CN107510753B

CN107510753B - Traditional Chinese medicine composition for treating intractable hemoptysis and application thereof

Info

Publication number: CN107510753B
Application number: CN201710778165.5A
Authority: CN
Inventors: 黄海茵; 吴银根; 杨佩兰; 汤杰; 王振伟; 姚亮; 张谊; 陈绘佳; 钟秀君; 沈圆圆
Original assignee: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of TCM
Current assignee: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of TCM
Priority date: 2017-09-01
Filing date: 2017-09-01
Publication date: 2020-08-04
Anticipated expiration: 2037-09-01
Also published as: CN107510753A

Abstract

The invention relates to a traditional Chinese medicine composition for treating intractable hemoptysis, which is prepared from the following raw material medicines: charred pollen Typhae, charred radix Rubiae, Ophicalcitum, fructus Ligustri Lucidi, Ecliptae herba, Mori fructus, radix Arnebiae, and herba Euphorbiae Humifusae. The invention also provides application of the traditional Chinese medicine composition. Its advantages are: the traditional Chinese medicine composition has remarkable curative effect on refractory bronchiectasis hemoptysis (namely, a small amount of hemoptysis or phlegmatic blood persists after various traditional Chinese and western medicine treatment means), has the effective rate of over 90 percent, and has no toxic or side effect.

Description

Traditional Chinese medicine composition for treating intractable hemoptysis and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating intractable hemoptysis and application thereof.

Background

Hemoptysis refers to bleeding from any part of the respiratory tract or lung below the larynx, which is discharged from the mouth by a cough. It is a common symptom in the lung, especially in bronchiectasis.

For hemoptysis, the pathogenesis of traditional Chinese medicine is that the upper-jiao is hot, the qi and fire are reversed, or the exogenous wind-heat or wind-cold pathogen is accumulated to transform heat, and the heat is accumulated in the lung to cause hemoptysis. Generally, it is usually indicated for clearing liver fire or clearing lung heat and resolving phlegm, cooling blood and stopping bleeding, and it can be cured. However, clinically, some patients with bronchiectasis (or chronic pulmonary infection) have hemoptysis which is controlled or relieved partially by various traditional Chinese and western medicine treatment means (some patients have bronchial artery embolization), but a small amount of hemoptysis or phlegmatic blood still persists and cannot be cured. Belongs to the category of refractory hemoptysis (refractory hemoptysis).

Chinese patent document CN103611137A discloses a medicine for treating bronchiectasis hemoptysis, which is prepared from radix adenophorae, radix glehniae, radix rehmanniae, radix scrophulariae, myrobalan, fructus gardeniae, pericarpium trichosanthis, almond, cacumen biotae and other medicines according to a certain weight ratio. Chinese patent document CN105031263A discloses a traditional Chinese medicine for treating bronchiectasis hemoptysis due to fire excess from yin deficiency: gypsum Fibrosum, rhizoma anemarrhenae, radix Glehniae, radix Adenophorae, rhizoma Schizocapsae Plantagineae, radix scrophulariae, radix Paeoniae Rubra, cornu Bubali, radix Arnebiae, herba seu radix Cirsii Japonici, herba Cephalanoploris, folium Platycladi, rhizoma Bletillae, folium Callicarpae Formosanae, radix Codonopsis, Atractylodis rhizoma, radix Rubiae, radix Musae Plantagineae, rhizoma Polygonati, and Glycyrrhrizae radix. Chinese patent document CN105012703A discloses a traditional Chinese medicine for treating qi deficiency and blood stasis type bronchiectasis hemoptysis: ginseng, astragalus, Chinese yam, tap blood, cauda edulis, madder, pseudo-ginseng, mussel leaf, bletilla, beautyberry, stringy stonecrop herb, ligusticum wallichii, crassula arboricola and liquorice. Chinese patent document CN105012704A discloses a traditional Chinese medicine for treating liver-fire attacking lung type bronchiectasis hemoptysis: gypsum Fibrosum, rhizoma anemarrhenae, fructus Gardeniae, Prunellae Spica, semen Celosiae, radix scrophulariae, radix Paeoniae Rubra, cornu Bubali, herba seu radix Cirsii Japonici, herba Cephalanoploris, folium Platycladi, rhizoma Bletillae, folium Callicarpae Formosanae, pericarpium Citri Reticulatae viride, rhizoma Cyperi, Haematitum preparata, and Glycyrrhrizae radix. Chinese patent document CN104491526A discloses a traditional Chinese medicine for treating hemoptysis due to bronchiectasis: mulberry leaf, coptis root, dalbergia wood, ophicalcitum, chrysanthemum, cowberry seed, dwarf lilyturf tuber, platycladus orientalis carbon, cortex lycii radicis, lily, aster, pseudo-ginseng, lotus rhizome node, fritillaria cirrhosa and lalang grass rhizome. However, the traditional Chinese medicine composition for treating intractable hemoptysis has not been reported at present.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating intractable hemoptysis caused by bronchiectasis (or chronic inflammation of lung) aiming at the defects in the prior art.

The second purpose of the invention is to provide the application of the traditional Chinese medicine composition for treating intractable hemoptysis.

In order to achieve the purpose, the invention adopts the technical scheme that: the traditional Chinese medicine composition for treating hemoptysis is prepared from the following raw material medicines in parts by weight: 14-16 parts of cattail pollen charcoal, 14-16 parts of India madder root charcoal, 28-32 parts of ophicalcitum, 14-16 parts of glossy privet fruit, 9-11 parts of eclipta alba, 14-16 parts of mulberry, 14-16 parts of lithospermum and 14-16 parts of humifuse euphorbia herb.

The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15 parts of cattail pollen charcoal, 15 parts of madder charcoal, 30 parts of ophicalcitum, 15 parts of glossy privet fruit, 10 parts of eclipta alba, 15 parts of mulberry fruit, 15 parts of lithospermum and 15 parts of humifuse euphorbia herb.

In order to achieve the second object, the invention adopts the technical scheme that: the traditional Chinese medicine composition is applied to preparing a medicine for treating bronchiectasis.

The medicine is used for treating hemoptysis of bronchiectasis.

The hemoptysis is refractory hemoptysis.

The application of the traditional Chinese medicine composition in preparing a medicine for treating intractable hemoptysis.

The medicament dosage form is an oral preparation.

The oral preparation is pills, capsules, tablets, powder, granules or oral liquid.

The invention has the advantages that:

1. the traditional Chinese medicine composition has an obvious curative effect on intractable bronchiectasis hemoptysis, the effective rate is more than 90%, and no toxic or side effect is caused.

2. Under the guidance of the professor of Wuyinjin in the name of Shanghai city, the clinical refractory hemoptysis is considered to have prolonged course, and thus, the clinical refractory hemoptysis has complicated deficiency and excess, phlegm-heat is accumulated in the interior, yin is damaged after a long time, and blood leaving meridians exists. Honest as Zhang Jingyue, there are many cases of "deficiency of yin fluid of liver and kidney, excessive fire due to water deficiency, criminal gold due to excessive fire, lung dryness due to gold disease, and hemoptysis due to collateral damage due to lung dryness". It has the self-action of "strengthening water and tonifying yin, moistening, cooling blood and stopping bleeding". Therefore, the recipe takes Jiawei Erzhi pill as the principal drug, the Erzhi pill, which is from syndrome treatment guideline, and is composed of ligustrum lucidum and eclipta. Has the functions of tonifying liver and kidney, nourishing yin and stopping bleeding. In the recipe, ligustrum lucidum is sweet, bitter and neutral. Enter liver and kidney meridians. Has the functions of tonifying kidney, nourishing yin, nourishing liver and improving vision. Eclipta alba is sweet, sour and cold. Enter liver and kidney meridians. Has the functions of nourishing yin, tonifying the kidney, cooling blood and stopping bleeding. Both herbs enter liver and kidney meridians, tonify liver and kidney, clear deficiency heat, and reinforce the action of cooling blood and stopping bleeding. The fruit cluster of mulberry. The book Ben Cao Jing Shu (Ben Cao Jing Shu) says: the essence of sang, also … …, is sweet and cold and can nourish blood, and heat-removing … … herbs can cool blood, tonify blood and nourish yin. The combination of the mulberry fruit, the glossy privet fruit and the eclipta alba is called modified Erzhi pill which is used for nourishing yin, enriching blood and stopping bleeding. Because of the 'blood stasis is needed after long-term illness', cattail pollen, India madder root charcoal and ophicalcitum are used for removing blood stasis and stopping bleeding, and blood is not remained and not sticky. Radix Arnebiae and herba Euphorbiae Humifusae can be used for clearing phlegm-heat, cooling blood, removing blood stasis and stopping bleeding. Thus, nourishing yin and cooling blood, removing blood stasis and stopping bleeding, and clearing phlegm-heat, which tightly fastens the pathogenesis of intractable hemoptysis, the chronic disease can be eliminated. Has unique curative effect on difficult-to-treat hemoptysis of branch and branch expansion.

3. In addition, the traditional Chinese medicines used in the prescription of the invention are all common traditional Chinese medicines, the medicine sources are easy to obtain, and the cost is low. The traditional Chinese medicine composition is a traditional Chinese medicine composition aiming at intractable hemoptysis, and has the advantages of obvious curative effect, low cost and little toxic and side effect.

Detailed Description

The following examples are provided to illustrate specific embodiments of the present invention.

Example 1 refractory hemoptysis formula

15 parts of cattail pollen charcoal, 15 parts of madder charcoal, 30 parts of ophicalcitum, 15 parts of glossy privet fruit, 10 parts of eclipta alba, 15 parts of mulberry fruit, 15 parts of lithospermum and 15 parts of humifuse euphorbia herb.

Example 2 refractory hemoptysis formula

14 parts of cattail pollen charcoal, 15 parts of India madder root charcoal, 29 parts of ophicalcitum, 15 parts of glossy privet fruit, 9 parts of eclipta alba, 16 parts of mulberry fruit, 15 parts of lithospermum and 15 parts of humifuse euphorbia herb.

Example 3 refractory hemoptysis formula

16 parts of cattail pollen charcoal, 15 parts of madder charcoal, 31 parts of ophicalcitum, 16 parts of glossy privet fruit, 10 parts of eclipta alba, 15 parts of mulberry fruit, 16 parts of lithospermum and 14 parts of humifuse euphorbia herb.

Example 4 refractory hemoptysis formula

15 parts of cattail pollen charcoal, 14 parts of India madder root charcoal, 32 parts of ophicalcitum, 14 parts of glossy privet fruit, 11 parts of eclipta alba, 15 parts of mulberry fruit, 14 parts of lithospermum and 15 parts of humifuse euphorbia herb.

Example 5 refractory hemoptysis formula

15 parts of cattail pollen charcoal, 16 parts of madder charcoal, 28 parts of ophicalcitum, 15 parts of glossy privet fruit, 10 parts of eclipta alba, 14 parts of mulberry fruit, 15 parts of lithospermum and 16 parts of humifuse euphorbia herb.

EXAMPLE 6 decoction

The Chinese medicinal composition of examples 1 to 5 was decocted in water to obtain a decoction.

Example 7 granules

The Chinese medicinal composition of examples 1-5, decocting in water for 3 times, mixing filtrates, and concentrating to obtain fluid extract with relative density of 1.1. Adding ethanol into the fluid extract, standing for 24 hours, filtering, recovering ethanol, and concentrating to obtain a thick paste with a relative density of 1.2. Spray drying the soft extract to obtain dry extract fine powder. Adding dextrin into the dry extract fine powder, mixing, granulating by conventional method, drying, and making into granule.

Example 8 dispersible tablets

The Chinese medicinal composition of examples 1-5, decocting in water for 3 times, mixing filtrates, and concentrating to obtain fluid extract with relative density of 1.1. Spray drying the fluid extract to obtain dry extract fine powder. Mixing the dry extract fine powder with sodium carboxymethyl starch and microcrystalline cellulose, granulating by conventional method, drying, adding magnesium stearate and silicon dioxide, mixing, tabletting by conventional method, and making into dispersible tablet.

EXAMPLE 9 capsules

The Chinese medicinal composition of examples 1-5, decocting in water for 3 times, mixing filtrates, and concentrating to obtain fluid extract with relative density of 1.15. Spray drying the fluid extract to obtain dry extract fine powder. Adding magnesium stearate and pulvis Talci, mixing, adding hollow capsule by conventional method, and making into capsule.

EXAMPLE 10 pellets

The Chinese medicinal composition of examples 1-5, decocting in water for 3 times, mixing filtrates, concentrating to fluid extract with relative density of 1.18. Spray drying the fluid extract to obtain fine powder. Adding appropriate amount of water or/and yellow wine, and making into watered pill. Or adding appropriate amount of ethanol and soybean oil to make soft mass, making into pill with pellet making machine, drying, sieving, and making into pellet. Or making dripping pill with polyethylene glycol as matrix and dimethyl silicone oil as condensate.

EXAMPLE 11 oral liquid

The Chinese medicinal composition of examples 1-5, decocting in water for 3 times, mixing filtrates, and concentrating to obtain fluid extract with relative density of 1.1. Adding ethanol into the fluid extract, standing for 24 hours, filtering, recovering ethanol, and concentrating to obtain a thick paste with a relative density of 1.2. Dissolving stevioside in pure water by conventional method, adding sodium benzoate and purified water, mixing with the soft extract, and making into oral liquid.

EXAMPLE 12 powder preparation

The Chinese medicinal composition of examples 1-5, which is pulverized into fine powder by a pulverizer. Sieving, and mixing the fine powder in a mixer to obtain powder.

Example 13 animal testing

1 materials of the experiment

1.1 Experimental animals

SD rats weighing 180-220 g each half male and female.

1.2 bacteria

Inoculating standard Pseudomonas aeruginosa to culture medium, culturing at 37 deg.C for 24 hr, washing several typical colonies with physiological saline, and adjusting to 10 concentration by turbidimetry⁵CFU/L, 2ml of pseudomonas aeruginosa solution is prepared.

1.3 Molding method

Rats were anesthetized with 2% sodium pentobarbital 30mg/kg intraperitoneal injection. Fixing in supine position, selecting 3cm position under lip, sterilizing conventionally, making longitudinal 1cm incision, exposing submaxillary muscle group, and separating gas outlet pipe longitudinally. A2 mm transverse incision is made in the wider tracheal cartilage space under the thyroid cartilage for tracheal intubation. The tracheal tube was slowly extended to about 3cm below the sternum angle and a tactile sensation was developed, namely the right lobe of the lung. 0.02ml 10 was quickly injected from the cannula with a microsyringe⁵Quickly pulling out the intubation tube and erecting the fixing plate by the CFU/L bacterial liquid and 1ml of gas, keeping the rat in a vertical position to relieve the respiratory disturbance, longitudinally suturing the trachea incision and transversely suturing the neck muscle group and the skin by two layers after the rat breathes stably, and using penicillin G1 ten thousand U/100 g/day for 3 days by intraperitoneal injection to prevent wound infection. Gavage with 50% glucose 10ml/100 g/day for 3 days. The model of bronchiectasis can be formed after 2 weeks of modeling.

1.4 methods of treatment

90 successfully molded rats were selected and randomly divided into A, B, C, D, E, F, G, H, I groups of 9 groups. 10 rats without molding were in group J.

Group A: example 1. The traditional Chinese medicine composition in the embodiment 1 is decocted into decoction, 5ml of the decoction is used for intragastric administration, and the decoction is taken 2 times a day for 2 weeks. The 5 times of the equivalent dose of a rat of 200g is taken as a treatment dose, which is equivalent to 13.5g of crude drug per day for gastric lavage.

Group B: example 3. The traditional Chinese medicine composition in the embodiment 3 is decocted into decoction, 5ml of the decoction is used for intragastric administration, and the decoction is taken 2 times a day for 2 weeks. The amount of the raw medicines is 13.5 g/day for gastric lavage.

Group C: example 5. The traditional Chinese medicine composition in the embodiment 5 is decocted into decoction, 5ml of the decoction is used for intragastric administration, and the decoction is taken 2 times a day for 2 weeks. The amount of the raw medicines is 13.5 g/day for gastric lavage.

Group D: 25 parts of cattail pollen charcoal, 25 parts of madder charcoal, 10 parts of ophicalcitum, 20 parts of glossy privet fruit, 20 parts of eclipta alba, 30 parts of mulberry, 30 parts of lithospermum and 10 parts of humifuse euphorbia herb are decocted into decoction, 5ml of the decoction is used for intragastric administration every time, 2 times a day and 2 weeks continuously. The amount of the raw medicines is 13.5 g/day for gastric lavage.

Group E: 15 parts of glossy privet fruit and 10 parts of eclipta alba are decocted into decoction, 5ml of the decoction is used for intragastric administration, and the decoction is taken 2 times a day for 2 weeks continuously. The amount of the raw medicines is 13.5 g/day for gastric lavage.

And F group: 15 parts of glossy privet fruit, 10 parts of eclipta alba and 15 parts of mulberry fruit are decocted into decoction, 5ml of the decoction is used for intragastric administration every time, 2 times a day and 2 weeks continuously. The amount of the raw medicines is 13.5 g/day for gastric lavage.

Group G: 15 parts of cattail pollen charcoal, 15 parts of India madder root charcoal, 30 parts of ophicalcitum, 15 parts of lithospermum and 15 parts of humifuse euphorbia herb are decocted into decoction, 5ml of the decoction is used for intragastric administration every time, 2 times a day and continuously for 2 weeks. The amount of the raw medicines is 13.5 g/day for gastric lavage.

Group H: ofloxacin. The gavage is performed 2 times a day for 2 weeks with 2ml of 0.2% ofloxacin solution each time.

Group I: and (4) model groups. After molding, 5ml of physiological saline is taken each time for intragastric administration, 2 times a day for 2 weeks.

Group J: blank control group. The feed was fed for 4 weeks without any treatment such as molding.

1.5 Observation index

The hematology index is as follows: blood was collected from the tail vein one day before administration and at the end of administration, respectively, and serum was prepared. Measurement of leukocytes (WBC) and Neutrophils (NEU).

2 results

2.1 results of changes in the white blood cell count in rat peripheral blood are shown in Table 1.

TABLE 1 change in the white blood cell count in peripheral blood of rats (10)⁹·L^-1)

Note: indicates P <0.05 by t-test compared to the group before administration.

Also indicated by t-test, P <0.05 in group a compared to E, F, G, and group I post-dose peripheral blood leukocyte counts.

2.2 results of changes in the peripheral blood neutrophil count of rats are shown in Table 2.

TABLE 2 change in peripheral blood neutrophil count in rats (10)⁹·L^-1)

Note: indicates P <0.05 by t-test compared to the peripheral blood neutrophil count of this group before administration.

Also indicated by t-test, P <0.05 in group a compared to E, F, G, and group I post-dose peripheral blood neutrophil counts.

EXAMPLE 14 toxicological test

20 Kunming white mice were subjected to intragastric administration with a tolerance concentration of 0.4ml/10g (equivalent to 0.88g crude drug/ml) of the decoction prepared from the Chinese medicinal composition of example 1, 1 time every 4 hours and 4 times within 1 day. After the administration, the mice were observed for 7 days continuously, and no death, abnormal reactions in appearance, activity, diet, body weight, etc. were observed. The maximum tolerance of the mice per 1 day of intragastric administration at this time was 140.8 g/kg.

The traditional Chinese medicine composition disclosed by the invention is prepared from eight traditional Chinese medicines such as cattail pollen charcoal, India madder root charcoal, ophicalcitum and the like, and the traditional Chinese medicine composition has no toxic medicinal materials and has no toxic or side effect and no obvious adverse reaction report.

Example 15 clinical trial

1 data and method

1.1 case selection

1.1.1 diagnostic criteria

The diagnosis of the bronchiectasis refers to the relevant standards in the eighth edition of internal science of the national high school textbook, namely, according to the medical history of chronic cough, purulent sputum, repeated hemoptysis, repeated infection of the same part of the lung and the like, the lung smells fixed and durable localized damp rales, and the prior medical history of respiratory tract infection or systemic disease which induces the bronchiectasis is combined, so that preliminary clinical diagnosis can be made; chest CT examinations (especially high resolution CT) can be definitively diagnosed.

Refractory hemoptysis diagnosis: through various traditional Chinese and western medicine treatment means (certain treatment means are through bronchial artery embolization), although partial control or alleviation is achieved, a small amount of hemoptysis or phlegmatic blood persists, and the patient cannot be cured. Diagnosable "refractory hemoptysis"

1.1.2 Chinese medicine for dialectical application

The observed cases are from outpatients of department of respiration in Yueyang Chinese and Western medicine combination hospital affiliated to Shanghai medicine university in 1 month to 2016 in 2010 and 12 months, meet the diagnosis standard of refractory branch expansion hemoptysis, and are classified as yin deficiency with internal heat and blood stasis in traditional Chinese medicine. In 56 cases, 21 of the males and 35 of the females were of median age 59. The traditional Chinese medicine composition is taken by 1 dose per day through water decoction and is taken by 2 times. One treatment course lasts for 2 months,

1.1.3 therapeutic efficacy evaluation criteria

And (3) curing: hemoptysis or phlegmatic blood disappeared without repetition.

Improvement: hemoptysis or phlegmatic blood decrease, and the condition of the patient is improved;

and (4) invalidation: there was no reduction in hemoptysis.

2 results

The results of the patient treatment are shown in table 3.

TABLE 3 treatment outcome for refractory hemoptysis patients

The treatment results in table 4 show that the traditional Chinese medicine composition has a remarkable curative effect on refractory hemoptysis, and the cure rate reaches 80.4%.

All patients are treated by the traditional Chinese medicine, and no obvious toxic or side effect is seen.

Example 16 typical cases one

XX, female, age 48, patient has recurrent cough, cough purulent sputum, hemoptysis from age 20, chest CT shows the branch and expansion of the left upper lung, and is treated with various antibiotics, phlegm eliminating and hemostasis in sequence, the disease condition is easy to repeat. Bronchus artery embolism hemostasis operation is performed in a third hospital because of massive hemoptysis before 4 months. The postoperative hemoptysis is reduced, but cough, purulent sputum and discontinuous phlegmatic blood still exist. Phlegm and blood appear at intervals of 1-2 weeks, and western medicine treatment is ineffective and is helped by traditional Chinese medicine treatment. Cough with profuse yellow purulent sputum, intermittent phlegm and blood, dryness and heat sensation, poor appetite and poor sleep. The tongue is reddish, the coating is thin and yellow, and the pulse is thready and wiry. Three weeks after the treatment of the present recipe, phlegmatic blood disappears. The treatment is continued, no hemoptysis recurrence is caused, and the subjective and physical strength is enhanced, the sleep is improved, and the dry heat sensation disappears.

Example 17 typical case two

Season X, male, age 58, repeated cough, purulent sputum cough, hemoptysis for 6 years, and more than three months. Chest CT showed secondary infection of two old pulmonary tuberculosis. Negative for finding acid-fast bacillus by sputum and negative for T lymphocyte spot test. Through various treatment means (including antibiotics, pituitrin and bronchial artery embolism hemostasis), the effect is not good enough, and more sputum blood appears every few days. Carving: cough, yellow purulent sputum with blood in the sputum. Dark red tongue with thin and yellow coating and thready and slippery pulse. After the treatment of the formula, the phlegm and blood gradually disappear, the symptoms of cough and expectoration are also improved, and the life quality is obviously improved.

The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating intractable hemoptysis is characterized by being prepared from the following raw material medicines in parts by weight: 14-16 parts of cattail pollen charcoal, 14-16 parts of India madder root charcoal, 28-32 parts of ophicalcitum, 14-16 parts of glossy privet fruit, 9-11 parts of eclipta alba, 14-16 parts of mulberry, 14-16 parts of lithospermum and 14-16 parts of humifuse euphorbia herb.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 15 parts of cattail pollen charcoal, 15 parts of madder charcoal, 30 parts of ophicalcitum, 15 parts of glossy privet fruit, 10 parts of eclipta alba, 15 parts of mulberry fruit, 15 parts of lithospermum and 15 parts of humifuse euphorbia herb.

3. The use of the Chinese medicinal composition according to any one of claims 1 and 2 in the preparation of a medicament for the treatment of refractory hemoptysis caused by bronchiectasis or chronic pulmonary inflammation.

4. The use according to claim 3, wherein said pharmaceutical dosage form is an oral formulation.

5. The use of claim 4, wherein the oral formulation is a pill, capsule, tablet, powder, granule or oral liquid.