CN108704077A - A kind of Chinese veterinary medicinal composition and preparation method thereof for treating cat stomatitis - Google Patents
A kind of Chinese veterinary medicinal composition and preparation method thereof for treating cat stomatitis Download PDFInfo
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- CN108704077A CN108704077A CN201810899838.7A CN201810899838A CN108704077A CN 108704077 A CN108704077 A CN 108704077A CN 201810899838 A CN201810899838 A CN 201810899838A CN 108704077 A CN108704077 A CN 108704077A
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- 208000003265 stomatitis Diseases 0.000 title claims abstract description 55
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- 238000002360 preparation method Methods 0.000 title claims abstract description 11
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- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/8968—Ophiopogon (Lilyturf)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses a kind of Chinese veterinary medicinal compositions and preparation method thereof for treating cat stomatitis, it is characterised in that：10~30 parts of Radix Rehmanniae, 5~15 parts of lotus nut, 10~40 parts of Chinese violet, 5~20 parts of honeysuckle, 5~20 parts of Radix Ophiopogonis, 5~20 parts of lophatherum gracile, 10~30 parts of Radix Astragali, 5~20 parts of Radix Codonopsis, 5~10 parts of the fruit of glossy privet, 5~20 parts of Radix Glycyrrhizae, the water of 10~12 times of amounts of medicinal material total weight is added, it decocts twice, it decocts 1.0 hours every time, filtration, filtrate, filtrate decompression are concentrated into relative density 1.10~1.20 (60 DEG C), corresponding preparations are made by the preparation process of required dosage form twice for merging.The present invention has preferable therapeutic effect to cat stomatitis, can alleviate the symptoms such as the salivation of disease cat, halitosis and oral mucosa redness, accelerates oral ulcer surface healing, reduces the recurrence rate for curing sick cat stomatitis.
Description
Technical field
The invention belongs to pet field of pharmaceutical technology, and in particular to it is a kind of for treat cat stomatitis Chinese veterinary medicinal composition and
Preparation method.
Background technology
With socio-economic development and the promotion of people's quality of the life, China's pet industry is developed rapidly, pet
Health is also increasingly subject to the attention of pet owner and pet doctor.Cat stomatitis ulcer disease is very common in clinic
One of disease, it is clinical in vagrant cat and domestic cat have morbidity, wherein again in the majority with vagrant cat.The disease inducement is complex, such as
By various sharp foreign matters, such as the stimulation of osteocomma, thorn, iron wire, draw point, wood thorn, irregular tooth is damaged, and is eaten
With corrosive chemical toxicant or be deficient in vitamin A, B2 etc., the generation of stomatitis all may result in.In addition, as certain infections
Disease, such as cat bronchitis virus, cat calicivirus, are the pathogenies for causing the exedens glossitis of cat, certain systemic diseases, poor
Blood can also cause the generation of stomatitis.The appetite for suffering from cat is reduced or is lost to some extent, and feeding, chewing are abnormal, and the course of disease is compared with elder
Weight loss is apparent, extremely becomes thin, apathetic depressed, and oral mucosa irritation, ulcer, pain cannot be suck and be chewed, a large amount of head pieces
Water, common foam-like saliva around lip, there is stink.Disease treatment at present, will depending on the state of an illness mainly by conventional method treatment of having tooth pulled out
Suffer from half mouthful of cat or denture is pulled out, then is aided with antibiosis extract for treating.But there is higher recurrence using this method treatment cat stomatitis
Rate, studies have shown that taking the high recurrence rate of half mouthful of extraction therapy up to 47.06%, recurrence period is generally 30-90 days, is adopted
It is 16.67% to take the therapy recurrence rate that extraction is completely cured, and recurrence period is generally 7-14 days, takes the recurrence rate of full mouth extraction
It is 15.38%, recurrence period is generally 90 days or more.In addition, not only needing to be subjected to huge pain using the cat that suffers from of extraction treatment
Hardship, and later life gum fraction can only feed liquid food or half liquid food.
Invention content
The present invention is directed to be directed to the various drawbacks of the prior art and deficiency, based on Chinese veterinarian's theory, in conjunction with clinical practice
Experience provides Chinese veterinary medicinal composition that is a kind of significant in efficacy and suffering from cat non-invasive therapy to cat stomatitis.
To achieve the above object, inventor is studied by long-term practice based on Chinese veterinarian's pharmacology opinion, is filtered out this hair
Bright formula, feature are as follows：
A kind of Chinese veterinary medicinal composition for treating cat stomatitis, drug composition are expressed as with parts by weight：5~50 parts of Radix Rehmanniae,
3~30 parts of lotus nut, 5~60 parts of Chinese violet, 3~30 parts of honeysuckle, 3~30 parts of Radix Ophiopogonis, 3~30 parts of lophatherum gracile, Radix Astragali 5~
50 parts, 3~30 parts of Radix Codonopsis, 3~20 parts of the fruit of glossy privet, 3~30 parts of Radix Glycyrrhizae.
A kind of Chinese veterinary medicinal composition for treating cat stomatitis, drug composition are expressed as with parts by weight：10~30 parts of Radix Rehmanniae,
5~15 parts of lotus nut, 10~40 parts of Chinese violet, 5~20 parts of honeysuckle, 5~20 parts of Radix Ophiopogonis, 5~20 parts of lophatherum gracile, Radix Astragali 10
~30 parts, 5~20 parts of Radix Codonopsis, 5~10 parts of the fruit of glossy privet, 5~20 parts of Radix Glycyrrhizae.
A kind of Chinese veterinary medicinal composition for treating cat stomatitis, drug are formed and are indicated with parts by weight, preferably：Radix Rehmanniae 15
Part, 10 parts of lotus nut, 25 parts of Chinese violet, 10 parts of honeysuckle, 10 parts of Radix Ophiopogonis, 10 parts of lophatherum gracile, 15 parts of Radix Astragali, 10 parts of Radix Codonopsis,
5 parts of the fruit of glossy privet, 10 parts of Radix Glycyrrhizae.
The present invention is made using industry universal method water extraction：Number weighs each medicinal material according to the required weight, and it is total that medicinal material is added
10~12 times of water measured of weight, decoct twice, decoct 1.0 hours every time, filtration, filtrate, filtrate decompression are concentrated into twice for merging
Relative density 1.15~1.20 (60 DEG C), by the preparation process of required dosage form be made corresponding preparations to get.
The application mode in pharmaceutical field of the present composition is：By above-mentioned composition be raw material be prepared into oral solution,
The internal dosage forms such as pulvis, granule, tablet, capsule, paste.
The composition principle of the present invention is as follows：
Differential diagnosis in tcm thinks that the cat stomatitis cause of disease is complicated, it is outer mostly with rushed in wind, fire, dryness evil or oral cavity is unclean, it is damaged evil in mouth
Poison directly enter it is related, it is inside mostly in close relations with the visceral dysfunctions such as the heart, spleen, kidney.The rules for the treatment of are with clearing heat and detoxicating, nourishing yin and lessening fire, yin-nourishing
Promote the production of body fluid, strengthen the body resistance to consolidate the constitution based on.In prescription of the present invention, Chinese violet, honeysuckle, lotus nut, lophatherum gracile, clearing heat and detoxicating, cool blood disappear
Swollen, purging intense heat relieving restlessness, restoring normal coordination between heart and kidney are monarch drug in a prescription；Radix Rehmanniae, Radix Ophiopogonis, nourishing Yin and promoting production of body fluid, cool blood clear away heart-fire, and are ministerial drug；Radix Astragali, Radix Codonopsis, glossy privet
Son, invigorating the spleen righting consolidate blood-nourishing, are adjutant；Radix Glycyrrhizae is invigorated the spleen and benefited qi, relieving spasm to stop pain, coordinating the drug actions of a prescription, to make medicine.
Invention has following advantage and effect compared with the existing technology：
The present invention is the Chinese veterinary medicinal composition that a kind of source natural plants are used to treat cat stomatitis, passes through the side of administration for oral administration
Formula, the effect of playing clearing heat and detoxicating, nourishing yin and lessening fire, nourishing Yin and promoting production of body fluid, strengthen the body resistance to consolidate the constitution, the internal organs such as the cat heart, spleen, kidney are suffered from multipath adjusting
Function, can safely, it is noninvasive, the symptoms such as the salivation of cat stomatitis disease cat, halitosis and oral mucosa redness are effectively relieved, accelerate canker sore
Face healing promotes weight recovery.It is unaffected and uneasy to recur to cure future trouble cat quality of life, can also mitigate because operation is had tooth pulled out
Treat the financial burden brought to pet owner and psychological pressure.
Specific implementation mode
With reference to embodiment, the present invention is described further, as described below, is only the preferable implementation to the present invention
Example, not limits the present invention, any person skilled in the art is possibly also with the disclosure above
Technology contents be changed to the equivalent embodiment changed on an equal basis.Without departing from the concept of the present invention, according to the present invention
Technical spirit any simple modification that following embodiment is made or equivalent variations, all fall in protection scope of the present invention.
Embodiment 1：A kind of Chinese veterinary medicinal composition for treating cat stomatitis, is made of agents：Take 15 parts of Radix Rehmanniae, lotus nut
10 parts, 25 parts of Chinese violet, 10 parts of honeysuckle, 10 parts of Radix Ophiopogonis, 10 parts of lophatherum gracile, 15 parts of Radix Astragali, 10 parts of Radix Codonopsis, 5 parts of the fruit of glossy privet,
The water of 10 times of amounts of medicinal material total weight is added in 10 parts of Radix Glycyrrhizae, decocts twice, decocts 1.0 hours every time, and filtration merges filtrate twice,
Filtrate decompression is concentrated into relative density 1.12 (60 DEG C), and potassium sorbate 2.5g, sodium benzoate 2.5g, chicken essence 5g is added, and mixes
Even, for 24 hours, filtration, filtrate adds water to adjust total amount to 1000ml, and sterilizing is filling to get for treating in cat stomatitis for 4 DEG C of refrigerations
Veterinary drug oral solution.
Embodiment 2：A kind of Chinese veterinary medicinal composition for treating cat stomatitis, is made of agents：Take 20 parts of Radix Rehmanniae, lotus nut
15 parts, 30 parts of Chinese violet, 15 parts of honeysuckle, 15 parts of Radix Ophiopogonis, 15 parts of lophatherum gracile, 15 parts of Radix Astragali, 15 parts of Radix Codonopsis, 5 parts of the fruit of glossy privet,
The water of 10 times of amounts of medicinal material total weight is added in 10 parts of Radix Glycyrrhizae, decocts twice, decocts 1.0 hours every time, and filtration merges filtrate twice,
Filtrate decompression is concentrated into relative density 1.10 (60 DEG C), and potassium sorbate 2.5g, sodium benzoate 2.5g, chicken essence 5g is added, and mixes
Even, for 24 hours, filtration, filtrate adds water to adjust total amount to 1000ml, and sterilizing is filling to get for treating in cat stomatitis for 4 DEG C of refrigerations
Veterinary drug oral solution.
Embodiment 3：A kind of Chinese veterinary medicinal composition for treating cat stomatitis, is made of agents：Take 30 parts of Radix Rehmanniae, lotus nut
10 parts, 25 parts of Chinese violet, 5 parts of honeysuckle, 20 parts of Radix Ophiopogonis, 10 parts of lophatherum gracile, 20 parts of Radix Astragali, 5 parts of Radix Codonopsis, 10 parts of the fruit of glossy privet,
The water of 10 times of amounts of medicinal material total weight is added in 20 parts of Radix Glycyrrhizae, decocts twice, decocts 1.0 hours every time, and filtration merges filtrate twice,
Filtrate decompression is concentrated into relative density 1.12 (60 DEG C), and potassium sorbate 2.5g, sodium benzoate 2.5g, chicken essence 5g is added, and mixes
Even, for 24 hours, filtration, filtrate adds water to adjust total amount to 1000ml, and sterilizing is filling to get for treating in cat stomatitis for 4 DEG C of refrigerations
Veterinary drug oral solution.
Embodiment 4：The parts by weight relationship for not following this formulation of drug, arbitrarily carries out prescription, weighs 30 parts of Radix Rehmanniae, lotus
8 parts of the sub- heart, 25 parts of Chinese violet, 40 parts of honeysuckle, 20 parts of Radix Ophiopogonis, 10 parts of lophatherum gracile, 3 parts of Radix Astragali, 5 parts of Radix Codonopsis, the fruit of glossy privet 10
The water of 10 times of amounts of medicinal material total weight are added in part, 20 parts of Radix Glycyrrhizae, decoct twice, every time decoction 1.0 hours, filtration, and merging is filtered twice
Liquid, filtrate decompression are concentrated into relative density 1.11 (60 DEG C), and potassium sorbate 2.5g, sodium benzoate 2.5g, chicken essence 5g is added,
Mixing, for 24 hours, filtration, filtrate adds water to adjust total amount to 1000ml, and sterilizing is filling to get for treating cat stomatitis for 4 DEG C of refrigerations
Traditional Chinese veterinary medicine oral solution.
Embodiment 5：The compatibility relationship of this formulation of drug is not followed, is arbitrarily chosen formulation of drug and is carried out prescription, weighs
The water of 10 times of amounts of medicinal material total weight is added in 10 parts of Radix Rehmanniae, 10 parts of lotus nut, 5 parts of honeysuckle, 20 parts of Radix Astragali, 15 parts of Radix Glycyrrhizae, decocts
Twice, it decocts 1.0 hours every time, filtration, merges filtrate, filtrate decompression twice and be concentrated into relative density 1.12 (60 DEG C), be added
Potassium sorbate 2.5g, sodium benzoate 2.5g, chicken essence 5g, mixing, for 24 hours, filtration, filtrate adds water adjustment total amount extremely for 4 DEG C of refrigerations
1000ml, sterilizing, the filling Traditional Chinese veterinary medicine oral solution to get for treating cat stomatitis.
Embodiment 6：A kind of Chinese veterinary medicinal composition for treating cat stomatitis, is made of agents：Take 10 parts of Radix Rehmanniae, lotus nut
10 parts, 20 parts of Chinese violet, 20 parts of honeysuckle, 5 parts of Radix Ophiopogonis, 20 parts of lophatherum gracile, 30 parts of Radix Astragali, 20 parts of Radix Codonopsis, 10 parts of the fruit of glossy privet,
The water of 10 times of amounts of medicinal material total weight is added in 5 parts of Radix Glycyrrhizae, decocts twice, decocts 1.0 hours every time, and filtration merges filtrate twice,
Filtrate decompression is concentrated into relative density 1.17 (60 DEG C), spray drying, and chicken liver meal is added and adjusts total amount to 200g to get for controlling
Treat the herbal medicine pulvis of cat stomatitis.
Embodiment 7：A kind of Chinese veterinary medicinal composition for treating cat stomatitis, is made of agents：Take 25 parts of Radix Rehmanniae, lotus nut
5 parts, 10 parts of Chinese violet, 10 parts of honeysuckle, 15 parts of Radix Ophiopogonis, 5 parts of lophatherum gracile, 10 parts of Radix Astragali, 10 parts of Radix Codonopsis, 10 parts of the fruit of glossy privet,
The water of 10 times of amounts of medicinal material total weight is added in 15 parts of Radix Glycyrrhizae, decocts twice, decocts 1.0 hours every time, and filtration merges filtrate twice,
Filtrate decompression is concentrated into relative density 1.20 (60 DEG C), spray drying, and chicken liver meal is added and adjusts total amount to 200g to get for controlling
Treat the herbal medicine pulvis of cat stomatitis.
Embodiment 8：A kind of Chinese veterinary medicinal composition for treating cat stomatitis, is made of agents：Take 15 parts of Radix Rehmanniae, lotus nut
15 parts, 40 parts of Chinese violet, 15 parts of honeysuckle, 10 parts of Radix Ophiopogonis, 15 parts of lophatherum gracile, 25 parts of Radix Astragali, 10 parts of Radix Codonopsis, the fruit of glossy privet 10
The water of 10 times of amounts of medicinal material total weight are added in part, 10 parts of Radix Glycyrrhizae, decoct twice, every time decoction 1.0 hours, filtration, and merging is filtered twice
Liquid, filtrate decompression are concentrated into relative density 1.17 (60 DEG C), spray drying, be added chicken liver meal adjust total amount to 200g to get with
In the herbal medicine pulvis for the treatment of cat stomatitis.
Embodiment 9：A kind of Chinese veterinary medicinal composition for treating cat stomatitis, is made of agents：Take 20 parts of Radix Rehmanniae, lotus nut
10 parts, 15 parts of Chinese violet, 20 parts of honeysuckle, 15 parts of Radix Ophiopogonis, 15 parts of lophatherum gracile, 20 parts of Radix Astragali, 10 parts of Radix Codonopsis, 5 parts of the fruit of glossy privet,
The water of 10 times of amounts of medicinal material total weight is added in 20 parts of Radix Glycyrrhizae, decocts twice, decocts 1.0 hours every time, and filtration merges filtrate twice,
Filtrate decompression is concentrated into relative density 1.18 (60 DEG C), and spray drying obtains extract；Add chicken liver meal 200g, mannitol
Particle is made using 70% ethyl alcohol as wetting agent in 75g, polyethylene glycol 20g, calcium carbonate 25g, mixing, dry, adds particle
The magnesium stearate of gross weight 1%, mixing carry out tabletting with the specification of every 0.5g, there are 1000 to get for treating cat stomatitis
Herbal medicine tablet.
Embodiment 10：A kind of Chinese veterinary medicinal composition for treating cat stomatitis, is made of agents：Take 15 parts of Radix Rehmanniae, lotus seeds
5 parts of the heart, 35 parts of Chinese violet, 20 parts of honeysuckle, 20 parts of Radix Ophiopogonis, 15 parts of lophatherum gracile, 30 parts of Radix Astragali, 20 parts of Radix Codonopsis, the fruit of glossy privet 10
The water of 10 times of amounts of medicinal material total weight are added in part, 10 parts of Radix Glycyrrhizae, decoct twice, every time decoction 1.0 hours, filtration, and merging is filtered twice
Liquid, filtrate decompression are concentrated into relative density 1.18 (60 DEG C), and spray drying obtains extract；Add chicken liver meal 200g, mannitol
Particle is made using 70% ethyl alcohol as wetting agent in 75g, polyethylene glycol 20g, calcium carbonate 25g, mixing, dry, adds particle
The magnesium stearate of gross weight 1%, mixing carry out tabletting with the specification of every 0.5g, there are 1000 to get for treating cat stomatitis
Herbal medicine tablet.
Embodiment 11：A kind of Chinese veterinary medicinal composition for treating cat stomatitis, is made of agents：Take 10 parts of Radix Rehmanniae, lotus seeds
15 parts of the heart, 25 parts of Chinese violet, 10 parts of honeysuckle, 5 parts of Radix Ophiopogonis, 10 parts of lophatherum gracile, 30 parts of Radix Astragali, 10 parts of Radix Codonopsis, the fruit of glossy privet 10
The water of 10 times of amounts of medicinal material total weight are added in part, 5 parts of Radix Glycyrrhizae, decoct twice, every time decoction 1.0 hours, filtration, and merging is filtered twice
Liquid, filtrate decompression are concentrated into relative density 1.19 (60 DEG C), and spray drying obtains extract；Add chicken liver meal 200g, mannitol
Particle is made using 70% ethyl alcohol as wetting agent in 75g, polyethylene glycol 20g, calcium carbonate 25g, mixing, dry, adds particle
The magnesium stearate of gross weight 1%, mixing carry out tabletting with the specification of every 0.5g, there are 1000 to get for treating cat stomatitis
Herbal medicine tablet.
Treat cat stomatitis clinical test
(1) experiment material
Animal：Clinically suffer from the sick cat 90 of stomatitis.
Trial drug：Traditional Chinese veterinary medicine oral solution made from Examples 1 to 5 is to should be used as one~liquid of liquid five.
(2) suffer from the clinical symptoms of cat stomatitis
Feeding, chewing are abnormal, or even do not eat, and the course of disease is decreased obviously compared with elder's weight, is extremely become thin, and performance is not when feed
Peace, raises a howl because food stimulus to inflammation part causes pain, and mucous membrane of mouth is red and swollen, and mouth temperature increases, happiness drinking-water, in mouth
Breathe out offensive gases.Oral cavity salivation is serious, bicker band white foam.Normally, but body temperature also can be inclined when being in a bad way for body temperature
Height, when developing into vesicular stomatitis, it can be seen that the blister to differ in size occurs in mucous membrane of mouth；Develop into stomacace
When, there are the symptoms such as rotten, downright bad patch, erosion on mucous membrane.It is diagnosed as cat stomatitis according to above-mentioned symptom confirmation.
(3) therapy
By the sick cat with cat stomatitis, it is included in sequence according to case, requires to be divided into 6 according to clinical research randoming scheme
Group, every group 15, respectively one group of liquid, two groups of liquid, three groups of liquid, four groups of liquid, five groups of liquid and conventional therapy control
Group (hereinafter referred to as control group).After giving respective handling respectively, continuous call-on back by phone was to 90 days.
Five groups of one group~liquid of liquid：1% liquor potassic permanganate is used to wash sick cat oral cavity first daily, then with 5ml/kg
The dosage of weight gavages one~liquid of liquid five respectively, 2 times a day, successive administration 5 days.
Control group：It is different mainly using conventional extraction method treatment according to the state of an illness：1. half mouthful of tooth is pulled out and (removes 4 dogs
Outside tooth and cutting, other teeth are pulled out)；2. denture is pulled out.Fasting 4 days after operation can drink water for postoperative 2nd day, hard
Oral antibiotic can be changed to metronidazole infusion treatment by holding after 3-5 days, the 5th day treats 7 days.
(4) curative effect determinate standard
Recovery from illness：Feeding, chewing restore normal, and oral ulcer surface healing, mucous membrane is normal, oral cavity salivation phenomenon without exception, mouth
Chamber smell has larger improvement；
Effectively：Feeding, chewing make moderate progress, and can still shout a shout in feeding process, and canker sore area reduces, and mucous membrane is red
Swollen phenomenon mitigates, and oral cavity salivates degree and reduces, and oral cavity smell is mitigated；
In vain：Feeding, chewing have no improvement, and food refusal phenomenon is apparent, and the increase or constant of canker sore area, reddening and swelling of mucosa is existing
As aggravating, oral cavity salivation degree aggravates or has no that improvement, oral peculiar smell aggravate or have no improvement.
(5) therapeutic effect：Statistics is specifically shown in Tables 1 and 2.
1 cat stomatitis treatment results statistical form of table
Note：Compared with the control group, a indicates significant difference (P<0.05)；Compared with four groups of liquid, b indicates significant difference (P<
0.05)；Compared with five groups of liquid, c indicates significant difference (P<0.05).
As can be seen from Table 1, in the therapeutic effect for treating cat stomatitis, three groups of one group~liquid of liquid and liquid four
Five groups of group, liquid comparing differences significantly (P<0.05), compared with the control group difference not significantly (P>0.05).
Table 2 cures disease cat stomatitis recurrence statistical form
| Group | Recovery from illness number (only) | Number (only) is recurred in 90 days | Recurrence rate after healing |
| One group of liquid | 11 | 1 | 9.1% |
| Two groups of liquid | 9 | 1 | 11.1% |
| Three groups of liquid | 10 | 1 | 10.0% |
| Four groups of liquid | 5 | 2 | 40.0% |
| Five groups of liquid | 2 | 1 | 50.0% |
| Control group | 9 | 3 | 33.3% |
As can be seen from Table 2, in the influence for the recurrence rate after healing of sick cat stomatitis, three groups of one group~liquid of liquid is less than
Four groups of liquid, five groups of liquid and control group.
The above test results show that the Chinese veterinary medicinal composition of the present invention has preferable therapeutic effect to cat stomatitis, can delay
The symptoms such as the salivation of cat stomatitis disease cat oral cavity, halitosis and mucous membrane of mouth redness are solved, accelerate oral ulcer surface healing, and can be to a certain degree
It is upper to reduce the recurrence rate for curing sick cat stomatitis.
Claims (5)
1. a kind of Chinese veterinary medicinal composition for treating cat stomatitis, which is characterized in that be made of the bulk pharmaceutical chemicals of following parts by weight：Radix Rehmanniae
5~50 parts, 3~30 parts of lotus nut, 5~60 parts of Chinese violet, 3~30 parts of honeysuckle, 3~30 parts of Radix Ophiopogonis, lophatherum gracile 3~30
Part, 5~50 parts of Radix Astragali, 3~30 parts of Radix Codonopsis, 3~20 parts of the fruit of glossy privet, 3~30 parts of Radix Glycyrrhizae.
2. the Chinese veterinary medicinal composition for the treatment of cat stomatitis according to claim 1, which is characterized in that in the drug composition
The parts by weight of each bulk pharmaceutical chemicals are：10~30 parts of Radix Rehmanniae, 5~15 parts of lotus nut, 10~40 parts of Chinese violet, honeysuckle 5~20
Part, 5~20 parts of Radix Ophiopogonis, 5~20 parts of lophatherum gracile, 10~30 parts of Radix Astragali, 5~20 parts of Radix Codonopsis, 5~10 parts of the fruit of glossy privet, Radix Glycyrrhizae 5~20
Part.
3. according to claim 1,2 treatment cat stomatitis Chinese veterinary medicinal composition, it is characterised in that the bulk pharmaceutical chemicals with
Parts by weight meter is preferably：15 parts of Radix Rehmanniae, 10 parts of lotus nut, 25 parts of Chinese violet, 10 parts of honeysuckle, 10 parts of Radix Ophiopogonis, lophatherum gracile
10 parts, 15 parts of Radix Astragali, 10 parts of Radix Codonopsis, 5 parts of the fruit of glossy privet, 10 parts of Radix Glycyrrhizae.
4. according to the Chinese veterinary medicinal composition of any treatment cat stomatitis in claims 1 to 3, which is characterized in that described
Raw material medicament preparation is as follows：Number weighs each medicinal material according to the required weight, and the water of 10~12 times of amounts of medicinal material total weight is added, and decocts
Twice, it decocts 1.0 hours every time, filtration, filtrate, filtrate decompression are concentrated into relative density 1.10~1.20 (60 twice for merging
DEG C), by the preparation process of required dosage form be made corresponding preparations to get.
5. application of the Chinese veterinary medicinal composition according to any one of claims 1 to 4 in the drug for preparing treatment cat stomatitis.
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| CN109316595A (en) * | 2018-12-18 | 2019-02-12 | 丹东瑞丰动物药业有限责任公司 | A kind of Chinese medicine and preparation method thereof for treating dog cat canker sore |
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| CN109316595A (en) * | 2018-12-18 | 2019-02-12 | 丹东瑞丰动物药业有限责任公司 | A kind of Chinese medicine and preparation method thereof for treating dog cat canker sore |
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