CN106924350A - Mulberry extract and preparation method and application thereof - Google Patents
Mulberry extract and preparation method and application thereof Download PDFInfo
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- CN106924350A CN106924350A CN201710225693.8A CN201710225693A CN106924350A CN 106924350 A CN106924350 A CN 106924350A CN 201710225693 A CN201710225693 A CN 201710225693A CN 106924350 A CN106924350 A CN 106924350A
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- 235000008708 Morus alba Nutrition 0.000 title claims abstract description 104
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 240000000249 Morus alba Species 0.000 title abstract description 11
- 238000000605 extraction Methods 0.000 title description 2
- 239000007788 liquid Substances 0.000 claims abstract description 40
- 239000000843 powder Substances 0.000 claims abstract description 34
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 24
- 108090000790 Enzymes Proteins 0.000 claims abstract description 21
- 102000004190 Enzymes Human genes 0.000 claims abstract description 21
- 229940088598 enzyme Drugs 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 16
- 239000012153 distilled water Substances 0.000 claims abstract description 15
- 239000006228 supernatant Substances 0.000 claims abstract description 11
- 108010059892 Cellulase Proteins 0.000 claims abstract description 9
- 229940106157 cellulase Drugs 0.000 claims abstract description 9
- 238000009835 boiling Methods 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims abstract description 5
- 241000218231 Moraceae Species 0.000 claims description 94
- 150000003254 radicals Chemical class 0.000 claims description 23
- 239000002775 capsule Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- 108010084185 Cellulases Proteins 0.000 claims description 2
- 102000005575 Cellulases Human genes 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 abstract description 3
- 238000010438 heat treatment Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 2
- 108010059820 Polygalacturonase Proteins 0.000 abstract 1
- 108010093305 exopolygalacturonase Proteins 0.000 abstract 1
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000005445 natural material Substances 0.000 description 5
- 239000012467 final product Substances 0.000 description 4
- 230000002000 scavenging effect Effects 0.000 description 4
- 230000002292 Radical scavenging effect Effects 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 229930014669 anthocyanidin Natural products 0.000 description 2
- 150000001452 anthocyanidin derivatives Chemical class 0.000 description 2
- 235000008758 anthocyanidins Nutrition 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 235000019750 Crude protein Nutrition 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000011122 softwood Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a preparation method of a mulberry extract, which comprises the following steps: drying the mulberry, and crushing to 60-80 meshes to obtain mulberry dry powder; adding mixed enzyme comprising cellulase and pectinase into mulberry dry powder, adding distilled water, stirring for 5-10min, and mixing uniformly, wherein the mass ratio of the mulberry dry powder to the mixed enzyme is 1g:2-3mg, and the material-liquid ratio of the mulberry dry powder to the distilled water is 1g:20-30 ml; adding acetic acid into the mixed liquid to make the pH value of the liquid be 4-5, and then placing the liquid in a water bath at 50-60 ℃ for 1-2 h; heating the water-bath liquid, boiling for 5-10min, standing to obtain supernatant, centrifuging, collecting supernatant, and drying to obtain Mori fructus extract. The invention also discloses a mulberry extract prepared by the method and application of the extract. The mulberry extract prepared by the invention can remove free radicals.
Description
Technical field
The present invention relates to biomedicine technical field, more particularly to a kind of mulberries extract and preparation method thereof and should
With.
Background technology
Mulberries also known as mulberry fruit, are fruits that moraceae plants mulberry tree is tied, and tasty mouthfeel is nutritious, rich in crude protein, Hu
Radish element, vitamin, amino acid and mineral matter and other components.Research shows that the material in mulberries has oxidation resistant effect, can
Free radical is removed, human body is protected from the damage of free radical.
Free radical, also known as free radical, is group or atom with uncoupled electron, free radical can by electro transfer, plus
Into matter interactions such as polysaccharide, amino acid, protein, nucleic acid, the lipids in the various ways and organism such as, dehydrogenation, cause
These material oxidative damages, further make meronecrosis or mutation.
How a kind of pure natural substance for removing free radical is provided, be radicals scavenging field problem demanding prompt solution it
One.
The content of the invention
The present invention solves the technical problem of a kind of mulberries extract and its preparation method and application is provided, can prepare
Go out pure natural mulberries extract, the extract has radicals scavenging function.
In order to solve the above technical problems, the present invention provides a kind of preparation method of mulberries extract, comprise the following steps：Will
Mulberries are dried, and are crushed to 60-80 mesh, obtain mulberries dry powder；Take mulberries dry powder, addition includes mixing for cellulase and pectase
And enzyme, distilled water is added, 5-10min is stirred, it is well mixed, wherein, mulberries dry powder is 1g with the mass ratio for mixing enzyme:2-
3mg, mulberries dry powder is 1g with the solid-liquid ratio of distilled water:20-30ml；Acetic acid is added in liquid upon mixing, makes the pH of liquid
It is 4-5 to be worth, then is placed in 1-2h in 50-60 DEG C of water-bath；Liquid after water-bath is heated, makes its boiling 5-10min, standing takes
Upper liquid, is centrifuged to upper liquid, takes supernatant, and the supernatant is dried, and obtains mulberries extract.
Wherein, enzyme is mixed by mass percentage, including component：70-80% cellulases, 20-30% pectases.
Wherein, mulberries dry powder is 70 mesh.
Wherein, mulberries dry powder and the mass ratio for mixing enzyme are 1g:2.5mg, mulberries dry powder is 1g with the solid-liquid ratio of distilled water:
25ml。
Wherein, after adding acetic acid, the pH value of liquid is 4.5.
Wherein, enzyme is mixed by mass percentage, including component：75% cellulase, 25% pectase.
In order to solve the above technical problems, the present invention provides the mulberries extract that a kind of above-mentioned preparation method is prepared.
In order to solve the above technical problems, the present invention provides a kind of mulberries extract as removing free radical medicine or health products
Application.Specifically, mulberries extract is tablet, capsule, granule as the formulation for removing free radical medicine or health products
Or powder.
The beneficial effects of the invention are as follows：It is different from the situation of prior art, the preparation method of mulberries extract of the invention,
Comprise the following steps：Mulberries are dried, and is crushed to 60-80 mesh, obtain mulberries dry powder；Mulberries dry powder is taken, addition includes fiber
The mixing enzyme of plain enzyme and pectase, adds distilled water, stirs 5-10min, is well mixed, wherein, mulberries dry powder with mix enzyme
Mass ratio be 1g:2-3mg, mulberries dry powder is 1g with the solid-liquid ratio of distilled water:20-30ml；Added in liquid upon mixing
Acetic acid, makes the pH value of liquid for 4-5, then be placed in 1-2h in 50-60 DEG C of water-bath；Liquid after water-bath is heated, it is boiled
5-10min is risen, standing takes upper liquid, upper liquid is centrifuged, and takes supernatant, and the supernatant is dried, and obtains mulberries
Extract.Mulberries extract prepared by above-mentioned preparation method is pure natural substance, and free radical can be purged.Above-mentioned preparation side
Method has the characteristics that：Simply, it is easy to operate；Due to fully being crushed to morular cell, preferably the material in mulberries can be carried out
Extract；Suitable pH value can improve the recovery rate of mulberries extract；The mulberries extract prepared has recovery rate higher, and
It is nontoxic, harmless.
Specific embodiment
Embodiment 1
The preparation method of mulberries extract is comprised the following steps：Mulberries are dried, and is crushed to 70 mesh, obtain mulberries dry powder；Take
Mulberries dry powder, addition includes the mixing enzyme of cellulase and pectase, adds distilled water, stirs 8min, is well mixed, its
In, mulberries dry powder is 1g with the mass ratio for mixing enzyme:2.5mg, mulberries dry powder is 1g with the solid-liquid ratio of distilled water:25ml；Mixed
Acetic acid is added in liquid after conjunction, makes the pH value of liquid be 4.5, then be placed in 1.5h in 55 DEG C of water-baths；Liquid after water-bath is entered
Row heating, makes its boiling 8min, and standing takes upper liquid, upper liquid is centrifuged, and takes supernatant, and the supernatant is done
It is dry, obtain mulberries extract.
In the present embodiment, enzyme is mixed by mass percentage, including component：75% cellulase, 25% pectase.
The mulberries extract of the present embodiment can be purged to free radical, because it is pure natural substance, to human body without pair
Effect.
Embodiment 2
The preparation method of mulberries extract is comprised the following steps：Mulberries are dried, and is crushed to 70 mesh, obtain mulberries dry powder；Take
Mulberries dry powder, addition includes the mixing enzyme of cellulase and pectase, adds distilled water, stirs 8min, is well mixed, its
In, mulberries dry powder is 1g with the mass ratio for mixing enzyme:2.2mg, mulberries dry powder is 1g with the solid-liquid ratio of distilled water:22ml；Mixed
Acetic acid is added in liquid after conjunction, makes the pH value of liquid be 4.5, then be placed in 1.5h in 50 DEG C of water-baths；Liquid after water-bath is entered
Row heating, makes its boiling 8min, and standing takes upper liquid, upper liquid is centrifuged, and takes supernatant, and the supernatant is done
It is dry, obtain mulberries extract.
In the present embodiment, enzyme is mixed by mass percentage, including component：70% cellulase, 30% pectase.
The mulberries extract of the present embodiment can be purged to free radical, because it is pure natural substance, to human body without pair
Effect.
Embodiment 3
The preparation of mulberries extract tablet：Mulberries extract single-punch tablet press prepared by embodiment 1 or embodiment 2 is broken into directly
Footpath is 7mm, and weight is the piece of 350mg, obtains final product mulberries extract tablet.
Embodiment 4
The preparation of mulberries extract capsule：Mulberries extract prepared by embodiment 1 or embodiment 2 is packed into No. 1 with 350mg
Capsulae enterosolubilis, obtains final product mulberries extract capsule.
Embodiment 5
The preparation of mulberries extract granule：Mulberries extract prepared by embodiment 1 or embodiment 2 is added water and is made softwood, mistake
15 mesh sieves are granulated, and mulberries extract granule is obtained final product after drying.
Embodiment 6
The preparation of mulberries extract powder：Mulberries extract prepared by embodiment 1 or embodiment 2 is crossed into 250 mesh sieves, mulberries are obtained final product
Extract powder.
Below by the radicals scavenging effect of description of test mulberries extract of the present invention.
DPPH（1,1- diphenyl -2- trinitrophenyl-hydrazines）It is a kind of organic free radical of stabilization, its ethanol solution is in purple,
There is strong absorption at wavelength 517nm.In the presence of having free radical scavenger, the lone pair electrons of DPPH are paired, so that its
Fade, fading extent receives electronics in quantitative relationship with it, therefore available colorimetric method carries out quantitative analysis.Below with DPPH for
The radicals scavenging effect of bright mulberries extract.
Mulberries extract prepared by mulberries extract prepared by embodiment 1, embodiment 2, VC distilled water are configured to molten
Liquid, concentration is：10mg/L、20mg/L、30mg/L、40mg/L、50mg/L；DPPH is configured to 2 × 10 using absolute ethyl alcohol- 4The solution of mol/L；The sample solution to be measured and DPPH solution of same volume are taken, is well mixed, 20min, Yu Bo are placed at room temperature
Mensuration absorbance A at 517nm longi；The sample solution to be measured and absolute ethyl alcohol of same volume are taken, is well mixed, placed at room temperature
20min, the mensuration absorbance A at wavelength 517nmj；The DPPH solution and absolute ethyl alcohol of same volume are taken, is well mixed, room temperature
Lower placement 20min, the mensuration absorbance A at wavelength 517nmc；Calculate the free radical scavenging activity of each testing sample, clearance rate=[1-
（Ai-Aj）/Ac]×100%。
With sample solution concentration to be measured as abscissa, clearance rate is that ordinate draws curve, according to the linear regression of curve
Equation, calculates the mulberries extract of the preparation of embodiment 1, the semi-inhibit of mulberries extract removing free radical prepared by embodiment 2 dense
Degree（IC50）.
Experimental result：The IC of mulberries extract prepared by embodiment 150It is 7.80mg/L, mulberries prepared by embodiment 2 are extracted
The IC of thing50It is 7.82mg/L.According to experimental result, it can be seen that mulberries extract prepared by embodiment 1 and embodiment 2 has strong
Radical scavenging activity.Moved towards according to curve, when concentration is 40-50mg/L, curve tends to be steady and has a downtrend,
When concentration be 45mg/L when, embodiment 1 prepare mulberries extract, embodiment 2 prepare mulberries extract, VC free radical it is clear
Except rate reaches maximum, respectively 98%, 97.5%, 85%, according to the above results, it can be seen that prepared by embodiment 1 and embodiment 2
The free radical maximal clearance of mulberries extract is big compared with VC, i.e., the mulberries extract that prepared by embodiment 1 and embodiment 2 substantially can
Remove all of free radical.
IC of the mulberries anthocyanidin to radical scavenging activity is calculated using above-mentioned experimental technique50, by calculating, IC50It is worth and is
12.33mg/L.According to result of calculation, it can be seen that mulberries extract prepared by embodiment 1 or embodiment 2 has compared with mulberries anthocyanidin
There is more preferable radical scavenging activity.
In sum, mulberries extract of the invention can be purged to free radical, and it is pure natural substance, to human body
Have no side effect.
Embodiments of the invention are the foregoing is only, the scope of the claims of the invention is not thereby limited, it is every to utilize this hair
The equivalent transformation that bright description is made, or other related technical fields are directly or indirectly used in, similarly it is included in
In scope of patent protection of the invention.
Claims (9)
1. a kind of preparation method of mulberries extract, it is characterised in that comprise the following steps：
Mulberries are dried, and is crushed to 60-80 mesh, obtain mulberries dry powder；
The mulberries dry powder is taken, addition includes the mixing enzyme of cellulase and pectase, adds distilled water, stirs 5-10min,
It is well mixed, wherein, the mulberries dry powder is 1g with the mass ratio for mixing enzyme:The material of 2-3mg, the mulberries dry powder and distilled water
Liquor ratio is 1g:20-30ml；
Acetic acid is added in liquid upon mixing, makes the pH value of liquid for 4-5, then be placed in 1-2h in 50-60 DEG C of water-bath；
Liquid after water-bath is heated, makes its boiling 5-10min, standing takes upper liquid, upper liquid is centrifuged, takes
Clear liquid, is dried to the supernatant, obtains mulberries extract.
2. the preparation method of mulberries extract according to claim 1, it is characterised in that the mixing enzyme presses quality percentage
Than meter, including component：70-80% cellulases, 20-30% pectases.
3. the preparation method of mulberries extract according to claim 2, it is characterised in that the mulberries dry powder is 70 mesh.
4. the preparation method of mulberries extract according to claim 2, it is characterised in that the mulberries dry powder with mix enzyme
Mass ratio be 1g:2.5mg, the mulberries dry powder is 1g with the solid-liquid ratio of distilled water:25ml.
5. the preparation method of mulberries extract according to claim 2, it is characterised in that after adding acetic acid, the pH of liquid
Be worth is 4.5.
6. the preparation method of mulberries extract according to claim 2, it is characterised in that the mixing enzyme presses quality percentage
Than meter, including component：75% cellulase, 25% pectase.
7. the mulberries extract that the preparation method described in claim 1-6 any one is prepared.
8. the mulberries extract described in claim 7 is used as the application for removing free radical medicine or health products.
9. application according to claim 9, it is characterised in that the mulberries extract is used as removing free radical medicine or guarantor
The formulation of strong product is tablet, capsule, granule or powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710225693.8A CN106924350B (en) | 2017-04-07 | 2017-04-07 | Mulberry extract and preparation method and application thereof |
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|---|---|---|---|
| CN201710225693.8A CN106924350B (en) | 2017-04-07 | 2017-04-07 | Mulberry extract and preparation method and application thereof |
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| CN106924350A true CN106924350A (en) | 2017-07-07 |
| CN106924350B CN106924350B (en) | 2020-08-11 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107927784A (en) * | 2017-12-15 | 2018-04-20 | 齐鲁工业大学 | Fruit mulberry soaks warehouse paste manufacture process optimizing research |
| CN108619244A (en) * | 2018-07-12 | 2018-10-09 | 杭州光启医疗科技发展有限公司 | A kind of capsule and preparation method thereof for sight protection |
| CN108751431A (en) * | 2018-06-25 | 2018-11-06 | 袁野 | A kind of sewage treatment flocculating agent |
| CN113842406A (en) * | 2021-10-20 | 2021-12-28 | 兰州大学 | Application of mulberry aqueous extract in preparation of medicine for treating Alzheimer's disease |
| CN115337335A (en) * | 2022-08-19 | 2022-11-15 | 广州市科贝思生物技术有限公司 | Preparation method and application of mulberry extract with anti-saccharification effect |
-
2017
- 2017-04-07 CN CN201710225693.8A patent/CN106924350B/en active Active
Non-Patent Citations (1)
| Title |
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| 吕春玲等: "响应面试验优化桑葚汁复合酶解制备工艺及微滤技术对其品质的影响", 《食品科学》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107927784A (en) * | 2017-12-15 | 2018-04-20 | 齐鲁工业大学 | Fruit mulberry soaks warehouse paste manufacture process optimizing research |
| CN108751431A (en) * | 2018-06-25 | 2018-11-06 | 袁野 | A kind of sewage treatment flocculating agent |
| CN108619244A (en) * | 2018-07-12 | 2018-10-09 | 杭州光启医疗科技发展有限公司 | A kind of capsule and preparation method thereof for sight protection |
| CN113842406A (en) * | 2021-10-20 | 2021-12-28 | 兰州大学 | Application of mulberry aqueous extract in preparation of medicine for treating Alzheimer's disease |
| CN115337335A (en) * | 2022-08-19 | 2022-11-15 | 广州市科贝思生物技术有限公司 | Preparation method and application of mulberry extract with anti-saccharification effect |
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| CN106924350B (en) | 2020-08-11 |
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