CN108704077B - Traditional Chinese veterinary medicine composition for treating cat stomatitis and preparation method thereof - Google Patents
Traditional Chinese veterinary medicine composition for treating cat stomatitis and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/86—Violaceae (Violet family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a traditional Chinese veterinary medicine composition for treating cat stomatitis and a preparation method thereof, and is characterized in that: 10-30 parts of radix rehmanniae, 5-15 parts of lotus plumule, 10-40 parts of Chinese violet, 5-20 parts of honeysuckle, 5-20 parts of radix ophiopogonis, 5-20 parts of lophatherum gracile, 10-30 parts of astragalus membranaceus, 5-20 parts of codonopsis pilosula, 5-10 parts of glossy privet fruit and 5-20 parts of liquorice, wherein water in an amount which is 10-12 times the total weight of the medicinal materials is added, the decoction is carried out twice, each decoction is carried out for 1.0 hour, the filtration is carried out, the filtrates of the two times are combined, the filtrate is subjected to reduced pressure concentration until the relative density is 1.10-1.20 (60 ℃), and a corresponding preparation is prepared according to the preparation process of a required dosage form. The traditional Chinese medicine composition has a good treatment effect on cat stomatitis, can relieve symptoms of sialorrhea, halitosis, red and swollen oral mucosa and the like of a diseased cat, accelerates healing of oral ulcer surfaces, and reduces the recurrence rate of curing the diseased cat stomatitis.
Description
Technical Field
The invention belongs to the technical field of pet medicines, and particularly relates to a traditional Chinese veterinary medicine composition for treating cat stomatitis and a preparation method thereof.
Background
With the development of social economy and the improvement of the quality of life of people, the pet industry in China is rapidly developed, and the health of pets is increasingly valued by pet owners and pet doctors. The oral inflammatory ulcerative disease of the cat is one of the diseases which are very common in clinic, and the epidemic unrestrained cats and domestic cats in the clinic have the disease, wherein the epidemic unrestrained cats are more. The disease is complicated in inducement, and stomatitis may occur due to various sharp foreign matters such as stimulation of bone chips, thorns, iron wires, steel needles, wood thorns and the like, damage to irregular teeth, ingestion of corrosive chemical toxins or lack of vitamin A, B2 and the like. In addition, some infectious diseases, such as feline tracheitis virus and feline calyx virus, are the cause of ulcerative glossitis in cats, and some systemic diseases, anemia, can also cause stomatitis to occur. The appetite of the sick cats is reduced or lost in different degrees, abnormal ingestion and chewing are caused, the weight of the sick cats is obviously reduced for a long time, the sick cats are extremely thin, the spirit is low, oral mucosa is inflamed, ulcer and pain are caused, the sick cats cannot suck and chew, a large amount of saliva flows, and the peripheries of the lips are commonly provided with foam saliva and have odor. The disease is mainly treated by a conventional tooth extraction method at present, half or all teeth of a diseased cat are extracted according to the disease condition, and then antibiotic treatment is assisted. However, the method for treating the feline stomatitis has a high recurrence rate, and researches show that the recurrence rate of the half-mouth tooth extraction treatment method is up to 47.06 percent, the recurrence period is generally 30 to 90 days, the recurrence rate of the broken root extraction treatment method is 16.67 percent, the recurrence period is generally 7 to 14 days, the recurrence rate of the full-mouth tooth extraction is 15.38 percent, and the recurrence period is generally more than 90 days. In addition, the sick cats treated by tooth extraction not only need to suffer great pain, but also have obviously reduced life quality at the later stage, and only can eat liquid food or semi-liquid food.
Disclosure of Invention
The invention aims to provide a traditional Chinese veterinary medicine composition which is remarkable in curative effect and can be used for non-invasively treating cats suffering from cat stomatitis, based on the theory of traditional Chinese veterinarians and combined with clinical practice experience, aiming at various defects and deficiencies of the prior art.
In order to achieve the purpose, the inventor screens out the formula of the invention by long-term practical research on the basis of the theory of Chinese veterinary medicine, and the formula is characterized in that:
a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicinal components in parts by weight: 5-50 parts of radix rehmanniae, 3-30 parts of lotus plumule, 5-60 parts of Chinese violet, 3-30 parts of honeysuckle, 3-30 parts of radix ophiopogonis, 3-30 parts of lophatherum gracile, 5-50 parts of astragalus membranaceus, 3-30 parts of codonopsis pilosula, 3-20 parts of glossy privet fruit and 3-30 parts of liquorice.
A traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicinal components in parts by weight: 10-30 parts of radix rehmanniae, 5-15 parts of lotus plumule, 10-40 parts of Chinese violet, 5-20 parts of honeysuckle, 5-20 parts of radix ophiopogonis, 5-20 parts of lophatherum gracile, 10-30 parts of astragalus membranaceus, 5-20 parts of codonopsis pilosula, 5-10 parts of glossy privet fruit and 5-20 parts of liquorice.
A traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicinal components in parts by weight, preferably: 15 parts of radix rehmanniae, 10 parts of lotus plumule, 25 parts of Chinese violet, 10 parts of honeysuckle, 10 parts of dwarf lilyturf tuber, 10 parts of lophatherum gracile, 15 parts of astragalus, 10 parts of codonopsis pilosula, 5 parts of glossy privet fruit and 10 parts of liquorice.
The invention adopts water extraction method which is a general method in industry to prepare: weighing the medicinal materials according to the required weight parts, adding water which is 10-12 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates of the two times, concentrating the filtrate under reduced pressure until the relative density is 1.15-1.20 (60 ℃), and preparing the corresponding preparation according to the preparation process of the required dosage form.
The application mode of the composition in the pharmaceutical field is as follows: the composition can be made into oral dosage forms such as oral liquid, powder, granule, tablet, capsule, and unguent.
The formula principle of the invention is as follows:
according to traditional Chinese medicine dialectical theory, cat stomatitis is complicated in etiology, is mostly related to upward invasion of wind, fire and dryness, or unclean oral cavity, and direct invasion of damaged pathogenic toxin in oral cavity, and is mostly closely related to dysfunction of viscera such as heart, spleen and kidney. The therapeutic principle is mainly clearing away heat and toxic material, nourishing yin to reduce pathogenic fire, nourishing yin to promote fluid production, and strengthening body resistance to consolidate constitution. In the formula of the invention, the philippine violet herb, the honeysuckle, the lotus plumule and the lophatherum gracile are monarch drugs for clearing away heat and toxic materials, cooling blood and relieving swelling, purging fire and relieving restlessness and coordinating heart and kidney; rehmannia root and dwarf lilyturf tuber are used as ministerial drugs for nourishing yin, promoting the secretion of saliva or body fluid, cooling blood and clearing heart; radix astragali, radix codonopsitis and glossy privet fruit, which are used as adjuvant drugs for strengthening spleen and body resistance, consolidating the constitution and nourishing blood; licorice root, radix Glycyrrhizae is a guiding drug for tonifying the spleen and qi, relieving spasm and pain, and harmonizing the effects of the other drugs in the recipe.
Compared with the prior art, the invention has the following advantages and effects:
the invention relates to a traditional Chinese veterinary medicine composition prepared from natural plants and used for treating cat stomatitis, which has the effects of clearing away heat and toxic materials, nourishing yin to reduce pathogenic fire, nourishing yin to promote the production of body fluid, and strengthening body resistance to consolidate constitution by means of oral administration, can regulate the functions of heart, spleen, kidney and other viscera of a cat suffering from cat stomatitis, can safely and effectively relieve symptoms of sialorrhea, halitosis, red and swollen oral mucosa and the like of a cat suffering from cat stomatitis, can accelerate the healing of oral ulcer surfaces, and can promote the recovery of body weight. The life quality of the sick cat is not affected after the cure, the sick cat is not easy to relapse, and the economic burden and the psychological pressure brought to a pet owner by the operation tooth extraction treatment can be reduced.
Detailed Description
The present invention will be further described with reference to the following examples, which are intended to be illustrative only and not to be limiting of the invention in any way, and any person skilled in the art can modify the present invention by applying the teachings disclosed above and applying them to equivalent embodiments with equivalent modifications. Any simple modification or equivalent changes made to the following embodiments according to the technical essence of the present invention, without departing from the technical spirit of the present invention, fall within the scope of the present invention.
Example 1: a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicines: taking 15 parts of radix rehmanniae, 10 parts of lotus plumule, 25 parts of Chinese violet, 10 parts of honeysuckle, 10 parts of dwarf lilyturf tuber, 10 parts of lophatherum gracile, 15 parts of astragalus mongholicus, 10 parts of codonopsis pilosula, 5 parts of glossy privet fruit and 10 parts of liquorice, adding water which is 10 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates of the two times, concentrating the filtrate under reduced pressure until the relative density is 1.12(60 ℃), adding 2.5g of potassium sorbate, 2.5g of sodium benzoate and 5g of chicken essence, uniformly mixing, refrigerating for 24 hours at 4 ℃, filtering, adding water into the filtrate to adjust the total amount to 1000ml, sterilizing and filling to obtain the traditional Chinese veterinary medicine oral liquid for treating the stomatitis.
Example 2: a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicines: taking 20 parts of radix rehmanniae, 15 parts of lotus plumule, 30 parts of Chinese violet, 15 parts of honeysuckle, 15 parts of dwarf lilyturf tuber, 15 parts of lophatherum gracile, 15 parts of astragalus mongholicus, 15 parts of codonopsis pilosula, 5 parts of glossy privet fruit and 10 parts of liquorice, adding water which is 10 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates of the two times, concentrating the filtrate under reduced pressure until the relative density is 1.10(60 ℃), adding 2.5g of potassium sorbate, 2.5g of sodium benzoate and 5g of chicken essence, uniformly mixing, refrigerating at 4 ℃ for 24 hours, filtering, adding water into the filtrate to adjust the total amount to 1000ml, sterilizing and filling to obtain the traditional Chinese veterinary medicine oral liquid for treating the stomatitis.
Example 3: a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicines: taking 30 parts of radix rehmanniae, 10 parts of lotus plumule, 25 parts of Chinese violet, 5 parts of honeysuckle, 20 parts of dwarf lilyturf tuber, 10 parts of lophatherum gracile, 20 parts of astragalus mongholicus, 5 parts of codonopsis pilosula, 10 parts of glossy privet fruit and 20 parts of liquorice, adding water which is 10 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates of the two times, concentrating the filtrate under reduced pressure until the relative density is 1.12(60 ℃), adding 2.5g of potassium sorbate, 2.5g of sodium benzoate and 5g of chicken essence, uniformly mixing, refrigerating for 24 hours at 4 ℃, filtering, adding water into the filtrate to adjust the total amount to 1000ml, sterilizing and filling to obtain the traditional Chinese veterinary medicine oral liquid for treating the stomatitis.
Example 4: the traditional Chinese medicine composition is prepared by randomly composing according to a formula without following the weight part relationship of the traditional Chinese medicines in the formula, weighing 30 parts of radix rehmanniae, 8 parts of lotus plumule, 25 parts of Chinese violet, 40 parts of honeysuckle, 20 parts of dwarf lilyturf tuber, 10 parts of lophatherum gracile, 3 parts of astragalus mongholicus, 5 parts of codonopsis pilosula, 10 parts of glossy privet fruit and 20 parts of liquorice, adding water with the amount which is 10 times of the total weight of the medicinal materials, decocting twice, decocting for 1.0 hour each time, filtering, combining filtrates obtained after two times of decoction, concentrating the filtrate under reduced pressure to the relative density of 1.11(60 ℃), adding 2.5g of potassium sorbate, 2.5g of sodium benzoate and 5g of chicken essence, uniformly mixing, refrigerating for 24 hours at 4 ℃, filtering, adding water into the filtrate to adjust the total amount to 1000ml, sterilizing and filling to obtain the traditional Chinese veterinary medicine oral liquid for treating the stomatitis.
Example 5: the compatibility of the traditional Chinese medicines in the formula is not followed, the traditional Chinese medicines in the formula are randomly selected for composing the formula, 10 parts of radix rehmanniae, 10 parts of lotus plumule, 5 parts of honeysuckle, 20 parts of astragalus membranaceus and 15 parts of liquorice are weighed, water with the amount which is 10 times of the total weight of the traditional Chinese medicines is added, the decoction is carried out twice, each time is carried out for 1.0 hour, the filtration is carried out, the filtrates of the two times are combined, the filtrate is decompressed and concentrated to the relative density of 1.12(60 ℃), 2.5g of potassium sorbate, 2.5g of sodium benzoate and 5g of chicken essence are added, the mixture is uniformly mixed, the mixture is refrigerated at 4 ℃ for 24 hours, the filtration is carried out, the total amount of the filtrate is adjusted to 1000ml by adding water, and the traditional Chinese veterinary medicine oral liquid for treating the stomatitis of cats is obtained by sterilizing and filling.
Example 6: a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicines: taking 10 parts of radix rehmanniae, 10 parts of lotus plumule, 20 parts of Chinese violet, 20 parts of honeysuckle, 5 parts of dwarf lilyturf tuber, 20 parts of lophatherum gracile, 30 parts of astragalus mongholicus, 20 parts of codonopsis pilosula, 10 parts of glossy privet fruit and 5 parts of liquorice, adding water which is 10 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates obtained in two times, concentrating the filtrate under reduced pressure until the relative density is 1.17(60 ℃), performing spray drying, adding chicken liver powder, adjusting the total amount to 200g, and obtaining the traditional Chinese veterinary medicine powder for treating the stomatitis of cats.
Example 7: a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicines: taking 25 parts of radix rehmanniae, 5 parts of lotus plumule, 10 parts of Chinese violet, 10 parts of honeysuckle, 15 parts of dwarf lilyturf tuber, 5 parts of lophatherum gracile, 10 parts of astragalus mongholicus, 10 parts of codonopsis pilosula, 10 parts of glossy privet fruit and 15 parts of liquorice, adding water which is 10 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates obtained in two times, concentrating the filtrate under reduced pressure until the relative density is 1.20(60 ℃), performing spray drying, adding chicken liver powder, adjusting the total amount to 200g, and obtaining the traditional Chinese veterinary medicine powder for treating the stomatitis of cats.
Example 8: a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicines: taking 15 parts of radix rehmanniae, 15 parts of lotus plumule, 40 parts of Chinese violet, 15 parts of honeysuckle, 10 parts of dwarf lilyturf tuber, 15 parts of lophatherum gracile, 25 parts of astragalus mongholicus, 10 parts of codonopsis pilosula, 10 parts of glossy privet fruit and 10 parts of liquorice, adding water which is 10 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates obtained in two times, concentrating the filtrate under reduced pressure until the relative density is 1.17(60 ℃), performing spray drying, adding chicken liver powder, adjusting the total amount to 200g, and obtaining the traditional Chinese veterinary medicine powder for treating the stomatitis of cats.
Example 9: a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicines: taking 20 parts of radix rehmanniae, 10 parts of lotus plumule, 15 parts of Chinese violet, 20 parts of honeysuckle, 15 parts of dwarf lilyturf tuber, 15 parts of lophatherum gracile, 20 parts of astragalus mongholicus, 10 parts of codonopsis pilosula, 5 parts of glossy privet fruit and 20 parts of liquorice, adding water which is 10 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates obtained in two times, concentrating the filtrate under reduced pressure to relative density of 1.18(60 ℃), and spray-drying to obtain an extract; adding 200g of chicken liver powder, 75g of mannitol, 20g of polyethylene glycol and 25g of calcium carbonate, uniformly mixing, taking 70% ethanol as a wetting agent, preparing into granules, drying, adding magnesium stearate accounting for 1% of the total weight of the granules, uniformly mixing, tabletting according to the specification of 0.5g of each tablet to obtain 1000 tablets, and thus obtaining the veterinary traditional Chinese medicine tablet for treating the stomatitis of cats.
Example 10: a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicines: taking 15 parts of radix rehmanniae, 5 parts of lotus plumule, 35 parts of Chinese violet, 20 parts of honeysuckle, 20 parts of dwarf lilyturf tuber, 15 parts of lophatherum gracile, 30 parts of astragalus mongholicus, 20 parts of codonopsis pilosula, 10 parts of glossy privet fruit and 10 parts of liquorice, adding water which is 10 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates obtained in two times, concentrating the filtrate under reduced pressure to relative density of 1.18(60 ℃), and spray-drying to obtain an extract; adding 200g of chicken liver powder, 75g of mannitol, 20g of polyethylene glycol and 25g of calcium carbonate, uniformly mixing, taking 70% ethanol as a wetting agent, preparing into granules, drying, adding magnesium stearate accounting for 1% of the total weight of the granules, uniformly mixing, tabletting according to the specification of 0.5g of each tablet to obtain 1000 tablets, and thus obtaining the veterinary traditional Chinese medicine tablet for treating the stomatitis of cats.
Example 11: a traditional Chinese veterinary medicine composition for treating feline stomatitis comprises the following medicines: taking 10 parts of radix rehmanniae, 15 parts of lotus plumule, 25 parts of Chinese violet, 10 parts of honeysuckle, 5 parts of dwarf lilyturf tuber, 10 parts of lophatherum gracile, 30 parts of astragalus mongholicus, 10 parts of codonopsis pilosula, 10 parts of glossy privet fruit and 5 parts of liquorice, adding water which is 10 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates obtained in two times, concentrating the filtrate under reduced pressure to relative density of 1.19(60 ℃), and spray-drying to obtain an extract; adding 200g of chicken liver powder, 75g of mannitol, 20g of polyethylene glycol and 25g of calcium carbonate, uniformly mixing, taking 70% ethanol as a wetting agent, preparing into granules, drying, adding magnesium stearate accounting for 1% of the total weight of the granules, uniformly mixing, tabletting according to the specification of 0.5g of each tablet to obtain 1000 tablets, and thus obtaining the veterinary traditional Chinese medicine tablet for treating the stomatitis of cats.
Clinical trial for treating cat stomatitis
(1) Experimental Material
Animals: 90 sick cats with stomatitis in clinic.
Test drugs: the traditional Chinese veterinary medicine oral liquid prepared in the examples 1 to 5 is used as liquid medicine I to liquid medicine V correspondingly.
(2) Clinical symptoms of cat stomatitis
Abnormal ingestion and chewing, even no eating, the weight of the patient with longer course of disease is obviously reduced, the patient is extremely thin, the patient is uneasy to take the food, howling is caused by the pain caused by the stimulation of the food to the inflammation part, the mucous membrane of the oral cavity is red and swollen, the mouth is warm and high, the patient likes drinking water, and the patient breathes out in the mouth with unpleasant smell. The mouth drooling was severe, and the corners of the mouth were whitish. The body temperature is normal generally, but the body temperature is higher when the disease condition is serious, and when the disease develops into vesicular stomatitis, the oral mucosa can be seen to generate blisters with different sizes; when the oral cavity becomes ulcerative stomatitis, the mucous membrane has symptoms of rottenness, necrotic plaques, erosion and the like. The diagnosis of cat stomatitis is confirmed based on the above symptoms.
(3) Method of treatment
The cats suffering from the feline stomatitis are divided into 6 groups according to the clinical study randomization scheme requirements according to the case bringing sequence, wherein each group comprises 15 cats, namely a liquid medicine group, a liquid medicine group and a conventional treatment control group (hereinafter referred to as a control group). After the respective treatments, the phone call was returned continuously for 90 days.
Liquid medicine group-five liquid medicine groups: the oral cavity of the sick cat is washed by 1 percent potassium permanganate solution every day, and then the liquid medicines are respectively infused for one to five times with the dosage of 5ml/kg body weight, 2 times every day and 5 days of continuous administration.
Control group: the traditional tooth extraction method is mainly adopted for treatment according to different disease conditions: firstly, removing half-mouth teeth (except 4 canine teeth and incisor teeth, removing other teeth); ② the whole tooth is pulled out. After operation, the patient is fasted for 4 days, drinking water can be taken in the 2 nd day after operation, metronidazole infusion is continuously used for 3-5 days, and after the 5 th day, oral antibiotic treatment can be changed into 7 days.
(4) Criteria for therapeutic effect
And (3) healing: the oral cavity ulcer surface is healed, the mucosa is normal, the abnormal salivation phenomenon does not exist in the oral cavity, and the smell of the oral cavity is greatly improved;
the method has the following advantages: the ingestion and chewing are improved, the eating process can still make a whine, the area of the oral ulcer is reduced, the red and swollen phenomenon of the mucosa is reduced, the degree of the oral cavity salivation is reduced, and the smell of the oral cavity is reduced;
and (4) invalidation: the ingestion and chewing are not improved, the food refusal phenomenon is obvious, the area of the oral ulcer is increased or unchanged, the swelling phenomenon of the mucosa is aggravated, the degree of the oral salivation is aggravated or not improved, and the peculiar smell of the oral cavity is aggravated or not improved.
(5) The treatment effect is as follows: the statistics are shown in tables 1 and 2.
TABLE 1 statistical Table of cat stomatitis treatment results
Note: a represents a significant difference (P <0.05) compared to the control group; b represents a significant difference (P <0.05) compared to the four drug solutions; c showed significant difference (P <0.05) compared to the five drug solution groups.
As can be seen from table 1, the differences between the three groups of liquid medicines and the four groups of liquid medicines and the five groups of liquid medicines are significant (P <0.05) and the differences between the three groups of liquid medicines and the five groups of liquid medicines are not significant (P >0.05) in terms of the therapeutic effect of treating the cat stomatitis.
TABLE 2 statistics of the recurrence of stomatitis in cats with cure disease
| Group of | Recovery number (only) | Relapse within 90 days | Recurrence rate after recovery |
| Liquid medicine group | 11 | 1 | 9.1％ |
| Two groups of liquid medicine | 9 | 1 | 11.1％ |
| Three groups of liquid medicine | 10 | 1 | 10.0％ |
| Four groups of liquid medicine | 5 | 2 | 40.0％ |
| Five groups of liquid medicine | 2 | 1 | 50.0％ |
| Control group | 9 | 3 | 33.3％ |
As can be seen from Table 2, the effect of the first to third liquid medicines on the recurrence rate of the disease cats after healing is lower than that of the fourth, fifth and control liquid medicines.
The test results show that the traditional Chinese veterinary medicine composition has a good treatment effect on cat stomatitis, can relieve symptoms of oral salivation, halitosis, red and swollen oral mucosa and the like of cats suffering from cat stomatitis, accelerates the healing of oral ulcer surfaces, and can reduce the recurrence rate of the cat stomatitis with the cure disease to a certain extent.
Claims (5)
1. A traditional Chinese veterinary medicine composition for treating feline stomatitis is characterized by being prepared from the following raw material medicines in parts by weight: 15 parts of radix rehmanniae, 10 parts of lotus plumule, 25 parts of Chinese violet, 10 parts of honeysuckle, 10 parts of dwarf lilyturf tuber, 10 parts of lophatherum gracile, 15 parts of astragalus, 10 parts of codonopsis pilosula, 5 parts of glossy privet fruit and 10 parts of liquorice.
2. A traditional Chinese veterinary medicine composition for treating feline stomatitis is characterized by being prepared from the following raw material medicines in parts by weight: 20 parts of radix rehmanniae, 15 parts of lotus plumule, 30 parts of Chinese violet, 15 parts of honeysuckle, 15 parts of dwarf lilyturf tuber, 15 parts of lophatherum gracile, 15 parts of astragalus, 15 parts of codonopsis pilosula, 5 parts of glossy privet fruit and 10 parts of liquorice.
3. A traditional Chinese veterinary medicine composition for treating feline stomatitis is characterized by being prepared from the following raw material medicines in parts by weight: 30 parts of radix rehmanniae, 10 parts of lotus plumule, 25 parts of Chinese violet, 5 parts of honeysuckle, 20 parts of dwarf lilyturf tuber, 10 parts of lophatherum gracile, 20 parts of astragalus, 5 parts of codonopsis pilosula, 10 parts of glossy privet fruit and 20 parts of liquorice.
4. The veterinary drug composition for treating feline stomatitis according to any one of claims 1 to 3, wherein the preparation method of the raw material drugs comprises the following steps: weighing the medicinal materials according to the required weight parts, adding water which is 10-12 times of the total weight of the medicinal materials, decocting twice for 1.0 hour each time, filtering, combining filtrates of the two times, concentrating the filtrate under reduced pressure until the relative density is 1.10-1.20 (60 ℃), and preparing the corresponding preparation according to the preparation process of the required dosage form.
5. Use of the veterinary drug composition according to any one of claims 1 to 4 in the preparation of a medicament for treating feline stomatitis.
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