CN107961271A - A kind of medicine for treating stomatitis and preparation method thereof - Google Patents

A kind of medicine for treating stomatitis and preparation method thereof Download PDF

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Publication number
CN107961271A
CN107961271A CN201610914246.9A CN201610914246A CN107961271A CN 107961271 A CN107961271 A CN 107961271A CN 201610914246 A CN201610914246 A CN 201610914246A CN 107961271 A CN107961271 A CN 107961271A
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China
Prior art keywords
parts
medicine
stomatitis
medicinal extract
treatment
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Pending
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CN201610914246.9A
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Chinese (zh)
Inventor
陈修仕
陈才献
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GUIZHOU RUNSHENG PHARMACEUTICAL Co Ltd
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GUIZHOU RUNSHENG PHARMACEUTICAL Co Ltd
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Priority to CN201610914246.9A priority Critical patent/CN107961271A/en
Publication of CN107961271A publication Critical patent/CN107961271A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a kind of medicine for treating stomatitis and preparation method thereof, the medicine is mainly made of the root bark of tree peony, radix glycyrrhizae, radix astragali, granatum, Radix Codonopsis and Fructus Corni.The medicine can be used for treating stomatitis；Evident in efficacy, treatment cycle is short, and safety is without side-effects.

Description

A kind of medicine for treating stomatitis and preparation method thereof
Technical field
The present invention relates to a kind of medicine for treating stomatitis and preparation method thereof, belong to the field of medicine technology.
Background technology
Stomatitis is buccal, tongue side, palate, and ulcer occurs for gums etc., and surrounding redness is had a pain, and ulceration has erosion.Due to The reason for stomatitis, is different, and symptom is also different.Be clinically divided into Catarrhal, aphthous, blister, phlegmonous, it is pseudomembranous, The type such as exedens and papular.Either which kind of stomatitis, its common clinical symptoms all shows as salivating, lose the appetite or Feeding slowly, oral malodor, mucous membrane of mouth flush, heat, swelling and pain.These symptoms of Catarrhal stomatitis are most obvious;Mouthful During sore stomatitis, with white or canescence in the necrotic lesion of small circular on mucous membrane of mouth, its periphery is round red Edge;When suffering from vesicular stomatitis, in mucous membrane of mouth, the bubble of transparent sample occurs for the inner side of tongue and lip, through 3-4 sky and water After blister ulceration, there is the speck of kermesinus.When catching a foot and mouth disease, blister also betide between coronet, heel, toe and breast and with Thermal sensation, in addition this disease have very strong infectiousness;When suffering from phlegmonous stomatitis, it is seen that lip, maxilla and respiratory tract week Existing fluctuation sample swelling is crossed, often occurs crepitus after compressing;When suffering from pseudomembranous stomatitis, cheese is suffered from mucous membrane of mouth Sample, turns white a little or even the pseudomembrane with lark, this pseudomembrane are made of cellulose and slough;Suffer from exedens mouth When chamber is scorching, ulcer occurs on mucous membrane of mouth, and tissue defect occur;When suffering from papular stomatitis, in the inner side of lip and week Enclose, tongue, the flat lesser tubercle to mostly occur in yellow-white barnyard grass Seed size in full oral cavity, contagiousness is very strong.
For above-mentioned disease, although having much currently used for the medicine for treating stomatitis, most drugs are pin It is slow to drug effect, treatment cycle length.
The content of the invention
It is an object of the present invention to provide a kind of medicine for treating stomatitis and preparation method thereof.The medicine can be used for Treat stomatitis；Evident in efficacy, treatment cycle is short, and safety is without side-effects.
In order to solve the above technical problems, the present invention is realized using following technical scheme：A kind of medicine for treating stomatitis, is pressed Listed as parts by weight, mainly by 1-20 parts of the root bark of tree peony, 20-40 parts of radix glycyrrhizae, 30-50 parts of radix astragali, 10-30 parts of granatum, 20-40 parts of Radix Codonopsis It is made for 10-30 parts with Fructus Corni.
The medicine of foregoing treatment stomatitis, calculates, mainly by 5-15 parts of the root bark of tree peony, 25-35 parts of radix glycyrrhizae, radix astragali by weight 35-45 parts, 15-25 parts of granatum, 15-25 parts of 25-35 parts of Radix Codonopsis and Fructus Corni be made.
The medicine of foregoing treatment stomatitis, calculates by weight, mainly by 10 parts of the root bark of tree peony, 30 parts of radix glycyrrhizae, 40 parts of radix astragali, 20 parts of 20 parts of granatum, 30 parts of Radix Codonopsis and Fructus Corni are made.
A kind of production method of the medicine of foregoing treatment stomatitis, takes said medicine, can add auxiliary material, can also be not added with Auxiliary material, is made oral formulations.
The production method of the medicine of foregoing treatment stomatitis, the oral formulations are granule, capsule, tablet, ball Agent, powder or creme.
The production method of the medicine of foregoing treatment stomatitis, the granule so make：Said medicine is taken, adds 10 times Measure water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, and relative density is the leaching of 1.15-1.20 when being condensed into 50-60 DEG C Cream, medicinal extract and the starch and 20% dextrine powder mixing granulation of medicinal extract amount 20%, it is dry, to obtain the final product.
The production method of the medicine of foregoing treatment stomatitis, the production method of the capsule are：Said medicine is taken, is used The alcohol reflux of 6 times of amounts 70% extracts 2 times, every time 1 it is small when, extracting solution filtering, filtrate recycling ethanol and when being condensed into 50-60 DEG C Relative density is the medicinal extract of 1.20-1.25, and the starch and 0.7% magnesium stearate for separately taking medicinal extract amount 30% are mixed with medicinal extract, with 60% Alcohol granulation, dry, pulverize, fill capsule, to obtain the final product.
The production method of the medicine of foregoing treatment stomatitis, the production method of the tablet are：Said medicine is taken, adds 10 Times amount water decoct 3 times, each 1.5h, filtering, merge decoction liquor, when being condensed into 50-60 DEG C relative density be 1.15-1.20 leaching Cream, medicinal extract are mixed with above-mentioned mixed powder and the starch of medicinal extract amount 20%, tabletting, film coating, to obtain the final product.
Compared with prior art, medicine of the present invention mainly by the root bark of tree peony, radix glycyrrhizae, radix astragali, granatum, radix astragali, Radix Codonopsis and Fructus Corni is made.Each raw material has synergistic effect well in prescription, available for treating stomatitis；It is evident in efficacy, treatment Cycle is short, and safety is without side-effects.
Embodiment：
Embodiment 1.
Formula：Root bark of tree peony 10kg, radix glycyrrhizae 30kg, radix astragali 40kg, granatum 20kg, Radix Codonopsis 30kg and Fructus Corni 20kg.
Technique：10 times of amount water are added to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into relatively close at 50-60 DEG C The medicinal extract for 1.15-1.20, medicinal extract and the starch and 20% dextrine powder mixing granulation of medicinal extract amount 20% are spent, it is dry, up to particle Agent.
Specification：5g/ bags.
Usage and dosage：Each 5-10g, it is 2-3 times daily.
Embodiment 2.
Formula：Root bark of tree peony 10kg, radix glycyrrhizae 30kg, radix astragali 40kg, granatum 20kg, Radix Codonopsis 30kg and Fructus Corni 20kg.
Technique：Take said medicine, with 6 times amount 70% alcohol reflux extract 2 times, every time 1 it is small when, extracting solution filtering, filtrate The medicinal extract that relative density is 1.20-1.25 when recycling ethanol and being condensed into 50-60 DEG C, separately takes the starch and 0.7% of medicinal extract amount 30% Magnesium stearate and medicinal extract mix, with 60% alcohol granulation, dry, pulverize, capsule filled, up to capsule.
Specification：0.3g/.
Usage and dosage：Each 5-10g, it is 2-3 times daily.
Embodiment 3.
Formula：Root bark of tree peony 10kg, radix glycyrrhizae 30kg, radix astragali 40kg, granatum 20kg, Radix Codonopsis 30kg and Fructus Corni 20kg.
Technique：Said medicine is taken, adds 10 times of amount water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into 50- Relative density is the medicinal extract of 1.15-1.20 at 60 DEG C, and medicinal extract is mixed with above-mentioned mixed powder and the starch of medicinal extract amount 20%, tabletting, bag Film-coating, up to tablet.
Specification：0.3g/ pieces.
Usage and dosage：Each 5-10g, it is 2-3 times daily.

Claims (8)

  1. A kind of 1. medicine for treating stomatitis, it is characterised in that：Calculate by weight, mainly by 1-20 parts of the root bark of tree peony, radix glycyrrhizae 20-40 Part, 30-50 parts of radix astragali, 10-30 parts of granatum, 20-40 parts of Radix Codonopsis and 10-30 parts of Fructus Corni are made.
  2. 2. the medicine for the treatment of stomatitis as claimed in claim 1, it is characterised in that：Calculate by weight, mainly by root bark of tree peony 5- 15-25 parts of 15 parts, 25-35 parts of radix glycyrrhizae, 35-45 parts of radix astragali, 15-25 parts of granatum, 25-35 parts of Radix Codonopsis and Fructus Corni make and Into.
  3. 3. the medicine for the treatment of stomatitis as claimed in claim 2, it is characterised in that：Calculate by weight, mainly by the root bark of tree peony 10 20 parts of part, 30 parts of radix glycyrrhizae, 40 parts of radix astragali, 20 parts of granatum, 30 parts of Radix Codonopsis and Fructus Corni are made.
  4. A kind of 4. production method of the medicine for the treatment of stomatitis as any one of claim 1-3, it is characterised in that：Take Said medicine, can add auxiliary material, can also be not added with auxiliary material, oral formulations are made.
  5. 5. the production method of the medicine for the treatment of stomatitis as claimed in claim 4, it is characterised in that：The oral formulations are Granula, capsule, tablet, pill, powder or creme.
  6. 6. the production method of the medicine for the treatment of stomatitis as claimed in claim 5, it is characterised in that：The granule is so made Make：Said medicine is taken, adds 10 times of amount water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into opposite at 50-60 DEG C Density is the starch and 20% dextrine powder mixing granulation of the medicinal extract of 1.15-1.20, medicinal extract and medicinal extract amount 20%, dry, to obtain the final product.
  7. 7. the production method of the medicine for the treatment of stomatitis as claimed in claim 5, it is characterised in that：The making of the capsule Method is：Take said medicine, with 6 times amount 70% alcohol reflux extract 2 times, every time 1 it is small when, extracting solution filtering, filtrate recycling second Alcohol and relative density is the medicinal extract of 1.20-1.25 when being condensed into 50-60 DEG C, separately takes the starch of medicinal extract amount 30% and 0.7% tristearin Sour magnesium is mixed with medicinal extract, with 60% alcohol granulation, dry, pulverize, and fills capsule, to obtain the final product.
  8. 8. the production method of the medicine for the treatment of stomatitis as claimed in claim 5, it is characterised in that：The making side of the tablet Method is：Said medicine is taken, adds 10 times of amount water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into 50-60 DEG C of phase To the medicinal extract that density is 1.15-1.20, medicinal extract is mixed with above-mentioned mixed powder and the starch of medicinal extract amount 20%, tabletting, film coating, To obtain the final product.
CN201610914246.9A 2016-10-20 2016-10-20 A kind of medicine for treating stomatitis and preparation method thereof Pending CN107961271A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610914246.9A CN107961271A (en) 2016-10-20 2016-10-20 A kind of medicine for treating stomatitis and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610914246.9A CN107961271A (en) 2016-10-20 2016-10-20 A kind of medicine for treating stomatitis and preparation method thereof

Publications (1)

Publication Number Publication Date
CN107961271A true CN107961271A (en) 2018-04-27

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108704077A (en) * 2018-08-09 2018-10-26 北京生泰尔科技股份有限公司 A kind of Chinese veterinary medicinal composition and preparation method thereof for treating cat stomatitis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108704077A (en) * 2018-08-09 2018-10-26 北京生泰尔科技股份有限公司 A kind of Chinese veterinary medicinal composition and preparation method thereof for treating cat stomatitis
CN108704077B (en) * 2018-08-09 2021-08-10 北京生泰尔科技股份有限公司 Traditional Chinese veterinary medicine composition for treating cat stomatitis and preparation method thereof

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Application publication date: 20180427