CN100998697B - Lozenge made of traditional Chinese medicine for treating throat disease, and its preparing method - Google Patents
Lozenge made of traditional Chinese medicine for treating throat disease, and its preparing method Download PDFInfo
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- CN100998697B CN100998697B CN2007100262095A CN200710026209A CN100998697B CN 100998697 B CN100998697 B CN 100998697B CN 2007100262095 A CN2007100262095 A CN 2007100262095A CN 200710026209 A CN200710026209 A CN 200710026209A CN 100998697 B CN100998697 B CN 100998697B
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Abstract
A Chinese medicine in the form of buccal dozenge for treating throat diseases is prepared from 12 Chinese-medicinal materials including bezoar, isatis root, platycodon root, forysythia fruit, etc and the additives including filler, dextrin, flavouring and lubricant. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of drug port buccal tablet, specifically relate to a kind of traditional Chinese medicine mouth buccal tablet for the treatment of laryngopharyngeal diseases, the present invention also provides the preparation method of this traditional Chinese medicine mouth buccal tablet.
Background technology
Tonsillitis, laryngopharyngeal diseasess such as acute and chronic pharyngitis are modern society's common diseases.Larynx disease curing capsule in the former ministry standard has very favorable effects to the treatment laryngopharyngeal diseases, being in great demand obtains the favorable comment of extensive patients over year surplus in the of ten, but exists the capsule dosage form single, takes inconvenience, the buccal tablet adverse drug abnormal smells from the patient made from common process is heavy, and the patient is difficult to shortcomings such as acceptance.The buccal tablet that the present invention developed utilizes various new techniques, has covered the bad smell of prescription Chinese medicine, is convenient to take.
Summary of the invention
The objective of the invention is to remedy WS in the 5th of the former ministry standard
3The deficiency of-B-1039-91 larynx disease curing capsule dosage form provides a kind of and can directly act on the throat affected part, the traditional Chinese medicine mouth buccal tablet of the rapid persistent treatment laryngopharyngeal diseases of curative effect.
Another object of the present invention provides the preparation method of above-mentioned traditional Chinese medicine mouth buccal tablet, and the preparation method by improvement obtains good mouthfeel, the buccal tablet of the treatment laryngopharyngeal diseases of being convenient to take.
The present invention is achieved through the following technical solutions:
The traditional Chinese medicine mouth buccal tablet of treatment laryngopharyngeal diseases provided by the invention comprises following supplementary material weight portion:
180～280 parts of 220～330 parts of Fructus Chebulaes of 13～20 parts of Radix Isatidis of artificial Calculus Bovis
180～280 parts of 37～55 parts of Fructus Forsythiaes of 220～330 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
220～330 parts of 13～20 parts of Radix Eupatorii Chinensiss of 370～550 parts of Margarita layer powder of Radix Trichosanthis
370～550 parts of 370～550 parts of Radix Wikstroemae of 13～20 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
6～10 parts of 65～150 parts of correctivess of 700～1300 parts of cyclodextrin of filler
12～30 parts of lubricants
The traditional Chinese medicine mouth buccal tablet of treatment laryngopharyngeal diseases provided by the invention comprises the supplementary material weight portion and is preferably:
231 parts of 277 parts of Fructus Chebulaes of 16.8 parts of Radix Isatidis of artificial Calculus Bovis
231 parts of 46 parts of Fructus Forsythiaes of 277 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
277 parts of 16.8 parts of Radix Eupatorii Chinensiss of 462 parts of Margarita layer powder of Radix Trichosanthis
462 parts of 462 parts of Radix Wikstroemae of 16.8 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
7.68 parts of 105 parts of correctivess of 1000 parts of cyclodextrin of filler
15 parts of lubricants
The preferred version of foregoing invention is: filler is that Icing Sugar, correctives are that Oleum menthae, lubricant are magnesium stearate.
The present invention also provides a kind of method for preparing this traditional Chinese medicine mouth buccal tablet, and this method may further comprise the steps:
A. Fructus Chebulae's water concentration shortens thick paste A into.
B. Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 5～8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75%～95% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste B.
C. with thick paste A and B mixing, and add artificial Calculus Bovis and Margarita layer powder, mixing, vacuum drying is ground into fine powder.
D. the Borneolum Syntheticum cyclodextrin inclusion compound is crossed 120 mesh sieves.
E. the fine powder that step c and d are made adds the filler mix homogeneously, adds 80% ethanol and makes soft material in right amount, sieves, and granulates vacuum drying.
F. drying is the good granule granulate that sieves adds correctives, lubricant, mixing, and compacting is in flakes.
The preparation method of above-mentioned traditional Chinese medicine mouth buccal tablet, wherein the independent water of Fructus Chebulae is carried, and following advantage is arranged:
1. the medical material generation chemical reaction that can not carry with other water of compositions such as tannin among the Fructus Chebulae and gallic acid and Fructus Chebulae's main effective ingredient has promptly been preserved in a large amount of loss, curative effect is more remarkable.
2. Fructus Chebulae's pulverizing dose that is used as medicine is big, extracts the back effective ingredient and still is kept in the extracting solution, but be used as medicine behind the extract dry after concentrating, and dose reduces.
The concrete extracting method of Fructus Chebulae is: add the water of 5～15 times of amounts, boiled 0.5～2 hour, extract 1～5 time.
The further preferred version of above-mentioned Fructus Chebulae's extracting method is: add the water of 12 times of amounts, soaked 0.5 hour, boiled 0.5 hour, leach extracting solution; Medicinal residues add 10 times of water gagings and boiled 0.5 hour again, leach extracting solution; Medicinal residues add 10 times of water gagings again and boiled 0.5 hour, and merge extractive liquid, is condensed into thick paste.
Borneolum Syntheticum of the present invention with the cyclodextrin inclusion compound preferred version is: the Borneolum Syntheticum beta-cyclodextrin inclusion compound, press following weight portion proportioning: pure water: beta-schardinger dextrin-: Borneolum Syntheticum=60～95: 5～7.5: 1, get pure water, beta-schardinger dextrin-is put in the container, be heated to 55～65 ℃ and stir and to make dissolving fully, under agitation add Borneolum Syntheticum alcoholic solution (95% ethanol: Borneolum Syntheticum=1～3: 1) fast, stirred 1～3 hour, leave standstill and made to room temperature in 2～4 hours, sucking filtration, filtering residue washs 2 times with 95% ethanol is an amount of, drain filtering residue, 50 ℃ of dryings 3～5 hours were pulverized 120 mesh sieves.
Beneficial effect
The invention provides a kind of traditional Chinese medicine mouth buccal tablet for the treatment of laryngopharyngeal diseases, new dosage form can directly act on disease sites by the oral cavity buccal, helps the performance of its curative effect more, taking convenience.
The advantage of Borneolum Syntheticum enclose and adding Oleum menthae is: the abnormal smells from the patient of Borneolum Syntheticum is not good, and its mouthfeel of back of being used as medicine is difficult to be accepted by the patient, now by the technology of Borneolum Syntheticum enclose, has covered the bad smell of Borneolum Syntheticum.In addition, medical material such as Radix Sophorae Tonkinensis, Radix Trichosanthis taste bitterness, the present invention has covered all bad mouthfeels to greatest extent by adding adjuvants such as Oleum menthae, Icing Sugar, success first made the traditional Chinese medicine mouth buccal tablet that mouthfeel can be accepted by masses, and curative effect more rapidly, directly, having made things convenient for taking of patient, is a very useful invention.
The specific embodiment
Embodiment 1
231 parts of 277 parts of Fructus Chebulaes of 16.8 parts of Radix Isatidis of artificial Calculus Bovis
231 parts of 46 parts of Fructus Forsythiaes of 277 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
277 parts of 16.8 parts of Radix Eupatorii Chinensiss of 462 parts of Margarita layer powder of Radix Trichosanthis
462 parts of 462 parts of Radix Wikstroemae of 16.8 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
7.68 parts of 105 portions of Oleum menthae of Icing Sugar 1000 cyclodextrin
15 parts of magnesium stearate
The Fructus Chebulae adds the water of 12 times of amounts, soaks 0.5 hour, boils 0.5 hour, leaches extracting solution; Medicinal residues add 10 times of water gagings and boiled 0.5 hour again, leach extracting solution; Medicinal residues add 10 times of water gagings again and boiled 0.5 hour, and merge extractive liquid, is condensed into thick paste A.
Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste B.Thick paste A and B mixing, and add artificial Calculus Bovis and Margarita layer powder, mixing, vacuum drying is ground into fine powder.
The Borneolum Syntheticum beta-cyclodextrin inclusion compound, by following weight portion proportioning: pure water: beta-schardinger dextrin-: Borneolum Syntheticum=85: 6.25: 1, get pure water, beta-schardinger dextrin-is put in the container, be heated to 55～65 ℃ and stir and make dissolving fully, under agitation add Borneolum Syntheticum alcoholic solution (95% ethanol: Borneolum Syntheticum=2: 1) fast, stirred 2 hours, and left standstill and made to room temperature sucking filtration in 2～4 hours, filtering residue washs 2 times with 95% ethanol is an amount of, drain filtering residue, 50 ℃ of dryings 4 hours were pulverized 120 mesh sieves.
With above-mentioned fine powder, Borneolum Syntheticum clathrate and Icing Sugar mix homogeneously, add 80% ethanol and make soft material in right amount, sieve, granulate vacuum drying.The granule that drying is the good granulate that sieves adds Oleum menthae, magnesium stearate, mixing, compacting in flakes, promptly.
Embodiment 2
180 parts of 220 parts of Fructus Chebulaes of 13 parts of Radix Isatidis of artificial Calculus Bovis
180 parts of 37 parts of Fructus Forsythiaes of 220 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
220 parts of 13 parts of Radix Eupatorii Chinensiss of 370 parts of Margarita layer powder of Radix Trichosanthis
370 parts of 370 parts of Radix Wikstroemae of 13 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
6 parts of 65 portions of Oleum menthae of 880 parts of cyclodextrin of Icing Sugar
12 parts of magnesium stearate
The Fructus Chebulae adds the water of 15 times of amounts, soaks 1 hour, boils 1 hour, leaches extracting solution; Medicinal residues add 10 times of water gagings and boiled 0.5 hour again, leach extracting solution; Medicinal residues add 10 times of water gagings again and boiled 0.5 hour, and merge extractive liquid, is condensed into thick paste A.
Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste B.Thick paste A and B mixing, and add artificial Calculus Bovis and Margarita layer powder, mixing, vacuum drying is ground into fine powder.
The Borneolum Syntheticum beta-cyclodextrin inclusion compound, by following weight portion proportioning: pure water: beta-schardinger dextrin-: Borneolum Syntheticum=60: 5: 1, get pure water, beta-schardinger dextrin-is put in the container, be heated to 55～65 ℃ and stir and make dissolving fully, under agitation add Borneolum Syntheticum alcoholic solution (95% ethanol: Borneolum Syntheticum=2: 1) fast, stirred 1.5 hours, and left standstill and made to room temperature sucking filtration in 2～4 hours, filtering residue washs 2 times with 95% ethanol is an amount of, drain filtering residue, 50 ℃ of dryings 3 hours were pulverized 120 mesh sieves.
With above-mentioned fine powder, Borneolum Syntheticum clathrate and Icing Sugar mix homogeneously, add 80% ethanol and make soft material in right amount, sieve, granulate vacuum drying.The granule that drying is the good granulate that sieves adds Oleum menthae, magnesium stearate, mixing, compacting in flakes, promptly.
Embodiment 3
280 parts of 330 parts of Fructus Chebulaes of 20 parts of Radix Isatidis of artificial Calculus Bovis
280 parts of 55 parts of Fructus Forsythiaes of 330 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
330 parts of 20 parts of Radix Eupatorii Chinensiss of 550 parts of Margarita layer powder of Radix Trichosanthis
550 parts of 550 parts of Radix Wikstroemae of 20 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
10 parts of 150 portions of Oleum menthae of 1300 parts of cyclodextrin of Icing Sugar
20 parts of magnesium stearate
The Fructus Chebulae adds the water of 12 times of amounts, soaks 0.5 hour, boils 45 minutes, leaches extracting solution; Medicinal residues add 10 times of water gagings and boiled 45 minutes again, and merge extractive liquid, is condensed into thick paste A.
Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste B.Thick paste A and B mixing, and add artificial Calculus Bovis and Margarita layer powder, mixing, vacuum drying is ground into fine powder.
The Borneolum Syntheticum beta-cyclodextrin inclusion compound, by following weight portion proportioning: pure water: beta-schardinger dextrin-: Borneolum Syntheticum=95: 7.5: 1, get pure water, beta-schardinger dextrin-is put in the container, be heated to 55～65 ℃ and stir and make dissolving fully, under agitation add Borneolum Syntheticum alcoholic solution (95% ethanol: Borneolum Syntheticum=1.5: 1) fast, stirred 3 hours, and left standstill and made to room temperature sucking filtration in 4 hours, filtering residue washs 2 times with 95% ethanol is an amount of, drain filtering residue, 50 ℃ of dryings 5 hours were pulverized 120 mesh sieves.
With above-mentioned fine powder, Borneolum Syntheticum clathrate and Icing Sugar mix homogeneously, add 80% ethanol and make soft material in right amount, sieve, granulate vacuum drying.The granule that drying is the good granulate that sieves adds Oleum menthae, magnesium stearate, mixing, compacting in flakes, promptly.
Claims (6)
1. preparation method for the treatment of the traditional Chinese medicine mouth buccal tablet of laryngopharyngeal diseases, it is characterized in that: the supplementary material of this traditional Chinese medicine mouth buccal tablet is made up of following weight portion,
180～280 parts of 220～330 parts of Fructus Chebulaes of 13～20 parts of Radix Isatidis of artificial Calculus Bovis
180～280 parts of 37～55 parts of Fructus Forsythiaes of 220～330 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
220～330 parts of 13～20 parts of Radix Eupatorii Chinensiss of 370～550 parts of Margarita layer powder of Radix Trichosanthis
370～550 parts of 370～550 parts of Radix Wikstroemae of 13～20 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
6～10 parts of 65～150 parts of correctivess of 700～1300 parts of cyclodextrin of filler
12～30 parts of lubricants;
The preparation method of this traditional Chinese medicine mouth buccal tablet may further comprise the steps:
A. Fructus Chebulae's water concentration shortens thick paste A into;
B. Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 5～8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered; Filtrate is condensed into extractum, gets 75%～95% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste B;
C. with thick paste A and B mixing, and add artificial Calculus Bovis and Margarita layer powder, mixing, vacuum drying is ground into fine powder;
D. the Borneolum Syntheticum cyclodextrin inclusion compound is crossed 120 mesh sieves;
E. the fine powder that step c and d are made adds the filler mix homogeneously, adds 80% ethanol and makes soft material in right amount, sieves, and granulates vacuum drying;
F. drying is the good granule granulate that sieves adds correctives, lubricant, mixing, and compacting is in flakes.
2. the preparation method of traditional Chinese medicine mouth buccal tablet according to claim 1 is characterized in that: the supplementary material of this traditional Chinese medicine mouth buccal tablet is made up of following weight portion:
231 parts of 277 parts of Fructus Chebulaes of 16.8 parts of Radix Isatidis of artificial Calculus Bovis
231 parts of 46 parts of Fructus Forsythiaes of 277 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
277 parts of 16.8 parts of Radix Eupatorii Chinensiss of 462 parts of Margarita layer powder of Radix Trichosanthis
462 parts of 462 parts of Radix Wikstroemae of 16.8 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
7.68 parts of 105 parts of correctivess of 1000 parts of cyclodextrin of filler
15 parts of lubricants.
3. the preparation method of traditional Chinese medicine mouth buccal tablet according to claim 1 and 2 is characterized in that: filler is that Icing Sugar, correctives are that Oleum menthae, lubricant are magnesium stearate.
4. the preparation method of traditional Chinese medicine mouth buccal tablet according to claim 1 is characterized in that: among the step a, Fructus Chebulae's extraction process is: add the water of 5～15 times of amounts, soaked 0.5～2 hour, boiled 0.5～2 hour, extract 1～5 time.
5. the preparation method of traditional Chinese medicine mouth buccal tablet according to claim 4, it is characterized in that, Fructus Chebulae's preferred extraction process is: add the water of 12 times of amounts, soaked 0.5 hour, boiled 0.5 hour, leach extracting solution, medicinal residues extract 2 times again, add the water of 10 times of amounts at every turn, boil 0.5 hour, merge extractive liquid, is condensed into thick paste.
6. the preparation method of traditional Chinese medicine mouth buccal tablet according to claim 1, it is characterized in that, Borneolum Syntheticum beta-cyclodextrin inclusion compound in the steps d, press following weight portion proportioning: pure water: beta-schardinger dextrin-: Borneolum Syntheticum=60～95: 5～7.5: 1, get pure water, beta-schardinger dextrin-is put in the container, be heated to 55～65 ℃ and stir and to make dissolving fully, under agitation add 95% ethanol fast: Borneolum Syntheticum=1～3: 1 Borneolum Syntheticum alcoholic solution, stirred 1～3 hour, and left standstill and made to room temperature sucking filtration in 2～4 hours, filtering residue washs 2 times with 95% ethanol is an amount of, drain filtering residue, 50 ℃ of dryings 3～5 hours were pulverized 120 mesh sieves.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108114086A (en) * | 2017-12-04 | 2018-06-05 | 杨忠华 | A kind of throat lozenge and preparation method thereof |
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| CN101623391B (en) * | 2009-08-11 | 2012-06-06 | 朱林 | Medicine for treating acute and chronic tonsillitis and preparation method thereof |
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| Title |
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| 177. * |
| 中华人民共和国卫生部药品标准中药成方制剂第五册.中华人民共和国卫生部药典委员会,1992,Z5-177. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108114086A (en) * | 2017-12-04 | 2018-06-05 | 杨忠华 | A kind of throat lozenge and preparation method thereof |
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