CN103263375A - Mouthrinse containing extract and preparation method of mouthrinse - Google Patents
Mouthrinse containing extract and preparation method of mouthrinse Download PDFInfo
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- CN103263375A CN103263375A CN2013102084933A CN201310208493A CN103263375A CN 103263375 A CN103263375 A CN 103263375A CN 2013102084933 A CN2013102084933 A CN 2013102084933A CN 201310208493 A CN201310208493 A CN 201310208493A CN 103263375 A CN103263375 A CN 103263375A
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Abstract
The invention relates to the technical field of oral cleaning and nursing supplies, in particular to mouthrinse containing a notoginseng extract and a preparation method of the mouthrinse. The mouthrinse is obtained by mixing 0.1%-1.5% of the notoginseng extract, 12-35% of a moisturizing agent, 0.8%-2.5% of a surfactant, 0.1-0.5% of a sweetener, 0.5%-1% of a flavoring agent, 0.01-0.15% of a preservative, 0.1-0.2% of sodium pyrophosphate, 0.05-0.15% of sodium fluoride and the balance of deionized water by weight percentage through stirring. The mouthrinse is simple in process, easy to produce, safe and reliable, and has obvious antiphlogistic, hemostatic and anti-caries effects.
Description
Technical field
The present invention relates to the oral cleaning nursing article technical field, especially a kind of collutory that contains Radix Notoginseng extract and preparation method thereof.
Background technology
Radix Notoginseng has another name called Radix Notoginseng, it is a jewel in the Chinese crude drug that the Ming Dynasty famous pharmacy man Li Shizhen (1518-1593 A.D.) is called " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) " Radix Notoginseng, put down in writing in Qing Dynasty's pharmacy works supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying first; Radix Notoginseng enriches blood first; flavor with and merit also waits; die into Radix Ginseng, Radix Notoginseng, be the most precious person in the Chinese medicine." Chinese patent medicine " YUNNAN BAIYAO " and " Pien Tze Huang " of the China and foreign countries of becoming famous, namely be that primary raw material is made with the Radix Notoginseng, Radix Notoginseng is Araliaceae, stem, leaf, flower, all can be used as medicine.Radix Notoginseng has effects such as hemostasis, diffusing blood, analgesic therapy in Chinese herbal medicine.Arasaponin is one of main effective ingredient of Radix Notoginseng; Collutory is indispensable oral cavity cleaning hygienic article in people's daily life, and basic function is cleaning teeth, and fresh breath reaches the purpose that keeps oral cavity cleaning.In recent years, because the consumer healthcare realizes enhancing, collutory has been proposed more requirement, some auxiliary prevention oral diseases except cleaning the teeth, have also been increased, there is the function of nursing role in the oral cavity, and therefore, the product that has various functions both at home and abroad in the collutory becomes the market mainstream, again because the Chinese medicinal plant active component has the incomparable advantages of Western medicine such as natural, safe, so become the emphasis of current development on the market with the functional type collutory of active ingredient of Chinese herbs.In recent years, along with the development of modernization of Chinese medicine technology, the method for active ingredient of Chinese herbs research and utilization has also been obtained good development, this utilizes active ingredient of Chinese herbs to assist the prevention oral disease that good technical support is provided to collutory.
Summary of the invention
It is simple, easy to manufacture, safe and reliable and have a collutory of obvious antiinflammatory, hemostasis, dental caries effect that the problem to be solved in the present invention provides a kind of not only technology.
For solving the above problems, the present invention by the following technical solutions:
A kind of collutory that contains Radix Notoginseng extract, be made up of following component by weight percentage: Radix Notoginseng extract 0.1%～1.5%, wetting agent 12%～35%, surfactant 0.8%～2.5%, sweeting agent 0.01%～0.5%, flavouring agent 0.5%～1%, antiseptic 0.01 ~ 0.15%, tetrasodium pyrophosphate 0.1 ~ 0.2%, sodium fluoride 0.05 ~ 0.15% surplus are deionized water.
Further:Described Radix Notoginseng extract is one or more in arasaponin, stem and leaf of Radix Notoginseng saponin, the flower of Radix Notoginseng glycosides; Wetting agent is one or more in sorbitol, glycerol, propylene glycol, the xylitol; Surfactant is one or more among alkyl polyglucoside, sodium lauryl sulphate, tween 80, Tween-60, the castor oil hydrogenated RH-40; Sweeting agent is one or more in saccharin sodium, aspartame, the sucralose; Antiseptic is one or more in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben, the sodium benzoate.
Further:Described flavouring agent is one or more in Herba Menthae Ilicis Purpureae odor type, mint aroma, lemon flavor, green apple odor type, the composite fruit odor type.
A kind of method that contains the collutory of Radix Notoginseng extract, press significant percentage with Radix Notoginseng extract 0.1%～1.5%, wetting agent 12%～35%, surfactant 0.8%～2.5%, sweeting agent 0.01%～0.5%, flavouring agent 0.5%～1%, antiseptic 0.01 ~ 0.15%, tetrasodium pyrophosphate 0.1 ~ 0.2%, sodium fluoride 0.05 ~ 0.15% surplus are deionized water, mix, obtain collutory by stirring.
Further:Described Radix Notoginseng extract is one or more in arasaponin, stem and leaf of Radix Notoginseng saponin or the flower of Radix Notoginseng glycosides.
Further:Described wetting agent is one or more in sorbitol, glycerol, propylene glycol, the xylitol.
Further:Described surfactant is one or more among alkyl polyglucoside, sodium lauryl sulphate, tween 80, Tween-60, the castor oil hydrogenated RH-40.
Further:Described sweeting agent is one or more in saccharin sodium, aspartame, the sucralose.
Further:Described flavouring agent is one or more in Herba Menthae Ilicis Purpureae odor type, mint aroma, lemon flavor, green apple odor type, the composite fruit odor type.
Further:Described antiseptic is one or more in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben, the sodium benzoate.
Useful technique effect:
The present invention is added on Radix Notoginseng total arasaponins, stem and leaf of Radix Notoginseng saponin, flower of Radix Notoginseng saponin in the collutory as the hemostasis main component first, the anti-caries composition of sodium fluoride is added in the collutory, and successfully explore the arasaponin composition and add separately or the composite effective proportioning that is added in the collutory, effective interpolation scope is provided.Except cleaning the teeth, add the collutory of Radix Notoginseng and sodium fluoride, obviously improved antiinflammatory, hemostasis, the dental caries ability of collutory, can alleviate gingival swelling and pain, gingival hemorrhage, etc. oral problem;
Radix Notoginseng main product Yunnan, two places, Guangxi, about 80,000 mu of the annual cultivated area of Yunnan mountain of papers, output accounts for 95% of national output.Modern pharmacological research shows that Radix Notoginseng has effects such as tangible hemostasis, antiinflammatory.The present invention mainly utilizes pharmacological effects such as the antiinflammatory, hemostasis, anti-caries of Radix Notoginseng, sodium fluoride, Radix Notoginseng extract, sodium fluoride are added in the collutory as the active component of the compositions of collutory, through the test chamber test of pesticide effectiveness, the present invention has outside the merit that cleans the teeth of common collutory, also have comparatively remarkable efficacy such as the periodontitis of preventing, gingivitis, oral ulcer, have tangible public health value and commercial value.
The specific embodiment:
Further specify flesh and blood of the present invention with test example of the present invention and embodiment below, but do not limit the present invention with this.
Embodiment 1:
A kind of collutory that contains Radix Notoginseng extract, be made up of following component by weight percentage: 0.2% arasaponin, 20% sorbitol, 10% glycerol, 1% castor oil hydrogenated RH-40,0.01% saccharin sodium, 0.5% composite fruit odor type flavouring agent, 0.1% sodium benzoate, 0.1% sodium fluoride, 0.1% tetrasodium pyrophosphate, surplus is deionized water.
Embodiment 2:
A kind of collutory that contains Radix Notoginseng extract, be made up of following component by weight percentage: 25% sorbitol, 10% glycerol, 1.2% tween 80,0.5% Tween-60,0.2% tetrasodium pyrophosphate, 0.05% sodium benzoate, 0.35% stem and leaf of Radix Notoginseng saponin, 0.7% green apple flavouring agent, 0.05% saccharin sodium, 0.15% sodium fluoride, surplus is deionized water.
Embodiment 3:
A kind of collutory that contains Radix Notoginseng extract, be made up of following component by weight percentage: 25% sorbitol, 10% propylene glycol, 1.2% alkyl polyglucoside, 0.15% tetrasodium pyrophosphate, 0.01% ethyl hydroxybenzoate, 1.5% flower of Radix Notoginseng saponin, 0.1% aspartame, 1% lemon flavor flavouring agent, 0.05% sodium fluoride, surplus is deionized water.
Embodiment 4:
A kind of collutory that contains Radix Notoginseng extract, be made up of following component by weight percentage: 20% glycerol, 15% xylitol, 1.2% alkyl polyglucoside, 0.2% tetrasodium pyrophosphate, 0.01% propylparaben, 0.5% flower of Radix Notoginseng saponin, 0.08% aspartame, 1% mint aroma flavouring agent, 0.1% sodium fluoride, surplus is deionized water.
Embodiment 5:
A kind of collutory that contains Radix Notoginseng extract, be made up of following component by weight percentage: xylitol 25%, propylene glycol 10%, 0.8% SDS, 0.2% tetrasodium pyrophosphate, butoben 0.01%, arasaponin 1.2%, 0.5% sucralose, 1% Herba Menthae Ilicis Purpureae flavouring agent, 0.1% sodium fluoride, surplus is deionized water.
Embodiment 6:
A kind of collutory that contains Radix Notoginseng extract, be made up of following component by weight percentage: 10% xylitol, 2% Sorbitol, 1% SDS, 0.1% tetrasodium pyrophosphate, 0.15% methyl hydroxybenzoate, 0.8% stem and leaf of Radix Notoginseng saponin, 0.01% saccharin sodium, 0.7% composite fragrant flavouring agent, 0.1% sodium fluoride, surplus is deionized water.
Embodiment 7:
A kind of method that contains the collutory of Radix Notoginseng extract, formed by following component by weight percentage: 0.2% arasaponin, 20% sorbitol, 10% glycerol, 1% castor oil hydrogenated RH-40,0.01% saccharin sodium, 0.5% composite fruit odor type flavouring agent, 0.1% sodium benzoate, 0.1% sodium fluoride, 0.1% tetrasodium pyrophosphate, surplus is deionized water, mix, obtain collutory by stirring.
Embodiment 8:
A kind of method that contains the collutory of Radix Notoginseng extract, formed by following component by weight percentage: 25% sorbitol, 10% glycerol, 1.2% tween 80,0.5% Tween-60,0.2% tetrasodium pyrophosphate, 0.05% sodium benzoate, 0.35% stem and leaf of Radix Notoginseng saponin, 0.7% green apple flavouring agent, 0.05% saccharin sodium, 0.15% sodium fluoride, surplus is deionized water, mix, obtain collutory by stirring.
Embodiment 9:
A kind of method that contains the collutory of Radix Notoginseng extract, formed by following component by weight percentage: 25% sorbitol, 10% propylene glycol, 1.2% alkyl polyglucoside, 0.15% tetrasodium pyrophosphate, 0.01% ethyl hydroxybenzoate, 1.5% flower of Radix Notoginseng saponin, 0.1% aspartame, 1% lemon flavor flavouring agent, 0.05% sodium fluoride, surplus is deionized water, mix, obtain collutory by stirring.
Embodiment 10:
A kind of method that contains the collutory of Radix Notoginseng extract, formed by following component by weight percentage: 20% glycerol, 15% xylitol, 1.2% alkyl polyglucoside, 0.2% tetrasodium pyrophosphate, 0.01% propylparaben, 0.5% flower of Radix Notoginseng saponin, 0.08% aspartame, 1% mint aroma flavouring agent, 0.1% sodium fluoride, surplus is deionized water, mix, obtain collutory by stirring.
Embodiment 11:
A kind of method that contains the collutory of Radix Notoginseng extract, formed by following component by weight percentage: xylitol 25%, propylene glycol 10%, 0.8% SDS, 0.2% tetrasodium pyrophosphate, butoben 0.01%, arasaponin 1.2%, 0.5% sucralose, 1% Herba Menthae Ilicis Purpureae flavouring agent, 0.1% sodium fluoride, surplus is deionized water, mix, obtain collutory by stirring.
Embodiment 12:
A kind of method that contains the collutory of Radix Notoginseng extract, formed by following component by weight percentage: 10% xylitol, 2% Sorbitol, 1% SDS, 0.1% tetrasodium pyrophosphate, 0.15% methyl hydroxybenzoate, 0.8% stem and leaf of Radix Notoginseng saponin, 0.01% saccharin sodium, 0.7% composite fragrant flavouring agent, 0.1% sodium fluoride, surplus is deionized water, mix, obtain collutory by stirring.
By following test:
Carry out clotting time of mice and the bleeding time test of mouse tail point with the arasaponin compatibility:
Animal: the ICR mice, unming Medical College experimental animal center provides.
Medicine and reagent: arasaponin 20mg is equivalent to the 0.250g crude drug, is produced by the applicant; YUNNAN BAIYAO 4g/ bottle, lot number 20101106, commercially available, YUNNAN BAIYAO limited company produces.
1. arasaponin clotting time of mice test: mice 18-22g, male and female half and half, be divided into 3 groups at random, every group 10, be normal saline group, YUNNAN BAIYAO group, arasaponin is with 27g crude drug 60kg people/order, and 18g/kg is equivalent to 40 times of people's consumption, YUNNAN BAIYAO 0.67g/kg, be equivalent to 40 times of people's consumptions, each animal groups is all irritated stomach with the 0.2ml/10g body weight, once/day, successive administration 5 days, give 30min in last, pluck a branch hole ball rapidly with curved tweezer, each one is bled at the microscope slide two ends, the about 5mm of blood diameter, timing at once.Provoke gently once inwards from the drop of blood edge with the cleaning pin every 30s, observing has depletion of blood.Begin to be clotting time to provoking required time till the blood streak from blood sampling.Another is bled and reviews result such as table 1 for last:
Table 1 arasaponin is to the influence (n=10, p＜0.05) of clotting time of mice
| ? | Normal saline | Arasaponin | YUNNAN BAIYAO |
| Dosage (g/kg) | Equal-volume | 18 | 0.67 |
| Clotting time (min) | 3.2 +0.8 | 2.27 +0.6 | 2.12 +0.6 |
The result shows that the YUNNAN BAIYAO of 18g/kg arasaponin and 0.67g/kg is there was no significant difference (p＜0.05) relatively, can obviously shorten clotting time of mice.
2. arasaponin mouse tail point bleeding time test: ICR mice 18-22g, male and female half and half are divided into 10 every group, be normal saline group, arasaponin group, YUNNAN BAIYAO group, arasaponin is 27g crude drug 60kg people/order, and 18g/kg is equivalent to 40 times of people's consumption, YUNNAN BAIYAO 0.67g/kg, be equivalent to 40 times of people's consumptions, each animal groups is all irritated stomach with the 0.2ml/10g body weight, once/day, successive administration 5 days, give 30min in last, apart from tail point 0.5cm place's crosscut.Every 30s dabs the tail point once with filter paper, does not see that from cross-section tail point to filter paper the bloodstain time is the mouse tail point bleeding time.Result such as table 2:
Table 2 Radix Notoginseng fluid extract is to the mouse tail influence (n=10, p＜0.05) in point bleeding time
| ? | Normal saline | Arasaponin | YUNNAN BAIYAO |
| Dosage (g/kg) | Equal-volume | 18 | 0.67 |
| Clotting time (min) | 15.2 +2.1 | 12.5 +1.6 | 9.2 +2.5 |
The result shows that 18g/kg Radix Notoginseng fluid extract shortens mouse tail point place's blood time, but is weaker than the YUNNAN BAIYAO of 0.679/kg.
Without departing from the present invention, can also carry out various conversion and be equal to replacement patent of the present invention, therefore, patent of the present invention is not limited to disclosed specific implementation process, and should comprise the whole embodiments that fall in the Patent right requirement scope of the present invention.
Claims (10)
1. collutory that contains Radix Notoginseng extract, it is characterized in that, be made up of following component by weight percentage: Radix Notoginseng extract 0.1%～1.5%, wetting agent 12%～35%, surfactant 0.8%～2.5%, sweeting agent 0.01%～0.5%, flavouring agent 0.5%～1%, antiseptic 0.01 ~ 0.15%, tetrasodium pyrophosphate 0.1 ~ 0.2%, sodium fluoride 0.05 ~ 0.15% surplus are deionized water.
2. a kind of collutory that contains Radix Notoginseng extract according to claim 1 is characterized in that, described Radix Notoginseng extract is one or more in arasaponin, stem and leaf of Radix Notoginseng saponin, the flower of Radix Notoginseng glycosides; Wetting agent is one or more in sorbitol, glycerol, propylene glycol, the xylitol; Surfactant is one or more among alkyl polyglucoside, sodium lauryl sulphate, tween 80, Tween-60, the castor oil hydrogenated RH-40; Sweeting agent is one or more in saccharin sodium, aspartame, the sucralose; Antiseptic is one or more in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben, the sodium benzoate.
3. a kind of collutory that contains Radix Notoginseng extract according to claim 1 is characterized in that, described flavouring agent is one or more in Herba Menthae Ilicis Purpureae odor type, mint aroma, lemon flavor, green apple odor type, the composite fruit odor type.
4. prepare the described a kind of method that contains the collutory of Radix Notoginseng extract of claim 1, it is characterized in that, press significant percentage with Radix Notoginseng extract 0.1%～1.5%, wetting agent 12%～35%, surfactant 0.8%～2.5%, sweeting agent 0.1%～0.5%, flavouring agent 0.5%～1%, antiseptic 0.01 ~ 0.15%, tetrasodium pyrophosphate 0.1 ~ 0.2%, sodium fluoride 0.05 ~ 0.15% surplus are deionized water, mix, obtain collutory by stirring.
5. a kind of method that contains the collutory of Radix Notoginseng extract according to claim 4 is characterized in that, described Radix Notoginseng extract is one or more in arasaponin, stem and leaf of Radix Notoginseng saponin or the flower of Radix Notoginseng glycosides.
6. a kind of method that contains the collutory of Radix Notoginseng extract according to claim 4 is characterized in that, described wetting agent is one or more in sorbitol, glycerol, propylene glycol, the xylitol.
7. a kind of method that contains the collutory of Radix Notoginseng extract according to claim 4 is characterized in that, described surfactant is one or more among alkyl polyglucoside, sodium lauryl sulphate, tween 80, Tween-60, the castor oil hydrogenated RH-40.
8. a kind of method that contains the collutory of Radix Notoginseng extract according to claim 4 is characterized in that, described sweeting agent is one or more in saccharin sodium, aspartame, the sucralose.
9. a kind of method that contains the collutory of Radix Notoginseng extract according to claim 4 is characterized in that, described flavouring agent is one or more in Herba Menthae Ilicis Purpureae odor type, mint aroma, lemon flavor, green apple odor type, the composite fruit odor type.
10. a kind of method that contains the collutory of Radix Notoginseng extract according to claim 4 is characterized in that, described antiseptic is one or more in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben, the sodium benzoate.
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