CN112586646A - Solid beverage with eyesight protecting and asthenopia relieving functions and preparation method thereof - Google Patents

Solid beverage with eyesight protecting and asthenopia relieving functions and preparation method thereof Download PDF

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Publication number
CN112586646A
CN112586646A CN202010131311.7A CN202010131311A CN112586646A CN 112586646 A CN112586646 A CN 112586646A CN 202010131311 A CN202010131311 A CN 202010131311A CN 112586646 A CN112586646 A CN 112586646A
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parts
extract
powder
ethanol
oligosaccharide
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Inventor
谢超
谢晓亮
贾东升
崔施展
温春秀
魏曼
成玉婷
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Hebei Kangping Health Industry Co ltd
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Hebei Kangping Health Industry Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
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Abstract

The invention provides a solid beverage with the functions of protecting eyesight and relieving asthenopia and a preparation method thereof, and the pharmaceutical composition with the function of protecting eyesight comprises the following raw materials in parts by weight: 15-25 parts of cassia seed extract, 15-25 parts of marigold extract, 15-25 parts of kudzu root extract, 15-25 parts of cowberry fruit extract, 16-24 parts of chrysanthemum extract, 0.1-0.8 part of medlar oligosaccharide, 0.1-0.5 part of vitamin A and 0.1-0.5 part of beta-carotene. The pharmaceutical composition provided by the invention has the effects of treating photophobia, eye soreness, lacrimation and eye spasm symptoms, has the effects of improving eye nutrition, relieving research fatigue and the like, and also has various medicinal effects of spasmolysis, anti-inflammation, blood pressure reduction, prevention of cardiovascular and cerebrovascular diseases and the like, and enriches the medicinal functions.

Description

Solid beverage with eyesight protecting and asthenopia relieving functions and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a solid beverage capable of protecting eyesight and relieving eyestrain and a preparation method thereof.
Background
Eye fatigue becomes a common disease of contemporary people, and dry eyes, sour eyes, swollen eyes, blurred vision and even visual deterioration caused by the eye fatigue directly influence the work and life of people. The eyestrain is mainly caused by that people watch the screens of computers, televisions and mobile phones for a long time, the number of blinking is reduced, tear secretion is correspondingly reduced, and rays and radiation harm are caused. Young people in the multi-screen age are often in a tension state of over-fatigue of eyes, and unclear vision, myopia, dryness and swelling become common phenomena and are important manifestations of eye sub-health. The development of a product with the effects of protecting eyesight and providing eye nutrition has very important practical significance, and can help a user to enhance eye nutrition, protect eyesight and relieve eye fatigue.
The Chinese invention patent publication No. CN107519338A, entitled "a Chinese medicinal composition for protecting eyesight by external use", specifically discloses that the Chinese medicinal composition comprises the following raw material medicaments: the external application of the externally applied medicine on the periphery of eye sockets is matched with a physical therapy instrument, and the clinically detected medicine has obvious curative effects on visual fatigue symptoms such as visual disturbance, eye drowsiness, photophobia, ache, lacrimation, foreign body sensation, dry eye, eye spasm and the like.
The traditional Chinese medicine composition is prepared from a plurality of raw materials, mainly aiming at external stimulation, and is complex to prepare and produce, and the obtained traditional Chinese medicine composition has a single function and only has a simple effect of being applied to external stimulation of eyes so as to relieve symptoms; the effects of protecting eyesight, providing eye nutrition and relieving eye fatigue can not be achieved by oral administration and mechanically regulating and controlling various active ingredients; the raw materials and mechanisms adopted by external application and oral administration are completely different.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a pharmaceutical composition which realizes the mechanistic regulation of a plurality of active ingredients through oral administration, achieves the effects of protecting eyesight, providing eye nutrition and relieving eye fatigue and a preparation method thereof. Meanwhile, the composition is rich in various functional factors, and the functional effect of the pharmaceutical composition is enriched.
In order to achieve the purpose, the invention is realized by the following technical scheme:
the solid beverage with the functions of protecting eyesight and relieving asthenopia comprises the following raw materials in parts by weight: 15-25 parts of cassia seed extract, 15-25 parts of marigold extract, 15-25 parts of kudzu root extract, 15-25 parts of cowberry fruit extract, 16-24 parts of chrysanthemum extract, 0.1-0.8 part of medlar oligosaccharide, 0.1-0.5 part of vitamin A and 0.1-0.5 part of beta-carotene.
The refining process of the wolfberry oligosaccharide comprises the following steps:
s1, removing impurities: weighing 20 parts of coarse wolfberry powder according to parts by weight, wherein the mass ratio of the coarse wolfberry powder to the coarse wolfberry powder is M: adding 95% ethanol into the M ethanol 1:6, leaching for a period of time at the temperature of 40-50 ℃, filtering, and washing filter residues with 95% ethanol for three times;
s2, extraction: and (3) after the ethanol in the S1 medicine residues is volatilized, carrying out hot reflux water extraction, wherein the mass of the medicine residues: extracting with water M at a ratio of 1:10 under reflux for 2 times, each time for 1 hr, mixing the two extractive solutions, concentrating under reduced pressure to relative density of 1.06-1.08, and freeze drying to obtain lyophilized powder;
s3, macroporous resin purification: dissolving the lyophilized powder in S2 with appropriate amount of water, passing through HP-20 macroporous resin, eluting with 2 times column volume water, washing off monosaccharide, disaccharide, etc., eluting with 2 times column volume ethanol, washing off oligosaccharide components, mixing ethanol eluates, and concentrating under reduced pressure to dry to obtain fructus Lycii oligosaccharide extract.
Preferably, the pharmaceutical composition comprises the following raw materials in parts by weight: 20 parts of cassia seed extract, 20 parts of marigold extract, 20 parts of kudzu root extract, 20 parts of cowberry fruit extract, 19 parts of chrysanthemum extract, 0.5 part of medlar oligosaccharide, 0.2 part of vitamin A and 0.3 part of beta-carotene.
Preferably, the leaching time in the S1 is 12 h.
The preparation method of the solid beverage with the functions of protecting eyesight and relieving asthenopia comprises the following steps:
(1) weighing 50 parts of marigold, kudzu root and chrysanthemum respectively according to the parts by weight, mixing and crushing the materials into 30-mesh coarse powder, wherein the mass ratio of M coarse powder: adding 75% ethanol into 1:6, extracting at 40-50 deg.C for 2 hr, concentrating the extractive solution under reduced pressure to appropriate relative density, recovering ethanol, freeze drying, and pulverizing to obtain flos Tagetis Erectae extract powder;
(2) weighing 50 parts of each of semen cassiae and cowberry, adding water for extraction twice, adding 10 times of water for the first time, extracting for 2 hours at low temperature, filtering and separating residues, taking filtrate, adding 8 times of water for the second time, extracting for 1.5 hours at low temperature, combining the two filtrates to obtain mixed extract, and then extracting according to the weight ratio M: adding maltodextrin into the M maltodextrin at a ratio of 1:0.1, and spray drying to obtain semen Cassiae and cowberry fruit extract powder;
(3) weighing vitamin A and beta-carotene according to parts by weight, then adding the marigold extract powder, the cowberry extract powder and the medlar oligosaccharide, and uniformly mixing to obtain the cassia seed and marigold composition, namely the solid beverage with the functions of protecting eyesight and relieving asthenopia.
Preferably, the extract in the step (1) is concentrated under reduced pressure, and then has a relative density of 1.0 to 1.1.
Preferably, the low-temperature extraction temperature in the step (2) is 60-80 ℃.
The cassia seed is a traditional Chinese medicine food material, and contains active ingredients such as chrysophanol, emodin, cassia tora essence, aurantio-obtusin and vitamin A according to the record of a Chinese medicine dictionary. The cassia seed recorded in Chinese pharmacopoeia has the efficacies of clearing heat and improving eyesight, red eyes and unsmooth eyes and no clear eyes.
Kudzu vine root is a core medicinal material for improving eyesight and protecting liver, contains active ingredients such as puerarin, puerarin xyloside, soybean flavone, beta-sitosterol, arachidic acid and the like, and the modern researches on kudzu vine root's production of body fluid and thirst quenching, yang invigorating and diarrhea stopping, and meridian passage dredging are recorded in Chinese pharmacopoeia, show that the kudzu vine root flavonoid substances can increase the supply of blood to oxygen and relieve visual and physical fatigue.
Marigold is rich in lutein, is the main component of macula lutea in eyes, can prevent retinal macula aging, has ultraviolet filtering effect, and can prevent and treat ultraviolet injury to eyes and eyesight.
The cowberry fruit is rich in anthocyanin, and has effects of protecting capillary vessel, increasing regeneration of erythrocyte, and protecting eye and eyesight.
The oligosaccharide is oligosaccharide with lower polymerization degree, the polymerization degree of a glucoside chain is 2-20, the molecular weight is less than or equal to 3200Da, the water solubility is good, the oligosaccharide has stronger biological activity and is easy to absorb and utilize, and the oligosaccharide has better effects on reducing the blood pressure, the blood sugar and the blood sugar, preventing cardiovascular and cerebrovascular diseases and maintaining the function of retina.
Vitamin A has multiple physiological functions of promoting growth and reproduction, maintaining normal secretion of bones, epithelial tissues, eyesight and mucous epithelium, and the like, and has a protective effect on optic nerves.
Beta-carotene is an antioxidant. After the beta-carotene enters the body, 50% of the beta-carotene is changed into vitamin A under the action of enzyme in the liver and small intestine mucosa, has the functions of tonifying liver and improving eyesight, and can be used for treating nyctalopia; benefiting diaphragm and widening intestine. The beta-carotene can be converted into vitamin A after entering human body, and the conversion has adjustability.
The invention has the beneficial effects that:
the cassia seed is bitter, sweet and salty in taste and slightly cold in nature, enters liver, kidney and large intestine channels, and has the effects of clearing liver, improving vision, promoting diuresis, relaxing bowels, relieving diarrhea, lowering blood pressure and reducing blood fat. Marigold has tranquilizing, blood pressure lowering, bronchus dilating, spasmolytic and antiinflammatory effects. Semen Cassiae and flos Tagetis Erectae can be combined for clearing heat, improving eyesight, relieving asthenopia and reducing blood lipid. The cowberry fruit is rich in anthocyanin, protects capillary vessels, increases the regeneration of visual red cells, and can effectively protect eyes and eyesight. The lycium barbarum oligosaccharide has stronger biological activity, is easy to absorb and utilize, and has better effects of reducing high blood pressure, high blood sugar, high blood lipid, preventing cardiovascular and cerebrovascular diseases and maintaining the function of retina. The vitamin A can effectively improve the generation of the rhodopsin in the eyes and reduce the dryness degree of the eyes and the night blindness phenomenon. The solid beverage for protecting eyesight and relieving asthenopia has the advantages of fewer raw materials, simple synthesis process and reduced production cost, has the simple function of relieving asthenopia, also has various medicinal effects of spasmolysis, anti-inflammation, blood pressure reduction, cardiovascular and cerebrovascular disease prevention and the like, and enriches the medicinal functions.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the solid beverage with the functions of protecting eyesight and relieving asthenopia comprises the following raw materials in parts by weight: 15 parts of cassia seed extract, 15 parts of marigold extract, 15 parts of kudzu root extract, 15 parts of cowberry fruit extract, 16 parts of chrysanthemum extract, 0.8 part of medlar oligosaccharide, 0.1 part of vitamin A and 0.5 part of beta-carotene;
the refining process of the wolfberry oligosaccharide comprises the following steps:
s1, removing impurities: weighing 20 parts of coarse wolfberry powder according to parts by weight, wherein the mass ratio of the coarse wolfberry powder to the coarse wolfberry powder is M: adding 95% ethanol into the mixture with the ratio of M ethanol to 1:6, leaching for 12h at the temperature of 40 ℃, filtering, and washing filter residues with 95% ethanol for three times;
s2, extraction: and (3) after the ethanol in the S1 medicine residues is volatilized, carrying out hot reflux water extraction, wherein the mass of the medicine residues: extracting with water M at a ratio of 1:10 under reflux for 2 times, each time for 1 hr, mixing the two extractive solutions, concentrating under reduced pressure to relative density of 1.06-1.08, and freeze drying to obtain lyophilized powder;
s3, macroporous resin purification: dissolving the lyophilized powder in S2 with appropriate amount of water, passing through HP-20 macroporous resin, eluting with 2 times column volume water, washing off monosaccharide and disaccharide components, eluting with 2 times column volume ethanol, washing off oligosaccharide components, mixing ethanol eluates, and concentrating under reduced pressure to dry to obtain fructus Lycii oligosaccharide.
A preparation method of a solid beverage with the functions of protecting eyesight and relieving asthenopia comprises the following steps:
(1) weighing 50 parts of marigold, kudzu root and chrysanthemum respectively according to the parts by weight, mixing and crushing the materials into 30-mesh coarse powder, wherein the mass ratio of M coarse powder: adding 75% ethanol into the M ethanol 1:6, extracting for 2h at the temperature of 50 ℃, then taking an extracting solution, concentrating under reduced pressure until the relative density is 1.0-1.1, recovering ethanol, freeze-drying, and crushing to obtain marigold extract powder for later use;
(2) weighing 50 parts of each of semen cassiae and cowberry, adding water for extraction twice, adding water with the amount of 10 times of the material amount of the medicinal materials for the first time, extracting at low temperature, controlling the extraction temperature at 60 ℃ and the extraction time at 2h, filtering and separating residues, taking primary filtrate, adding water with the amount of 8 times of the residue for the second time, extracting at low temperature for 1.5h, combining the filtrates of the two times to obtain mixed extract, and then extracting according to the weight ratio M: adding maltodextrin into the M maltodextrin at a ratio of 1:0.1, and spray drying to obtain semen Cassiae and cowberry fruit extract powder;
(3) weighing vitamin A and beta-carotene according to parts by weight, then adding the marigold extract powder, the cowberry extract powder and the medlar oligosaccharide, and uniformly mixing to obtain the cassia seed and marigold composition, namely the solid beverage with the functions of protecting eyesight and relieving asthenopia.
Example 2:
the solid beverage with the functions of protecting eyesight and relieving asthenopia comprises the following raw materials in parts by weight: 25 parts of cassia seed extract, 25 parts of marigold extract, 25 parts of kudzu root extract, 25 parts of cowberry fruit extract, 24 parts of chrysanthemum extract, 0.1 part of medlar oligosaccharide, 0.5 part of vitamin A and 0.1 part of beta-carotene;
the refining process of the wolfberry oligosaccharide comprises the following steps:
s1, removing impurities: weighing 20 parts of coarse wolfberry powder according to parts by weight, wherein the mass ratio of the coarse wolfberry powder to the coarse wolfberry powder is M: adding 95% ethanol into the mixture with the ratio of M ethanol to 1:6, leaching for 12h at the temperature of 50 ℃, filtering, and washing filter residues with 95% ethanol for three times;
s2, extraction: and (3) after the ethanol in the S1 medicine residues is volatilized, carrying out hot reflux water extraction, wherein the mass of the medicine residues: extracting with water M at a ratio of 1:10 under reflux for 2 times, each time for 1 hr, mixing the two extractive solutions, concentrating under reduced pressure to relative density of 1.06-1.08, and freeze drying to obtain lyophilized powder;
s3, macroporous resin purification: dissolving the lyophilized powder in S2 with appropriate amount of water, passing through HP-20 macroporous resin, eluting with 2 times column volume water, washing off monosaccharide and disaccharide components, eluting with 2 times column volume ethanol, washing off oligosaccharide components, mixing ethanol eluates, and concentrating under reduced pressure to dry to obtain fructus Lycii oligosaccharide.
A preparation method of a solid beverage with the functions of protecting eyesight and relieving asthenopia comprises the following steps:
(1) weighing 50 parts of marigold, kudzu root and chrysanthemum respectively according to the parts by weight, mixing and crushing the materials into 30-mesh coarse powder, wherein the mass ratio of M coarse powder: adding 75% ethanol into the M ethanol 1:6, extracting for 2h at the temperature of 40 ℃, then taking an extracting solution, concentrating under reduced pressure until the relative density is 1.0-1.1, recovering ethanol, freeze-drying, and crushing to obtain marigold extract powder for later use;
(2) weighing 50 parts of each of semen cassiae and cowberry, adding water for extraction twice, adding water with the amount of 10 times of the material amount of the medicinal materials for the first time, extracting at low temperature, controlling the extraction temperature at 80 ℃ and the extraction time at 2h, filtering and separating residues, taking primary filtrate, adding water with the amount of 8 times of the residue for the second time, extracting at low temperature for 1.5h, combining the filtrates of the two times to obtain mixed extract, and then extracting according to the weight ratio M: adding maltodextrin into the M maltodextrin at a ratio of 1:0.1, and spray drying to obtain semen Cassiae and cowberry fruit extract powder;
(3) weighing vitamin A and beta-carotene according to parts by weight, then adding the marigold extract powder, the cowberry extract powder and the medlar oligosaccharide, and uniformly mixing to obtain the cassia seed and marigold composition, namely the solid beverage with the functions of protecting eyesight and relieving asthenopia.
Example 3:
the solid beverage with the functions of protecting eyesight and relieving asthenopia comprises the following raw materials in parts by weight: 20 parts of cassia seed extract, 20 parts of marigold extract, 20 parts of kudzu root extract, 20 parts of cowberry fruit extract, 19 parts of chrysanthemum extract, 0.5 part of medlar oligosaccharide, 0.2 part of vitamin A and 0.3 part of beta-carotene;
the refining process of the wolfberry oligosaccharide comprises the following steps:
s1, removing impurities: weighing 20 parts of coarse wolfberry powder according to parts by weight, wherein the mass ratio of the coarse wolfberry powder to the coarse wolfberry powder is M: adding 95% ethanol into the mixture with the ratio of M ethanol to 1:6, leaching for 12h at the temperature of 45 ℃, filtering, and washing filter residues with 95% ethanol for three times;
s2, extraction: and (3) after the ethanol in the S1 medicine residues is volatilized, carrying out hot reflux water extraction, wherein the mass of the medicine residues: extracting with water M at a ratio of 1:10 under reflux for 2 times, each time for 1 hr, mixing the two extractive solutions, concentrating under reduced pressure to relative density of 1.06-1.08, and freeze drying to obtain lyophilized powder;
s3, macroporous resin purification: dissolving the lyophilized powder in S2 with appropriate amount of water, passing through HP-20 macroporous resin, eluting with 2 times column volume water, washing off monosaccharide and disaccharide components, eluting with 2 times column volume ethanol, washing off oligosaccharide components, mixing ethanol eluates, and concentrating under reduced pressure to dry to obtain fructus Lycii oligosaccharide.
A preparation method of a solid beverage with the functions of protecting eyesight and relieving asthenopia comprises the following steps:
(1) weighing 50 parts of marigold, kudzu root and chrysanthemum respectively according to the parts by weight, mixing and crushing the materials into 30-mesh coarse powder, wherein the mass ratio of M coarse powder: adding 75% ethanol into the M ethanol 1:6, extracting for 2h at the temperature of 45 ℃, then taking an extracting solution, concentrating under reduced pressure until the relative density is 1.0-1.1, recovering ethanol, freeze-drying, and crushing to obtain marigold extract powder for later use;
(2) weighing 50 parts of each of semen cassiae and cowberry, adding water for extraction twice, adding water with the amount of 10 times of the material amount of the medicinal materials for the first time, extracting at low temperature, controlling the extraction temperature at 70 ℃ and the extraction time at 2h, filtering and separating residues, taking primary filtrate, adding water with the amount of 8 times of the residue for the second time, extracting at low temperature for 1.5h, combining the filtrates of the two times to obtain mixed extract, and then extracting according to the weight ratio M: adding maltodextrin into the M maltodextrin at a ratio of 1:0.1, and spray drying to obtain semen Cassiae and cowberry fruit extract powder;
(3) weighing vitamin A and beta-carotene according to parts by weight, then adding the marigold extract powder, the cowberry extract powder and the medlar oligosaccharide, and uniformly mixing to obtain the cassia seed and marigold composition, namely the solid beverage with the functions of protecting eyesight and relieving asthenopia.
Comparative example:
a Chinese medicinal composition taken from a comparison document CN 107519338A.
Experiment:
four patients, named Xuezao, male, age 44, with photophobia, soreness of the eyes, and lacrimation, took the medication of example 1 for 1 week.
Patient two, old, male, 45 years old, suffered from symptoms of eye spasm, eye soreness, and lacrimation, and took the medicine obtained in example 2 for 1 week.
Patient III, Wu-chi, female, age 45, with symptoms of eye spasm, photophobia, and lacrimation, took the medication obtained in example 3 for 1 week.
Patient four, wangzhi, woman, age 44, with symptoms of photophobia, eye soreness, lacrimation, took the drug from comparative example for 1 week.
The results are shown in Table 1:
TABLE 1
Patient's health Photophobia Soreness of the eyes Lacrimation Spasm of the eye
Patient one Disappearance of symptoms Disappearance of symptoms Disappearance of symptoms Is free of
Patient 2 Is free of Disappearance of symptoms Disappearance of symptoms Obvious improvement of symptoms
Patient three Disappearance of symptoms Is free of Disappearance of symptoms Obvious improvement of symptoms
Patient four Adapted only to weak light Has no obvious improvement Often lacrimate Is free of
According to the above experimental results, the pharmaceutical compositions obtained in examples 1 to 3 are significantly better than the traditional Chinese medicine compositions provided in the prior art for treating photophobia, ocular soreness, lacrimation and eye spasm.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (6)

1. The solid beverage with the functions of protecting eyesight and relieving asthenopia is characterized in that the pharmaceutical composition comprises the following raw materials in parts by weight: 15-25 parts of cassia seed extract, 15-25 parts of marigold extract, 15-25 parts of kudzu root extract, 15-25 parts of cowberry fruit extract, 16-24 parts of chrysanthemum extract, 0.1-0.8 part of medlar oligosaccharide, 0.1-0.5 part of vitamin A and 0.1-0.5 part of beta-carotene;
the refining process of the wolfberry oligosaccharide comprises the following steps:
s1, removing impurities: weighing 20 parts of coarse wolfberry powder according to parts by weight, wherein the mass ratio of the coarse wolfberry powder to the coarse wolfberry powder is M: adding 95% ethanol into the M ethanol 1:6, leaching for a period of time at the temperature of 40-50 ℃, filtering, and washing filter residues with 95% ethanol for three times;
s2, extraction: and (3) after the ethanol in the S1 medicine residues is volatilized, carrying out hot reflux water extraction, wherein the mass of the medicine residues: extracting with water M at a ratio of 1:10 under reflux for 2 times, each time for 1 hr, mixing the two extractive solutions, concentrating under reduced pressure to relative density of 1.06-1.08, and freeze drying to obtain lyophilized powder;
s3, macroporous resin purification: dissolving the lyophilized powder in S2 with appropriate amount of water, passing through HP-20 macroporous resin, eluting with 2 times column volume water, washing off monosaccharide and disaccharide components, eluting with 2 times column volume ethanol, washing off oligosaccharide components, mixing ethanol eluates, and concentrating under reduced pressure to dry to obtain fructus Lycii oligosaccharide extract.
2. The solid beverage for protecting eyesight and relieving asthenopia according to claim 1, wherein the pharmaceutical composition comprises the following raw materials in parts by weight: 20 parts of cassia seed extract, 20 parts of marigold extract, 20 parts of kudzu root extract, 20 parts of cowberry fruit extract, 19 parts of chrysanthemum extract, 0.5 part of medlar oligosaccharide, 0.2 part of vitamin A and 0.3 part of beta-carotene.
3. The solid beverage with eyesight protecting and asthenopia relieving effects of claim 1, wherein the leaching time in S1 is 12 h.
4. A method for preparing a solid beverage with eyesight protecting and asthenopia relieving effects according to any one of claims 1-3, which comprises the following steps:
(1) weighing 50 parts of marigold, kudzu root and chrysanthemum respectively according to the parts by weight, mixing and crushing the materials into 30-mesh coarse powder, wherein the mass ratio of M coarse powder: adding 75% ethanol into 1:6, extracting at 40-50 deg.C for 2 hr, concentrating the extractive solution under reduced pressure to appropriate relative density, recovering ethanol, freeze drying, and pulverizing to obtain flos Tagetis Erectae extract powder;
(2) weighing 50 parts of each of semen cassiae and cowberry, adding water for extraction twice, adding 10 times of water for the first time, extracting for 2 hours at low temperature, filtering and separating residues, taking filtrate, adding 8 times of water for the second time, extracting for 1.5 hours at low temperature, combining the two filtrates to obtain mixed extract, and then extracting according to the weight ratio M: adding maltodextrin into the M maltodextrin at a ratio of 1:0.1, and spray drying to obtain semen Cassiae and cowberry fruit extract powder;
(3) weighing vitamin A and beta-carotene according to parts by weight, then adding marigold extract powder, cowberry extract powder and medlar oligosaccharide, uniformly mixing, and granulating to obtain the cassia seed and marigold composition, namely the solid beverage with the functions of protecting eyesight and relieving asthenopia.
5. The method for preparing a solid beverage capable of protecting eyesight and relieving asthenopia according to claim 4, wherein the relative density of the extract in the step (1) after concentration under reduced pressure is 1.0-1.1.
6. The method for preparing a solid beverage with eyesight protecting and asthenopia relieving effects as claimed in claim 4, wherein the low temperature extraction temperature in the step (2) is 60-80 ℃.
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