KR20190057727A - Composition for improving bronchial health improved palatability - Google Patents

Abstract

The present invention relates to a jelly composition for improving bronchial health with improved palatability. Specifically, the jelly composition for improving bronchial health with improved palatability according to the present invention is characterized in that a bitter taste unique to natural herbal ingredients and antipyretic analgesic cold medicine is masked and children, elderly people, and the like can easily ingest the same due to significantly increased palatability. Therefore, it is possible to easily and conveniently ingest various beneficial ingredients for bronchial improvement.

Description

Technical Field [0001] The present invention relates to a bronchial health pharmacological composition having improved palatability,

The present invention relates to a composition for improving bronchial health and a method for producing the same, wherein a specific bitterness is removed and palatability is remarkably improved.

Modern people are exposed to allergic bronchial diseases caused by air pollution, allergy sources (animal hair, pollen, etc.) and smoking due to the development of industry and diseases such as colds, bronchitis, tuberculosis, pneumonia, chronic bronchitis, Is known to be one of the most frequently occurring diseases.

A cold is a sudden occurrence of runny nose and blockage in all age groups. Bronchitis is an infectious disease caused by infections of tubercle bacilli. It is an inflammatory disease that occurs in lung tissue. Chronic bronchitis is an inflammation of the bronchial bronchus, which causes the bronchial mucosa to become narrowed by fibrous inflammatory reaction, and the mucous secretion from mucosal cells increases and the airway obstructs.

Sputum is mostly white, slightly yellowish, mucinous and tends to come out in the morning. When the disease progresses, the respiratory difficulty gradually increases over a period of several months to several years, so that even a little activity causes difficulty in breathing. The causes are allergic, infectious, and traumatic. Pathologically, they are catarrhal, purulent, ulcerative, and invasive. The most common cause is infection by bacteria, viruses, and fungi, and people who are not infected usually tend to become infected when the resistance of the whole body is weakened.

On the other hand, in order to improve the bronchial health, it is used for the treatment of the above-mentioned diseases by taking various kinds of herbal materials including acacia, licorice, and loser, and acetaminophen which is a typical cold medicine. However, due to its bitter taste, There is a need to develop a formulation which can be easily taken, ingested and extinguished by children and the like.

Generally, jelly is a semi-solid saccharide food having excellent storage stability prepared by using various gums such as gelatin, agar, carrageenan, pectin and the like.

In order to produce a jelly-like food, there should be no suspended solid particles and a certain amount of sugar content and juice. Usually, the jelly is concentrated so that the soluble solid component is more than a certain amount. The flavor and the coloring substance are added so that the optimum concentration of the gelling sugar is 0.5-5.0 wt%, the acidity is 3-5 and the sugar concentration is 20-85% do.

Jelly has been widely consumed as a general food having various flavors and flavors as a favorite food for children and a dessert food for a long time, but in recent years, a jelly product has been developed by using various food materials. .

For example, Korean Patent Registration No. 10-0649693 discloses a method for producing jelly, which comprises the steps of dissolving agar in purified water to obtain an agar solution, adding a sub ingredient to the agar solution, heating to gelify, And adding the nutrient concentrate to the agar solution, which contains the nutrient solution, and heating the agar jelly.

Korean Patent Laid-Open No. 10-2010-0034528 discloses a herbal medicine jelly using a herbal medicine and a method for producing the herb medicine, wherein the herbal medicine ingredient is selected from the group consisting of jelly, safflower and persimmon, and gelling ingredients, sweetener, natural antibacterial agent, Discloses a herbal medicine jelly made from jelly.

Korean Patent Laid-Open Publication No. 10-2003-0072282 discloses a seaweed jelly prepared by adding agaric acid, citric acid, and sugar to a seaweed containing a large amount of alginic acid, i.e., seaweed extract, in the method of producing kelp jelly by adding seaweed extract The dried kelp was dried and pulverized, and then 13 times the weight of water was added. The resulting mixture was extracted at 50 ° C for 2 hours, and the supernatant was concentrated under reduced pressure to 5 Brix. The resulting kelp concentrate was added with pectin and citric acid, And the resulting mixture is heated and concentrated until the sugar content reaches 65 to 70 Brix, followed by cooling the mixture to prepare kelp jelly.

On the other hand, when the jelly formulation is manufactured, the raw ingredient used in the jelly formulation may be unpleasant and unpleasant, such as tasting the food itself, tingling, tearing, squeezing, etc., Therefore, it is necessary to study the composition and the compounding ratio which can mask such a bitter taste and increase the palatability, because there is a limit in manufacturing a jelly formulation when using a raw ingredient showing a bitter taste.

Accordingly, the present inventors have made efforts to develop a formulation for improving the bitter taste of natural oriental herbal ingredients and antipyretic analgesic medicines, which are useful for bronchial health. As a result, the inventors of the present invention have found that when a gelatin preparation and a gelling agent , Natural oriental herbal ingredients and antipyretic analgesic herbicides are masked, and the palatability is markedly increased. Thus, the jelly composition using the constitution and the composition ratio established in the present invention is a composition which can be easily ingested by children, elderly people, etc. The present invention has been completed.

It is an object of the present invention to provide a jelly composition for improving bronchial health, in which the bitter taste unique to the conventional bronchial health improving agent is removed and the palatability is remarkably improved.

In order to achieve the above object, the present invention provides a jelly composition comprising a plant extract for improving bronchial health, an antipyretic analgesic, or a combination thereof,

1.0 to 2.0 parts by weight of a plant extract for improving bronchial health, an antipyretic analgesic, or a combination thereof;

1.0 to 1.4 parts by weight of carrageenan, xanthan gum and locust bean gum as gelling agents; And

And 10 to 14 parts by weight of an inclusion-free cyclodextrin. The present invention also provides a jelly composition for improving bronchial health.

The jelly composition for improving bronchial health having improved palatability of the present invention can be easily ingested by children and elderly people because the bitter taste unique to natural oriental herbal ingredients or antipyretic analgesic herb is shielded and the preference is remarkably increased, And has an advantage that the useful ingredient can be easily and easily ingested.

Hereinafter, the present invention will be described in detail.

The present invention relates to a jelly composition comprising a plant extract for improving bronchial health, an antipyretic analgesic, or a combination thereof,

1.0 to 2.0 parts by weight of a plant extract for improving bronchial health, an antipyretic analgesic, or a combination thereof;

1.0 to 1.4 parts by weight of carrageenan, xanthan gum and locust bean gum as gelling agents; And

And 10 to 14 parts by weight of an inclusion-free cyclodextrin. The present invention also provides a jelly composition for improving bronchial health.

The plant extract for improving bronchial health may be any of various known plant extracts having a bronchodilating activity within the scope of the present invention. Specific examples of the botanical extracts include bacillus, licorice, lycopersicum, cinnamon, bellflower, dandelion, , Ulgum, Maekmundong, Chunggi, Golden or Red ginseng extracts can be used alone or in combination.

In addition, the plant extract is preferably, but not exclusively, prepared by a method comprising the steps of:

1) Extracting the extracts by adding an extraction solvent to the extracts of licorice, licorice, lycoris, cinnamon, bellflower, dandelion, corn,

2) filtering the extract of step 1);

3) concentrating the filtrate of step 2) under reduced pressure; And

4) drying the concentrate of step 3).

In the production method of the present invention, it is possible to use, without limitation, those cultivated or marketed in the step 1), licorice, licorice, lemonade, cinnamon, bellflower, dandelion, .

In the production method of the present invention, it is preferable to use water, an alcohol or a mixture thereof as the extraction solvent in the step 1). As the alcohol, C ₁ to C ₂ lower alcohols are preferably used, and as the lower alcohol, ethanol or methanol is preferably used. As the extraction method, it is preferable to use shaking extraction, Soxhelt extraction or reflux extraction, but not limited thereto. The extraction solvent is preferably added by 1 to 10 times the amount of the dried active plant, more preferably by 2 to 3 times. The extraction temperature is preferably 20 ° C to 100 ° C, and most preferably 20 ° C to 50 ° C, but is not limited thereto. The extraction time is preferably 1 to 48 hours, more preferably 2 to 10 hours, most preferably 2 to 5 hours, but is not limited thereto. The number of times of extraction is preferably 1 to 5 times, more preferably 3 to 4 times, more preferably 3 times, but is not limited thereto.

In the production method of the present invention, it is preferable to use a vacuum decompression concentrator or a vacuum rotary evaporator for the decompression concentration in step 3), but it is not limited thereto. The drying is preferably performed under reduced pressure, vacuum drying, boiling, spray drying or freeze drying, but not always limited thereto.

The antipyretic analgesic may be any of various known antipyretic analgesics and is preferably selected from the group consisting of acetylsalicylic acid, acetaminophen, ibuprofen, and dexibuprofen. Any one, or any one or more of them may be mixed and used.

In addition, the plant extract for improving bronchial health, the antipyretic analgesic, or a combination thereof is preferably contained in an amount of 1.0 to 2.0 parts by weight based on the total weight of the jelly composition.

The gelling agent may be a mixture of carrageenan, xanthan gum and locust bean gum. In order to prepare the jelly composition of the present invention having improved palatability, the gelling agent may be a mixture of jelly 0.4 to 0.6 parts by weight of carrageenan, 0.2 to 0.4 parts by weight of xanthan gum and 0.3 to 0.5 parts by weight of locust bean gum are contained in the total amount of the jelly composition in the range of 1.0 to 1.4 parts by weight based on the total weight of the composition, Most preferably, 0.5 part by weight of carrageenan, 0.3 part by weight of xanthan gum and 0.4 part by weight of locust bean gum should be added to the total weight of the jelly composition. If the proportion of the jelly composition exceeds the ratio established in the present invention, the hardness, , Chewiness and overall acceptability were significantly deteriorated, and the ease of ingestion was remarkably decreased. On the other hand, Since the cause of the bitter taste that allows you to feel better, it can not achieve the object of the present invention.

In order to enhance sensory properties, the saccharide, fruit juice, juice extract, organic acid and the like may be used. However, in order to mask the bitter taste of the present invention, cyclodextrin is preferably added in a total amount of 11 To 13 parts by weight of the total amount of the jelly composition. If the mixing ratio established in the present invention is exceeded, the bitter taste of the present invention can not be masked, resulting in marked deterioration of the functionality. , And 11 to 13 parts by weight.

Further, in the case of the jelly composition of the present invention, the amount of the plant extract for improving bronchial health or the amount of the antipyretic analgesic agent established in the present invention; The addition amount of carrageenan, xanthan gum and locust bean gum as a gelling agent; When only the amount of the inclusion-free cyclodextrin is the same as that of the present invention, the jellied composition may be prepared using any process or various additives, all of which are included in the present invention.

The jelly composition of the present invention may be prepared by using the blending ratio established in the present invention, but is not limited thereto:

1) preparing plant extracts for improving bronchial health;

2) mixing cyclodextrin and purified water with the plant extract of step 1), and then stirring to prepare a solution;

3) mixing the additive in the solution of the step 2);

4) dewatering the sugar and the gelling agent and calcium lactate;

5) mixing the gelling agent mixture prepared in the step 4) with the mixture solution containing the additive of the step 3), and then stirring.

The plant extract for improving bronchial health of the step 1) may be used alone or in combination with various plants having bronchopulmonary health improving activity, and an antipyretic analgesic may be used instead of the plant extract.

The plant extract of step 2) may be contained in an amount of 1.0 to 2.0 parts by weight based on the total weight of the jelly composition, 10 to 14 parts by weight of the cyclodextrin, 1.0 to 1.4 parts by weight of carrageenan, xanthan gum and locust bean gum . The purified water may be edible water, and it is preferably 50 to 60 parts by weight, and preferably 55 to 58 parts by weight based on the total weight of the jelly composition.

In addition, the additive of step 3) may be various additives added to the jelly composition, but it is preferable to use fruit concentrate, agave syrup, sucralose, anhydrous citric acid and herbal extracts But is not limited thereto.

After the step 5), a step of defoaming for 10 to 15 minutes and then sterilizing for 30 minutes to ensure stability can be added.

Meanwhile, in a specific embodiment of the present invention, the inventors of the present invention prepared a jelly composition using a botanical extract for improving bronchial health and acetaminophen as an antipyretic analgesic, and then, in order to search for an optimum compounding ratio excellent in taste and texture, It was found that the addition of 0.5% by weight of carrageenan, 0.3% by weight of xanthan gum and 0.4% by weight of locust bean gum to the gelling composition in the preparation of the jelly composition resulted in an optimum composition and mixing ratio (See Table 2 and Table 3).

In addition, the present inventors confirmed that the optimum blending ratio of the whitening agent for masking the bitter taste by using the mixed plant extract for enhancing bronchial health is as follows. In the production of the jelly composition, the addition of 11 to 13 wt.% Of cyclodextrin as the inclusion agent promotes palatability (See Table 5). ≪ tb > < TABLE >

Accordingly, the jelly composition for improving bronchial health having improved palatability of the present invention can be easily ingested by children, elderly people, and the like because the bitter taste unique to natural herbal ingredients and antipyretic analgesic cold medicine is shielded and the preference is remarkably increased. It is possible to easily and conveniently ingest various useful ingredients for the active ingredient.

Hereinafter, the present invention will be described in detail with reference to Examples and Experimental Examples.

However, the following examples and experimental examples are merely illustrative of the present invention, and the content of the present invention is not limited to the following examples and experimental examples.

< Example  1> Manufacture of plant extracts for bronchial health promotion

Plant extracts for the improvement of bronchial health were prepared by extracting ethanol, licorice, lycopersicum, cinnamon, bellflower, dandelion,

Specifically, 10 kg of the sample was washed and dried and charged into an extraction tank. 80% ethanol was added at 5 to 7 times the weight of the mixture, and the mixture was refluxed and cooled at 60 ° C for 4 hours. In the extraction process, the extract was filtered with paper filter paper, and 80% ethanol was added to the filtrate. The extract was extracted at 60 ° C for 4 hours, and the extract was filtered using paper filter paper. The filtrate was concentrated under reduced pressure at 50 DEG C or lower to prepare a plant extract for improving bronchial health.

< Example  2> Preparation of jelly formulations with enhanced palatability

&Lt; 2-1 > Preparation of a jelly composition containing a plant mixed extract

A jelly composition containing the plant extract of Example 1 was prepared.

Specifically, to remove the bitter taste of 1.0 g of the plant extract prepared in Example 1, 12.0 g of cyclodextrin as an inclusion agent and 57.35 g of purified water were mixed and stirred for 30 minutes at 65 ° C to completely remove the bitter taste. 8 g of fruit concentrate, 10 g of agave syrup, 0.2 g of sucralose, 0.12 g of anhydrous citric acid and 0.03 g of herbal extract were added to the mixture, and the mixture was stirred for 10 minutes. Separately, 10 g of sugar and 1.2 g of a gelling agent (carrageenan, xanthan gum and locust bean gum) and 0.1 g of calcium lactate were preliminarily blended so as not to clump together. This is to maintain uniform particle distribution during jelly formation during the manufacturing process. Calcium lactate is added because it strengthens the structure during gel formation and it is involved in hardness of jelly. After the mixture was heated to 85 ° C, the gelling agent mixture was gradually added to dissolve it completely. In order to remove air bubbles due to the characteristics of the gelling agent due to stirring at high temperature, it was degassed for about 10 to 15 minutes and then sterilized at 90 ° C. for 30 minutes to ensure stability.

&Lt; 2-2 > Production of jelly composition containing antipyretic analgesic drug

A jelly composition comprising acetaminophen, an antipyretic analgesic, was prepared.

Specifically, a jelly composition was prepared in the same manner as in Example <2-1>, except that 1.16 g of acetaminophen was used instead of 1.0 g of the plant extract prepared in Example 1 above.

&Lt; 2-2 > Preparation of a jelly composition including a plant mixed extract and an antipyretic analgesic cold agent

A jellied composition comprising the plant extract of Example 1 and acetaminophen as an antipyretic analgesic was prepared.

Specifically, a jelly composition was prepared in the same manner as in Example <2-1>, except that 0.5 g of the plant extract prepared in Example 1 and 0.58 g of acetaminophen were used.

< Experimental Example  1> Confirmation of optimum composition and mixing ratio of jelly formulations with improved palatability

<1-1> Gelling agent  Determine optimal ratio

In the present invention, the optimum composition and blending ratio of the gelling agent was confirmed in order to find an optimum blend ratio in the preparation of jelly compositions using plant mixed extracts for bronchial health promotion and antipyretic analgesic agent. In addition, the correlation between physical properties and sensory properties was optimized by the one - way ANOVA.

Specifically, a jelly formulation was prepared in the same manner as in Example <2-1>, and the composition and mixing ratio of the gelling agent were g as shown in Table 1 below to prepare a jelly formulation.

Then, the texture and sensuality of the jelly were sampled by 50 well-trained professional sensory test agents (20s, 10s, 30s, 10s, 50s, 10s, 60s, 10s) The properties were measured with a Rheometer and the conditions of plunger diameter 10mm, table speed 60mm / min, sample height 10mm and load cell 2kg were used and hardness, cohesiveness, springiness ) And chewiness were repeatedly measured three times and evaluated using the average value.

division Carrageenan (g) Xanthan gum (g) Locust bean gum (g) Experiment 1 0.5 0.3 0.4 Experiment 2 0.5 0.25 0.35 Experiment group 3 0.5 0.2 0.3 Experiment group 4 0.5 0.15 0.25 Experiment group 5 0.5 0.1 0.2 Experiment group 6 0.5 0.05 0.15 Experiment group 7 0.5 0.01 0.1

As a result, as shown in the following [Table 2] and [Table 3], there was no difference in color and flavor according to the ratio of the gelling agent, but when the jelly was produced in the weight ratio of <Experiment group 1> (Table 2 and Table 3). The results are shown in Table 2 and Table 3.

Therefore, it was confirmed that in the preparation of the jelly composition, 0.5% by weight of carrageenan, 0.3% by weight of xanthan gum and 0.4% by weight of locust bean gum were added to the jelly formulation to improve the palatability.

<1-2> Porcine  Determine optimal ratio

In the present invention, the optimal blending ratio of the whitening agent for masking the bitter taste was confirmed in the production of the jelly composition using the plant mixed extract for enhancing bronchial health.

Specifically, the plant-mixed extracts were evaluated by the pre-sensory evaluation, and it was confirmed that the plant-mixed extracts prepared in Example 1 had a strong bitter taste and markedly lowered the preference degree. Thus, the plant mixture prepared in Example 1 The extracts were used to confirm whether or not bitterness was masked.

The gelling agent used was 0.5% by weight of carrageenan, 0.3% by weight of xanthan gum and 0.4% by weight of locust bean gum, which were confirmed in the optimum compounding ratio in the above Experimental Example 1-1, and the cyclodextrin shown in [Table 4] A jelly composition was prepared in the same manner as in <Example 2>, except that each of the g's in Table 4 was used to prepare a jelly formulation.

In addition, texture and sensory evaluation of jelly were measured in the same manner as in Experimental Example 1-1.

As a result, as shown in the following Table 5, it was confirmed that when the cyclodextrin was added to the jellied composition in an amount of 11 to 13 wt% (11 to 13 g per 100 g), the bitter taste of the plant mixed extract was remarkably masked, , It was confirmed that the overall acceptability of the plant mixture extract was significantly lowered due to bitter taste (Table 5).

Therefore, it was confirmed that the addition of 11-13 wt% of cyclodextrin as an inclusion agent in the preparation of the jelly composition is an optimal blend ratio of the jelly formulation having improved palatability.

Claims (9)

A jelly composition comprising a plant extract for improving bronchial health,
1.0 to 2.0 parts by weight of plant extract for improving bronchial health;
1.0 to 1.4 parts by weight of carrageenan, xanthan gum and locust bean gum as gelling agents; And
10. The jelly composition for improving bronchial health according to claim 1, wherein the composition comprises 10 to 14 parts by weight of an inclusion-free cyclodextrin.
[3] The plant extract according to claim 1, wherein the plant extract for improving bronchial health comprises at least one selected from the group consisting of red ginseng root, licorice root, cinnamon, bellflower, dandelion, Wherein the jellied composition is used for improving bronchial health.
The jelly composition for improving bronchial health according to claim 1, further comprising an antipyretic analgesic agent in the plant extract for improving bronchial health.
4. The method of claim 3, wherein the antipyretic analgesic is any one selected from the group consisting of acetylsalicylic acid, acetaminophen, ibuprofen, and dexibuprofen. Wherein said jelly composition is used for improving bronchial health.
The bronchial health improvement according to claim 1, wherein the gelling agent is added in an amount of 0.4 to 0.6 parts by weight of carrageenan, 0.2 to 0.4 parts by weight of xanthan gum, and 0.3 to 0.5 parts by weight of locust bean gum, Jelly composition.
2. The jelly composition for improving bronchial health according to claim 1, wherein the gelling agent is added in an amount of 0.5 part by weight of carrageenan, 0.3 part by weight of xanthan gum and 0.4 part by weight of locust bean gum in the total weight of the jelly composition.
The jelly composition for improving bronchial health according to claim 1, wherein the cyclodextrin is added in an amount of 11 to 13 parts by weight based on the total weight of the jelly composition.
3. The jelly composition for improving bronchial health according to claim 1, wherein the jelly composition has increased taste and bitter taste.
1) preparing plant extracts for improving bronchial health;
2) mixing cyclodextrin and purified water with the plant extract of step 1), and then stirring to prepare a solution;
3) mixing the additive in the solution of the step 2);
4) dewatering the sugar and the gelling agent and calcium lactate;
5) mixing the gelling agent mixture prepared in the step 4) with the cross-linking solution containing the additive of the step 3), and then stirring the mixture.