CN105878573A - Composition for relieving visual fatigue - Google Patents

Composition for relieving visual fatigue Download PDF

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Publication number
CN105878573A
CN105878573A CN201610341057.7A CN201610341057A CN105878573A CN 105878573 A CN105878573 A CN 105878573A CN 201610341057 A CN201610341057 A CN 201610341057A CN 105878573 A CN105878573 A CN 105878573A
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extract
composition
cowberry
matrimony vine
preparation
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王义明
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a composition for relieving visual fatigue. The composition can be used as a medicine or as a functional food composition used for preventing or improving visual fatigue and can contain pharmaceutically acceptable carriers and effective quantities of raw material extracts, wherein the raw material extracts include cowberry or a cowberry extract, barbary wolfberry fruit or a barbary wolfberry fruit extract and lutein or an extract of flower of Aztec marigold. The composition has the function of preventing, improving or treating visual fatigue and the function of handling at least one of the symptoms including sore eyes, eye distension, photophobia, blurred vision and dry eyes and can achieve the effect of improving the duration of photopic vision. Prepared from pure natural medicinal and edible plant extracts, the composition is safe to use, does not have any toxic or side effect and has stable and controllable quality.

Description

A kind of composition for relieving asthenopia
Technical field
The present invention relates to a kind of composition for relieving asthenopia.
Background technology
Communication society, it is daily that the video display terminal (vdt) such as computer, television set, game machine has penetrated into us The every nook and cranny of life, user gets more and more；Adding study and work pressure big, social competition is the most sharp Strong so that a series of syndrome such as visual fatigue also gets more and more, they are deeply dry and astringent by eyes, foreign body sensation, eye Fatigue, eyelid sense of heaviness, blurred vision, photophobia are shed tears, eye distending pain, eye hyperemia and other eye disease Puzzlement.Severe patient it is also possible that headache, dizzy, feel sick, One's spirits are drooping, absent minded, note Recall power to decline, lose the appetite and the whole body disease such as neck shoulder aching pain in waist and back and articulations digitorum manus numbness, some patients There is also diplopia, stereoscopic vision dysfunction, intraocular pressure rising, corneal injury etc..
A statistics according to the World Health Organization, the whole world has 100,000,000 8 thousand ten thousand crowds to suffer from various types of eye Portion's disease.It is reported, in the experimenter carrying out conventional ophthalmic inspection with the presence of 10%～15% people with calculate The machine relevant headache of work and visual fatigue, have video display terminal (VDT) operator of about 33.5% to claim visual fatigue, And have the trend of growth.The existing people more than 800,000,000 of China wears glasses but also is increasing year by year, and sight protection is Through being instant problem, especially adolescent myopia.Therefore, there is expert call: increasingly sharpen is near The healthy commonplace problem of infringement Chinese Youth's has been become depending on rate, such as the control that do not takes effective measures, we " nationality worn glasses " will be become.One joint investigation of the Ministry of Education in 2006 and the Ministry of Public Health shows, China The rate of myopia of middle school student reaches 34.6%, and high school student's rate of myopia reaches 70%, and university student's rate of myopia is up to 83%, closely Ranking the first in the world depending on number of the infected, the incidence of disease is only second to Japan and occupies second place of the world.Therefore, have extensively Suitable population.In recent years, from conventional medicament and natural resources, new raw material is found by world wide The extensive attention of medical personal.
Summary of the invention
It is an object of the invention to provide one to be effective to prevention, improve or treat asthenopic composition.
The composition for relieving asthenopia that the present invention provides, including cowberry or Bilberry fruit P.E；Matrimony vine or matrimony vine Extract；And, lutein or Flos Tagetis Erectae extract.
Cowberry, is commonly called as blueberry, is a kind of perennial shrub, originates in Northern Europe, North America and Canada, is working as Use it for treating diabetes and the longest history of eye disease.Ripe cranberry is rich in flavonoids Pigment and the anthocyanidin as antibiotic.China cowberry rich in anthocyanidin, the coloring matter in cowberry anthocyanidin, Predominantly anthocyanidin-2-glucoside, anthocyanidin-3-xyloside, anthocyanidin-3-galactoside, anthocyanidin-2- Rhamnoside, delphinium-3-rhamnoside, delphinium-5-glucoside, the former delphinidin of 3-O-acyl, high mallow look Element-3,5-bioside etc..Bilberry fruit P.E, by improving oxygen and blood-transmitted to the ability of eye, improves eye merit Can, improve and alleviate visual fatigue.Healthy People or the alone Bilberry fruit P.E of vision disorder patient or take simultaneously β- Carrotene and vitamin E, can obviously improve night vision, very fast to dark reaction, and eye is exposed to light Afterwards, visual acuity can comparatively fast be recovered.Anthocyanidin is the elite extract of cowberry, can be effectively improved visual fatigue disease Shape, improves myopia and the distant vision of low myopia in early days.China scientist utilizes the flavones extracted from cowberry Some health foods that class anthocyanidin active principle is made, it is mainly composed of anthocyanidin, can increase ciliary muscle CBF, eliminates visual fatigue and related symptoms, improves eye microcirculation, promotes the regeneration of visual purple red pigment, carries The function of high optic cell, strengthens eye to the adaptability to changes of light intensity and dark adaptation ability.Improve because regarding The pseudo-myopia that fatigue causes, stops the development of low myopia, the antioxidation of anthocyanidin, can prevent eye Portion's lipid peroxidation, effectively removes the infringement of radical pair eyeball tissue.
Matrimony vine is the fruit of plant of Solanaceae lycium barbarum.Tcm health preserving theory thinks " liver opening at eye ".The most just It is to say, eyeshield liver to be protected simultaneously.Matrimony vine energy nourishing liver filling liver kidney, benefiting shrewd head.Cure mainly consumptive disease essence to lose, dizzy Dizzy tinnitus, blurred vision is failed to understand.As " book on Chinese herbal medicine converges and says " is recorded: " matrimony vine can make gas to fill, and blood can be mended, and sun can Raw, the moon can be grown, and rheumatism is dispelled, and here has perfect magical effect." wolfberry fruit extract brownish-yellow powder, easy moisture absorption, molten Yu Shui, it is mainly composed of LBP-X.This polysaccharide system proteoglycan, molecular weight is 22～25kD, by Ah Draw 6 kinds of monosaccharide components compositions such as uncle sugar, glucose, galactolipin, mannose, wood sugar, rhamnose.Matrimony vine Extract can effectively protect retinal ganglial cells；LBP-X can substantially Inhibition test crystalline lens oxidation Lens epithelial cell apoptosis caused by damage, protects eyesight, alleviates visual fatigue.
Lutein belongs to the one of carotenoid, jointly exists with luteole in nature.Marigold It it is plant the abundantest containing natural carotenol and luteole at present.Tagetes in composite family perennial plant, Containing natural carotenol, luteole, anthocyanidin, vitamin, mineral matter etc., these nutrients all cannot Human body synthesizes voluntarily, it is necessary to absorb from diet.
Lutein is water insoluble, is soluble in grease and fatty solvent.Pure lutein is that rib trellis yellow is brilliant Body, has metallic luster, unstable to light and hydrogen, need to be stored in the shady and cool place that is dried, lucifuge sealing, be to constitute The key component of the phytochromes such as corn, veterinary antibiotics, flowers, has protection to photooxidation, photo damage Effect.Also it is the primary pigments constituting human eye retina's macular region.Lutein can protect the eyes from light Infringement, delays eyes aging, prevents pathology.Lutein has expansion blood vessel and anti-oxidation function, can improve Eye microcirculation, improves eye nutrition supply, prevents the oxidative damage of radical pair eye, allows eyes obtain Sufficient blood supply, strengthens retina collagen structure, thus protects eyesight, alleviates visual fatigue.
The composition of the present invention is on the basis of Traditional Chinese medical theory and modern pharmacological research, and meticulous prescription forms, Lutein can protect macula retinae and improve eye microcirculation, is retina and class that crystalline lens uniquely exists One of carrotene；Theoretical " liver opening at eye " according to tcm health preserving, matrimony vine can be nourishing liver and kidney, benefiting shrewd head, Also liver can be protected while eyeshield；Bilberry fruit P.E improves oxygen and blood-transmitted to the abilities such as eye, raising eye Nutrition, can comparatively fast recover visual acuity simultaneously, and three acts synergistically from different perspectives, has reached to protect eyesight, Improving eye function, alleviate visual fatigue, its effect is better than folk prescription.
Bilberry fruit P.E, wolfberry fruit extract and Flos Tagetis Erectae extract all can directly buy commercial goods.Also may be used It is prepared by arbitrary extracting method known in the art.
Be exemplified below one preferably extracting method, can with fast and easy and high-purity extract Bilberry fruit P.E, Wolfberry fruit extract or Flos Tagetis Erectae extract:
1) raw material is at 10 DEG C to 80 DEG C, preferably carries out under room temperature (about 25 DEG C), preferably 1～3 day, carries Access method such as has hot water extracting, cold soaking to extract, returned cold is extracted or ultrasonically treated, and preferably cold soaking extracts 1～5 Secondary；The solvent extractable matter that filtration under diminished pressure obtains, at 20 DEG C to 100 DEG C, preferably under room temperature (about 25 DEG C), Utilize Rotary Evaporators reduced pressure concentration filtrate, thus obtain final extract.
Further, described step 1) in the carrying of Bilberry fruit P.E, wolfberry fruit extract or Flos Tagetis Erectae extract Taking solvent is water, C1～C4In alcohols, acetone, chloroform, dichloromethane, ether, ethyl acetate and hexane One or more.Wherein optimal with ethanol.
Further, described step 1) in the preparation method of Bilberry fruit P.E be: take cowberry dry fruit, wash Squeezing after clean, pressed liquor uses stainless steel mesh to filter, and filtrate water dilutes and is uniformly dispersed, obtaining cowberry Fruit pressed liquor；By cranberry pressed liquor Dynamic Adsorption in the AB-8 macroreticular resin pre-processed, first With water elution, elution flow rate is 60L/h, discards water elution liquid；Again with the ethanol of concentration expressed in percentage by volume 70% Wash-out, elution flow rate is 30L/h, collects ethanol eluate, obtains cowberry active component eluent；Gained Cowberry active component eluent be evaporated to relative density 1.05～1.20, then drying under reduced pressure, dried object powder Broken, obtain Bilberry fruit P.E.Wherein, the pretreatment of AB-8 macroreticular resin is according to the product of AB-8 macroreticular resin Product specification is carried out, and uses ethanol-water system activation process.
Further, described step 1) in the preparation method of wolfberry fruit extract be: matrimony vine is in the water of 85～95 DEG C Extracting twice, each 2 hours, extract uses stainless steel mesh to filter, and reduced pressure concentration after cooling concentrates Liquid adds ethanol, and adjusting ethanol concentration expressed in percentage by volume is 80%, obtains the 80% ethanol precipitated liquid of matrimony vine, heavy After the drying under reduced pressure of shallow lake, pulverize and make powder.
Further, described step 1) in the preparation method of Flos Tagetis Erectae extract be: marigold clean after through de- Marigold particles is made in water, drying, and in fermentation cylinder for fermentation, the marigold particles after fermenting is placed in The n-hexane of 55～65 DEG C leaches 1.5h, filters, by medicinal extract at 66～70 DEG C after pressurization recovery n-hexane Saponification 5～10h in KOH solution, filter, drying under reduced pressure, obtain Flos Tagetis Erectae extract.Marigold particles Fermentation strain is preferably used one or more in Lactobacillus plantarum, lactobacillus leichmannii or streptococcus thermophilus.
2) Bilberry fruit P.E, wolfberry fruit extract and Flos Tagetis Erectae extract all arbitrary can be had by known in the art Effect composition isolation and purification method carry out adsorption, including solvent segregation (liquid-liquid extraction), the precipitation method, Dialysis, chromatography etc..Wherein refining for Bilberry fruit P.E, first-selection is column chromatography, all fillers Can be the one or more combination in silica gel, polyamide or macroreticular resin, the most preferably macroreticular resin； Big pore resin can be the non-pole such as HPD100, HPD300, HPD700, D101, AB-8, X-5 Property or low pole macroporous type polymeric adsorbent, or the compound resin of Several combinations, the most preferably D101 macropore Polymeric adsorbent, this resin destroys minimum for cowberry active ingredient, it is possible to retain more active ingredient.
3) composition for relieving asthenopia described in any of the above, each Ingredient Amount is: cowberry or cowberry are extracted Thing 0.1～250 weight portion；Matrimony vine or wolfberry fruit extract 0.1～150 weight portion；Lutein or Flos Tagetis Erectae extract 0.1～200 weight portions.
Further, each Ingredient Amount is preferably: cowberry or Bilberry fruit P.E 120～220 weight portion；Matrimony vine or Wolfberry fruit extract 80～90 weight portion；Lutein or Flos Tagetis Erectae extract 110～200 weight portion.
Present invention also offers the composition for relieving asthenopia described in any of the above and alleviate asthenopic medicine Thing, health food for alleviating eye fatigue or alleviate the application in asthenopic beverage.
In terms of preparation is used for alleviating asthenopic medicine, the composition of the present invention can add and pharmaceutically can connect The carrier being subject to or additive, make any dosage form, preferred tablet, capsule, granule, powder, outstanding Supernatant liquid, emulsion, syrup, or oral formulations.
When making oral formulations, can be selected for diluent, lubricating oil, binding agent, disintegrant, sweetener, steady Determine one or more in agent and preservative as carrier, can be selected in flavoring agent, vitamin and antioxidant One or more as additive.Carrier and additive can be any pharmaceutically acceptable examples. In particular, it is preferred that diluent include: lactose, glucose, dextrin, sucrose, cornstarch, soya-bean oil, Microcrystalline cellulose, sorbierite, xylitol and mannitol, preferred lubricant includes magnesium stearate and talcum, Preferred binder includes polyvinylpyrrolidone or carboxy-propyl cellulose.Additionally, it is preferred that disintegrant include: Calcium carboxymethylcellulose, carboxyrnethyl starch sodium, polyacrylic acid potassium or Crospovidone, the example of preferred sweetener Including: white sugar, fructose, sorbierite or Aspartame, preferred stabilizer includes: sodium carboxymethylcellulose, Beta-schardinger dextrin, hundred beeswaxs and xanthans, preferred preservative includes: methyl p-hydroxybenzoate, to hydroxyl Propyl benzoate and potassium sorbate.In addition to these compositions, also can comprise and add for improving the known of taste Add agent, such as: natural flavouring, such as plum, lemon, pineapple or medicinal herbs taste.Fruit juice, natural Dyestuff, such as chlorophyllin or flavonoids, sweetener component, such as fructose, honey, sugar alcohol or sugar or Acidulant such as citric acid or sodium citrate.
During preparation Asthenopia-relievinghealthcare healthcare food, can be prepared as following form: powder, particle, Tablet, pill, capsule, suspension, emulsion, syrup, chewing gum, tea, jelly etc..Can in sitology The carrier or the additive that accept can be any carrier known in the art or additive.
When preparation is used for alleviating asthenopic beverage, except above-mentioned herbal ingredients, this beverage also can comprise it His component, other components described can be the various flavor enhancements or natural carbohydrate used in conventional beverage. The example of above-mentioned natural carbohydrate is conventional sugar, such as monose (such as glucose or fructose etc.), disaccharides (as Maltose, sucrose etc.) and polysaccharide (such as glucan, cyclodextrin etc.), and sugar alcohol, such as xylitol, sorb Alcohol and antierythrite.Also other flavor enhancements, natural flavouring can be added (such as thaumatin, STEVIA REBAUDIANA Extract etc.) and synthesis flavor enhancement (such as saccharin, Aspartame etc.).
Further, in above-mentioned application, when preparing Asthenopia-relievinghealthcare healthcare food, described combination The addition of thing accounts for the 0.01～15% of health food gross weight, preferably up to 0.2～10% weight；Preparation is used for delaying When solving asthenopic beverage, every 100ml beverage contains described composition 0.1～30g, preferably 0.2g to 5g.
The method have the advantages that
The composition of the present invention includes medicinal and edible plant extract, without any side effects, in prevention, changes Kind or treatment visual fatigue presents unexpected effect, including reply ophthalmodynia, eye is swollen, photophobia, regarding thing At least one symptom during fuzzy, eye is dry and astringent, can improve duration of photopic vision.
In order to weigh its to asthenopic mitigation, select long-term eye, the fatigable adult of eyesight, Once a day, each 2 payment capsules of being prepared from of above-mentioned composition, by visual fatigue situation interrogation, The metrics evaluation such as visuognosis persistence test and distant vision mensuration.Compared with placebo (control group), result Show ophthalmodynia, eye is swollen, photophobia, blurred vision, eye are dry and astringent etc., and clinical symptoms have improvement.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, so that those skilled in the art is permissible It is better understood from the present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
Embodiment 1 has the composition alleviating visual fatigue effect, and its preparation method comprises the following steps:
Step 1, the preparation of Bilberry fruit P.E: take cowberry dry fruit 20kg, squeeze after cleaning, pressed liquor Employing stainless steel mesh filters, and filtrate water dilutes and is uniformly dispersed, and obtains 30L cranberry pressed liquor； By cranberry pressed liquor Dynamic Adsorption in the AB-8 macroreticular resin pre-processed with ethanol water, first with 150L water elution, elution flow rate is 60L/h (1000ml/h), discards water elution liquid；Again with 120L 70% Ethanol (V/V) elutes, and elution flow rate is 30L/h (500ml/min), collects 70% ethanol eluate, To cowberry active component eluent；The cowberry active component eluent of gained is evaporated to relative density 1.05～1.20 (60 DEG C of mensuration), then at 60 DEG C of drying under reduced pressure, dried object is pulverized, is obtained the cowberry of the present invention Functional component group extract.
Step 2, the preparation of wolfberry fruit extract: choose matrimony vine, extraction twice in the water of 85～95 DEG C, every time 2 hours, extract used stainless steel mesh to filter, reduced pressure concentration after cooling, and concentrate uses and adds ethanol, Adjusting concentration of alcohol is 80% (concentration of volume percent), obtains the 80% ethanol precipitated liquid of matrimony vine, precipitation After drying under reduced pressure, pulverize and make powder, obtain the matrimony vine functional component group extract of the present invention.
Step 3, the preparation of Flos Tagetis Erectae extract: choose marigold clean after, through dehydration, dry make ten thousand Longevity chrysanthemum granules, with Lactobacillus plantarum, lactobacillus leichmannii and the mixed culture fermentation agent of streptococcus thermophilus in fermentation tank Carry out ferment (leavening inoculum concentration is the 0.1% of marigold particles quality), by the marigold particles after fermentation Being placed in the n-hexane of 55～65 DEG C leaching 1.5h, filter, lutein extract is existed after reclaiming n-hexane by pressurization Saponification 5～10h in the KOH solution of 66～70 DEG C, filter, drying under reduced pressure, obtain Flos Tagetis Erectae extract (main Wanting composition is lutein).
Embodiment 2 one kinds has the preparation of the medicinal granule of efficacy of relieving visual fatigue
The Bilberry fruit P.E powder 120g of preparation, Flos Tagetis Erectae extract 200g and matrimony vine in above-described embodiment 1 Extract 90g mixes, and adds dextrin 37g and magnesium stearate 3g, mixes, and making granularity is 16 mesh Drug particles, obtain the medicinal granule of the efficacy of relieving visual fatigue of the present invention.
Embodiment 3 one kinds has the preparation of the medicine capsule of efficacy of relieving visual fatigue
The Bilberry fruit P.E powder 220g of preparation, lutein 110g and wolfberry fruit extract in above-described embodiment 1 80g mixes, and adds dextrin 37g and magnesium stearate 3g, mixes, make the medicine that granularity is 16 mesh Grain, loads capsule, obtains the medicine capsule of the efficacy of relieving visual fatigue of the present invention.
Embodiment 4
Use embodiment 2 and the asthenopic granule of alleviation of embodiment 3 preparation or capsule treatment visual fatigue Disease.Selecting long-term eye, the fatigable adult of eyesight is as tested crowd.All meet above-mentioned condition and from It is willing to participate in and ensure that cooperation person all includes test in；To not meeting the experimenter including age criterion in, to health care food Product allergy sufferers, suffers from infectious eye disease person, the inside and outside eye disease patient such as nebula, keratoconus, suffers from There is fundus oculi disease or be associated with the diseases such as cardiovascular, the cerebrovascular, liver, kidney, hemopoietic system, take in a short time Article relevant with tested function, have influence on the judgement person to result, other relevant treatment eyesights of long-term taking Medicine or use other treatment method to fail terminator etc. the most not include data statistics in.Use between self and group two Plant control design, according to random, the requirement of double blinding, inclusive criteria will be met and ensure the voluntary of compatibility test Experimenter, according to symptom, eye test situation, consider the age simultaneously, the factor of sex is divided into test-meal group and Control group.Test-meal group takes granule sample or capsule according to RD, and control group takes placebo, even Continuous 45 days.Original eating habit, normal diet is not changed during test.
Inventor carries out statistical analysis to following functions index:
Symptom Observation: in detail inquiry visual fatigue situation, observes ophthalmodynia, eye is swollen, photophobia, blurred vision, eye The symptom such as dry and astringent, by mild symptoms multiple integral (severe 3 points, middle disease 2 points, mild 1 point) before and after test-meal Statistics integrated value, and (arbitrary symptom improves 1 point and above for improving) situation is improved with regard to its symptom, observe Symptom improvement rate.
Visuognosis persistence test.
Distant vision measures.
Symptom integral system before and after the medicine composition for relieving eyestrain test-meal of table 1. embodiment 2 and embodiment 3 preparation Meter
Group Before test-meal After test-meal
Control group 8.55±1.10 8.26±1.15
Embodiment 2 8.53±1.26 7.13±1.21*#
Embodiment 3 8.49±1.08 7.01±1.01*#
* compare with control group, P < 0.05,#Compare with self, P < 0.05.
Before and after the alleviation visual fatigue pharmaceutical composition test-meal of table 2. embodiment 2 preparation, symptom improves situation
Before and after the alleviation visual fatigue pharmaceutical composition test-meal of table 3. embodiment 3 preparation, symptom improves situation
Before and after the alleviation visual fatigue pharmaceutical composition test-meal of table 4. embodiment 2 and embodiment 3 preparation, function is observed and is compared
* compare with control group, P < 0.05.
The alleviation visual fatigue pharmaceutical composition impact on duration of photopic vision of table 4 embodiment 2 and embodiment 3 preparation
Group Before test-meal After test-meal Increase rate
Control group 0.54±0.06 0.54±0.06 0.02±0.01
Embodiment 2 groups 0.55±0.06 0.66±0.07*# 0.11±0.01
Embodiment 3 groups 0.52±0.06 0.64±0.12*# 0.12±0.06
* compare with control group, P < 0.05；#Compare with self, P < 0.05.
Before and after table 5. same dose order side 1 (Bilberry fruit P.E) test-meal, symptom improves situation
Before and after table 6. same dose order side 2 (wolfberry fruit extract) test-meal, symptom improves situation
Before and after table 7. same dose order side 3 (Flos Tagetis Erectae extract) test-meal, symptom improves situation
Table 8. same dose order side improves the contrast and experiment of situation with compound duration of photopic vision
Control group Compound 1 Compound 2 Folk prescription 1 Folk prescription 2 Folk prescription 3
Placebo Embodiment 2 Embodiment 3 Bilberry fruit P.E Wolfberry fruit extract Flos Tagetis Erectae extract
0.54±0.06 0.66±0.07* 0.64±0.12* 0.59±0.03* 0.58±0.06* 0.61±0.05*
* compare with control group, P < 0.05.
Wherein, Bilberry fruit P.E powder, Flos Tagetis Erectae extract and wolfberry fruit extract in embodiment 2 and embodiment 3 Total amount accounts for the 91.11% of pharmaceutical preparation gross mass, and folk prescription 1～3 is respectively respective extract 100%.Pass through table 8 it can be seen that in the case of each Ingredient Amount is less, the drug effect of composition is in duration of photopic vision improvement side The effect in face is substantially better than the folk prescription component that consumption is more.
Embodiment described above is only the preferred embodiment lifted by absolutely proving the present invention, the present invention's Protection domain is not limited to this.Equivalent that those skilled in the art are made on the basis of the present invention substitute or Conversion, all in protection scope of the present invention.

Claims (9)

1. a composition for relieving asthenopia, it is characterised in that described composition contains the cowberry of effective dose Or Bilberry fruit P.E；Matrimony vine or wolfberry fruit extract；And, lutein or Flos Tagetis Erectae extract.
Composition for relieving asthenopia the most according to claim 1, it is characterised in that described cowberry The Extraction solvent of extract, wolfberry fruit extract or Flos Tagetis Erectae extract is water, C1～C4Alcohol, acetone, chloroform, One or more in dichloromethane, ether, ethyl acetate and hexane.
Composition for relieving asthenopia the most according to claim 2, it is characterised in that described cowberry carries The preparation method taking thing is: take cowberry dry fruit, squeezes after cleaning, and pressed liquor uses stainless steel mesh mistake Filter, filtrate water dilutes and is uniformly dispersed, and obtains cranberry pressed liquor；By dynamic for cranberry pressed liquor Being adsorbed in the AB-8 macroreticular resin pre-processed, first with water elution, elution flow rate is 60L/h, discards washing De-liquid；Again with concentration expressed in percentage by volume 70% ethanol elution, elution flow rate is 30L/h, collects ethanol eluate, Obtain cowberry active component eluent；The cowberry active component eluent of gained is evaporated to relative density 1.05～1.20, then drying under reduced pressure, dried object is pulverized, is obtained Bilberry fruit P.E.
Composition for relieving asthenopia the most according to claim 2, it is characterised in that described matrimony vine carries The preparation method taking thing is: matrimony vine is extracted twice in the water of 85～95 DEG C, and each 2 hours, extract was adopted Filtering with stainless steel mesh, reduced pressure concentration after cooling, concentrate adds ethanol, adjusts ethanol volume basis dense Degree is 80%, obtains the ethanol precipitated liquid of matrimony vine, after precipitation drying under reduced pressure, pulverizes and make powder, obtain Chinese holly Qi extract.
Composition for relieving asthenopia the most according to claim 2, it is characterised in that described marigold The preparation method of extract is: marigold makes marigold particles, at fermentation tank through dehydration, drying after cleaning Middle fermentation, is placed in the n-hexane of 55～65 DEG C leaching 1.5h by the marigold particles after fermentation, filters, add Push back medicinal extract saponification 5～10h in the KOH solution of 66～70 DEG C after receipts n-hexane, filter, drying under reduced pressure, Obtain Flos Tagetis Erectae extract.
6. according to the arbitrary described composition for relieving asthenopia of Claims 1 to 5, it is characterised in that respectively become Demultiplexing amount is: cowberry or Bilberry fruit P.E 0.1～250 weight portion；Matrimony vine or wolfberry fruit extract 0.1～150 weight Part；Lutein or Flos Tagetis Erectae extract 0.1～200 weight portion.
Composition for relieving asthenopia the most according to claim 6, it is characterised in that each Ingredient Amount For: cowberry or Bilberry fruit P.E 120～220 weight portion；Matrimony vine or wolfberry fruit extract 80～90 weight portion；Leaf Flavine or Flos Tagetis Erectae extract 110～200 weight portion.
8. the arbitrary described composition for relieving asthenopia of claim 1～7 is used for alleviating asthenopic in preparation Medicine, health food for alleviating eye fatigue or alleviate the application in asthenopic beverage.
Application the most according to claim 8, when preparing Asthenopia-relievinghealthcare healthcare food, institute The addition stating composition accounts for the 0.01～15% of health food gross weight, and preparation is used for alleviating asthenopic beverage Time, every 100ml beverage contains described composition 0.1～30g.
CN201610341057.7A 2016-05-20 2016-05-20 Composition for relieving visual fatigue Pending CN105878573A (en)

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CN106701381A (en) * 2016-12-20 2017-05-24 广州聚澜健康产业研究院有限公司 Female healthcare wine capable of relieving eyestrain
CN107997048A (en) * 2017-11-29 2018-05-08 中国科学院兰州化学物理研究所 A kind of composition for having effects that to improve eyesight
CN108079127A (en) * 2017-12-31 2018-05-29 珠海大爱科技有限公司 A kind of eye strain of releiving, dry and astringent, acid is swollen, promotes the moxa of uncorrected visual acuity
CN108095112A (en) * 2017-12-18 2018-06-01 苏州诺衡生命科技有限公司 One kind contributes to health food for relieving visual fatigues of health food and preparation method
CN108260778A (en) * 2016-12-30 2018-07-10 西藏天麦力健康品有限公司 It is a kind of that there is protection eyesight, antifatigue health food and its processing method
CN108542970A (en) * 2018-03-08 2018-09-18 安徽九华华源药业有限公司 Alleviate the health products and preparation method thereof of asthenopia
CN109010375A (en) * 2018-09-11 2018-12-18 厦门阿欧客健康科技有限公司 A kind of collyrium
CN109770364A (en) * 2019-03-07 2019-05-21 通化禾韵现代农业股份有限公司 With composition, the preparation method and application for alleviating visual fatigue function
CN110384235A (en) * 2018-04-20 2019-10-29 浙江新维士生物科技有限公司 Improve food compositions, the oral preparation and preparation method thereof of visual fatigue
CN111248448A (en) * 2020-02-10 2020-06-09 云南中科本草科技有限公司 Composition for relieving eye fatigue, preparation method thereof and medicine or health food for relieving eye fatigue
CN112336761A (en) * 2020-12-04 2021-02-09 广州陈锦济生物科技有限公司 Anti-radiation eye moistening liquid and preparation method thereof
CN112586646A (en) * 2020-02-28 2021-04-02 河北康平健康产业有限责任公司 Solid beverage with eyesight protecting and asthenopia relieving functions and preparation method thereof
CN113273690A (en) * 2021-06-08 2021-08-20 烟台阿波罗生物药业科技有限公司 New resource food for improving asthenopia
CN113332362A (en) * 2020-03-02 2021-09-03 张腾龙 Application of pharmaceutical composition in preparing medicine for treating pseudomyopia

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CN103584101A (en) * 2013-11-20 2014-02-19 山西振东五和健康食品股份有限公司 Asthenopia-relieving healthcare food and preparation method thereof
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Publication number Priority date Publication date Assignee Title
CN106701381A (en) * 2016-12-20 2017-05-24 广州聚澜健康产业研究院有限公司 Female healthcare wine capable of relieving eyestrain
CN108260778A (en) * 2016-12-30 2018-07-10 西藏天麦力健康品有限公司 It is a kind of that there is protection eyesight, antifatigue health food and its processing method
CN107997048A (en) * 2017-11-29 2018-05-08 中国科学院兰州化学物理研究所 A kind of composition for having effects that to improve eyesight
CN107997048B (en) * 2017-11-29 2021-03-30 中国科学院兰州化学物理研究所 Composition with eyesight improving effect
CN108095112A (en) * 2017-12-18 2018-06-01 苏州诺衡生命科技有限公司 One kind contributes to health food for relieving visual fatigues of health food and preparation method
CN108079127A (en) * 2017-12-31 2018-05-29 珠海大爱科技有限公司 A kind of eye strain of releiving, dry and astringent, acid is swollen, promotes the moxa of uncorrected visual acuity
CN108542970A (en) * 2018-03-08 2018-09-18 安徽九华华源药业有限公司 Alleviate the health products and preparation method thereof of asthenopia
CN110384235A (en) * 2018-04-20 2019-10-29 浙江新维士生物科技有限公司 Improve food compositions, the oral preparation and preparation method thereof of visual fatigue
CN109010375A (en) * 2018-09-11 2018-12-18 厦门阿欧客健康科技有限公司 A kind of collyrium
CN109770364A (en) * 2019-03-07 2019-05-21 通化禾韵现代农业股份有限公司 With composition, the preparation method and application for alleviating visual fatigue function
CN111248448A (en) * 2020-02-10 2020-06-09 云南中科本草科技有限公司 Composition for relieving eye fatigue, preparation method thereof and medicine or health food for relieving eye fatigue
CN112586646A (en) * 2020-02-28 2021-04-02 河北康平健康产业有限责任公司 Solid beverage with eyesight protecting and asthenopia relieving functions and preparation method thereof
CN113332362A (en) * 2020-03-02 2021-09-03 张腾龙 Application of pharmaceutical composition in preparing medicine for treating pseudomyopia
CN112336761A (en) * 2020-12-04 2021-02-09 广州陈锦济生物科技有限公司 Anti-radiation eye moistening liquid and preparation method thereof
CN113273690A (en) * 2021-06-08 2021-08-20 烟台阿波罗生物药业科技有限公司 New resource food for improving asthenopia

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