CN106265114A - A kind of for collutory alleviating periodontitis and preparation method thereof - Google Patents
A kind of for collutory alleviating periodontitis and preparation method thereof Download PDFInfo
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- CN106265114A CN106265114A CN201610783491.0A CN201610783491A CN106265114A CN 106265114 A CN106265114 A CN 106265114A CN 201610783491 A CN201610783491 A CN 201610783491A CN 106265114 A CN106265114 A CN 106265114A
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- Prior art keywords
- collutory
- beta
- schardinger dextrin
- periodontitis
- alleviating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a kind of for collutory alleviating periodontitis and preparation method thereof, and this collutory is effective anti-inflammation components with berberine hydrochloride.Concrete, this collutory includes the raw material of following mass ratio: anti-inflammation components 0.5%～5%, sweeting agent 0.01%～2%, aromatic 0.01%～2%, wetting agent 1%～10%, preservative 0.1%～2%, surplus is deionized water.Wherein, anti-inflammation components uses beta cyclodextrin inclusion berberine hydrochloride, and clathrate can improve dissolubility and the stability of berberine hydrochloride, and the most removable bitterness, improves its mouthfeel simultaneously.The collutory of the present invention can pre-preventing parodontitis, alleviate periodontitis, and can long-acting holding oral cavity fresh and cool.
Description
Technical field
The invention belongs to oral cleaning nursing article technical field, be specifically related to a kind of collutory for alleviating periodontitis
And preparation method thereof.
Background technology
Periodontitis is as a kind of common oral disease, and for the chronic inflammatory disease of periodontal tissue, pathological process can involve gingiva,
Alveolar bone, periodontal membrane and cementum, cause odontoseisis, ultimately causes loss of tooth, brings great misery to patient.Gargle
Water is as a kind of method in cleaning oral cavity easily and fast, currently used more and more extensive, periodontitis can be carried out auxiliary and control
Treat.Collutory can make up toothpaste and carries and awkward shortcoming simultaneously, and oral cavity can be cleaned nursing whenever and wherever possible,
Fresh breath, prevents oral disease, alleviates periodontitis.
Prior art has and uses Chinese medicine extract to treat periodontitis as collutory, but processing technique can be caused multiple
Miscellaneous, cost increases.Berberine hydrochloride is confirmed by those skilled in the art as the safety of collutory raw material, and hydrochloric acid is little
Bark of a cork tree alkali is a kind of active substance extracted in plant, has the multiple efficacies such as antiinflammatory, analgesia, heat-clearing and toxic substances removing, has many clinically
Plant curative effect.Berberine hydrochloride, by the regulation to Inflammatory Pathway, can effectively be alleviated periodontitis, but berberine hydrochloride is insoluble in
Water, and bitter in the mouth, with being directly used in, collutory then mouthfeel is bad.
Summary of the invention
For above-mentioned deficiency of the prior art, the invention provides a kind of is effective anti-inflammation components with berberine hydrochloride
Collutory, can pre-preventing parodontitis, alleviate periodontitis, improve mouthfeel and can long-acting holding oral cavity fresh and cool.
A kind of collutory for alleviating periodontitis is provided one of for achieving the above object, present invention employs techniques below
Scheme:
A kind of collutory for alleviating periodontitis, this collutory includes the raw material of following mass fraction:
Preferably, this collutory includes the raw material of following mass fraction:
Further, described anti-inflammation components is beta-schardinger dextrin-berberine hydrochloride clathrate.
Further, described beta-schardinger dextrin-berberine hydrochloride clathrate, including the raw material of following mass fraction:
Beta-schardinger dextrin-2%～5%；
Berberine hydrochloride 1%～8%；
Surplus is deionized water.
Further, the preparation method of described beta-schardinger dextrin-berberine hydrochloride clathrate, comprise the steps:
In S1, deionized water under uniform temperature, add beta-schardinger dextrin-, at the uniform velocity stir 30min, obtain beta-schardinger dextrin-and satisfy
And aqueous solution；
S2, in beta-schardinger dextrin-saturated aqueous solution, it is added dropwise over berberine hydrochloride alcoholic solution；
S3, at a certain temperature, at the uniform velocity stirring carry out inclusion；
S4, putting at room temperature, standing 24h must precipitate；
S5, filtration precipitation, be dried, obtain beta-schardinger dextrin-berberine hydrochloride clathrate.
Further, in described beta-schardinger dextrin-berberine hydrochloride clathrate preparation process S1 and S3, preparation temperature is 30 DEG C
～50 DEG C.
Further, in described beta-schardinger dextrin-berberine hydrochloride clathrate preparation process S3, inclusion mixing time is 30min
～3h.
Preferably, described sweeting agent is xylitol, saccharin sodium, one or more in cyclamate；Described aromatic is thin
Lotus essence, honeysuckle compound, one or more in Green tea essence；Described wetting agent is glycerol, sorbitol, in mannitol
Plant or several.
Preferably, described preservative is potassium sorbate.
Present invention also offers the preparation method of a kind of collutory for alleviating periodontitis, in terms of mass fraction, including
Following steps:
S1, in a certain amount of deionized water, add 0.5%～5% beta-schardinger dextrin-berberine hydrochloride clathrate；
S2, stirring, to being completely dissolved, add the sweeting agent of 0.01%～2%；
S3, stirring, to being completely dissolved, add the aromatic of 0.01%～2%；
S4, stirring, to being completely dissolved, add the wetting agent of 1%～10%；
S5, stirring, to being completely dissolved, add the preservative of 0.1%～2%；
S6, completion deionized water, fill, must have the collutory alleviating periodontitis function.
The beneficial effects of the present invention is:
1), the present invention be main anti-inflammation components with berberine hydrochloride, by suppression Inflammatory Pathway, reduce inflammatory factor table
Reaching, and then alleviate oral cavity periodontitis, meanwhile, the present invention carries out inclusion with beta-schardinger dextrin-to berberine hydrochloride, has both added hydrochloric acid
The dissolubility of berberine, also reduces the bitterness of berberine hydrochloride, improves its mouthfeel.
2), the raw material used by the present invention is all food stage, to health non-hazardous after swallowing.
3), the present invention with plant essence as aromatic, can long-acting fresh breath.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the present invention is clearly and completely described.Following reality
Execute example and be only used for clearly illustrating technical scheme, and can not limit the scope of the invention with this.
A kind of collutory for alleviating periodontitis
This collutory includes the raw material of following mass fraction:
As one preferred embodiment, this collutory includes the raw material of following mass fraction:
Wherein, described anti-inflammation components is beta-schardinger dextrin-berberine hydrochloride clathrate.Described sweeting agent is xylitol, saccharin
Sodium, one or more in cyclamate.Described aromatic is Mint Essence, honeysuckle compound, the one or several in Green tea essence
Kind.Described wetting agent is glycerol, sorbitol, one or more in mannitol.Described preservative is potassium sorbate.
Concrete, described beta-schardinger dextrin-berberine hydrochloride clathrate, including the raw material of following mass fraction:
Beta-schardinger dextrin-2%～5%；
Berberine hydrochloride 1%～8%；
Surplus is deionized water.
Wherein, the preparation method of described beta-schardinger dextrin-berberine hydrochloride clathrate, comprise the steps:
S1, in the deionized water of 30 DEG C～50 DEG C, add beta-schardinger dextrin-, at the uniform velocity stir 30min, obtain beta-schardinger dextrin-satisfy
And aqueous solution；
S2, in beta-schardinger dextrin-saturated aqueous solution, it is added dropwise over berberine hydrochloride alcoholic solution；
S3, at 30 DEG C～50 DEG C, at the uniform velocity stirring 30min～3h carry out inclusion；
S4, putting at room temperature, standing 24h must precipitate；
S5, filtration precipitation, be dried, obtain beta-schardinger dextrin-berberine hydrochloride clathrate.
A kind of preparation method of the collutory for alleviating periodontitis
In terms of mass fraction, comprise the steps:
S1, in a certain amount of deionized water, add 0.5%～5% beta-schardinger dextrin-berberine hydrochloride clathrate；
S2, stirring, to being completely dissolved, add the sweeting agent of 0.01%～2%；
S3, stirring, to being completely dissolved, add the aromatic of 0.01%～2%；
S4, stirring, to being completely dissolved, add the wetting agent of 1%～10%；
S5, stirring, to being completely dissolved, add the preservative of 0.1%～2%；
S6, completion deionized water, fill, must have the collutory alleviating periodontitis function.
Embodiment 1
One, beta-schardinger dextrin-berberine hydrochloride clathrate, prepares in the following manner:
S1, take 92ml ionized water, be heated to 50 DEG C, add beta-schardinger dextrin-3g；At the uniform velocity stir 30min, obtain beta-schardinger dextrin-
Saturated aqueous solution；
S2, in beta-schardinger dextrin-saturated aqueous solution, it is added dropwise over berberine hydrochloride alcoholic solution 5g；
S3, at 50 DEG C, at the uniform velocity stirring 2h carry out inclusion；
S4, stopping heating, standing 24h must precipitate；
S5, filtration precipitation, be dried, obtain beta-schardinger dextrin-berberine hydrochloride clathrate；
Two, the beta-schardinger dextrin-berberine hydrochloride clathrate using above-mentioned preparation makees anti-inflammation components, for alleviating periodontitis
Collutory includes the raw material of following content:
Three, the preparation method of the above-mentioned collutory for alleviating periodontitis, comprises the steps:
S1, in 50g deionized water, add 3g beta-schardinger dextrin-berberine hydrochloride clathrate；
S2, stirring, to being completely dissolved, add the sweeting agent saccharin sodium of 0.1g；
S3, stirring, to being completely dissolved, add the aromatic Green tea essence of 0.1g；
S4, stirring, to being completely dissolved, add the wetting agent glycerol of 5g；
S5, stirring, to being completely dissolved, add the potassium sorbate preservative of 0.5g；
S6, completion deionized water 41.3g, fill, must have the collutory alleviating periodontitis function.
Embodiment 2
One, beta-schardinger dextrin-berberine hydrochloride clathrate, prepares in the following manner:
S1, take 97ml deionized water, be heated to 30 DEG C, add beta-schardinger dextrin-2g；At the uniform velocity stir 30min, obtain β-ring and stick with paste
Essence saturated aqueous solution；
S2, in beta-schardinger dextrin-saturated aqueous solution, it is added dropwise over berberine hydrochloride alcoholic solution 1g；
S3, at 30 DEG C, at the uniform velocity stirring 3h carry out inclusion；
S4, stopping heating, standing 24h must precipitate；
S5, filtration precipitation, be dried, obtain beta-schardinger dextrin-berberine hydrochloride clathrate.
Two, the beta-schardinger dextrin-berberine hydrochloride clathrate using above-mentioned preparation makees anti-inflammation components, for alleviating periodontitis
Collutory includes the raw material of following content:
Three, the preparation method of the above-mentioned collutory for alleviating periodontitis, comprises the steps:
S1, in 50g deionized water, add 4g beta-schardinger dextrin-berberine hydrochloride clathrate；
S2, stirring, to being completely dissolved, add the sweeting agent xylitol of 0.3g；
S3, stirring, to being completely dissolved, add the aromatic Mint Essence of 0.2g；
S4, stirring, to being completely dissolved, add the wetting agent sorbitol of 3g；
S5, stirring, to being completely dissolved, add the potassium sorbate preservative of 0.6g；
S6, completion deionized water 41.9g, fill, must have the collutory alleviating periodontitis function.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, on the premise of without departing from the technology of the present invention principle, it is also possible to make some improvement and deformation, these improve and deformation
Also should be regarded as protection scope of the present invention.
Claims (10)
1. one kind for alleviating the collutory of periodontitis, it is characterised in that this collutory includes the raw material of following mass fraction:
A kind of collutory for alleviating periodontitis the most according to claim 1, it is characterised in that this collutory include with
The raw material of lower mass fraction:
A kind of collutory for alleviating periodontitis the most according to claim 1 and 2, it is characterised in that: described antiinflammatory becomes
It is divided into beta-schardinger dextrin-berberine hydrochloride clathrate.
A kind of collutory for alleviating periodontitis the most according to claim 3, it is characterised in that described beta-schardinger dextrin-salt
Acid berberine clathrate, including the raw material of following mass fraction:
Beta-schardinger dextrin-2%～5%；
Berberine hydrochloride 1%～8%；
Surplus is deionized water.
A kind of collutory for alleviating periodontitis the most according to claim 4, it is characterised in that described beta-schardinger dextrin-salt
The preparation method of acid berberine clathrate, comprises the steps:
In S1, deionized water under uniform temperature, add beta-schardinger dextrin-, at the uniform velocity stir 30min, obtain beta-schardinger dextrin-saturation water
Solution；
S2, in beta-schardinger dextrin-saturated aqueous solution, it is added dropwise over berberine hydrochloride alcoholic solution；
S3, at a certain temperature, at the uniform velocity stirring carry out inclusion；
S4, putting at room temperature, standing 24h must precipitate；
S5, filtration precipitation, be dried, obtain beta-schardinger dextrin-berberine hydrochloride clathrate.
A kind of collutory for alleviating periodontitis the most according to claim 5, it is characterised in that: described beta-schardinger dextrin-salt
In acid berberine clathrate preparation process S1 and S3, preparation temperature is 30 DEG C～50 DEG C.
A kind of collutory for alleviating periodontitis the most according to claim 6, it is characterised in that: described beta-schardinger dextrin-salt
In acid berberine clathrate preparation process S3, inclusion mixing time is 30min～3h.
A kind of collutory for alleviating periodontitis the most according to claim 1, it is characterised in that: described sweeting agent is wood
Sugar alcohol, saccharin sodium, one or more in cyclamate；Described aromatic is Mint Essence, and honeysuckle compound, in Green tea essence
One or more；Described wetting agent is glycerol, sorbitol, one or more in mannitol.
A kind of collutory for alleviating periodontitis the most according to claim 1, it is characterised in that: described preservative is mountain
Potassium sorbate.
10. the preparation method being used for alleviating the collutory of periodontitis, it is characterised in that in terms of mass fraction, including as follows
Step:
S1, in a certain amount of deionized water, add 0.5%～5% beta-schardinger dextrin-berberine hydrochloride clathrate；
S2, stirring, to being completely dissolved, add the sweeting agent of 0.01%～2%；
S3, stirring, to being completely dissolved, add the aromatic of 0.01%～2%；
S4, stirring, to being completely dissolved, add the wetting agent of 1%～10%；
S5, stirring, to being completely dissolved, add the preservative of 0.1%～2%；
S6, completion deionized water, fill, must have the collutory alleviating periodontitis function.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610783491.0A CN106265114A (en) | 2016-08-30 | 2016-08-30 | A kind of for collutory alleviating periodontitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610783491.0A CN106265114A (en) | 2016-08-30 | 2016-08-30 | A kind of for collutory alleviating periodontitis and preparation method thereof |
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| CN106265114A true CN106265114A (en) | 2017-01-04 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107320380A (en) * | 2017-07-26 | 2017-11-07 | 何家平 | A kind of new Chinese herbal medicine toothwash hydraulic art |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054717A (en) * | 1989-03-06 | 1991-09-25 | 黑龙江中医学院 | Cleaning agent for mouth cavity (or toothpaste) and manufacture method |
| CN101249056A (en) * | 2008-01-11 | 2008-08-27 | 美晨集团股份有限公司 | Anti-inflammation gargle water and method of preparing the same |
| CN101461949A (en) * | 2009-01-09 | 2009-06-24 | 天津中医药大学 | Berberine cyclodextrin inclusion compound, preparation thereof and preparation method |
| CN103263375A (en) * | 2013-05-30 | 2013-08-28 | 云南七丹药业股份有限公司 | Mouthrinse containing extract and preparation method of mouthrinse |
-
2016
- 2016-08-30 CN CN201610783491.0A patent/CN106265114A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054717A (en) * | 1989-03-06 | 1991-09-25 | 黑龙江中医学院 | Cleaning agent for mouth cavity (or toothpaste) and manufacture method |
| CN101249056A (en) * | 2008-01-11 | 2008-08-27 | 美晨集团股份有限公司 | Anti-inflammation gargle water and method of preparing the same |
| CN101461949A (en) * | 2009-01-09 | 2009-06-24 | 天津中医药大学 | Berberine cyclodextrin inclusion compound, preparation thereof and preparation method |
| CN103263375A (en) * | 2013-05-30 | 2013-08-28 | 云南七丹药业股份有限公司 | Mouthrinse containing extract and preparation method of mouthrinse |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107320380A (en) * | 2017-07-26 | 2017-11-07 | 何家平 | A kind of new Chinese herbal medicine toothwash hydraulic art |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170104 |
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| RJ01 | Rejection of invention patent application after publication |