CN105125727A - Traditional Chinese medicine composition for treating allergic conjunctivitis and preparing method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating allergic conjunctivitis and a preparing method thereof and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from purslane, radix sophorae flavescentis, rhizoma coptidis, radix rehmanniae, common monkshood mother roots, fructus forsythiae, cortex dictamni, semen leonuri, chrysanthemums, tribulus terrestris, caulis akebiae, semen cassiae and liquorice. The traditional Chinese medicine composition has the treatment advantages of being good in treatment effect, treating both symptoms and root causes, and combining regulation and treatment, relapse is not prone to occurring, and the composition has the technical advantages of being simple in preparation technology, stable in medicine efficacy, high in universality, easy to apply and popularize and the like.

Description

A kind of Chinese medicine composition for the treatment of anaphylaxis conjunctivitis and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of anaphylaxis conjunctivitis and preparation method thereof.

Background technology

Allergic ophthalmopathy is one of modal eye surface diseases, and wherein anaphylaxis conjunctivitis is modal type.According to statistics, about have the people of more than 5% to go to a doctor because of allergic ophthalmopathy in the world, and wherein the ratio of anaphylaxis conjunctivitis is more than 50%, in recent years, due to factors such as eye cosmetic use, contact lens wear, air pollution increase the weight of, its sickness rate rises further.Therefore, correct understanding anaphylaxis conjunctivitis rational use of drug is significant.Anaphylaxis conjunctivitis is the conjunctiva anaphylaxis because contact hypersensitivity antigen causes, all people that is that have heredity to specific antigen or susceptible constitutionally, when contacting this antigen, anaphylactic type or delayed-type hypersensitivity membranous conjunctivitis can be caused, often with allergic rhinitis etc.The same with all anaphylactic diseases, anaphylaxis conjunctivitis be the conjunctival mucosa contact tissue of eyes after anaphylactogen, occur in the mode of eye conjunctivitis disease.And the material causing the anaphylactogen of anaphylaxis conjunctivitis very easily to enter eyes with pollen, dust, clammy air, dirt demodicid mite, animal hair etc. is in the majority, secondly be exactly normal and that eye is close perfume, cosmetics, medicine, contact lens and conditioning liquid thereof etc., these anaphylactogens enter eyes, a conjunctiva mastocyte is caused to discharge the sensitizing factors such as histamine, and these sensitizing factors make local telangiectasis, thus eye is caused to produce symptom that is red, that swell, itch.

The traditional Chinese medical science thinks that primary disease is many because of ailment said due to cold or exposure invasion and attack, and meridians are obstructed; Or accumulate damp and hot in taste, feel ailment said due to cold or exposure again, rheumatism pathogenic heat is stopped up in order; Or liver blood loses few, blood deficiency is pneumatic and cause.Tcm diagnosis is following several types:

(1) ailment said due to cold or exposure invasion and attack

Syndrome: ophthalmic pruritus, outer invisible disease, vision can't harm, and pale tongue with thin fur is white, floating pulse;

Discrimination: 1. dialectical: with ophthalmic pruritus, floating pulse is dialectical main points; 2. pathogenesis: ailment said due to cold or exposure is attacked, objective in order key event ophthalmic pruritus, the outer invisible disease of first susceptible evil event, normal visual acuity, resembling as levying of attacking outside ailment said due to cold or exposure of tongue lung.

(2) wind heat stops up order

Syndrome: ophthalmic pruritus is scorching hot, often in outbreak in spring, the cobble shape as paved the way in eyelid, meet wind heat, Exposure to Sunlight, smoked burn after, aggravation, red tongue, floating and rapid pulse;

Discrimination: 1. dialectical: scorching hot with ophthalmic pruritus, spring recurs, as cobble shape granule changes into dialectical main points in eyelid; 2. pathogenesis: attack outside wind heat, on stop up in order then ophthalmic pruritus, eye network blocks, and QI and blood is not all right, the cobble shape as paved the way in eyelid, wind heat for suffering from, therefore often because of wind heat, smokedly to burn, Exposure to Sunlight and pathological changes increases the weight of.

(3) damp-heat in the spleen and stomach is held concurrently by ailment said due to cold or exposure

Card marquis: eye is very itched unbearably, a lot of mucopurulent secretion in the eye, and born of the same parents' eyelid is heavy, xanthosis of the conjunctiva, red tongue greasy fur, slippery and rapid pulse;

Discrimination: 1. dialectical: very to itch with eye, born of the same parents' eyelid is heavy, and xanthosis of the conjunctiva is dialectical main points; 2. pathogenesis: wind heat damp is combined into trouble, therefore eye is very itched unbearably, mucopurulent secretion of the eyes like glue, damp pathogen being heavy and turbid in nature, therefore born of the same parents' eyelid is heavy, white of the eye is muddy, and it is damp and hot levying that tongue feeling pulse resembles.

(4) wind syndrome due to blood-deficiency

Card marquis: ophthalmic pruritus gesture is light, time when doing only, outer invisible disease, body is unreal, light red tongue thready pulse;

Discrimination: 1. dialectical: light with ophthalmic pruritus, time when doing only, body is unreal is dialectical main points; 2. pathogenesis: deficiency of liver-blood is few, stirring-up of pathogenic wind in the interior resulting from deficiency, therefore ophthalmic pruritus gesture is light, time when doing only, body is unreal, and tongue feeling pulse resembles and is not enough levying.

(5) liver lung is damp and hot

Syndrome: To Be Protected from Heat for ophthalmic pruritus, has roe shape glue sample granule to swell around black eyeball, white of the eye is dirty, and heat or moist ophthalmic pruritus increase the weight of, and red tongue tongue is greasy in vain, rapid pulse;

Discrimination: 1. dialectical: To Be Protected from Heat with ophthalmic pruritus, around black eyeball, roe shape glue sample protuberance is dialectical main points; 2. pathogenesis: cornea and iris associating with kidney, white of the eye belongs to lung, attacks on liver lung is damp and hot, then To Be Protected from Heat for ophthalmic pruritus, has roe shape glue sample to swell around black eyeball, and white of the eye is dirty, and wet wets or heat can help evil in suffering from, therefore ophthalmic pruritus increases the weight of, and tongue feeling pulse resembles as damp and hot is levied.

Chinese patent application 201410572362.8 discloses a kind of Chinese medicine preparation being used for the treatment of anaphylaxis conjunctivitis, this Chinese medicine preparation is prepared from by following raw material: Herba Ephedrae, the Fructus Kochiae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Flos Lonicerae, Cortex Dictamni, Herba Agrimoniae, Herba Equiseti Hiemalis, Herba Cyperi Iriae, the Radix Angelicae Dahuricae, Caulis Polygoni Multiflori, Fructus Cnidii, Herba Polygoni Avicularis, Ramulus et Folium Bauhiniae Faberi, Radix Cynanchi Paniculati, Nidus Vespae, Herba Hyperici Sampsonii, Herba Taxilli, Radix Talini Paniculati, Herba Centipedae, Rhizoma Polygonati Odorati, Herba Liparidis nervosae, Lindernia ruellioides (Colsm.) Pennell and Radix Glycyrrhizae, and this Chinese medicine preparation has effect for the treatment of anaphylaxis conjunctivitis.

Summary of the invention

Goal of the invention of the present invention is to provide a kind of Chinese medicine composition for the treatment of anaphylaxis conjunctivitis, this Chinese medicine composition has clearing away heat and expelling wind, promoting blood circulation, effect of loose wind dehumidifying, also have that preparation technology is easy, efficacy stability, universality are strong, be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this Chinese medicine composition.

For achieving the above object, the technical solution used in the present invention is:

Treat a Chinese medicine composition for anaphylaxis conjunctivitis, be prepared from by the raw material of following parts by weight:

Herba Portulacae 8-14 part, Radix Sophorae Flavescentis 6-10 part, Rhizoma Coptidis 4-12 part, Radix Rehmanniae 5-10 part, Radix Aconiti 2-8 part, Fructus Forsythiae 6-15 part, Cortex Dictamni 2-10 part, Fructus Leonuri 2-8 part, Flos Chrysanthemi 4-10 part, Fructus Atriplicis Sibiricae 2-6 part, Caulis Akebiae 4-8 part, Semen Cassiae 4-10 part and Radix Glycyrrhizae 1-10 part.

Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

Herba Portulacae 8 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Coptidis 4 parts, 5 parts, the Radix Rehmanniae, Radix Aconiti 2 parts, Fructus Forsythiae 6 parts, Cortex Dictamni 2 parts, Fructus Leonuri 2 parts, Flos Chrysanthemi 4 parts, Fructus Atriplicis Sibiricae 2 parts, Caulis Akebiae 4 parts, Semen Cassiae 4 parts and 1 part, Radix Glycyrrhizae.

Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

Herba Portulacae 14 parts, Radix Sophorae Flavescentis 10 parts, Rhizoma Coptidis 12 parts, 10 parts, the Radix Rehmanniae, Radix Aconiti 8 parts, Fructus Forsythiae 15 parts, Cortex Dictamni 10 parts, Fructus Leonuri 8 parts, Flos Chrysanthemi 10 parts, Fructus Atriplicis Sibiricae 6 parts, Caulis Akebiae 8 parts, Semen Cassiae 10 parts and 10 parts, Radix Glycyrrhizae.

Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

Herba Portulacae 10 parts, Radix Sophorae Flavescentis 8 parts, Rhizoma Coptidis 8 parts, 7 parts, the Radix Rehmanniae, Radix Aconiti 5 parts, Fructus Forsythiae 7 parts, Cortex Dictamni 6 parts, Fructus Leonuri 5 parts, Flos Chrysanthemi 7 parts, Fructus Atriplicis Sibiricae 4 parts, Caulis Akebiae 6 parts, Semen Cassiae 7 parts and 6 parts, Radix Glycyrrhizae.

Described Chinese medicine composition can be made into tablet, powder, capsule, granule or pill.

Accordingly, the preparation method of described Chinese medicine composition comprises following step:

(1): get Herba Portulacae, wash away impurity, crushed after being dried, cross 60-80 mesh sieve, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 240-300W, and Extracting temperature is 40-60 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;

(2): get Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae, Cortex Dictamni, Fructus Leonuri, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae, Semen Cassiae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge Herba Portulacae medicinal residues, add the water of coarse powder total amount 15-20 times amount, soak 20-30 minute, reflux, extract, 2-3 time, each 1-3 hour, filter, merging filtrate, the extractum that relative density is 1.10-1.20 is surveyed at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter and retain filtering residue, obtain filtrate A,

(3): the filtering residue obtained in (2) slowly being added while stirring its weight 4-6 times amount volume fraction is the ethanol of 40-60%, 4 DEG C of standing 3-5 hour, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;

(4): merging filtrate A, liquor B and cleaning mixture, survey extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;

(5): extractum obtained in Herba portulacae extract and (4) is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine composition of the present invention.

Source, the nature and flavor of Chinese medicine composition of the present invention Chinese crude drug used, return through and effect:

Herba Portulacae: this product is the dry aerial parts of portulacaceous plant Herba Portulacae; Sour in the mouth, cold in nature; Return liver, large intestine channel; Removing toxic substances, inhibiting bacteria and diminishing inflammation, diuresis dysentery relieving, intestine moistening disappear stagnant, debug, improving eyesight and suppression metrorrhagia.

Radix Sophorae Flavescentis: this product is the dry root of leguminous plant Radix Sophorae Flavescentis; Bitter in the mouth, cold in nature; GUIXIN, liver, stomach, large intestine, urinary bladder channel; Heat clearing and damp drying, parasite killing, diuresis.

Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis; Bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.

The Radix Rehmanniae: this product is the tuber of Scrophulariaceae Radix Rehmanniae platymiscium Radix Rehmanniae; Sweet in the mouth, hardship, cold in nature; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, matter profit is fallen and is let out.

Radix Aconiti: this product is the tuber of ranunculaceae plant Aconitum carmichjaelii Debx.; Acrid in the mouth, hot in nature; GUIXIN, liver,spleen,kidney warp; Expelling wind and removing dampness, warming the meridian, dispersing cold for relieving pain.

Fructus Forsythiae: this product is the dry fruit of Oleaceae plants Fructus Forsythiae; Bitter in the mouth, cold nature; Return lung, the heart, small intestine meridian; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.

Cortex Dictamni: this product is the dry root bark of rutaceae shaggy-fruited dittany; Bitter in the mouth, cold in nature; Return spleen, stomach, urinary bladder channel; Heat clearing and damp drying, removing toxic substances of dispeling the wind.

Fructus Leonuri: this product is the dry mature fruit of labiate Herba Leonuri; Acrid in the mouth, hardship, cold nature; GUIXIN bag, Liver Channel; Promoting blood flow to regulate menstruation, liver heat removing and eyesight improving.

Flos Chrysanthemi: this product is the dry capitulum of feverfew chrysanthemum; Sweet in the mouth, hardship, cold nature; Return lung, Liver Channel; Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.

Fructus Atriplicis Sibiricae: this product is the dry mature fruit of zygophyllaceae plant Fructus Tribuli; Bitter in the mouth, warm in nature; Return Liver Channel; Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic, dehumidifying, eliminating carbuncle.

Caulis Akebiae: this product is the woody stems of plants of Lardizabalaceae Caulis Akebiae or threeleaf akebia, Caulis Akebiae; Bitter in the mouth, cool in nature; Enter the heart, small intestinal, urinary bladder channel; Pathogenic fire purging row water, promoting blood circulation.

Semen Cassiae: this product is the dry mature seed of leguminous plant Semen Cassiae; Sweet in the mouth, hardship, salty, cold nature; Return liver, large intestine channel; Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

The prescription analysis of medicament composing prescription of the present invention:

According to the traditional Chinese medical science to the compatibility theory with the dialectical and Chinese crude drug for the treatment of anaphylaxis conjunctivitis effect, in conjunction with the body constitution of modern and the feature of modern pharmaceutical technology, the collocation ingredients of reasonable science, forms Chinese prescription of the present invention.Medicament composing prescription of the present invention with Herba Portulacae, Radix Sophorae Flavescentis and Rhizoma Coptidis for monarch drug, inhibiting bacteria and diminishing inflammation, heat clearing and damp drying, eliminating fire and detoxication; With the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae and Cortex Dictamni for ministerial drug, YIN nourishing and the production of body fluid promoting, dispersing swelling and dissipating binds, removing toxic substances of dispeling the wind; With Fructus Leonuri, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae and Semen Cassiae for adjuvant drug, liver heat removing and eyesight improving, loose wind heat clearing away, promoting blood circulation; With Radix Glycyrrhizae for making medicine, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, all medicines are arranged in pairs or groups, and synergism, reaches inhibiting bacteria and diminishing inflammation jointly, eliminating fire and detoxication, effect of liver heat removing and eyesight improving, has very significant therapeutic effect to anaphylaxis conjunctivitis.

The present invention also discloses a kind of purposes of above-mentioned Chinese medicine composition, i.e. the application of above-mentioned Chinese medicine composition in preparation treatment anaphylaxis conjunctivitis medicine.The clinical experimental study result display of Chinese medicine composition of the present invention, the cure rate more than 80.0% of pharmaceutical composition of the present invention, total effective rate more than 85.0%, higher than cure rate and the total effective rate of matched group, visible, the good effect of pharmaceutical composition of the present invention, cure rate is high, can be used as the drug use for the treatment of anaphylaxis conjunctivitis.

Compared with prior art, Chinese medicine composition provided by the invention has following beneficial effect:

1, Chinese medicine composition provided by the invention is in treatment anaphylaxis conjunctivitis, has significant curative effect, especially has clearing away heat and expelling wind, promoting blood circulation, effect of loose wind dehumidifying.

2, compared with the chemotherapeutic agent of Current therapeutic anaphylaxis conjunctivitis, Chinese medicine composition provided by the invention is natural pure Chinese medicinal preparation, the untoward reaction that minimizing stimulating intestine and stomach causes and side effect, and Chinese medicine composition effect provided by the invention is comprehensive, medication effect is better.

3, Chinese medicine composition provided by the invention has treating both the principal and secondary aspects of a disease, conditioning and the advantage that combines for the treatment of, and not easily recurs, and in addition, also has that preparation technology is easy, low cost and other advantages.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

the preparation of embodiment 1 present composition granule

Embodiment 1 Chinese medicine composition is prepared from by the raw material of following parts by weight:

Herba Portulacae 8 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Coptidis 4 parts, 5 parts, the Radix Rehmanniae, Radix Aconiti 2 parts, Fructus Forsythiae 6 parts, Cortex Dictamni 2 parts, Fructus Leonuri 2 parts, Flos Chrysanthemi 4 parts, Fructus Atriplicis Sibiricae 2 parts, Caulis Akebiae 4 parts, Semen Cassiae 4 parts and 1 part, Radix Glycyrrhizae.

Preparation method is as follows:

(1): get Herba Portulacae, wash away impurity, crushed after being dried, cross 60 mesh sieves, adding medical material gross weight 8 times amount volume fraction is the ethanol of 60%, microwave extraction 8 minutes, microwave power is 240W, and Extracting temperature is 40 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;

(2): get Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae, Cortex Dictamni, Fructus Leonuri, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae, Semen Cassiae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge Herba Portulacae medicinal residues, add the water of coarse powder total amount 15 times amount, soak 20 minutes, reflux, extract, 2 times, each 1 hour, filter, merging filtrate, surveys the extractum that relative density is 1.10-1.20 at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40%, 4 DEG C leave standstill 12 hours, filter and retain filtering residue, obtaining filtrate A;

(3): the filtering residue obtained in (2) slowly being added while stirring its weight 4 times amount volume fraction is the ethanol of 40%, 4 DEG C leave standstill 3 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2 times of 40% again, collects and merges cleaning mixture;

(4): merging filtrate A, liquor B and cleaning mixture, survey extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;

(5): extractum obtained in Herba portulacae extract and (4) is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, after drying, dry extract is pulverized, cross 100 mesh sieves, obtain Chinese medicine composition of the present invention;

(6): in above-mentioned Chinese medicine composition, add the filler Icing Sugar of equivalent, wetting agent distilled water, disintegrating agent hydroxypropyl starch and lubricant Pulvis Talci; mix homogeneously; obtain soft material processed; soft material processed is put into rotary extrusion type granulator; obtain wet granular, dry, cross 20 mesh sieve removing big particles; make uniform particles, obtain Chinese medicinal composition granules of the present invention.

the preparation of embodiment 2 present composition granule

Embodiment 2 Chinese medicine composition is prepared from by the raw material of following parts by weight:

Herba Portulacae 14 parts, Radix Sophorae Flavescentis 10 parts, Rhizoma Coptidis 12 parts, 10 parts, the Radix Rehmanniae, Radix Aconiti 8 parts, Fructus Forsythiae 15 parts, Cortex Dictamni 10 parts, Fructus Leonuri 8 parts, Flos Chrysanthemi 10 parts, Fructus Atriplicis Sibiricae 6 parts, Caulis Akebiae 8 parts, Semen Cassiae 10 parts and 10 parts, Radix Glycyrrhizae.Preparation method is with embodiment 1.

the preparation of embodiment 3 present composition powder

Embodiment 3 Chinese medicine composition is prepared from by the raw material of following parts by weight:

Herba Portulacae 10 parts, Radix Sophorae Flavescentis 8 parts, Rhizoma Coptidis 8 parts, 7 parts, the Radix Rehmanniae, Radix Aconiti 5 parts, Fructus Forsythiae 7 parts, Cortex Dictamni 6 parts, Fructus Leonuri 5 parts, Flos Chrysanthemi 7 parts, Fructus Atriplicis Sibiricae 4 parts, Caulis Akebiae 6 parts, Semen Cassiae 7 parts and 6 parts, Radix Glycyrrhizae.

Preparation method is as follows:

(1): get Herba Portulacae, wash away impurity, crushed after being dried, cross 80 mesh sieves, adding medical material gross weight 10 times amount volume fraction is the ethanol of 80%, microwave extraction 15 minutes, microwave power is 300W, and Extracting temperature is 60 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;

(2): get Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae, Cortex Dictamni, Fructus Leonuri, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae, Semen Cassiae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge Herba Portulacae medicinal residues, add the water of coarse powder total amount 20 times amount, soak 30 minutes, reflux, extract, 3 times, each 3 hours, filter, merging filtrate, surveys the extractum that relative density is 1.10-1.20 at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 60%, 4 DEG C leave standstill 24 hours, filter and retain filtering residue, obtaining filtrate A;

(3): the filtering residue obtained in (2) slowly being added while stirring its weight 6 times amount volume fraction is the ethanol of 60%, 4 DEG C leave standstill 5 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 3 times of 60% again, collects and merges cleaning mixture;

(4): merging filtrate A, liquor B and cleaning mixture, survey extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;

(5): extractum obtained in Herba portulacae extract and (4) is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, after drying, dry extract is pulverized, cross 200 mesh sieves, obtain Chinese medicine composition of the present invention;

(6): in above-mentioned Chinese medicine composition, add suitable adjuvant, mix homogeneously, sieve, Chinese medicine composition composition powders of the present invention is obtained.

clinical observation on the therapeutic effect

1, case selection: in 640 routine anaphylaxis conjunctivitis clinical volunteers patients, man 400 example, female 240 example, at minimum 12 years old of age, maximum 67 years old, all patients all met anaphylaxis conjunctivitis symptom.

2, tcm diagnosis:

(1) eye is very itched unbearably, the puckery discomfort of gritty, very then photophobia, shed tears;

(2) examination of eyes, palpebral conjunctiva type is shown in that upper tarsal conjunctiva is congested dirty, and loose nipple is the arrangement of paving stone shape, does not invade vault

Gallery portion conjunctiva, chou membranous type, conjunctiva is dirty congested, and be common in fissura palpebrae portion, limbus of corneae becomes sallow coloring agent sample to swell, and the visible cornea point-like of severe patient is muddy, very then corneal ulcer.Gum is white, haircuts shape;

(3) periodic flare, spring falls ill, and summer increases the weight of, and the autumn and winter are alleviated, and have spontaneous recovery to tend to;

(4) the visible oxyphil cell of conjunctiva scraping blade or acidophilic granule;

(5) common child and teenager, male is more, normal eyes morbidity;

(6) person of having ready conditions does sensitinogen inspection.

3, criterion of therapeutical effect:

Cure: angle conjunctive disorder disappears, ophthalmic pruritus is eliminated;

Take a turn for the better: angle conjunctive disorder is alleviated, and ophthalmic pruritus alleviates;

Do not heal: angle conjunctive disorder, ophthalmic pruritus are all without improvement;

Total effective rate=(curing number+improvement number)/total number of persons * 100%.

4, instructions of taking: 640 patients are divided into 4 groups at random, often organize 160 people, be respectively treatment A group, treatment B group, treatment C group and matched group, treatment A group takes the granule that the embodiment of the present invention 1 prepares, every day 3 times, each 2g, treatment B group takes the granule that the embodiment of the present invention 2 prepares, every day 3 times, each 2g, treatment C group takes the powder that the embodiment of the present invention 3 prepares, every day 3 times, each 2g, matched group takes the improving eyesight Fructus Tribuli ball of commercial type, a 9g, 2 times on the one, takes 2 weeks respectively.

5, therapeutic outcome:

Table 1 therapeutic outcome

This experiment contrast group improving eyesight Fructus Tribuli ball Main Ingredients and Appearance is Fructus Tribuli (saline is processed), Flos Chrysanthemi, Radix Rehmanniae, Radix Angelicae Sinensis, Fructus Viticis (micro-stir-fry), Flos Buddlejae, Pin thief, Semen Cassiae (stir-fry), Periostracum Cicadae, Rhizoma Coptidis, Radix Scutellariae, Herba Schizonepetae, Flos Inulae, Fructus Gardeniae (Jiang Shui processs), Concha Haliotidis, Rhizoma Chuanxiong, Cortex Phellodendri, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Menthae, Fructus Forsythiae, Radix Paeoniae Rubra, Radix Glycyrrhizae; There is effect of clearing away heat to dispel wind, improving acuity of vision and removing nebula.As shown in Table 1, the cure rate of pharmaceutical composition of the present invention reaches more than 80.0%, total effective rate reaches more than 85.0%, higher than cure rate and the total effective rate of matched group, wherein best with the therapeutic effect for the treatment of C group, visible, the good effect of pharmaceutical composition of the present invention, cure rate is high, can be used as the drug use for the treatment of anaphylaxis conjunctivitis.

Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.

Claims (7)

1. treat the Chinese medicine composition of anaphylaxis conjunctivitis for one kind, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Herba Portulacae 8-14 part, Radix Sophorae Flavescentis 6-10 part, Rhizoma Coptidis 4-12 part, Radix Rehmanniae 5-10 part, Radix Aconiti 2-8 part, Fructus Forsythiae 6-15 part, Cortex Dictamni 2-10 part, Fructus Leonuri 2-8 part, Flos Chrysanthemi 4-10 part, Fructus Atriplicis Sibiricae 2-6 part, Caulis Akebiae 4-8 part, Semen Cassiae 4-10 part and Radix Glycyrrhizae 1-10 part.

2. the Chinese medicine composition for the treatment of anaphylaxis conjunctivitis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Herba Portulacae 8 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Coptidis 4 parts, 5 parts, the Radix Rehmanniae, Radix Aconiti 2 parts, Fructus Forsythiae 6 parts, Cortex Dictamni 2 parts, Fructus Leonuri 2 parts, Flos Chrysanthemi 4 parts, Fructus Atriplicis Sibiricae 2 parts, Caulis Akebiae 4 parts, Semen Cassiae 4 parts and 1 part, Radix Glycyrrhizae.

3. the Chinese medicine composition for the treatment of anaphylaxis conjunctivitis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Herba Portulacae 14 parts, Radix Sophorae Flavescentis 10 parts, Rhizoma Coptidis 12 parts, 10 parts, the Radix Rehmanniae, Radix Aconiti 8 parts, Fructus Forsythiae 15 parts, Cortex Dictamni 10 parts, Fructus Leonuri 8 parts, Flos Chrysanthemi 10 parts, Fructus Atriplicis Sibiricae 6 parts, Caulis Akebiae 8 parts, Semen Cassiae 10 parts and 10 parts, Radix Glycyrrhizae.

4. the Chinese medicine composition for the treatment of anaphylaxis conjunctivitis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Herba Portulacae 10 parts, Radix Sophorae Flavescentis 8 parts, Rhizoma Coptidis 8 parts, 7 parts, the Radix Rehmanniae, Radix Aconiti 5 parts, Fructus Forsythiae 7 parts, Cortex Dictamni 6 parts, Fructus Leonuri 5 parts, Flos Chrysanthemi 7 parts, Fructus Atriplicis Sibiricae 4 parts, Caulis Akebiae 6 parts, Semen Cassiae 7 parts and 6 parts, Radix Glycyrrhizae.

5. the Chinese medicine composition of the treatment anaphylaxis conjunctivitis as described in any one of claim 1-4, is characterized in that: described Chinese medicine composition is made into tablet, powder, capsule, granule or pill.

6. a preparation method for the Chinese medicine composition of the treatment anaphylaxis conjunctivitis as described in any one of claim 1-4, is characterized in that, the preparation method of described Chinese medicine composition comprises following step:

(1): get Herba Portulacae, wash away impurity, crushed after being dried, cross 60-80 mesh sieve, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 240-300W, and Extracting temperature is 40-60 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;

(2): get Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae, Cortex Dictamni, Fructus Leonuri, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae, Semen Cassiae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge Herba Portulacae medicinal residues, add the water of coarse powder total amount 15-20 times amount, soak 20-30 minute, reflux, extract, 2-3 time, each 1-3 hour, filter, merging filtrate, the extractum that relative density is 1.10-1.20 is surveyed at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter and retain filtering residue, obtain filtrate A,

(3): the filtering residue obtained in (2) slowly being added while stirring its weight 4-6 times amount volume fraction is the ethanol of 40-60%, 4 DEG C of standing 3-5 hour, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;

(4): merging filtrate A, liquor B and cleaning mixture, survey extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;

(5): extractum obtained in Herba portulacae extract and (4) is merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, material strip transfer rate is 28cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine composition of the present invention.

7. the application of Chinese medicine composition according to claim 1 in preparation treatment anaphylaxis conjunctivitis medicine.