CN104958364A - Production method for cowberry lutein preparation capable of relieving asthenopia - Google Patents
Production method for cowberry lutein preparation capable of relieving asthenopia Download PDFInfo
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Abstract
The invention discloses a production method for a cowberry lutein preparation capable of relieving asthenopia. The production method is characterized by comprising the following steps of adding beta carotene, lutein, starch and magnesium stearate in cowberry extracts; mixing the components; performing granulation; filling granules into capsules; performing polishing; and packaging the cowberry lutein preparation. Components of the raw materials of the cowberry lutein preparation are compatible scientifically, a perfect extraction effect is achieved, nutrient substances and biological activity of cowberries are maintained, and used technological steps and the used method are reasonable and scientific and are easy to operate. Precious resource compound is organically combined to the modern biotechnology, the asthenopia relieving effect of the cowberries is optimized, and according to characteristics of capsule formulation, a cowberry capsule preparation which can relieve the asthenopia, is absorbed by human bodies easily and is convenient to eat and carry is obtained.
Description
Technical field
The present invention relates to technical field of health care food, particularly a kind of Pericarpium Citri tangerinae xanthophyll preparation production method of alleviating asthenopia.
Background technology
Asthenopia is also known as eyestrain, and be the common a kind of disease of current ophthalmology, the symptom of patient is varied, and main manifestations is visual disorder, during as close eye, occurs that capable overlapping, the word of blurred vision, ghost image, word jumps; See near after when seeing again at a distance, need to see clearly gradually a moment.Eye symptom have eye sleepy, keep in dark place, eyelid is heavy, sour swollen sense or pain around difficulty in opening the eyes, eyeball and eye socket, shed tears, foreign body sensation, eye are dry and astringent, saccade etc., serious asthenopia patient also has General Symptoms in various degree, as headache, dizzy, unable, nausea and vomiting etc.Asthenopia is not independently disease, but based on patient's subjective symptoms, the syndrome that eye or whole body apparatus factors and psychologic factors are interweaved, and is often called as eyestrain's syndrome yet.Outside environmental elements causes asthenopic major reason, and as illumination is not enough or excessively strong, distribution of light sources is uneven or glimpse, and fixation object is too small, meticulous or unstable.Along with the development of modern science and technology, the increase of electronics applications, people concentrate one's energy to stare at electronic curtain for a long time, and asthenopia phenomenon is more and more serious.Therefore, have very large harm based on this disease of asthenopia, the research and development of developing a kind of alleviating asthenopia health food seem particularly important, are also one of study hotspot fields of field of health care food worker.
Pericarpium Citri tangerinae especially with effect of alleviating asthenopia significantly generally acknowledge by people, be a kind of there is the high nutrition of alleviating asthenopia, high medicinal pollution-free food.Cranberry subcircular, diameter mostly is 0.5-2cm, blue-black or peony.Pericarpium Citri tangerinae contains the Multiple components such as anthocyanin, pectin, tannin, arbutin, vitamin C and vitamin B group, can prevent angiorrhexis, also be described as the mechanic of blood capillary, and protection eyes, anti-canceration, is also improved effect etc. to chronic viral hepatitis B.Pericarpium Citri tangerinae is rich in anthocyanidin, coloring matter in Fructus vaccini vitis-idaeae anthocyanidin, be mainly anthocyanidin-2-glucoside, anthocyanidin-3-xyloside, anthocyanidin-3-galactoside, anthocyanidin-2-rhamnoside, Herba delphinii grandiflori-3-rhamnoside, Herba delphinii grandiflori-5-glucoside, the former delphinidin of 3-O-acyl, enidin-3,5 two glucosides and 3,3-, bis--acyl former flower extraction element etc.Fructus vaccini vitis-idaeae anthocyanidin is senior medicine intermediate, contributes to maintaining capillary integrity and stable collagen.Anthocyanidin is also strong antioxidant.Ripe cranberry is rich in flavonoids and is used as antioxidant anthocyanidin.Healthy People or the alone Pericarpium Citri tangerinae extract of visual disorder patient or take bata-carotene and vitamin E, obviously can improve noctovision simultaneously, very fast to dark reaction, after eye is exposed to light, comparatively fast can recover visual acuity.Pilot, driver, computer operater take Pericarpium Citri tangerinae extract, can effectively improve retina regulating power, alleviate light pollution and light stimulates the damage caused vision.Therefore say, Pericarpium Citri tangerinae intensive processing is made the Pericarpium Citri tangerinae preparation with alleviating asthenopia, will wide market prospect be had.
Summary of the invention
The object of the invention is the Pericarpium Citri tangerinae xanthophyll preparation production method that a kind of alleviating asthenopia is provided for the deficiencies in the prior art.
The technical solution adopted in the present invention:
A kind of Pericarpium Citri tangerinae xanthophyll preparation production method of alleviating asthenopia, it is characterized in that adding bata-carotene, phylloxanthin, starch with Pericarpium Citri tangerinae extract, through mixing, granulation, dry, granulate, add magnesium stearate to be again mixed evenly, then incapsulate, polishing, packaging, irradiation sterilization make, the percentage by weight of each component is: Pericarpium Citri tangerinae extract 40-60%, bata-carotene 15-25%, phylloxanthin 15-25%, starch 0-10%, magnesium stearate 0.1-1%.
Described Pericarpium Citri tangerinae extract be with Pericarpium Citri tangerinae, Fructus Mori, Radix Dauci Sativae for raw material through cleaning, rubbing, defibrination, degraded, filtration, homogenizing, spraying dry make, the percentage by weight of each component is: Pericarpium Citri tangerinae 60-80%, Fructus Mori 10-30%, Radix Dauci Sativae 5-15%.
Described Pericarpium Citri tangerinae, Fructus Mori, Radix Dauci Sativae adopt ripe fresh Pericarpium Citri tangerinae, ripe fresh Fructus Mori, fresh carrot.
Described rubbing is rubbed with tissue mashing machine.
Described defibrination is sent in colloid mill the Pericarpium Citri tangerinae after rubbing, Fructus Mori, Radix Dauci Sativae, adds 1 ~ 3 times of purifying waste water to raw material and carry out defibrination.
Described degraded is that the Pericarpium Citri tangerinae of defibrination, Fructus Mori, Radix Dauci Sativae serosity are put into reactor, adds water 3 ~ 7 times, is heated to 37 ~ 47 DEG C, add 0.1% ~ 1% pectase, and constant temperature stirs after 3 ~ 5 hours and is warming up to 90 DEG C of enzyme denaturing.
Described filtration be by degradation treatment after serosity adopt 1 ~ 3 layer of filtered through gauze.
Described homogenizing is that the Pericarpium Citri tangerinae serosity of filtration is carried out homogenizing process, make the further granular of its granule, by superhigh-voltage homogenizing machine make serosity pressure be 100-120mpa, temperature carries out homogenizing 2 times under being 50-65 DEG C of condition, makes its serosity refine to scale liquid.
Described mixing adopts conventional method, Pericarpium Citri tangerinae extract added bata-carotene, phylloxanthin, starch mix homogeneously, and incorporation time for being no less than 40 minutes, then after granulation, drying, granulate, adding magnesium stearate and is mixed evenly.
Described drying, mixing, granulation, filled capsules, polishing, packaging all adopt Conventional processing methods.
Raw material phylloxanthin in instant component, starch, magnesium stearate all have sale in market at home and abroad.
Pericarpium Citri tangerinae in instant component is rich in anthocyanidin, and the anthocyanidin in Pericarpium Citri tangerinae can activate retina, strengthening vision, prevents eyeball tired, has effect of alleviating asthenopia; Fructus Mori in component are sweet in flavor and cold in property, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent; The multiple nutrients material that Radix Dauci Sativae in component contains, all there is protective effect to eye health, especially abundant carotene, vitamin A is transformed into after being absorbed and used, vitamin A and protein can be combined into rhodopsin, and this thing is the important substance of the staff cell sense low light level of eye retina, simultaneously, vitamin A also can make epithelial cells mucus, prevents xerophthalmia; Bata-carotene in component is just as natural ocular liquid medicine; help the lubrication and the transparency that keep cornea; promote the health of eyes; the vision of eyes depends on the macula lutea on optical fundus; if do not have enough β-Radix Dauci Sativaes usually to go bail for protect and support; will be there is retrograde pathological changes in this position, namely aging, and vision can fail and even finally nyctalopia occur.This disease is mainly in old people, although medical circle thinks that this is old and feeble one performance, points out that this degeneration ophthalmic usually can be prevented by the enough β-Radix Dauci Sativaes of picked-up simultaneously; Phylloxanthin in component has important protective effect to the macula lutea in retina; protection eyes are not by phototoxis; delay the aging of eyes and prevent pathological changes: each component compatibility complements one another, brings out the best in each other, thus plays function of relieving visual fatigue, improving the efficacy of relieving visual fatigue of Pericarpium Citri tangerinae.
The invention has the beneficial effects as follows:
1, the raw material components compatibility science adopted, each component complements one another, brings out the best in each other, and shows through animal experiment, has the nutritional health function of alleviating asthenopia.
The technique such as the defibrination 2, adopted, degradation treatment, homogenizing, drying is modern food and field of medicaments process technology, Pericarpium Citri tangerinae degradation solution is carried out homogenizing process further, make the further granular of its granular cell, more perfect extraction remains cowberry blueberry nutrition material and biological activity, the processing step adopted and method rationally, science, be easy to operate.
3, the present invention by Pericarpium Citri tangerinae, Fructus Mori, Radix Dauci Sativae science is composite organically combines with modern biotechnology, optimize the efficacy of relieving visual fatigue of Pericarpium Citri tangerinae, utilize capsule formulation feature simultaneously, make a kind of have alleviating asthenopia, be easy to absorption of human body, edible and easy to carry Folium Vaccinii vitis-idaeae flavin capsule.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
By the fresh Pericarpium Citri tangerinae of maturation of gathering, ripe fresh Fructus Mori, fresh carrot is cleaned, by Pericarpium Citri tangerinae 70%, Fructus Mori 15%, the weight ratio of Radix Dauci Sativae 15% takes rear with organizing pulverizer to rub, send into again in colloid mill, add 2 times of purifying waste water to raw material and carry out defibrination, again the serosity of colloid defibrination is put into reactor, add water 5 times, be heated to 37 DEG C, add 0.5% pectase, constant temperature is warming up to 90 DEG C of enzyme denaturing after stirring 4 hours, again through vacuum 80 kPas, temperature 90 DEG C centrifugal degassed, then the serosity after degradation treatment is adopted 1 layer of filtered through gauze, again the serosity of filtration is carried out homogenizing process, make the further granular of its granule, serosity is made to be 120mpa at pressure by superhigh-voltage homogenizing machine, temperature is carry out homogenizing 2 times under 50 DEG C of conditions, its serosity is made to refine to scale liquid, then spraying dry makes Pericarpium Citri tangerinae extract 53 kilograms, for subsequent use,
Take bata-carotene 23 kilograms, phylloxanthin 20 kilograms, starch 3.5 kilograms, magnesium stearate 0.5 kilogram, for subsequent use;
By Pericarpium Citri tangerinae extract 53 kilograms, bata-carotene 23 kilograms, phylloxanthin 20 kilograms, starch 3.5 kilograms mixing, incorporation time, for being no less than 40 minutes, by mixed material pelletization, drying, granulate, adds magnesium stearate 0.5 kilogram again in dried particles, mix homogeneously, then incapsulate, polishing, packaging, irradiation sterilization preparation cost invention Folium Vaccinii vitis-idaeae flavin capsule.
Embodiment 2:
By the fresh Pericarpium Citri tangerinae of maturation of gathering, ripe fresh Fructus Mori, fresh carrot is cleaned, by Pericarpium Citri tangerinae 75%, Fructus Mori 20%, the weight ratio of Herba Spinaciae 10% takes rear with organizing pulverizer to rub, send into again in colloid mill, add 2 times of purifying waste water to raw material and carry out defibrination, again the serosity of colloid defibrination is put into reactor, add water 6 times, be heated to 47 DEG C, add 0.4% pectase, constant temperature is warming up to 90 DEG C of enzyme denaturing after stirring 3 hours, again through vacuum 80 kPas, temperature 90 DEG C centrifugal degassed, then the serosity after degradation treatment is adopted 1 layer of filtered through gauze, again the serosity of filtration is carried out homogenizing process, make the further granular of its granule, serosity is made to be 120mpa at pressure by superhigh-voltage homogenizing machine, temperature is carry out homogenizing 2 times under 50 DEG C of conditions, its serosity is made to refine to scale liquid, then spraying dry makes Pericarpium Citri tangerinae extract 55 kilograms, for subsequent use,
Take bata-carotene 21 kilograms, phylloxanthin 19 kilograms, starch 4.5 kilograms, magnesium stearate 0.5 kilogram, for subsequent use;
By Pericarpium Citri tangerinae extract 55 kilograms, bata-carotene 21 kilograms, phylloxanthin 19 kilograms, starch 4.5 kilograms mixing, incorporation time, for being no less than 40 minutes, by mixed material pelletization, drying, granulate, adds magnesium stearate 0.5 kilogram again in dried particles, mix homogeneously, then incapsulate, polishing, packaging, irradiation sterilization preparation cost invention Folium Vaccinii vitis-idaeae flavin capsule.
Embodiment 3:
By the fresh Pericarpium Citri tangerinae of maturation of gathering, ripe fresh Fructus Mori, fresh carrot is cleaned, by Pericarpium Citri tangerinae 65%, Fructus Mori 20%, the weight ratio of Herba Spinaciae 15% takes rear with organizing pulverizer to rub, send into again in colloid mill, add 2 times of purifying waste water to raw material and carry out defibrination, again the serosity of colloid defibrination is put into reactor, add water 4 times, be heated to 41 DEG C, add 0.3% pectase, constant temperature is warming up to 90 DEG C of enzyme denaturing after stirring 4 hours, again through vacuum 80 kPas, temperature 90 DEG C centrifugal degassed, then the serosity after degradation treatment is adopted 1 layer of filtered through gauze, again the serosity of filtration is carried out homogenizing process, make the further granular of its granule, serosity is made to be 120mpa at pressure by superhigh-voltage homogenizing machine, temperature is carry out homogenizing 2 times under 50 DEG C of conditions, its serosity is made to refine to scale liquid, then spraying dry makes Pericarpium Citri tangerinae extract 56 kilograms, for subsequent use,
Take bata-carotene 20 kilograms, phylloxanthin 21 kilograms, starch 2.7 kilograms, magnesium stearate 0.3 kilogram, for subsequent use;
By Pericarpium Citri tangerinae extract 56 kilograms, bata-carotene 20 kilograms, phylloxanthin 21 kilograms, starch 2.7 kilograms mixing, incorporation time, for being no less than 40 minutes, by mixed material pelletization, drying, granulate, adds magnesium stearate 0.3 kilogram again in dried particles, mix homogeneously, then incapsulate, polishing, packaging, irradiation sterilization preparation cost invention Folium Vaccinii vitis-idaeae flavin capsule.
Embodiment 4
The present invention confirms safety non-toxic through animal experiment, experimental result and conclusion as follows:
1) acute toxicity testing shows: according to acute toxicity dose grading standard, true border avirulence level;
2) Micronucleus test, sperm malformation test, Salmonella reversion test result are negative;
3) 30 days feeding trials: laboratory animal growing state is good, and hematological examination, biochemical analysis, main dirty body when histological indications, compared with matched group, is showed no exception, proves safety non-toxic of the present invention.
Embodiment 5
Set forth the beneficial effect of product of the present invention below by way of function test further, carry out according to the evaluation test method of alleviating asthenopia in " health food inspection and assessment technical specification ".
Folium Vaccinii vitis-idaeae flavin capsule asthenopia releasing function human feeding trial provided by the invention is reported as follows:
Materials and methods
1.1 samples and placebo: Folium Vaccinii vitis-idaeae flavin capsule No.1, No. 2, provide by the present inventor, completely the same in the two two packagings, outward appearance, color and luster and mouthfeel, one of them is Folium Vaccinii vitis-idaeae flavin capsule of the present invention, another is placebo, population service every day 2 times, each 1.
1.2 experimenter's mass selections are selected:
1.2.1 inclusive criteria: select long-term eye, vision fatiguability person, the age 10-14 year between young.Allly meet above-mentioned condition and voluntary participation ensure that cooperation person all can include test in.
1.2.2 exclusion standard;
1.2.2.1 do not meet the experimenter including age criterion in; To health food allergy sufferers.
1.2.2.2 infectious ocular disease person is suffered from, the inside and outside ophthalmic patient such as angle glue nebula, keratoconus.
1.2.2.3 suffer from fundus oculi disease or be associated with the diseases such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system.
1.2.2.4 take the article relevant with tested function in a short time, have influence on the judgement person to result.
1.2.2.5 other associated therapy visions of long-term taking medicine or use other Therapeutic Method, fail terminator.
1.2.2.6 do not take by regulation, or data is not congruent affects effect or safety judgement person.
1.3 test method; To adopt between self and group two kinds to control design, according to requirement that is random, double blinding, will inclusive criteria be met and ensure the volunteer of compatibility test, according to symptom, examination of visual acuity situation, considering that the factor such as age, sex is divided into test-meal group and matched group simultaneously.Test-meal group and matched group take sample or placebo by recommended dose,
2, observation index:
Every observation index in test-meal on-test and at the end of each to measure once.
2.1 safety indexes
2.1.1 general physical examination: the health inquiring and understand experimenter before test in detail, carries out the lab testing of conventional physical examination and necessity to all experimenters.
2.1.2 routine blood test: red blood cell count(RBC), numeration of leukocyte, content of hemoglobin mensuration etc.
2.1.3 routine urinalysis; PH value, thin etc. in vain.
2.1.4 stool routine examination; Worm's ovum inspection etc.
2.1.5 untoward reaction is observed.
2.2 efficiency index
2.2.1 observation of symptoms; Detailed inquiry asthenopia situation, the symptoms such as observation ophthalmalgia, ophthalmic bloated, photophobia, blurred vision, eye are dry and astringent, before and after test-meal, integrated value is added up by mild symptoms multiple integral (serious symptom 3 points, middle disease 2 points, mild 1 point), and improve (each symptom improves more than 1 point for improving) situation with regard to its symptom, observe the symptoms improvement rate.
2.2.2 visuognosis persistence test.
2.2.3 distant vision measures.
3. experimental data statistics: data results mean standard deviation represents, self pair data adopts paired t-test, between observation group and matched group under the prerequisite of homogeneity of variance, mean compares employing independent samples t-test, otherwise adopt t to check after meeting homogeneity of variance after carrying out variables transformations, if variance is still uneven, adopt rank test.Improvement rate is enumeration data, can use x
2inspection, the total number of cases of four fold table is less than 40, or when toatl proportion is equal to or greater than 40 but occurs that theoretical value is equal to or less than 1, uses exact method method instead.
4. result criterion
4.1 symptom is improved: the dry and astringent arbitrary symptom of ophthalmalgia, ophthalmic bloated, photophobia, blurred vision, eye is improved more than 1 point and 1 point and is improvement, without deterioration, namely 5 kinds of arbitrary improvement of symptom and other symptoms judge that symptom is improved.
4.2 is effective: symptom is improved and differed by more than before and after duration of photopic vision and equal 0.1, and has significance through statistical difference.
4.3 is invalid: do not reach effective standard.
4.4 reference indexs: eyesight improving rate.Improve comparatively to improve two behaviors before experiment after test-meal experiment, add up two groups and take the eyesight improving rate after tested material as with reference to index, reference index is not as to the whether effective criterion of asthenopia releasing function.
5. result
Double-blind method observation end is made known: take No. 1 person for Pericarpium Citri tangerinae phylloxanthin capsule of the present invention, takes No. 2 persons for placebo
5.1 ordinary circumstances: initial trial crowd test-meal group 53 example, matched group 53 example, matched group: male/female is 26/27, the age is 10.26 0.45 years old.Experimenter's spirit during test-meal, sleep, diet, defecation are normal.
5.2 safety observations.
5.2.1 routine urinalysis, stool routine examination, routine blood test
In table 1.Edible tested material is after 45 days, and test-meal group and matched group routine urinalysis, stool routine examination, routine blood test, all within normal range, point out Folium Vaccinii vitis-idaeae flavin capsule of the present invention to body health without obvious damage.
Routine blood test, routine urinalysis, stool routine examination situation of change before and after table 1 test-meal
5.2.2 non-obvious adverse reaction during test-meal.
5.3 functional observation
5.3.1 clinicing symptom observation
Be improved in clinical symptoms such as test-meal group ophthalmalgia after table 2,3. test, ophthalmic bloated, photophobia, blurred vision, eye are dry and astringent, obvious reduction before its symptom integral and test-meal, difference has and significantly changes (p<0.05); Compare with matched group, difference is significance (p<0.05) also.
Table 2 clinical symptoms integration is added up
* compare with matched group, p<0.05 well compares with self, P<0.05.
Table 3 clinical symptoms improves situation
5.3.2 observation of curative effect
From table 4, take tested material after 45 days, test-meal group clinical observation total effective rate is 81.13%, has significance (P<0.05) with matched group (20.75%) comparing difference
Table 4 clinical observation effect compares
* compare with matched group, P<0.05.
5.3.3 on the impact of duration of photopic vision
As seen from Table 5, after test, test-meal group duration of photopic vision improves 0.12 before comparatively testing, and the increase rate of duration of photopic vision and matched group is obvious increases, difference has significance (P<0.05).Illustrate that Folium Vaccinii vitis-idaeae flavin capsule is improved the effect of duration of photopic vision.
The change of table 5 duration of photopic vision
* compare with matched group, p<0.05 # compares with self, P<0.05.
5.3.4 on the impact of vision
From table 6, test-meal group test backsight force level and matched group front with test-meal compares, no significant difference (P>0.05).Test-meal group vision increase rate and improvement rate and matched group comparing difference are without significance (P>0.05).
Vision condition before and after table 6 Folium Vaccinii vitis-idaeae flavin capsule degree food
| Group | Before test-meal | After test-meal | |
| Matched group | Left eye | 4.71+0.26 | 4.72+0.26 |
| Matched group | Right eye | 4.73+0.22 | 4.74+0.23 |
| Test-meal group | Left eye | 4.73+0.24 | 4.76+0.23 |
| Test-meal group | Right eye | 4.72+0.26 | 4.75+0.25 |
The improvement situation of front and back vision tested by table 7
5.4 depigmentation rates
After test in 45 days, matched group has 0 routine experimenter cannot judge that effect is screened out because being interrupted to take by test product; Test-meal group has 0 routine experimenter cannot judge that effect is screened out because being interrupted to take by test product.Last efficiency test crowd matched group 53 example, test-meal group 53 example.In table 8.
Depigmentation rate tested by table 8
| Group | Matched group (example) | Test-meal group (example) |
| Before test-meal | 53 | 53 |
| Depigmentation number | 0 | 0 |
| Depigmentation rate | 0.00% | 0.00% |
6 brief summaries
Result of the test shows: take Folium Vaccinii vitis-idaeae flavin capsule of the present invention and have clear improvement to clinical symptoms such as ophthalmalgia, ophthalmic bloated, photophobia, blurred vision, eye are dry and astringent, before symptom integral and test-meal and matched group comparing difference have significance (P<0.05); After test, test-meal group duration of photopic vision improves 0.12 before comparatively testing, and duration of photopic vision increase rate and matched group is obvious increases, difference has significance (P<0.05); After test-meal, test-meal group vision increase rate and improvement rate and matched group comparing difference are without significance (P<0.05). and according to the judgment criteria specified in " health food inspection and assessment technical specification " (version in 2003), point out Folium Vaccinii vitis-idaeae flavin capsule of the present invention to have the effect of asthenopia releasing function.
Claims (5)
1. the Pericarpium Citri tangerinae xanthophyll preparation production method of an alleviating asthenopia, it is characterized in that adding bata-carotene, phylloxanthin, starch, magnesium stearate with Pericarpium Citri tangerinae extract, make through mixing, granulation, filled capsules, polishing, technology of the package, the percentage by weight of each component is: Pericarpium Citri tangerinae extract 35-55%, bata-carotene 15-25%, phylloxanthin 10-20%, starch 5-15%, magnesium stearate 1-3%.
2. the Pericarpium Citri tangerinae xanthophyll preparation production method of a kind of alleviating asthenopia according to claim 1, it is characterized in that described Pericarpium Citri tangerinae extract is take Pericarpium Citri tangerinae as primary raw material, Fructus Lycii, Flos Chrysanthemi are that adjuvant is made through clean, rubbing, defibrination, degraded, filtration, homogenizing, drying, and the percentage by weight of each component is: Pericarpium Citri tangerinae 70-80%, Fructus Lycii 10-20, Flos Chrysanthemi 3-10%.
3. the Pericarpium Citri tangerinae xanthophyll preparation production method of a kind of alleviating asthenopia according to claim 1, it is characterized in that described filtration be by degradation treatment after serosity adopt 1 ~ 3 layer of filtered through gauze.
4. the Pericarpium Citri tangerinae xanthophyll preparation production method of a kind of alleviating asthenopia according to claim 1, it is characterized in that described homogenizing is that the serosity of filtration is carried out homogenizing process, make the further granular of its granule, by superhigh-voltage homogenizing machine make serosity pressure be 100-120mpa, temperature carries out homogenizing 2 times under being 50-65 DEG C of condition, makes its serosity refine to scale liquid.
5. the Pericarpium Citri tangerinae xanthophyll preparation production method of a kind of alleviating asthenopia according to claim 1, it is characterized in that described degraded is that the Pericarpium Citri tangerinae of defibrination, Fructus Lycii, Flos Chrysanthemi serosity are put into reactor, add water 3 ~ 7 times, be heated to 37 ~ 47 DEG C, add 0.1% ~ 1% pectase, constant temperature stirs after 3 ~ 5 hours and is warming up to 90 DEG C of enzyme denaturing.
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Cited By (4)
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| CN105878573A (en) * | 2016-05-20 | 2016-08-24 | 王义明 | Composition for relieving visual fatigue |
| CN108619244A (en) * | 2018-07-12 | 2018-10-09 | 杭州光启医疗科技发展有限公司 | A kind of capsule and preparation method thereof for sight protection |
| CN113826894A (en) * | 2021-08-30 | 2021-12-24 | 成都营养屋健康科技有限公司 | Capsule for relieving visual fatigue and preparation method thereof |
| CN115918905A (en) * | 2023-02-17 | 2023-04-07 | 华北制药河北华维健康产业有限公司 | Vaccinium xanthophyll health food tablet with effect of relieving eye fatigue |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878573A (en) * | 2016-05-20 | 2016-08-24 | 王义明 | Composition for relieving visual fatigue |
| CN108619244A (en) * | 2018-07-12 | 2018-10-09 | 杭州光启医疗科技发展有限公司 | A kind of capsule and preparation method thereof for sight protection |
| CN113826894A (en) * | 2021-08-30 | 2021-12-24 | 成都营养屋健康科技有限公司 | Capsule for relieving visual fatigue and preparation method thereof |
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Application publication date: 20151007 |