CN108619244A - A kind of capsule and preparation method thereof for sight protection - Google Patents

A kind of capsule and preparation method thereof for sight protection Download PDF

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CN108619244A
CN108619244A CN201810766383.1A CN201810766383A CN108619244A CN 108619244 A CN108619244 A CN 108619244A CN 201810766383 A CN201810766383 A CN 201810766383A CN 108619244 A CN108619244 A CN 108619244A
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parts
capsule
sight protection
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oil
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扣璇
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Hangzhou Guang Kai Medical Science And Technology Development Co Ltd
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Hangzhou Guang Kai Medical Science And Technology Development Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The capsule and preparation method thereof that the invention discloses a kind of for sight protection.Include the raw material of following parts by weight：26 parts of carotenoid, 13 parts of vitamin A, 10 18 parts of vegetable oil, 8 12 parts of fish glue, 10 20 parts of natural plant extracts, 20 35 parts of starch, 0.2 1 parts of magnesium stearate.The capsule of sight protection prepared by the present invention, myopia can be prevented and treated, long-term consumption has no toxic side effect, and can be used as medicine use, also the health products that can be used as pre- Anti-myopic eye use, the active constituents of medicine of the present invention uses natural plant extracts cassia seed extract, mulberries extract and tribulus terrestris extraction, with carotenoid, vitamin A, vegetable oil and fish glue compatibility, enhance the performance of drug effect, and duration of efficacy is long.

Description

A kind of capsule and preparation method thereof for sight protection
Technical field
The invention belongs to vision correction health product technology fields, and in particular to a kind of capsule and its system for sight protection Preparation Method.
Background technology
Currently, with people's rhythm of life accelerate, the extensive use of electronic product, people's eyes stare at electronic curtain when Between it is increasingly longer, cause the crowd of myopia higher and higher, and be in rejuvenation trend development.The whole world has more than 500,000,000 according to statistics Myopia, simple myopia makes troubles to the life of patient, and high myopia, especially pathological myopia then may With various serious complication or even blinding.
At present to the pathogenesis of myopia still without clear.Have been used for it is clinical include mainly cholinergic receptor-blocking agent Ah Tropine, croak logical sequence Xiping and hypotensive agents object etc., for above-mentioned neurotransmitter, it was found that a batch to myopia has potential treatment work Drug such as dopamine-receptor stimulant, receptor antagonist, nicotinergic receptor receptor agents minister in ancient times, nitric oxide synthetase inhibit Agent river etc..However, since the effect of said medicine is only limited to zoopery, and intervention time is limited, in addition controls myopia The effect of it is still imprecise, therefore limit in clinical application.
The method that myopia is thoroughly effected a radical cure at present is operation method, and still, operation method has certain risk, if not Successfully there is the risk of blinding.And pre- Anti-myopic eye is just at crucial means, especially for the more teenager of eye, takes Health product capsule and tcm product are good research directions.However, current corrects defects of vision with the most curative effect of eye health products Difference, effect unobvious.
Patent 201110284569.1 discloses a kind of liver-clearing vision-improving health-care tea.It is the raw material system matched by following weight At：Semen Lablab Album 15~30, Radix Paeoniae Alba 10~20, Semen Cuscutae 10~20, the fruit of Chinese wolfberry 8~15, scouring rush 10~25, mulberry leaf 8~15, chrysanthemum 5~15, Prunella vulgaris 5~15, fructus viticis 15~30, the bark of ash 15~30, pipewort 8~15, plantain seed 5~15, mother-of-pearl 20~ 35, tribulus terrestris 20~35, antelope's horn 1~5, Radix Curcumae 5~15, aloe 1~5, radix rehmanniae preparata 10~20, great burdock achene 5~15, seed of feather cockscomb 10 ~20, tealeaves 20~30.The effect of although health protection tea clears liver and improve vision, still, complicated component, taste is relatively more strange, taste It is bad.
Patent 201510963918.0 discloses a kind of health food for having and alleviating visual fatigue and protecting visual function.Its Active ingredient includes following components by weight percentage：Xanthophyll-oil 20%~30%, red yeast rice 10%~20%, vitamin A 0.4%~1%, vitamin E 0.5%~1% and vegetable oil 48%~69.1%.Although the health food can alleviate regard it is tired Labor and blood fat-reducing blood pressure-decreasing, it is still, invalid for myopia, it can only prevent treat.
Invention content
The capsule and preparation method thereof that the purpose of the present invention is to provide a kind of for sight protection.
A kind of capsule for sight protection includes the raw material of following parts by weight：2-6 parts of carotenoid, vitamin A 1-3 parts, 10-18 parts of vegetable oil, 8-12 parts of fish glue, 10-20 parts of natural plant extracts, 20-35 parts of starch, magnesium stearate 0.2- 1 part.
The carotenoid be alpha-carotene, beta carotene, lutein, zeaxanthin, one kind in lycopene and More than one.
The vegetable oil is soybean oil, olive oil, peanut oil, tea oil, corn oil, fiery sesame oil, one kind in cottonseed oil or More than one.
The natural plant extracts are cassia seed extract, mulberries extract, one kind or one in tribulus terrestris extraction Kind or more.
The extracting method of the cassia seed extract is：Cassia seed 100g is weighed, is crushed, 40-60 mesh sieve is crossed, is added 50%-80% ethanol waters 1500mL impregnates 40-70min, is then fed into high pressure extraction device, is acted in 50-80Mpa high pressures Under be continuously circulated through the annular working gap of high pressure extraction device, circulation time continues 30-50min, after taking out HIGH PRESSURE TREATMENT Feed liquid, filtering recycle ethyl alcohol, are concentrated into paste and obtain cassia seed extract.
The extracting method of the mulberries extract is：Mulberries dry, pulverize to 40-60 mesh, 0.5% cellulase is added With 1% pectase, the distilled water of 15-25 times of parts by weight is added, stirs 8-16min, is uniformly mixed, liquid upon mixing Middle addition acetic acid, it is 4-5 to make the pH value of liquid, then is placed in 1-2h in 55-60 DEG C of water-bath；Liquid after water-bath is heated, Its 8-16min that boils, standing is set to take upper liquid, be centrifuged to upper liquid, take supernatant, be dried, obtain to the supernatant Obtain mulberries extract.
The extracting method of the tribulus terrestris extraction is：10kg tribulus terrestris is weighed, is crushed, is added 8kg water to mix wet, 20g is added to form sediment Powder enzyme and 30g pectases are uniformly mixed, and room temperature digests 4-6 days, and enzymolysis raw material puts into ultrasonic extraction tank, add 200L70% methanol super Sound extracts 2 hours, supersonic frequency 20kHz, power 1kw and filters out liquid, be heated to 50-60 DEG C, adds 500g activated carbon decolorizings 2 small When, activated carbon is filtered out, methanol is recycled, concentrate adds 2kg neutral aluminas to dry, and fills column, and 12L80% ethanol solutions is taken to elute, It collects eluent and ethyl alcohol is recovered under reduced pressure, concentrate is dried in vacuo to obtain faint yellow tribulus terrestris extraction.
The capsule further includes 1-3 parts of himalayan prinsepia leaf wood ester alcohol glycosides.
The preparation method of the capsule of above-mentioned sight protection, includes the following steps：
(1) according to parts by weight, 2-6 parts of carotenoid, 1-3 parts of vitamin A, 10-18 parts of vegetable oil, fish glue 8-12 are taken Part, 10-20 parts of natural plant extracts, 20-35 parts of starch stirs 20-40min, is uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 60-100 mesh；
(3) 0.2-1 parts of magnesium stearate is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.2- 0.8g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
Beneficial effects of the present invention：The capsule of sight protection prepared by the present invention can prevent and treat myopia, for a long time It is edible to have no toxic side effect, medicine use is can be used as, the health products that also can be used as pre- Anti-myopic eye use, drug of the invention Active constituent uses natural plant extracts cassia seed extract, mulberries extract and tribulus terrestris extraction, and carotenoid, Vitamin A, vegetable oil and fish glue compatibility, enhance the performance of drug effect, and duration of efficacy is long.
Specific implementation mode
With reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of capsule for sight protection includes the raw material of following parts by weight：Lutein 4g, vitamin A 2g, greatly Soya-bean oil 15g, fish glue 10g, cassia seed extract 5g, mulberries extract 5g, tribulus terrestris extraction 5g, starch 30g, magnesium stearate 0.5g。
The extracting method of the cassia seed extract is：Cassia seed 100g is weighed, is crushed, 50 mesh sieve is crossed, 70% second is added Alcohol solution 1500mL impregnates 60min, is then fed into high pressure extraction device, and height is continuously circulated through under the effect of 60Mpa high pressures It presses the annular working gap of extractor, circulation time to continue 40min, takes out the feed liquid after HIGH PRESSURE TREATMENT, ethyl alcohol is recycled in filtering, It is concentrated into paste and obtains cassia seed extract.
The extracting method of the mulberries extract is：Mulberries dry, pulverize to 50 mesh, be added 0.5% cellulase and 1% pectase adds the distilled water of 20 times of parts by weight, stirs 12min, is uniformly mixed, is added in liquid upon mixing Acetic acid, it is 4.5 to make the pH value of liquid, then is placed in 1.5h in 58 DEG C of water-baths；Liquid after water-bath is heated, its boiling is made 12min, standing take upper liquid, are centrifuged to upper liquid, take supernatant, which is dried, and obtain mulberries extraction Object.
The extracting method of the tribulus terrestris extraction is：10kg tribulus terrestris is weighed, is crushed, is added 8kg water to mix wet, 20g is added to form sediment Powder enzyme and 30g pectases are uniformly mixed, and room temperature digests 5 days, and enzymolysis raw material puts into ultrasonic extraction tank, add 200L70% methanol ultrasonic Extraction filters out liquid in 2 hours, supersonic frequency 20kHz, power 1kw, is heated to 55 DEG C, adds 500g activated carbon decolorizings 2 hours, filters Except activated carbon, methanol is recycled, concentrate adds 2kg neutral aluminas to dry, and fills column, and 12L80% ethanol solutions is taken to elute, and collection is washed Ethyl alcohol is recovered under reduced pressure in de- liquid, and concentrate is dried in vacuo to obtain faint yellow tribulus terrestris extraction.
The preparation method of the capsule of above-mentioned sight protection, includes the following steps：
(1) according to parts by weight, lutein 4g, vitamin A 2g, soybean oil 15g, fish glue 10g, cassia seed extract are taken 5g, mulberries extract 5g, tribulus terrestris extraction 5g, starch 30g stir 30min, are uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 80 mesh；
(3) magnesium stearate 0.5g is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.5g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
Embodiment 2
A kind of capsule for sight protection includes the raw material of following parts by weight：Beta carotene 1g, lutein 1g, dimension Raw element A 1g, olive oil 10g, fish glue 8g, cassia seed extract 2g, mulberries extract 2g, tribulus terrestris extraction 6g, starch 20g, Magnesium stearate 0.2g.
The extracting method of the cassia seed extract is：Cassia seed 100g is weighed, is crushed, 40 mesh sieve is crossed, 50% second is added Alcohol solution 1500mL impregnates 40min, is then fed into high pressure extraction device, and height is continuously circulated through under the effect of 50Mpa high pressures It presses the annular working gap of extractor, circulation time to continue 30min, takes out the feed liquid after HIGH PRESSURE TREATMENT, ethyl alcohol is recycled in filtering, It is concentrated into paste and obtains cassia seed extract.
The extracting method of the mulberries extract is：Mulberries dry, pulverize to 40 mesh, be added 0.5% cellulase and 1% pectase adds the distilled water of 15 times of parts by weight, stirs 8min, is uniformly mixed, second is added in liquid upon mixing Acid, it is 4 to make the pH value of liquid, then is placed in 1h in 55 DEG C of water-baths；Liquid after water-bath is heated, its 8min that boils is made, it is quiet It sets and takes upper liquid, upper liquid is centrifuged, take supernatant, which is dried, obtain mulberries extract.
The extracting method of the tribulus terrestris extraction is：10kg tribulus terrestris is weighed, is crushed, is added 8kg water to mix wet, 20g is added to form sediment Powder enzyme and 30g pectases are uniformly mixed, and room temperature digests 4 days, and enzymolysis raw material puts into ultrasonic extraction tank, add 200L70% methanol ultrasonic Extraction filters out liquid in 2 hours, supersonic frequency 20kHz, power 1kw, is heated to 50 DEG C, adds 500g activated carbon decolorizings 2 hours, filters Except activated carbon, methanol is recycled, concentrate adds 2kg neutral aluminas to dry, and fills column, and 12L80% ethanol solutions is taken to elute, and collection is washed Ethyl alcohol is recovered under reduced pressure in de- liquid, and concentrate is dried in vacuo to obtain faint yellow tribulus terrestris extraction.
The preparation method of the capsule of above-mentioned sight protection, includes the following steps：
(1) according to parts by weight, beta carotene 1g, lutein 1g, vitamin A 1g, olive oil 10g, fish glue 8g are taken, certainly Pine torch extract 2g, mulberries extract 2g, tribulus terrestris extraction 6g, starch 20g stir 20min, are uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 60 mesh；
(3) magnesium stearate 0.2g is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.2g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
Embodiment 3
A kind of capsule for sight protection includes the raw material of following parts by weight：Alpha-carotene 2g, beta carotene 2g, lycopene 2g, vitamin A 3g, tea oil 6g, corn oil 6g, fiery sesame oil 6g, fish glue 12g, cassia seed extract 5g, mulberries Extract 5g, tribulus terrestris extraction 10g, starch 35g, magnesium stearate 1g.
The extracting method of the cassia seed extract is：Cassia seed 100g is weighed, is crushed, 60 mesh sieve is crossed, 80% second is added Alcohol solution 1500mL impregnates 70min, is then fed into high pressure extraction device, and height is continuously circulated through under the effect of 80Mpa high pressures It presses the annular working gap of extractor, circulation time to continue 50min, takes out the feed liquid after HIGH PRESSURE TREATMENT, ethyl alcohol is recycled in filtering, It is concentrated into paste and obtains cassia seed extract.
The extracting method of the mulberries extract is：Mulberries dry, pulverize to 60 mesh, be added 0.5% cellulase and 1% pectase adds the distilled water of 25 times of parts by weight, stirs 16min, is uniformly mixed, is added in liquid upon mixing Acetic acid, it is 5 to make the pH value of liquid, then is placed in 2h in 60 DEG C of water-baths；Liquid after water-bath is heated, its 16min that boils is made, Standing takes upper liquid, is centrifuged to upper liquid, takes supernatant, which is dried, and obtains mulberries extract.
The extracting method of the tribulus terrestris extraction is：10kg tribulus terrestris is weighed, is crushed, is added 8kg water to mix wet, 20g is added to form sediment Powder enzyme and 30g pectases are uniformly mixed, and room temperature digests 6 days, and enzymolysis raw material puts into ultrasonic extraction tank, add 200L70% methanol ultrasonic Extraction filters out liquid in 2 hours, supersonic frequency 20kHz, power 1kw, is heated to 60 DEG C, adds 500g activated carbon decolorizings 2 hours, filters Except activated carbon, methanol is recycled, concentrate adds 2kg neutral aluminas to dry, and fills column, and 12L80% ethanol solutions is taken to elute, and collection is washed Ethyl alcohol is recovered under reduced pressure in de- liquid, and concentrate is dried in vacuo to obtain faint yellow tribulus terrestris extraction.
The preparation method of the capsule of above-mentioned sight protection, includes the following steps：
(1) according to parts by weight, alpha-carotene 2g, beta carotene 2g, lycopene 2g, vitamin A 3g, tea oil are taken 6g, corn oil 6g, fiery sesame oil 6g, fish glue 12g, cassia seed extract 5g, mulberries extract 5g, tribulus terrestris extraction 10g, starch 35g stirs 40min, is uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 100 mesh；
(3) magnesium stearate 1g is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.8g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
Embodiment 4
A kind of capsule for sight protection includes the raw material of following parts by weight：Lutein 4g, vitamin A 2g, greatly Soya-bean oil 15g, fish glue 10g, cassia seed extract 5g, mulberries extract 5g, tribulus terrestris extraction 5g, himalayan prinsepia leaf wood ester alcohol glycosides 2g, Starch 30g, magnesium stearate 0.5g.
The extracting method of the cassia seed extract is：Cassia seed 100g is weighed, is crushed, 50 mesh sieve is crossed, 70% second is added Alcohol solution 1500mL impregnates 60min, is then fed into high pressure extraction device, and height is continuously circulated through under the effect of 60Mpa high pressures It presses the annular working gap of extractor, circulation time to continue 40min, takes out the feed liquid after HIGH PRESSURE TREATMENT, ethyl alcohol is recycled in filtering, It is concentrated into paste and obtains cassia seed extract.
The extracting method of the mulberries extract is：Mulberries dry, pulverize to 50 mesh, be added 0.5% cellulase and 1% pectase adds the distilled water of 20 times of parts by weight, stirs 12min, is uniformly mixed, is added in liquid upon mixing Acetic acid, it is 4.5 to make the pH value of liquid, then is placed in 1.5h in 58 DEG C of water-baths；Liquid after water-bath is heated, its boiling is made 12min, standing take upper liquid, are centrifuged to upper liquid, take supernatant, which is dried, and obtain mulberries extraction Object.
The extracting method of the tribulus terrestris extraction is：10kg tribulus terrestris is weighed, is crushed, is added 8kg water to mix wet, 20g is added to form sediment Powder enzyme and 30g pectases are uniformly mixed, and room temperature digests 5 days, and enzymolysis raw material puts into ultrasonic extraction tank, add 200L70% methanol ultrasonic Extraction filters out liquid in 2 hours, supersonic frequency 20kHz, power 1kw, is heated to 55 DEG C, adds 500g activated carbon decolorizings 2 hours, filters Except activated carbon, methanol is recycled, concentrate adds 2kg neutral aluminas to dry, and fills column, and 12L80% ethanol solutions is taken to elute, and collection is washed Ethyl alcohol is recovered under reduced pressure in de- liquid, and concentrate is dried in vacuo to obtain faint yellow tribulus terrestris extraction.
The preparation method of the capsule of above-mentioned sight protection, includes the following steps：
(1) according to parts by weight, lutein 4g, dehydroretinol g, soybean oil 15g, fish glue 10g, cassia seed extract are taken 5g, mulberries extract 5g, tribulus terrestris extraction 5g, himalayan prinsepia leaf wood ester alcohol glycosides 2g, starch 30g stir 30min, are uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 80 mesh；
(3) magnesium stearate 0.5g is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.5g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
Embodiment 5
A kind of capsule for sight protection includes the raw material of following parts by weight：Lutein 4g, vitamin A 2g, greatly Soya-bean oil 15g, fish glue 10g, cassia seed extract 5g, mulberries extract 5g, tribulus terrestris extraction 5g, rumicin glycosides 2g, starch 30g, magnesium stearate 0.5g.
The extracting method of the cassia seed extract is：Cassia seed 100g is weighed, is crushed, 50 mesh sieve is crossed, 70% second is added Alcohol solution 1500mL impregnates 60min, is then fed into high pressure extraction device, and height is continuously circulated through under the effect of 60Mpa high pressures It presses the annular working gap of extractor, circulation time to continue 40min, takes out the feed liquid after HIGH PRESSURE TREATMENT, ethyl alcohol is recycled in filtering, It is concentrated into paste and obtains cassia seed extract.
The extracting method of the mulberries extract is：Mulberries dry, pulverize to 50 mesh, be added 0.5% cellulase and 1% pectase adds the distilled water of 20 times of parts by weight, stirs 12min, is uniformly mixed, is added in liquid upon mixing Acetic acid, it is 4.5 to make the pH value of liquid, then is placed in 1.5h in 58 DEG C of water-baths；Liquid after water-bath is heated, its boiling is made 12min, standing take upper liquid, are centrifuged to upper liquid, take supernatant, which is dried, and obtain mulberries extraction Object.
The extracting method of the tribulus terrestris extraction is：10kg tribulus terrestris is weighed, is crushed, is added 8kg water to mix wet, 20g is added to form sediment Powder enzyme and 30g pectases are uniformly mixed, and room temperature digests 5 days, and enzymolysis raw material puts into ultrasonic extraction tank, add 200L70% methanol ultrasonic Extraction filters out liquid in 2 hours, supersonic frequency 20kHz, power 1kw, is heated to 55 DEG C, adds 500g activated carbon decolorizings 2 hours, filters Except activated carbon, methanol is recycled, concentrate adds 2kg neutral aluminas to dry, and fills column, and 12L80% ethanol solutions is taken to elute, and collection is washed Ethyl alcohol is recovered under reduced pressure in de- liquid, and concentrate is dried in vacuo to obtain faint yellow tribulus terrestris extraction.
The preparation method of the capsule of above-mentioned sight protection, includes the following steps：
(1) according to parts by weight, lutein 4g, vitamin A 2g, soybean oil 15g, fish glue 10g, cassia seed extract are taken 5g, mulberries extract 5g, tribulus terrestris extraction 5g, rumicin glycosides 2g, starch 30g stir 30min, are uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 80 mesh；
(3) magnesium stearate 0.5g is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.5g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
Embodiment 6
A kind of capsule for sight protection includes the raw material of following parts by weight：Lutein 4g, vitamin A 2g, greatly Soya-bean oil 15g, fish glue 10g, coarse rising sun star flower extract 15g, starch 30g, magnesium stearate 0.5g.
The extracting method of the coarse rising sun star flower extract is：Weigh coarse rising sun star flower (Mentzelia asperaL.) 100g is crushed, and crosses 50 mesh sieve, and 70% ethanol water 1500mL is added and impregnates 60min, is then fed into high pressure extraction device, The annular working gap of high pressure extraction device is continuously circulated through under the effect of 60Mpa high pressures, circulation time continues 40min, takes out high Pressure treated feed liquid, filtering recycle ethyl alcohol, are concentrated into paste and obtain coarse rising sun star flower extract.
The preparation method of the capsule of above-mentioned sight protection, includes the following steps：
(1) according to parts by weight, lutein 4g, vitamin A 2g, soybean oil 15g, fish glue 10g, coarse rising sun star flower is taken to carry Object 15g, starch 30g are taken, 30min is stirred, is uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 80 mesh；
(3) magnesium stearate 0.5g is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.5g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
Embodiment 7
A kind of capsule for sight protection includes the raw material of following parts by weight：Lutein 4g, vitamin A 2g, greatly Soya-bean oil 15g, fish glue 10g, the lobus cardiacus rising sun star flower extract 15g, starch 30g, magnesium stearate 0.5g.
The extracting method of the lobus cardiacus rising sun star flower extract is：Weigh lobus cardiacus rising sun star flower (Mentzelia cordifolia Dombey) 100g is crushed, and crosses 50 mesh sieve, and 70% ethanol water 1500mL is added and impregnates 60min, is then fed into high pressure extraction In device, the annular working gap of high pressure extraction device is continuously circulated through under the effect of 60Mpa high pressures, circulation time continues 40min, The feed liquid after HIGH PRESSURE TREATMENT is taken out, filtering recycles ethyl alcohol, is concentrated into paste and obtains lobus cardiacus rising sun star flower extract.
The preparation method of the capsule of above-mentioned sight protection, includes the following steps：
(1) according to parts by weight, lutein 4g, vitamin A 2g, soybean oil 15g, fish glue 10g, lobus cardiacus rising sun star flower is taken to carry Object 15g, starch 30g are taken, 30min is stirred, is uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 80 mesh；
(3) magnesium stearate 0.5g is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.5g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
Embodiment 8
A kind of capsule for sight protection includes the raw material of following parts by weight：Lutein 4g, vitamin A 2g, greatly Soya-bean oil 15g, fish glue 10g, starch 30g, magnesium stearate 0.5g.
The preparation method of the capsule of above-mentioned sight protection, includes the following steps：
(1) according to parts by weight, lutein 4g, vitamin A 2g, soybean oil 15g, fish glue 10g, starch 30g are taken, is stirred 30min is uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 80 mesh；
(3) magnesium stearate 0.5g is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.5g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
Experimental example 1：
Experimental animal selects birth 13-14 days, and the C57BL/6 mouse for eyelid of not widening the view (from Beijing dimension tonneau China test by purchase Zoo technical Co., Ltd).
Experiment mice 90 is only randomly divided into 9 groups, control group is not processed, normal to feed, experimental mice (embodiment 1- 8) observation mouse opens eyelid situation, and optionally semi-transparent film eyeshade, semitransparent thin film resin viscose glue are worn at a glance on the day of opening eyelid It is pasted on to be cut on semiorbicular adhesive plaster and eyeshade is made, eyeshade is pasted on to the semi-circular plastic cement base for being sewn to mouse eye circumference in advance On seat, ensure eyelid normal activity.The sight protection capsule that 3g/kg is added in experimental mice feed, after 2 weeks, removal is semi-transparent Bright film eyeshade prepares optometry.
Semi-transparent film group goes after covering to carry out optometry, and on the day of eyelid suture group is gone after suture and each optometry in the 3rd day is primary. It is primary first with compound support to adjoin card amine eye drip before optometry, after five minutes i.e. abundant mydriasis.Using streak retinoscope retinoscopy optometry.Work Make distance 50cm, be averaged after measuring the number of degrees of horizontal and vertical axial direction respectively, every eye is singly blind by same position optist, again Repetition measurement amount 3 times.
With reference to the axis measurement method of Schaffel (2004) and Barathi (2008) etc..By the eyeball of fresh excision It lies against on levels operation platform, high power video camera is taken pictures after ophthalmic operating microscope amplifies, and gained unifies the photograph of amplification factor Piece is measured from corneal vertex to eyeball at a distance from optic nerve intersection, as axiallength.Each eyeball claps 3 photos, takes Average value.
Test result is shown in Table 1-2：
Each group mouse diopter (D) compares after table 12 weeks
Note：* compared with embodiment 1：P<0.05；* is compared with embodiment 1：P<0.01.
As can be seen from Table 1, embodiment 8 be not added with natural plant extracts group, compared with Example 1, two bend Luminosity difference pole is significantly higher than embodiment 1, it was demonstrated that natural plant extracts of the invention are the key component that must be added；Implement Two refraction of eye degree differences of example 2,3,7 are suitable, and the two refraction of eye degree differences of embodiment 4-5 are significantly higher than embodiment 1, embodiment 6 Two refraction of eye degree difference poles be significantly higher than embodiment 1, numerical value is suitable with control group.
Each group mouse axiallength (mm) compares after table 22 weeks
Note：* compared with embodiment 1：P<0.05；* is compared with embodiment 1：P<0.01.
As can be seen from Table 1, embodiment 8 is to be not added with natural plant extracts group, compared with Example 1, two eyes Shaft length difference pole is significantly higher than embodiment 1, it was demonstrated that natural plant extracts of the invention are the key component that must be added；It is real Two axiallength differences for applying example 2,3,7 are suitable, and two axiallength differences of embodiment 4-5 are significantly higher than embodiment 1, real Two axiallength difference poles for applying example 6 are significantly higher than embodiment 1, and numerical value is suitable with control group.

Claims (9)

1. a kind of capsule for sight protection, which is characterized in that include the raw material of following parts by weight：Carotenoid 2-6 Part, 1-3 parts of vitamin A, 10-18 parts of vegetable oil, 8-12 parts of fish glue, 10-20 parts of natural plant extracts, 20-35 parts of starch, 0.2-1 parts of magnesium stearate.
2. being used for the capsule of sight protection according to claim 1, which is characterized in that the carotenoid is α-carrot One kind in element, beta carotene, lutein, zeaxanthin, lycopene and more than one.
3. being used for the capsule of sight protection according to claim 1, which is characterized in that the vegetable oil is soybean oil, olive Oil, peanut oil, tea oil, corn oil, fiery sesame oil, the one or more in cottonseed oil.
4. being used for the capsule of sight protection according to claim 1, which is characterized in that the natural plant extracts are Cassia Seed extract, mulberries extract, the one or more in tribulus terrestris extraction.
5. being used for the capsule of sight protection according to claim 1, which is characterized in that the extraction side of the cassia seed extract Method is：Cassia seed 100g is weighed, is crushed, 40-60 mesh sieve is crossed, 50%-80% ethanol waters 1500mL is added and impregnates 40- 70min is then fed into high pressure extraction device, and the annular work of high pressure extraction device is continuously circulated through under the effect of 50-80Mpa high pressures Make gap, circulation time continues 30-50min, takes out the feed liquid after HIGH PRESSURE TREATMENT, and filtering recycles ethyl alcohol, is concentrated into paste and obtains Cassia seed extract.
6. being used for the capsule of sight protection according to claim 1, which is characterized in that the extracting method of the mulberries extract For：Mulberries dry, pulverize to 40-60 mesh, 0.5% cellulase and 1% pectase is added, adds 15-25 times of parts by weight Several distilled water stirs 8-16min, is uniformly mixed, acetic acid is added in liquid upon mixing, and it is 4-5 to make the pH value of liquid, then It is placed in 1-2h in 55-60 DEG C of water-bath；Liquid after water-bath is heated, makes its 8-16min that boils, standing takes upper liquid, right Upper liquid is centrifuged, and supernatant is taken, which is dried, and obtains mulberries extract.
7. being used for the capsule of sight protection according to claim 1, which is characterized in that the extraction side of the tribulus terrestris extraction Method is：10kg tribulus terrestris is weighed, crushes, adds 8kg water to mix wet, 20g amylase and 30g pectases is added to be uniformly mixed, room temperature enzymolysis 4-6 days, enzymolysis raw material put into ultrasonic extraction tank, adds 200L70% methanol ultrasonic extraction 2 hours, supersonic frequency 20kHz, power 1kw filters out liquid, is heated to 50-60 DEG C, adds 500g activated carbon decolorizings 2 hours, filters out activated carbon, recycles methanol, and concentrate adds 2kg neutral aluminas are dried, and column is filled, and 12L80% ethanol solutions is taken to elute, and collect eluent and ethyl alcohol is recovered under reduced pressure, concentrate is true Empty dry faint yellow tribulus terrestris extraction.
8. being used for the capsule of sight protection according to claim 1, which is characterized in that the capsule further includes himalayan prinsepia leaf wood ester 1-3 parts of alcohol glycosides.
9. the preparation method of the capsule of sight protection described in claim 1, which is characterized in that include the following steps：
(1) according to parts by weight, 2-6 parts of carotenoid is taken, 1-3 parts of vitamin A, 10-18 parts of vegetable oil, 8-12 parts of fish glue, 10-20 parts of natural plant extracts, 20-35 parts of starch stir 20-40min, are uniformly mixed；
(2) particle is made using dry granulating machine, manufactured grain diameter is 60-100 mesh；
(3) 0.2-1 parts of magnesium stearate is taken, the particle prepared with step (2) mixes, and fills capsule, per grain size capsule 0.2-0.8g；
(4) using polishing, the step of screening, inner packing enters bottle, outer packing, finished product is made, is put in storage after the assay was approved.
CN201810766383.1A 2018-07-12 2018-07-12 A kind of capsule and preparation method thereof for sight protection Withdrawn CN108619244A (en)

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