf holly leaf, 5g of aronia melanocarpa fruit, 8g of ginseng, 8g of sharpleaf galangal fruit and 6g of cassia seed until the water content is 6 wt%, crushing, sieving with a 60-mesh sieve, uniformly mixing, putting into an extraction kettle, adding 3 wt% of absolute ethyl alcohol as an entrainer, and carrying out CO separation2Supercritical extraction at 45 deg.C under 35MPa with CO2The flow rate is 22kg/h, and the extraction time is 2 h; obtaining extract liquor, adding 0.008g of lutein, 0.3g of beta-carotene and 10g of collagen peptide into the extract liquor, and uniformly mixing; then concentrating to relative density of 1.20, then spray drying at the temperature of 160 ℃, then crushing and sieving with a 100-mesh sieve to obtain the finished product.
Example 5
The embodiment provides a traditional Chinese medicine composition for preventing myopia and relieving eye fatigue, which is prepared by the following method: respectively drying 15g of medlar, 12g of mulberry leaf, 10g of eucommia leaf, 10g of spina date seed, 9g of dogwood, 9g of tuckahoe, 9g of lily, 9g of cinnamon, 8g of radix curcumae, 12g of rose, 10g of chrysanthemum, 8g of angelica, 8g of liquorice, 8g of longan, 2g of broadleaf holly leaf, 8g of aronia melanocarpa fruit, 8g of ginseng, 8g of sharpleaf galangal fruit and 8g of cassia seed until the water content is 8 wt%, crushing, sieving with a 60-mesh sieve, uniformly mixing, putting into an extraction kettle, adding 3 wt% of absolute ethyl alcohol as an entrainer, and carrying out CO separation2Supercritical extraction at 45 deg.C under 40MPa with CO2The flow rate is 20kg/h, during extractionThe time is 3 h; obtaining extract liquor, adding 0.008g of lutein, 0.3g of beta-carotene and 10g of collagen peptide into the extract liquor, and uniformly mixing; then concentrating to relative density of 1.22, then spray drying at the temperature of 160 ℃, then crushing and sieving with a 100-mesh sieve to obtain the finished product.
Test examples
80 cases of patients diagnosed with pseudomyopia or mild myopia (less than or equal to-3.00D) are collected, wherein 42 cases of pseudomyopia patients and 38 cases of mild myopia patients are treated by using the traditional Chinese medicine composition for preventing myopia and relieving asthenopia provided by the embodiment 5 of the invention once a day for 90 days, and the patients are required not to excessively use eyes during the treatment period to keep eyes clean; changes in patient symptoms before and after treatment were recorded. The results are shown in Table 1.
Inclusion criteria were: the glasses meet the corresponding diagnosis standard, and can be used normally for correction treatment; treatment was voluntarily given under informed conditions.
Exclusion criteria: (iii) suffer from other ocular diseases; there was a clear family genetic history.
The criteria for therapeutic effect are as follows:
and (3) curing: the vision is recovered to be normal, and the myopia diopter of the image test optometry disappears after the mydriasis to form an emmetropia;
the method has the following advantages: the vision is obviously recovered compared with the vision before treatment;
invalid; symptoms were unchanged compared to before treatment.
TABLE 1
Disease species Number of cases Cure of disease Is effective Invalidation
Pseudomyopia 42 39 3 0
Mild myopia 38 29 9 0
Table 2 shows the vision changes before and after treatment for patients with mild myopia.
TABLE 2
Disease species Number of people Before treatment After treatment
Mild myopia 38 0.622±0.183 1.034±0.141
According to the results, the traditional Chinese medicine composition for preventing myopia and relieving asthenopia provided by the embodiment of the invention can effectively relieve and treat pseudomyopia and mild myopia, and has an obvious using effect.
The following are some typical cases:
liu Jie, male, 12 years old, was examined to have pseudomyopia; after the traditional Chinese medicine composition for preventing myopia and relieving asthenopia provided by the invention is continuously used for three months, the eyesight is checked to recover to be normal, no relapse occurs within one year, and the effect is obvious.
Zhao, a woman in 9 years old, with blurred vision, and by checking that the vision is 0.6, the eyes are sour and astringent; after the traditional Chinese medicine composition for preventing myopia and relieving asthenopia provided by the invention is continuously used for three months, the eye acerbity symptom disappears, the vision is recovered to 1.0, no recurrence occurs within one year, and the effect is obvious.
Wu Chi, male, age 16, with both eyes vision 0.5; after the traditional Chinese medicine composition for preventing myopia and relieving asthenopia provided by the invention is continuously used for three months, the vision of both eyes is recovered to 1.0, no relapse occurs within one year, and the effect is obvious.
In summary, the traditional Chinese medicine composition for preventing myopia and relieving asthenopia and the preparation method thereof provided by the embodiments of the present invention mainly use the medlar, the mulberry leaf, the chrysanthemum, the broadleaf holly leaf, the aronia melanocarpa fruit and other medicinal materials, so as to play a role in suppressing hyperactive liver and improving eyesight, effectively relieve asthenopia and play a role in preventing myopia. In the raw material formula, the medlar, the eucommia leaves, the dogwood, the angelica, the ginseng and the sharpleaf galangal fruit are combined and matched with each other, so that the effects of nourishing the liver and the kidney, enriching the blood, promoting the blood circulation and stimulating the menstrual flow are achieved; the mulberry leaves, the spina date seeds, the poria cocos, the lily, the cinnamon, the radix curcumae, the rose, the liquorice, the longan, the broadleaf holly leaves and the cassia seeds are matched with each other, so that the effects of dispelling wind, clearing heat, calming the liver, improving eyesight, clearing heart fire, calming the nerves, strengthening spleen and replenishing qi are achieved, and the long-distance excessive loss of spirit caused by heart-yang weakness is relieved and treated; and symptoms caused by deficiency of both liver and kidney and deficiency of essence and blood, such as low spirit and insufficient light. The raw material medicines are matched with each other, and have synergistic effect, so that the effects of nourishing liver and kidney, replenishing vital essence and nourishing blood, tonifying heart and benefiting qi, tranquilizing and calming the nerves and calming the liver and improving eyesight can be effectively achieved, the daily eye fatigue can be effectively relieved, the symptoms such as dry eye, blurred vision and the like can be relieved, the myopia can be prevented, the pseudomyopia can be improved and treated, the positive effects on treatment, prevention and control of the refractive myopia and the axial myopia can be achieved, and the increase of the myopia degree can be effectively controlled; the using effect is better, and the health care effect is better; in addition, the composition can be prepared into different dosage forms such as eye drops, eye patches, oral liquid and the like, and is convenient and quick to use.
The preparation method comprises the steps of firstly, drying, crushing and sieving medlar, mulberry leaves, eucommia leaves, spina date seeds, dogwood, poria cocos, lily, cinnamon, radix curcumae, roses, chrysanthemum, angelica sinensis, liquorice, longan, broadleaf holly leaves, aronia melanocarpa fruit, ginseng, fructus alpiniae oxyphyllae and semen cassiae, removing excessive moisture in raw materials through drying, and avoiding adverse effects of the moisture on subsequent steps; each crushed raw material medicine can be mixed more evenly, and effective components in the raw material medicines can be fully extracted through extraction in subsequent steps, so that the using effect of the product is further improved. Crushing and mixing, putting the raw materials into an extraction kettle for CO2Supercritical extraction by CO2The effective component with in the crude drug that supercritical fluid extraction can be more abundant draws out, and its extraction efficiency is higher, can reduce effective component's waste and loss, helps further promoting the effect of product, more is favorable to the plant use. Then adding the lutein, the beta-carotene and the collagen peptide into the extract, uniformly mixing, concentrating, drying and crushing to obtain a finished product, and when the finished product is used, the finished product can be directly brewed and drunk by adding water, so that the preparation is convenient and quick. The whole preparation method is simple in flow, the prepared product can effectively achieve the effects of relieving eye fatigue and preventing myopia, and the use is convenient and quick.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. The traditional Chinese medicine composition for preventing myopia and relieving asthenopia is characterized by comprising the following raw materials in parts by weight: 10-20 parts of medlar, 10-15 parts of mulberry leaf, 10-20 parts of eucommia leaf, 5-12 parts of spina date seed, 5-12 parts of dogwood, 5-10 parts of poria cocos, 5-15 parts of lily, 5-15 parts of cinnamon, 5-12 parts of radix curcumae, 10-15 parts of rose, 8-15 parts of chrysanthemum, 5-12 parts of angelica sinensis, 5-12 parts of liquorice, 5-15 parts of longan, 1-5 parts of broadleaf holly leaf, 5-15 parts of aronia melanocarpa, 5-12 parts of ginseng, 8-10 parts of sharpleaf galangal fruit and 5-12 parts of cassia seed.
2. The traditional Chinese medicine composition for preventing myopia and relieving asthenopia according to claim 1, which is prepared from the following raw materials in parts by weight: 15 parts of medlar, 12 parts of mulberry leaves, 10 parts of eucommia leaves, 10 parts of spina date seeds, 9 parts of dogwood, 9 parts of poria cocos, 9 parts of lily, 9 parts of cinnamon, 8 parts of radix curcumae, 12 parts of rose, 10 parts of chrysanthemum, 8 parts of angelica sinensis, 8 parts of liquorice, 8 parts of longan, 2 parts of broadleaf holly leaves, 8 parts of aronia melanocarpa fruits, 8 parts of ginseng, 8 parts of fructus alpiniae oxyphyllae and 8 parts of semen cassiae.
3. The traditional Chinese medicine composition for preventing myopia and relieving asthenopia as claimed in claim 1, wherein the raw materials further comprise 0.008 parts by weight of lutein, 0.3 parts by weight of beta-carotene and 10 parts by weight of collagen peptide.
4. A method for preparing a Chinese medicinal composition for preventing myopia and relieving asthenopia according to any one of claims 1 to 3, which comprises the following steps: respectively drying fructus Lycii, folium Mori, folium Eucommiae, semen Ziziphi Spinosae, fructus Corni, Poria, Bulbus Lilii, cortex Cinnamomi, radix Curcumae, flos Rosae Rugosae, flos Chrysanthemi, radix Angelicae sinensis, radix Glycyrrhizae, arillus longan, Folum Ilicis, fructus Sorbi Pohuashanensis, radix Ginseng, fructus Alpinae Oxyphyllae and semen Cassiae, pulverizing, sieving, mixing, and placing into an extraction kettle for CO extraction2Performing supercritical extraction to obtain extractive solution, adding lutein, beta-carotene and collagen peptide into the extractive solution, and mixing;then concentrating, drying and crushing to obtain the finished product.
5. The method of claim 4, wherein the fructus Lycii, folium Mori, folium Eucommiae, semen Ziziphi Spinosae, fructus Corni, Poria, Bulbus Lilii, cortex Cinnamomi, radix Curcumae, flos Rosae Rugosae, flos Chrysanthemi, radix Angelicae sinensis, radix Glycyrrhizae, arillus longan, Folum Ilicis, Aronia melanocarpa fruit, radix Ginseng, fructus Alpinae Oxyphyllae, and semen Cassiae are dried to a water content of 6-9 wt%, pulverized, and sieved with 30-60 mesh sieve.
6. The method for preparing a Chinese medicinal composition for preventing myopia and relieving asthenopia as claimed in claim 4, wherein the composition comprises CO2During supercritical extraction, the extraction temperature is 35-45 ℃ and the extraction pressure is 25-40 MPa.
7. The method for preparing a Chinese medicinal composition for preventing myopia and relieving asthenopia as claimed in claim 4, wherein the composition comprises CO2In supercritical extraction, CO2The flow rate is 16-25kg/h, and the extraction time is 1-3 h.
8. The method for preparing a Chinese medicinal composition for preventing myopia and relieving asthenopia as claimed in claim 4, wherein the composition comprises CO2During supercritical extraction, 3 wt% of absolute ethyl alcohol is added as an entrainer.
9. The method for preparing a Chinese medicinal composition for preventing myopia and relieving asthenopia according to claim 4, which comprises concentrating to relative density of 1.15-1.22, and spray drying.
10. The method for preparing a Chinese medicinal composition for preventing myopia and alleviating asthenopia as claimed in claim 9, wherein the air inlet temperature is 140-160 deg.C during spray drying, and the composition is pulverized and sieved with 100 mesh sieve after drying.
CN202111478076.1A 2021-12-06 2021-12-06 Traditional Chinese medicine composition for preventing myopia and relieving eye fatigue and preparation method thereof Pending CN113952437A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107837343A (en) * 2017-10-31 2018-03-27 张西洁 A kind of preparation method for alleviating kopiopia, the compound traditional Chinese medicine composite for the treatment of myopia and its pill
CN111012840A (en) * 2019-12-26 2020-04-17 刘永 Ginseng and chrysanthemum health tea for relieving eye fatigue and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107837343A (en) * 2017-10-31 2018-03-27 张西洁 A kind of preparation method for alleviating kopiopia, the compound traditional Chinese medicine composite for the treatment of myopia and its pill
CN111012840A (en) * 2019-12-26 2020-04-17 刘永 Ginseng and chrysanthemum health tea for relieving eye fatigue and preparation method thereof

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