CN104173705A - Traditional Chinese medicine composition for dissolving turbidity and clearing away lung-heat and preparation method thereof - Google Patents
Traditional Chinese medicine composition for dissolving turbidity and clearing away lung-heat and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for dissolving turbidity and clearing away the lung-heat and a preparation method thereof. The traditional Chinese medicine composition comprises the following ingredients by weight part: root of balloon flower, radix glycyrrhizae, cordate houttuynia, red tangerine peel, angelica and bulbus fritillariae thunbergii. Experiments prove that the traditional Chinese medicine composition provided by the invention can be used for treating the diseases of obstruction of the lung by phlegm, and has a better effect than those of the prior art.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to Chinese medicine composition of the turbid refreshing lung of a kind ofization and preparation method thereof.
Background technology
Expectorant is a kind of pathological product of its liquid thickness, once form the paathogenic factor that can become again a kind of secondary.Expectorant is foul heresy, is often called as expectorant turbid.
Theory of Chinese medical science thinks that expectorant is because human-body viscera function is not normal, water liquid dysbolismus and the pathological product that forms, and the generation of expectorant is how relevant with lung, spleen, kidney.If any saying of " the spleen being the source of producing phlegm ", " the lung being the utensil for storing phlegm ".Expectorant is turbid stagnantly itches part in throat, causes cough more than.The Xuan Tongsu that stagnation of phlegm air flue (trachea, bronchus etc.) more can affect lung qi falls, and causes cough, asthma, the disease such as uncomfortable in chest.Turbid phlegm obstructing in the lung is that lung is the key factor that each card (being equivalent to the various diseases of modern medicine respiratory system) produces and increases the weight of thus.
Lung is " canopy ", and the gas of main the whole body is reduced to basic exercise form with Xuan Fasu.Lung is salubrious, plays a crucial role for the normal performance of the physiological functions such as exhalation foul smell, spreading gas Tianjin.
Change turbid refreshing lung and refer to dispel the turbid a kind of method for the treatment of of expectorant in lung, be applicable to the turbid lung that stays in of expectorant, the be jammed syndrome of turbid phlegm obstructing lung of air flue, clinical coughing, to cough up phlegm, to pant, uncomfortable in chest, rale etc. is as main manifestations, is common in the various diseases such as bronchitis, pneumonia bronchiectasis, asthma, chronic pharyngitis.
Expectorant turbid " storage ", in lung, not only affects airway patency, and often can become virus, the base of bacterial growth and breeding, become scorching card source of generation.Especially the haze weather that in recent years numerous big or middle cities extensively occur in the whole nation, had become an independent initiation cough, the reason of coughing up phlegm already.In haze, on molecule, can adhere to pathogenic microorganism, can directly be sucked by mouth and nose and enter pulmonary, expectorant in air flue turbid not remove to the greatest extent, then run into inspiring of exopathogen, cause the active of virus, antibacterial, the acute attack of scorching card, causes the recurrence of diseases of pulmonary system.As the acute bronchitis that is equivalent to lung system " cough " with the passing of time do not heal, develop into chronic bronchitis.Therefore, previously have the people of chronic respiratory system diseases, the haze sky state of an illness more easily recur or increase the weight of [Liang Dehao, cough caused analysis and the countermeasure [J] in king's Zhe .150 example haze sky. contemporary Chinese medicinal application, 2014,14 (8): 73-74].
Turbid of a specified duration the volt in lung of expectorant, also can injure lungs itself, causes the physiological function of lung to be badly damaged, the lung is concerned with QI of the whole body, lung qi fictitious pole, further can injure the heart, kidney,, there is feeling of distension and oppression over the chest, dyspnea and cough with excessive sputum in the function of impact " the main water of kidney ", " kidney governing inspiration " and " the main blood of the heart ", " the heart controlling mental and emotional activities ", cardiopalmus, the diseases such as edema, this shows turbid phlegm obstructing in the lung, does not with the passing of time heal, be further converted to " pulmonary distension ", be equivalent to modern medicine obstructive emphysema, pulmonary heart disease etc.Other lungs are the rule that each card also has similar transformation, so turbid phlegm obstructing in the lung is the key factor that development occurs various lung system's cards (being also various respiratory disease).Therefore, how effectively eliminating fast the turbid heresy of expectorant in lung, is one of important measures of the diseases such as clinical prevention respiratory system, cardio-cerebrovascular.
For the turbid Therapeutic Method of expectorant, modern medicine adopts the treatments such as ammonia chloride, bromhexine, carbocisteine more, and its mechanism is by reducing bronchorrhea secretion, the viscosity reducing or dissolving sticky expectorant, thereby eliminates the phlegm, expectoration.But these medicine thorniness swash gastric mucosa, often cause reflexively feel sick, the stomach discomfort sense such as vomiting.
Chinese traditional treatment turbid phlegm obstructing in the lung is point cold, wind, heat, the type determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs such as wet often.Have in the market the Chinese patent medicine of the expectoration effect of reducing phlegm, to treat expectorant heat syndrome as master and mostly to be syrup or sugaring granule, therapeutic effect is not ideal enough.This is because lung is " tender hide ", crosses by bitter cold or sweet greasy, can cause Lung Qi obstraction, and disorder of QI movement is not only unfavorable for that sputum discharges, also have imapirment of the spleen and stomach in bitter cold anxiety.
CN201210139937.8 (publication number is CN102688427A) discloses a kind of preparation method of Chinese medicine and this medicine pill for the treatment of senile chronic bronchitis.This Chinese medicine is made taking Herba Houttuyniae, Radix Isatidis, Rhizoma Osmundae, Rhizoma Paridis, Radix Saposhnikoviae, Folium Eriobotryae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Fructus Schisandrae Chinensis, Poria, Rhizoma Pinelliae, Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Flos Farfarae, Exocarpium Citri Rubrum, lepidii,semen and Radix Glycyrrhizae as raw material.
Existing compound recipe is made up of 19 herbal medicines such as Herba Houttuyniae, Radix Isatidis.In side, Herba Houttuyniae, Radix Isatidis, Rhizoma Osmundae, Rhizoma Paridis are the product of clearing up internal heat by using drugs of bitter in taste and cold in nature, the product that the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria etc. are temperature compensation, and Rhizoma Osmundae, Semen Armeniacae Amarum are all slightly poisonous; This side is unsuitable especially for the syndrome of turbid phlegm obstructing lung due to clinical common diseases caused by exogenous pathogenic factor pathogen.
Therefore, need to provide one first nontoxic, expense is cheap, the true medicable compound recipe for the treatment of syndrome of turbid phlegm obstructing lung.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of turbid phlegm obstructing in the lung determined curative effect.
Another object of the present invention is to provide the method for this Chinese medicine composition of preparation.
The Chinese medicine composition of the turbid refreshing lung of a kind ofization provided by the invention, is made up of following Chinese medicine: Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and Bulbus Fritillariae Thunbergii.
Concrete, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Platycodonis 5-15 part, Radix Glycyrrhizae 4-8 part, Herba Houttuyniae 20-40 part, Exocarpium Citri Rubrum 5-15 part, Radix Angelicae Sinensis 20-40 part and Bulbus Fritillariae Thunbergii 10-20 part.
Preferably, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Platycodonis 10-15 part, Radix Glycyrrhizae 6-8 part, Herba Houttuyniae 30-40 part, Exocarpium Citri Rubrum 5-15 part, Radix Angelicae Sinensis 20-40 part and Bulbus Fritillariae Thunbergii 10-20 part.
Further preferably, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Platycodonis 10-15 part, Radix Glycyrrhizae 6-8 part, Herba Houttuyniae 30-40 part, Exocarpium Citri Rubrum 10-15 part, Radix Angelicae Sinensis 30-40 part and Bulbus Fritillariae Thunbergii 15-20 part.
Further preferred, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: 20 parts of 15 parts of Radix Platycodoniss, 8 parts of Radix Glycyrrhizae, 40 parts of Herba Houttuyniae, 15 parts of Exocarpium Citri Rubrums, 40 parts of Radix Angelicae Sinensis and Bulbus Fritillariae Thunbergii.
In above-mentioned Chinese medicine composition:
Described weight portion can be the known unit of weights of field of medicaments such as μ g, mg, g, kg.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and the method comprises the following steps: take each Chinese medicine by proportioning, the decocting that adds Chinese medicine gross weight 6-10 doubly to measure boils 2-5 time, collects filtrate, concentrate drying.
The present invention also provides the preparation containing above-mentioned Chinese medicine composition, is made up of above-mentioned Chinese medicine composition and pharmaceutically acceptable carrier or diluent.
Described preparation is tablet, capsule, pill, granule or oral liquid.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier of pharmaceutical field routine, are selected from one or more in filler, binding agent, disintegrating agent, lubricant, suspending agent, wetting agent, solvent, surfactant or correctives.
Described filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.;
Described binding agent is selected from cellulose derivative, alginate, starch, dextrin, gelatin or polyvinylpyrrolidone etc.;
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose;
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate;
Described suspending agent is selected from micropowder silica gel, Cera Flava, cellulose, solid polyethylene glycol;
Described wetting agent is selected from glycerol, tween 80, ethyoxyl castor oil hydrogenated or lecithin;
Described solvent is selected from ethanol, liquid polyethylene glycol, isopropyl alcohol, tween 80, glycerol, propylene glycol or vegetable oil, and described vegetable oil is selected from soybean oil, Oleum Ricini, Oleum Arachidis hypogaeae semen, mediation wet goods;
Described surfactant is selected from smooth or Polysorbate (tween) of dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fatty acid Pyrusussuriensis etc.;
Described correctives is selected from aspartame, Sucralose, essence, citric acid or saccharin sodium.
The application that the present invention also provides above-mentioned Chinese medicine composition and preparation thereof to reduce phlegm in turbid medicine in preparation, described expectorant is turbid is the type that in asthma, bronchiectasis, cough, pneumonia, bronchitis or chronic pharyngitis, syndrome belongs to turbid phlegm obstructing in the lung.
The turbid refreshing fluid-retention in the lung Chinese medicine composition of provided by the inventionization has the following advantages:
1, Fang Xie: Chinese medicine composition provided by the invention is total to Six-element Chinese medicine by Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Bulbus Fritillariae Thunbergii, Exocarpium Citri Rubrum and Radix Angelicae Sinensis and forms.
In side, the pungent loose hardship of Radix Platycodonis is let out, lung qi dispersing promoting the circulation of QI, dispelling phlegm and relieving sore-throat evacuation of pus, and no matter cold and heat all can be applied.
Herba Houttuyniae, acrid in the mouth is slightly cold, and returns lung meridian.Being good at removing summer-heat lung-heat, having the effect of tool eliminating carbuncle evacuation of pus, is the key medicine for the treatment of lung abscess.
Bulbus Fritillariae Thunbergii, bitter in the mouth is cold in nature, removing heat-phlegm, eliminating stagnation eliminating carbuncle, is used for the treatment of cough due to pathogenic wind-heat and expectorant heat stagnation lung card.Herba Houttuyniae and Bulbus Fritillariae Thunbergii mutual reinforcement between are use, have eliminating heat from the lung, the merit of eliminating stagnation expectorant.
Exocarpium Citri Rubrum, acrid in the mouth hardship, warm in nature.Return lung spleen channel.Bright merchant learns " medicine justice " meaning: " Exocarpium Citri Rubrum, pungently can walk crosswise eliminating stagnation, and the bitter decline of keeping straight on, is promoting the circulation of QI key medicine.Lid is controlled expectorant and must be regulated the flow of vital energy, the spontaneous recovery of diarrhea due to disorder of QI expectorant, thus with entering lung spleen, main all expectorant diseases, merit occupies on all expectorant medicines.”
Radix Angelicae Sinensis, sweet in the mouth, pungent, bitter, warm in nature, main cough with dyspnea, is gas medicine in blood, blood and gas fall.Exocarpium Citri Rubrum and Radix Angelicae Sinensis phase 5, regulate the flow of vital energy and nourish blood, eleminating phlegm and freeing channels.
Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Bulbus Fritillariae Thunbergii, Exocarpium Citri Rubrum, Radix Angelicae Sinensis six medicines match, and play altogether lung qi dispersing promoting the circulation of QI, and reducing phlegm, row is turbid, the merit of eliminating stagnation eliminating carbuncle.
The cold temperature of Chinese medicine composition provided by the invention is taken into account, the QI and blood people having the same aspiration and interest, and the property of medicine is gentle, eliminating evil and just do not hinder, and has the merit of expectorant, expectoration.
2, confirm through experiment, Chinese medicine composition provided by the invention can be used for the treatment of the turbid disease of blocking in lung of expectorant, and effect is better than prior art.
Detailed description of the invention
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: Chinese medicine composition and capsule thereof
1, raw material of Chinese medicine: Radix Platycodonis 5g, Radix Glycyrrhizae 4g, Herba Houttuyniae 20g, Exocarpium Citri Rubrum 5g, Radix Angelicae Sinensis 20g and Bulbus Fritillariae Thunbergii 10g.
2, preparation method:
1) take respectively Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and Bulbus Fritillariae Thunbergii, add the water of 8 times of amounts of Six-element Chinese medicine weight first to soak 30min, decoct 2 hours, filter, collect respectively filtrate and medicinal residues, medicinal residues boil with the decocting of 6 times of amounts of medical material weight, decoct 1.5 hours, merge decoction liquor, filter, being concentrated into relative density is the thick paste of 1.03 (50 DEG C), dry, pulverize, obtain Chinese medicine extract, for subsequent use;
2) take starch 50g, magnesium stearate 8g, then mix homogeneously with Chinese medicine extract, be distributed into capsule.
3, specification: 5g crude drug/grain.
Embodiment 2: Chinese medicine composition and capsule thereof
1, raw material of Chinese medicine: Radix Platycodonis 10g, Radix Glycyrrhizae 6g, Herba Houttuyniae 30g, Exocarpium Citri Rubrum 10g, Radix Angelicae Sinensis 30g and Bulbus Fritillariae Thunbergii 15g.
2, preparation method:
1) take respectively Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and Bulbus Fritillariae Thunbergii, add the water of 10 times of amounts of Six-element Chinese medicine weight first to soak 30min, decoct 2 hours, filter, collect respectively filtrate and medicinal residues, medicinal residues boil with the decocting of 8 times of amounts of medical material weight, decoct 2 hours, filter, merge decoction liquor, filter, being concentrated into relative density is the thick paste of 1.06 (50 DEG C), dry, pulverize, obtain Chinese medicine extract for subsequent use;
2) take starch 35g, microcrystalline Cellulose 10g, magnesium stearate 5g, then mix homogeneously with Chinese medicine extract, be distributed into capsule.
3, specification: 5g crude drug/grain.
Embodiment 3: Chinese medicine composition and tablet thereof
1, raw material of Chinese medicine: Radix Platycodonis 15g, Radix Glycyrrhizae 8g, Herba Houttuyniae 40g, Exocarpium Citri Rubrum 15g, Radix Angelicae Sinensis 40g and Bulbus Fritillariae Thunbergii 20g.
2, preparation method:
1) take respectively Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and Bulbus Fritillariae Thunbergii, add the water of 8 times of amounts of Six-element Chinese medicine weight first to soak 40min, decoct 3 hours, filter, collect respectively filtrate and medicinal residues, medicinal residues boil with the decocting of 6 times of amounts of medical material weight, decoct 1 hour, merge decoction liquor, filter, being concentrated into relative density is the thick paste of 1.03 (50 DEG C), dry, pulverize, obtain Chinese medicine extract for subsequent use;
2) take microcrystalline Cellulose 30g, starch 10g, magnesium stearate 6g, then mix homogeneously with Chinese medicine extract, direct compression.
3, specification: 5g crude drug/sheet.
Embodiment 4: Chinese medicine composition and granule thereof
1, raw material of Chinese medicine: Radix Platycodonis 5g, Radix Glycyrrhizae 4g, Herba Houttuyniae 30g, Exocarpium Citri Rubrum 15g, Radix Angelicae Sinensis 40g and Bulbus Fritillariae Thunbergii 20g.
2, preparation method:
1) take respectively Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and Bulbus Fritillariae Thunbergii, add the water of 8 times of amounts of Six-element Chinese medicine weight first to soak 30min, decoct 3 hours, filter, collect respectively filtrate and medicinal residues, medicinal residues boil with the decocting of 8 times of amounts of medical material weight, decoct 1.5 hours, merge decoction liquor, filter, being concentrated into relative density is the thick paste of 1.03 (50 DEG C), dry, pulverize, obtain Chinese medicine extract for subsequent use;
2) take microcrystalline Cellulose 30g, starch 20g, magnesium stearate 6g, sucrose 10g, aspartame 5g, according to the granulation of established practice method, granulate, subpackage, to obtain final product with Chinese medicine extract.
3, specification: 5g crude drug/bag.
Embodiment 5: Chinese medicine composition and capsule thereof
1, raw material of Chinese medicine: Radix Platycodonis 15g, Radix Glycyrrhizae 8g, Herba Houttuyniae 30g, Exocarpium Citri Rubrum 5g, Radix Angelicae Sinensis 20g and Bulbus Fritillariae Thunbergii 10g.
2, preparation method:
1) taking respectively the decocting that Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and Bulbus Fritillariae Thunbergii add 10 times of amounts of medical material weight boils 3 times, decocting time is respectively 2 hours, 1.5 hours, 1.5 hours, merge decoction liquor, filter, being concentrated into relative density is the thick paste of 1.03 (50 DEG C), dry, pulverize, obtain Chinese medicine extract for subsequent use;
2) take starch 45g, magnesium stearate 5g, then mix homogeneously with Chinese medicine extract, be distributed into capsule.
3, specification: 5g crude drug/grain.
Experimental example 1: on the impact of the phenol red excretion amount of mice trachea section
1, laboratory animal: Kunming mouse, male and female half and half, weight 20 ± 2g.
2, experiment grouping and medication, dosage: 64 mices are divided into 8 groups at random, i.e. blank group, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 1 group of positive control, 2 groups of positive controls.Each Chinese medicine formula group mice dosage every day, ginseng document [Xu Shuyun, Bian Rulian, Chen Xiu. pharmacological experimental methodology (third edition) [M]. Beijing: People's Health Publisher, 2012:202-203] by people's common dose, carry out people, the conversion of mice dose,equivalent, morning and evening every day gastric infusion at twice.Blank group is with warm water gavage, (Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd produces with Exocarpium Citri Rubrum cough stopping oral liquor gavage for 1 group of positive control, consumption 3.03ml/kg body weight), 5% ammonium chloride gavage (brand: amresco for 2 groups of positive controls, article No. 0621-500G, the place of production: the U.S..Consumption: 1g/kg body weight).
3, experimental technique: respectively organize all continuous gavages 5 days of mice, 30min after last administration, lumbar injection 0.5% phenol red solution 0.5ml/ only, after 30min, put to death by de-cervical vertebra.Separate trachea, with surgical thread, respectively in thyroid cartilage lower edge and the ligation of trachea turnoff, self-ligating place clip trachea, with 1mL syringe absorption 5%NAHCO
3solution 0.5mL injects in trachea, repeatedly pushes away continuously and takes out 3 times, merges the about 1.2-1.5mL of flushing liquor, the centrifugal 10min of 3000r/min, get supernatant and measure absorbance (OD value) in 546nm wavelength place, by the phenol red standard curve of OD value substitution, draw phenol red concentration.
4, statistical method: measurement data with mean add and subtract standard deviation (
) represent, adopt SPSS17.0 statistical software, between group, relatively adopt one factor analysis of variance.
5, experimental result: in table 1
The impact of table 1 on the phenol red excretion amount of mice trachea section (
)
Note: with the comparison of blank group,
Δp < 0.05,
Δ Δp < 0.01
Table 1 result shows: with the comparison of blank group, embodiment 1-5 respectively organizes the phenol red excretion amount of mice trachea section difference all significant difference (P < 0.05 or P < 0.01), the phenol red excretion amount of mice trachea section all obviously increases, with embodiment 2 curative effect the bests.
Experimental result shows that Chinese medicine composition provided by the invention have expectoration effect, and effect is better than prior art.Inventor finds that its effect is better than containing the composition effect that Apophlegmatisant content is higher in the time that Apophlegmatisant ratio is suitable in Chinese medicine composition of the present invention simultaneously.
Experimental example 2: rat expectoration experiment
1, laboratory animal: SD rat, weight 200 ± 20g, male and female half and half.
2, experiment grouping and medication, dosage: 48 mices are divided into 8 groups at random, be blank group, 1 group of formulation Example, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 1 group of positive control, 2 groups of positive controls, 6 every group.Each Chinese medicine formula group rat dosage every day ginseng document [Xu Shuyun, Bian Rulian, Chen Xiu. pharmacological experimental methodology (third edition) [M]. Beijing: People's Health Publisher, 2012:202-203] by people's common dose, carry out people, the conversion of rat dose,equivalent, morning and evening every day gastric infusion at twice.Blank group is with warm water gavage, (Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd produces with Exocarpium Citri Rubrum cough stopping oral liquor gavage for 1 group of positive control, consumption 2.1ml/kg body weight), 5% ammonium chloride gavage (brand: amresco for 2 groups of positive controls, article No. 0621-500G, the place of production: the U.S..Consumption: 1g/kg body weight).
3, experimental technique: before experiment, fasting be can't help after water 12h, after 25% urethane 1.0g/kg intraperitoneal injection of anesthesia, back of the body position is fixing, expose trachea, an aperture is pricked with sharp-pointed injection needle in the 3rd cartilaginous ring position under thyroid cartilage ring (or trachea thyroid cartilage lower edge or hits exactly between two cartilaginous rings at thyroid cartilage lower edge), one of the capillary glass-tube that inserts long 120mm internal diameter 0.5mm, capillary tube just contacts trachea lower surface, so as to drawing organ rear portion sputum.Draw sputum length as expectorant secretory volume using capillary tube, record after the normal secretory volume of the front 2h of administration, after gastric infusion, continue to observe 2h sputum secretory volume, relatively administration forward backward averaging sputum secretory volume per hour, and the Epidemiological Analysis that takes statistics.
Urethane respectively gavage gives the corresponding test liquid of 1.0mL/100g.Before experiment, water 8-12h is can't help in fasting, after last administration 1h, records after administration the amount of expectoration of sucking-off in 2h, with capillary tube, calculates gain percentage after administration forward backward averaging expectorant secretory volume hourly and administration.
4, statistical method: measurement data with mean add and subtract standard deviation (
) represent, adopt SPSS17.0 statistical software, between group, relatively adopt one factor analysis of variance.
5, experimental result: in table 2
The impact of table 2 on rat expectoration amount (
)
Note: with the comparison of blank group,
Δp < 0.05,
Δ Δp < 0.01.
Table 2 result shows: with the comparison of blank group, embodiment 1-5 respectively organizes rat expectoration amount all significant difference (P < 0.05), and rat expectoration amount all obviously increases, with embodiment 2 curative effect the bests.Experimental result shows, Chinese medicine composition provided by the invention has expectoration effect, and effect is better than prior art.Inventor finds that its effect is better than containing the composition effect that expectoration medicament contg is higher in the time that expectoration drug ratios is suitable in Chinese medicine composition of the present invention simultaneously.
Although, above use general explanation, detailed description of the invention and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. a Chinese medicine composition of changing turbid refreshing lung, is characterized in that, this Chinese medicine composition is made up of following Chinese medicine: Radix Platycodonis, Radix Glycyrrhizae, Herba Houttuyniae, Exocarpium Citri Rubrum, Radix Angelicae Sinensis and Bulbus Fritillariae Thunbergii.
2. Chinese medicine composition according to claim 1, is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Platycodonis 5-15 part, Radix Glycyrrhizae 4-8 part, Herba Houttuyniae 20-40 part, Exocarpium Citri Rubrum 5-15 part, Radix Angelicae Sinensis 20-40 part and Bulbus Fritillariae Thunbergii 10-20 part.
3. Chinese medicine composition according to claim 2, is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Platycodonis 10-15 part, Radix Glycyrrhizae 6-8 part, Herba Houttuyniae 30-40 part, Exocarpium Citri Rubrum 5-15 part, Radix Angelicae Sinensis 20-40 part and Bulbus Fritillariae Thunbergii 10-20 part.
4. Chinese medicine composition according to claim 3, is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Platycodonis 10-15 part, Radix Glycyrrhizae 6-8 part, Herba Houttuyniae 30-40 part, Exocarpium Citri Rubrum 10-15 part, Radix Angelicae Sinensis 30-40 part and Bulbus Fritillariae Thunbergii 15-20 part.
5. Chinese medicine composition according to claim 1, is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: 20 parts of 15 parts of Radix Platycodoniss, 8 parts of Radix Glycyrrhizae, 40 parts of Herba Houttuyniae, 15 parts of Exocarpium Citri Rubrums, 40 parts of Radix Angelicae Sinensis and Bulbus Fritillariae Thunbergii.
6. prepare the Chinese medicine composition described in claim 1-5 any one, it is characterized in that, the method comprises the following steps: take each Chinese medicine by proportioning, the decocting that adds Chinese medicine gross weight 6-10 doubly to measure boils 2-5 time, collects filtrate, concentrate drying.
7. containing the preparation of the Chinese medicine composition described in claim 1-5 any one, it is characterized in that, said preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier or diluent.
8. preparation according to claim 7, is characterized in that, described preparation is tablet, capsule, pill, granule or oral liquid.
9. the Chinese medicine composition described in claim 1-5 any one or the application of the preparation described in claim 7 or 8 in the medicine of the turbid refreshing lung of preparationization.
10. application according to claim 9, is characterized in that, the turbid refreshing lung of describedization is applicable to the diseases such as asthma, bronchiectasis, cough, pneumonia, bronchitis or chronic pharyngitis and waits the type that belongs to turbid phlegm obstructing in the lung.
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| CN201410448277.0A Active CN104173705B (en) | 2014-09-04 | 2014-09-04 | Chinese medicine composition of the turbid refreshing lung of a kind ofization and preparation method thereof |
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Cited By (4)
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| CN104510938A (en) * | 2014-12-23 | 2015-04-15 | 蓝蓉蓉 | Traditional Chinese medicinal formula for treating infantile pneumonia and preparation method for syrup of traditional Chinese medicinal formula |
| CN109200125A (en) * | 2018-11-30 | 2019-01-15 | 哈工大机器人（山东）智能装备研究院 | A kind of campanulaceae compound buccal lozenge and preparation method thereof causing respiratory disease for treating haze weather |
| CN109223956A (en) * | 2018-10-17 | 2019-01-18 | 中国人民解放军第二军医大学 | A kind of Chinese medicine composition and its extracting method and application for treating cough |
| CN113116986A (en) * | 2021-05-31 | 2021-07-16 | 广州医科大学附属第一医院（广州呼吸中心） | Traditional Chinese medicine composition for chronic obstructive pulmonary disease rehabilitation period and application thereof |
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| CN103127369A (en) * | 2013-03-04 | 2013-06-05 | 高雪 | Traditional Chinese medicine composition for treating respiratory tract haze disoperation and preparation method |
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| CN103127369A (en) * | 2013-03-04 | 2013-06-05 | 高雪 | Traditional Chinese medicine composition for treating respiratory tract haze disoperation and preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510938A (en) * | 2014-12-23 | 2015-04-15 | 蓝蓉蓉 | Traditional Chinese medicinal formula for treating infantile pneumonia and preparation method for syrup of traditional Chinese medicinal formula |
| CN109223956A (en) * | 2018-10-17 | 2019-01-18 | 中国人民解放军第二军医大学 | A kind of Chinese medicine composition and its extracting method and application for treating cough |
| CN109223956B (en) * | 2018-10-17 | 2021-06-18 | 中国人民解放军第二军医大学 | Traditional Chinese medicine composition for treating cough and extraction method and application thereof |
| CN109200125A (en) * | 2018-11-30 | 2019-01-15 | 哈工大机器人（山东）智能装备研究院 | A kind of campanulaceae compound buccal lozenge and preparation method thereof causing respiratory disease for treating haze weather |
| CN113116986A (en) * | 2021-05-31 | 2021-07-16 | 广州医科大学附属第一医院（广州呼吸中心） | Traditional Chinese medicine composition for chronic obstructive pulmonary disease rehabilitation period and application thereof |
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| CN104173705B (en) | 2018-04-03 |
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