CN112603971B - Cordyceps militaris and pericarpium citri reticulatae traditional Chinese medicine composition, preparation method and application thereof - Google Patents

Cordyceps militaris and pericarpium citri reticulatae traditional Chinese medicine composition, preparation method and application thereof Download PDF

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CN112603971B
CN112603971B CN202011642408.0A CN202011642408A CN112603971B CN 112603971 B CN112603971 B CN 112603971B CN 202011642408 A CN202011642408 A CN 202011642408A CN 112603971 B CN112603971 B CN 112603971B
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extract
traditional chinese
cordyceps militaris
chinese medicine
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CN112603971A (en
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江森
黄志敏
王冰
何风雷
雷冑熙
商雪莹
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Guangzhou Baiyunshan Chen Liji Pharmaceutical Factory Co ltd
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Abstract

The invention provides a cordyceps militaris and dried orange peel traditional Chinese medicine composition, a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following preparation raw materials: parched Coicis semen, poria, rhizoma Dioscoreae, fructus Lycii, cordyceps militaris, radix Puerariae, glycyrrhrizae radix, parched semen Fagopyri Esculenti, bulbus Lilii, ampelopsis Grossdentata and pericarpium Citri Tangerinae. The invention forms a specific traditional Chinese medicine formula by selecting the types of medicinal materials, particularly reasonably matching the selected medicinal materials. The traditional Chinese medicine formula has obvious drug effect, has the effects of promoting urination, clearing damp, tonifying spleen and kidney, does not damage healthy qi, can effectively reduce the high uric acid level in vivo, relieves the clinical symptoms of gout patients, has the effects of clearing damp, reducing swelling and the like, can effectively cover the bitter taste of medicinal materials, highlights the fragrance of the medicinal materials, and has good taste.

Description

Cordyceps militaris and pericarpium citri reticulatae traditional Chinese medicine composition, preparation method and application thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and relates to a cordyceps militaris and dried orange peel traditional Chinese medicine composition, a preparation method and application thereof.
Background
Hyperuricemia refers to the long-term continuous hyperuricemia of human blood uric acid and the formation of urate crystal deposition. The main causes of uric acid production are decreased urine due to intake of excessive high-purine foods (e.g., seafood, broth, animal viscera, beer, etc.), purine metabolic disorders in the human body, and renal excretion dysfunction. Hyperuricemia is related to the occurrence and development of diseases such as gout, metabolic syndrome and the like, and is closely related to kidney damage. With the rise of blood uric acid level, glomerular filtration rate is obviously reduced, and the risk of renal failure is obviously increased.
According to reports, western medicines including colchicine, allopurinol, benzbromarone, non-steroidal anti-inflammatory drugs, glucocorticoids, adrenocorticotropic hormone or steroids are mainly adopted for treating hyperuricemia and gout at present. However, all the clinical western medicines have certain risks of liver and kidney injury and allergy, and the toxic and side effects of the medicines limit the clinical use. Therefore, the selection of the medicinal and edible traditional Chinese medicinal materials with definite curative effect, no toxic or side effect and no drug resistance, the synergistic effect of the medicinal and edible traditional Chinese medicinal materials on clinical western medicines, and even the replacement of part of the western medicines with large toxic or side effect can generate huge social and economic benefits. For example, the cordyceps militaris composition for treating gout comprises the following raw material medicines in parts by mass: 20 to 40 parts of cordyceps militaris, 15 to 35 parts of burdock root, 12 to 20 parts of lily and 8 to 15 parts of tuckahoe. However, the composition has too single component, so that the effects of promoting urination, clearing damp, tonifying spleen and tonifying kidney are not obvious enough, and the composition is only suitable for patients with high uric acid with non-phlegm-dampness constitution and is less suitable for people. The product prepared by the traditional Chinese medicine formula keeps the taste and flavor of the traditional Chinese medicine, has poor eating experience, has poor efficacy if the taste and the flavor are improved, and is difficult to take into consideration, and particularly, the traditional Chinese medicine formula is prepared into modern beverages such as tea bags and the like.
Disclosure of Invention
Based on the above, the main purpose of the invention is to provide a traditional Chinese medicine composition, a preparation method and application thereof. The traditional Chinese medicine composition provided by the invention has reasonable compatibility of medicinal materials, and the compatibility of medicines not only has obvious drug effect, but also can effectively cover the bitter taste of the medicinal materials, highlight the fragrance of the medicinal materials and has good taste.
The purpose of the invention is realized by the following technical scheme:
a traditional Chinese medicine composition comprises the following preparation raw materials: parched Coicis semen, poria, rhizoma Dioscoreae, fructus Lycii, cordyceps militaris, radix Puerariae, glycyrrhrizae radix, parched semen Fagopyri Esculenti, bulbus Lilii, ampelopsis Grossdentata and pericarpium Citri Tangerinae.
In one embodiment, the traditional Chinese medicine composition comprises the following preparation raw materials in parts by weight: 70 to 100 parts of fried coix seed, 45 to 75 parts of tuckahoe, 40 to 75 parts of yam, 75 to 105 parts of medlar, 60 to 80 parts of cordyceps militaris, 50 to 70 parts of kudzuvine root, 6 to 18 parts of liquorice, 75 to 105 parts of fried buckwheat, 45 to 75 parts of lily, 5 to 15 parts of ampelopsis grossedentata and 10 to 20 parts of tangerine peel.
In one embodiment, the traditional Chinese medicine composition comprises the following preparation raw materials in parts by weight: 85 to 100 parts of fried coix seed, 60 to 75 parts of tuckahoe, 55 to 75 parts of yam, 95 to 105 parts of medlar, 65 to 80 parts of cordyceps militaris, 60 to 70 parts of kudzuvine root, 10 to 18 parts of liquorice, 90 to 105 parts of fried buckwheat, 65 to 75 parts of lily, 10 to 15 parts of ampelopsis grossedentata and 13 to 18 parts of dried orange peel.
In one embodiment, the traditional Chinese medicine composition comprises the following preparation raw materials in parts by weight: 85 to 95 parts of fried coix seed, 60 to 65 parts of tuckahoe, 58 to 63 parts of yam, 98 to 102 parts of medlar, 65 to 70 parts of cordyceps militaris, 60 to 64 parts of kudzuvine root, 13 to 16 parts of liquorice, 90 to 100 parts of fried buckwheat, 65 to 70 parts of lily, 10 to 14 parts of ampelopsis grossedentata and 13 to 16 parts of tangerine peel.
In one embodiment, the Chinese medicinal composition is a tea bag.
The embodiment of the invention provides a preparation method of the traditional Chinese medicine composition, which comprises the steps of taking the preparation raw materials and preparing the traditional Chinese medicine composition.
In one embodiment, the preparation method comprises the following steps:
the preparation method comprises the steps of preparing the extract A1, the extract A2 and powder respectively, mixing the extract A1, the extract A2 and the powder and drying the obtained mixture; wherein:
the step of preparing extract A1 comprises: taking the fried coix seeds, the poria cocos and the Chinese yams, adding water for extraction, collecting water extract, concentrating the water extract to obtain water extract concentrated solution, precipitating the water extract concentrated solution by using an ethanol solution, collecting supernate, and concentrating the supernate;
the step of preparing extract A2 comprises: adding water into the wolfberry fruit, the cordyceps militaris, the radix puerariae and the liquorice for extraction, collecting a water extract, and concentrating the water extract;
the method for preparing the powder comprises the following steps: pulverizing the parched semen Fagopyri Esculenti, bulbus Lilii, ampelopsis grossedentata and pericarpium Citri Tangerinae.
In one embodiment, the step of preparing extract A1 comprises: taking the fried coix seeds, the poria cocos and the Chinese yams, adding 8-10 times of water to extract for 1-3 times, each time for 0.5-1.5 h, collecting water extract, concentrating the water extract at 70-80 ℃ to obtain water extract concentrated solution with the density of 1.02-1.08, precipitating the water extract concentrated solution with 0.8-1 time of ethanol solution with the volume concentration of 90-98%, collecting supernatant, and concentrating the supernatant.
In one embodiment, the step of preparing extract A2 comprises: adding 8-10 times of water into the medlar, the cordyceps militaris, the radix puerariae and the liquorice, extracting for 1-3 times, each time for 0.5-1.5 h, collecting water extract, and concentrating the water extract at 70-80 ℃.
In one embodiment, the temperature used for drying is 70 ℃ to 80 ℃.
In one embodiment, the size of the powder is controlled to be 10 meshes-12 meshes.
In one embodiment, the extraction is performed by soaking.
The application of the traditional Chinese medicine composition in preparing products with the effects of strengthening spleen, tonifying kidney and/or reducing uric acid.
The invention has the following beneficial effects:
the invention forms a specific traditional Chinese medicine formula by selecting the types of medicinal materials, particularly reasonably matching the selected medicinal materials. The traditional Chinese medicine formula not only has obvious drug effect, for example, has the functions of promoting urination, clearing damp, tonifying spleen and kidney, but also does not damage healthy qi, can effectively reduce the high uric acid level in vivo, relieves the clinical symptoms of gout patients, has the functions of clearing damp, reducing swelling and the like, can effectively cover the bitter taste of medicinal materials, highlights the fragrance of the medicinal materials, and has good taste.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following more detailed description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
In order to make the objects, processes and advantages of the present invention more apparent, the present invention will be further described in detail with reference to the following examples. It should be noted that the following description is only an illustration of the technical solutions claimed in the present invention, and it should be understood that these technical solutions are not intended to limit the present invention.
The embodiment of the invention provides a traditional Chinese medicine composition which comprises the following preparation raw materials: parched Coicis semen, poria, rhizoma Dioscoreae, fructus Lycii, cordyceps militaris, radix Puerariae, glycyrrhrizae radix, parched semen Fagopyri Esculenti, bulbus Lilii, ampelopsis Grossdentata and pericarpium Citri Tangerinae.
The medicinal materials selected by the embodiment of the invention have the functions of promoting urination, clearing damp, reducing uric acid, invigorating spleen, tonifying kidney and the like, and specifically:
cordyceps militaris (L.) LinkCordyceps militaris(l.ex fr.) Link): belongs to the genus Cordyceps of the family of Maillariaceae, also known as Cordyceps militaris, cordyceps militaris. Cordyceps militaris contains various physiologically active substances such as Cordyceps polysaccharide, cordycepin, cordycepic acid, protein, amino acid, superoxide dismutase, etc. Has uric acid reducing, antitumor, antiviral, antioxidant, liver function improving, immunity regulating, sexual function protecting, and radioprotective effects.
Coix seed: sweet, bland and cool. It enters spleen, stomach and lung meridians. Induce diuresis, penetrate dampness, invigorate spleen, stop diarrhea, remove toxicity and dissipate nodulation. Can be used for treating edema, loempe, dysuresia, spleen deficiency, diarrhea, damp arthralgia, spasm, pulmonary abscess, and intestinal abscess; cancer and swelling.
Tuckahoe, poria cocos: sweet, bland and mild in nature. It enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Chinese yam: sweet and neutral in nature. It enters spleen, lung and kidney meridians. Strengthen the spleen and nourish the stomach, promote the production of body fluid and benefit the lung, tonify the kidney and arrest seminal emission. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, cough due to lung deficiency, spermatorrhea, leukorrhagia, frequent micturition, and diabetes. Can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and leukorrhagia.
Wolfberry fruit: mild in nature and slightly sweet in taste. Improving sexual desire, arresting spontaneous emission, replenishing essence, nourishing liver, improving eyesight, nourishing brain, tranquilizing mind, reducing fat, cleaning blood, and eliminating urine sugar.
Kudzu root: it is sweet, pungent and cool. It enters spleen, stomach and lung meridians. Expelling pathogenic factors from muscles and skin, relieving fever, promoting salivation, quenching thirst, promoting eruption, invigorating yang, relieving diarrhea, dredging meridian passage, and relieving alcoholism. Can be used for treating fever, headache, stiffness and pain of neck and back, thirst, diabetes, measles without adequate eruption, dysentery due to heat evil, diarrhea, vertigo, headache, apoplexy, hemiplegia, thoracic obstruction, cardiodynia, and alcoholic injury.
Licorice root: it is sweet and neutral. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of the spleen and the stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough and excessive phlegm, carbuncle and swelling and sore toxicity, and relieving toxicity and intensity of the medicament.
Buckwheat: it is sweet and cold in nature. Stimulate the appetite, widen the intestines, remove food retention, stop diarrhea. Can be used for treating gastrointestinal stagnation and chronic diarrhea. It is indicated for burns due to hot liquid or fire.
Dried orange peel: bitter and pungent in flavor and warm in nature. It enters lung and spleen meridians. To regulate qi, strengthen spleen, dry dampness and resolve phlegm. Can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm.
Vine tea: bitter, slightly astringent and cool. Clearing away heat and promoting diuresis; calming the liver and reducing blood pressure; promoting blood circulation and removing obstruction in channels. Dysentery, diarrhea, stranguria with urine; hypertension; dizziness, distention of the eyes and traumatic injury.
Lily: it is sweet and cold in nature. It enters heart and lung meridians. Nourish yin and moisten lung, clear heart and induce tranquilization. Can be used for treating yin deficiency and dry cough, fatigue cough and hemoptysis, dysphoria, palpitation, insomnia, dreaminess, absentmindedness.
The traditional Chinese medicine composition provided by the embodiment of the invention is completely from medicine-food homologous and new resource food, is green and healthy, and has no any additive or toxic or side effect. The traditional Chinese medicine composition has the effects of promoting urination, removing dampness, strengthening spleen, tonifying kidney and promoting uric acid excretion, can neutralize acidic substances in blood, is discharged in the form of urine, effectively discharges urate crystals in kidney, enhances the urine filtering capability of kidney, and effectively avoids side effects and drug dependence brought by taking drugs for treating hyperuricemia.
In one example, the traditional Chinese medicine composition comprises the following preparation raw materials in parts by weight: 70 to 100 parts of fried coix seed, 45 to 75 parts of tuckahoe, 40 to 75 parts of yam, 75 to 105 parts of medlar, 60 to 80 parts of cordyceps militaris, 50 to 70 parts of kudzuvine root, 6 to 18 parts of liquorice, 75 to 105 parts of fried buckwheat, 45 to 75 parts of lily, 5 to 15 parts of ampelopsis grossedentata and 10 to 20 parts of tangerine peel.
The traditional Chinese medicine composition disclosed by the embodiment of the invention has the effects of inducing diuresis, clearing damp, tonifying spleen and tonifying kidney through compatibility of the components and processing of the raw materials, does not damage vital qi, can effectively reduce the high uric acid level in vivo, relieves the clinical symptoms of gout patients, has the effects of clearing damp, reducing swelling and the like, and has a wide application value. In the traditional Chinese medicine composition provided by the embodiment of the invention, the raw materials of the coix seed (fried), the poria cocos, the Chinese yam, the Chinese wolfberry, the cordyceps militaris, the kudzuvine root, the liquorice root, the buckwheat (fried), the lily, the ampelopsis grossedentata and the like have obvious effects of inducing diuresis, eliminating dampness, tonifying spleen, tonifying kidney and reducing uric acid, and the effects of strengthening spleen, eliminating dampness and reducing uric acid can be obviously enhanced by adding the Xinhui tangerine peel.
The traditional Chinese medicine composition disclosed by the embodiment of the invention has high crude drug content, can completely cover up the bitter taste of medicinal materials through reasonable compatibility without adding any flavoring agent, has good mouthfeel, also obviously highlights the unique aroma of cordyceps militaris and Xinhui dried orange peel, and can be used for preparing a new-generation green functional food.
In one example, the traditional Chinese medicine composition comprises the following preparation raw materials in parts by weight: 85 to 100 parts of fried coix seed, 60 to 75 parts of tuckahoe, 55 to 75 parts of yam, 95 to 105 parts of medlar, 65 to 80 parts of cordyceps militaris, 60 to 70 parts of kudzuvine root, 10 to 18 parts of liquorice, 90 to 105 parts of fried buckwheat, 65 to 75 parts of lily, 10 to 15 parts of ampelopsis grossedentata and 13 to 18 parts of dried orange peel.
In one example, the traditional Chinese medicine composition comprises the following preparation raw materials in parts by weight: 85 to 95 parts of fried coix seed, 60 to 65 parts of tuckahoe, 58 to 63 parts of yam, 98 to 102 parts of medlar, 65 to 70 parts of cordyceps militaris, 60 to 64 parts of kudzuvine root, 13 to 16 parts of liquorice, 90 to 100 parts of fried buckwheat, 65 to 70 parts of lily, 10 to 14 parts of ampelopsis grossedentata and 13 to 16 parts of tangerine peel.
In one example, the Chinese medicinal composition is a tea bag.
The embodiment of the invention provides a preparation method of the traditional Chinese medicine composition, and the preparation method comprises the steps of taking the preparation raw materials and preparing the traditional Chinese medicine composition.
In one example, the preparation method comprises:
the preparation method comprises the steps of preparing the extract A1, the extract A2 and powder respectively and mixing the extract A1, the extract A2 and the powder and drying the obtained mixture; wherein:
the step of preparing extract A1 comprises: extracting the fried coix seeds, the poria cocos and the Chinese yams with water, collecting water extract, concentrating the water extract to obtain water extract concentrated solution, precipitating the water extract concentrated solution with ethanol solution, collecting supernatant, and concentrating the supernatant;
the step of preparing extract A2 comprises: adding water into the medlar, the cordyceps militaris, the radix puerariae and the liquorice for extraction, collecting water extract, and concentrating the water extract;
the powder preparation method comprises the following steps: pulverizing the parched semen Fagopyri Esculenti, bulbus Lilii, ampelopsis grossedentata and pericarpium Citri Tangerinae.
In one example, the step of preparing extract A1 comprises: taking the fried coix seeds, the poria cocos and the Chinese yams, adding 8-10 times of water to extract for 1-3 times, each time for 0.5-1.5 h, collecting water extract, concentrating the water extract at 70-80 ℃ to obtain water extract concentrated solution with the density of 1.02-1.08, precipitating the water extract concentrated solution with 0.8-1 time of ethanol solution with the volume concentration of 90-98%, collecting supernatant, and concentrating the supernatant.
In one example, the step of preparing extract A2 comprises: adding 8-10 times of water into the medlar, the cordyceps militaris, the radix puerariae and the liquorice, extracting for 1-3 times, each time for 0.5-1.5 h, collecting water extract, and concentrating the water extract at 70-80 ℃.
In one example, the temperature used for drying is 70 ℃ to 80 ℃.
In one example, the size of the powder is controlled to be 10-12 meshes.
In one example, the extraction is performed by soaking.
The application of the traditional Chinese medicine composition in preparing products with the effects of strengthening spleen, tonifying kidney and/or reducing uric acid.
It can be understood that the formula according to the embodiment of the present invention can be prepared into any dosage form product according to the needs, preferably, the product can be prepared into tea bags, and compared with granules, tablets and the like, the tea bags have the advantages of good taste, no bitter taste of traditional Chinese medicinal materials, strong fragrance, no additives such as essence, sweetener and the like, convenience for carrying and drinking, high crude drug content, rapid dissolution, good absorption and utilization, and the like. For patients with high uric acid and gout, the tea bag provided by the embodiment of the invention can replace high fructose beverages in daily life, does not damage healthy qi and generate dependence after long-term drinking, and can effectively reduce the high uric acid level in vivo and relieve the clinical symptoms of the patients with gout.
The preparation process of the teabag provided by the embodiment of the invention has the advantages of high stability, controllable quality, strong operability of each process, contribution to industrial production, and capability of keeping the active ingredients of the raw materials to the maximum extent and fully extracting and dissolving the active substances of each component according to different properties of the raw materials by different treatment modes, including processes of processing, crushing, water extraction and alcohol precipitation and the like, so that the teabag has remarkable effects of promoting urination, clearing damp, reducing uric acid, strengthening spleen and tonifying kidney.
The embodiment of the invention is originally created by reasonable formula, raw material processing and process optimization, can be prepared into the teabag product with the effects of promoting urination, eliminating dampness, reducing uric acid, invigorating spleen and tonifying kidney, has high crude drug content, definite curative effect, no harm to healthy qi, long-term taking, wide applicable population, convenient use, good taste, obvious fragrance of the tangerine peel and the cordyceps militaris and no bitter taste.
The raw materials of the examples of the present invention are commercially available.
Embodiment 1, cordyceps militaris and dried orange peel tea bag with effects of tonifying spleen, tonifying kidney and reducing uric acid and preparation method
The embodiment provides a cordyceps militaris and dried orange peel teabag with effects of invigorating spleen, tonifying kidney and reducing uric acid, which is prepared from the following raw materials in parts by weight:
90 parts of coix seeds (fried), 60 parts of poria cocos, 60 parts of Chinese yam, 100 parts of wolfberry fruits, 65 parts of cordyceps militaris, 60 parts of kudzu roots, 15 parts of dried orange peels, 90 parts of buckwheat (fried), 65 parts of lilies, 15 parts of liquorice and 10 parts of vine tea; wherein the pericarpium Citri Tangerinae is Xinhui pericarpium Citri Tangerinae.
The embodiment also provides a preparation method of the cordyceps militaris and dried orange peel teabag with the effects of invigorating spleen, tonifying kidney and reducing uric acid, and the preparation method comprises the following steps of preparing the cordyceps militaris and dried orange peel teabag: (1) Extracting Coicis semen (parched), poria, and rhizoma Dioscoreae with water, precipitating with ethanol, and collecting extract; (2) Water extract of fructus Lycii, cordyceps militaris, radix Puerariae, and radix Glycyrrhizae; (3) Semen Fagopyri Esculenti (parched), bulbus Lilii, pericarpium Citri Tangerinae, and Ampelopsis grossedentata (Ampelopsis grossedentata) pulverized parts. Specifically, the method comprises the following steps:
(1) The preparation method of the extract part of the water extraction and alcohol precipitation liquid of the coix seed (fried), the tuckahoe and the Chinese yam comprises the following steps:
soaking Coicis semen (parched), poria and rhizoma Dioscoreae in 10 times of water for 1 hr, extracting twice, filtering to obtain two water extractive solutions, and mixing;
concentrating the combined water extract until the density reaches 1.04 (the temperature is 70-80 ℃) to obtain water extract concentrated solution;
adding 95% ethanol with volume equivalent to 0.8 times of the water extract, precipitating with ethanol, standing overnight, collecting supernatant, and concentrating to obtain water extract and ethanol precipitate extract A1.
(2) The preparation method of the water extract part of the medlar, the cordyceps militaris, the kudzu root and the liquorice comprises the following steps:
soaking the four raw materials of the medlar, the cordyceps militaris, the radix puerariae and the liquorice in 10 times of water for 1 hour, extracting twice, filtering extracting solutions, combining the water extracting solutions, and concentrating (the concentration is carried out until the density reaches 1.04, and the concentration temperature is 70-80 ℃) to obtain an aqueous extract A2.
(3) The preparation method of the crushed parts of buckwheat (fried), lily, ampelopsis grossedentata and dried orange peel comprises the following steps:
the four raw materials of the buckwheat (fried), the lily, the dried orange peel and the vine tea are weighed, crushed and screened by a screen with 10 meshes to 12 meshes to prepare medicinal coarse powder.
The steps of preparing the cordyceps militaris and dried orange peel teabag from the three parts comprise:
1) Uniformly mixing the water extraction and alcohol precipitation liquid extract A1, the water extraction and alcohol precipitation liquid extract A2 and the crude powder of the medicinal materials, and drying the mixture in an oven at the temperature of 70-80 ℃;
2) Pulverizing the above dried extract mixture into coarse powder;
3) And (3) filling the qualified coarse powder into filter paper bags by using a full-automatic bag tea racking machine, and then filling into composite film bags with good sealing and moisture-proof performances, wherein the filling amount of each bag is 3g, so that the cordyceps militaris and dried orange peel bag tea can be obtained.
Embodiment 2, cordyceps militaris and dried orange peel tea bag with effects of tonifying spleen, tonifying kidney and reducing uric acid and preparation method
The embodiment provides a cordyceps militaris and dried orange peel teabag with effects of invigorating spleen, tonifying kidney and reducing uric acid, which comprises the following preparation raw materials in parts by weight:
100 parts of coix seeds (fried), 75 parts of poria cocos, 75 parts of Chinese yam, 105 parts of wolfberry fruits, 80 parts of cordyceps militaris, 70 parts of kudzu roots, 18 parts of liquorice, 105 parts of buckwheat (fried), 75 parts of lily, 18 parts of dried orange peels and 15 parts of ampelopsis grossedentata;
wherein the pericarpium Citri Tangerinae is Xinhui pericarpium Citri Tangerinae.
The embodiment of the invention also provides a preparation method of the cordyceps militaris and dried orange peel teabag with the effects of invigorating spleen, tonifying kidney and reducing uric acid, and the preparation method comprises the following steps of preparing the cordyceps militaris and dried orange peel teabag: (1) Extracting Coicis semen (parched), poria, and rhizoma Dioscoreae with water, precipitating with ethanol, and collecting extract; (2) Water extract of fructus Lycii, cordyceps militaris, radix Puerariae, and radix Glycyrrhizae; (3) Semen Fagopyri Esculenti (parched), bulbus Lilii, pericarpium Citri Tangerinae, and Ampelopsis grossedentata (Ampelopsis grossedentata) pulverized parts. Specifically, the method comprises the following steps:
(1) The preparation method of the extract part of the water extraction and alcohol precipitation liquid of the coix seed (fried), the tuckahoe and the Chinese yam comprises the following steps:
soaking Coicis semen (parched), poria and rhizoma Dioscoreae in 8 times of water for 1 hr, extracting twice, filtering to obtain two extractive solutions, and mixing;
concentrating the combined water extract until the density reaches 1.05 (the temperature is 70-80 ℃) to obtain water extract concentrated solution;
adding 95% ethanol with volume equivalent to 0.9 times of the water extraction concentrate, precipitating with ethanol, standing overnight, collecting supernatant, and concentrating to obtain water extraction and ethanol precipitation extract A1.
(2) The preparation method of the water extract part of the medlar, the cordyceps militaris, the kudzu root and the liquorice comprises the following steps:
soaking the four raw materials of the medlar, the cordyceps militaris, the radix puerariae and the liquorice in 8 times of water for 1 hour, extracting twice, filtering extracting solutions, combining the water extracting solutions, and concentrating (concentrating until the density reaches 1.05 and the temperature is 70-80 ℃) to obtain an aqueous extract A2.
(3) The preparation method of the crushed parts of the buckwheat (fried), the lily, the ampelopsis grossedentata and the dried orange peel comprises the following steps:
weighing four raw materials of buckwheat (fried), lily, dried orange peel and vine tea, crushing, sieving by a sieve of 10 meshes to 12 meshes, and preparing into mixed coarse powder.
The steps of preparing the cordyceps militaris and dried orange peel teabag from the three parts comprise:
1) Uniformly mixing the water extraction and alcohol precipitation liquid extract A1, the water extraction and alcohol precipitation liquid extract A2 and crude medicinal material powder, and drying in an oven at the temperature of 70-80 ℃;
2) Pulverizing the dried extract mixture into coarse powder;
3) And (3) filling the qualified coarse powder into filter paper bags by using a full-automatic bag tea racking machine, and then filling into composite film bags with good sealing and moisture-proof performances, wherein the filling amount of each bag is 3g, so that the cordyceps militaris and dried orange peel tea bags can be obtained.
Embodiment 3, cordyceps militaris and dried orange peel tea bag with effects of tonifying spleen, tonifying kidney and reducing uric acid and preparation method
The embodiment provides a cordyceps militaris and dried orange peel teabag with effects of invigorating spleen, tonifying kidney and reducing uric acid, which is prepared from the following raw materials in parts by weight:
85 parts of coix seeds (fried), 60 parts of poria cocos, 55 parts of Chinese yam, 95 parts of wolfberry fruits, 70 parts of cordyceps militaris, 65 parts of kudzu roots, 10 parts of liquorice, 100 parts of buckwheat (fried), 65 parts of lily, 13 parts of dried orange peels and 13 parts of vine tea;
wherein the pericarpium Citri Tangerinae is Xinhui pericarpium Citri Tangerinae.
The embodiment of the invention also provides a preparation method of the cordyceps militaris and dried orange peel teabag with the effects of invigorating spleen, tonifying kidney and reducing uric acid, and the preparation method comprises the following steps of preparing the cordyceps militaris and dried orange peel teabag: (1) Extracting Coicis semen (parched), poria, and rhizoma Dioscoreae with water, precipitating with ethanol, and collecting extract; (2) Water extract of fructus Lycii, cordyceps militaris, radix Puerariae, and radix Glycyrrhizae; (3) Pulverized part of semen Fagopyri Esculenti (parched), bulbus Lilii, pericarpium Citri Tangerinae, and Ampelopsis grossedentata. Specifically, the method comprises the following steps:
(1) The preparation method of the extract part of the water extraction and alcohol precipitation liquid of the coix seed (fried), the tuckahoe and the Chinese yam comprises the following steps:
soaking Coicis semen (parched), poria and rhizoma Dioscoreae in 9 times of water for 1 hr, extracting twice, filtering to obtain two water extractive solutions, and mixing;
concentrating the combined water extract until the density reaches 1.07 (the temperature is 70-80 ℃);
adding 95% ethanol with volume 1 time of that of the water extract, precipitating with ethanol, standing overnight, collecting supernatant, and concentrating to obtain water extract and ethanol precipitate extract A1.
(2) The preparation method of the water extract part of the medlar, the cordyceps militaris, the kudzuvine root and the liquorice comprises the following steps:
soaking the four raw materials of the medlar, the cordyceps militaris, the radix puerariae and the liquorice in 9 times of water for 1 hour, extracting for two times, filtering an extracting solution, combining the water extracting solutions, and concentrating (the density reaches 1.07, the temperature is 70-80 ℃) to obtain a water extracting solution extract A2.
(3) The preparation method of the crushed parts of the buckwheat (fried), the lily, the ampelopsis grossedentata and the dried orange peel comprises the following steps:
the four raw materials of buckwheat (fried), lily, dried orange peel and vine tea are weighed, crushed and screened by a screen of 10 meshes to 12 meshes to prepare mixed coarse powder.
The steps of preparing the cordyceps militaris and dried orange peel teabag by the three parts comprise:
1) Uniformly mixing the water extraction and alcohol precipitation liquid extract A1, the water extraction and alcohol precipitation liquid extract A2 and the crude powder of the medicinal materials, and drying the mixture in an oven at the temperature of 70-80 ℃;
2) Pulverizing the dried extract mixture into coarse powder;
3) And (3) filling the qualified coarse powder into filter paper bags by using a full-automatic bag tea racking machine, and then filling into composite film bags with good sealing and moisture-proof performances, wherein the filling amount of each bag is 3g, so that the cordyceps militaris and dried orange peel tea bags can be obtained.
Comparative example 1, cordyceps militaris and dried orange peel teabag with effects of tonifying spleen, tonifying kidney and reducing uric acid and preparation method
This comparative example is that of example 1, the main differences with respect to example 1 including: the comparative example adopts the water extraction and alcohol precipitation extract A1' of the coix seed (fried), the tuckahoe and the yam instead of the water extraction and alcohol precipitation extract A1 of the coix seed (fried), the tuckahoe and the yam. The treatments of the coix seed (fried), the tuckahoe and the yam in the comparative example are as follows:
soaking Coicis semen (parched), poria and rhizoma Dioscoreae for 1h, adding 10 times of water, extracting twice, filtering the extractive solutions, mixing water extractive solutions, and concentrating to obtain water extractive solution extract A1'.
The rest of the procedure was the same as in example 1.
Comparative example 2, cordyceps militaris and dried orange peel teabag with effects of tonifying spleen, tonifying kidney and reducing uric acid and preparation method
This comparative example is a comparative example to example 1, the main differences with respect to example 1 including: the comparative example adopts the water extraction and alcohol precipitation extract A1' of the coix seed (fried), the tuckahoe and the yam instead of the water extraction and alcohol precipitation extract A1 of the coix seed (fried), the tuckahoe and the yam. The treatments of semen coicis (parched), poria cocos and Chinese yam in this comparative example are as follows:
soaking Coicis semen (parched), poria and rhizoma Dioscoreae in 10 times of water for 1 hr, extracting twice, filtering to obtain two water extractive solutions, and mixing;
concentrating the combined water extract to a certain volume, centrifuging the obtained water extract by a centrifuge at a high speed of 4500 r/min for 20min, and concentrating the centrifuged supernatant to obtain water extract A1'.
The rest of the procedure was the same as in example 1.
Comparative example 3, cordyceps militaris and dried orange peel teabag with effects of tonifying spleen, tonifying kidney and reducing uric acid and preparation method
The comparative example is the comparative example of example 1, and the main differences relative to example 1 include differences of 'water extract A2' and 'crude drug powder', specifically as follows:
soaking fructus Lycii, radix Puerariae and Glycyrrhrizae radix in 10 times of water for 1 hr, extracting twice, filtering the extractive solutions, mixing the water extractive solutions, and concentrating to obtain water extractive solution extract A2';
weighing five raw materials of cordyceps militaris, buckwheat (fried), lily, ampelopsis grossedentata and dried orange peel, crushing, sieving by a 10-mesh sieve, and preparing into medicinal coarse powder'.
The rest of the procedure was the same as in example 1.
Experimental example 1, water extraction of bagged tea raw materials including semen Coicis (parched), poria and rhizoma Dioscoreae
The tea bag contains more polysaccharides and contains higher starch, so that the properties and taste of the tea bag are affected by directly brewing the raw materials after crushing, the preparation process of the tea bag is optimized, and the optimal process conditions for extracting the raw materials are determined by investigating the factors such as the extract content of tea water, the continuous brewing times, the sensory evaluation of the tea water and the like in order to furthest retain the active substances of the raw materials.
(1) The method for measuring the content of the water extract comprises the following steps:
with partial modification in reference to GB/T8305, 3g of sample was weighed into a 500mL conical flask, 300mL of boiling water was added, and the flask was placed in a boiling water bath for extraction for 45min, with shaking on average every 10 min. And (3) immediately filtering under reduced pressure after leaching, washing the raw material slag for a plurality of times by using 100 ml of boiling water, filtering washing liquid, collecting the raw material slag, transferring the raw material slag and filter paper with known mass into a drying dish, putting the raw material slag and a dish cover into a constant-temperature drying oven at 120 +/-2 ℃, drying for 1h, covering the drying oven, taking out the raw material slag, cooling for 1h, drying for 1h, immediately transferring the raw material slag into a dryer, cooling to room temperature, and weighing the weight of the drying dish.
Calculating the water extract content of the soluble solid of the raw material by the following formula:
water extract content (%) = (1-m) 1 / m 0 ×ω）×100%
In the formula, m 0 Is the sample mass (g), m 1 The mass (g) of the dried raw material slag, and omega is the dry matter content (%) of the sample.
TABLE 1 evaluation of different extraction process properties and sensory evaluation of bagged materials semen coicis, poria cocos and Chinese yam
Figure 952404DEST_PATH_IMAGE001
As can be seen from the above table, the extraction processes of the coix seed (fried), the tuckahoe and the yam in the tea bag raw materials are different, and the content of the water extract obtained by the final product is greatly different from that obtained by continuous brewing and sensory evaluation. The content of the water extract in example 1 is 2 times higher than that in comparative example 1, the content of the water extract in example 1 is 41.1% higher than that in comparative example 2, and the factors such as color, aroma and taste of tea water are different, so that the fact that the content of the tea bag is not completely brewed can be judged, and the reason is that the starch content in coix seeds (fried), poria cocos and Chinese yams is high, the process in comparative example 1 is only water extraction, a large amount of macromolecular substances such as starch are extracted, the extract is dried and made into the tea bag, and after the starch is gelatinized during brewing, pores of the filter paper bag can be blocked, so that the dissolution of effective components is influenced, and the longer the brewing time is, the more the filter paper bag is expanded. The process of comparative example 2 was water extraction and high speed centrifugation of the extract. Compared with direct water extraction, a part of starch can be removed after centrifugation, but due to the fact that the starch content is high, macromolecular substances such as clean starch cannot be completely removed although a certain effect is achieved, and the content cannot be completely brewed out. Through the comparison of the three test processes, the tea bag prepared by the water extraction and alcohol precipitation process of the coix seed (fried), the tuckahoe and the Chinese yam is determined to have the highest extract content and the best tea water quality.
Experimental example 2 experiment investigation of tea bag raw material cordyceps militaris extraction process
The cordyceps militaris belongs to cordyceps, is widely distributed and is recognized and accepted by various national scholars in the world, contains various chemical components, has strong health-care efficacy, has the effects of resisting tumors, regulating immunity, inhibiting bacteria, resisting oxidation and the like, has a prominent function of reducing uric acid, and has great significance for researching the extraction process of the cordyceps militaris on the product. In the test, according to the determination method of cordycepin and adenosine in the NY/T2116-2012 cordyceps sinensis product, content detection is carried out on active substances such as cordyceps militaris adenosine, cordycepin, total flavonoids and the like on the contents of the products in example 1 and comparative example 3 by using HPLC, and the results are shown in the following table:
TABLE 2 content of active substances of Cordyceps militaris in teabag
Figure 135124DEST_PATH_IMAGE002
As can be seen from the above table, the content of adenosine, cordycepin, total flavonoids and the like in the tea bag content is determined by HPLC experiments, the content in the example 1 is obviously higher than that in the comparative example 3, which shows that the effective ingredients obtained by the water extraction process of cordyceps militaris are obviously higher than that obtained by the crushing process. The experiment proves that the cordyceps militaris adopts a water extraction process, so that the leaching rate of the effective components is high, and the effect of reducing uric acid is better.
Experimental example 3 animal experiment for reducing uric acid by cordyceps militaris and dried orange peel teabag
60 male SPF Kunming mice (20 + -2 g) were taken, acclimatized for one week, and then randomly divided into 6 groups using a random number method: the test results were respectively a model control group, an example 1 group, an example 2 group, an example 3 group, an allopurinol group (positive control group), and a blank group. Except for the blank group, the hyperuricemia model of the mouse is established by the intragastric administration mode once a day for the other groups, and the medicine is as follows: potassium Oxazinate and physiological saline was administered to the blank group. On day 6, 0.5h after the administration of oteracil potassium, the corresponding therapeutic drugs were administered to the example 1 group, the example 2 group, the example 3 group, and the allopurinol group, respectively, and the same volume of physiological saline was gavaged for 7 consecutive days in the hyperuricemia model group and the blank group. After the intragastric administration for 1 hour on day 7, the anesthetized mice pick eyeballs and take blood, the centrifuger centrifuges the blood for 10min at the rotating speed of 4000r/min to obtain serum, and the concentration of uric acid in the serum is detected, and the results are shown in the following table:
TABLE 3 uric acid reducing effect of bagged cordyceps militaris (n = 10)
Figure 446019DEST_PATH_IMAGE003
In comparison to the blank set, the data was, △ p<0.05， △△ p<0.01; p compared to model control group<0.05，**p<0.01
The results in the table show that the serum uric acid concentration of the model control group is higher than that of the blank group, and significant differences exist, which indicates that the method for establishing the mouse hyperuricemia model by inducing the potassium oxonate in the test has high feasibility; the concentration level of the allopurinol positive control group serum uric acid is obviously lower than that of the model group, so that the positive control drug has the effect of resisting hyperuricemia, and the hyperuricemia model conforms to the logic and the integrity. Compared with a model group, the serum uric acid concentration water in the embodiments 1 to 3 of the invention is obviously reduced, and the difference between each group is small, which shows that the bagged tea can effectively reduce the uric acid concentration in an experimental mouse, can restore the uric acid level of the experimental mouse to be close to a normal level, has stability in the uric acid reducing degree, and further shows that the bagged tea of cordyceps militaris and dried orange peel has the function of reducing the uric acid.
In conclusion, the cordyceps militaris and dried orange peel teabags provided by the embodiment of the invention are prepared from the traditional Chinese medicinal materials which are proved to be safe and effective after long-term use and can be used as common food and are homologous to each other as well as functional new resource food, the cold and cool raw materials with larger usage amount in the formula are specially processed according to the characteristics, the channels and the efficacy of the medicinal materials, and the raw materials are treated by different preparation processes, so that the cordyceps militaris and dried orange peel teabags have high crude drug content, obvious effects of promoting urination, clearing damp, reducing uric acid, invigorating spleen and tonifying kidney, and do not damage vital qi. The product is a green functional food which can be taken for a long time, has no toxic or side effect and dependence, is suitable for a wide range of people and is convenient to eat. In addition, the embodiment of the invention has stable process, controllable quality and strong operability of each procedure through the special optimization treatment of the processing and preparation process of the raw materials, is completely suitable for large-scale production, and is a preparation method with unique innovation of the tea bag.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (3)

1. A preparation method of a traditional Chinese medicine composition with effects of invigorating spleen, tonifying kidney and/or reducing uric acid is characterized in that the traditional Chinese medicine composition is prepared from the following preparation raw materials in parts by weight: 85 to 100 parts of fried coix seeds, 60 to 75 parts of tuckahoe, 55 to 75 parts of Chinese yam, 95 to 105 parts of medlar, 65 to 80 parts of cordyceps militaris, 60 to 70 parts of kudzuvine roots, 10 to 18 parts of liquorice, 90 to 105 parts of fried buckwheat, 65 to 75 parts of lily, 10 to 15 parts of ampelopsis grossedentata and 13 to 18 parts of dried orange peel;
the preparation method comprises the steps of preparing the extract A1, the extract A2 and powder respectively, mixing the extract A1, the extract A2 and the powder and drying the obtained mixture; wherein:
the step of preparing extract A1 comprises: taking the fried coix seeds, the poria cocos and the Chinese yams, adding 8-10 times of water to extract for 1-3 times, each time for 0.5-1.5 hours, collecting water extract, concentrating the water extract at 70-80 ℃ to obtain water extract concentrated solution with the density of 1.02-1.08, precipitating the water extract concentrated solution with 0.8-1 time of ethanol solution with the volume concentration of 90-98%, collecting supernatant, and concentrating the supernatant;
the step of preparing extract A2 comprises: taking the medlar, the cordyceps militaris, the radix puerariae and the liquorice, adding 8-10 times of water to extract for 1-3 times, each time for 0.5-1.5 h, collecting water extract, and concentrating the water extract at 70-80 ℃;
the powder preparation method comprises the following steps: pulverizing the parched semen Fagopyri Esculenti, bulbus Lilii, ampelopsis grossedentata and pericarpium Citri Tangerinae;
the temperature adopted for drying is 70-80 ℃;
the size of the powder is controlled to be 10-12 meshes;
the traditional Chinese medicine composition is a tea bag.
2. The method for preparing a Chinese medicinal composition according to claim 1, wherein the extraction is carried out by soaking.
3. The preparation method of the traditional Chinese medicine composition according to claim 1 or 2, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 85 to 95 parts of fried coix seed, 60 to 65 parts of tuckahoe, 58 to 63 parts of yam, 98 to 102 parts of medlar, 65 to 70 parts of cordyceps militaris, 60 to 64 parts of kudzuvine root, 13 to 16 parts of liquorice, 90 to 100 parts of fried buckwheat, 65 to 70 parts of lily, 10 to 14 parts of ampelopsis grossedentata and 13 to 16 parts of tangerine peel.
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