CN105147851A - Chinese herb composition for treating allergic conjunctivitis and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of Chinese medicine, and relates to a Chinese herb composition for treating allergic conjunctivitis and a preparation method thereof. The Chinese herb composition is prepared from, by weight, 8-18 parts of milkvetch roots, 10-20 parts of mulberry leaves, 8-16 parts of radix puerariae, 4-8 parts of dandelions, 4-8 parts of sophora flavescens, 2-6 parts of coptis chinensis, 6-14 parts of rehmannia rhizomes, 4-8 parts of aconite roots, 6-14 parts of forsythia suspensa, 2-6 parts of mint, 6-12 parts of chrysanthemums, 8-12 parts of tribulus terrestris, 2-6 parts of akebia stems, 4-8 parts of angelica roots, 10-15 parts of cassia seeds and 8-16 parts of liquorice roots. The Chinese herb composition has the obvious treatment advantages that the treatment effect is good, both symptoms and root causes are treated, conditioning and treating are combined, and relapse is not likely to occur, and further has the technical advantages that the preparation technology is simple and convenient to implement, the medicine effect is stable, generality is good, and application and popularization are easy.

Description

A kind of Chinese medicine composition for the treatment of anaphylaxis conjunctivitis and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of anaphylaxis conjunctivitis and preparation method thereof.

Background technology

Allergic ophthalmopathy is one of modal eye surface diseases, and wherein anaphylaxis conjunctivitis is modal type.According to statistics, about have the people of more than 5% to go to a doctor because of allergic ophthalmopathy in the world, and wherein the ratio of anaphylaxis conjunctivitis is more than 50%, in recent years, due to factors such as eye cosmetic use, contact lens wear, air pollution increase the weight of, its sickness rate rises further.Therefore, correct understanding anaphylaxis conjunctivitis rational use of drug is significant.Anaphylaxis conjunctivitis is the conjunctiva anaphylaxis because contact hypersensitivity antigen causes, all people that is that have heredity to specific antigen or susceptible constitutionally, when contacting this antigen, anaphylactic type or delayed-type hypersensitivity membranous conjunctivitis can be caused, often with allergic rhinitis etc.The same with all anaphylactic diseases, anaphylaxis conjunctivitis be the conjunctival mucosa contact tissue of eyes after anaphylactogen, occur in the mode of eye conjunctivitis disease.And the material causing the anaphylactogen of anaphylaxis conjunctivitis very easily to enter eyes with pollen, dust, clammy air, dirt demodicid mite, animal hair etc. is in the majority, secondly be exactly normal and that eye is close perfume, cosmetics, medicine, contact lens and conditioning liquid thereof etc., these anaphylactogens enter eyes, a conjunctiva mastocyte is caused to discharge the sensitizing factors such as histamine, and these sensitizing factors make local telangiectasis, thus eye is caused to produce symptom that is red, that swell, itch.

The traditional Chinese medical science thinks that primary disease is many because of ailment said due to cold or exposure invasion and attack, and meridians are obstructed; Or accumulate damp and hot in taste, feel ailment said due to cold or exposure again, rheumatism pathogenic heat is stopped up in order; Or liver blood loses few, blood deficiency is pneumatic and cause.Tcm diagnosis is following several types:

(1) ailment said due to cold or exposure invasion and attack

Syndrome: ophthalmic pruritus, outer invisible disease, vision can't harm, and pale tongue with thin fur is white, floating pulse;

Discrimination: 1. dialectical: with ophthalmic pruritus, floating pulse is dialectical main points; 2. pathogenesis: ailment said due to cold or exposure is attacked, objective in order key event ophthalmic pruritus, the outer invisible disease of first susceptible evil event, normal visual acuity, resembling as levying of attacking outside ailment said due to cold or exposure of tongue lung.

(2) wind heat stops up order

Syndrome: ophthalmic pruritus is scorching hot, often in outbreak in spring, the cobble shape as paved the way in eyelid, meet wind heat, Exposure to Sunlight, smoked burn after, aggravation, red tongue, floating and rapid pulse;

Discrimination: 1. dialectical: scorching hot with ophthalmic pruritus, spring recurs, as cobble shape granule changes into dialectical main points in eyelid; 2. pathogenesis: attack outside wind heat, on stop up in order then ophthalmic pruritus, eye network blocks, and QI and blood is not all right, the cobble shape as paved the way in eyelid, wind heat for suffering from, therefore often because of wind heat, smokedly to burn, Exposure to Sunlight and pathological changes increases the weight of.

(3) damp-heat in the spleen and stomach is held concurrently by ailment said due to cold or exposure

Card marquis: eye is very itched unbearably, a lot of mucopurulent secretion in the eye, and born of the same parents' eyelid is heavy, xanthosis of the conjunctiva, red tongue greasy fur, slippery and rapid pulse;

Discrimination: 1. dialectical: very to itch with eye, born of the same parents' eyelid is heavy, and xanthosis of the conjunctiva is dialectical main points; 2. pathogenesis: wind heat damp is combined into trouble, therefore eye is very itched unbearably, mucopurulent secretion of the eyes like glue, damp pathogen being heavy and turbid in nature, therefore born of the same parents' eyelid is heavy, white of the eye is muddy, and it is damp and hot levying that tongue feeling pulse resembles.

(4) wind syndrome due to blood-deficiency

Card marquis: ophthalmic pruritus gesture is light, time when doing only, outer invisible disease, body is unreal, light red tongue thready pulse;

Discrimination: 1. dialectical: light with ophthalmic pruritus, time when doing only, body is unreal is dialectical main points; 2. pathogenesis: deficiency of liver-blood is few, stirring-up of pathogenic wind in the interior resulting from deficiency, therefore ophthalmic pruritus gesture is light, time when doing only, body is unreal, and tongue feeling pulse resembles and is not enough levying.

(5) liver lung is damp and hot

Syndrome: To Be Protected from Heat for ophthalmic pruritus, has roe shape glue sample granule to swell around black eyeball, white of the eye is dirty, and heat or moist ophthalmic pruritus increase the weight of, and red tongue tongue is greasy in vain, rapid pulse;

Discrimination: 1. dialectical: To Be Protected from Heat with ophthalmic pruritus, around black eyeball, roe shape glue sample protuberance is dialectical main points; 2. pathogenesis: cornea and iris associating with kidney, white of the eye belongs to lung, attacks on liver lung is damp and hot, then To Be Protected from Heat for ophthalmic pruritus, has roe shape glue sample to swell around black eyeball, and white of the eye is dirty, and wet wets or heat can help evil in suffering from, therefore ophthalmic pruritus increases the weight of, and tongue feeling pulse resembles as damp and hot is levied.

Chinese patent application 201410572362.8 discloses a kind of Chinese medicine preparation being used for the treatment of anaphylaxis conjunctivitis, this Chinese medicine preparation is prepared from by following raw material: Herba Ephedrae, the Fructus Kochiae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Flos Lonicerae, Cortex Dictamni, Herba Agrimoniae, Herba Equiseti Hiemalis, Herba Cyperi Iriae, the Radix Angelicae Dahuricae, Caulis Polygoni Multiflori, Fructus Cnidii, Herba Polygoni Avicularis, Ramulus et Folium Bauhiniae Faberi, Radix Cynanchi Paniculati, Nidus Vespae, Herba Hyperici Sampsonii, Herba Taxilli, Radix Talini Paniculati, Herba Centipedae, Rhizoma Polygonati Odorati, Herba Liparidis nervosae, Lindernia ruellioides (Colsm.) Pennell and Radix Glycyrrhizae, and this Chinese medicine preparation has effect for the treatment of anaphylaxis conjunctivitis.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of anaphylaxis conjunctivitis, this Chinese medicine composition has clearing away heat and expelling wind, promoting blood circulation, effect of loose wind dehumidifying, also have that preparation technology is easy, efficacy stability, universality are strong, be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this Chinese medicine composition.

Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight:

Radix Astragali 8-18 part, Folium Mori 10-20 part, Radix Puerariae 8-16 part, Herba Taraxaci 4-8 part, Radix Sophorae Flavescentis 4-8 part, Rhizoma Coptidis 2-6 part, Radix Rehmanniae 6-14 part, Radix Aconiti 4-8 part, Fructus Forsythiae 6-14 part, Herba Menthae 2-6 part, Flos Chrysanthemi 6-12 part, Fructus Atriplicis Sibiricae 8-12 part, Caulis Akebiae 2-6 part, Radix Angelicae Dahuricae 4-8 part, Semen Cassiae 10-15 part and Radix Glycyrrhizae 8-16 part.

Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

The Radix Astragali 8 parts, 10 parts, Folium Mori, Radix Puerariae 8 parts, Herba Taraxaci 4 parts, Radix Sophorae Flavescentis 4 parts, Rhizoma Coptidis 2 parts, 6 parts, the Radix Rehmanniae, Radix Aconiti 4 parts, Fructus Forsythiae 6 parts, Herba Menthae 2 parts, Flos Chrysanthemi 6 parts, Fructus Atriplicis Sibiricae 8 parts, Caulis Akebiae 2 parts, the Radix Angelicae Dahuricae 4 parts, Semen Cassiae 10 parts and 8 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

The Radix Astragali 18 parts, 20 parts, Folium Mori, Radix Puerariae 16 parts, Herba Taraxaci 8 parts, Radix Sophorae Flavescentis 8 parts, Rhizoma Coptidis 6 parts, 14 parts, the Radix Rehmanniae, Radix Aconiti 8 parts, Fructus Forsythiae 14 parts, Herba Menthae 6 parts, Flos Chrysanthemi 12 parts, Fructus Atriplicis Sibiricae 12 parts, Caulis Akebiae 6 parts, the Radix Angelicae Dahuricae 8 parts, Semen Cassiae 15 parts and 16 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

The Radix Astragali 14 parts, 14 parts, Folium Mori, Radix Puerariae 12 parts, Herba Taraxaci 6 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Coptidis 4 parts, 10 parts, the Radix Rehmanniae, Radix Aconiti 6 parts, Fructus Forsythiae 12 parts, Herba Menthae 4 parts, Flos Chrysanthemi 8 parts, Fructus Atriplicis Sibiricae 10 parts, Caulis Akebiae 5 parts, the Radix Angelicae Dahuricae 6 parts, Semen Cassiae 12 parts and 14 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is made into tablet, powder, capsule, granule or pill.

Accordingly, the preparation method of described Chinese medicine composition comprises following step:

S1 gets Folium Mori, washes away impurity, 60 DEG C of hot air dryings 4 hours, and control moisture is 3-8%, pulverizes, and crosses 40-60 mesh sieve, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;

S2 gets the Radix Astragali, Radix Puerariae, Herba Taraxaci, Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae, Herba Menthae, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae, the Radix Angelicae Dahuricae, Semen Cassiae and Radix Glycyrrhizae and is pulverized and mixed, add above-mentioned coarse powder weight 4-6 times soak by water 2-3 hour, decoct 2-3 time, filter and retain filtering residue, merging filtrate, being concentrated into 60-70 DEG C of relative density through filtrate is the concentrated solution of 1.20-1.25;

S3 gets the filtering residue that step S2 obtains, and adding above-mentioned filtering residue 2-4 times weight concentration is the ethanol of 65-75%, extracts 1-2 time, each 1-3 hour, filters, merging filtrate, by filtrate decompression distillation removing ethanol, and to be concentrated into 60-70 DEG C of relative density be the concentrated solution of 1.20-1.25;

The concentrated solution that the Ultra-fine Powder of Mulberry Leaves that step S1 obtains by S4 and step S2 obtain and the concentrated solution that step S3 obtains mix, and being concentrated into 60-70 DEG C of relative density after mix homogeneously is the Chinese medical concrete of 1.30-1.35, to obtain final product.

Source, the nature and flavor of the present invention's component used, return through and effect:

The Radix Astragali: this product is the root of leguminous plant Radix Hedysari multijugi; Sweet in the mouth, warm in nature; GUIXIN, lung, spleen, kidney channel; Invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing.

Folium Mori: this product is the dried leaves of moraceae plants Mulberry.Bitter in the mouth, sweet, cold nature; Return lung, Liver Channel; Wind and heat dispersing, liver heat removing and eyesight improving, cooling blood for hemostasis.

Radix Puerariae: this product is the dry root of legume pueraria lobata or Radix Puerariae rattan.Sweet in the mouth, pungent; Cool in nature.Return spleen, stomach warp.Expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal, for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quenches one's thirst, measles without adequate eruption, and hematodiarrhoea, has loose bowels; Hypertension neck pain.

Herba Taraxaci: this product is the dry herb of feverfew Herba Taraxaci; Bitter but sweet flavor, cold in nature; Return liver, stomach warp; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.

Radix Sophorae Flavescentis: this product is the dry root of leguminous plant Radix Sophorae Flavescentis; Bitter in the mouth, cold in nature; GUIXIN, liver, stomach, large intestine, urinary bladder channel; Heat clearing and damp drying, parasite killing, diuresis.

Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis; Bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.

The Radix Rehmanniae: this product is the tuber of Scrophulariaceae Radix Rehmanniae platymiscium Radix Rehmanniae; Sweet in the mouth, hardship, cold in nature; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, matter profit is fallen and is let out.

Radix Aconiti: this product is the tuber of ranunculaceae plant Aconitum carmichjaelii Debx.; Acrid in the mouth, hot in nature; GUIXIN, liver,spleen,kidney warp; Expelling wind and removing dampness, warming the meridian, dispersing cold for relieving pain.

Fructus Forsythiae: this product is the dry fruit of Oleaceae plants Fructus Forsythiae; Bitter in the mouth, cold nature; Return lung, the heart, small intestine meridian; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.

Herba Menthae: this product is the dry aerial parts of Labiatae mint Herba Menthae; Acrid in the mouth, cool in nature; Return lung, Liver Channel; Dispelling wind-heat.

Flos Chrysanthemi: this product is the dry capitulum of feverfew chrysanthemum; Sweet in the mouth, hardship, cold nature; Return lung, Liver Channel; Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.

Fructus Atriplicis Sibiricae: this product is the dry mature fruit of zygophyllaceae plant Fructus Tribuli; Bitter in the mouth, warm in nature; Return Liver Channel; Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic, dehumidifying, eliminating carbuncle.

Caulis Akebiae: this product is the woody stems of plants of Lardizabalaceae Caulis Akebiae or threeleaf akebia, Caulis Akebiae; Bitter in the mouth, cool in nature; Enter the heart, small intestinal, urinary bladder channel; Pathogenic fire purging row water, promoting blood circulation.

The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae; Acrid in the mouth, warm in nature; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.

Semen Cassiae: this product is the dry mature seed of leguminous plant Semen Cassiae; Sweet in the mouth, hardship, salty, cold nature; Return liver, large intestine channel; Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Compared with prior art, Chinese medicine composition of the present invention has following technical advantage:

1, Chinese medicine composition of the present invention is in treatment anaphylaxis conjunctivitis, has significant curative effect, especially has clearing away heat and expelling wind, promoting blood circulation, effect of loose wind dehumidifying.

2, compared with the chemotherapeutic agent of Current therapeutic anaphylaxis conjunctivitis, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, the untoward reaction that minimizing stimulating intestine and stomach causes and side effect, and Chinese medicine composition effect of the present invention is comprehensive, and medication effect is better.

3, Chinese medicine composition of the present invention has treating both the principal and secondary aspects of a disease, conditioning and the advantage that combines for the treatment of, and not easily recurs, and in addition, also has that preparation technology is easy, low cost and other advantages.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

embodiment 1:

The embodiment of the present invention 1 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 8 parts, 10 parts, Folium Mori, Radix Puerariae 8 parts, Herba Taraxaci 4 parts, Radix Sophorae Flavescentis 4 parts, Rhizoma Coptidis 2 parts, 6 parts, the Radix Rehmanniae, Radix Aconiti 4 parts, Fructus Forsythiae 6 parts, Herba Menthae 2 parts, Flos Chrysanthemi 6 parts, Fructus Atriplicis Sibiricae 8 parts, Caulis Akebiae 2 parts, the Radix Angelicae Dahuricae 4 parts, Semen Cassiae 10 parts and 8 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1 gets Folium Mori, washes away impurity, 60 DEG C of hot air dryings 4 hours, and controlling moisture is 3%, pulverizes, and crosses 40 mesh sieves, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;

S2 gets the Radix Astragali, Radix Puerariae, Herba Taraxaci, Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae, Herba Menthae, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae, the Radix Angelicae Dahuricae, Semen Cassiae and Radix Glycyrrhizae and is pulverized and mixed, add above-mentioned coarse powder weight 4 times of soak by water 2 hours, decoct 2 times, filter and retain filtering residue, merging filtrate, being concentrated into 60 DEG C of relative densities through filtrate is the concentrated solution of 1.20;

S3 gets the filtering residue that step S2 obtains, and adding above-mentioned filtering residue 2 times of weight concentrations is the ethanol of 65%, extracts 1 time, each 1 hour, filters, merging filtrate, and by filtrate decompression distillation removing ethanol, and to be concentrated into 60 DEG C of relative densities be the concentrated solution of 1.20;

The concentrated solution that the Ultra-fine Powder of Mulberry Leaves that step S1 obtains by S4 and step S2 obtain and step S3 concentrated solution mix, and being concentrated into 60 DEG C of relative densities after mix homogeneously is the Chinese medical concrete of 1.30, adds corresponding adjuvant, makes granule.

embodiment 2:

The embodiment of the present invention 2 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 18 parts, 20 parts, Folium Mori, Radix Puerariae 16 parts, Herba Taraxaci 8 parts, Radix Sophorae Flavescentis 8 parts, Rhizoma Coptidis 6 parts, 14 parts, the Radix Rehmanniae, Radix Aconiti 8 parts, Fructus Forsythiae 14 parts, Herba Menthae 6 parts, Flos Chrysanthemi 12 parts, Fructus Atriplicis Sibiricae 12 parts, Caulis Akebiae 6 parts, the Radix Angelicae Dahuricae 8 parts, Semen Cassiae 15 parts and 16 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1 gets Folium Mori, washes away impurity, 60 DEG C of hot air dryings 4 hours, and controlling moisture is 5%, pulverizes, and crosses 50 mesh sieves, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;

S2 gets the Radix Astragali, Radix Puerariae, Herba Taraxaci, Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae, Herba Menthae, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae, the Radix Angelicae Dahuricae, Semen Cassiae and Radix Glycyrrhizae and is pulverized and mixed, add above-mentioned coarse powder weight 5 times of soak by water 2 hours, decoct 2 times, filter and retain filtering residue, merging filtrate, being concentrated into 65 DEG C of relative densities through filtrate is the concentrated solution of 1.23;

S3 gets the filtering residue that step S2 obtains, and adding above-mentioned filtering residue 3 times of weight concentrations is the ethanol of 70%, extracts 1 time, each 1 hour, filters, merging filtrate, and by filtrate decompression distillation removing ethanol, and to be concentrated into 65 DEG C of relative densities be the concentrated solution of 1.23;

The concentrated solution that the Ultra-fine Powder of Mulberry Leaves that step S1 obtains by S4 and step S2 obtain and step S3 concentrated solution mix, and being concentrated into 65 DEG C of relative densities after mix homogeneously is the Chinese medical concrete of 1.32, adds corresponding adjuvant, makes tablet.

embodiment 3:

The embodiment of the present invention 3 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 14 parts, 14 parts, Folium Mori, Radix Puerariae 12 parts, Herba Taraxaci 6 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Coptidis 4 parts, 10 parts, the Radix Rehmanniae, Radix Aconiti 6 parts, Fructus Forsythiae 12 parts, Herba Menthae 4 parts, Flos Chrysanthemi 8 parts, Fructus Atriplicis Sibiricae 10 parts, Caulis Akebiae 5 parts, the Radix Angelicae Dahuricae 6 parts, Semen Cassiae 12 parts and 14 parts, Radix Glycyrrhizae.

Preparation method is as follows:

S1 gets Folium Mori, washes away impurity, 60 DEG C of hot air dryings 4 hours, and controlling moisture is 8%, pulverizes, and crosses 60 mesh sieves, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;

S2 gets the Radix Astragali, Radix Puerariae, Herba Taraxaci, Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae, Herba Menthae, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae, the Radix Angelicae Dahuricae, Semen Cassiae and Radix Glycyrrhizae and is pulverized and mixed, add above-mentioned coarse powder weight 6 times of soak by water 3 hours, decoct 3 times, filter and retain filtering residue, merging filtrate, being concentrated into 70 DEG C of relative densities through filtrate is the concentrated solution of 1.25;

S3 gets the filtering residue that step S2 obtains, and adding above-mentioned filtering residue 4 times of weight concentrations is the ethanol of 75%, extracts 2 times, each 3 hours, filters, merging filtrate, and by filtrate decompression distillation removing ethanol, and to be concentrated into 70 DEG C of relative densities be the concentrated solution of 1.25;

The concentrated solution that the Ultra-fine Powder of Mulberry Leaves that step S1 obtains by S4 and step S2 obtain and step S3 concentrated solution mix, and being concentrated into 70 DEG C of relative densities after mix homogeneously is the Chinese medical concrete of 1.35, adds corresponding adjuvant, makes pill.

clinical observation on the therapeutic effect

1, case selection: in 300 routine anaphylaxis conjunctivitis clinical volunteers patients, man 180 example, female 120 example, at minimum 10 years old of age, maximum 70 years old, all patients all met anaphylaxis conjunctivitis symptom.

2, tcm diagnosis:

(1) eye is very itched unbearably, the puckery discomfort of gritty, very then photophobia, shed tears;

(2) examination of eyes, palpebral conjunctiva type is shown in that upper tarsal conjunctiva is congested dirty, and loose nipple is the arrangement of paving stone shape, does not invade vault

Gallery portion conjunctiva, chou membranous type, conjunctiva is dirty congested, and be common in fissura palpebrae portion, limbus of corneae becomes sallow coloring agent sample to swell, and the visible cornea point-like of severe patient is muddy, very then corneal ulcer.Gum is white, haircuts shape;

(3) periodic flare, spring falls ill, and summer increases the weight of, and the autumn and winter are alleviated, and have spontaneous recovery to tend to;

(4) the visible oxyphil cell of conjunctiva scraping blade or acidophilic granule;

(5) common child and teenager, male is more, normal eyes morbidity;

(6) person of having ready conditions does sensitinogen inspection.

3, criterion of therapeutical effect:

Cure: angle conjunctive disorder disappears, ophthalmic pruritus is eliminated;

Take a turn for the better: angle conjunctive disorder is alleviated, and ophthalmic pruritus alleviates;

Do not heal: angle conjunctive disorder, ophthalmic pruritus are all without improvement;

Total effective rate=(curing number+improvement number)/total number of persons * 100%.

4, instructions of taking: 300 patients are divided into 4 groups at random, be respectively treatment A group, treatment B group, treatment C group and matched group, treatment A group takes the granule that the embodiment of the present invention 1 prepares, every day 3 times, each 2g, treatment B group takes tablet prepared by the embodiment of the present invention 2, every day 3 times, each 2g, treatment C group takes pill prepared by the embodiment of the present invention 3, every day 3 times, each 2g, matched group takes the improving eyesight Fructus Tribuli ball of commercial type, a 9g, 2 times on the one, take 2 weeks respectively.

5, therapeutic outcome:

table 1 therapeutic outcome

This experiment contrast group improving eyesight Fructus Tribuli ball Main Ingredients and Appearance is Fructus Tribuli (saline is processed), Flos Chrysanthemi, Radix Rehmanniae, Radix Angelicae Sinensis, Fructus Viticis (micro-stir-fry), Flos Buddlejae, Pin thief, Semen Cassiae (stir-fry), Periostracum Cicadae, Rhizoma Coptidis, Radix Scutellariae, Herba Schizonepetae, Flos Inulae, Fructus Gardeniae (Jiang Shui processs), Concha Haliotidis, Rhizoma Chuanxiong, Cortex Phellodendri, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Menthae, Fructus Forsythiae, Radix Paeoniae Rubra, Radix Glycyrrhizae; There is effect of clearing away heat to dispel wind, improving acuity of vision and removing nebula.As shown in Table 1, the cure rate of pharmaceutical composition of the present invention reaches more than 80.0%, and total effective rate reaches more than 90.0%, and higher than cure rate and the total effective rate of matched group, the therapeutic effect of wherein treating C group is best.Visible, the good effect of pharmaceutical composition of the present invention, cure rate is high, can be used as the drug use for the treatment of anaphylaxis conjunctivitis.

Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.

Claims (6)

1. treat a Chinese medicine composition for anaphylaxis conjunctivitis, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

Radix Astragali 8-18 part, Folium Mori 10-20 part, Radix Puerariae 8-16 part, Herba Taraxaci 4-8 part, Radix Sophorae Flavescentis 4-8 part, Rhizoma Coptidis 2-6 part, Radix Rehmanniae 6-14 part, Radix Aconiti 4-8 part, Fructus Forsythiae 6-14 part, Herba Menthae 2-6 part, Flos Chrysanthemi 6-12 part, Fructus Atriplicis Sibiricae 8-12 part, Caulis Akebiae 2-6 part, Radix Angelicae Dahuricae 4-8 part, Semen Cassiae 10-15 part and Radix Glycyrrhizae 8-16 part.

2. the Chinese medicine composition for the treatment of anaphylaxis conjunctivitis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

The Radix Astragali 8 parts, 10 parts, Folium Mori, Radix Puerariae 8 parts, Herba Taraxaci 4 parts, Radix Sophorae Flavescentis 4 parts, Rhizoma Coptidis 2 parts, 6 parts, the Radix Rehmanniae, Radix Aconiti 4 parts, Fructus Forsythiae 6 parts, Herba Menthae 2 parts, Flos Chrysanthemi 6 parts, Fructus Atriplicis Sibiricae 8 parts, Caulis Akebiae 2 parts, the Radix Angelicae Dahuricae 4 parts, Semen Cassiae 10 parts and 8 parts, Radix Glycyrrhizae.

3. the Chinese medicine composition for the treatment of anaphylaxis conjunctivitis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

The Radix Astragali 18 parts, 20 parts, Folium Mori, Radix Puerariae 16 parts, Herba Taraxaci 8 parts, Radix Sophorae Flavescentis 8 parts, Rhizoma Coptidis 6 parts, 14 parts, the Radix Rehmanniae, Radix Aconiti 8 parts, Fructus Forsythiae 14 parts, Herba Menthae 6 parts, Flos Chrysanthemi 12 parts, Fructus Atriplicis Sibiricae 12 parts, Caulis Akebiae 6 parts, the Radix Angelicae Dahuricae 8 parts, Semen Cassiae 15 parts and 16 parts, Radix Glycyrrhizae.

4. the Chinese medicine composition for the treatment of anaphylaxis conjunctivitis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight:

The Radix Astragali 14 parts, 14 parts, Folium Mori, Radix Puerariae 12 parts, Herba Taraxaci 6 parts, Radix Sophorae Flavescentis 6 parts, Rhizoma Coptidis 4 parts, 10 parts, the Radix Rehmanniae, Radix Aconiti 6 parts, Fructus Forsythiae 12 parts, Herba Menthae 4 parts, Flos Chrysanthemi 8 parts, Fructus Atriplicis Sibiricae 10 parts, Caulis Akebiae 5 parts, the Radix Angelicae Dahuricae 6 parts, Semen Cassiae 12 parts and 14 parts, Radix Glycyrrhizae.

5. the Chinese medicine composition for the treatment of anaphylaxis conjunctivitis as claimed in claim 1, it is characterized in that, described Chinese medicine composition is made into tablet, powder, capsule, granule or pill.

6. the preparation method of the Chinese medicine composition of the treatment anaphylaxis conjunctivitis as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises following step:

S1 gets Folium Mori, washes away impurity, 60 DEG C of hot air dryings 4 hours, and control moisture is 3-8%, pulverizes, and crosses 40-60 mesh sieve, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;

S2 gets the Radix Astragali, Radix Puerariae, Herba Taraxaci, Radix Sophorae Flavescentis, Rhizoma Coptidis, the Radix Rehmanniae, Radix Aconiti, Fructus Forsythiae, Herba Menthae, Flos Chrysanthemi, Fructus Atriplicis Sibiricae, Caulis Akebiae, the Radix Angelicae Dahuricae, Semen Cassiae and Radix Glycyrrhizae and is pulverized and mixed, add above-mentioned coarse powder weight 4-6 times soak by water 2-3 hour, decoct 2-3 time, filter and retain filtering residue, merging filtrate, being concentrated into 60-70 DEG C of relative density through filtrate is the concentrated solution of 1.20-1.25;

S3 gets the filtering residue that step S2 obtains, and adding above-mentioned filtering residue 2-4 times weight concentration is the ethanol of 65-75%, extracts 1-2 time, each 1-3 hour, filters, merging filtrate, by filtrate decompression distillation removing ethanol, and to be concentrated into 60-70 DEG C of relative density be the concentrated solution of 1.20-1.25;

The concentrated solution that the Ultra-fine Powder of Mulberry Leaves that step S1 obtains by S4 and step S2 obtain and the concentrated solution that step S3 obtains mix, and being concentrated into 60-70 DEG C of relative density after mix homogeneously is the Chinese medical concrete of 1.30-1.35, to obtain final product.